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A PRIMAVERA
VEM AÍ…
Aproveitem melhores tempos !
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estamos hoje expostos a
vulcões de
estudos explosivos
que derramam as cinzas
das notícias erradas
sobre todo o Mundo…
![Page 5: A PRIMAVERA VEM AÍ… proferidas/Slides 2007/… · populações, e a confusão de riscos relativos com riscos absolutos! WHI and breast cancer Once again, it is apparent that the](https://reader034.vdocuments.site/reader034/viewer/2022042301/5ecc38521722067c72060701/html5/thumbnails/5.jpg)
como a conferência de
imprensa sobre o WHI:
com notícias muitíssimo
quentes…
![Page 6: A PRIMAVERA VEM AÍ… proferidas/Slides 2007/… · populações, e a confusão de riscos relativos com riscos absolutos! WHI and breast cancer Once again, it is apparent that the](https://reader034.vdocuments.site/reader034/viewer/2022042301/5ecc38521722067c72060701/html5/thumbnails/6.jpg)
e…, só mais tarde… a primeira
publicação do WHI (JAMA)…
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Os manifestos panfletários…
Os seus manifestos panfletários não
foram transmitidos em primeira mão
aos responsáveis pela saúde das
mulheres. Ao contrário, comunicaram-
nos à Imprensa que os aceitou
erróneamente como verdadeiros e os
publicou em títulos de caixa alta !
Assim conseguiram gerar o pânico nas
populações, e a confusão de riscos
relativos com riscos absolutos!
![Page 8: A PRIMAVERA VEM AÍ… proferidas/Slides 2007/… · populações, e a confusão de riscos relativos com riscos absolutos! WHI and breast cancer Once again, it is apparent that the](https://reader034.vdocuments.site/reader034/viewer/2022042301/5ecc38521722067c72060701/html5/thumbnails/8.jpg)
WHI and breast cancer
Once again, it is apparent that the alarmist
reports that spread world-wide when the
first results of the WHI study were
published in 2002 were unjustified based
on the more recent further analyses,
particularly in peri- and early
postmenopausal women.
Press statement of IMS. April 11, 2006.
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As encíclicas…
“O que é especialmente
preocupante acerca das
declarações e encíclicas das
prescrições é a aceitação cega da
infalibilidade do WHI e do MWS”
Sturdee D and MacLennan A –(Editorial) Should epidemiology, the media and
quangos determine clinical practice? Climacteric 2004;7:1-2
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“Baseado no grupo de estudo do WHI, a
implementação dos resultados
para a clínica tem pouca base científica, se é que tem alguma…”
Adam Ostrzenski and Katarzyna M Ostrzenska. Am J Obst Gynecol
2005;193:1599-604
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The women enrolled in WHI and HERS
initiated EPT more than a decade after
menopause on average, and the majority
of events that produced this pattern
occurred in older women.
March 2007 position statement of The North American
Menopause Society.Menopause 2007;14(2):1-17
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Data from large studies such as the WHI and HERS should not be extrapolated to symptomatic postmenopausal women younger than 50 years of age who initiate HT at that time as these women were not
studied in those trials
March 2007 position statement of The North American Menopause Society.Menopause 2007;14(2):1-17
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It is not possible to extrapolate
conclusions from the study of one
compound, dose, and route of
administration directly to another.
March 2007 position statement of The North American
Menopause Society.Menopause 2007;14(2):1-17
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The WHI study was not designed, and therefore was not powered, to investigate the consequences of hormone therapy (HT) in women below 60 years of age.
Press statement of IMS. February 13, 2006.
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e ….
os investigadores do WHI
não sabem interpretar os seus resultados…
a pesar de os apresentarem
como a verdade…
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“O Estudo da Saúde das
Enfermeiras (NHS) e outros
semelhantes podem estar
correctos e o WHI estar
equivocado, ou vice-versa”
Rossouw J, 2003
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”Pode suceder também que cada um deles esteja equivocado.
Talvez o estrogénio das pastilhas não seja a molécula em que nos devamos concentrar”
Rossouw J, 2003
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“ Se os dois estudos estiverem certos
então pode ter sucedido que as
mulheres estudadas em ambos fossem
diferentes nalgum aspecto que os
investigadores não decifraram”.
Rossouw J, 2003
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WHI
(Women´s Health Initiative)
O que é que mudou? por
Manuel Neves-e-Castro XII Jornadas Minhotas de Ginecologia
Março 2007
e-mail: [email protected]
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NADA !
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NADA!
e por quê?...
porque só agora é que a comunidade científica
percebeu
o que é o WHI e
o que não é o WHI…
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desde há 4 anos…
a SPM soube e sabe ler o WHI !
e por isso se pode verificar que sempre estivemos na vanguarda da leitura correcta (que agora se confirma), nos concensos e artigos publicados !
http://www.spmenopausa.pt
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O que é que o WHI é ?
e
O que é que o WHI não é ?
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O WHI não foi desenhado para
estudar o efeito da THM
• em mulheres menopáusicas sintomáticas
• durante os primeiros 10 anos após a
menopausa
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WHI
• O WHI foi um estudo desenhado apenas para se verificar se a THM tinha efeitos protectores das doenças cardiovasculares:
- em mulheres sem os sintomas frequentes da pós-menopausa (afrontamentos, suores nocturnos, etc)
- com mais de 10 anos após a menopausa (a média de idades foi de 63 anos)
- submetidas a uma única terapêutica hormonal contínua (0,625mg de estrogéneos equinos conjugados e 2,5 mg de acetato de medroxiprogesterona) que não era ajustada em função da idade (até 80 anos!...) nem dos seus efeitos secundários !
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Por que motivo se fez o estudo
WHI?
Para determinar o efeito a longo prazo dos tratamentos hormonais na:
prevenção de
doenças cardíacas e
fracturas do colo do fémur, e
possíveis aumentos de risco para
cancro da mama e
cancro do cólon.
Mensagem do Presidente do Estudo WHI
www.hormone.org
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Press Statement IMS
The WHI study was not designed, and
therefore was not powered, to investigate the
consequences of hormone therapy (HT) in
women below 60 years of age. Therefore,
any attempt to present the results of the study
as indicating that HT may inflict damage to the
heart in general – a message that was accepted
by many medical societies and regulatory Authorities
is simply wrong and must be amended.
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WHI
Que vantagens trouxe?
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Uma chamada de atenção para
em termos gerais de THM
- se estudarem doses mais baixas do E e P
- se estudar o benefício/risco
a) das vias de administração
b) das moléculas de P e E usadas
c) da duração das THM
- se determinar qual a idade pós-menopáusica
segura para se iniciar uma THM
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A forma como se interpretaram
os resultados em termos de:
- Risco Absoluto (RA ou AR)
- Risco Relativo (RR ou RR)
- Risco Atribuível (RAt ou AtR)
- Número Necessário para Causar Dano
(NNCD ou NNH)
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A MENOPAUSA FOI ATACADA
POR UM
TERRORISTA HORMONAL !
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O Terrorista
Hormonal
![Page 34: A PRIMAVERA VEM AÍ… proferidas/Slides 2007/… · populações, e a confusão de riscos relativos com riscos absolutos! WHI and breast cancer Once again, it is apparent that the](https://reader034.vdocuments.site/reader034/viewer/2022042301/5ecc38521722067c72060701/html5/thumbnails/34.jpg)
O Terrorista
Hormonal
Quero tomar
TH !
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O Terrorista
Hormonal
Quero tomar
TH !
Mas alguns médicos dizem que
NÃO !...
![Page 36: A PRIMAVERA VEM AÍ… proferidas/Slides 2007/… · populações, e a confusão de riscos relativos com riscos absolutos! WHI and breast cancer Once again, it is apparent that the](https://reader034.vdocuments.site/reader034/viewer/2022042301/5ecc38521722067c72060701/html5/thumbnails/36.jpg)
Homem
woman
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Homem
Mulher
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WHI
O que se disse e ...
O que não se disse...
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Quais foram as conclusões do WHI no que se refere a:
cancro da mama?
doenças cardiovasculares?
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Efeito sobre o risco de
cancro da mama
WHI aumento do risco: RR 1.26 (CI 1.00-1.59); 26% aumento de risco
AR 0.38% vs 0.30% (ie, 38 vs 30 casos anualmente por
10.000 mulheres)
NÃO SIGNIFICATIVO !
HERS aumento do risco: RR 1.27 (CI 0.84-1.94); 27% aumento de risco
AR 0.59% vs 0.47% (ie, 59 vs 47 casos anualmente por
10.000 mulheres)
NÃO SIGNIFICATIVO !
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WHI (JAMA 2002;288:321-331)
Results: “the difference reaches “almost nominal
statistical significance” (i.e. not statistically different!)
Discussion: “the substantial risks for CVD and breast
cancer” (?!...) MNC/04
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Se os resultados do WHI se
calcularem, por ano, como
NNT NNH
DCV 1428
ACV 1250
TEV 588
Cancro da mama 1250
Cancro de Cólon 1667
Fracturas osteoporóticas 227
(total)
Neves-e-Castro M. Menopause in crisis post-Women’s Health Initiative? A
view based on personal clinical experience. Human Reproduction 2003;18:2512-8
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Women’s Health Initiative (WHI) per 1000 pts over 5 years
CHRT no HRT At Risk
Event
Coronary Heart Disease 17 13 +4
Stroke 13 9 +4
Pulmonary Embolism 8 4 +4
Invasive Breast Cancer 17 13 +4
Colorectal Cancer 5 8 -3
Hip Fracture 4 6 -2
Global Index 82 72
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Then, why all this
noise?...
Mainly because the conclusions of
recent trials were severely
misinterpreted by the medical
professionals, the media and by the
women, themselves
MNC/05
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Are Women in a crisis?
YES !
Why?
![Page 46: A PRIMAVERA VEM AÍ… proferidas/Slides 2007/… · populações, e a confusão de riscos relativos com riscos absolutos! WHI and breast cancer Once again, it is apparent that the](https://reader034.vdocuments.site/reader034/viewer/2022042301/5ecc38521722067c72060701/html5/thumbnails/46.jpg)
Because
We have a tendency to accept as valid
the headlines that circulate in the
media without having critically read the
full papers to which they refer
We are not able to explain to our
patients the meaning of those risks and
how small they are compared to other
risks to which they are expose MNC/05
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To begin with, and
in the light of the present evidence,
doctors and women should be
reassured that the suggested HT’s for
the relief of symptoms in the
menopause
are safe and very effective !
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Medicina Baseada na Evidência
e/ou
Evidência Baseada na Medicina
?
Manuel Neves-e-Castro
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Medicina Baseada na Evidência
e/ou
Medicina Baseada na Inteligência
?
Lucas Viana Machado
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Evidence informed practice (A Clínica Informada pela Evidência)
• It is clearly time to change “evidence based medicine” to “evidence informed practice”.
• I suggest the era of evidence informed rather than evidence based medicine has arrived
Glasziou P. Centre for Evidence-Based Medicine. University of
Oxford OX3 7LF. BMJ 2005;330:92
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Evidence-Based Medicine implies that recommendations should be limited to the
women for whom the studies are relevant.
March 2007 position statement of The North American
Menopause Society.Menopause 2007;14(2):1-17
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The practice of medicine is ultimately based on the interpretation at any one time of the entire body of evidence currently available.
March 2007 position statement of The North American Menopause
Society.Menopause 2007;14(2):1-17
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e … eis um exemplo de um
CONTRA-SENSO…
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Effects of conjugated Equine Estrogen in Postmenopausal Women
with Hysterectomy. JAMA, 2004;291:1701-1712
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Stroke
“In women 50-59 years not taking HT,
ischemic stroke is expected to occur in
3 out of 1000 women during 5 years.
Five years use of HT would yield 1
additional case of stroke/ 1000 women”
EMAS Statement; 2004.
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“Estamos afogados em informação
mas famintos de sabedoria”
John Naisbilt
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O que é que parece ter mudado na interpretação dos resultados de
WHI?
No que se refere a:
–Cancro da mama?
–Doenças cardiovasculares?
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O cérebro é como um
paraquedas…
ambos funcionam melhor
quando se abrem !
Lord Thomas Dewar
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A Mortalidade Cardiovascular
é o dobro da
Mortalidade por Cancro da Mama
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BENEFITS OF HORMONE THERAPY
In women less than 60 years old, recently menopausal and without prevalent cardiovascular disease, the initiation of HT does not cause early harm and may reduce cardiovascular morbidity and mortality.
Continuation of HT beyond the age of 60 should be decided as a part of the overall risk–benefit analysis.
IMS press statement, February 2007
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Clinica Cardiovascular da Mulher
• 13% das mulheres com idade superior a 45
anos teve uma síndrome coronária aguda
• 55% da mortalidade na mulher é devido a
doença cardiovascular (cardíaca, cerebral)
• As mulheres, representam 62% da
mortalidade por Insuficiência Cardíaca
• A doença coronária na mulher pré-menopausa
é menos prevalente, mantendo-se assim
durante 10 a 15 anos até aos 70 anos, altura
em que iguala o homem
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Hormone replacement therapy and risk
for coronary heart disease
Long-term HRT use is not associated
with increased risk for CHD in the CORA-study.
This research even supports the notion that HRT can
positively affect a number of risk factors like central
adiposity, insulin resistance and blood pressure.
HRT may even protect from CHD, but adverse lifestyle
habits like heavy smoking and a not sufficiently healthy
nutrition can offset the beneficial effects of HRT.
Windler E et al. Maturitas 2007 in press.
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Hormones and the Heart
1 in 3 women will die from coronary heart disease (CHD) in the USA.
1 in 25 women will die from breast cancer
Fitzpatrick LA. JCEM 2003;88(12):5609-10
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Causes of Death Among Women*
*Percentage of total deaths in 1999 among women aged 65 years and older.
Anderson RN. Natl Vital Stat Rep. 2001;49:1-13.
Heart Disease
Other Cancers
Other
Diabetes
Chronic Lower Respiratory
Disease
Cerebrovascular Disease
Breast Cancer 34%
10%
6%
3%
15%
28%
4%
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NNH / Year (Number Needed to Harm)
(the reciprocal of the AtR, the atributable risk)
Coronary Heart Disease
WHI (RR 1.29) 1428
HERS (RR 0.99) 5000
Breast Cancer
WHI (RR 1.26) 1250
HERS (RR 1.27) 833
MNC
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“Not everything that can
be counted counts;
and not everything that counts can be counted”
Albert Einstein
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“HRT is associated with a
35% reduction in mortality
for women who suffered
myocardial infarction”.
Shlipack MG, Angeja B, Go AS, et al Circulation 2001;104:2300-2304
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Doenças cardiovasculares (WHI )
O que estava oculto
- com terapêutica combinada (E+P)?
- com terapêutica só com E?
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Younger Women May Receive Heart Protection From
Estrogen Therapy
In women ages 50-59 who had undergone a
hysterectomy, a significant protective effect of estrogen treatment, when both primary (heart attacks and heart attack death) and secondary (coronary artery bypass surgery, angioplasty, confirmed angina pectoris) cardiac endpoints were considered.
Dr. S. Mitchell Harman, director and president of Phoenix-based
Kronos Longevity Research Institute (KLRI) in Archives of Internal Medicine 2006;106:357-363
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An update of the WHI Study !
WHI investigators reported (Feb 2006) a statistically significant (34%) lower risk for the combined endpoint of myocardial infarction (heart attack), coronary death, coronary revascularization and confirmed angina among women who were between the ages of 50 and 59 at the start of the study (RR 0.66; 95% CI 0.45-0.96).
Hsia J et al.Arch Intern Med 2006;166:357-363
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Hsia J, Langer RD, Manson J et al. Conjugated equine estrogens and coronary heart
disease. Arch Int Med 2006;166:357-65
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Hsia J, Langer RD, Manson J et al. Conjugated equine estrogens and coronary heart
disease. Arch Int Med 2006;166:357-65
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Hsia J, Langer RD, Manson J et al. Conjugated equine estrogens and coronary heart
disease. Arch Int Med 2006;166:357-65
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Press Statement IMS
The estrogen plus progestogen arm of the WHI
and the estrogen-alone arm actually showed that
HT does not
increase the risk of coronary heart disease in
the peri- and early menopause,
and may even carry beneficial effects.
Feb 2006
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Hormonas
e
Cancro da Mama
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Menopausal women and their
doctors are scared about the side
effects of HRT
mainly about breast cancer
MNC/05
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Cancro da mama (WHI)
o que concluiu o WHI ?
o que estava oculto no WHI ?
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WHI ...
A VERDADE !
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O fluxo da Verdade
corre através dos seus
canais de enganos ...
Rabindarath Tagore,1911
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POTENTIAL SERIOUS ADVERSE
EFFECTS OF HORMONE THERAPY
Women should be reassured that the possible risk of breast cancer associated with HT is small (less than 0.1% per annum).
IMS press statement, February 2007
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POTENTIAL SERIOUS ADVERSE
EFFECTS OF HORMONE THERAPY
Data from the WHI and Nurses’ Health Study suggest that long-term estrogen-only administration for 7 and 15 years, respectively, does not increase the risk of breast cancer in American women.
Recent European observational studies suggest that risk may increase after 5 years.
IMS press statement, February 2007
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Breast Cancer Risk in Postmenopausal
Women Using Estrogen-Only Therapy
Our nationwide study shows that the use of oral or transdermal estradiol for less than 5 years does not increase the risk of breast cancer, but such a risk appears with increasing duration of use in 2 to 3 extra cases of breast cancer per 1.000 women in 10 years of follow-up.
Lyytinen H et al. Obstetrics & Gynecology 2006;108(6):1354-1360
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The EMAS 2006/2007 update on
clinical recommendations on
postmenopausal hormone therapy
To conclude from these new publications they
suggest the absence of increased risk of breast cancer using estrogen only therapy after short periods of time (less than 10 year). An increased risk may exist thereafter, however.
Gompel A et al. Maturitas 2007;56(2);227-9
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Estrogen and progestogen use in peri-
and postmenopausal
women
In absolute terms, this increased risk was rare in the WHI, being 4 to 6 additional invasive cancers per 10,000 women per year who used EPT for 5 or more years.
March 2007 position statement of The North American Menopause Society.Menopause 2007;14(2):1-17
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Cancro da Mama WHI
C.I. (1.00 – 1.59)
ARC 0.30% / 10.000 / yr
ART 0.38% / 10.000 / yr
RR 1.26 (26%)
Attributable Risk = 8/10.000 / yr
= 1/ 1.250 / yr
NNH = 1.250 / yr
MNC/04
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Cancro da Mama HERS
C.I.(0,84-1.94)
ARC = 0,59% / 10.000 / yr
ART = 0,47% / 10.000 / yr
RR = 1.27 (27%)
Attributable Risk = 12 / 10.000 / yr
= 1 / 833 / yr
NNH = 833 / yr
MNC/04
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Breast cancer and the use of HRT
Considering 10.000 women on the combination HRT then for each year there would be:
Seven additional cases of heart attacks
Eight cases of stroke,
Eight cases of pulmonary embolus,
Eight cases of invasive breast cancer,
Six fewer cases of hip fractures
Baum M. The Breast 2005;14-178-80
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O Cancro da Mama
O risco de cancro da mama com os
E+P combinados contínuos é mínimo.
É necessário tratar 1250 mulheres
(NNH) durante 1 ano até que se
diagnostique 1 cancro da mama (o que
é equivalente ao risco relativo de 23%!)
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Cancro da Mama
O Risco Relativo aumentado de Cancro da Mama com os estrogénios mais progestagénios durante 5, 6 anos é comparável ao aumento de risco de Cancro da Mama para uma mulher que consome uma bebida alcoólica por dia ou que tem um Indice de Massa Corporal de 24, em comparação com 22.
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It must be emphasized that we are
talking about an increased incidence of
the disease, which does not
automatically translate into an increase
in deaths from the disease.
Baum M. The Breast 2005;14:178-80
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Almost 2/3 of women now diagnosed with
breast cancer are likely to survive at least 20
years • Cancer Research UK researchers estimate that 64%
of women newly diagnosed with breast cancer in England and Wales will live for at least 20 years - compared with 44% in the early 1990s.
• More than 7 out of 10 women (72%) are now predicted to survive for at least 10 years, compared with 54% diagnosed in the early 1990s.
• Survival in women aged 50 to 69 - the age group in which breast cancer is most commonly diagnosed - was even better, with 80% predicted to live for at least 10 years while 72% survived to at least 20 years.
Prof. Michel Coleman, London School of Hygiene and Tropical Medicine told reports; Oct.10, 2005.
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Source: Eurocare study
53.6 40.5 49.2 51.0 84.3 76.1 65.4 EUROPE
56.7 43.5 55.0 56.3 91.0 80.0 67.0 Switzerland
57.6 42.5 52.2 54.4 90.6 82.6 67.4 Sweden
57.1 43.9 55.0 55.8 89.8 78.0 65.5 Spain
47.0 31.2 34.8 38.8 70.0 67.4 48.8 Slovenia
N/A N/A 49.0 43.5 68.9 71.9 44.0 Portugal
40.5 25.2 26.3 28.7 57.9 63.1 38.6 Poland
54.9 40.0 51.4 53.6 88.4 77.2 62.1 Norway
55.7 42.7 51.9 54.0 87.7 78.2 68.4 Netherlands
N/A N/A 35.9 53.3 65.0 74.8 39.4 Malta
55.6 41.2 51.2 52.1 82.5 80.6 63.9 Italy
N/A N/A 45.9 55.2 90.9 79.6 76.2 Iceland
55.6 44.1 50.5 54.5 89.9 75.4 75.9 Germany
57.9 44.5 55.9 58.7 85.3 81.3 75.2 France
55.8 41.4 54.0 52.7 84.0 81.4 66.5 Finland
51.2 33.5 43.2 47.6 88.0 74.9 41.5 Denmark
46.0 32.3 38.1 36.4 78.1 64.0 50.1 Czech Rep.
57.9 47.5 N/A 58.4 88.2 75.4 83.6 Austria
47.3 34.7 40.1 36.5 79.1 69.5 48.8 WALES
49.5 35.6 45.3 47.2 90.1 72.3 53.6 SCOTLAND
50.8 37.1 45.7 46.2 85.6 73.6 53.8 ENGLAND
All (F) All (M) Colon (M) Colon (F) Skin* Breast Prostate
% of patients alive five years after diagnosis
European Cancer Survival
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Extended use of estrogen for
10 years increases risks by 0,5%, and by
15 years increases risks by 0,9%
but..
upon cessation of HRT, the relative risk quickly returns to 1.0 !
Coombs N J, Taylor R, Wilcken N. and Boyages J. BMJ 2005;331:347-
349
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Breast Cancer
• The diagnosis of a breast cancer after the initiation of a HRT (with a duration of less than 5 years) is only a proof of its growth stimulatory effect (not of its carcinogenic effect)
• Therefore, the reversal of the risk to 1 after the cessation of HRT confirms again only its growth promoting effect and denies a carcinogenic effect.
Dietel M., Lewis MA. and Shapiro S. Human Reproduction 2005;20:2052-60
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Breast Cancer
• The doubling time of an initial cancer cell,
up to the diagnosis of a resultant 1cm
tumor, is most likely greater than 10 years.
• This is why many dormant cancer cells
may exist in a “normal” breast ! MNC/05
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Occult Breast Cancer
Clinically occult in situ
BC’s are frequent in
young and middle-aged
women. Nielsen M et al-Br J Cancer 1987;56:814-9
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Occult Breast Cancer
Breast malignancy was
found in 22 women
(20%)
Nielsen M et al-Br J Cancer 1987;56:814-9
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Thus…
• Mammographies give more false
negative than false positive results !
• A “normal” mammography does not
exclude the presence of cancer cells
that may “explode” a few months later…
MNC/05
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Estrogen replacement therapy in
patients with early breast cancer
The mortality rates from breast cancer for
the ERT users was 4.28% compared with
22.3% in the nonusers.
Natrajan PK and Gambrell RD. Am J Obstet Gynecol 2002;187:289-95
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HRT in Breast Cancer Survivors: results:Matched Analysis
174 breast cancer cases taking estrogen
matched 4:1 controls with cancer not taking Estrogen.
Cases
(ERT/HRT)
Controls
(no ERT/HRT) recurrence 17/1000 30/1000
Br cancer
deaths
5/1000 16/1000
Total deaths 16/1000 30/1000
O’Meara et al, JNCI 2001
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“Recurrent breast cancer was
found in 9% of HRT users and
15% of nonuser”.
O’Meara ES et al.JNCI 2001;93:754-761
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Mortality following development of
breast cancer while using
oestrogen or oestrogen plus progestin:
W Chen, DB Petitti and AM Geiger.
British Journal of Cancer 2005;93:392–398
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This study explored survival after
exposure to oestrogen or oestrogen
plus progestin at or in the year prior to
breast cancer diagnosis
oestrogen plus progestin users
had lower all-cause mortality
and breast cancer mortality
Chen W, Petitti DB and Geiger AM. British Journal of Cancer
2005; 93:392-398
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Breast cancer survival after hormone
exposure
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Overall survival after hormone
exposure
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Breast Cancer
Estrogens and Progestagens
• No significant increases in risk was observed in users of estrogens used alone (RR 1.1; 95% CI=0.8-1.6) compared with non exposed women but it was greater in combination with oral progestagens (RR 1.3; CI 1.1-1.5)
• The risk was significantly greater (p <0.001)with HRT containing synthetic progestagens (RR 1.69; CI 1.5-1.9) than with HRT containing micronized progesterone (RR 1.0; CI 0.83-1.22)
Fournier A et al. Int J Cancer 2005;114:448-454
Fournier A et al. Breast Cancer Res Treat.2007,Feb 27 in press
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Reduced hormone therapy use might be cause of steep decline in
breast cancer cases
A report presented December 14, 2006, at the 29th San Antonio Breast Cancer Symposium in Houston shows a 7% drop in US breast cancer rates. The analysis suggests a link between the decline in breast cancer and hormone therapy (HT) use.
December 2006 position statement of The North American Menopause Society
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Recent declines in hormone therapy
utilization and breast cancer incidence:
clinical and population-based evidence
Clarke CA et all. Journal of Clinical Oncology 2006;24(33):e49-50
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Reduced hormone therapy use might be cause of steep decline in
breast cancer cases
Greatest decrease in breast cancer was in the number of ER+/PR+ breast cancers. There was little change in other breast cancers. The greatest decrease also occurred in the women aged 50 to 69, those most likely to be using HT.
Gass M. F.NAMS special issue released December 20,2006
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Reduced hormone therapy use might be cause of steep decline in
breast cancer cases
Their data most likely reflect existing cancers just below the detection limit in 2002 that slowed or stopped their growing.
December 2006 position statement of The North American Menopause Society
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Reduced hormone therapy use might be cause of steep decline in
breast cancer cases
Another finding that is consistent with an effect
on preexisting tumors is the fact that not a single
study thus far has reported a risk increase for
noninvasive disease. If HT were initiating
(causing) new tumor formation, one would
expect to see an increase in in situ disease.
December 2006 position statement of The North American Menopause Society
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Analisemos então os
Riscos
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Há riscos?
É indispensável que seja dada
informação sobre as diferenças entre
riscos relativos e riscos absolutos uma
vez que os primeiros são a principal causa
de desinformação e alarmismo, sendo os
favoritos dos media…
MNC/05
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E então ...
Como saber
Qual é a verdade
e
Qual não é ?
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Explain the risks in a way that is
understandable....
Compare the risks of HRT with other
better known risks....
MNC/05
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Increase
incidence
Relative
risk Risk factor
+ 20% 1 : 1.2 Physical activity – activate : inactive
+ 60% 1 : 1.6 Serum lipids – normal : raised
+ 30% 1 : 1.3 Alcohol consumption-none:≥20 g daily
+ 30% 1 : 1.3 Hormone replacement-never:5 or
more yrs
+ 10% 1 : 1.1 Oral contraceptives – never user:ever user
+ 40% 1 : 1.4 Age at first birth – 20 yrs : 35 yrs
+ 30% 1 : 1.3 Parity – multiparous : nulliparous
+ 30% 1 : 1.3 Age at menarche – 14 yrs: 11 yrs
+ 100% 1 : 2.0 Age at menopause - 42yrs : 52 yrs
+ 150% 1 : 2.5 Body weight-normal weight : obesity
BREAST CANCER
R. Santen, 2004
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Exemplos de Risco Absoluto, Risco Relativo, Risco Atribuível
• Se comprar um número da lotaria, terá 1 oportunidade em um milhão de ganhar. (risco absoluto).
• Se comprar cinco números da lotaria, a oportunidade será cinco vezes maior, ou simplesmente 5 em um milhão.
• As oportunidades de ganhar aumentam 5 vezes, (risco relativo).
• A diferença entre os dois riscos é de 4 em um milhão (risco atribuível)
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Risco atribuível, ou de excesso (que é o mais importante para a clínica)
A diferença entre o risco de
base, subjacente, e o risco após
receber TH é denominada
risco atribuível, ou de excesso.
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Não confunda…
Risco Relativo com
Risco Absoluto !
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Intervalo de Confiança (C.I.)
Um C.I. de 95% significa que há 95% de
probabilidades de que os “valores
verdadeiros” da população estejam entre
os dois limites.
Se o C.I. cruza a linha de “diferença
nula” ao ponto de que o benefício se
converta num risco (i.e.1), pode concluir-
se que os resultados não são
estatísticamente significativos.
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Manson J et al. Menopause2006;13(1):139.147
Linha de diferença nula
Linha de diferença nula Linha de diferença nula
Linha de diferença nula
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Efeito sobre o risco de
cancro da mama
WHI aumento do risco: RR 1.26 (CI 1.00-1.59); 26% aumento de risco
AR 0.38% vs 0.30% (ie, 38 vs 30 casos anualmente por
10.000 mulheres)
NÃO SIGNIFICATIVO !
HERS aumento do risco: RR 1.27 (CI 0.84-1.94); 27% aumento de risco
AR 0.59% vs 0.47% (ie, 59 vs 47 casos anualmente por
10.000 mulheres)
NÃO SIGNIFICATIVO !
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Ao ler estudos
Epidemiológicos POR FAVOR !
Não leiam só os títulos…
Não leiam só os resumos…
Há que ler os artigos completos!!
Devemos ser críticos!
Devemos construir os nossos próprios
conceitos!
MNC
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Assessment of the
understanding of the risks and
benefits of hormone
replacement therapy (HRT) in
primary care physicians
Williams RS, Christie D and Sistrom C.
Am J. Obstet Gynecol 2005;193:551-6
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Respondents that overestimate the
increase or decrease in risk were making
the error of confusing relative risk with
absolute risk difference.
There is a great need for physician
education about the attributable
risks and benefits of HRT MNC/05
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Strategies to help patients
understand risks
Paling J. BMJ 2003;327:745-8
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Risks of women medicated with E+P (5.2 years)
women
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Risks of women medicated with E only (6.8 years)
women
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Risks of Breast Cancer
according to different factors
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Podem reduzir-se
os efeitos secundários ?
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There are no really “safe”
biological active drugs...
There are only “safe” physicians !
Kaminetzy HA 1993
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“Aquele que aprende
mas não pensa
está perdido.
O que pensa mas não aprende
é perigoso…
Confucius
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mas…
se aprendermos e
pensarmos…
nem estaremos perdidos
nem seremos perigosos
para as nossas doentes pós-
menopáusicas
Wenger NK. Am J Geriatr Cardiol 2000;9:204-9
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A práctica Clínica…
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Conhecer
a doença que uma mulher tem
é tão importante como
conhecer
a mulher que tem a doença
William Osler
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Os médicos devem dar a
informação
a mulher deve acatar a
sua decisão
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Os médicos devem dar a
informação
a mulher deve fazer o
que decidiu
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Qual é o melhor tratamento ? • As necessidades e preferências da mulher são
decisivas baseadas no conselho do médico
• Não deve esquecer-se que apesar de haver muitos tratamentos hormonais disponíveis não são no entanto indispensáveis
• Os médicos têm o dever de dar a sua melhor informação independente às suas doentes de modo a que elas possam fazer as escolhas acertadas e assim aderir aos tratamentos
• A mulher é quem toma a decisão se o médico não vir contraindicações
• Portanto o melhor tratamento é aquele que a mulher escolher
MNC
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I personally believe that for the healthy
early post menopausal woman the long term
HT’s, other than relieving vasomotor
symptoms, may play an important role in
improving QoL and in the prevention of
CVD, osteoporosis and Alzheimer, under
surveillance.
Systemic (parenteral) estrogens, added when needed to vaginal progesterone or progestagen loaded IUD’s, may be very beneficial, largely overpassing minimal risks.
MNC/05
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The conclusions of the WHI trial suggest
that the “safe “ woman (NNH between 600-
1000 women) to initiate HT is
- between 50-59 years of age
- with vasomotor symptoms
- less than 10 years after the menopause
- being treated with statins
- with a good lipid profile and
- with a Body Mass Index >25
Neves-e-Castro M. Human Reproduction 2003;18:2512-2518
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E...
que tal com os
produtos
“naturais” ?...
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Evitar que uma Mulher
beneficie de uma correcta terapêutica hormonal
na pós-menopausa
pelo receio de raros efeitos secundários
não me parece ser uma Medicina satisfatória…
M.Neves-e-Castro, 2000
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O que é que temos
aprendido sobre a
Menopausa ?
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“Each time we learn something new,
the astonishment comes from the
recognition that we were wrong before.
In truth, whenever we discover a new fact, it involves the elimination of old ones.
WE ARE ALWAYS, as it turns out, fundamentally IN ERROR.”
Lewis Thomas English Biologist (1913-1993)
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As convicções são inimigos
mais perigosos da verdade do
que as mentiras
Friedrich Wilhelm Nietzsche
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What has been learned from the
major observational studies and
clinical trials?
the first lesson
systematically administered progestagens may in part suppress some of the beneficial effects of estrogens and may also slightly increase the risk of breast cancer after treatments with duration greater than five years.
MNC/05
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What has been learned from the
major observational studies and
clinical trials?
the second lesson
estrogens, when given alone to
histerectomized women, did not appear to
minimally affect the risk for breast cancer
when compared with controls
MNC/05
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What has been learned from the
major observational studies and
clinical trials?
the third lesson
Metabolic effects of estrogens and
progestagens, as a whole, can differ
depending on the route of administration, i.e.
oral vs. parentheral, and on the combination of
both, in a sequential regimen or in continuous
combined administration. MNC/05
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What has been learned from the
major observational studies and
clinical trials?
the fourth lesson
Hormonal treatments are the first
choice for vasomotor symptom relief as
long as they are needed (on and off
assessment). They should not be used for
the secondary prevention of CVD, when
atheroma plaques are already present. MNC/05
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What has been learned from the
major observational studies and
clinical trials?
the fourth lesson (cont.)
Conversely, they may protect from CVD if started early during the transition into the post menopause.
Hormonal treatments are preventive of osteopenia and osteoporosis at any stage in life
MNC/05
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The take-home message is:
(1)
Prescribe postmenopausal hormonal treatments when clinically indicated, if not contraindicated!
MNC/02
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The take-home message is:
(2)
The prescription of long-term hormonal treatments must depend always on a benefit/risk analysis in comparison with other non-hormonal medications and strategies. MNC/02
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The take-home message is:
(3)
No answers from ongoing clinical trials are indispensable to practice today a good Medicine !
MNC/02
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BENEFITS OF HORMONE THERAPY
• HT remains the most effective therapy for vasomotor and estrogen-deficient urogenital symptoms.
• Quality of life and sexuality are key factors to be considered in the management of the aging individual.
• The administration of individualized HT (including androgenic preparations when appropriate) improves both sexuality and overall quality of life.
IMS press statement, February 2007
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Recommendations on postmenopausal hormone therapy
• There are no reasons to place mandatory limitations on the length of treatment.
• Whether or not to continue therapy should be decided at the discretion of the well-informed hormone user and her health professional, dependent upon the specific goals and an objective estimation of benefits and an objective estimation of benefits and risks.
IMS press statement, February 2007
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IMS reaction to recent breast cancer data
The use of hormones in early menopause and up to age 60 years has a very minor potential for harm, but may carry substantial benefits. Women should decide annually if they wish to continue
with treatment after consultation with their caregivers.
Press statement of IMS.December 19, 2006.
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The new American way …
or …
a 180º rotation ! … MNC/05
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NAMS position statement on
estrogen and progestagen use in
peri-and postmenopausal women
No single trial should be used to set
public health policy. The practice of
medicine must ultimately be based on the
interpretation of the entire body of
evidence currently available, given that
there will never be adequate clinical
trials to cover all populations,
eventualities, and regimens.
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NAMS position statement on
estrogen and progestagen use in
peri-and postmenopausal women
Place no limit on ET/EPT treatment
duration, provided it is consistent with
treatment goals; if monitored regularly, no
stipulation is made regarding when to
reduce or stop therapy
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Key Points:
NAMS March 2007
Position Statement
on Hormone Therapy
The North American Menopause Society. Estrogen and progestogen use in peri- and postmenopausal women: March 2007 position statement of The North American Menopause Society. Menopause 2007; In press.
Copyright 2007
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HT and Vasomotor Symptoms
Treatment of moderate to severe vasomotor symptoms (ie, hot flashes, night sweats) remains primary indication for systemic ET/EPT
With few exceptions, every systemic ET/EPT product is government approved for this indication
Copyright 2007 NAMS position statement. Menopause 2007.
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EPT and Breast Cancer Risk
Breast cancer risk increases with EPT use beyond 5 years
Increased absolute risk in WHI is viewed as rare (4-6 additional invasive cancers/10,000 women/yr when use EPT for ≥5 yrs)
(cont’d)
Copyright 2007 NAMS position statement. Menopause 2007.
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ET and Breast Cancer Risk (cont’d)
Women in WHI’s ET arm had 8 fewer cases of invasive breast cancer/10,000 women/yr of ET use
Available evidence suggests ET for <5 yr has little breast cancer risk impact
Limited observational data suggest ET for >15 yr may increase risk
Copyright 2007 NAMS position statement. Menopause 2007.
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3rd International Symposium of the
Portuguese Menopause Society In Celebration of the World Menopause Day
The Transatlantic Controversies - The State of the Art October 23, 2004 Fundação Engº António Almeida Oporto – Portugal
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A equipe U.S.A.
1 2 3 4
1. R. Chlebowski 2.J.Rossow 3. R. Lobo 4. Th.Clarkson
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A equipe Europeia
1. D.Barlow 2. H. Kuhl 4.P.Kenemans 4. A.Pines
1 2 3 4
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As estrelas da Menopausa !
1 2 3 4
5 6 7 8 9 10 11 12
13
14 15
1.D.Barlow, 2.H.Kuhl, 3.P.Kenemans, 4.A.Pines, 5 F.Al-Azzawi, 6.J.Rossouw,
7.J.Stevenson, 8.R.Chlebowski, 9.S.Palacios, 10.Th.Clarkson, 11.M.Sousa,
12.M.Neves-e-Castro, 13.A.Genazzani, 14.J.Calaf, 15.R.Lobo
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3rd International Symposium of the
Portuguese Menopause Society In Celebration of the World Menopause Day
The Transatla Algumas das
NCLUSÕES ntic Controversies - The State of
the Art October 23, 2004 Fundação Engº António Almeida Oporto – Portugal
CONCLUSÃO
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KEEPS
Kronos Early Estrogen Prevention Study
estudo em curso em mulheres sintomáticas até 10 anos após a menopausa
Rexrode K and Manson J. Circulation 2007;115:820-2
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ELITE
Early vs. Late Intervention Trial with Estradiol
estudo em curso
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Não há melhor tratamento para
os sintomas do climatério do
que os tratamentos hormonais
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•Se és um clínico tens que acreditar que
sabes o que ajuda os teus doentes.
Caso contrário não podes nem aconselhar
nem receitar.
•Porém, se és um cientista tens que ter incertezas: um cientista que deixa de fazer perguntas é um mau cientista…
George Pickering;”Physician and scientist” Br.Med.J. 1964;2:1615-9
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UMA MULHER
no Outono da sua vida
merece um Verão de S.Martinho
em vez de um triste Inverno
Greenblatt
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Como
concluir ?...
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Este não é o fim, nem sequer o princípio do fim,
mas talvez seja
o fim do princípio ...
Winston Churchill
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Esperando por mais...
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IV Simpósio Internacional
da Sociedade Portuguesa de Menopausa
The Improvement of
Health and Disease Prevention
for the Mid-aged Woman:
The State of the Art
20 Outubro 2007
Lisboa . Portugal
Pestana Palace Hotel
visite o nosso website www.spmenopausa.pt em 4th International Symposium
Sociedade Portuguesa de Menopausa
Av. Almirante Reis nº 62 – 1º Esq.
1150-020 Lisboa - Portugal
Telf: (+351) 21 3174356 – (+351) 93 6016522 Fax: (+351) 21 3156658
e.mail: [email protected]
Hotel venue:
Pestana Palace – Hotel e Monumento Nacional
www.pestana.com
Participantes, até 31 Maio 2007:
Sócios da SPM e EMAS: € 200,00
Não - Sócios: € 250,00
Participantes, a partir de 31 Maio 2007:
Sócios da SPM e EMAS: € 250,00
Não - Sócios: € 300,00
Inscrições
Para mais informação:
que vão encontrar aqui !
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IV Simpósio Internacional
da Sociedade Portuguesa de Menopausa Mário de Sousa – President e da SPM
Lisboa . Portugal, Pestana Palace Hotel, 20 Outubro 2007
The Improvement of Health and Disease
Prevention for the Mid-aged Woman:
The State of the Art Manuel Neves-e-Castro – Symposium Chairman
Speakers (confirmados):
D. Sturdee (UK): “The hot Flush”;
P.van der Weijer (NL): “Risks of HRT in the 50-59 year age group”;
R. Lobo (USA): “Metabolic Syndrome after menopause and the
role of hormones”
Anne Gompel (FR): “Hyperinsulinemia, obesity and the risk of breast
cancer”;
D. Herrington (USA): “Postmenopausal heart disease prevention: Why
the cardiologists have it all wrong?
J.C.Gallagher (USA): “The role of rank L in postmenopausal bone loss
and arthritis: Treatment options”;
F. Naftolin (USA): “Molecular factors in maintenance of the pelvic
floor in menopausal women”;
C.Castelo-Branco (SP): “Definition and diagnosis of sexuality in the 21rst
century: New horizons”
Chairmen: Lucas Viana Machado (Brasil) and Morris Notelovitz (USA) (Todas as sessões serão em Inglês)
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terminei !... e…
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este... já pode acordar…
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Obrigado …
…por não terem ressonado !