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ANTIVIRUS
Alfi Yasmina
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Mekanisme Kerja Antivirus
� Inhibitor uncoating
� Inhibitor sintesis RNA & DNA virus
� Inhibitor nucleoside RT
� Inhibitor nonnucleoside RT
� Inhibitor protease
� Inhibitor neuraminidase
� Inhibitor entry
� Lain-lain
Inhibitor Uncoating Virus
� Amantadin, rimantadin
� Profilaksis dan terapi (dalam 48 jam
munculnya gejala) influenza A
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Inhibitor Sintesis DNA & RNA Virus
� Asiklovir, famsiklovir, valasiklovir, gansiklovir, foskarnet, ribavirin
� Diaktifkan dalam tubuh oleh timidin kinase
� Timidin kinase virus lebih sensitif dibanding timidin kinase host
� Asiklovir, famsiklovir, valasiklovir: Terapi infeksi HSV, varicella, herpes zoster
� Gansiklovir (sangat toksik) & foskarnet: CMV retinitis pada AIDS
� Ribavirin: Infeksi RSV & influenza
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Inhibitor Nucleoside Reverse Transcriptase
� Analog timidin: zidovudin, stavudin
� Analog sitosin: lamivudin, zalsitabin, emtrisitabin
� Analog guanosin: abacavir
� Analog adenosin: didanosin
� Zidovudin, stavudin, abacavir, tenofovir,
emtrisitabin: HIV
� Didanosin, zalsitabin: HIV resisten zidovudin
� Lamivudin: hepatitis, HIV
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Inhibitor Non-nucleoside Reverse Transcriptase
� Nevirapin, delavirdin, efavirenz
� Tidak perlu fosforilasi
� Berikatan secara nonkompetitif dengan RT
HIV-1
� Sangat mudah terjadi resistensi
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Inhibitor protease
� Saquinavir, ritonavir, indinavir, nelfinavir,
amprenavir, fosamprenavir, lopinavir,
atazanavir, tipranavir
� Untuk terapi HIV
� Mudah resisten, harus dikombinasi dengan
anti-HIV lain
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Inhibitor neuraminidase
� Oseltamivir (oral), zanamivir (inhalasi)
� Menghambat neuraminidase mengakibatkan
agregasi virus ke permukaan sel &
menurunkan penyebaran virus dalam
saluran nafas
� Pencegahan & terapi influenza A dan B
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Inhibitor entry
� Enfuvirtid
� Untuk HIV-1
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Lain-lain
� Idoksuridin, trifluridin: infeksi HSV pada
kornea
� Interferon & Peg-interferon: hepatitis,
kondiloma akuminata
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