Inpharma 1342 - 15 Jun 2002

Dexketoprofen trometamolprevents postoperative pain

Preoperative administration of dexketoprofentrometamol effectively reduces postoperative pain andis associated with a lower consumption of morphinerescue analgesia in patients undergoing hip arthroplasty,say researchers from Ireland.

30 such patients were randomised to receive oraldexketoprofen trometamol 25mg (n = 15), or placebo, 3times daily for 24 hours prior to, and for 48 hoursfollowing, elective hip arthroplasty under spinalanaesthesia.*

The time to first postoperative analgesia wassignificantly longer in dexketoprofen trometamol,compared with placebo, recipients (1277 vs 642 min).Cumulative postoperative morphine consumption wassignificantly less in the dexketoprofen trometamolgroup, compared with the placebo group, at 6 hours(0.06 vs 0.85mg) and at 48 hours (10.1 vs 26.2mg).Visual analogue pain scale scores were lowerthroughout the study in dexketoprofen trometamol,compared with placebo, recipients; the between-groupdifference was significant at 15 hours. The frequency ofpostoperative nausea and vomiting was lower indexketoprofen trometamol, compared with placebo,recipients; the between-group difference was significantat 18 hours. In addition, at 18 hours, sedation scoreswere significantly lower in dexketoprofen trometamol,compared with placebo, recipients. Postoperativeplasma interleukin-6 levels were similar in bothtreatment groups at 24 and 48 hours. No adverse eventswere reported after dexketoprofen trometamoltreatment.* The study was supported in part by Menarini PharmaceuticalsIreland Ltd.

Iohom G, et al. Effect of perioperative administration of dexketoprofen on opioidrequirements and inflammatory response following elective hip arthroplasty.British Journal of Anaesthesia 88: 520-526, Apr 2002 800906336

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Inpharma 15 Jun 2002 No. 13421173-8324/10/1342-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved