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Curcumin’s Therapeutic Effects On
Inflammatory Bowel DiseaseReview paper presentation
Angélica M. González SánchezDecember 2, 2011.
BIOL 3095 - UPR Cayey
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What is IBD? Severe inflammation of the gastrointestinal wall.
Rare condition statistically - its implications on people’s quality of life make it a relevant field for investigations.
Unknown causes – linked to genetic, environmental and immunological factors
- Stress response
- uncontrolled pathways of molecules related to the immune system.
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,
Healthy Colon
Ulcerative Colon
Healthy Small Bowel
Images from: virtualmedicalcentre.com, bidmc.org, hopkins-gi.org
Crohn’s disease Small
Bowel
Types of IBD
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Complications and treatments:
Images from: ehow.com, doccarnahan.blogspot.com
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What is curcumin?Diferuloylmethane
Image from: Anand P, Thomas S, Kunnumakkara A, Sundaram C, Harikumar K, Sung B, Tharakan S, Misra K, Priyadarsini I, Rajasekharan K, Aggarwal B. 2008. Biological activities of curcumin and its
analogues (Congeners) made by man and Mother Nature. Biochemical Pharmacology Journal. 76(1):1590-1611.
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Obtained from the roots of the herb Curcuma longa.
Traditionally used in foods as a component of the spice turmeric and as an herbal remedy for several illnesses.
Image from: aliexpress.com
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Antioxidant, anti-inflammatory, antimicrobial and anti-carcinogenic activities.
(Anand et al., 2008)
Reasons for its capacities are not well known.-Linked to its ability to bind to several proteins and regulatory enzymes and to inhibit oxidation chain reactions. (Srivastava et al., 2011)
Regulates the presence of several molecules.
- cellular processes → stress response. - Transcription factors, enzymes and
proteins→ directly related to immunity and
inflammation.
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Macroscopic effects of curcumin on IBD
Decrease of inflammation
on the intestinal tissues
Weight gainIncrease in the rate of
survival
Related to microscopic processes of the cell
(Jian et al., 2005) (Salh et al., 2003)
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Deregulated molecules on IBD
Deregulated molecules that cause inflammation
on IBD
NF-κB
cytokines:- inflammatory ones (as IL-1β) are
over expressed- anti-inflammatory ones (as IL-10)
are under expressed
chemokines
p38 MAPK
lymphocytes
chemokines
cyclooxygenases & lipoxygenases
MPO hypoclorous acid radical & tyrosyl radical
(Jian et al., 2005) (Salh et al., 2003)(Srivastava et al., 2011)
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Microscopic effects of curcumin on IBD
- Regulates the NF-κB pathway, therefore, reduces IL-1β expression & increases IL-10
expression.
- Inhibits the excessive proliferation of white blood cells.
-Diminishes the activation of p38 MAPK, therefore controlling the production of
lymphocytes, chemokines, cyclooxygenases and lipoxygenases.
- Inhibits the oxidation of MPO by oxidizing itself, therefore, preventing that the free
radicals run freely in the body and reducing the oxidation chain reactions.
(Rajasekaran, 2011)(Srivastava et al., 2011)(Salh et al., 2003)
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Curcumin’s usage and limitations
(Anand et al., 2008)(Srivastava et al., 2011)(Rajasekaran, 2011)(Yadav et al., 2009)
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Conclusions Not so many researches = many aspects not
well comprehended = more research is needed.
Not all of the research has concluded curcumin’s effects in all the same molecules, but all of them have related its outcomes on its regulatory properties.
Good modulator of the appropriate quantities of molecules needed for stress response → related to IBD.
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ReferencesAnand P, Thomas S, Kunnumakkara A, Sundaram C, Harikumar K, Sung B, Tharakan S, Misra K, Priyadarsini I, Rajasekharan K, Aggarwal B. 2008. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochemical Pharmacology Journal. 76(1):1590-1611.
Jian Y, Mai G, Wang J, Zhang Y, Luo R, Fang Y. 2005. Preventive and therapeutic effects of NF-kappaB inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid. World Journal of Gastroenterology. 11(12):1747-1752.
Pithadia A, Jain S. 2011. Treatment of inflammatory bowel disease (IBD). Pharmacological Reports. 63(1):629-642.
Rajasekaran S. 2011. Therapeutic potential of curcumin in gastrointestinal diseases. World Journal of Gastrointestinal Pathophysiology. 2(1): 1-14.
Salh B, Assi K, Templeman V, Parhar K, Owen D, Gómez A, Jacobson K. 2003. Curcumin attenuates DNB-induced murine colitis. American Journal of Physiology Gastrointestinal and Liver Physiology. 285:G235-G243.
Srivastava R, Singh S, Dubey S, Misra K, Khar A. 2011. Immunomodulatory and therapeutic activity of curcumin. International Immunopharmacology Journal. 11(1):331-341.
Yadav V, Suresh S, Devi K, Seema Y. 2009. Effect of Cyclodextrin Complexation of Curcumin on its Solubility and Antiangiogenic and Anti-inflammatory Activity in Rat Colitis Model. AAPS PharmSciTech. 10(3):752-762.
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Questions?
Image from: ibstreatmentcenter.blogspot.com
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Thanks for your
attention!