Download - 2-1. CAKUT. Svetlana Paunova (eng)
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Genetics and congenital abnormalities
of kidney and urinary tract
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М.N. (male), 3 мо
Yong healthy parents 2-nd normal pregnancy Normal perinatal history BBW – 3450 g, length – 52 sm Brest feeding Normal physical and mental development BW 3 mo – 5600 г. (normal)
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MEDICAL HISTORY
Routine examination before DTP immunization
WBC (blood count) 21 th. ESR 65 mm/h Admitted to a hospital with Ds: acute otitis?
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ADMISSION STATUS
No fever Irritated No appetite Pale skin with grey shade No other disorders Belly - round form, abdominal mass
about 8 x 10 cm on the left side
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BLOOD COUNT IN ADMITION
Date 06.03.08
WBC 28,0
RBC 4,03
HB 103
HT 29,1
PLT 759
SC 2
SN 42
E 1
MON 7
LYMF 43
ESR 59
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BIOCHEMICAL BLOOD ANALYSIS
Seromucoid - 0,352 (N 0,100 – 0,200) CRP – 0,120 (N до 0,001 г/л) АSLO 1:500 (N 1:250) Other - normal
CMV IG M +
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URINE TESTS
Clinical urine analysis(twice)- N
Bacteriuria- negative
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Вставить картинку!!!!!!
Renal US Right kidney 74 х 30 х 33
mm, parenchyma layer 7 mm
Left kidney 96 х 53 х 57 mm (N up do 50 mm)
Pelvis sinus left- 26mm, calic- up to 19 mm
The cortex layer - lots of fluid inclusions (d) up to 22 mm.
Iliac dystopia of left kidney
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INTRAVENOUS UROGRAPHY
Left kidney shadow is approximately absent.
1,5-hour picture left side – several low contrasted round shadows d= 0,7 - 2,0 sm, enlarged calyces.
Left kidney function non significant. Conclusion: left hydronephrosis with severe
function reduction
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TREATMENT Ceftriaxone 400 mg/24h i/m Detoxic therapy Syndromal therapy
A serious condition (depressed appetite has sharply reduced, the skin earthy shades, weight negative dynamics, ESR 52 mm/h, neutrophilia)
septicemia !!!
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LEFTTRANSCUTANEOUS NEPHROSTOMY
During the operation received 150.0 ml of cloudy urine with lots of lush green pus
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POSTOPERATIVE TREATMENT
A/b treatment – 14 days Immunocorrection Detoxic therapy
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Общий ан. крови
(контроль)
Date 06.03.08
WBC 11,8 (28,0)
RBC 3,58
HB 98 (103)
HT 26
PLT 413
SC 1 (2)
SN 20 (42)
E 4
MON 2
LYMF 73 (43)
ESR 16 (59)
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RENAL US (FOLLOW-UP)
Left kidney 75 х 29 х 27мм
(96 х 53 х 57)
Calyces (left kidney) up to 10 mm (19мм)
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25 DAYS AFTER NEPHROSTOMY
No fever Feeling good (gay, active, interested
in toys) Appetite satisfied (requests to eat) Encreases weight
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FOR FUTURE
Surgical correction of urodynamics
Good prognosis
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CONCLUSION
Accidentally revealed gross pathology of the kidney
No urinary syndrome The rapid development of
urosepticemia
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CAKUT
Congenital anomalies of kidney and urinary tract
1:500 live births 1:2000 neonatal deaths
Loane M, Dolk H, Kelly A, et al Paper 4: EUROCAT statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europe.
Birth Defects Res A Clin Mol Teratol 2011;91 Suppl 1:S31-S43. Anomalies of UT in 10% of relatives of
patients with CAKUT (usually asymptomatic!) Winyard P, Chitty LS. Dysplastic kidneys. Semin Fetal Neonatal Med 2008;13:142-151.
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Jeffery Fletcher, Stephen McDonald , Stephen I. Alexander, on behalf of the Australian and New Zealand Pediatric Nephrology Association (ANZPNA)
Prevalence of genetic renal disease in childrenPediatr Nephrol, 2012
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СAKUT
KIDNEY URINARY TRACT
Renal agenesia- renal absence Дисплазия почки- kidney contains an
undifferentiated tissue and can be small (APLASIA) and extended due to cysts (cystic dysplasia or MCDK)
Hypoplasia of kidney (kidney contains normal nefrons, but few of them, or they are big-oligomeganefronia)
The doubling of the collective system (upper part is dysplastic, combined with ureteral obstruction, lower-VUR)
Horseshoe kidney
Агенезия- отсутствие «треугольника»
PUJ stenosis Megaurether Post. Urethral
valve VUR
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Stages of renal branching morphogenesis and nephron formation.
Shah M M et al. Development 2004;131:1449-1462
35-37 day of gestation
(A) Stages of renal branching morphogenesis and nephron formation. Ureteric bud (UB)
outgrowth from the Wolffian duct is induced by signals from the metanephric mesenchyme
(MM) (A). (B,C) Invasion of the MM by the UB is followed by iterative branching of the UB and
elongation of UB stalks. (D) At the tips of the branches, the epithelium induces the
mesenchyme to form pre-tubular aggregates, which are stimulated to undergo mesenchymal to epithelial transformation (E,F) through the
formation of comma-shaped (E) and S-shaped (F) bodies to form components of the nephron (G): renal tubules (proximal and distal) and the
epithelial component of the glomerulus. (B) Nephron endowment is thought to be largely
determined through branching of the UB. (Left) The UB adopts a strategy of lateral branching
followed by bifurcation of a stem into two daughter branches (terminal bifid branching) to
form the collecting system of the kidney. Nephrons are induced at UB tips but are also
formed around the stem of elongating branches during the later branching iterations (arcades) and late-phase lateral branching.
(Right) The segments of the collecting system proximal to the ureter (the renal pelvis and calyces) are formed from early branching
segments of the UB that have dilated.
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An overview of the major signaling pathways involved in ureteric epithelial branching.
Little M H , and McMahon A P Cold Spring Harb Perspect Biol 2012;4:a008300©2012 by Cold Spring Harbor Laboratory Press
Utip – urethral epithelium
CapM- mesenchimal tissue
Gdnf, Vegfa, Hgf, Fgf10 – growth factorsAgt- angiotensinogen
Ret/Gfrα1, Kdr, Met, Fgfr2, Egfr, Agtr1/2 - receptor tyrosine kinase
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Nature Rev Genetics 3, 533-43, 2002 Coordinating early kidney development: lessons from gene targeting
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Ontogenic mechanisms involved in the formation of CAKUT. A primary defect in either the growing ureter or the differentiating metanephric blastema can cause both ureter and kidney.
POPE J C et al. JASN 1999;10:2018-2028
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Gene CAKUT phenotype Type of mutations identifieda Mutation detection rate in unrelated cases
BMP4 Renal hypoplasia Missense 5/250 (2%)
EYA1 Renal hypoplasia Insertion, deletion 2/99 (2%)
GDNF Renal agenesis, renal dysplasia Missense 1/33 (3%)
GFRA1 Renal agenesis, renal dysplasia None 0/33 (0%)
HNF1βRenal agenesis, renal hypoplasia,
renal dysplasiaDeletion, splice site
8/99 (8%), 75/377 (20%), 5/50 (10%), 25/80 (31%)
HOXA11/HOXD11Renal agenesis, renal hypoplasia,
renal dysplasiaNone 0/59 (0%)
PAX2 Renal hypoplasia, renal dysplasia Insertion, deletion, splice site, stop 6/99 (6%), 2/20 (10%), respectively
RET Renal agenesis, renal dysplasia Missense, stop 9/33 (27%), 7/101 (7%)
ROBO2 VUR Missense 6/95 (6%)
SALL1 Renal hypoplasia Deletion 1/99 (1%)
SIX1 Renal hypoplasia Missense 1/99 (1%)
SIX2 Renal hypoplasia Missense 5/250 (2%)
SOX17 VUR, UPJ obstruction Missense, insertion 6/178 (3%)
UMOD Complete CAKUT spectrum None 0/96 (0%)
UPK3ARenal agenesis, renal dysplasia,
renal hypoplasia, PUV, VURMissense 0/76 (0%), 2/170 (1%), 4/17 (24%)
Genetics and CAKUT
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LocusCAKUT phenotype Model
Parametric (H)LOD score NPL (P-value)
1p13 VURAutosomal dominant 3.16 5.76 (0.0002)
1p32–33 Renal agenesis, renal hypoplasia
Autosomal dominant
3.50 5.30 (0.00015)
1q41–44 and 11p11
PUV and Prune Belly syndrome
Autosomal recessive
3.01 –
2q37 VURNon-
parametric – 4.10 (0.001)
6p21 Hydronephrosis, UPJ obstruction
Autosomal dominant
3.09 –
8q24Renal agenesis,
VURAutosomal recessive 4.20 –
12p11–q13 VURAutosomal recessive 3.60 4.00 (0.0001)
Novel perspectives for investigating congenital anomalies of the kidney and urinary tract (CAKUT)
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Kerecuk L et al. (2008) Renal tract malformations: perspectives for nephrologistsNat Clin Pract Nephrol doi:10.1038/ncpneph0807
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Effect of Drugs on Renal Development
Effect of Drugs on Renal Development Michiel F. Schreuder, CJASN January 2011 vol. 6 no. 1 212-217
DrugEffect of Maternal Treatment
during Pregnancy on Offspring Kidney Development
Effect of Treatment during Postnatal Kidney Development
AminoglycosidesTubular alterations (16), low nephron number (17–19)
Tubular damage (21), low nephron number (19)
Cyclosporin A Low nephron number (22)
Prostaglandin synthetase inhibitors
Tubular alterations (21), similar nephron number (28)
Glomerular and tubular injury (21), similar nephron number (21,26,27)
ACEIs/ARBs Renal insufficiency (31)Atrophy of the renal papilla, tubular alterations (32), low nephron number (33)
DexamethasoneAltered tubular transporters (36,37), low nephron number (5), similar nephron number (38)
Low nephron number (5,35)
Furosemide Renal concentrating defect (40) —
Antiepileptic drugsMore congenital malformations, specifically MCDK (44)
—
Mycophenolate mofetil Renal agenesis/ectopia (45,46) —
AdriamycinBladder agenesis, hydronephrosis (48)
—
Cyclophosphamide Hydro(uretero)nephrosis (49) —
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РАЗВИТИЕ ПОЧКИ (В НОРМЕ И ПАТОЛОГИИ)
Larissa Kerecuk, Michiel F Schreuder and Adrian S Woolf, Renal tract malformations: perspectives for nephrologists Nature Clinical Practice Nephrology (2008) 4, 312-325,
Гипоплазия почки – меньше рядов нефронов при сохранной экскреторной функцииКистозная дисплазия- порочные канальца, маленькие кисты, остаточная экскреторная функция, лоханка не измененаМКДП- нет функции, нет собирательной системыАплазия-нет первичного роста ткани
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Renal agenesia
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HORSESHOE KIDNEY
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Hypoplasia of kidney
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MULTICYSTIC DISPLASIA
John J. Bissler, Brian J. Siroky and Hong Yin Glomerulocystic kidney disease Pediatr Nephrol. 2010 October; 25(10): 2049–2059.
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KIDNEY DYSPLASIA WITH PUJ STENOSIS
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ADPKD
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СИНДРОМ MECKEL–GRUBER (гломерулярно-кистозная болезнь)
fetal glomeruli and surrounding dysplastic tissue with tubular cystic changes
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Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUTIekuni Ichikawa, Fumiyo Kuwayama, John C Pope IV, F Douglas Stephens and Yoichi Miyazaki
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VUR
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PUV
Complications of PUV
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ConditionFetal ultrasonographic findings
Postnatal ultrasonographic findings
Postnatal 99mTc-DMSA renography findings
Further postnatal radiological assessment
Renal agenesis
Absent kidney (adrenal gland might be mistaken for kidney)
Absent kidneyNo renal uptake (also rules out ectopic kidney)
Investigation of contralateral kidney (see congenital solitary kidney)
Renal aplasia
Absent kidney (adrenal gland might be mistaken for kidney)
Absent kidneyNo renal uptake (also rules out ectopic kidney)
Investigation of contralateral kidney (see congenital solitary kidney)
Multicystic dysplastic kidney
Large cysts replacing kidney parenchyma and lack of central pelvis, or tiny remnant kidney (if organ involuted)
Large hypoechogenic cysts not communicating with the renal pelvis, or tiny remnant kidney (if organ involuted)
No or very little renal uptake19, 30
Investigation of contralateral kidney (see congenital solitary kidney)
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Congenital solitary kidney
Kidney might be larger than normal
Kidney should be larger than normal if healthy
No renal uptake by absent kidney (also rules out ectopic kidney)
Detection of any vesicoureteric reflux and/or ureteric obstruction
Hypoplastic kidney Small kidney Small kidney
Smooth kidney outline (pyelonephritic scarring usually produces focal defects)
Detection of any vesicoureteric reflux and/or ureteric obstruction
Cystic dysplastic kidney
Echobright kidney
Echobright kidney with cysts and poor corticomedullary differentiation
Decreased renal uptake30
Detection of any vesicoureteric reflux and/or ureteric obstruction
Autosomal recessive polycystic kidney
Large, bright kidneyEchobright, large kidney with small cysts
Focal defects (but not usually performed)31
Detection of dilated bile ducts (by hepatobiliary iminodiacetic acid isotope scan)
Autosomal dominant polycystic kidney
Large, bright kidney, sometimes with cysts
Cysts that increase in size and number with age
Generalized decreased uptake and focal defects (but not usually performed)32
Detection of any pancreatic or liver cysts or cerebral aneurysms
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RENAL AGENESIA IN NEONATE
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POLYCYSTIC KIDNEY IN NEONATES
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CYSTIC DYSPLASIACystic dysplasia
MCDK
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Novel perspectives investigating CAKUT
Renkema K Y et al. Nephrol. Dial. Transplant. 2011;26:3843-3851
© The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: [email protected]
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Vicious cycle of progressive functional and structural deterioration shared by many chronic renal diseases.
POPE J C et al. JASN 1999;10:2018-2028©1999 by American Society of Nephrology
Why sh
ould we know about C
AKUT!
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LONG LIVE KIDNEY !!!!!
Nephron 1 mln in every
kidney Length of tubules
– 18-50 мм Tubules length of
all nephrons – 100 km
80% in cortex