EDITORIALS1093 Can Primary Care Medicine Be Saved?

Joseph S. Alpert

1095 The D-batable Parathyroid Hormone PlateauMichael F. Holick

COMMENTARY1097 Calcium Supplements and Risk of Myocardial

Infarction: A Hypothesis Formulated ButNot Yet Adequately TestedCharles H. Hennekens and E. Joan Barice

REVIEWS1099 Management of the Metabolic/Bariatric

Surgery PatientHenry Buchwald, Sayeed Ikramuddin,Robert B. Dorman, Joyce L. Schone, and John B. Dixon

As the obesity epidemic in the US spreads, manage-ment of obese patients and those who have had bari-atric surgery will become more common. This thor-ough review discusses the comorbidities of obesity,preoperative selection of bariatric surgery candidates,postoperative care, and other management issues.

1106 Care of the Adult Hodgkin Lymphoma SurvivorCarrie A. Thompson, Karen Mauck,Rachel Havyer, Anjali Bhagra, Henna Kalsi, andSharonne N. Hayes

Eighty-five percent of Hodgkin lymphoma patientswill survive. That’s the good news. The bad news isthat many will live with residual effects of theircancer and its treatment. This review providesmuch-needed background information for internistswho provide care for Hodgkin lymphoma survivors.

1113 Cellulitis: Definition, Etiology, and ClinicalFeaturesCraig G. Gunderson

Cellulitis is a skin condition commonly seen byphysicians. As skin infections caused by methicil-lin-resistant Staphylococcus aureus (MRSA) havebecome more prevalent, it is important for physi-cians to differentiate between cellulitis and necro-tizing soft tissue infections.

UPDATE IN OFFICE MANAGEMENT1123 Sleep Disordered Breathing in the Elderly

Tonya Russell and Stephen Duntley

CLINICAL EFFECTIVENESS1127 Contrast-induced Nephropathy Risk

Assessment in Real World PracticeAmir B. Rabbani and Brahmajee K. Nallamothu

DIAGNOSTIC DILEMMA1129 Steroid-responsive but not Rheumatologic

Clare Kelleher and Carrie Herzke

IMAGES IN DERMATOLOGY1132 A Blast from the Past

Leann Silhan and Robert M. Reed

THE AMERICAN

JOURNAL ofMEDICINE ®

www.amjmed.comCONTENTS

The Green Journal December 2011 Volume 124/Number 12

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CLINICAL RESEARCH STUDIES1136 Anticoagulation-associated Adverse Drug Events

Gregory Piazza, Thanh Nha Nguyen,Deborah Cios, Matthew Labreche,Benjamin Hohlfelder, John Fanikos,Karen Fiumara, and Samuel Z. Goldhaber

Most anticoagulant-associated adverse drug events(70%) are potentially preventable. Transcriptionerrors comprise the most frequent root cause ofanticoagulant-associated medication errors. Inturn, medication errors often lead to anticoagu-lant-associated adverse drug reactions.

1143 Venous Thromboembolism Prophylaxis forMedical Service—Mostly Cancer—Patients atHospital DischargeJohn Fanikos, Amanda Rao, Andrew C. Seger,Gregory Piazza, Elaine Catapane, Xiaohua Chen,and Samuel Z. Goldhaber

Extended pharmacologic thromboprophylaxis inhigh risk medical service patients did not reducesymptomatic deep vein thrombosis and pulmonaryembolism in the ensuing 90 days after hospitaldischarge. Furthermore, there was a higher inci-dence of all-cause death and major bleeding epi-sodes in patients receiving extended prophylaxis.

1151 Patients with Acute Coronary Syndrome andNormal High-sensitivity TroponinChristophe Meune, Cathrin Balmelli,Raphael Twerenbold, Tobias Reichlin, Miriam Reiter,Philip Haaf, Stephan Steuer, Stefano Bassetti,Konstantin Sakarikos, Isabel Campodarve,Christa Zellweger, Affan Irfan, Beatrice Drexler, andChristian Mueller

Almost one-third of patients with acute coronary syn-drome—particularly those with unstable angina—havenormal high-sensitivity cardiac troponin T levels atpresentation. Although these patients have a very lowmortality, they have an increased rate of acute myo-cardial infarction during the subsequent 360 days.

1158 Pyogenic Liver Abscess as the Initial Manifestationof Underlying Hepatocellular CarcinomaYi-Tsung Lin, Chia-Jen Liu, Tzeng-Ji Chen,Te-Li Chen, Yi-Chen Yeh, Hau-Shin Wu,Chih-Peng Tseng, Fu-Der Wang,Cheng-Hwai Tzeng, and Chang-Phone Fung

The prognosis of patients who present with pyogenicliver abscess as the initial manifestation of underlyinghepatocellular carcinoma is poor. In regions with ahigh prevalence of both pyogenic liver abscess andhepatocellular carcinoma, physicians should not ig-nore the possibility of underlying hepatocellular carci-noma in patients with risk factors.

1165 The Relationship Between Serum 25(OH)D andParathyroid Hormone LevelsWalid Saliba, Ofra Barnett, Hedy S. Rennert,Idit Lavi, and Gad Rennert

Low 25(OH)D levels are associated with increasedparathyroid hormone levels leading to progressivebone loss. The data from this study suggest that a25(OH)D threshold of 50 nmol/L is sufficient for para-thyroid hormone suppression and prevention of sec-ondary hyperparathyroidism in persons with normalrenal function.

1171 Endothelial Dysfunction Is Reversible inHelicobacter Pylori-Positive SubjectsArnon Blum, Snait Tamir, Keren Mualem,Rotem Shelly Ben-Shushan, Lital Keinan-Boker,and Maya Paritsky

Helicobacter Pylori infection—usually subclinical—may cause endothelial dysfunction and atherosclerosiswith future cardiovascular events. H Pylori eradicationwith antibiotics can change the clinical outcome, im-prove endothelial dysfunction and may prevent futureatherosclerosis and cardiovascular events.

AJM ONLINE

Please note that articles with an “e” pagedesignation are available only in the onlineversion of the Journal at www.amjmed.com.

CLINICAL RESEARCH STUDIES1175.e1 Study of Nonoutbreak Giardiasis: Novel

Findings and Implications for ResearchPaul T. Cantey, Sharon Roy, Brian Lee,Alicia Cronquist, Kirk Smith, Jennifer Liang,and Michael J. Beach

Up to 20% of persons with laboratory-confirmedGiardia infection had not received appropriate treat-ment. Intermittent diarrhea, which was reported by asignificant number of patients with symptoms, mayhave contributed to a delay in diagnosis. Diarrheamay be an important clue in the diagnosis of Giardiainfection.

1175.e9 Processes of Care and Outcomes forCommunity-Acquired PneumoniaJonathan S. Lee, Brian A. Primack, Maria K. Mor,Roslyn A. Stone, D. Scott Obrosky,Donald M. Yealy, and Michael J. Fine

Although processes of care are common proxies forhealth care quality, neither the individual processesof care nor the cumulative number performed areassociated with short-term mortality for pneumonia.

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CLINICAL COMMUNICATIONS TO THE EDITORe1 Reversible Nutritional Hypogonadism in a

22-Year-Old ManAviva Shemesh, Ronit Endevelt, and Yishai Levy

e3 How Late Is Too Late? Giant Balloon-likeAneurysm of the Ascending AortaSiegrun Mebus, Christian Meierhofer,Milka Pringsheim, Patric Schoen,Harald Kaemmerer, John Hess, Katrina Oberberg,and Norbert Mayr

e5 The Third DimensionChristopher Sankey and Paras Bhatt

e7 Hypothyroid Cardiomyopathy: A ReversibleForm of Systolic Heart FailureAjay J. Kirtane and Warren J. Manning

LETTERSe9 The Perils of PowerPoint

Edward J. Volpintesta

e11 B-type Natriuretic Peptide and Chest Pain:Do Not Forget Left Ventricle FunctionColin J. Petrie and Ross T. Campbell

e13 The ReplyPhilip Haaf, Tobias Reichlin, andChristian Mueller

e15 Importance of Troponin Levels in the EarlyDetection of Anthracycline-associatedCardiomyopathyJames J. Glazier

e17 The ReplyVincent M. Figueredo

BRIEF OBSERVATION1176 Brachial Artery Flow-mediated Dilation in

Patients with Tako-Tsubo CardiomyopathyElena Vasilieva, Inna Vorobyeva, Anna Lebedeva,Irina Urazovskaya, Anna Kalinskaya,Dmitriy Skrypnik, and Alexander Shpektor

APM PERSPECTIVES1180 Success in Grateful Patient Philanthropy:

Insights from Experienced PhysiciansRosalyn Stewart, Leah Wolfe, John Flynn,Joseph Carrese, and Scott M. Wright

MEDICAL HUMANITIES PERSPECTIVES1186 Renal Calculosis of Pandolfo III Malatesta

(1370-1427)Valentina Giuffra, Luca Ventura,Simona Minozzi, Agata Lunardini,Raimondo Quaresima, Lorenzo Arrizza, andGino Fornaciari

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