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There were 118 cases of LABC

referred to our Institute during the

study period.

We found a statistical significant

relationship between young age group

( ≤40) and hormonal treatment

(p=0.03).

Also, there was a statistical

significant relationship between triple

negative cases and local recurrence (

p= 0.001).

Our patients' age ranged from 25 to

75 years with median = 50.5 years.

Eighty-eight ( 75.9%) cases received

neoadjuvant chemotherapy. Seventy-

four ( 66.1%) cases received adjuvant

treatment. Fourty –two ( 38.2%) cases

had > 3 positive lymph nodes. Eighty-

one ( 71.7%) cases underwent MRM.

Only, 5 ( 4.3 %) cases were of ILC

pathological type.

T3 was identified in 53 ( 44.5%)

cases. Grade 2 of differentiation was

proved in 113 ( 95%) cases.

Ninety –two ( 77.3%) cases were ER

positive. Eighty-one ( 68.1%) cases

were PR positive. Eighty-eight

(73.9%) cases were HER2/neu

positive.

Seventy- nine ( 66.4%) cases

received adjuvant radiotherapy.

•Women with locally advanced

breast cancer (LABC) who are

breast conservation (BCT)

candidates after neoadjuvant

chemotherapy have the best long-

term outcome and low local–

regional recurrence (LRR) rates.

• However, young women are

thought to have a higher risk of

LRR based on historical data.

• Our aim is to identify the clinico-

pathologic characteristics affecting

locally advanced breast cancer

patients referred to National Cancer

Institute, Cairo University, Egypt.

BACKGROUND AND STUDY DESIGN

CONCLUSIONS

Does Locally Advanced Breast Cancer Differ in Egyptian Patients? Fatma M.A. Abou El-kasem MD 1 , Marwa Nabil Abdel-Hafez MD 1, Heba Gamal El-din MD 2, Amira Ismail Abdul-Rahman 3

. 1-Medical Oncology Department , National Cancer Institute, Cairo University, Egypt.

2-Surgical Oncology Department , National Cancer Institute, Cairo University, Egypt.

3-Biostatistics and Cancer Epidemiology, National Cancer Institute, Cairo University, Egypt.

Logo

Here

Retrospective review of patients

with locally advanced breast cancer

(LABC) presented to National

Cancer Institute, Cairo University,

Egypt; over 4 years of the study

period.

Detailed clinical, surgical and

pathological data were obtained

from all patients.

Pearson's chi(2) and Fisher's

Exact tests were used for

statistical analysis.

MATERIAL & METHODS •There is a statistical significant

correlation between young age group

( ≤40) and hormonal treatment (p=

0.03).

•Also, a statistical significant

relationship between triple negative

cases and local recurrence ( p= 0.000)

is identified.

•Addition of hormonal treatment to

neoadjuvant chemotherapy is

recommended for young ER or PR

positive breast cancer patients.

•Adjuvant radiotherapy for triple

negative breast cancer patients is

recommended to avoid local

recurrence.

RESULTS

Age Range [median] 25-75 [50.5]

Type IDC

ILC

Mixed IDC&ILC

106/118

5/118

4/118

Operative Procedure

MRM

CBS

81/118

18/118

Lymph node:

>3 positive nodes

42/118

Size:

T3

53/118

Grade

II

113/118

Laterality

RT.

LT

Bilateral

69/118

47/118

2/118

Treatment

Neoadjuvant Therapy

Adjuvant nolvadex

Adjuvant CTH

Adjuvant RTH

88/118

67/118

74/118

79/118

Clinical and pathologic features

Distant Metastasis

22

Bone Metastasis

8

Local Recurrence

11

Tumor Progression