dibip technology
DESCRIPTION
Early stage cancer diagnosis is now possible thanks to DIBIP approach.TRANSCRIPT
ISBIon Source & Biotechnologies
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Via Fantoli 16/15 (Milano)www.isbiotechnology.com
Mail to : [email protected] : Dr. Simone Cristoni
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DIBIP
DynamIc BIomarker Profile
Early stage cancer diagnosis is possible now
ISBIon Source & Biotechnologies
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Via Fantoli 16/15 (Milano)www.isbiotechnology.com
Mail to : [email protected] : Dr. Simone Cristoni
Open source Early stage cancer diagnosis through
metabolic profiling
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Apparatus for early stage cancer DiagnsosisDynamIc Biomarker Profile (DIBIP)
+
LC-MS USIS
+
OnLineDIBIPData
elaboration systemReferences
1) Cristoni S. et al. Rapid Commun Mass Spectrom. 2009 Sep;23(17):2839-452) Cristoni S. PCT International patent n. (WO 2007/131682)
Creation of different mass spectra library (ex. 2 libraries: controls and patients). The mass spectra are inserted in the correct library to create an effective database (to be enlarged by further insertion of other spectra).
Each mass spectrum represents the entire plasma peptide & metabolite profile of a person. (*, or an other biological fluid)
An unknown sample is directly compared with each single profile of the database and it is automatically allocated in one or in the other library by similarity.
CO
NTR
OLS
’ LIB
RA
RY
PA
TIE
NTS
’ LIB
RA
RY
UNKNOWN SAMPLE
The whole plasma metabolite profile of an unknown sample is directly compared with each MS spectrum of both libraries and classified by similarity.
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DIBIP data collection and elaboration description
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Plasma from control subjects
Plasma from unknown subjects
Plasma from unhealthy patients
DIBIP data DIBIP data
Control library
DIBIP data
DIAGNOSIS
DIBIP diagnosis data elaboration flow
Control library Unhealthy library
Results
94 % of Correct diagnosis!!!!!!!Sensitivity: 94%Selectivity: 94%
Results
Elaboration platform will be made freely available at:
http://www.isbiotechnology.com/
ISBIon Source & Biotechnologies
90
9.4
67
61
48
1.8
09
9
14
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.78
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19
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.13
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22
98
.37
63
24
95
.27
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.36
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.39
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3 7 6 1.
1 4 2 4
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T 16
T 12
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90
9.4
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1.8
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92
.78
42
16
81
.83
97
19
95
.13
89
22
98
.37
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24
95
.27
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27
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.36
40
28
37
.39
34
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01
.03
25
35
19
.89
90
3 7 6 1.
1 4 2 4
100
0 1
500
200
0 2
500
300
0 3
500
T 16
T 12
T 5
T7T 1
T5
90
9.4
67
61
48
1.8
09
9
14
92
.78
42
16
81
.83
97
19
95
.13
89
22
98
.37
63
24
95
.27
91
27
04
.36
40
28
37
.39
34
35
01
.03
25
35
19
.89
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3 7 6 1.
1 4 2 4
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Team
Dr. Simone Cristoni General Manager
Dr. Lorenzo Zingaro Laboratory Manager
Dr. Cristina Canton Biologist
Dr. Alessandro Finiguerra Chemist
Dr. Ombretta Repetto Biologist
Dr. Vincenza Flora Dibari Bioinformatician
Dr. Martina Soldaini Marketing
Dr. Pablo Martínez-Lozano Marie Curie researcher
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