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2/4/12FN- SCISEARCH_1974 - 9108W4AN- 11008166|GA- FZ658|TI- TECHNOLOGY-TRANSFER FROM UNITED-STATES GOVERNMENT AND UNIVERSITY

RESEARCH-AND-DEVELOPMENT LABORATORIES|LA- ENGLISH|AU- BOZEMAN B^CROW M|CS- SYRACUSE UNIV,MAXWELL SCH PUBL AFFAIRS,TECHNOL & INFORMAT POLICY

PROGRAM/SYRACUSE//NY/13244|GL- USA|SO- TECHNOVATION|SO- 1991|SO- 11|SO- N4|SO- 231-246|SO- 1991|DT- ARTICLE|NR- 0|NR- NO REFS KEYED|SF- SciSearch^CC ENGI_Current Contents, Engineering, Technology & Applied

Sciences|SC- OPERATIONS RESEARCH & MANAGEMENT SCIENCE|

AB- Despite the increased interest in domestic technology transfer, thereis surprisingly little empirical evidence on determinants of technologytransfer activity. This study presents results from a national surveyof more than 900 laboratories, focusing on a sub-sample of 134government laboratories and 139 university laboratories. Anenvironmental dependence model of technology transfer activity ispresented, arguing that influence of political authority is a majordeterminant of technology transfer activity. Tests of the modelindicated that scientific and technical mission diversity isparticularly important in understanding technology transfer to bothgovernment and industry. However, a variety of measures of politicalboundary spanning are quite important in transfer to government but notso to industry. Likewise, the nature of the resource base (government

vs. industrial) is strongly related to the choice to transfertechnology to, respectively, government and industry.||

FN- SCISEARCH_1974 - 9304W4AN- 11128975|GA- GJ472|TI- ROTATION AND INTERACTION WITH EPOXIDE HYDRASE OF CYTOCHROME-P-450 IN

PROTEOLIPOSOMES|LA- ENGLISH|AU- ETTER HU; RICHTER C; OHTA Y; WINTERHALTER KH; SASABE H; KAWATO S|CS- UNIV TOKYO,COLL ARTS & SCI,INST PHYS,MEGURO KU/TOKYO 153//JAPAN/; UNIV

TOKYO,COLL ARTS & SCI,INST PHYS,MEGUROKU/TOKYO 153//JAPAN/;

RIKEN,FRONTIER RES PROGRAM/WAKO/SAITAMA 35101/JAPAN/; SWISS FED INSTTECHNOL,DEPT BIOCHEM/CH-8092 ZURICH//SWITZERLAND/|

GL- JAPAN; SWITZERLAND|JN- JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, V266, N28, P18600-18605|PY- 1991|DT- ARTICLE|NR- 41|SF- SciSearch; CC LIFE--Current Contents, Life Sciences|SC- BIOCHEMISTRY & MOLECULAR BIOLOGY|AB- Purified rat liver cytochromeP-450MC or P-450PB was co-reconstituted

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with epoxide hydrase in liposomal vesicles made of phosphatidylcholine,phosphatidylethanolamine, and phosphatidylserine at a lipid to proteinweight ratio of 5 by the cholate dialysis procedure. Rotationaldiffusion of the cytochromes was measured by observing the decay ofabsorption anisotropy,r(t), after photolysis of the heme.CO complex bya vertically polarized laser flash.

Further analysis of the data showed that the anglebetween the hemeplaneof P-450MC and the membrane is 48-degrees or 62-degrees,different from the value of 55-degrees reported previously for P-450PB(Gut, J., Richter, C., Cherry, R. J., Winterhalter, K. H., and Kawato,S. (1983) J. Biol. Chem. 258, 8588-8594).|

ID- KeyWords Plus: RAT-LIVER CYTOCHROME-P-450; PROTEIN-PROTEININTERACTIONS; INNER MEMBRANE; PHOSPHOLIPID-VESICLES; MICROSOMALCYTOCHROME-P-450; ADRENOCORTICAL MITOCHONDRIA; ARACHIDONIC-ACID;CROSS-LINKING; DIFFUSION; OXIDASE|

CR- BENTLEY P, 1980, P647, MICROSOMES DRUG OXIDCAPDEVILA J, 1981, V78, P5362, P NATL ACAD SCI USACAPDEVILA JH, 1990, V265, P865, J BIOL CHEMWHITE RE, 1980, V49, P315, ANN REV BIOCH||