Download - 04 nerve singnal processing
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Giant Nerve Cells of Squid
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Ion distribution across cell membrane
A. Effect of concentration difference
B. Electrical potential difference affecting negative ions
C. Pressure difference
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Transport of solutes across the Neuronal membrane
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Ion movement across cell
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Resting membrane Potential
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Action Potential
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Propagation of AP
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Saltatory conduction
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The Refractory Period
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Synapse
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Electrical synapse
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Chemical Synapse
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Chemical Synapse at Neuromuscular Junction
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Neurotransmitter release
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Post synaptic receptor
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Excitatory and Inhibitory Post Synaptic Potential
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Excitatory and Inhibitory signals
Excitatory and inhibitory currents have competitive effects in a single nerve cell. (Adapted from Eckert et al., 1988.)
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Inhibition
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Neurotransmitters
1. The substance must be present within the presynaptic neuron
2. The substance must be released in response to presynaptic depolarization, and the release must be Ca2+-dependent.
3. Specific receptors for the substance must be present on the postsynaptic cell
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Major classes of NT
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Acetyl Choline
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Cholinergic Receptors in Normal Brain
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Serotonin System
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Dopamine System
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Norepinephric System
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Glutamate System
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GABA System
•Widespread in the brain and spinal cord•Inhibitory by increasing permeability to Cl
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Second Messenger