dosimetry for medical application of ionizing radiations: calibration requirements and clinical...

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DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac , Milojko Kovacevic, Danijela Arandjic, Djordje Lazarevic Vinca Institute of Nuclear Sciences Radiation and Environmental Protection Department Laboratory for Radiation Measurements Belgrade, Serbia [email protected] Vinca Institute of Nuclear Sciences Radiation and Environmental Protection Laboratory www.vinca.rs

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Page 1: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS:

Calibration requirements and clinical applications

Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela Arandjic, Djordje LazarevicVinca Institute of Nuclear SciencesRadiation and Environmental Protection DepartmentLaboratory for Radiation MeasurementsBelgrade, [email protected]

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Page 2: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Content

Global trends in medical exposures Dosimetric quantities and units Dosimetry in diagnostic radiology

Metrology and calibration requirements Clinical application

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Page 3: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Medical exposure contributes 99% of man-made radiation exposure to humans

The concept of risk is used to quantify possible detrimental effects

Medical exposure to ionizing radiation

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0.61

0.0020.005

0.0020.005

mSv

Medical

Nuclear weapons

Occupational

Chernobyl

Atmospheric nuclear tests

Total dose from man-made sources of radiation> 0.61 mSv

Medical: 0.6 mSv (> 99.97%)

Source: United Nations Scientific Committee for Effect of Atomic Radiation (UNSCEAR), 2010

Page 4: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Dose?

Medical exposure to ionizing radiation

The role of dosimetry is to determine the amount of radiation received by a person from the radiological examination

Page 5: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Dosimetry in diagnostic radiology

Patient dose assessment Establishment of Diagnostic Reference Levels

(DRL), optimisation of protection Assessment of x-ray equipment performance

Standards of good practice Assessment of radiation detriment

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Page 6: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Global trend

3,6 billion radiological examinations in the period 1997-2007

Increase of 50% compared to previous decade Significant increase of CT practice:

Examination frequency Dose per examination

Interventional procedures

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Page 7: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Depends on the examination type Variations for the same type of procedure

0.02- 0.05 mSv@2 mSv @ 100CxR

5-20 mSv400- 1000 CxR

Dose to patient

50 chest radiographies= annual natural background radiation dose

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Page 8: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Problems

Dose for the same examination type varies up to 2 orders of magnitude

Increased utilization of high-dose procedures

CT

Interventional procedures

Increase of probability for stochastic effects, in particular in the case of the repeated examinations

Possible radiation injuries in high-dose procedures

Effects

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Page 10: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Radiation injuries

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ICRP 85

Page 11: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Basic metrology elements

International Measurements System (IMS)

Framework for dosimetry in diagnostic radiology

Consistency in radiation dosimetry

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Page 12: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

International Measurements System (IMS)

Bureau International des Poids et Mesures (BIPM)

National Primary Standard Dosimetry Laboratories (PSDL)

Secondary Standards Dosimetry Laboratories (SSDL)

Users performing measurements

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Traceability chain

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Page 14: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Metrology and traceability

Dosimeters used to determine doses received by individuals

Measurements need to be traceable though an unbroken chain of comparisons to national and international standards

Traceability is needed to ensure accuracy and reliability

Legal and economic implications

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Role of the SSDL

The prime function: to provide a service in metrology

Designated by the competent national authorities

SSDL-Secondary standards, calibrated against the primary standards of laboratories participating in the IMS

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Page 16: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Journal of the ICRU Vol 5No 2 (2005) Report 74

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Dosimetric quantities in units in diagnostic radiology Basic dosimetric quantity: Air kerma

Easy to measure Calibration:

Dosimeters calibrated in terms of air kerma Clinical application:

Quantities derived from air kerma for different imaging modalities

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Dosimetric quantities

Basic dosimetric quantities Application specific dosimetric quantities

Quantities for risk assessment

Conversion coefficient for tissue and organ dose assessment

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Energy fluenceUnit:J/m2

KermaUnit:J/kg, Gy

Absorbed doseUnit:J/kg, Gy

dadR

trtr

dmdE

K

en

dmd

D

Basic dosimetric quantities

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Basic dosimetric quantities

Charged-particle equilibrium Absence of bremsstrahlung losses

trenDK

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Application specific dosimetric quantities

Quantity Symbol Unit Equation

Incident air kerma Ki Gy

Entrance -surface air kerma Ke Gy

Air-kerma area product PKA Gym2

Air-kerma length product PKL Gym

X-ray tube output Y(d) Gy/As

BKK ie

A

KA dxdyyxKP ),(

L

airKL dzzKP )(

Ita PdKdY /)()(

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Application specific dosimetric quantities: computed tomography

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Quantity Symbol Unit Equation

CT air-kerma index (free in air) Ca,100 Gy

CT air-kerma index (in standard phantom)

CPMMA, 100 Gy

Weighted CT air kerma index Cw Gy

Normalized weighted CT air kerma index nCw Gy/As

Air-kerma length product PKL Gym

Application specific dosimetric quantities: computed tomography

pPMMAcPMMAW CCC ,100,,100, 231

50

50100, )(

1dzzK

TCa

It

VOLVOLn

WWVOL

PC

C

pC

INT

CC

j

ItjjVOLjnKL PlCP

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Quantities describing risk

Organ and tissue dose Equivalent dose Effective dose

Dose-conversion coefficients for assessment of organ and tissue doses

quantityionnormalisat

quantitydosimetricc

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The Use of Effective Dose (E)

E is a risk-related quantity and should only be used in the low-dose range

Primary use: to demonstrate compliance with dose limits in regulation, for prospective planning of radioprotection

Not for: detailed retrospective dose and risk assessments after exposure

of individuals epidemiological studies, neither in accidents.

In the last cases: organ doses are needed !

ICRP 103, ICRP 105

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Effective Dose in Medical Exposure

The relevant quantity for planning the exposure of patients and risk-benefit assessments is the equivalent dose or the absorbed dose to irradiated tissues.

The assessment and interpretation of E is very problematic when organs and tissues receive only partial exposure or a very heterogeneous exposure (x-ray diagnostics)

E can be of value for comparing doses from different diagnostic procedures similar procedures in different hospitals and countries different technologies for the same medical examination.

ICRP 103, ICRP 105

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Dosimeters in diagnostic radiology

Tube voltage 20-150 keV, various A/F combinations, various modalities

Ionization chambers

Accurate

Good energy dependence

Design for different application (cylindrical, parallel-plate, different volumes..)

Semiconductor dosimeters

Compact

Energy dependant

Others

TLD

OSL

Film (radiochromic)

Scintillation

(kVp meters)

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PSDL/SSDL user

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Dosimetry standards in diagnostic radiology IEC 61674: Dosimeters with

ionization chambers and/or semi-conductor detectors as used in X-ray diagnostic imaging Diagnostic dosimeter:

detector and measuring assembly

IEC 60580: Dose area product meters

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Requirements for dosemeters

User IEC 61674 Ionization chambers Semiconductor

detectors

SSDL Ionization chamber of

reference class

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Calibrations in diagnostic radiology

Air kerma: Radiography and mammography

Kerma-length product Dosimeters in CT

Kerma-area product Radiography and fluoroscopy

PPV: kVp meters

Frequency: according to national regulations V

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Calibration in diagnostic radiology

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SSDL with relevant measurement capabilities General requirements: beam qualities, tube

voltage and filtration measurements Dosimeter of reference class (with

electrometer) Calibrated Quality control Traceability for all beam qualities

Auxiliary equipment: electrometers, thermometers, barometers…

Environmental conditions

Page 33: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Equipment

Dosimetry Ionization chambers Position system HV supply for monitor and

reference class ionization chamber

Electrometer

Radiation source X-ray generator, 50-150

kVp, 20-40 kVp Ripple less than 10% for

radiography and less than 4% for mammography

Beam qualities according IEC 61267

“Shutter” mechanism Filters and attenuators Tube voltage meter (ppv,

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Application Type of chamber

Range tube voltage (kV)

Intrinsic uncertainty

(k=2)Maximum variation

of response (%)

Range of air kerma rate

Unatte-nuated beam

Attenuated beam

General radiography

cylindrical or plane parallel 60-150 3.2 ±2.6 1 mGy/s-

500 mGy/s10 μGy/s-5 mGy/s

Fluoroscopy cylindrical or plane parallel 50-100 3.2 ±2.6 0.1 μGy/s-

100 μGy/s

Mammogra-phy plane parallel 22-40 3.2 ±2.6 10 μGy/s-

10 mGy/s

CT cylindrical 100-150 3.2 ±2.6 0.1 mGy/s-50 mGy/s

Dental radiography

cylindrical or plane parallel 50-90 3.2 ±2.6 1 μGy/s-

10 mGy/s

Reference class dosemeter

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Specification of the x-ray beam

Spectrum X-ray beam quality:

First half-value layer (HVL1) Second half-value layer

(HVL2) Homogeneity coefficient:

Tube voltage Total filtration

2

1

HVL

HVLh

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Radiation beam qualities (IEC 61267)

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Radiation quality Radiation origin Phantom material Application

RQRUnfiltered beam emerging from x-ray assembly

No phantomGeneral radiography, fluoroscopy, dental radiology

RQA Radiation beam from an added filter Aluminium

Measurements behind the patient (on the image intensifier)

RQT Radiation beam from an added filter Copper CT applications (free

in air)

RQR-MUnfiltered beam emerging from x-ray assembly

No phantom Mammography (free in air)

RQA-M Radiation beam from an added filter Aluminium Measurements

behind the patient

Page 37: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Typical calibration set up

X-ray tube window

Focal spot

Shutter

Apertures

Additional filtration

Monitor chamber

Test point

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Calibration procedures

Procedures before calibration (acclimatization, positioning, stabilization…)

Calibration procedures (methods, number of measurements, interval between measurements…corrections…

Procedures following calibration (uncertainty budget, certificate…)

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Dosimetry formalism

Air kerma:

Reference conditions: set of influencing quantities

Influencing condition: quantities that are not subject of mesusremst but have an impact on the result

Air density correction: Beam quality correction:

0,0 QKQ NMMK

i

iQKQ kNMMK0,0

0

0

15.273

15.273

T

T

P

PkTP

QoQQKQQ kNMK ,, 0

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Calibrations of dosemeters for CT

Traditionally, irradiation of the whole volume Contras:

Information on chamber response only Size on active volume only assumed Far from real situation

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Calibration for CT: air kerma length product Cylindrical chamber, 100 mm Non-uniform irradiation Uniform response RQT 9 (120 kVp, HVL: 8.5 mm Al)

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Focal spot

Monitor chamber

Aperture Ionization chamber

w

da

dr

a

rQP d

dMwKN

KL /,

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In laboratory (SSDL) Field calibration

Film

10 cm 10 cm

Ref. chamber

KAP

nomQrefQoK

ref

QP M

AkNMN

KA

,,

Calibration for fluoroscopy: air kerma area product

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Cekerevac at al, Poster B3

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Calibration in terms of practical peak voltage X-ray tube voltage

measurements Practical Peak Voltage

(ppv):

Property of the whole exposure cycle

Related to image contrast

Invasive or non-invasive measurements

Voltage divider

n

iii

n

iiii

UwUp

WwUUpU

1

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Uncertainty of the reference standard Uncertainty of user’s instrument Uncertainty due to calibration set up Uncertainty of the evaluation procedure

Uncertainty budget

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Uncertainty budget

Air kerma: ± 2.7 % Air kerma length product: ± 3.0 % Air kerma area product: ± 15 % Non-invasive tube voltage measuring devices:

2.5 %

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Goal: minimal uncertainty Assurance and control of traceability Quality manual: technical details, methods, traceability,

uncertainty budget, QC, safety…. Continuous improvements and reviews External peer review/audit

Quality Management System

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Patient dose assessment

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Clinical dosimetry

Direct measurement on patients or phantoms

Indirect measurements on patients or phantoms Output of the X-ray tube,

scaled for exposure and geometry

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Dosimetric quantites

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BSFKAP

Ke

Quantitiesa) incident air kerma, entrance

surface air kerma and kerma-area product (radiography);

b) kerma-area product and entrance surface air kerma rate (fluoroscopy);

c) incident and entrance surface air kerma (mammography); and

d) kerma-length product (computed tomography)

Page 50: DOSIMETRY FOR MEDICAL APPLICATION OF IONIZING RADIATIONS: Calibration requirements and clinical applications Olivera Ciraj-Bjelac, Milojko Kovacevic, Danijela

Patients and phantoms

Patient Real situation

Phantoms Objects that simulate real

patients in terms of interaction of radiation with matter

Easy to perform Standardized

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Radiography

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Fluoroscopy

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Mammography

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Computed tomography

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Patient dose levels

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Uncertainty of clinical dose assessment Radiographers taking the

x-ray images Determining tube output Calculation of individual

patient doses Determining dose to an

average patient

Use of k=2 for expression of uncertainty of dose assessment

Typically >10% and close to 25%*

*if correction for beam quality and for individual patient is not applied

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Form measurements towards risk assessment Conversion coefficients

Conversion of measured quantity into organ doses and effective dose

Ratio of the dose to a specified tissue or effective dose divided by the normalization quantity

Measured using phantoms or calculated using computer models

Voxel phantoms based on images of human anatomy

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Organ dose assesment

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ICRU 74

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Optimization of protection

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Application of DRLs

Values of measured quantities above which some specified action or decision should be taken Values must be specified Action must be specified

DRLs will be intended for use as a convenient test for

identifying situations where the levels of patient dose are unusually high.

Quantities that are easily measured!

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Diagnostic Reference Levels

Doses to patients from radiographic and fluoroscopic X-ray imaging procedures in the UK—2005 review. HPA RPD-029, HPA; 2007. V

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Re-cap

Diagnostic radiology is major contribution to total dose from man-made sources of radiation

Dose measurements: population dose assessment, optimization of practice

Application-specific dosimetric quantities (patients, phantoms)

Calibration of dosimeters in the conditions that are similar to the clinical environment, in terms of air kerma kerma-area product kerma-length product V

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Olivera Ciraj-Bjelac, PhD, research associate, dosimetry and radiation physics Milojko Kovacevic, MSc, Head of MDL, radiation physicist Danijela Arandjic, MSc, PhD student, dosimetry and radiation physics Djordje Lazarevic, MSc, PhD student, dosimetry and radiation physics Dragana Divnic, technician Milos Jovanovic, technician Nikola Blagojevic , technician

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