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AnnouncementsAnnouncements
Exams-
Extra Credit -
Lab 5 - Lymphatic System
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Lecture OverviewLecture Overview
Lymphatic System and Components– What is lymph and how does it travel?
General Immune Reaction- Inflammation– What is one function of the cells carried in
lymph?
Selected Topics in Immunity
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Lymphatic SystemLymphatic System
Absorbs excess fluid from the tissues
Returns this fluid to the circulatory system or the heart
Additional function in Immunity
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Components of the Lymphatic Components of the Lymphatic SystemSystem
LymphLymphatic TissueLymphatic VesselsThymusBone MarrowSpleen
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LymphLymph
Lymph– The clear fluid
absorbed by the lymphatic system
Lymphatic Tissue– Clusters of
Lymphocytes and macrophages
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Lymphatic TissueLymphatic Tissue
Malt: (Mucosa Associated Lymphatic Tissue) – Diffuse array of lymphocytes found along body
passages in mucous membranes.– Examples of malt: lining of the stomach and
respiratory tract
Lymph nodules: – Dense clusters of Lymphocytes – Transient: pop up during infection
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Lymphatic VesselsLymphatic Vessels Carry and Transport
Lymph and proteins
Similar Structure to veins– Tunica Interna: Thin
inner lining and valves– Tunica Media: Elastic
fibers and Smooth Muscle
– Tunica Externa: Thin Outer Layer
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Lymphatic FiltersLymphatic Filters
Lymph Nodes- Screen and Filter Lymph for infectious particles
Spleen- Screen and Filter Blood for old, dead cells and infectious particles
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Subclavian
2 collecting Trunks
6 Lymphatic Trunks
More Collecting Vessels
Lymph Nodes
Collecting Vessels
Lymphatic Vessels
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Lymphatic MovementLymphatic Movement
No pump
Rhythmic contraction of the lymph vessels
Skeletal Muscles
How is backflow prevented?
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Immune Cell GeneratorsImmune Cell Generators
Bone Marrow- Makes B- Cells
Thymus- Makes T- Cells
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ThymusThymus
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Break for Dynamic Human
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InflammationInflammation
Non-specific response to tissue trauma or infection
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44 signs of Inflammation signs of Inflammation
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44 signs of Inflammation signs of Inflammation
RednessSwellingHeatPain
What’s the purpose of pain?
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Purpose of InflammationPurpose of Inflammation
Remove Invading Pathogens
Remove Debris of Damaged Tissues
Initiate Tissue Repair
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Mediators of InflammationMediators of Inflammation
Chemical Messengers
Leukocyte
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Chemical MessengersChemical Messengers
Released by mast cells in response to damage
Bradykinin, Histamine, and Leukotrienes– Increases Local Blood Flow to distressed area
Stimulates Vasodilation Increases Permeability of Capillaries
What’s Accomplished?
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Chemical MessengersChemical Messengers
Bradykinin, Histamine, and Leukotrienes– Increases Local Blood Flow
Stimulates Vasodilation Increases Permeability of Capillaries
What’s Accomplished?– Heats area causes redness and swelling– Dilutes toxins and helps Remove waste– Supplies oxygen and nutrients for tissue repair
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Pain ResponsePain Response
Purpose?
Causes?
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Pain ResponsePain Response
Purpose? Prevents further injury to area.
Causes?– Direct Nerve Damage– Pressure from Swelling– Chemical Stimulation particularly bradykinin
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Leukocyte DeploymentLeukocyte Deployment
Leukocyte: any white blood cell including T cells, B cells, granulocytes, platelets, basophils, mast cells, monocytes and macrophages
Leukocytes Migrate toward inflammed area
Why? TO KILL and RECRUIT
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Leukocyte DeploymentLeukocyte DeploymentLeukocytes Migrate to inflammed tissue
How? 1. Margination or pavementing: To migrate to the wall of a capillary
2. Diapedesis: Passage of blood cells through vessel wall into tissue 3. Chemotaxis: Movement of a cell towards or away a chemical source
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What do the leukocytes plan What do the leukocytes plan to do?to do?
Phagocytosis: release of toxic chemicals
Recruit more leukocytes
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PhagocytosisPhagocytosis
Leukocytes consume and destroy foreign invaders and dead cells
Ejected as Pus
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Break for Break for Dynamic HumanDynamic Human
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Selected Topics in ImmunitySelected Topics in Immunity