Download - 第八章 芳香胺类 药物的分析
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Analysis of Aromatic amines
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benzocaine, procaine hydrochlorideparacetamol, lidocaine hydrochlorideadrenaline, dopamine hydrochlorideoxprenolol, carteolol hydrochloride
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Contents
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(Feature)2. BABAPABA3. 4. 1. Schiff
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1. 3. 4. 5. (Feature)2.()+/
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--Identification
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1.2.Identification
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Identification
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/ /Identification
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a. b.Identification
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10NaOH()Identification
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UVIdentification
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Identification
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IR cm-1 cm-1 C=O 1692 C-O 1271, 1170, 1115 N-H 2585 2645 1550 N-H 1280 N-H Identification
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Identification
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Detection of specific impurities11 2pH5.5-6.5(1
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Detection of specific impurities2.3.O-TLC(254nm)
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Detection of specific impurities4. 1.0g1220ml1ml30min1.0g50g0.005%
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Detection of specific impurities1.2%TLC
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Detection of specific impurities (ropivacaine) SR
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Detection of specific impurities
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Assay (volumetric analysis) ( spectrometry ) ( chrometography ) (sodium nitrite method)(non-aqueous titrimetry)
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Assay(sodium nitrite method)NaNO2 + HCl HNO2 + NaClHNO2 + HCl NOCl + H2OHBrNO+ HBrNO+
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Assay11030HNO2 [Ar-NN]Cl- + H2O Ar-OH + N2+ HCl2 3NaNO2,42/3HNO25KBr6(-)
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Assay(non-aqueous titrimetry)
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AssayUV257nm2005
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AssayHPLCHPCE
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(Phenethylamine)
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*
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Identification
Adrenaline0.1mol/LNoradrenaline bitartratePhenylephrine hydrochlorideIsoprenaline hydrochloride5%Dopamine hydrochloride1%
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Identification
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IdentificationUVIR
(mg/ml)nm (nm) (A)0.102720.052800.500.5%0.032800.1mol/L0.25263, 2700.012340.600.1mol/L0.03243, 2960.082740.50251, 257, 263
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IdentificationChp 10mg1ml220%1ml1ml
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Detection of specific impurities
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Detection of specific impurities
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Detection of specific impurities
C(mg/ml)(nm) A HCl(92000) 2.0 3100.05 2.0 3100.20 2.0 3100.05 2.0 3100.15 1.5 3470.06
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Detection of specific impuritiesHPLCTLC
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Assay
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Assay()
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Assay2
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Assay()8ml 0.05mol/L25ml20.1mol/L1ml0.05mol/L18.42mgC18H26N2H2SO4
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AssayUV HPLC (GC-MS)
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(enalapril maleate)(benazepril hydrochloride)(lisinopril)
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(lisinopril)
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Identification
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Detection of specific impurities
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Assay(Ch.P)(BP)-HPLC
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Assay