Download - 10229 ABS White Willow Bark Extract Powder
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10229 ABS White Willow Bark Extract PowderEnhances Cell Renewal + Antioxidant + Antimicrobial
Product Code: 10229
INCI Name: Salix alba (White Willow) Bark Extract
INCI Status: Approved
Suggested Use Levels: 1.0 – 10.0%
Suggested Applications: Exfoliation, Great for Problem Skin, Antioxidant
Solubility: Water Soluble
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• Traditionally used as a remedy for its anti-inflammatory and analgesic properties, willow bark extracts are employed as a source of natural salicylates.
• Salicylic acid has been identified as part of the willow tree’s endogenous defense mechanisms – protects against invading pathogens
• The bark of the white willow is a natural source of salicylic acid-like ingredients
• ABS White Willow Bark Extract Powder is standardized for 53-65% natural salicylates and provides formulators with the perfect alternative to synthetic salicylic acid products!
10229 ABS White Willow Bark Extract PowderNatural Alternative to Salicylic Acid
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• ABS White Willow Bark Extract Powder is ideal for reducing inflammation and associated redness, plus, it acts as an efficacious antimicrobial.
• As reported at the Society of Investigative Dermatology, White Willow Bark Extracts provide the benefits of salicylic acid without any of the typically associated irritation usually found when using synthetic AHAs
• Water-solubility of ABS White Willow Bark Extract Powder promotes seamless incorporation into a variety of formulas promoting all of the benefits associated with salicylic acid and none of the irritation!
10229 ABS White Willow Bark Extract PowderEfficacy Without Irritation
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10229 ABS White Willow Bark Extract PowderAvailable Efficacy
• In-vivo Efficacy Studies• Cellular Renewal Assay• High Resolution Ultrasound Skin Imaging Assay• Salon Half Head Study
• In-vitro Efficacy Studies• Challenge Test• Inhibition Activity vs. P. acnes and S. aureus• Oxygen Radical Absorbance Capacity Assay• IL-6 ELISA
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10229 ABS White Willow Bark Extract Powderin-vivo Cellular Renewal Assay
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• 15 m/f volunteers
• Control: 5.0% Petroletum-Based DansylChloride Solution
• Test materials: 1.0% Synthetic Salicylic Acid (3.9 pH w/w) + 2.0% ABS White Willow Bark Extract Powder (equivalent to 1.0% Synthetic SA)
• UV light was used to determine the color intensity relative to the level of binding and percent increase in cellular renewal
• ABS White Willow Bark Extract Powder is capable of increasing cellular renewal
Figure 1. Increase in cellular renewal.
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10229 ABS White Willow Bark Extract Powderin-vivo High Resolution Skin Imaging
Protocol
• Equipment: DermaLab Combo
• Principle of measurement: Conductance, single frequency
• Subjects: 10 (m/f)
• Test area: Volar forearms
• Concentration of active used: 2.0%
• Frequency of application: Twice Daily
• ABS White Willow Bark Extract Powder is capable of significantly improving skin density
Figure 2. Improvements in skin density following application of the test materials.
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10229 ABS White Willow Bark Extract Powderin-vitro Antimicrobial Assay – Zone of Inhibition
Protocol
• The zone of inhibition for 2.00% ABS White Willow Bark Extract Powder was determined in relation to the zones of inhibition for 1.00% Salicylic acid and Butylene glycol against both S. aureus and P. acnes.
• 2.00% ABS White Willow Bark Extract Powder is more effective than 1.00% Salicylic Acid in inhibiting the growth of both S. aureus and P. acnes.
Figure 3. Zone of inhibition data for S. aureus.
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10229 ABS White Willow Bark Extract Powderin-vitro Antimicrobial Assay – Zone of Inhibition
Protocol
• The zone of inhibition for 2.00% ABS White Willow Bark Extract Powder was determined in relation to the zones of inhibition for 1.00% Salicylic acid and Butylene glycol against both S. aureus and P. acnes.
• 2.00% ABS White Willow Bark Extract Powder is more effective than 1.00% Salicylic Acid in inhibiting the growth of both S. aureus and P. acnes.
Figure 4. Zone of inhibition data for P. acnes
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10229 ABS White Willow Bark Extract PowderOxygen Radical Absorbance Capacity (ORAC) Assay
Protocol
• Trolox® was used as the positive control
• Test Quantity: 0.001% and 0.0005%
• Fluorescent measurements were taken every two minutes for two hours
• ABS White Willow Bark Extract Powder showed antioxidant activity at levels as low as 0.0005%
Figure 5. Antioxidant activity of test materials
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10229 ABS White Willow Bark Extract Powderin-vitro IL-6 ELISA Assay
Protocol
• Human dermal fibroblasts were seeded into 12-well tissue culture plates
• Test materials were added to complete DMEM containing 1µg/mL LPS and incubated with fibroblasts for 24 hours
• Concentrations: 1%, 0.1%, 0.01%
• ABS White Willow Bark Extract Powder exhibited anti-inflammatory effects on LPS-treated fibroblasts
• The changes in IL-6 production using ABS White Willow Bark Extract Powder appear to be dose dependent
Figure 6. Reduction in IL-6 concentration
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10229 ABS White Willow Bark Extract PowderEnhances Cell Renewal + Antioxidant + Antimicrobial
Product Code: 10229
INCI Name: Salix alba (White Willow) Bark Extract
INCI Status: Approved
Suggested Use Levels: 1.0 – 10.0%
Suggested Applications: Exfoliation, Great for Problem Skin, Antioxidant
Solubility: Water Soluble