dialysis machine

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PATENTS 10 Membrane Technology January 2003 PATENTS Patents Proton conductor gas sensor Applicant: Figaro Engineering Inc, Japan A membrane electrode assembly contains a pro- ton conductive membrane sandwiched by metal plates, which are further sandwiched by ‘heat pressable’ films. Openings are formed in the ‘heat pressable’ film, and the metal plate, respectively, so that an electrode is used as the sensing elec- trode and exposed to the atmosphere to be mea- sured. Openings are also formed in the film and metal plate, respectively, so that an electrode is used as the counter electrode, and water vapour is supplied to the electrode from a water pack. Patent number: WO 02/097420 Inventors: T. Inoue, H. Okoshi, T. Nakahara, K. Kaneyasu Publication date: 5 December 2002 Supporting substrate Applicant: Apsys Advanced Particle Systems GmbH, Germany The invention relates to a supporting substrate used for the deposition, automated recognition and spectroscopic identification of particulate con- taminants in liquid or gaseous media. The sup- porting substrate structure comprises a filter mem- brane that is made from polymer materials which have a defined pore width. The surface of the filter membrane, which has a very smooth structure, is coated with metal that does not represent any spectral features for the spectroscopic identifica- tion in the selected wavelength range, and absorbs none or only a small portion of the irradiated laser energy at the selected excitation wavelength Patent number: WO 02/097400 Inventors: L. Holz, O. Valet, M. Lankers Publication date: 5 December 2002 Growth of filterable organisms Applicant: Biomed Diagnostics, USA This patent covers membrane filters and methods of trapping and culturing microorganisms. The membrane filters trap, or filter, from a sample, a specific microorganism of interest requiring a set of growth components. The membrane comprises a first subset of growth components such that the microorganism can grow and divide with the membrane contacting a medium that is made up of a second subset of growth components (defined as all components of the set of growth components that are not included in the first subset). Methods for detecting a microorganism comprise providing a membrane filter that is composed of a first subset of the set of growth components; passing the sam- ple through the filter; and placing the filter in con- tact with a medium comprising a second subset of the set of components for growth. For members of genus Legionella, a filter impregnated with activat- ed charcoal may be employed for detection and culturing. Patent number: WO 02/097052 Inventors: J.H. Hall, K. Borchardt, R.D. Hall Publication date: 5 December 2002 Tubular membranes Applicant: Pall Corp, USA An improved tubular membrane, and process of making it, are disclosed by this patent. Essentially, the process involves depositing fine metallic fibre onto a substrate. The deposited fibres are heated to form a flexible membrane. Catalytically active particles can be dispersed within the fine metallic fibres. The flexible membrane is wound to form what is referred to as a ‘membrane winding’, and this structure is then sintered to form a substan- tially rigid tubular membrane. Patent number: WO 02/096538 Inventors: N.R. Quick, M.C. Murray, M.R. June, T. Peloguin Publication date: 5 December 2002 Electrochemical cell production Applicant: Accentus Plc, UK A lithium ion polymer cell comprises an anode layer and a cathode layer each comprising respec- tive lithium ion insertion materials, separated by a porous polymeric membrane, in which the anode layer and the cathode layer each incorporates a polymeric binder. The cell is made by coating a thin porous layer of a copolymer material onto the face of the anode layer and onto the face of the cathode layer (before assembling the anode layer). The porous polymeric membrane and the cathode layer are formed into cell assembly, and this is con- tained by an enclosure. A small quantity of a liq- uid, such as acetone, is introduced into the enclo- sure, this being a solvating liquid for the copolymer material but not for the polymeric material of the membrane. The temperature is held at a slightly elevated level – at about 30°C – so the surfaces of the thin porous copolymer layers become tacky and adhere to the membrane. The solvating liquid can then be evaporated from the cell assembly, and an electrolyte solution intro- duced into the cell assembly to form a cell. This technique enables the cell components to be lami- nated without requiring the application of pres- sure, and it enables very thin membranes to be used, which are of low resistance. Patent number: WO 02/099920 Inventors: F. Coowar, V. Dass Publication date: 12 December 2002 Modified microporous membrane Applicant: Cuno Inc, USA Disclosed is a multi-layered, composite microp- orous membrane. Its structure comprises at least one layer with a highly electropositive hydrophilic material distributed throughout. The material is capable of irreversibly binding nucleic acid. Optionally, it also includes at least one layer where the material is associated with sequence-specific peptide nucleic acids, permit- ting the simultaneous or sequential capture, amplification and/or identification of specific nucleic acid sequences of interest. Also detailed by the patent are methods of use of the compos- ite membranes of the invention in applications based on the sequence-specific capture and/or amplification and identification of nucleic acid from complex biological samples. Patent number: WO 02/099139 Inventors: T.E. Arnold, M.T. Meyering, R.S. Chesterson Publication date: 12 December 2002 Dialysis machine Applicant: Gambro Lundia AB, Sweden A dialysis machine is described. It has a dialysate circuit; a blood circuit; a filter that has a dialysate compartment connected to the dialysate circuit; a blood compartment that is connected to the blood circuit; and a semipermeable membrane that is positioned in such a way that it separates the dialysate compartment from the blood com- partment. A method of filling and washing the filter comprises the recirculation of a physiologi- cal saline in the dialysate circuit and the transfer of the physiological saline from the dialysate cir- cuit to the blood circuit through the semiperme- able membrane. Patent number: WO 02/098491 Inventor: P. Rovatti, P. Pirazzoli Publication date: 12 December 2002 Recirculating tangential separation system Applicant/Inventor: B.D. Gray A method of separating a mixture into a number of more concentrated products, using recircula- tion and concentration of one product, so as to extract a substantially large fraction of another product from the mixture is described by this patent. The apparatus that uses this method is also detailed. This can be a system, such as a reverse osmosis (RO) unit that is capable of high recovery rates, efficient power usage, and long component life. Substantially 100% of the concentrate prod- uct exiting a tangential separation device (such as an RO filtering device) recirculates until the con- centration of the concentrate reaches a predeter- mined level, at which time it is purged from the system and a new cycle begins. This achieves recovery rates in RO-based water purification sys- tems from around 70% for feed water with 1000 ppm of total dissolved solids, to around 97% for feed water with 100 ppm of total dissolved solids. The method and apparatus also provide for auto- mated cleaning and maintenance of the separa- tion and filtration elements, which optimizes the service life of the components. Patent number: WO 02/098527 Publication date: 12 December 2002 Composite membrane manufacture Assignee: Lynntech Inc, USA This invention relates to methods of fabricating composite membranes in which at least one of the components is initially provided in the form of a precursor. The composite material

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PATENTS

10Membrane Technology January 2003

PATENTS

PatentsProton conductor gas sensorApplicant: Figaro Engineering Inc, JapanA membrane electrode assembly contains a pro-ton conductive membrane sandwiched by metalplates, which are further sandwiched by ‘heatpressable’ films. Openings are formed in the ‘heatpressable’ film, and the metal plate, respectively,so that an electrode is used as the sensing elec-trode and exposed to the atmosphere to be mea-sured. Openings are also formed in the film andmetal plate, respectively, so that an electrode isused as the counter electrode, and water vapour issupplied to the electrode from a water pack.Patent number: WO 02/097420Inventors: T. Inoue, H. Okoshi, T. Nakahara, K.KaneyasuPublication date: 5 December 2002

Supporting substrate Applicant: Apsys Advanced Particle SystemsGmbH, GermanyThe invention relates to a supporting substrateused for the deposition, automated recognitionand spectroscopic identification of particulate con-taminants in liquid or gaseous media. The sup-porting substrate structure comprises a filter mem-brane that is made from polymer materials whichhave a defined pore width. The surface of the filtermembrane, which has a very smooth structure, iscoated with metal that does not represent anyspectral features for the spectroscopic identifica-tion in the selected wavelength range, and absorbsnone or only a small portion of the irradiated laserenergy at the selected excitation wavelength Patent number: WO 02/097400Inventors: L. Holz, O. Valet, M. LankersPublication date: 5 December 2002

Growth of filterable organisms Applicant: Biomed Diagnostics, USAThis patent covers membrane filters and methodsof trapping and culturing microorganisms. Themembrane filters trap, or filter, from a sample, aspecific microorganism of interest requiring a setof growth components. The membrane comprisesa first subset of growth components such that themicroorganism can grow and divide with themembrane contacting a medium that is made upof a second subset of growth components (definedas all components of the set of growth componentsthat are not included in the first subset). Methodsfor detecting a microorganism comprise providinga membrane filter that is composed of a first subsetof the set of growth components; passing the sam-ple through the filter; and placing the filter in con-tact with a medium comprising a second subset ofthe set of components for growth. For members ofgenus Legionella, a filter impregnated with activat-ed charcoal may be employed for detection andculturing.

Patent number: WO 02/097052Inventors: J.H. Hall, K. Borchardt, R.D. Hall Publication date: 5 December 2002

Tubular membranesApplicant: Pall Corp, USAAn improved tubular membrane, and process ofmaking it, are disclosed by this patent. Essentially,the process involves depositing fine metallic fibreonto a substrate. The deposited fibres are heatedto form a flexible membrane. Catalytically activeparticles can be dispersed within the fine metallicfibres. The flexible membrane is wound to formwhat is referred to as a ‘membrane winding’, andthis structure is then sintered to form a substan-tially rigid tubular membrane.Patent number: WO 02/096538Inventors: N.R. Quick, M.C. Murray, M.R.June, T. Peloguin Publication date: 5 December 2002

Electrochemical cell productionApplicant: Accentus Plc, UKA lithium ion polymer cell comprises an anodelayer and a cathode layer each comprising respec-tive lithium ion insertion materials, separated by aporous polymeric membrane, in which the anodelayer and the cathode layer each incorporates apolymeric binder. The cell is made by coating athin porous layer of a copolymer material onto theface of the anode layer and onto the face of thecathode layer (before assembling the anode layer).The porous polymeric membrane and the cathodelayer are formed into cell assembly, and this is con-tained by an enclosure. A small quantity of a liq-uid, such as acetone, is introduced into the enclo-sure, this being a solvating liquid for thecopolymer material but not for the polymericmaterial of the membrane. The temperature isheld at a slightly elevated level – at about 30°C – sothe surfaces of the thin porous copolymer layersbecome tacky and adhere to the membrane. Thesolvating liquid can then be evaporated from thecell assembly, and an electrolyte solution intro-duced into the cell assembly to form a cell. Thistechnique enables the cell components to be lami-nated without requiring the application of pres-sure, and it enables very thin membranes to beused, which are of low resistance.Patent number: WO 02/099920Inventors: F. Coowar, V. DassPublication date: 12 December 2002

Modified microporous membrane Applicant: Cuno Inc, USADisclosed is a multi-layered, composite microp-orous membrane. Its structure comprises at leastone layer with a highly electropositivehydrophilic material distributed throughout.The material is capable of irreversibly bindingnucleic acid. Optionally, it also includes at leastone layer where the material is associated withsequence-specific peptide nucleic acids, permit-ting the simultaneous or sequential capture,amplification and/or identification of specific

nucleic acid sequences of interest. Also detailedby the patent are methods of use of the compos-ite membranes of the invention in applicationsbased on the sequence-specific capture and/oramplification and identification of nucleic acidfrom complex biological samples.Patent number: WO 02/099139Inventors: T.E. Arnold, M.T. Meyering, R.S.Chesterson Publication date: 12 December 2002

Dialysis machine Applicant: Gambro Lundia AB, SwedenA dialysis machine is described. It has a dialysatecircuit; a blood circuit; a filter that has a dialysatecompartment connected to the dialysate circuit;a blood compartment that is connected to theblood circuit; and a semipermeable membranethat is positioned in such a way that it separatesthe dialysate compartment from the blood com-partment. A method of filling and washing thefilter comprises the recirculation of a physiologi-cal saline in the dialysate circuit and the transferof the physiological saline from the dialysate cir-cuit to the blood circuit through the semiperme-able membrane.Patent number: WO 02/098491Inventor: P. Rovatti, P. PirazzoliPublication date: 12 December 2002

Recirculating tangential separationsystemApplicant/Inventor: B.D. GrayA method of separating a mixture into a numberof more concentrated products, using recircula-tion and concentration of one product, so as toextract a substantially large fraction of anotherproduct from the mixture is described by thispatent. The apparatus that uses this method is alsodetailed. This can be a system, such as a reverseosmosis (RO) unit that is capable of high recoveryrates, efficient power usage, and long componentlife. Substantially 100% of the concentrate prod-uct exiting a tangential separation device (such asan RO filtering device) recirculates until the con-centration of the concentrate reaches a predeter-mined level, at which time it is purged from thesystem and a new cycle begins. This achievesrecovery rates in RO-based water purification sys-tems from around 70% for feed water with 1000ppm of total dissolved solids, to around 97% forfeed water with 100 ppm of total dissolved solids.The method and apparatus also provide for auto-mated cleaning and maintenance of the separa-tion and filtration elements, which optimizes theservice life of the components.Patent number: WO 02/098527Publication date: 12 December 2002

Composite membrane manufactureAssignee: Lynntech Inc, USAThis invention relates to methods of fabricatingcomposite membranes in which at least one ofthe components is initially provided in the form of a precursor. The composite material