Distributor Meeting MEDICANovember, 2009

Dr. Ariel WeiszR&D DepartmentMetrolab, Argentina

Metrolab is a company which designs and manufactures

Clinical Chemistry Analyzers with its own technology.

+ reliable instruments to the global market+ easy of use+ effective after-sale service+ competitive prices

Clinical Chemistry AnalyzersThe Principle: Spectrophotometry

Beer-Lambert LawBeer-Lambert Law

concentrationconcentration

Ab

sorb

ance

Ab

sorb

an

ce

T = P / P0

A = log10(P0 / P)

A = bc: molar absorbtivity

c: molar concentration

ColorimetryColorimetry

Samples

Reactions

Reagents

Mix Incubation(37°C)

Measure

Double beam photometerDouble beam photometer

reference detector

sample detector

beam splitter

filterlamp

reaction cuvettes

A = log(R/S)

R

S

Dual photometerDual photometer

Front sampleFront sample detector detector

reference reference detectordetector

beambeamsplitterssplitters

filterfilterlamplamp

AAFF = log(R/S = log(R/SFF))

AABB = log(R/S = log(R/SBB))SSFF

RR

Back sample Back sample detectordetector

SSBB

Clinical Chemistry AnalyzersApplications and Measuring Methods

One Reagent End PointOne Reagent End Point

A

Time

Ab

sorb

an

ce

B

R1+S

Measure = A - B

MetabolitesAlbuminGlucoseCholesterolUric acidTriglyceridesTotal proteins

AA22

TimeTime

Ab

sorb

an

ceA

bso

rban

ce

AA11

RR11+S+S RR22

BB11

BB22

Measure = (AMeasure = (A22-A-A11) – (B) – (B22-B-B11))

Two-Reagent End PointTwo-Reagent End Point

BilirubinIgA, IgG, IgMLDL, HDLPhosphorous

AA22

TimeTime

Ab

sorb

an

ceA

bso

rban

ce

AA11

RR11+S+S

BB22BB11

Measure = (AMeasure = (A22-A-A11) – (B) – (B22-B-B11))

Fixed Point KineticsFixed Point Kinetics

ALPCreatinineFructusamineUrea

KineticsKinetics

AAnn

TimeTime

Ab

sorb

an

ceA

bso

rban

ce

AA11

BBnnBB11

RR11+S+S

Measure = rateMeasure = rateAA – rate – rateBB

EnzymesAmylaseCK, CPKGGTGOTGPT

Clinical Chemistry AnalyzersMETROLAB Instruments

// Metrolab history

4000

1600 DRK

1990 1995 2000 2005

1600 PLUS 2100 2300

1600 DR

305

315

330

1985

// Current Line - Main Instruments

medium labs big labs / hospitalssmall labs

M4000

600test/hr

400

200 M2300v4

M2300GL

M1600DRv3

semiautomatic

10-40 patients/day240 test/hr

20-60+ patients/day280 test/hr

60-250+ patients/day600 test/hr

veterinary

Clinical Chemistry AnalyzersMETROLAB 4000

Troughput: 550 test/hr without ISE

• 600 test/hr single reagent

• 450 test/hr double reagent

• 720 test/hr with ISE

Split reagent trays for effective carryoverand interference control

Methods are distributed, at operator’s

will between two trays.

In this way, interfering methods never

come into contact in the same cuvette

Continuous sample load with coded sectors

Positions can be assigned to normal

samples or STATS,

Handling priorities accordingly

Positive BCR identification of samples,reagents and sectors

• Coded sectors for instantaneous load

• Any coding system for samples

• Coded reagents and optional closed system

• Open channel support

Optional ISE module: Na+, K+, Cl-

• Direct serum readings

• Indirect urine readings (dilution 1:10)

• Integrated pack for simple operation

• Automatic electrode conditioning

User friendly software with different access levels

Menu bar

Main operationcontrol tool bar

Messages list

Requests tooperator bar

Quick keys menu

Current activityand summary

Test in progress

Reagents statusreport

General status bar

Mixer in probe

• High efficiency mixing guarantees reliable data in double reagent systems and viscous media

• Shake time can be programmed for every method

72 on board cooled single reagents

R2 30 ml

R1 40ml

Outer 30 ml

Full size 70 ml

LIS Interface Connection - Customized Reports

Metrolab 4000

Monitor

PC

Monitor

PC

Data Management System

LIS

ASTM Standard serial connection

Low Water Consumption

4 mL / test

// Current Line - Main Instruments

medium labs big labs / hospitalssmall labs

M4000

600test/hr

400

200 M2300v4

M2300GL

M1600DRv3

semiautomatic

10-40 patients/day240 test/hr

20-60+ patients/day280 test/hr

60-250+ patients/day600 test/hr

veterinary

Clinical Chemistry AnalyzersMETROLAB 2300 PLUS version 4

FULLY AUTOMATIC RANDOM ACCESS CLINICAL ANALYZER

• End Point

• Kinetics

• Immunoturbidimetry

• Coagulation

• ISE

• Barcode: Samples & Reagents

• Automatic Sample Dilution

• Mixer on Probe

• Quality Control

Version 4

Samples

• 48 positions for primary tubes,

tubes 75 to 100 mm (Ø 13 mm),

accepts microtainers.

• Positive BCR identification of samples

• Test request through LIS

Version 4

Reagents

• 48 positions cooled reagent

• Bar code for reagents

• Dual reagent capability

• 50, 30 and 20 mL containers

• 24 hours non stop cooling

Version 4

Cuvette washing system

• 4-Step washing station

• Automatic cuvette check

• 6 mm light path PMMA cuvettes

Version 4

Multifunction probe

• Mixer on probe

• Collision detector

• Capacitive liquid level detection

• Effective probe washing

Version 4

Optical system

• Double beam

• 9 interference filters:

340, 405, 505, 550, 590, 650, 700 and 767 nm.

• Optional filters available (380 and 620 nm )

Version 4

Software

• User friendly

• Flexible

• Designed for the clinical analyst

• Continuous upgrade meeting your requirements

Version 4

Easy service

• Open cabinet with only 4 screws

• Calibration through PC

Version 4

// Current Line - Main Instruments

medium labs big labs / hospitalssmall labs

M4000

600test/hr

400

200 M2300v4

M2300GL

M1600DRv3

semiautomatic

10-40 patients/day240 test/hr

20-60+ patients/day280 test/hr

60-250+ patients/day600 test/hr

veterinary

Clinical Chemistry AnalyzersMETROLAB 2300 GL

Easy service

• Calibration through PC

• No cooling system

• No washing system

• No BCR

• No ISE

METROLAB 2300 GL

Quick cuvette load

• Simple and Fast

• Double tray

• One tray in use (80 cuvettes)

• Preloaded tray ready to use

METROLAB 2300 GL

Clinical Chemistry AnalyzersCommon Hints

Clinical Chemistry AnalyzersCommon Hints

• Pipetting principle

• Semi-disposable plastic cuvettes

• Low water consumption

• Probe technology

• Line style

Clinical Chemistry AnalyzersCommon Hints

• Proprietary Technology

• Proprietary software

• Open or closed customized systems

• Dedicated after-sales service

Clinical Chemistry AnalyzersNext Steps…

• Modular electronics

• Reduce manufacturing costs

• Standardization

Clinical Chemistry AnalyzersThank you for your attention !!!