4.65

•PMS BLACKCVC •CYAN •MAGENTA •YELLOW •BLACK

REGULAR ARTICLES

Intracellular free calcium concentration and calcium transport in human erythrocytes of lead-exposed

workers

M.A. Quintanar-Escorza, M.T. Gonzalez-Martınez, L. Navarro, M. Maldonado, B. Arevalo,

J.V. Calderon-Salinas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure of normal human dermal fibroblasts results in

AhR-dependent and -independent changes in gene expression

A.M. Akintobi, C.M. Villano, L.A. White . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and

ERK1/2 in human embryo lung fibroblast cells

Xiao-Qing He, Rui Chen, Ping Yang, Ai-Ping Li, Jian-Wei Zhou, Qi-Zhan Liu. . . . . . . . . . . . . . . . . . . . 18

Characterization of Bizzy Nut extracts in estrogen-responsive MCF-7 breast cancer cells

Krystal Fontenot, Srivatcha Naragoni, Michelle Claville, Wesley Gray . . . . . . . . . . . . . . . . . . . . . . . . . . 25

Online monitoring of cell metabolism for studying pharmacodynamic effects

Elke Thedinga, Axel Kob, Heiko Holst, Andreas Keuer, Sabine Drechsler, Ricarda Niendorf,

Werner Baumann, Ingo Freund, Mirko Lehmann, Ralf Ehret . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33

Gene expression profiles of murine fatty liver induced by the administration of valproic acid

Min-Ho Lee, Il Hong, Mingoo Kim, Byung Hoon Lee, Ju-Han Kim, Kyung-Sun Kang, Hyung-Lae Kim,

Byung-Il Yoon, Heekyoung Chung, Gu Kong, Mi-Ock Lee. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45

Aryl radical involvement in amiodarone-induced pulmonary toxicity: Investigation of protection by spin-

trapping nitrones

Adrian C. Nicolescu, Jeannette L. Comeau, Bruce C. Hill, Leanne L. Bedard, Takashi Takahashi,

James F. Brien, William J. Racz, Thomas E. Massey . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60

Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient

mice

Rizwanul Haque, Todd M. Umstead, Padmavathi Ponnuru, Xiaoxuan Guo, Samuel Hawgood,

David S. Phelps, Joanna Floros. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72

Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: Involvement

of ATM pathway

Katsura Suzuki, Kiyoshi Inageda, Gen Nishitai, Masato Matsuoka . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83

REVIEW

Mitochondrial abnormalities—A link to idiosyncratic drug hepatotoxicity?

Urs A. Boelsterli, Priscilla L.K. Lim . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92

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Volume 220, N

umber 1, A

pril 1, 2007T

oxicology and Applied P

harmacology

Pages 1–112E

LSE

VIE

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Toxicologyand Applied

Pharmacology

Volume 220, Number 1, April 1, 2007ISSN 0041-008X

“Introducing our online submission system at http://www.elsevier.com/locate/taap”

The Premier International Journal in Toxicology

Toxicology and Applied Pharmacology

CONTENTS Volume 220, Number 1, April 1, 2007

Abstracted/indexed in: BIOSIS, Chemical Abstracts, Chemical Hazards Index, Current Contents (Life Sciences, Clinical Medicine),

EMBASE, EMBiology, International Pharmaceutical Abstracts, MEDLINE®, Medical Abstracts Newsletter, Research Alert, Safety Science

Abstracts, Science Citation Index, Toxicology Abstracts. Also covered in the abstract and citation database SCOPUS®. Full text available

on ScienceDirect®.

(Contents continued on last page of this issue)