Molecular Function Hsa (36,91%-37,90%) Mmu (28,59%-29,56%) Dme (17,46%-18,44%)GO Entry Name Total %AS corr. p Sign Total %AS corr. p Sign Total %AS corr. p Sign

GO:0003723 RNA binding 473 41,01 1,0000 363 36,36 0,0384 *(+) 238 26,47 0,0212 *(+)GO:0004672 protein kinase activity 31 61,29 0,1478 37 45,95 0,5439 113 27,43 0,2368GO:0005509 calcium ion binding 835 41,20 0,3115 712 31,60 1,0000 89 17,98 1,0000GO:0005524 ATP binding 1328 46,31 0,0000 *(+) 1297 38,09 0,0000 *(+) 12 25,00 1,0000GO:0003676 nucleic acid binding 750 43,47 0,0085 *(+) 941 39,43 0,0000 *(+) 348 14,94 1,0000GO:0008270 zinc ion binding 1600 40,44 0,1448 1533 34,83 0,0000 *(+) 13 23,08 1,0000GO:0004674 protein ser/thr kinase activity 499 48,30 0,0000 *(+) 409 37,65 0,0026 *(+) 134 32,84 0,0007 *(+)GO:0003779 actin binding 211 44,08 0,6819 167 38,92 0,0973 118 38,98 0,0000 *(+)GO:0016887 ATPase activity 106 60,38 0,0000 *(+) 105 33,33 1,0000 32 34,38 0,5296GO:0004713 protein-tyr kinase activity 444 48,20 0,0000 *(+) 353 37,11 0,0163 *(+) 39 20,51 1,0000GO:0016740 transferase activity 929 38,00 1,0000 877 30,33 1,0000 58 15,52 1,0000GO:0016787 hydrolase activity 714 38,66 1,0000 653 26,49 1,0000 63 9,52 1,0000GO:0005515 protein binding 3218 36,73 1,0000 2061 32,07 0,0293 *(+) 133 23,31 1,0000GO:0003677 DNA binding 986 37,73 1,0000 896 31,25 1,0000 203 27,59 0,0138 *(+)GO:0003700 transcription factor activity 894 37,25 1,0000 703 26,60 1,0000 301 18,94 1,0000GO:0004871 signal transducer activity 307 43,00 0,6237 119 26,05 1,0000 24 12,50 1,0000GO:0008233 peptidase activity 152 41,45 1,0000 199 22,11 0,4102 48 8,33 1,0000GO:0003735 struct const of ribosome 270 21,85 0,0000 *(-) 506 17,79 0,0000 *(-) 157 14,01 1,0000GO:0016491 oxidoreductase activity 458 36,46 1,0000 437 20,59 0,0008 *(-) 200 8,00 0,0008 *(-)GO:0030528 transc regulator activity 99 36,36 1,0000 103 27,18 1,0000 227 16,74 1,0000GO:0005215 transporter activity 342 35,67 1,0000 300 25,67 1,0000 122 16,39 1,0000GO:0004497 monooxygenase activity 69 37,68 1,0000 67 16,42 0,3141GO:0020037 heme binding 100 35,00 1,0000 124 16,94 0,0321 *(-)GO:0004872 receptor activity 1419 28,26 0,0000 *(-) 1811 13,86 0,0000 *(-) 108 15,74 1,0000GO:0004984 olfactory receptor activity 421 0,71 0,0000 *(-) 800 0,50 0,0000 *(-) 60 0,00 0,0001 *(-)

Molecular Function Cel (9,45%-10,25%) Cne (3,42%-4,77%) Ath (8,57%-9,16%)GO Entry Name Total %AS corr. p Sign Total %AS corr. p Sign Total %AS corr. p Sign

GO:0003723 RNA binding 261 15,33 0,0811 52 7,69 1,0000 395 19,49 0,0000 *(+)GO:0004672 protein kinase activity 402 13,43 0,2936 37 5,70 1,0000 662 9,37 1,0000GO:0005509 calcium ion binding 182 16,48 0,0858 208 10,10 1,0000GO:0005524 ATP binding 832 14,66 0,0001 *(+) 1448 8,70 1,0000GO:0003676 nucleic acid binding 524 11,45 1,0000 708 13,56 0,0005 *(+)GO:0008270 zinc ion binding 841 7,49 0,2341 849 9,78 1,0000GO:0004674 protein ser/thr kinase activity 203 21,67 0,0000 *(+) 27 7,41 1,0000 707 8,06 1,0000GO:0003779 actin binding 33 27,27 0,0926 48 6,25 1,0000GO:0016887 ATPase activity 76 13,16 1,0000 62 4,84 1,0000 132 5,30 1,0000GO:0004713 protein-tyr kinase activity 101 8,91 1,0000 572 8,04 1,0000GO:0016740 transferase activity 607 11,04 1,0000 94 5,32 1,0000GO:0016787 hydrolase activity 623 9,15 1,0000 234 9,83 1,0000GO:0005515 protein binding 1408 9,09 1,0000 78 3,85 1,0000 1028 10,41 1,0000GO:0003677 DNA binding 916 7,75 0,3705 37 2,70 1,0000 1287 10,10 1,0000GO:0003700 transcription factor activity 467 9,64 1,0000 41 0,00 1,0000 1666 10,80 0,0765GO:0004871 signal transducer activity 170 15,29 0,3939 37 2,70 1,0000 99 6,06 1,0000GO:0008233 peptidase activity 184 8,15 1,0000 9 0,00 1,0000 106 10,38 1,0000GO:0003735 struct const of ribosome 135 13,33 1,0000 121 0,00 0,1445 350 10,29 1,0000GO:0016491 oxidoreductase activity 408 6,62 0,3318 19 0,00 1,0000 352 11,65 1,0000GO:0030528 transc regulator activity 48 10,42 1,0000 101 7,92 1,0000GO:0005215 transporter activity 210 6,67 1,0000 47 4,26 1,0000 300 9,00 1,0000GO:0004497 monooxygenase activity 92 0,00 0,0018 *(-) 259 3,47 0,0131 *(-)GO:0020037 heme binding 126 0,79 0,0008 *(-) 218 3,21 0,0201 *(-)GO:0004872 receptor activity 1032 6,01 0,0001 *(-) 6 0,00 1,0000 31 0,00 1,0000GO:0004984 olfactory receptor activity