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2015 NIH SBIR Phase I Award : 1R43OD020163
Ultra-Fast Cooling Method for Cell Cryopreservation
Peter KoulenCryoCrate LLCXu Han PhD
UMKC
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Cryobiology and cryopreservation
Opportunity: cells as emerging products
19841949Christopher Polge
Greg Fahy
Retrospect for cell cryopreservation
Cryopreservation through traditional approaches
Global market > $100B market, 25%/yr increase
Slow Freezing
Vitrification
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Cell types challenging traditional cryopreservation approaches
Human ESCs and iPSCs
Lipid rich cellsAnimal sperm
Human MII oocytesHuman corneal endothelium and RPE
Mature neurons
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Value proposition
Significantly improved cell survival Automatic sample handling and safe operation Compatible with our innovative medium for -80oC
storage
REPLACES
~$ 100K, clean and safe ~$ 1 M, numerous safety and maintenance issues
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Business model and marketing strategy
Reference:Global biobank (biospecimen/ biorepository/ biopreservation) market for equipment & media – trends & forecast to 2017,
By MarketsandMarkets, 2014
Global market for cryostorage device:
$3.5 B, 18% yearly increase
Global market for cryostorage medium:
$ 463M, 15% yearly increase
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IP and licensing
US Appl. No. 14/482,692 US Appl. No.12/374,622
New IP: Device and
consumables
NIH SBIR Phase I Award
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Launch team and networking
Dr. Peter Koulen• Co-PI • Professor, chair in Vision
Research at UMKC• Director of Basic
Research UMKC Vision Research Center• Neurologist,
ophthalmologist
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Financial projections
With MU’s SupportWithout MU’s Support
• MU labs as early adopters
• MU GMP facilities
• MU business school cooperation