Accurate...Differential...Definitive...Diagnosis...

Complex Manifestations...Periodic Episodes...Overlap Syndrome

DIAGNOSISTherefore is Challenging

Resolve the complexity with

A Rational ApproachBy

COMPREHENSIVE PANELS

For

VIMTA's HEURISTICS

Screening

Monitoring

Diagnosis

Risk Prediction

Confirmation

Indicating Extent of Overlap Syndrome

AUTOIMMUNE DISORDERS- A Highly Variable Group...

CBP, ESR, Creatinine, RA, ASO, ds-DNA

?To screen for SLE, Rheumatoid Arthritis and previous Streptococcus Pyogenes Infection

?Also indicates extent of muscular and renal involvement

?Wide Spectrum of Range Offerings

?Highly specific markers combined to form Rational Panels

?Panels offering advantages of diagnosing Overlap Syndrome

?Intra and Inter Panel advantages

?Fast TAT

?Comprehensive and conclusive diagnosis in the backdrop of clinical history

ANA BLOT CAPSULE I

SLE CAPSULE

tTG AUTO HEP

ANA BLOT CAPSULE II

ANA, ds-DNA, SS-A, SS-B, RNP-G

?Useful test for complete workup of suspected SLE patients

?To diagnose SLE, spontaneous SLE, annular variety of subacute cutaneous SLE, Neonatal Lupus Erythematosus

?To help in diagnosis of mixed connective tissue disorders having features of SLE, Scleroderma and Polymyositis

ANA, AMA, ASMA, LKM-1

?Overlap of Primary Biliary Cirrhosis and Autoimmune Hepatitis

?To diagnose Primary Biliary Cirrhosis

?To distinguish Autoimmune Hepatitis from other causes of liver injury or disorder

?To screen for autoimmune diseases, chronic active hepatitis,extra hepatic biliary obstruction,non obstructive biliary tract disease,viral hepatitis and cryptogenic cirrhosis

SS-A, SS-B, RNP-G, SCL 70, JO1

?Useful panel to differentiate between SLE, Scleroderma and Inflammatory Myopathies (dermatomyositis and polymyositis)

?SS-A, SS-B and RNP are more specifically associated with SLE

?SCL-70 is a common association with Scleroderma

?JO-1 is almost exclusively associated with Inflammatory Myopathies

?Less Invasive blood test for screening celiac disease, other gluten-sensitive conditions

?Anti-tissue Transglutaminase Antibody (tTG) :

 IgA - Highly specific serologic markers for celiac diseases and dermatitis herpetiformis

?Anti-Gliadin Antibodies (AGA):

 IgG - More sensitive for screening the patients at risk for Celiac Disease and diagnosing gluten sensitive enteropathies

 IgA- monitoring patients on gluten free diets

KEY HIGHLIGHTS

CD19, CD3, CD4, CD8, CD16+56

?Enumeration of entire lymphocyte subsets by Flowcytometry: B cells, T cells (with

CD4/CD8 counts) and NK cells

?Useful assay in work up of patients born with congenital immunodeficiency states

?Useful in patients suffering from secondary immunodeficiency states induced due to

immunosuppressive therapy or HIV infection

EXTENDED IMMUNE PROFILE PANEL

COLLAGEN CAPSULE

Also Available : STAND ALONE TEST RANGE

HLA B-27 CCP ANTIBODIES

ARTHRITIS CAPSULE

ANA, ds DNA, ANCA, C3, C5, CRP, RF, UA

?To confirm diagnosis for Systemic Lupus

Erythematosus

?To diagnose Vasculitis, Rheumatoid Arthritis and

Gout

?Overlap Syndrome of Musculo-skeletal Disorders

?Disease specific autoantibody in early cases of

RA, where clinical symptoms are milder and non-

specific

?Superior to IgM RF in predicting an erosive

disease course.

?Valuable in providing diagnostic, prognostic and

therapeutic information in patients with

Rheumatoid Arthritis

?95-98% Specificity

ASO, ANA, C4, CRP, UA, Ca, RF, UR

?Panel of Biochemical and Immunological

markers to screen for diseases affecting joints

?Screening test for Autoimmune Disorders,

Rheumatoid Arthritis, Gout

?Primarily ordered to help strengthen or confirm a

suspected diagnosis of seronegative

inflammatory arthropathies like Ankylozing

Spondylitis, Reiters Syndrome and Anterior Uveitis

?Dignose and evaluate conditions causing arthritis

?Predictive Marker for Risk Assessment

?Advantage of performing the test both on PCR

and Flowcytometry

COMPREHENSIVE STAND ALONE TEST RANGE

TEST CODE

562

85

42

583

45

46

47

49

51

54

55

57

43

564

59

95

90

91

107

603

482

329

369

371

377

392

393

274

INVESTIGATION

Anti-Gliadin IgA, IgG Antibody

Acetyl Choline Receptor Antibody

Anti ds DNA Antibody-Qual, Quant

Anti Endomysial Antibody IgA, IgG

Anti Mitochondrial Antibody

Anti Mitochondrial Antibody Titre

Anti Neutrophill Cytoplasmic Antibody(p-ANCA/c-ANCA)-Qual,Quant

Anti Nuclear Antibody

Anti Nuclear Antibody -Qual, Quant

Anti Smooth Muscle Antibodies-Qual, Quant

Anti Sperm Antibodies

Anti Streptolysin O Titre

Anti TPO

Anti Transglutaminase IgA, IgG Antibodies

Anti Thyroglobulin Antibodies

c-ANCA

C3- Complement 3

C4- Complement 4

Cardiolipin Antibodies-IgA, IgG, IgM

CCP Antibodies

Circulating Immune Complex

P-ANCA

RF-IgA, IgG, IgM Antibodies

Rheumatoid Factor RA Test

Scl 70 IgG Antibodies

SS-A (Ro) IgG Antibodies

SS-B (La) IgG Antibodies

Jo-1 Antibodies

For more information on Sample Collection, contact at:

VIMTA LABS LTD.Life Sciences Facility, CLINICAL REFERENCE LABORATORY5, Alexandria Knowledge Park (Formerly S.P. Biotech Park), Genome Valley, Hyderabad- 500 078, India.Phone: +91-040-67404020, +91-040-67404040, +91-0120-2424086URL: www.vimta.com, email: helpline@vimta.com

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