Reactions 961 - 26 Jul 2003

■ Atypical antipsychotics are associated with a lowerrisk of tardive dyskinesia (TD) than conventionalantipsychotics, according to researchers from the US.To investigate the cumulative incidence of definitivetardive dyskinesia (TD) they conducted a study in 240psychiatric outpatients who met study criteria; 130were receiving a conventional antipsychotic (mostcommonly haloperidol or thioridazine) and 110 anatypical antipsychotic (risperidone 64.5%, olanzapine20.9% or quetiapine 14.5%). For those receiving aconventional antipsychotic, the mean cumulativeincidence of TD at 1, 3 and 6 months was 2.9%,19.3% and 44.9%, respectively, compared with 1.0%,3.4% and 24.1%, respectively, in those receiving anatypical antipsychotic.Dolder CR, et al. Incidence of tardive dyskinesia with typical versus atypicalantipsychotics in very high risk patients. Biological Psychiatry 53: 1142-1145,15 Jun 2003 800947382

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Reactions 26 Jul 2003 No. 9610114-9954/10/0961-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved