distributed r&d case study: innocentive - mit …€¦ · · 2017-12-281 distributed r&d...
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Distributed R&DCase Study: InnoCentive
Managing Innovation: Emerging TrendsMassachusetts Institute of Technology
Darren J. CarrollPresident & CEO
March 3, 2005
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The Problem(s)
For Innovation-Driven Companies• Increased pressure for faster, more cost-effective R&D • Monolithic financial risk• Limited access to share of mind
For Scientists and Engineers• Retirement does not equal end of productivity• Geography trumps talent• Excess capacity has no channel for distribution
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Opportunity: A Perfect Storm for Sci/Tech Companies
Reduced inflow of foreign scientific talent
Aging U.S. scientificworkforce
ROW has surpassed U.S.in science education
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Our Key Resource:Untapped Talent Pools
Traditional poolsUS, EU AcademicsContract labs (FTE)Individual networks
Opportunity poolsGlobal AcademiaResearchers in Russia, India, China, etc.Scientists in other industriesExcess capacity Retirees
Traditional networks
Nontraditional pools of intellectual capacity
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Our Platform:How InnoCentive Works Today
InnoCentiveOperations
Seeker CompaniesSolvers
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Center of the Scientific Conversation
Scientific Operations helps you identify appropriateChallenges
Scientific Operations helpsyou formulate yourChallenges
Scientific Operations proactivelymatches the right Solver scientists with your Challenges
Scientific Operations activelyworks with Solvers to be suretheir submissions address your criteria
Scientific Operations forwardsappropriate solutions for your review
Scientific Operations facilitatesaward payment and IntellectualProperty transfer
Evaluating SolutionsTapping Global TalentDeveloping Challenges
Outcome:Challenge posted
Outcome:Submissions received
Outcome:Award given
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Scientific Disciplines of ChallengesAnalytical ChemistryCatalysisColloid ChemistryFormulation ChemistryMaterials ScienceNanotechnology
Physical ChemistryPolymer ChemistrySynthetic Chemistry
BiochemistryBiomarkersEnzymologyFood SciencePharmacologyPhysiologyPlant Biology
CHEMISTRY & APPLIED SCIENCES
LIFE SCIENCES
Organic Chemistry
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Challenge Types
Theoretical
“Paper” Chemistry
No lab work required
Reduction to Practice
“Wet Chemistry”
Requires lab work
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Solver Success Case Study
• Peroxisome-Proliferator-Activated Receptors (PPARs)
• Reduction to practice challenge
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INNOCENTIVE 3109R4-(4-HYDROXYPHENYL) BUTANOIC ACIDPOSTED: June 26, 2001DEADLINE: Nov 30, 2001$25,000USD
AbstractAn efficient synthetic strategy for the following butanoic acid derivative is required. This molecule has been previously reported in the chemical literature but the existing known synthetic route may be lengthy, expensive and/or low yielding. Devise and execute the "best synthetic pathway".
HO
OH
O
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INNOCENTIVE 3109R4-(4-HYDROXYPHENYL) BUTANOIC ACIDPOSTED: June 26, 2001DEADLINE: Nov 30, 2001$25,000USD
Solution Criteria• 2 steps or fewer • >80% overall yield• >95% purity• <$100/Kg• 2.0g white to off-white solid
HO
OH
O
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Chemistry: Complex Synthesis
HO
HO
OH
O
H2
Pd/C
O
+ OH
OHO
OH
HOAc
HO
OH
O
O
• Solution Meets Challenge Criteria:2 steps or fewer >80% overall yield>95% purityDelivery of 2.0g white to off-white solid
• Solver receives $25,000 USD!
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Our Model Works…some of the Talent Accessed• INNOCENTIVE 216128 (Protein crosslinks)
• INNOCENTIVE 3109 (R4-(4-Hydroxyphenyl) Butanoic Acid)
• INNOCENTIVE 96229 (Regio-StereocontrolledTricyclic Alcohols)
• INNOCENTIVE 258382 (Paracrystalline Arrays)
• INNOCENTIVE 55195 (Substituted isoquinoline)
Head of Indian research institute
Retired head of Hoechst R&D
N. Ireland CRO and US Professor
Outside discipline
Russian scientist
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Why Do Solution Rates Vary?
Varies Among Different Seeker Clients
Synthetic Organic Synthesis Challenges: 50%Success rate related to award level and nature of scientific problemExperimentation provides evolution
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
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Comprehensive IP Protection
1. Challenge formulation
• Trusted companies• Established IPR positions• Anonymity• Appropriate information• Confidentiality
2. Information access
• Gated details• Confidentiality/IPR agreements• Secure, private project rooms
3. Submission and award
• Solver verification• InnoCentive administers
presentation and payment• Awardees transfer IPR; all
others retain IPR
InnoCentive facilitates entire process
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Creating Value for All Participants
Seekers
Project RoadblockCapacity – cost reductionInnovationClaim StakingRevive Stalled ProjectsClose “Dead” ProjectsCulture – work outside the walls
Solvers
Intellectual challengeBusiness development opportunitiesFinancial rewardRecognition
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World’s Largest Virtual Lab
InnoCentive currently has 75,000+ Solversin 175 countries and 44 scientific disciplines
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If You Build It…… So What
Direct e-mail marketing of Challenges to targeted SolversMajor Global Program Elements• Online/Offline Advertising• Public Relations• Direct Marketing• Market Research• Thought Leader Development• Trade Shows/Conferences• Referral Program
Focus Geographies• China, India, Russia/Eastern Europe
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Solver Base Increasingly Asian
Solver Demographic December 2004
3%
37%
10%
31%
12%7% Africa & Middle East
Asia PacificE. Europe/RussiaThe AmericasSouth AsiaWestern Europe
April 2004 %
3%
30%
10%
32%
13%
12%
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4.17
6.208.13
13.86
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4.00
6.00
8.00
10.00
12.00
14.00
Tim
e
2001 2002 2003 2004
Average Length of Visit to Website
Minutes
Steady Rise in TimeSpent on Website
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Target Market: Russia
•Scientific Conferences•Public Relations•Advertising•Partnerships
•Russian Academy of Sciences•Universities
•Direct Marketing
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Target Market: India
•Advisory Board•Scientific Conferences•Public Relations•Partnerships
•IITs•CSIR, NCL, IICT•IIChE
•Direct Marketing
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Target Market: China
•Partnerships•Chinese Academy of Sciences•Universities•National Science Foundation
•Country Manager•Major Scientific Conferences •University Programs •Direct Marketing