DNA REPAIR MECHANISM

Mabel Dahiana Roldan Tabares.

The development of these

methods must guarantee the

effect and safety of the patient,

and that for many people "play"

with the DNA can become an

ethical and moral problem.

The repair process is controlled

by special genes. When the

mutation occurs in these genes,

cells present synthesis and

expression that changes that

can be cause fatal diseases

Identified a molecular

target for DNA repair

defects behind

Fanconi anemia.

To test new therapies

that could prevent pre

and post natal

Fanconi anemia

conditions.

Investigators used

pluripotent stem

cells (iPSCs) and

then it was injected

into mouse models.

Stem cells were

detected in a deep G2

thanks to enzyme

(CHK1) causing

apoptosis

Using exiting

pharmacologic

inhibitors of CHK1 to

block the

hyperactive enzyme.

They prevent

apoptosis

I think these findings not only

contribute DNA repair and treatment

of some diseases, also gives a lot of

information to areas such as

pharmacology and biochemistry and

is an important step in the prevention

of hereditary diseases.

Genome-editing

technique CRISPR

allows scientists

to clip a specific

DNA sequence

and replace it with

a new one.

Offering the potential

to cure diseases

caused by defective

genes.

CRISPR system

relies on cellular

machinery that

bacteria use to

defend themselves

from viral infection.

Researchers use this system to

create gene-editing complexes

composed of a DNA-cutting

enzyme called Cas9 and a short

RNA that guides the enzyme to

a specific area of the genome.

They found in mices

that they could

correct the mutated

gene that causes

Tyrosinemia.

This CRISPR delivery

method could be used in

humans, although more

studies are needed.

I think that the development of these

new technologies are very important

for the advancement in the treatment

of diseases caused by damage or

mutation in DNA, this could also be

used to combat some agents that aim

to modify the genetic material.

These findings are important

in medicine, because we find

a greater number of people

who have genetic alterations

caused by environmental

factors (epigenetic).

This aims at the prevention

and early treatment (fetal) and

also prevent the passage of

these diseases from

generation to generation.

These results reflect the

importance of other

organisms such a bacterias to

develop new systems in the

repair of DNA, which can also

help fight diseases that cause

themselves.

• MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 8. ed. Medellín: UPB.

Fac. OF Medicina 2016. 109 p.

• Cincinnati Children's Hospital (January 13-2016) Molecule driving DNA repair

disorder revealed. MIT News. Retrieved February 12- 2016. From

http://news.mit.edu/2016/crispr-curing-disease-repairing-faulty-genes-0201

• Massachusetts Institute of Technology (February 1-2016) Curing disease by

repairing faulty genes. GEN News. Retrieved February 12- 2016. From

http://www.genengnews.com/gen-news-highlights/molecule-driving-dna-repair-

disorder-revealed/81252230/