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Department of Biotechnology

Academic Year 2018-19

Seventh and Eighth Semesters B.E

Scheme and Syllabus

2

CONTENTS

1. Vision, Mission and Program Educational Objectives (PEO) 3 2. Program Outcomes (PO) with Graduate Attributes 4 3. Mapping of POs with PEOs 5

SCHEME 4. Scheme of Seventh Semester B.E 6 5. Scheme of Eighth Semester B.E 7

SYLLABUS

6. Syllabus of Seventh Semester BE: a) Economics & Plant Design 9-11 b) Food Biotechnology 12-15 c) Professional Elective - III 16-30 d) Professional Elective - IV 31-45 e) Professional Elective - V 46-61 f) Global Elective- II g) Mini Project

62-70 71

7. Syllabus of Eighth Semester BE: a) Global Elective – III f) Project Work

73-80 81

Appendix A Outcome Based Education 82 Appendix B Graduate Parameters as defined by National Board of Accreditation 83Appendix C Bloom’s Taxonomy 84

3

VISION

To produce competent biotechnology engineers by enabling them to achieve specific, time-bound goals and provide quality education, excellent knowledge base and relevant skill sets with the scope of continuous improvement and opportunities in Biotechnology domain.

MISSION

• Provide a holistic environment to educate the students with fundamental and advanced concepts of Biotechnology.

• Inculcate critical and lateral thinking capacities by improving their knowledge in Biotechnology allied fields through basic and applied outcome based research.

• Empower them to acquire strong ethical and intellectual capabilities along with societal and environmental awareness.

• Enable the students to develop appropriate skill sets useful both for working with multidisciplinary – heterogeneous teams and also continuing education.

Program Education objectives (PEOs)

PEO1 Solid foundation in the principles and practices of Biotechnology along with holistic knowledge in Science, Mathematics and basic Engineering.

PEO2 Develop independent thinking and problem solving capacities thereby producing good researchers with high applicability in Industry.

PEO3 Imbibe concepts of ethics, integrity, leadership and social responsibility in the graduates.

PEO4 Transform the graduates into competent performers with effective communication skills and capacities.

PEO5 Prepare graduates for their careers in Biotechnology industry or higher studies.

PEO to Mission Statement Mapping

Mission Statement PEO 1 PEO 2 PEO 3 PEO 4 PEO 5

Provide a holistic environment to educate the students with fundamental and advanced concepts of Biotechnology

3 2 1 2 2

Inculcate critical and lateral thinking capacities by improving their knowledge in Biotechnology allied fields through basic and applied outcome

2 3 2 1 2

4

based research

Empower them to acquire strong ethical and intellectual capabilities along with societal and environmental awareness

2 1 3 3 2

Enable the students to develop appropriate skill sets useful both for working with multi-disciplinary – heterogeneous teams and also continuing education

2 3 3 3 3

Correlation: 3- High, 2-Medium, 1-Low

Program Outcomes (PO) with Graduate Attributes

Graduate Attributes Program Outcomes (POs)

1 Engineering knowledge PO1: Developing profound knowledge of the fundamentals and advancements in Biotechnology domain and related engineering courses.

2 Problem analysis PO2: Analyze conditions of usefulness involved in theory and lab courses problem solving.

3 Design and Development of Solutions

PO3: Coming out with an optimized solution to the real time problems and processes.

4 Investigation of Problem PO4: Investigating the efficacy of the chosen solution and trying the same with the alternative and cost effective tools with enhanced performance.

5 Modern tool usage PO5: Enhancing the Proficiency and knowhow of the advanced techniques and testing tools in the field.

6 Engineer and society PO6: Educating and making a socially responsible Engineer with appreciable applicability towards mankind and society at large.

7 Environment and sustainability

PO7: Inculcating the consciousness about the need of protecting environment and ensuring safety to the mankind.

8 Ethics PO8: Educating the importance of being bound to ethics for the benefit of society.

9 Individual & team work PO9: Transforming into a performer capable both as an

5

individual and also as a team player.

10 Communication PO10: Developing good skills of communication for becoming a competent performer.

11 Lifelong learning PO11: Keeping updated with the recent advancements in the domain.

12 Project management and finance

PO12: Inculcating managerial skills bearing financial aspects on a project (academic / entrepreneurial).

Mapping of POs TO PEOs

PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12

PEO1 3 2 2 2 2 1 2 2 1 1 3 2

PEO2 1 3 3 3 3 1 2 1 3 2 1 2

PEO3 1 1 1 2 1 3 3 3 3 2 2 3

PEO4 2 2 2 2 2 2 1 1 2 3 2 3

PEO5 2 3 2 3 2 2 1 2 2 2 2 3

Correlation: 3- High, 2-Medium, 1-Low

6

New Horizon College of Engineering Department of Biotechnology

Scheme of VII Sem B.E Program AY: 2018-19

BTE73*: Professional Elective – III BTE731:Research Methodology BTE732:Biosimulations & Bioprocess Optimization BTE733:Molecular Farming BTE734:Medical Informatics BTE735:Synthetic Biology BTE736:Molecualr Medicine

BTE74*: Professional Elective – IV BTE741:Total Quality ManagementBTE742:Forensic ScienceBTE743:Insilico Drug DesignBTE744:Marine BiotechnologyBTE745:BiosimilarsBTE746:Genome Informatics

BTE75*: Professional Elective – V BTE751:Bioethics & BiosafetyBTE752:MetabolicEngineering BTE753:Diary BiotechnologyBTE754: Hospital Safety &ManagementBTE755:Systems BiologyBTE756:Biomedical Engineering

BTE76*: Global Elective – II BTE761: IPR & Bio-Entrepreneurship BTE762: Biomass & Biofuels BTE763: Biomaterials

S. No Course Code

Course title Credit Distribution

Ove

rall

Cred

its

Theo

ry

Cont

act

Hou

rs

Lab

Cont

act

Hou

rs Marks

L P T S CIE SEE Total

1 BTE71 Economics & Plant Design 3 1 0 0 4 3 2 75 75 150

2 BTE72 Food BIotechnology 3 1 0 0 4 3 2 75 75 150

3 BTE73* Professional Elective - III

3 0 0 1 4 3 0 50 50 100

4 BTE74* Professional Elective - IV 3 0 0 1 4 3 0 50 50 100

5 BTE75* Professional Elective

- V 3 0 0 1 4 3 0 50 50 100

6 BTE76* Global Elective - II 3 0 0 1 4 3 0 50 50 100 7 BTE77 Mini Project 0 2 0 0 2 0 4 25 25 50

TOTAL 26 18 8 350 350 750

7

New Horizon College of Engineering Department of Biotechnology

Scheme of VIII Semester B.E Program AY: 2018-19

BTE81*: Global Elective – III

BTE 811: Renewable Energy Sources BTE 812: Functional foods & Neutraceuticals BTE 813: Medical Electronics

S. No

Course Code Course

Credit Distribution

Ove

rall

Cred

its

Theo

ry

Hou

rs

Lab

Hou

rs Marks

L P T S CIE SEE Total

1 BTE81* Global Elective - III 3 0 0 1 4 3 - 50 50 100

2 BTE82 Internship 0 4 0 0 4 0 0 50 50 100

2 BTE83 Project Work 0 16 0 0 16 0 32 100 100 200

TOTAL 24 3 32 200 200 400

8

SEVENTH SEMESTER

(Syllabus)

9

ECONOMICS AND PLANT DESIGN

Course Code : BTE71 Credits : 04 L:P:T:S : 3:1:0:0 CIE Marks : 75 Exam Hours : 03+03 SEE Marks : 75 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Understand fundamentals of engineering investments and economics

CO2 Understand flowsheet synthesis and process equipment design concepts with the principles of engineering and process economics

CO3 Apply methods to quantify concepts such as fixed capital investment, cash-flow analysis, profitability analysis and decision making

CO4 Apply these in the context of a term-project that will cover design and economic evaluation of a process to produce that Bioprocess industries.

CO5 Get acquainted with Computer Aided Process Design skills through ChemCad

CO6 Analyze and evaluate the conditions to economically deal with trouble shooting problems in Bioindustries

Mapping of Course Outcomes to Program Outcomes:

PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 CO1 3 2 2 2 1 1 2 1 1 2 1 1 CO2 3 2 2 2 1 1 2 1 1 2 1 1 CO3 3 2 2 2 1 1 2 1 1 2 1 1 CO4 3 2 2 2 1 1 2 1 1 2 1 1 CO5 3 2 2 2 1 1 2 1 1 2 1 1 CO6 3 2 2 2 1 1 2 1 1 2 1 1

Module No

Module Contents Hours Cos

1

Introduction Basic considerations in chemical plant design, project identification, preliminary techno-economic feasibility. Process flow Diagrams and symbols: Symbols of Process Equipments & their concepts, types of flow diagrams, Importance of Laboratory development pilot plant, scale up methods

1. Process Equipment Symbols 2. Process flow diagram

9

CO1 CO2 CO3

2

Detailed process design Basic engineering in process, thermodynamic and kinetic feasibility, capacity identification and selection, process specification, equipment specification material selection, plant safety operation and maintenance, Plant location and layout: Factors affecting site selection, factors affecting both planning and layouts, drawing of plant layout, plant elevation drawing and complete engineering

9 CO2 CO3 CO4

10

flow sheet drawings 1. Plant layouts and elevations 2. Engineering Flow sheet drawings

3

Piping Design & Layout Piping design, layout, and supports for piping insulations. Pipe fittings, types of valves, selection of valves, process control and instrumentation control system design. Pipe size estimation, water hammer design of pipelines, Isometric of piping, material selection for pipe and pipe fitting, expansion and contraction of piping, thermal insulation of piping, color code of pipeline, bill of material of piping. Process utilities Process water, boiler feed water, water treatment, waste treatment and disposal, disposal, steam, oil heating system, chilling plant, compressed air and vacuum. 1. Piping and instrumentation diagram 2. Bioprocess calculations Problems (eg : Mixing

problem,Distillation ,Crystallizatiion)

9 CO4 CO5

4

Cost estimation Factors involved in project cost estimation - Total capital investment, Fixed capital and working capital, types and methods for estimation of total capital investment, Estimation of equipment cost Project scheduling and Financial Management CPM/PERT techniques, project engineering, project planning, plant erection, testing and commissioning

1. Cost estimation problems 2. CPM/PERT Techniques

9 CO1 CO2 CO5

5

Profitability, alternative investments and replacement Methods for profitability evaluation, Evaluation of Break Even Point, % rate of return, Practical factors in alternative investment and replacement studies. Depreciation: Types and methods of determining depreciation, evaluation of depreciation methods.

1. Break even analysis 2. Problem solving Techniques : Case Studies

9

CO1 CO4 CO5 CO6

Text Books:

1. Plant design and Economics for chemical engineers, peter M. S. Timmerhaus, K. D., 5th edn, McGraw Hil, ISBN 10: 0071240446 ,2003.

2. Project Engineering with CPM and PERT, Modes J. Philips, 2nd edn, Rheinhold publishers, ISBN-10: 0442254156,1970.

Reference books: 1. Analysis synthesis and design of chemical processes, Turton et al 3rd edn, Prentice

Hall, ISBN 13: 9788120349612,1998. 2. Bioprocess Engineering’ 2nd edition, M.L.Shuler and F.Kargi, Prantice Hall India, New

Delhi, ISBN : 0-13-081908-5,2002

11

3. Chemical Engineering Design, 1st Edition Gavin Towler R K Sinnott Gavin Towler R K Sinnott, Butterworth- Heinemann, ISBN: 9780080556956, 2007

4. Food Plant Economics, 1st edition, Zacharias B. Maroulis, George D. Saravacos, CRC press, ISBN 9781420005790

Assessment Pattern CIE- Continuous Internal Evaluation: Theory (50 Marks)

Bloom’s Category Tests Assignments Quizzes Curricular /Cocurricular

Marks (out of 50) 25 10 5 10 Remember 5 - 2 - Understand 5 5 2 5 Apply 10 5 1 5 Analyze 5 - - - Evaluate - - - - Create - - - - CIE- Continuous Internal Evaluation: Lab (25 Marks) Bloom’s Category Tests Marks(Out of 50) Remember -- Understand 10 Apply 10 Analyze 5 Evaluate - Create - SEE- Semester End Examination Theory (50 Marks) Bloom’s Category Tests Marks(Out of 50) Remember 10 Understand 20 Apply 10 Analyze 10 Evaluate - Create - SEE- Semester End Examination Lab (50 Marks) Bloom’s Category

Tests Marks(Out of 50) Remember 10 Understand 20 Apply 10 Analyze 10 Evaluate - Create -

12

FOOD BIOTECHNOLOGY Course Code : BTE72 Credits : 04 L:P:T:S : 3:1:0:0 CIE Marks : 75 Exam Hours : 03+03 SEE Marks : 75 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Remember & identify the various food groups, nutrient components (macro and micro) and their proximate composition.

CO2 Understand the various microbes associated with foods and food groups and identify their role in food spoilage, processing & preservation.

CO3 Understand the concepts, principles and procedures involved in the area of fermented food production.

CO4 Understand the role of different methods of preservation on foods and their impact on the shelf life, quality, and other physical and sensory characteristics of foods.

CO5 Procure a thorough Knowledge of food hazards viz., physical, chemical and biological in the industry and food service establishments.

CO6 Develop a profound awareness about food safety, quality and the different regulatory and statutory bodies in India and the world for food safety.

Mapping of Course Outcomes to Program Outcomes: PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 CO1 3 2 2 2 1 2 2 3 1 1 2 2 CO2 3 2 2 2 1 2 2 3 1 1 2 2 CO3 3 2 2 2 1 2 2 3 1 1 2 2 CO4 3 2 2 2 1 2 2 3 1 1 2 2 CO5 3 2 2 2 1 2 2 3 1 1 2 2 CO6 3 2 2 2 1 2 2 3 1 1 2 2

Module No


1

Food Chemistry & Microbiology Overview of Carbohydrates, Proteins, Lipids, Water, Minerals, Vitamins, Colour, Flavour & Aroma components and other components - Naturally occurring toxic substances, protease inhibitors. Food groups, proximate composition, food composition tables- uses. Factors affecting spoilage of foods, Microbial flora associated with various food groups their spoilage potential. Microbiological spoilage problems associated with typical food products. Use of antimicrobial chemical & physical methods. Food borne infections and food poisoning, Microbial toxins – types. Detection & Enumeration of microbes in foods.

9 CO1 CO2

13

Lab: 1. Preparation of emulsions 2. Microbiological quality of water (MPN) & Milk.

2

Introduction to Food Processing Source of food - food of plant, animal and microbial origin; different foods and groups of foods as raw materials for processing. Methods of food handling & storage, Large scale food processing, food wastes in various processes, Food hygiene - Food adulteration – definition, common food adulterants, contamination with toxic metals, pesticides and insecticides Lab:

1. Estimation of Acid Value and Peroxide value of Edible oils and Assessment of Rancidity.

2. Enzymatic Browning in foods

9 CO2

3

Food Fermentation Processes History of food fermentations - types of fermented foods and substrates/raw materials used, Fermenting organisms and their role - microorganisms of importance in food fermentations, Biochemistry of fermentations/fermentation pathways, Fermented food products - Dairy fermentations Yeast fermentations - Wine and beer fermentations, bread making, Fermentation production of flavor components, acids, alcohol, enzymes, pigments/colours. Lab:

1. Calculation and Computing of nutrient composition of foods

2. Estimation of Vitamin C in Fruit juices.

9 CO3

4

Food Preservation Technology General principles of preservation, classification of methods used for preservation. Principles of storage using low temperature. Principles of canning and bottling of foods. Non-thermal methods - Chemical preservatives, preservation by ionizing radiations, ultrasonics, high pressure, fermentation, curing, pickling, smoking, membrane technology. Basic packaging materials, types of packaging, packaging design, packaging for different types of foods, retort pouch packing, costs of packaging and recycling of materials. Lab:

1. Effect of heat on proteins 2. Iso-electric precipitation of casein

9 CO4

5

Food Safety, Quality and Regulation Definition of food safety and concept of safe food; characterization of food hazards physical, chemical and biological. Microbial hazards and natural source hazards in

9 CO5 CO6

14

food. Monitoring & regulation - HACCP, GMP; Surveillance networks, Consumer and food service operator education, Function and roles of USFDA, USDA and EPA, Food Safety and Standards Act India 2006; Special foods - Infant foods, formula foods, fortified foods, sports nutrition, nutraceuticals, medical foods. Lab:

1. Enumeration of Lactic acid bacteria from fermented foods.

2. Enumeration & Isolation of Staphylococci from ready to eat street foods

Text Books:

1. Belitz H.-D, Grosch W and Schieberle P. Food Chemistry, 3rd Revised Edition, Springer-Verlag, 2004. ISBN: 3540408177, 9783540408178

2. Chopra, H.K. and P.S. Panesar. “Food Chemistry”. Narosa, 2010. ISBN: 8184870396, 9788184870398

Reference books:

1. Lee, B.H., 2014. Fundamentals of food biotechnology. John Wiley & Sons. 2nd Edition. ISBN: 1118384938, 9781118384930

3. Pometto, A., Shetty, K., Paliyath, G. and Levin, R.E. eds., 2005. Food biotechnology. CRC Press. 2nd Edition. ISBN: 1420027972, 9781420027976

4. Ray, B. and Bhunia, A., 2007. Fundamental food microbiology. CRC press. 5th Edition. ISBN: 146656444X, 9781466564442

5. Sivasankar, B., 2002. Food processing and preservation. PHI Learning Pvt. Ltd. ISBN: 8120320867, 9788120320864

Assessment Pattern

CIE- Continuous Internal Evaluation: Theory (50 Marks)

Bloom’s Category Tests Assignments Quizzes Curricular /Cocurricular

Marks (out of 50) 25 10 5 10 Remember 10 - 2 - Understand 5 5 2 5 Apply 5 5 1 5 Analyze 5 - - - Evaluate - - - - Create - - - -

15

CIE- Continuous Internal Evaluation: Lab (25 Marks) Bloom’s Category Tests Marks(Out of 50) Remember -- Understand 10 Apply 10 Analyze 5 Evaluate - Create - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category Tests Marks(Out of 50) Remember 20 Understand 20 Apply 5 Analyze 5 Evaluate - Create - SEE- Semester End Examination: Lab (50 Marks) Bloom’s Category


16

PROFESSIONAL ELECTIVE – III

RESEARCH METHODOLOGY Course Code: BTE731 Credits : 04 L: P: T: S: 3:0:0:1 CIE Marks : 50 Exam Hours: 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Understand the basics of research methodologies CO2 Understand different steps in design of an experiment CO3 Understand different data collection methods CO4 Understand different data analysis methods CO5 Understand the basics of professional communication CO6 Apply and analyze the importance of professional communication



Module No

Module Contents Hours COs

1

Introduction to Research: The hallmarks of scientific research – Building blocks of science in research – Concept of Applied and Basic research – Quantitative and Qualitative Research Techniques – Need for theoretical frame work – Hypothesis development – Hypothesis testing with quantitative data. Research design – Purpose of the study: Exploratory, Descriptive, Hypothesis Testing.

9 CO1

2

Experimental Design: Laboratory and the Field Experiment – Internal and External Validity – Factors affecting Internal validity. Measurement of variables – Scales and measurements of variables. Developing scales – Rating scale and attitudinal scales – Validity testing of scales – Reliability concept in scales being developed – Stability Measures.

9 CO2

3

Data Collection Methods: Interviewing, Questionnaires, etc. Secondary sources of data collection. Guidelines for Questionnaire Design – Electronic Questionnaire Design and Surveys. Special Data Sources: Focus Groups, Static and Dynamic panels. Review of Advantages and Disadvantages of various Data-Collection Methods and their utility. Sampling Techniques – Probabilistic and non-probabilistic samples. Issues of Precision and Confidence in

9 CO3 CO4

17

determining Sample Size. Hypothesis testing, Determination of Optimal sample size.

4

Data Analysis – Factor Analysis – Cluster Analysis – Discriminant Analysis – Multiple Regression and Correlation – Canonical Correlation – Application of Statistical (SPSS) Software Package in Research.

9 CO3 CO4

5

Introduction to professional communication– Concept of audience – Basics of written reports. Integral parts of a report – Title of a report, Table of contents, Abstract, Synopsis, Introduction, Body of a report – Experimental, Results and Discussion – Recommendations and Implementation section – Conclusions and Scope for future work

9 CO5 CO6

TEXT BOOKS:

1. Donald R. Cooper and Ramela S. Schindler, Business Research Methods, Tata McGraw- Hill Publishing Company Limited, New Delhi, 2000. ISBN: 9781259001857

2. Uma Sekaran, Research Methods for Business, John Wiley and Sons Inc., New York, 2000. ISBN-13: 978-0471618898

REFERENCE BOOKS: 1. G.W.Ticehurst and A.J.Veal, Business Research Methods, Longman, 1999.ISBN 10:

0582811228 2. Ranjit Kumar, Research Methodology, Sage Publications, London, New Delhi, 1999. ISBN

:1741032539 3. C.R.Kothari, Research Methodology, Wishva Prakashan, New Delhi, 2001. ISBN

(3):978812242481 4. Donald H.McBurney, Research Methods, Thomson Asia Pvt. Ltd. Singapore, 2002.

ISBN 978-0495092087 CIE- Continuous Internal Evaluation: Theory (50 Marks)

Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10

Remember 05 - 2 - Understand 05 4 2 4 Apply 10 4 1 4 Analyze 05 2 - 2 Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category


18

BIOSIMULATION AND BIO PROCESS OPTIMIZATION

Course Code : BTE732 Credits: 04 L: P: T: S : 3:0:0:1 CIE Marks: 50 Exam Hours : 03 SEE Marks: 50

Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Procure broad knowledge on the various biosimulation tools applied in the bioprocess optimization.

CO2 Understand the Importance of various Biosimulation tools applied in the Bioprocess optimization.

CO3 Apply the biosimulation tool Plackett-Burman design in bioprocess optimization studies

CO4 Apply the biosimulation tool Response Surface Methodology design in bioprocess optimization and analyze the results by performing the ANOVA.

CO5 Analyze the results (PBD and RSM) by imbibing the CCD-ANN validation design

CO6 Evaluate the Genetic Fitness of the bioprocess and the cultures applied through Genetic algorithm design.


Module No


1

Biosimulation in Bioprocess: Biosimulation terminologies, Conventional optimization methods and their limitations, Nonlinear relationship and Impact, Biosimulation models applied: Role, advantageous over conventional methods, Different types: Plackett-Burman Design, Response Surface Methodology and ANOVA, Artificial Neural Network and Importance of validation studies, Genetic Algorithm and Genetic fitness analysis.

9 CO1 & CO2

2

PLACKETT-BURMAN DESIGN: Introduction, Design types: Full Factorial Design, Minimum Run Factorial Design, Multi Level Categoric Design, Split Plot Design, Software’s used, installation and working procedure, Result Analysis, Case Studies with Demonstration, Advantages, Disadvantages and

9 CO1 & CO3

19

applications.

3

RESPONSE SURFACE DESIGN: Introduction, Different types of design models: Central composite design (CCD), Box benhkhen’s Design (BBD), Miscellaneous Design, Historical Data, User-Defined Design, Analysis of Results, Software’s employed, Installation procedure, Example with demonstration, Result Analysis, Case studies, Advantages, disadvantages and applications.

9 CO1 & CO4

4

ARTIFICIAL NEURAL NETWORK: Introduction, Network Types: Multilayer Percepton, Back Propagation, Analysis of Results, Softwares: MATLAB and MINITAB, Installation, Nnstart, Cftool, Sftool, Example with Demonstration. MATLAB examples, Regression analysis and validation studies, Neuroph software, Installation, Topological diagram, Case studies.

9 CO1 & CO5

5

GENETIC ALGORITHM: Introduction, Genetic Algorithm Terminology, Performing Genetic Algorithm Optimization, Rastrigin’s Function, Genetic Algorithm Optimization tool GUI, working principle, Examples- Population Diversity, Fitness Scaling, Mutation and Crossover. Comparing Results for Varying Crossover Fractions, Global vs. Local Minima with GA.

9 CO1 & CO6

Text Books:

1. Bioprocess Engineering Principles by Pauline M. Doran Ph.D. Professor (Author), Academic Press Ltd, Second Edition, 2012, London, UK, ISBN0122208552.

2. Principles of Fermentation Technology by P.F. Stanbury, A Whitkar and S.J. Hall, Elsevier Publications, Third Edition, 2016, University of Hertfordshire, England, ISBN 9780080999531

Reference Books:

1. Industrial Biotechnology Hardcover by by Abhilasha S Mathuriya, Ane Books Pvt. Ltd. First Edition, 2009, ISBN10: 8180521419.

2. Biochemical Engineering, by Douglas S. Clark ‎, Harvey W. Blanch, Marcel Dekkar Publishers, Second Edition, 1997, New York, USA, ISBN0824700996.

3. Bioprocess Engineering by Michael L. Shuler, Fikret Kargi , Pearson publishers, second edition, 2015, ISBN-10: 0130819085

4. Biotechnology and Bioprocess Engineering by Dr C M Narayan, Galgotia Publications Pvt Ltd, First Edition, 2011, ISBN-10: 8175156333.

Assessment Pattern

CIE- Continuous Internal Evaluation: Theory (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 - - - Understand 10 - - - Apply 05 5 - 5

20

Analyze - 5 5 5 Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category

Tests Marks (out of 50) Remember 10 Understand 15 Apply 15 Analyze 10 Evaluate - Create -

21

MOLECULAR FARMING



CO1 Procure broad knowledge on the various accepts of Molecular farming their applications in Biotechnology Industry.

CO2 Remember different plant tissue culture techniques and understand the mechanism foreign gene expression in plants.

CO3 Apply the knowledge of Genetic Engineering principles and rDNA technology to create novel seeds

CO4 Get equipped with the essential knowledge on the design and development of genetically modified monocots with commercial applications.

CO5 Understand and analyze the pivotal role of plantibodies and edible vaccines in modern medicine.

CO6 Develop awareness on various downstream processing methodologies of plant derived products.


Module No


1

PLANT TISSUE CULTURE and GENE EXPRESSION: Introduction to plant tissue culture, suspended cultures, hairy root cultures, shoot teratoma cultures. foreign protein (FP) production systems Strategies for improving FP production in tissue culture, expression systems, modifications to existing expression constructs, secretion of foreign proteins, foreign protein stability, stability inside the cells.

9 CO1 & CO2

2

RECOMBINANT SEED Technology: Biology of sprouting, dicotyledonous seeds, germination, sprout, rubisco synthesis, rubisco promoters, inhibition of endogenous gene expression, expression cassette design, sprouting- equipments, conditions, sterilization, time and temperature, light, inhibition of endogenous gene expression, growth regulators, nitrogen fertilizer, seed production, quality and

9 CO1 & CO3

22

environmental aspects.

3

GENETICALLY MODIFIED MONOCOTS: Cereal production crops, Technical aspects, cereal transformation, expression construct design, Prodigene and Maize. Recombinant proteins expressed in Rice, Wheat, Barley. Plant RNA viruses as expression vectors- TMV, PVX, CPMV, AIMV. Biological activity of target molecules, efficacy of plant virus antigens, vaccine antigens- particle based.

9 CO1 & CO4

4

PLANTIBODIES AND EDIBLE VACCINES: Introduction, expression of therapeutic and human proteins in plants, transgenic chloroplast system, chloroplast derived human antibodies, biopharmaceuticals, Human Serum Albumin, Human insulin like growth factor-1, Human interferon, Antimicrobial peptides, chloroplast derived vaccine antigens, cholera toxin B subunit, Bacillus anthracis protective antigen, Yersinia pestis F1-V fusion antigen, Canine Parvovirus VP2 protein.

9 CO1 & CO5

5

PLANT DERIVED RECOMBINANT THERAPEUTIC PROTEINS : Similarities and differences in the processing of pharmaceutical proteins from different sources, process scale, individual steps of a Downstream process, Initial processing and extraction, chromatographic purification, regulatory requirements for downstream processing of plant derived products.

9 CO1 & CO6

Text Books: 1. Molecular farming: Plant-made Pharmaceuticals and Technical Proteins by Rainer

Fischer and Stefan Schillberg. Wiley-VCH Verlag GmbH and Co. KGaA. Weinheim, First Edition, 2005. ISBN: 9783527307869, FRG. doi: 10.1002/3527603638.

2. Molecular Farming by Amita Sarkar, Discovery Publishing House Pvt. Ltd, Firat Edition, 2009, ISBN: 9788183564205, 8183564208

Reference Books:

1. Molecular Approaches For Plant Fungal Disease by H.P. Singh ,‎ P. Chowdappa , Westville Publishing House, First Edition, 2012, ISBN-10: 8185873844.

2. Transgenic Plants: Methods and Protocols (Methods in Molecular Biology), Edited by Jim M. Dunwell,‎ Andy C Wetten, Humana Press; 2nd edition. 2012, ISBN-10: 1617795577

3. Molecular farming in plants: Recent advances and future prospects Edited by Aiming Wang Shengwu Ma, Springer publishers, First Edition, 2012, Dordrecht Heidelberg London New York, ISBN 978-94-007-2216-3 e-ISBN 978-94-007-2217-0, DOI 10.1007/978-94-007-2217-0

4. Biochemistry and Molecular Biology of Plants, by Bob B. Buchanan,‎ Wilhelm Gruissem (Editor),‎ Russell L. Jones (Editor), Wiley publications, Second Edition, American Scoiety of plant biologist. ISBN 9780470714218.

23

Assessment Pattern

CIE- Continuous Internal Evaluation: Theory (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 - - - Understand 10 - - - Apply 05 5 - 5 Analyze - 5 5 5 Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category Tests Marks (out of 50) Remember 15 Understand 15 Apply 10 Analyze 10 Evaluate - Create -

24

MEDICAL INFORMATICS Course Code : BTE734 Credits : 04 L: P: T: S: 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Know the basics of medical informatics, hospital management and information system.

CO2 Understand the fundamentals and applications of hospital management and information science.

CO3 Understand and apply computer assisted medical education & surgery.

CO4 Analyze and apply new and emerging technologies promote students to make use of surgical simulation and virtual environment.

CO5 Learn and evaluate modern medical system by telecommunication based systems.

CO6 Create modern systems and tools through medical informatics to communicate and treat data very rapidly.



Module No


1

MEDICAL INFORMATICS: Aim and scope, salient feature, Introduction, history, definition of medical informatics, bio-informatics, online learning, introduction to health informatics, prospectus of medical informatics. HOSPITAL MANAGEMENT AND INFORMATION SYSTEMS: Central Registration Module, OPD / Consultant Clinic / Policlinic Module, Indoor Ward Module, Patient Care Module, Procedure Module, Diet Planning Module, MLC Register Module, Pathology Laboratory Module, Blood Bank Module, Operation Theatre Module

9 CO1

2

HOSPITAL MANAGEMENT AND INFORMATION SCIENCE: Introduction, HMIS: need, Benefits, capabilities, development, functional areas. Modules forming HMIS, HMIS and Internet, Pre-requisites for HMIS, PACS, why HMIS fails, health information system, disaster management plans, advantages of HMIS.

9 CO2

3

COMPUTER ASSISTED MEDICAL EDUCATION & SURGERY: CAME, Education software, Tele-education, Tele-mentoring, CAPE, patient counseling software. Limitation of conventional surgery, computer assisted surgery (CAS), 3D navigation system, intra-operative imaging for 3D navigation system, merits and demerits of CAS.

9 CO3 CO6

4 SURGICAL SIMULATION AND VIRTUAL ENVIRONMENT: Need, technology, volume image data file, human resources, interface and 9

CO4 CO6

25

applications. Virtual environment (VE), technology, applications of VE, advantages of simulators and after effects of VE participation

5

TELECOMMUNICATION BASED SYSTEMS: Telemedicine, need of telemedicine, technology materials and methods, internet, applications of telemedicine, reliability and cost analysis, tele-surgery, robotic surgery, needs for tele-surgery, advantages and disadvantages, technology materials and methods, applications.

9 CO5 CO6

TEXTBOOK:

1. Medical Informatics: A Primer - by Mohan Bansal, 1st Print, Tata McGraw Hill, Publications, 2003, ISBN 0070444986, 9780070444980

2. Medical Informatics: Computer applications in health care and biomedicine by Edward H. Shortliffe, James J. Cimino, Springer Science & Business Media, 2013, ISBN 1447144740, 9781447144748

REFERENCE BOOKS:

1. Handbook of Medical Informatics by J.H.Van Bemmel, Stanford University Press/Springer, 2000, ISBN 3540633510, 9783540633518.

Assessment Pattern CIE- Continuous Internal Evaluation (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 2 2 5 Understand 10 1 2 3 Apply 5 2 1 2 Analyze - - - - Evaluate - - - - Create - - - - SEE- Semester End Examination (50 Marks) Bloom’s Category Tests Marks(Out of 50) Remember 20 Understand 15 Apply 10 Analyze - Evaluate - Create -

https://www.google.co.in/search?tbo=p&tbm=bks&q=inauthor:%22Edward+H.+Shortliffe%22&source=gbs_metadata_r&cad=7

https://www.google.co.in/search?tbo=p&tbm=bks&q=inauthor:%22James+J.+Cimino%22&source=gbs_metadata_r&cad=7

26

SYNTHETIC BIOLOGY

Course Code : BTE735 Credits : 04 L: P: T: S: 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Define synthetic biology and new aspects CO2 Understand varies pathways and tools CO3 Understand the concept of computational protein design CO4 Get acquainted with the software’s and computer aided design CO5 Evaluate the application of synthetic biology CO6 Understand and apply the concepts in future aspects



Module No


1 Introduction:

Synthetic Biology: What is in a Name?, What’s New?, What’s Next?, Synthesis and Engineering Tools in Synthetic Biology, New Tools for Cost-Effective DNA Synthesis, Oligonucleotide Synthesis, Gene Assembly, Quality Control, Applications of DNA Synthesis

9 CO1

2. Protein Engineering & pathway engineering as an Enabling Tool for Synthetic Biology: Protein Engineering: Introduction, Protein Engineering Methods, Applications of Protein Engineering in Synthetic Biology Pathway Engineering: Introduction, Design and Construction of Pathways, Pathway Optimization, Applications of Pathway Engineering Tools

9 CO2

3. Computational Protein Design for Synthetic Biology: Introduction, Methods Overview, Computational Design of Protein–protein Interactions, Computational Design of Catalytic Activity, Protein Thermostabilization by Computational Design, Computational Design of (Novel) Protein Folds, Complementarity with Directed Evolution Methane).

9 CO3

27

DNA Size Limit by E. coli Plasmid, Genome Cloning Using a Bottom-Up Approach, The KEIO Method, Mitochondria and Chloroplast: Organelle Guest Genomes in BGM, Bottom-Up Approaches for De Novo Genome Production, Costs to Synthesize Genomes, Relevant Methods to Support Genome Synthesis

4. Computer-Aided Design of Synthetic Biological Constructs with the Synthetic Biology Software Suite: Introduction, Synthetic Logical-AND Gates and Protein Devices, The Synthetic Biology Software Suite, Computational Prediction Tools for Synthetic Biology Components, Computational Tools for Pathway Prediction, Computational Tools for Strain Optimization, Synthetic Biology for Systems-Level Metabolic Engineering

9 CO4

5. Applications in Synthetic Biology: Target Organisms and Cell Types for Therapeutic, Applications of Synthetic Biology, Molecular Toolkit for Synthetic Biology, Therapeutic Applications of Synthetic Biology, Conclusion: Challenges and Safety Issues

9 CO5, CO6

TEXT BOOKS

1. Synthetic Biology: Tools and Application, Huimin Zhao, 2013, Academic Press, ISBN:

9780123944306

2. An Introduction to Systems Biology: Design Principles of Biological Circuits, Uri Alon,

2006, CRC Press, ISBN 9781584886426

REFERENCE BOOKS

1. Synthetic Biology - A Primer, Baldwin, Bayer, Dickinson, Ellis, 2012, Imperial College

Press, ISBN: 9781783268788

Assessment Pattern CIE- Continuous Internal Evaluation (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 2 2 5 Understand 10 1 2 3 Apply 5 2 1 2 Analyze - - - - Evaluate - - - - Create - - - -

28

SEE- Semester End Examination (50 Marks) Bloom’s Category Tests Marks(Out of 50) Remember 20 Understand 15 Apply 10 Analyze - Evaluate - Create -

29

MOLECULAR MEDICINE

Course Code : BTE736 Credits : 04 L: P: T: S: 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Learn basic concepts of molecular biology and molecular medicine CO2 Understand the molecular mechanism of various oncology CO3 Understand the molecular mechanism of virology CO4 Get acquainted with the knowledge of various methods employed in molecular medicine CO5 Understand the concept of drug intake CO6 Apply the various molecular methods in multiple fields of molecular medicine



Module No


1 Introduction: The basics of molecular medicine, Stages of drug development, the human cell, DNA Replication and Gene expression, Biological Communication, The immune system

9 CO1

2. Molecular Oncology: Molecular biology of breast cancer and its clinical implications, Hepatocellular carcinoma, Colorectal cancer and its clinical implications, Renal cell carcinoma

9 CO2

3. Molecular Virology: The basics of virology: human immunodeficiency virus, Hepatitis B virus, Influenza virus, Vaccination: Live vaccine, recombinant virus vaccine, subunit vaccine, DNA vaccines, HIV vaccines, Detection of virus: cytopathic effects, Electron microscopy, hemagglutination assay, ELISA, antiviral susceptibility testing, Antiviral therapy: HIV, Hepatitis C virus, influenza virus, Prions

9 CO3, CO6

4. Methods in Molecular Medicine: DNA microarrays, Quantitative PCR, Next Generation sequencing, Animal models in biomedical research,

9 CO4, CO6

30

Methods: Fluorescence microscopy, Flow cytometry and FACS, SPR, Gene testing, Chromosomal abnormalities, conventional Karyotyping, FISH, Comparative genomic hybridization

5. Pharmacogenetics & Pharmacogenomics: Uptake and Transport of Drugs: Drug metabolism, cytochrome p450 enzymes, Drug targeting, Drug toxicity and hypersensitivity, drug development and individual pharmacotherapy

9 CO5

TEXT BOOKS

1. Molecular Medicine: An Introduction, Jens Kurreck, Cy Aaron Stein Wiley-VCH, ISBN

No: 9783527331895

2. Principles of Molecular Medicine, Marschall S Runge, Cam Patterson, Victor A

McKusick, Humana Press, 2006, ISBN No. 1588292029

REFERENCE BOOKS

1. Molecular Medicine: Genomics to Personalized Healthcare, Ronald L Trent, Elsevier,

2012, ISBN No. 9780123814517

2. Introduction to molecular Medicine, Denis W Ross, Springer Science- Business Media

LLC, 1992, ISBN No. 9780387977249

31

PROFESSIONAL ELECTIVE – IV

TOTAL QUALITY MANAGEMENT

Course Code: BTE741 Credits: 04 L: P: T: S: 3:0:0:1 CIE Marks: 50 Exam Hours: 03 SEE Marks: 50

Course Outcomes: At the end of the Course, the Student will be able to CO1 Understand the various principles, practices of TQM to achieve quality CO2 Learn the various statistical approaches for Quality control CO3 Understand the TQM tools for continuous process improvement CO4 Apply the TQM tools for real industrial applications CO5 Understand quality, systems, tools and techniques CO6 Learn the importance of ISO and Quality systems Mapping of Course Outcomes to Program Outcomes:


Module No Module Contents Hours Cos

1

Introduction Introduction - Need for quality - Evolution of quality - Definition of quality - Dimensions of product and service quality - Basic concepts of TQM – TQM Framework - Contributions of Quality Gurus – Barriers to TQM – Cost of Quality.

9 CO1

2

TQM Principles Quality statements - Customer focus –Customer orientation, Customer satisfaction, Customer complaints, Customer retention - Continuous process improvement – PDCA cycle, 5s, Kaizen - Supplier partnership – Partnering, Supplier selection, Supplier Rating

9 CO2

3

TQM Tools & Techniques I The seven traditional tools of quality – New management tools – Six-sigma: Concepts, methodology, applications to manufacturing, service sector including IT – Bench marking – Reason to bench mark, Bench marking process – FMEA – Stages, Types.

9 CO3 CO4

4 TQM Tools & Techniques II 9 CO4

32

Quality circles – Quality Function Deployment (QFD) – Taguchi quality loss function – TPM – Concepts, improvement needs – Performance measures - BPR.

CO5

5

Quality Systems Need for ISO 9000- ISO 9000-2000 Quality System – Elements, Documentation, Quality auditing- QS 9000 – ISO 14000 – Concepts, Requirements and Benefits –Quality Council – Leadership, Employee involvement – Motivation, Empowerment, Team and Teamwork, Recognition and Reward.

9 CO6

Text Books: 1. Besterfiled, Dale H. et al., “Total Quality Management”, 4thEdition, Pearson

Education Asia, 2011. ISBN: 8131732274, 9788131732274 2. Evans, James R. and William M. Lindsay, “The Management and Control of Quality”.

6th Edition South-Western (Thomson Learning), 2005. ISBN: 0324066805, 9780324066807

Reference Books:

1. Dale, B., 2015. Total quality management. John Wiley & Sons, Ltd. ISBN: 8131732274, 9788131732274

2. Oakland, J.S; Peter Morris, “Total Quality Management: A Pictorial Guide for Managers” Routledge, 2013. ISBN: 1136017224, 9781136017223

3. Janakiraman,B and Gopal, R.K, “Total Quality Management – Text and Cases”. PHI, 2006. ISBN: 8120329953, 9788120329959

4. Suganthi,L and Anand Samuel, “Total Quality Management”, PHI, 2006. ISBN: 8120326555, 9788120326552

Assessment Pattern

CIE- Continuous Internal Evaluation: Theory (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 - - - Understand 10 - - - Apply 05 5 - 5 Analyze - 5 5 5 Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category


33

FORENSIC SCIENCE



CO1 Procure broad knowledge on the principle and practices of the different branches of forensic science in supporting court of LAW.

CO2 Understand the basic principles of Forensic science by studying the legal procedures and Ethical rules

CO3 Understand the organization of a crime Laboratory, various services provided, and duties performed by each unit and lab.

CO4 Understand the importance of different areas of forensic science with applied knowledge on crime scene reconstruction

CO5 Apply the principles and practices of various methods in the analysis different types of forensic evidence, able to use this knowledge in providing solution to forensic queries

CO6 Access and Analyse the forensic data by applying the computer forensic based methods


Module No


1

LEGAL PROCEDURES AND ETHICS: Definition, scope, history and development of Forensic science, Legal Laws, procedures and use of court. Ethical guidelines. Introduction to Crime Scene Investigation; Inquest and types, Types of Evidence and Protecting the Evidence, Witness and Dealing with Suspect Persons

9 CO1 & CO2

2

ORGANIZATION OF A CRIME LAB: Basic services provided by full service crime laboratories, Different levels of crime labs in India and their services, Physical Science unit, Biological unit, Firearms unit, Document Examination unit. Functions and duties performed by each unit and lab.

9 CO1 & CO3

3 FORENSIC BIOLOGY: Forensic Pathology: Rigor mortis, Lovor 9 CO1 & CO4

34

mortis, Algor mortis. Forensic Autopsy, Forensic Anthropology, Forensic Entomology, Forensic Psychiatry, Forensic Odontology, Foresnsic Engineering, DNA Analysis, Dactyloscopy, Fingerprints : Classification and patterns. Case studies.

4

FORENSIC ANALYSIS: Physical evidence-types, collection, forwarding to the laboratories; processing and examination. Crime Scene Photography and Sketching, Chain of custody and interpreting a Crime Scene. Biological Evidence- Characterization of blood stains, stain patterns of blood, preservation of blood evidence, characterization of semen, techniques used in toxicology, role of toxicological findings and drug recognition experts

9 CO1 & CO5

5

CYBER FORENSICS: Introduction, Storage, File System Concepts, Operating System Software and Basic Terminology, Data Recovery Procedures and Ethics, Preserve and safely handle original media, Document a "Chain of Custody", Complete time line analysis of computer files based on file creation, file modification and file access, Use computer forensics software tools to cross validate findings in computer evidence-related cases

9 CO1 & CO6

Text Books:

1. Criminalistics: An Introduction to Forensic Science by Richard Saperstein, Pearson Education Limited, Eleventh Edition, 2014, Harlow, United Kingdom. ISBN10 1292062029

2. A Hands-On Introduction to Forensic Science: Cracking the Case by Mark Okuda and Frank H. Stephenson, Apple Academic Press Inc. First Edition, 2014, Oakville, Canada. ISBN10 1482234904

Reference Books:

1. Introduction to Forensic Science and Criminalistics, by Howard Harris , Henry Lee, Taylor Francis Inc, Second Edition, 2018, Portland, United States, ISBN10 1498757960

2. Introduction to Forensic Science by Thom Jones, Createspace Independent Publishing Platform, First Edition, 2014, United States, ISBN10 1495276252

3. Introduction to Forensic Anthropology : United States Edition by Steven N. Byers, Pearson Education US, Fourth Edition, 2011, Boston, MA, United States, ISBN13 9780205790128

4. Computer forensics: evidence collection and management by Robert C. Newman and Boca Raton FL, Taylor and Francis Auerbach Publications, First Edition, 2007, ISBN 9780849305627

35

Assessment Pattern



36

INSILICO DRUG DESIGN Course Code : BTE743 Credits : 04 L: P: T: S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to: CO1 Understand the basics of Molecular modeling and drug design CO2 Understand the applications of Computer Assisted New Lead Design CO3 Apply new and emerging technologies and develop drug design Databanks

CO4 Analyze drug design through computer - Assisted Drug Discovery in various biological applications

CO5 Learn and apply Modeling Drug-Receptor Interactions in various biological applications

CO6 Design new lead for drug discovery by different approaches. Mapping of Course Outcomes to Program Outcomes: PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 CO1 2 2 2 1 2 1 1 - 1 1 1 1 CO2 2 2 2 1 2 1 1 - 1 1 1 1 CO3 2 2 2 1 2 1 1 - 1 1 1 1 CO4 2 2 2 1 2 1 1 - 1 1 1 1 CO5 2 2 2 1 2 1 1 - 1 1 1 1 CO6 2 2 2 1 3 1 1 - 1 1 1 1

Module No


1

THE MOLECULAR MODELING PERSPECTIVE IN DRUG DESIGN Definition of Molecular modeling: The first generation of rational approach in drug design, molecular modeling: the second generation, conceptual frame and methodology of molecular modeling, importance of the bioactive conformation, molecular mimicry and structural similarities, molecular mimicry, structural similarities and superimposition technique, Rational drug design and chemical intuition : an important key and the role of the molecular model list.

9 CO1

2

COMPUTER ASSISTED NEW LEAD DESIGN Introduction, Basic Concepts, Molecular Recognition by Receptor and Ligand Design, Active Conformation, Approaches to Discover New Functions, Approaches to the Cases with known and unknown receptor structure. Docking problem and Docking methods: GREEN Grid: 3-D description of binding site environment and energy calculation , automatic docking method

9 CO2

3

DATA BANKS 3-D structure database: components of a chemical database, data and source of data, queries and sources of queries, search engines, successes of 3-D database searching, In depth : the Brookhaven PDB, In Depth : The Cambridge structural Database, IUPAC conventions for peptides and nucleic

9 CO3

37

acids.

4

COMPUTER - ASSISTED DRUG DISCOVERY The Drug Development Process, Introduction, The Discovery and Development Process, New Lead Discovery Strategies, Composition of Drug Discovery Teams, The Practice of Computer- Assisted Drug Discovery (CADD), Current Practice of CADD in the pharmaceutical Industry, Management Structures of CADD Groups, Contributions and Achievements of CADD Groups, Limitations of CADD Support, Inherent Limitations of CADD Support, State of Current Computational Models, Software and Hardware Constraints.

9 CO4 CO6

5

MODELING DRUG-RECEPTOR INTERACTIONS Receptors-Introduction and Definition : Macromolecular targets, Sources of structural information, Ligand-Receptor interaction, Receptor Fitting-X ray and other explicit structures: Utility , Binding site properties, Ligand binding predictions, Free energy, Receptor mapping: The pharmacophore concept, Practical Utility, A case study in New lead Design

9 CO5 CO6

Text Books:

1. The molecular modeling perspective in drug design by N Claude Cohen, Gulf Professional Publishing, 1996, ISBN 012178245X, 9780121782450

Reference Books:

1. Bioinformatics Methods & Applications: Genomics, Proteomics & Drug Discovery, S C Rastogi, N Mendiratta & P Rastogi, PHI Learning Pvt. Ltd., 2008, ISBN 8120335953, 9788120335950.

2. An Introduction to Drug Design, S. N. Pandeya, J. R. Dimmock, New Age International, 1997, ISBN 8122409431, 9788122409437


38

MARINE BIOTECHNOLOGY

Course Code : BTE744 Credits : 04 L: P: T: S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to: CO1 Define biological oceanography, geological and geophysical systems CO2 Enlist the micro flora and isolation, culture and preservation techniques CO3 Understand the chemical, physical and biological system of marine ecosystem

CO4 Get acquainted with the knowledge of marine pharmacology and understand their Industrial applications

CO5 Understand the marine pollutants and safety measure towards the same CO6 Understand the concepts of microbes in marine ecosystem Mapping of Course Outcomes to Program Outcomes: PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 CO1 2 2 2 1 2 1 1 - 1 1 1 1 CO2 2 2 2 1 2 1 1 - 1 1 1 1 CO3 2 2 2 1 2 1 1 - 1 1 1 1 CO4 2 2 2 1 2 1 1 - 1 1 1 1 CO5 2 2 2 1 2 1 1 - 1 1 1 1 CO6 2 2 2 1 3 1 1 - 1 1 1 1

Module No


1 Biological Oceanography:

The division of the marine environment – benthing, pelagic, batuyal, littoral. Ocean waters as biological environment. Distribution and population of plants and animals. Marine ecology and fisheries potential. Effects of pollution on marine life. Geological and geophysical Oceanography: Geophysical and geological processes. Ocean basin rocks and sediments. Beach and beach processes, littoral sediment transports. Coastal erosion-causes and protection. Resources of the ocean-renewable and non-renewable.

9 CO1

2. MARINE MICROBIOLOGY Biology of micro-organisms used in genetic engineering (Escherichia coil, Rhizobium sp., Agrobacterium tumefaciens, Saccharomyces cerevisiae, phage lambda, Nostoc, Spirulina,

9 CO2

39

Aspergillus, Pencillium and Streptomyces). Methods of studying the marine micro-organisms collection, enumeration, isolation, culture & identification based on morphological, physiological and biochemical characteristics. Preservation of marine microbes, culture collection centres (ATCC, IMTECH, etc.). Microbial nutrition and nitrogen fixation. Seafood microbiology - fish & human pathogens. Indicator of Pollution - faecai coliforms - Prevention & control.

3. MARINE BIOTECHNOLOGY Physical, Chemical and Biological aspects of marine life. Air – Sea interaction – Greenhouse gases (CO2 and Methane). Marine pollution-major pollutants (heavy metal, pesticide, oil, thermal, radioactive, plastics, litter and microbial). Biological indicators and accumulators: Protein as biomarkers, Biosensors and biochips. Biodegradation and Bioremediation. Separation, purification and bioremoval of pollutants. Biofouling - Biofilm formation Antifouling and Anti boring treatments. Corrosion Process and control of marine structures. Biosafety – special characteristics of marine environment that bear on biosafety. Ethical and moral issues – food health, and environmental safety concerns.

9 CO3, CO6

4. MARINE PHARMACOLOGY Terms and definitions. Medicinal compounds from marine flora and fauna - marine toxins –antiviral, antimicrobial. Extraction of crude drugs, screening, isolation, purification and structural characterization of bioactive compounds. Formulation of drugs and Drug designing: Pharmacological evaluation – routes of drug administration – absorption, distribution, metabolism and excretion of drugs.

9 CO4

5. MARINE POLLUTION AND BIO DETERIORATION: Sources of marine pollution, its dynamics, transport paths and agents. Composition of domestic, industrial and agricultural discharges & impacts. Toxicity and treatment methods. Oil pollution: Sources, composition and its fate in marine habitats. Toxicity and treatment methods. Thermal and radioactive pollution: sources, effects and remedial measures. Solid dumping, mining and dredging operations: their effects on marine ecosystem. Role of biotechnology in marine pollution control. Biofouling and biodeterioration: Agents and protection methods. Global environmental monitoring methods: status, objectives and limitations.

9 CO5

40

TEXT BOOKS

1. Recent advances in Marine Biotechnology by Fingerman, M., Science Publishers

(2000), ISBN 13: 9781578080830.

2. Marine Biotechnology by David J.Attaway et al., Oxford & IBH Publishing (1993), ISBN

978-1-4899-2391-2.

REFERENCE BOOKS

1. Microbial ecology of the oceans by Krichman, D.L., Wiley – Liss (2000), ISBN-13: 978-

0471299929.

2. Aquaculture: The farming and husbandry and fresh and marine organisms by John E.

Bardach, John H. Ryther, William O. McLarney, Wiley lnterscience, NY (1974), ISBN:

978-0-471-04826-8

3. Molecular Ecology by Joanna R. Freeland, Stephen D. Petersen, Heather Kirk (Co-

Editor), Wiley-Blackwell, (2011), ISBN: 978-1-119-99308-7.


41

BIOSIMILARS

Course Code : BTE745 Credits : 04 L: P: T: S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Understand the basics of biosimilars CO2 Understand the process flow in synthesis of biosimilars CO3 Analyse the process flow in biosimilar biosynthesis CO4 Analyse the immunogenicity considerations for biosimilars CO5 Understand the pharmacodynamic considerations CO6 Apply and analyse regulatory affairs in biosimilar approval


PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 CO1 3 3 3 2 2 2 1 1 - - 2 3 CO2 3 3 3 2 2 2 1 1 - - 2 3 CO3 3 3 3 2 2 2 1 1 - - 2 3 CO4 3 3 3 2 2 2 1 1 - - 2 3 CO5 3 3 3 2 2 2 1 1 - - 3 3 CO6 3 3 3 2 2 2 1 1 - - 3 3

Module No


1

INTRODUCTION TO BIOSIMILARS: Definitions of biologics and biosimilars. Molecular patent of innovators expiring. Complexity of biosimilars. Approved biosimilars. Markers for biosimilars. Requirement of clinical trials. Case study: Price reduction due to introduction of biosimilars

9 CO1

2

PROCESS FLOW OF MAKING BIOSIMILARS: Concept of expression system. Host cells available for expression of proteins or biosimilars. Mammalian cell lines and microbial cells. Post translational modification- Glycosylation (Generalised Process Flow Chart).Bioreactors consideration in biosimilar synthesis. Downstream process: Affinity Chromatography, Ion Exchange Chromatography, HIC, TFF, DF

9 CO2

3

LIGAND BINDING ASSAYS AND VALIDATION: Bioequivalence consideration. Ligand binding assays. ELISA and other immunoassay. Radiolabels (RIA & IRMA). Luminescence (MSD). Ligand Binding Assay Issues. Analytical aspects. Analytical Characteristics to evaluate in pre-validation and final validation. Dilution linearity. Ligand binding assays to support PK and TK of biologics. LC-MS Methodology (MS.MS, TOF, Quadrupole, Ion Trap, Electrospray) Immunoaffinity-Capture Based LC-MS.MS. Applications to validate biomarkers.

9 CO3 CO4

42

Common issues that complicate Biomarker Development. Therapeutic equivalence evaluation

4

IMMUNOGENICITY CONSIDERATIONS OF BIOSIMILARS:Facto influencing immunogenicity. Structural factors. Primary structure Glycosylation. Pegylation. Secondary and tertiary structures. Impuritie and other production contaminants. Manufacturing process an formulation of the medicinal product. Patient and subsequen treatment factors. Case of monoclonal antibodies

9 CO3 CO4

5

PHARMACOKINETICS AND REGULATORY AFFAIRS REGARDING BIOSIMILARS: PK/PD Modelling and Simulation Biomarkers and Clinical End Points in PK-PD Modelling. Model-based Drug Development. Regulations overviewing the approval of biosimilars. FDA, ICH, CDSO guidelines. Case study of PEG-GCSF rejection by FDA. Case study related to Approved Biosimilars.

9 CO5 CO6

TEXT BOOKS:

1. Biosimilars: A New Generation of Biologics 2012th Edition by Jean-Louis Prugnaud (Editor),‎ Jean-Hugues Trouvin. ISBN: 2817803353

2. Biosimilars: Design and Analysis of Follow-on Biologics Shein-Chung Chow. ISBN

9781466579699 REFERENCE BOOKS:

1. Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics. Lisa M.Plitnick and DanutaJ. Herzyk .ISBN: 978-0-12-394810-6

2. Biosimilars and Interchangeable Biologics: Tactical Elements. Sarfaraz K. Niazi ISBN 9781498743495

CIE- Continuous Internal Evaluation: Theory (50 Marks)


Remember 05 - 2 - Understand 05 5 2 5 Apply 10 5 1 5 Analyze 05 - - - Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category


https://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&text=Jean-Louis+Prugnaud&search-alias=books&field-author=Jean-Louis+Prugnaud&sort=relevancerank

https://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&text=Jean-Hugues+Trouvin&search-alias=books&field-author=Jean-Hugues+Trouvin&sort=relevancerank

43

GENOME INFORMATICS Course Code : BTE746 Credits : 04 L: P: T: S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Know the basics of whole genome, exome and targeted re-sequencing CO2 Understand the fundamentals of and applications of transcriptome re-sequencing CO3 Apply the knowledge of small rna sequence analytics. CO4 Analyze and make use of transcriptome assembly CO5 Learn and apply metagenome analytics to evaluate genomics problems CO6 Create big data of genome and analyze the same for multiple applications


PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 CO1 2 2 1 2 3 1 2 - 2 1 2 1 CO2 2 2 1 2 3 1 2 - 2 1 2 1 CO3 2 2 1 2 3 1 2 - 2 1 2 1 CO4 2 2 1 2 3 1 2 - 2 1 2 1 CO5 2 2 1 2 3 1 2 - 2 1 2 1 CO6 2 2 1 2 3 1 2 - 2 1 2 1

Modul No


1

WHOLE GENOME, EXOME AND TARGETED RE-SEQUENCING Introduction to genome Re-Sequencing, Indexing the reference genome, Sequence Alignment Tools and its Parameters, Alignment quality Assessment, Exome Enrichment Analysis, Target /Non-Target Enrichment Analysis, Statistical Analysis and genome Visualization, Introduction to Variation Analysis, Variation analysis to identify SNV / MNV / SV, dbSNP Annotation / Variation Effect Prediction, Variation Frequency Analysis, Exome Copy Number Variation Analysis, Data Visualization, Function & Structure based Comparative Genome Analysis

9 CO1

2

TRANSCRIPTOME RE-SEQUENCING Introduction to RNA-Seq Sequencing Alignment, Indexing the reference genome, Alignment Tools and its Parameters, Aligning Single End / Paired End reads to the indexed genome, Alignment quality Assessment, Statistical Analysis and genome Visualization, Qualitative & Quantitative Gene Expression Profiling, Gene Modifications & Alternative Splicing Analysis, Gene Fusion identification, Differential Gene Expression Profiling, Gene Ontology and Pathway Analysis

9

CO2

3 SMALL RNA SEQUENCE ANALYTICS 9 CO3

44

Introduction to small-RNA Sequencing, Qualitative assessment of Known SmallRNA Transcripts, Known miRNA Expression Profiling, Novel miRNA Identification & Expression Profiling, Known & Novel siRNA (Phased / Unphased) Identification, Differential Expression Profiling of Known & Novel small RNAs, Small RNA (miRNA / siRNA) Target Prediction & Annotation, Gene Ontology and Pathway Analysis of Predicted Targets, Analysis summary & reporting

CO6

4

TRANSCRIPTOME ASSEMBLY Introduction to Transcriptome De-novo Sequencing, Assembly Tools & Parameters, Transcriptome Clustering and Assembly Evaluation, Qualitative & Quantitative Analysis of Assembled Transcriptome, SSR Marker Identification & Analysis, Differential Gene Expression Profiling (For Multiple Samples), Gene Ontology and Pathway Analysis;

9 CO4 CO6

5

METAGENOME ANALYTICS Introduction to Metagenome Sequencing and experimental designs, Understanding various analytics tools & parameters, Singleton removal & De-replication, Clustering & Chimera filtering, OTU identification, OTU annotation and functional classification, OTU abundance estimation & comparative biology, Refraction curve and Statistical analysis

9 CO5 CO6

TEXTBOOK:

1. Ali Masoudi-Nejad, Zahra Narimani, Nazanin Hosseinkhan; “Next Generation Sequencing and Sequence Assembly”, Methodologies and Algorithms, Springer; 2013, ISBN 1461477263, 9781461477266.

2. Wu, Wei, Choudhry, Hani (Eds.), “Next Generation Sequencing in Cancer Research: Volume 1: Decoding the Cancer Genome”, Springer, 2013, ISBN 1461476453, 9781461476450

REFERENCE BOOKS:

1. Mark I. Rees, “Challenges and Opportunities of Next-generation Sequencing for Biomedical Research”, Academic Press, 2012, ISBN 0123982731, 9780123982735

Assessment Pattern CIE- Continuous Internal Evaluation (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 2 2 5 Understand 10 1 2 3 Apply 5 2 1 2 Analyze - - - - Evaluate - - - - Create - - - - SEE- Semester End Examination (50 Marks) Bloom’s Category Tests Marks(Out of 50)

45

Remember 20 Understand 20 Apply 10 Analyze - Evaluate - Create -

46

PROFESSIONAL ELECTIVE – V

BIOETHICS & BIOSAFETY

Course Code : BTE751 Credits : 04 L:P:T:S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50

Course outcomes: At the end of the course, the students will be able to

CO1 Understand the various principles of Ethics and Bioethics CO2 Analyze the Laboratory safety measures to be followed in industry CO3 Evaluate various regulations employed in Biotechnology CO4 Analyze the various ecological and safety measures applied in industry CO5 Understand about bio ethical and biosafety assessment of Agri and Pharma

industry CO6 Evaluate various Case studies based on Bioethical Principles

Mapping of Course Outcomes to Program Outcomes

PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12

CO1 3 3 3 2 2 2 1 3 1 1 2 3 CO2 3 3 3 2 2 2 1 3 1 1 2 3 CO3 3 3 3 2 2 2 1 3 1 1 2 3 CO4 3 3 3 2 2 2 1 3 1 1 2 3 CO5 3 3 3 2 2 2 1 3 1 1 3 3 CO6 3 3 3 2 2 2 1 3 1 1 3 3

Module No


1 BIOETHICS Principles of bioethics: Legality, morality and ethics, autonomy, human rights, beneficence, privacy, justice, equity etc. The expanding scope of ethics from biomedical practice to biotechnology, bioethics vs. business ethics, ethical dimensions of IPR, technology transfer and other global biotech issues.

9 CO1

2 BIOSAFETY IN THE LABORATORY Laboratory associated infections and other hazards, assessment of biological hazards and levels of biosafety, prudent biosafety practices in the laboratory/ institution. Experimental protocol approvals, levels of containment.

9 CO2

REGULATIONS Biosafety assessment procedures in India and abroad. International dimensions in biosafety, bioterrorism and

9

CO3

47

3

convention on biological weapons. Social and ethical implications of biological weapons. Biosafety regulations and national and international guidelines with regard to recombinant DNA technology. Guidelines for research in transgenic plants. Good manufacturing practice and Good lab practices (GMP and GLP). National and international regulations for food and pharma products.

4

ECOLOGICAL & FOOD SAFETY The GM-food debate and biosafety assessment procedures for biotech foods & related products, including transgenic food crops, case studies of relevance. Key to the environmentally responsible use of biotechnology. Environmental aspects of biotech applications. Use of genetically modified organisms and their release in environment.

9 CO4

5

AGRI & PHARMA SECTOR Discussions on recombinant organisms and transgenic crops, with case studies of relevance. Plant breeder’s rights. Legal implications, Biodiversity and farmers rights. Biosafety assessment of pharmaceutical products such as drugs/vaccines etc. Biosafety issues in Clinical Trials.

9 CO5

Text Books:

1. Biotechnology and Safety Assessment by Thomas, J.A., Fuch, R.L, Elsevier, 2002.ISBN 9780080528182

2. IPR, Biosafety and Bioethics by DeepaGoel, Shomini Parashar Published by Pearson Education (2013)ISBN 9788131774700

Reference Books

1. Bioethics &Biosaftey by Sateesh Mk, IK Publishers,2008ISBN 9788190675703 2. Biosafety Management by P.L. Traynor, Agricultural Biotechnology Support Project,

Institute of International Agriculture, Michigan State University, 2002. ISBN 9781565250161

3. Bioethics by Ben Mepham, Oxford University Press, 2008 ISBN 9780199214303 4. Biotechnology and Intellectual Property Rights: Legal and Social Implications by K K

Singh Springer, 2014 ISBN 9788132220596

Assessment Pattern

CIE- Continuous Internal Evaluation (50 Marks)

Bloom’s Taxonomy

Tests (25 Marks)

Assignments (10 Marks)

Quizzes (5 Marks)

SSA (10 Marks)

Remember 10 - 2 - Understand 10 - 2 5 Apply 5 5 1 5 Analyze - 5 - -

48

Evaluate - - - - Create - - - - SEE- Semester End Examination (50 Marks)

Bloom’s Taxonomy Test Marks out of 50 Remember 20 Understand 10 Apply 10 Analyze 05 Evaluate 05

METABOLIC ENGINEERING Course Code :BTE752 Credits : 04 L: P: T: S :3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Understand the basics of metabolic engineering and basics of metabolites CO2 Understand different steps in metabolic pathways and its regulation CO3 Analyse the material energy balance and their requirements CO4 Construct metabolic flux analysis matrix and their interpretations CO5 Understand the metabolic design analysis CO6 Analyse the metabolic design analysis through successful case studies



Module No


1

Introduction to metabolic engineering: Historical perspective and introduction; Importance of metabolic engineering; Paradigm shift; Information resources; Scope and future of metabolic engineering; Building blocks of cellular components; Polymeric biomolecules; Protein structure and function; Biological information storage – DNA and RNA

9 CO1

49

2

Review of cellular metabolism: Transport mechanisms and their models; Enzyme kinetics; Mechanisms and their dynamic representation; Regulation of enzyme activity versus regulation of enzyme concentration; Regulation of metabolic networks; Regulation of at the whole cell level; Example of important pathways; Case studies and analytical type problem.

9 CO2

3

Material and Energy Balances:Stoichiometric models and matrix representation; the chemical reaction vector and energetic; Material and energy balances revisited; Basis for simplification of reaction; Elemental balances Component balances and the link with macroscopic measurements; Examples of construction of elemental and component balances.

9 CO3 CO4

4

Metabolic Flux Analysis and control theory:The theory of flux balances; Derivation of the fundamental principle; Degree of freedom and solution methods; Moore-Penrose inverse and Tsai-lee matrix construction; Examples of applications of flux analysis introduction Metabolic Control Theory; Control coefficients; Elasticity Coefficients; Summation and connectivity theorems; Case Studies and examples.

9 CO3 CO4

5

Metabolic design: Gene amplification, Genedisruption, Randomized and targeted strain development. Metabolic Engineering in Practice: Actual examples from research and industrial biotechnology.Metabolic Engineering Practice The concept of metabolic pathway synthesis; Need for pathways synthesis, Examples for illustration; Overall perspective of MFA, MCA and MPA and their application; Three success case studies.

9 CO5 CO6

TEXT BOOKS: 1. Metabolic Engineering – Principles and Methodologies by Gregory N. Stephanopoulos,

Aristos A. Aristides, Jens Nielsen, Elsevier. ISBN: 978-0-12-666260-3

2. P.F. Stanbury and A. Whitkar Principle of Fermentation Technology, Pergammon press. ISBN: 0-08-024406-8

3. Control of metabolic process by A.C. Bowden and M.L. Cardens, Plenum Publisher. ISBN 978-1-4757-9856-2

REFERENCE BOOKS: 1. Bioprocess Engineering basic concepts by M.L. Shuler and Kargi. Second Edition. ISBN-

13: 978-0130819086 2. PHI Fermentation and enzyme Technology by Wang D I C Cooney C I and Demain, A L,

John Willey. ISBN13 9780471919452 3. Metabolism of Agrochemicals in Plants by T. Roberts,Willey Int. Biochemistry by Zubey.

G, McMillan publications ISBN: 9780471801504 4. Scaleup Methods in Chemical Engineering by Johnson and Thrins. ISBN-10: 0070326932

50

Assessment Pattern CIE- Continuous Internal Evaluation: Theory (50 Marks)


Remember 05 - 2 - Understand 05 - 2 5 Apply 10 - 1 5 Analyze 05 - - Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category Tests Marks(Out of 50) Remember 10 Understand 10 Apply 20 Analyze 10 Evaluate - Create -

51

DAIRY BIOTECHNOLOGY

Course Code :BTE753 Credits : 04 L:P:T:S :3:0:0:1 CIE Marks : 50 Exam Hours :03 SEE Marks : 50 Course outcomes: At the end of the course, the students will be able to CO1 Understand about the functional role of Dairy Industry and its application CO2 Understand the applications of Biotechnology in Dairy Industry CO3 Analyze the various engineering aspects applied in Dairy Processing CO4 Understand the various approaches used in the design of a Dairy plant CO5 Analyze the various Quality and safety measures to be implemented in Dairy

Product manufacturing CO6 Evaluate the Quality measures in Dairy Plant Industries



Module No


1 DAIRY INDUSTRY Overview of dairy industry, Characteristics of dairy Industry. Manufacturing & processing of dairy products, effect of processing on constituents and methods of evaluation of dairy products.

9

1

2 DAIRY BIOTECHNOLOGY Genetic engineering of bacteria and animals intended for dairy-based products: DNA cloning. protoplast fusion & cell culture methods for trait improvement with instances cited. Enzymes in dairy industry & production by whole cell immobilization. Biotechnology of dairy effluent treatment. Ethical issues relating to genetic modification of dairy microbes & milk-yielding animals.

9

2

3

DAIRY ENGINEERING Sanitization: Materials and sanitary features of the dairy equipment. Sanitary pipes and fittings, standard glass piping, plastic tubing, fittings and gaskets, installation, care and maintenance of pipes & fittings. Description and maintenance of can washers, bottle washers.

9

3

52

Homogenization: Classification, single stage and two stage homogenizer pumps, power requirements, care and maintenance of homogenizers, aseptic homogenizers. Pasteurization: Batch, flash and continuous (HTST) pasteurizers, Flow diversion valve, Pasteurizer control, Care and maintenance of pasteurizers. Filling Operation: Principles and working of different types of bottle filters and capping machine, pouch filling machine (Pre-pack and aseptic filling bulk handling system, care and maintenance.

4

DAIRY PLANT DESIGN AND LAYOUT Introduction of Dairy Plant design and layout. Type of dairies, perishable nature of milk, reception flexibility. Classification of dairy plants, selection of site for location. General points of considerations for designing dairy plant, floor plant types of layouts, service accommodation, single or multilevel design. Arrangement of different sections in dairy, Arrangement of equipment, milk piping, material handling in dairies. Drains and drain layout for small and large dairies. Ventilation, fly control, mold prevention, illumination in dairy plants.

9

4

5

QUALITY AND SAFETY MONITORING IN DAIRY INDUSTRY Current awareness on quality and safety of dairy foods; consumer awareness and their demands for safe foods; role of Codex Alimentations Commission (CAC) in harmonization of international standards; quality (ISO 9001:2000) and food safety (HACCP) system and their application during milk production and processing. National and international food regulatory standards; BIS, PFA, ICMSF, IDF etc., their role in the formulation of standards for controlling the quality and safety of dairy foods. Good Hygiene Practices (GHP). Quality of water and environmental hygiene in dairy plant; treatment and disposal of waste water and effluents

9

5

Text Books:

1. Diary Science & Technology Handbook, Edited by Hui, Y.H, Wiley, 2006,ISBN 9780470127063

2. Diary Microbiology Handbook, Edited by Robinson, R.K., John Wiley & Sons, 2005,ISBN 9780471227564

Reference Books

1. General Microbiology, Powar&Daginawala, Himalaya Publishers,2005 2. Milk composition, production & biotechnology (Biotechnology in Agriculture Series

18)-CAB International, 1997,ISBN 9780851991610 3. Handbook of Farm, Dairy & Food Machinery by Myer Kutz, William Andrew,

2007,ISBN9780815517511

53

4. Comprehensive Biotechnology, Edited by N.C Gautam, Shree Publications

Assessment Pattern


Bloom’s Taxonomy

Tests (25 Marks)


Quizzes (5 Marks)

SSA (10 Marks)

Remember 10 - 2 - Understand 10 - 2 5 Apply 5 5 1 5 Analyze - 5 - - Evaluate - - - - Create - - - -

SEE- Semester End Examination (50 Marks)


54

HOSPITAL SAFETY AND MANAGEMENT Course Code : BTE754 Credits : 04 L: P: T: S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Understand the general evolution and history of health care system CO2 Analyse the requisite in the organization of OPD CO3 Understand and evaluate the Organization of Ancillary Services CO4 Apply the management skills in Dietary Services management in a Hospital CO5 Apply the management skills in financial management CO6 Evaluate the concept of financial and budgeting skills in health services



Module No


1

EVOLUTION OF HEALTH CARE SYSTEMS: Introduction, Medicine in Ancient Times, Primitive Medicine, Indian Medicine, Chinese Medicine, Hospital Management, Responsibilities Of The Hospital Administrator, Hospital Design, Hospital Engineering, Hospital Hygiene

9 CO1

2

Organization of Out – Patient Services:Objectives and Scope of O.P. Services, The Services Offered in the O.P.D.Location of OPD Services, Advantages of Separate O.P.D, Disadvantages of Separate O.P.D, Physical Infra Structure and Facilities in O.P.D, Physical Infra Structure and Facilities in O.P.D, Problems Encountered in Functioning of Outpatient Department, Complaints Regarding the Quality of Service, In-Patient Services. Ward Management, Organization of Casualty and Emergency Services.

9 CO2

3

Organization of Ancillary Services: Laboratory Services, Diagnostic Laboratories, Staffing of the Laboratory Services, Technicians Laboratory Assistants Administrative Staff Auxillary Staff Record System, Organization of Department of Physiotherapy and Occupational Therapy, Organization of the Department of Radiodiagnosis

9 CO3 CO4

55

4

Organization and Management of Dietary Services in a Hospital: Space Requirements for a Dietary Service. Staff Requirements. Functions of Dietician and other Staff. General Food services. Clinical functions. Dietary Stores Management. Supply of Orders. Quality Control. Housekeeping and Maintenance Services. Medical Records. Staffing the Hospital. Physiotherapists and Occupational Therapists

9 CO3 CO4

5

FINANCING HEALTH SERVICES – RESOURCE MOBILIZATION: Financial Resources of Hospitals, Role of Department Head, Health Financing System, Budgeting, Categories of Expenditure, Management assisted by computers: Reservation, Admission, Registration and Discharge Module. Hospital Management System Module Admission, Registration and Discharge, Continuation of Hospital Management System Module, Human Resource Management System.General Requirements for Maintenance

9 CO5 CO6

TEXT BOOKS:

1. Hospital Management: Text & Cases, 1e Paperback – 2013by Ramani.ISBN-10: 8131794016

2. Hospitals - Facilities Planning & Management – 1 Jul 2017 G. D Kunders ISBN-13: 978-0070502697

REFERENCE BOOKS: 1. How to Set up a Hospital Along with SOPs – 2016 Dr. Arun K. Agarwal.ISBN-13: 978-

8126920952 2. Principles Of Hospital Administration And Planning Paperback – 2009 Sakharkar .ISBN-

13: 978-818448632 3. Financial Management Hospital Administration Paperback – 2009 by Kulkarni.ISBN-

13: 978-8184486247

CIE- Continuous Internal Evaluation: Theory (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10

Remember 05 - 2 5 Understand 05 5 2 5 Apply 10 5 1 - Analyze 05 - - - Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category Tests Marks(Out of 50) Remember 10 Understand 10 Apply 20 Analyze 10 Evaluate - Create -

https://www.amazon.in/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=Ramani&search-alias=stripbooks

https://www.amazon.in/G.-D-Kunders/e/B001JG8Y98/ref=dp_byline_cont_book_1

https://www.amazon.in/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=Dr.+Arun+K.+Agarwal&search-alias=stripbooks

https://www.amazon.in/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=Sakharkar&search-alias=stripbooks

https://www.amazon.in/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=Kulkarni&search-alias=stripbooks

56

SYSTEMS BIOLOGY

Course Code :BTE755 Credits : 04 L:P:T:S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course outcomes: At the end of the course, the students will be able to

CO1 Understand the Fundamentals ,concepts and principles of System Biology CO2 Understand the kinetics in Biological system CO3 Study about the developmental aspects of system biology CO4 Study about gene expression networks emphasizing the transcription networks CO5 Learn about the practical applications of system biology based on sophisticated

technology available currently CO6 Analyze in detail about the biological networks and its applications in system

biology


PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 CO1 3 2 2 2 2 2 2 2 1 2 2 1 CO2 3 2 2 2 2 2 2 2 1 2 2 1 CO3 3 2 2 2 2 2 2 2 1 2 2 1 CO4 3 2 2 2 2 2 2 2 1 2 2 1 CO5 3 2 2 2 2 2 2 2 1 2 2 1 CO6 3 2 2 2 2 2 2 2 1 2 2 1 Module No


1 Systems Biology – Fundamentals Concepts and working principles of System Biology Overview of Gene Control –Working of Genetic Switches – Introductory Systems Biology The biochemical paradigm, genetic paradigm and the systems paradigm.

9

CO1

2 Kinetics Equilibrium Binding and Co-operativity -Michaelis-Menten Kinetics –identical and independent binding sites – Identical and interacting binding sites, non-interacting binding sites. Genetic switch in Lambda Phage -Noise-based Switches and Amplifiers for Gene Expression. Synthetic genetic switches –Ecolichemotaxis –biological oscillators- genetic oscillators -The Origin and Consequences of Noise in Biochemical Systems.

9

CO2

3

Developmental Systems Biology Building an Organism Starting From a Single Cell -Quorum Sensing – Programmed Population Control by Cell-Cell Communication and Regulated Killing- Drosophila Development.

57

Establishment of Developmental Precision and Proportions in the Early Drosophila embryo.

9 CO 3

4

Gene expression networks Gene regulation at a single cell level- Transcription Networks -basic concepts -coherent Feed Forward Loop (FFL) and delay gate -The incoherent FFL -Temporal order, Signaling networks and neuron circuits -Aspects of multi-stability in gene networks.

9

CO4,CO6

5

Practical applications of System Biology in Life Sciences - Introduction to System Biology platforms Proprietary system Biology platform. Microarray data analysis - Microarray analysis platforms - Introduction to Concepts and principles of Microarray technology - Application of Microarrays in Life Sciences,Different Markup languages used in systems biology. Introduction to NGS technology.

9

CO 5

Text Books:

1. Networks: An Introduction by M.E.J. Newman, Oxford University Press, 2010.ISBN9780191500701

2. Introduction to Systems Biology: Design Principles of Biological Circuits by Uri Alon, Chapman & Hall/CRC, 2007. ISBN 9781584886426

Reference Books

1. Introduction to Systems Biology, S. Choi, Springer Science & Business Media, 2008.ISBN 9781597455312

2. Linked – The New Science of Networks, Albert-LászlóBarabási, Hachette UK, 2014,ISBN 9780465038619

3. Evolutionary Dynamics: Exploring the Equations of Life by Nowak, M. A Belknap Press, 2006ISBN 9780674023383

4. Gregory Stephanopoulos IsidoreRigoutsos :Systems Biology ,Oxford University Press, USA, 2007 ISBN 9780195300819

Assessment Pattern


Bloom’s Taxonomy

Tests (25 Marks)


Quizzes (5 Marks)

SSA (10 Marks)


58



59

BIOMEDICAL ENGINEERING

Course Code : BTE 756 Credits : 04 L:P:T:S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course outcomes: At the end of the course, the students will be able to

CO1 Understand and acquire an overview of all Biological Principles CO2 Understand about membrane potential and the electrical properties of

membranes CO3 Analyze the electrical activity of major organs and its importance CO4 Analyze about various biochemical transducers and its applications CO5 Understand about various Biological Sensors and it use in Biomedical field CO6 Evaluate and apply the knowledge based on current trends in Biomedical

Engineering field



Module No


1 Biological principles: Composition & properties of the cell membrane, membrane transports, permeability Coefficient & partition coefficient, body fluids, electrolytes, acid-base balance, blood viscosity and Newtonian nature, colloids, filtration, diffusion, osmosis, dialysis, ultrafiltration, ultracentrifugation, cellular fractionation, electrophoresis, plasmapherosis, radioimmunoassay.

9

CO1

2 Bioelectricity: Membrane Potential, Local and propagator types, Diffusion potential, phase boundary potentials, Generator Potentials, compound Action Potentials (AP), Propagation of AP, factors influencing propagation of AP, biosignal and types, Electrical properties of excitable membranes, Membrane Capacitance, Resistance, conductance, dielectric properties of membrane.

9

CO2

Electrical stimulus & Biophysical activity: Stimuli, Receptor potential, pacemaker potential, strength duration relationship, skin impedance, total body impedance, impedances at high frequencies, patient safety, electrical

9

CO3

60

3 shock and hazards, leakage current, Electrical activity of brain (EEG), different wave forms & their characteristics, Electrical activity of heart (ECG), waveform and significance.

4

Biochemical Transducers: Electrode theory: electrode-tissue interface, metal-electrolyte interface, electrode-skin interface, electrode impedance, Biopotential electrodes: microelectrodes, body surface electrodes, needle electrodes, electrodes for ECG, EEG, and EMG. Reference electrodes: hydrogen electrodes, silver-silver chloride electrodes, Calomel electrodes, Ion electrodes: specific ion electrodes, pH electrode, O2 electrode, CO2 electrode.

9

CO4

5

Biological sensors: Sensors / receptors in the human body, basic organization of nervous system-neural mechanism, Chemoreceptor: hot and cold receptors, barro receptors, sensors for smell, sound, vision, Ion exchange membrane electrodes, enzyme electrode, glucose sensors, immunosensors, Basic principles of MOSFET biosensors & BIOMEMS, basic idea about Smart sensors.

9

CO5

Text Books:

1. The Biomedical Engineering Hand Book- 3rd Ed- (Biomedical Engineering Fundamentals) - Joseph D. Bronzino – CRC –Tylor-Francis – 2006 (Section- III – Bio-Electrical Phenomena)ISBN0849321247, 9780849321245

2. Rao&Guha,”Principles of Medical Electronics & Biomedical Instrumentation”, University Press,2013 India ISBN 9788173712579.

Reference Books:

1. R. S. Khandpur, “Handbook of Biomedical Instrumentation”, Tata McGraw Hill.2003,ISBN 9780070473553

2. S.C. Cobbold, “Transducers for Biomedcial Instruments”, Wiley 2008ISBN 9780471161455

3. Brown & Gann, “Engineering Principles in Physiology Vol. I”, Academic Press. 4. Carr & Brown, Introduction to Biomedical Equipment Technology Prentice Hall 2001

ISBN8177588834

Assessment Pattern


Bloom’s Taxonomy Tests (25 Marks)


Quizzes (5 Marks)

SSA (10 Marks)


61



62

GLOBAL ELECTIVE - II

IPR AND BIO-ENTREPRENEURSHIP



CO1 Procure knowledge on the principles and application of IPR in biotechnology industry and apply this knowledge to become Bio entrepreneur.

CO2 Study basic principles of Patent laws and understand the Patent filing types, methods and the process of filling patent.

CO3 Know the importance of patenting of biotech innovation and aware about the moral issues in patenting BT invention

CO4 Get equipped with the essential knowledge on Traditional resources of India and their protection policies and stratergies

CO5 Understand the entrepreneurial process and its different phases and equip with the knowledge on the essential tools to become an entrepreneur

CO6 Develops awareness on various opportunities for networking and community building among Entrepreneurs and advocate the importance of innovations in technology and its role as an economic driver


Module No


1

INTELLECTUAL PROPERTY AND PATENTS: Introduction, Constitutional aspects of Intellectual property and different types. Patent filing types and methods. Basic principles of Patent laws: Historical background in UK, US and India. Basis for IP protection. Criteria for patentability: Novelty, Utility, and Inventive step, Non obviousness, Non patentable invention. tent Search and Assessment

9 CO1 & CO2

2 PATENT LAWS & BT: Objectives, Evolution and Application of Biotechnology, Commercial potential of BT invention, R & D investments, Rationale and applications. Concept of Novelty

9 CO1 & CO3

63

and Inventive step in BT, Micro organisms and BT inventions, Moral issues in patenting BT invention. Substantiation of Patent laws & international agreements related to pharma, microbial, environmental, agricultural and informatics sectors via classical case studies.

3

TRADITIONAL KNOWLEDGE: Concept of Traditional knowledge, stake holders, Justification for geographical indication. Plant variety protection in India. International position, UPOV 1991 guidelines, issues concerning traditional knowledge, Bioprospecting & Biopyracy – ways to tackle, Protectability of traditional knowledge under existing IP framework, need for sui-generis regime, Traditional knowledge on the International arena, Traditional knowledge at WTO and National level, Traditional knowledge digital library.

9 CO1 & CO4

4

BIOENTREPRENEURSHIP: Terminology and introduction, development and progression of entrepreneurial Concept, Functional roles of Entrepreneur, Types of Entrepreneur, Intrapreneur–an emerging Class, Development of Entrepreneurship steps in entrepreneurial process, Role of entrepreneurs in Economic Development: Entrepreneurship in India, Challenges to woman and achievements of woman Entrepreneurs, Identification of Business Opportunities

9 CO1 & CO5

5

INDUSTRY STARTUPS & BUSINESS PLAN: Industry types, Meaning of Industry startups, Nature of Support; Objectives, and rationale, Scope of small scale industries (SSI) in India, role of SSI in Economic Development, Advantages of SSI, Steps to start SSI – Government policy towards SSI, Functions, Types of Help, Different model of Biotechnology based strat-ups, Turn an idea into a business plan/start-up (Successful case studies). Preparation of business plan of our choice, Identification of venture capitalist. TOT, managing the transition from a small entrepreneurial firm to a large, sustainable Industry

9 CO1 & CO6

Text Books: 1. Biotechnology and Intellectual Property Rights: Legal and Social Implications,

by Kshitij Kumar Singh (Author), Springer; 2015 edition, ISBN 978-81-322-2059-6 2. Biotechnology Entrepreneurship: Starting, Managing, and Leading Biotech

Companies Edited by Craig Shimasak, Academic Press, First Edition, 2014, eBook ISBN: 9780124047471

Reference Books:

1. Intellectual Property Rights in Biotechnology Worldwide by Bent, Stephen A, Richard L. Schwaab, David G. Conlin, Donald D. Jeffery, Palgrave Macmillan UK, First Edition, 1987, ISBN 978-1-349-08009-0, DOI- 10.1007/978-1-349-08009-0

64

2. Biodiversity, Biotechnology And Traditional Knowledge, Edited by Aravind Kumar, Govind Das, Narosa publishing house, first edition, 2010, ISBN: 978-81-8487-097-8

3. Intellectual Property Rights in the WTO and developing contry by Watal Jayashree, Oxford University Press, First Edition, 2001. ISBN 10: 0195661702 ISBN 13: 9780195661705

4. Intellectual Property and Criminal Law by Gopalakrishnan, N S, Bangalore: National Law School of India University.

Assessment Pattern

CIE- Continuous Internal Evaluation: Theory (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 - - - Understand 10 - - - Apply 05 5 - 5 Analyze - 5 5 5 Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category Tests Marks (out of 50) Remember 15 Understand 15 Apply 10 Analyze 10 Evaluate - Create -

65

BIOMASS AND BIOFUELS Course Code : BTE762 Credits : 04 L:P:T:S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Understanding of various renewable feedstocks of importance, and their availability and attributes for biofuels production.

CO2 Develop Knowledge about second and third generation biofuel production from biomass and other low-cost agri-residues and bio-wastes.

CO3 Get acquainted with tools and knowledge necessary for biofuel facility operations. CO4 Apply and design processes for biofuel production. CO5 To teach Nanotechnology applications in bioenergy fields.

CO6 Apply concept to improvise existing processes to state of art technologies to get higher yield of biofuel production



Module No


1

ENERGY Introduction; Resources: Renewable and non-renewable resources (Water, Minerals, and Energy; Use and overexploitation; Classification and Sources of Energy; Problems relating demand and supply of various energy sources; Coal, Petroleum etc. Current scenario in world wide and India.

9

CO1 CO2

2

BIOMASS & ENERGY CROPS Energy Crops: Wood (Lignocellulose) – Degradation by microorganisms and pathway studies. Sugar and Starch crops - Degradation by microorganisms and pathway studies. Oil seeds crops - Degradation by microorganisms and pathway studies.Hydrocarbon producing crops - Degradation by microorganisms and pathway studies.

9

CO1 CO2 CO3

66

3

BIOFUELS First Generation Biofuels: Bioethanol , – Production meachnisms by microbes, Second Generation Biofuels: Methane and Hydrogen – Production mechanisms by microbes, Factors affecting Biogas yields. Third Generation Biofuels : Biobutanol. Biodesel from algae.

9 CO4,CO5

4

CLEAN COAL TECHNOLOGY Principles of Microbial Metal Leaching: Leaching Mechanisms: Models of Leaching Mechanisms. Factors Influencing Bioleaching. Bacterial Attachment on Mineral Surfaces Microbial Diversity in Bioleaching Environments. Case Studies of Bioleaching Applications: Commercial-Scale Copper Ore Bioleaching; Bacterial oxidation of Chalcophyire and pyrite; Reactor Bioleaching of Fly Ash; Shake Flask Bioleaching of Electronic Scrap; Bioremediation of Metal-Contaminated Sites.

9 CO1,CO2 CO5

5

SPECIAL TOPICS From Microbes to Megawatts – Microbial Fuel Cells - Types of Biological fuel cells – Working Principle - Applications of Biological Fuel cells. Biofilm - Theory and Applications.Biosensor - Theory and Applications. Environmental Nanobiotechnology: Nano carbons, Nano catalysts, Nano aerosols & gels for waste water treatment.

9 CO1,CO5 CO6

Text Books:

1. Samir K. Khanal, “Anaerobic Biotechnology for Bioenergy Production: Principles and Applications”, Wiley-Blackwell Publishing, ISBN: 978-0-813-82346-1,2008

2. David M. Mousdale, “Biofuels: Biotechnology, Chemistry, and Sustainable Development “CRC Press, ISBN 9781420051247 - CAT# 51245 ,2008.

Reference books:

1. Robert C. Brown, “Biorenewable Resources: Engineering New Products from Agriculture”, Wiley-Blackwell Publishing, ISBN :978-1-118-52495-4,2003.

2. Pogaku, Ravindra; Sarbatly, Rosalam Hj. (Eds.), “Advances in Biofuels”, Springer, ISBN: 978-1-4614-6249-1, 2013.

3. Gupta, Vijai Kumar; Tuohy, Maria G. (Eds.), “Biofuel Technologies Recent Developments”, Springer, ISBN 978-3-642-34519-7, 2013

4. Bioenergy: Biomass to Biofuels 1st Edition, Anju Dahiya, Academic Press, ISBN-13: 978-0124079090,2014

https://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&text=Anju+Dahiya&search-alias=books&field-author=Anju+Dahiya&sort=relevancerank

67

Assessment Pattern CIE- Continuous Internal Evaluation (50 Marks)


Remember 10 5 2 - Understand 10 3 2 5 Apply 5 2 1 5 Analyze - - - - Evaluate - - - - Create - - - - SEE- Semester End Examination (50 Marks) Bloom’s Category

Tests Marks(Out of 50) Remember 20 Understand 20 Apply 10 Analyze - Evaluate - Create -

68

BIOMATERIALS Course Code :BTE763 Credits : 04 L: P: T: S : 3:0:0:1 CIE Marks : 50 Exam Hours : 03 SEE Marks : 50 Course Outcomes: At the end of the Course, the Student will be able to:

CO1 Understand the basics of Biomaterials CO2 Understand the concepts of Metals & Ceramics CO3 Know the basics and applications of Synthetic & Biopolymers CO4 Learn and apply Cardiovascular Biomaterials in various biological applications CO5 Analyze and evaluate Biocompatibility in various biological applications CO6 Create new biomaterial by learning the concepts of synthesis


Module No


1

INTRODUCTION Introduction, Historical developments, construction materials, impact of biomaterials, strength of biological tissues, performance of implants, tissue response to implants, interfacial phenomena, safety and efficacy testing. Structure and Properties of Materials: Atomic and molecular bonds, crystal structure of solids, phase changes, crystal imperfections, non-crystalline solids, surface properties, mechanical properties of materials, thermal treatments, surface improvements, sterilization.

9 CO1

2

METALS & CERAMICS Introduction, Stainless steels, Cobalt-Chromium alloys, Titanium based alloys, Nitinol, other metals, metallic Corrosion, biological tolerance of implant metals, Carbons, Alumina, Yttria stabilized zirconia, surface reactive ceramics, resorbable ceramics, composites, analysis of ceramic surfaces.

9

CO2 CO6

3

SYNTHETIC & BIOPOLYMERS Polymers in biomedical use, polyethylene and polypropylene, perfluorinated polymers, acrylic polymers, hydrogels, polyurethanes, polyamides, biodegradable synthetic polymers, silicone rubber, plasma polymerization, micro-organisms in polymeric implants, polymer sterilization. polymers as biomaterials, heparin and heparin-like polysaccharides, proteoglycans, structure and biological activities of

9 CO3 CO6

69

native sulfated glycosaminoglycans, chemically modified glycosaminoglycans.

4

CARDIOVASCULAR BIOMATERIALS Tissue properties of blood vessels, Treatments of atherosclerosis; Biomechanical design issues pertaining to stents, balloon angioplasty, and pacemakers. Soft Tissue Reconstruction; Natural and Synthetic. Wound healing. Tissue ingrowths: Stability; Biofixation, Foreign Body response, Soft implants. Case Studies. Tissue Engineering: Current issues and Future Directions.

9 CO4 CO6

5

BIOCOMPATIBILITY Definition, Wound healing process-bone healing, tendon healing. Material response: Function and Degradation of materials in vivo. Host response: Tissue response to biomaterials, Effects of wear particles. Testing of implants: Methods of test for biological performance- In vitro implant tests, In vivo implant test methods. Qualification of implant materials.

9 CO5

Text Books:

1. Biomaterials Science : An Introduction to materials in medicine by Buddy D Ratner. Academic Press, 2012, ISBN 008087780X, 9780080877808.

2. Polymeric Biomaterials by Severian Dumitriu, CRC Press, 2013, ISBN 1420094688, 9781420094688

Reference Books:

1. Biological Performance of materials by Jonathan Black, Marcel Decker, CRC Press, 2005,ISBN 0849339596, 9780849339592.

2. Polymeric Biomaterials by Piskin and A S Hoffmann, Martinus Nijhoff, VSP, 1995, ISBN 9067641804, 9789067641807.

3. Biomaterials by Lawrence Stark & GyanAgarwal, Springer Science & Business Media, 2012, ISBN 1461565553, 9781461565550.

4. Biomaterials by Sujata V. Bhat, Springer Science & Business Media, 2012, ISBN 9401003289, 9789401003285

Assessment Pattern CIE- Continuous Internal Evaluation (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 4 2 - Understand 10 2 2 5 Apply 5 4 1 5 Analyze - - - - Evaluate - - - - Create - - - -

70

SEE- Semester End Examination (50 Marks) Bloom’s Category Tests Marks(Out of 50) Remember 20 Understand 15 Apply 15 Analyze - Evaluate - Create -

71

MINI PROJECT

Course Code : BTE77 Credits: 02 L:P:T:S : 0:2:0:0 CIE Marks: 25 Exam Hours : 3 SEE Marks: 25 The student shall be enabled to identifying a problem related to the field of Biotechnology and carry out a mini project on the problem defined. Each student is expected to do the mini project individually or in a group of maximum three students. The outcomes of the project will be reviewed by a panel of experts during the course of the semester. Plagiarized projects will automatically get an “F” GRADE and the student will be liable for further disciplinary action. Upon the completion of a project the student will submit a project report, which will be evaluated by duly appointed examiner(s).

CIE - Continuous Internal Evaluation (25 Marks)

Bloom’s Taxonomy Mini Project Remember - Understand - Apply 10 Analyze 10 Evaluate 5 Create - SEE – Semester End Examination (25marks) Bloom’s Taxonomy Mini Project Remember - Understand - Apply 10 Analyze 10 Evaluate 5 Create -

72

EIGHTH SEMESTER

(Syllabus)

73

GLOBAL ELECTIVE - III

RENEWABLE ENERGY SOURCES


Course Outcomes: At the end of the Course, the Student will be able to

CO1 Gain knowledge about the importance of renewable energy resources, especially in Indian context

CO2 Understand the features of solar thermal energy and its applications CO3 Understand the benefits of Hydrogen energy and wind energy

CO4 Understand and apply the concepts of wealth from waste with reference to waste management

CO5 Define Biomass, Biogas and understand its applications

CO6 Understand the hydral energy systems – sea and ocean; and their advantages and disadvantages


Module No


1

Introduction: Causes of Energy Scarcity, Solution to Energy Scarcity, Factors Affecting Energy Resource Development, Energy Resources and Classification, Renewable Energy – Worldwide Renewable Energy Availability, Renewable Energy in India.

9 CO1

2

Solar Thermal Energy Collectors: Types of Solar Collectors, Configurations of Certain Practical Solar Thermal Collectors, Material Aspects of Solar Collectors, Concentrating Collectors, Applications of Solar Water Heating Systems, Active Solar Space Cooling, Solar Air Heating, Solar Dryers, Crop Drying, Space Cooing, Solar Cookers, Solar pond. Solar Cells: Components of Solar Cell System, Elements of Silicon Solar Cell, Solar Cell materials, Practical Solar Cells, I – V Characteristics of Solar Cells, Efficiency of Solar Cells,

9 CO1 CO2

74

Photovoltaic Panels, Applications of Solar Cell Systems

3

Hydrogen Energy: Benefits of Hydrogen Energy, Hydrogen Production Technologies, Hydrogen Energy Storage, Use of Hydrogen Energy, Advantages and Disadvantages of Hydrogen Energy, Problems Associated with Hydrogen Energy. Wind Energy: Windmills, Wind Turbines, Wind Resources, Wind Turbine Site Selection. Solid waste and Agricultural Refuse: Waste is Wealth, Key Issues, Waste Recovery Management Scheme, Advantages and Disadvantages of Waste Recycling, Sources and Types of Waste, Recycling of Plastics

9 CO1 CO3

4

Biomass Energy: Biomass Production, Energy Plantation, Biomass Gasification, Theory of Gasification, Gasifier and Their Classifications, Chemistry of Reaction Process in Gasification, Applications of Biomass Gasifier, Cooling and Cleaning of Gasifiers. Biogas Energy: Introduction, Biogas and its Composition, Anaerobic Digestion, Biogas Production, Benefits of Biogas, Factors Affecting the Selection of a Particular Model of a Biogas Plant, Biogas Plant Feeds and their Characteristics.

9 CO1 CO4 CO5

5

Sea Wave Energy: Introduction, Motion in the sea Waves, Power Associated with Sea Waves, Wave Energy Availability, Devices for Harnessing Wave Energy, Advantages and Disadvantages of Wave Power. Ocean Thermal Energy: Introduction, Principles of Ocean Thermal Energy Conversion (OTEC), Ocean Thermal Energy Conversion plants, Basic Rankine Cycle and its Working, Closed Cycle, Open Cycle and Hybrid Cycle, Carnot Cycle, Application of OTEC in Addition to Produce Electricity, Advantages, Disadvantages and Benefits of OTEC

9 CO1 CO6

Text Books:

1. Tiwari, G.N. and Mishra, R.K., 2015. Advanced renewable energy sources. Royal Society of Chemistry. ISBN: 178262578X, 9781782625780

2. Kothari, D.P., Singal, K.C. and Ranjan, R., 2011. Renewable energy sources and emerging technologies. PHI Learning Pvt. Ltd.. ISBN: 8120344707, 9788120344709

Reference Books:

1. Johansson, T.B. and Burnham, L. eds., 1993. Renewable energy: sources for fuels and electricity. Island press.ISBN: 1559631384, 9781559631389

2. Letcher, T.M., 2016. Storing energy: with special reference to renewable energy sources. Elsevier. ISBN: 0128034491, 9780128034491

3. Maczulak, A.E., 2009. Renewable energy: sources and methods. Infobase Publishing. ISBN: 0816072035, 9780816072033

4. Abbasi, T. and Abbasi, S.A., 2011. Renewable energy sources: their impact on global warming and pollution. PHI Learning Pvt. Ltd. ISBN: 8120339940, 9788120339941

75

Assessment Pattern



76

NUTRACUETICALS AND FUNCTIONAL FOOD


Course Outcomes: At the end of the Course, the Student will be able to

CO1 Understand the basic concepts of Nutracueticals and functional food, their chemical nature and methods of extraction

CO2 Understand the role of Nutracueticals and functional food in health and disease CO3 Define Phytochemicals and differentiate the methods of their analysis

CO4 Define antioxidants and recollect the methods of assessing the antioxidant activities in foods

CO5 Identify the role of Neutraceuticals in health and diseases and further would be able apply it real time scenarios

CO6 Understand the safety issues, health claims and the associated regulations for Neutraceuticals


Module No


1

INTRODUCTION AND SIGNIFICANCE Introduction to Nutracueticals and functional foods; importance, history, definition, classification, list of functional foods and their benefits, Phytochemicals, zoo chemicals and microbes in food, plants, animals and microbes

9 CO1

2

ANALYSIS OF PHYTOCHEMICALS Qualitative and quantitative methods: phytoestrogens in plants; isoflavones; flavonols, polyphenols, tannins, saponins, lignans, Chitin; Carotenoids - Factors affecting bioavailability, chemical and histochemical characterization of cell wall polysaccharides in almond seed in relation to lipid bioavailability.

9 CO3

3 ASSESSMENT OF ANTIOXIDANT ACTIVITY In vitro and In vivo methods for the assessment of antioxidant activity, Comparison of different In Vitro methods

9 CO4

77

to evaluate the antioxidant, Prediction of the antioxidant activity of natural phenolics from electro topological state indices, Optimizing Phytochemical release by process technology; Variation of Antioxidant Activity during technological treatments, new food grade peptidases from plant sources

4

ROLE IN HEALTH AND DISEASE Nutracueticals and Functional foods in Gastrointestinal disorder, Cancer, CVD, Diabetic Mellitus, HIV and Dental disease; Importance and function of probiotic, prebiotic and symbiotic and their applications, Functional foods and immune competence; role and use in obesity and nervous system disorders.

9 CO2 CO5

5 SAFETY ISSUES Health Claims, regulations and safety issues- International and national scenarios.

9 CO6

Text Books:

1. Wildman, Robert “Handbook of Nutracueticals and Functional Foods”. CRC Press, 2016. ISBN: 1420006185, 9781420006186

2. Geoffrey Webb. “Dietary Supplements and Functional Foods”. John Wiley & Sons, 2011. ISBN: 1444340077, 9781444340075

3. Shi, John, Fereidoon Shahidi and Chi-Tang Ho “Asian Functional Foods”. CRC/Taylor & Francis, 2005. ISBN: 1420028111, 9781420028119

4. Bagchi, D., Preuss, H.G. and Swaroop, A. eds., 2015. Nutraceuticals and functional foods in human health and disease prevention. CRC Press. ISBN: 1482237229, 9781482237221

Reference Books:

1. Bagchi, D., Lau, F.C. and Ghosh, D.K. eds., 2010. Biotechnology in functional foods and nutraceuticals. CRC Press. ISBN: 1420087126, 9781420087123

2. Jayaprakasha, G.K. and Patil, B.S. eds., 2015. Nutraceuticals and Functional Foods:: Chemistry And Health Promoting Properties Of Fruits And Beverages Involved In Prevention Of Chronic Diseases. EOLSS Publications. ISBN: 178021037X, 9781780210377

Assessment Pattern

CIE- Continuous Internal Evaluation: Theory (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 - - - Understand 10 - - - Apply 05 5 - 5 Analyze - 5 5 5

78

Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category


79

MEDICAL ELECTRONICS


Course Outcomes: At the end of the Course, the Student will be able to CO1 Define medical electronics and understand overview of electrodes and signals CO2 Understand the different types of transducers used CO3 Enlist the monitoring systems used in medical electronics CO4 Identify the safety issues concerned with the usage of medical instruments CO5 Know the broad spectrum applications of the medical imaging CO6 Understand the Applications of monitoring system in various fields Mapping of Course Outcomes to Program Outcomes: PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 CO1 3 2 3 1 1 1 1 3 2 2 3 2 CO2 3 2 3 1 1 1 1 3 2 2 3 2 CO3 3 2 3 1 1 1 1 3 2 2 3 2 CO4 3 2 3 1 1 1 1 3 2 2 3 2 CO5 3 2 3 1 1 1 1 3 2 2 3 2 CO6 3 2 3 1 1 1 1 3 2 2 3 2

Module No.

Module Content Hours CO’s

1. Overview of Medical Electronics Equipments, classification, application and specifications of diagnostic, therapeutic and clinical laboratory equipment, method of operation of these instruments, Bioelectric signals, Bio electrodes, Electrode tissue interface, contact impedance, Types of Electrodes, Electrodes used for ECG, EEG

9 CO1

2. Transducers Typical signals from physiological parameters, pressure transducer, flow transducer, temperature transducer, pulse sensor, respiration sensor

9 CO2

3. Patient Monitoring Systems ECG Machine, EEG Machine, EMG Machine, Heart rate measurement, Pulse rate measurement, Respiration rate measurement, Blood pressure measurement, Principle of defibrillator and pace mark, Use of Microprocessor in patient monitoring.

9 CO3, CO6

4. Safety Aspects of Medical Instruments Physiological effects of electricity, Physiological effects of current, Electricity grid, Consequences of dangerous voltage, Safe voltages – AC & DC, Ventricular fibrillation,

9 CO4

80

Microshock vs. macroshock, Protective grounding, Power in clinical environments, Leakage currents, Regulations, standards and recommendations

5. Clinical applications of medical imaging Abdominal Imaging in Clinical Applications, An Overview of Pectoral Muscle Extraction Algorithms Applied to Digital Mammograms, Magnetic Resonance Brain Imaging Segmentation Based on Cascaded Fractional-Order Darwinian Particle Swarm Optimization and Mean Shift Clustering, 3D Brain Tumor Segmentation Based on Hybrid Clustering Techniques Using Multi-views of MRI

9 CO5

Text Books:

1. Handbook of biomedical Instrumentation by RS Khandpur, McGraw Hill Education; Third edition (2014), ISBN-13: 978-9339205430

2. Biomedical Instrumentation by Cromwell, Prentice Hall India Learning Private Limited; 2 edition (1990), ISBN-13: 978-8120306530

Reference Books:

1. Modern Electronics Equipment by RS Khandpur, TMMH, New Delhi, McGraw-Hill Higher Education (1 December 1987), ISBN-13: 978-0074517161

2. Introduction to BioMedical Electronics by Edward J. Perkstein; Howard Bj, USA, Glencoe/McGraw-Hill School Pub Co (January 1, 1978), ISBN-13: 978-0070178953

Assessment Pattern

CIE- Continuous Internal Evaluation: Theory (50 Marks) Bloom’s Category Tests Assignments Quizzes SSA Marks (out of 50) 25 10 5 10 Remember 10 - - - Understand 10 5 - 5 Apply 05 5 5 5 Analyze - - - - Evaluate - - - - Create - - - - SEE- Semester End Examination: Theory (50 Marks) Bloom’s Category Tests Marks (out of 50) Remember 15 Understand 15 Apply 10 Analyze 10 Evaluate - Create -

81

PROJECT WORK

Course Code : BTE82 Credits: 20 L:P:T:S : 0:20:0:0 CIE Marks: 275 Exam : Viva-Voce SEE Marks: 275 The student shall be enabled to identifying a problem related to the field of Biotechnology and allied areas to carry out a project work on the problem defined. Each student is expected to do the project work individually or in a group of maximum three students. The outcomes of the project will be reviewed by a panel of experts during the course of the semester. Plagiarized projects will automatically get an “F” GRADE and the students will be liable for further disciplinary action. Upon the completion of a project the students will submit a project report and face a viva-voce, which will be evaluated by duly appointed examiner(s). The different phases in which the project work would be evaluated include, Phase I:

• Review of Literature, Writing of abstract and review paper. Phase II:

• Technical Seminar on the project work – projecting novelty / applicability assessment and societal relevance.

Phase III: • Identification of Lacunae, Framing Objectives.

Phase IV: • Experimental Design.

Sub Phase V: • Result Analysis, Thesis Preparation and Viva.

CIE - Continuous Internal Evaluation (275 Marks)

Bloom’s Taxonomy Project Work Remember - Understand 25 Apply 100 Analyze 100 Evaluate 50 Create - SEE – Semester End Examination (275marks) Bloom’s Taxonomy Project Work Remember - Understand 25 Apply 100 Analyze 100 Evaluate 50 Create -

82

APPENDIX A

Outcome Based Education

Outcome-based education (OBE) is an educational theory that bases each part of an educational system around goals (outcomes). By the end of the educational experience each student should have achieved the goal. There is no specified style of teaching or assessment in OBE; instead classes, opportunities, and assessments should all help students achieve the specified outcomes.

There are three educational Outcomes as defined by the National Board of Accredition:

Program Educational Objectives: The Educational objectives of an engineering degree program are the statements that describe the expected achievements of graduate in their career and also in particular what the graduates are expected to perform and achieve during the first few years after graduation. [nbaindia.org]

Program Outcomes: What the student would demonstrate upon graduation. Graduate attributes are separately listed in Appendix C

Course Outcome: The specific outcome/s of each course/subject that is a part of the program curriculum. Each subject/course is expected to have a set of Course Outcomes

Mapping of Outcomes

83

APPENDIX B The Graduate Attributes of NBA

Engineering knowledge: Apply the knowledge of mathematics, science, engineering fundamentals, and an engineering specialisation to the solution of complex engineering problems. Problem analysis: Identify, formulate, research literature, and analyse complex engineering problems reaching substantiated conclusions using first principles of mathematics, natural sciences, and engineering sciences. Design/development of solutions: Design solutions for complex engineering problems and design system components or processes that meet the specified needs with appropriate consideration for the public health and safety, and the cultural, societal, and environmental considerations. Conduct investigations of complex problems: The problems that cannot be solved by straightforward application of knowledge, theories and techniques applicable to the engineering discipline that may not have a unique solution. For example, a design problem can be solved in many ways and lead to multiple possible solutions that require consideration of appropriate constraints/requirements not explicitly given in the problem statement (like: cost, power requirement, durability, product life, etc.) which need to be defined (modeled) within appropriate mathematical framework that often require use of modern computational concepts and tools. Modern tool usage: Create, select, and apply appropriate techniques, resources, and modern engineering and IT tools including prediction and modelling to complex engineering activities with an understanding of the limitations. The engineer and society: Apply reasoning informed by the contextual knowledge to assess societal, health, safety, legal, and cultural issues and the consequent responsibilities relevant to the professional engineering practice. Environment and sustainability: Understand the impact of the professional engineering solutions in societal and environmental contexts, and demonstrate the knowledge of, and need for sustainable development. Ethics: Apply ethical principles and commit to professional ethics and responsibilities and norms of the engineering practice. Individual and team work: Function effectively as an individual, and as a member or leader in diverse teams, and in multidisciplinary settings. Communication: Communicate effectively on complex engineering activities with the engineering community and with society at large, such as, being able to comprehend and write effective reports and design documentation, make effective presentations, and give and receive clear instructions. Project management and finance: Demonstrate knowledge and understanding of the engineering and management principles and apply these to one’s own work, as a member and leader in a team, to manage projects and in multidisciplinary environments. Life-long learning: Recognise the need for, and have the preparation and ability to engage in independent and life-long learning in the broadest context of technological change.

84

APPENDIX C

BLOOM’S TAXONOMY

Bloom’s taxonomy is a classification system used to define and distinguish different levels of human cognition—i.e., thinking, learning, and understanding. Educators have typically used Bloom’s taxonomy to inform or guide the development of assessments (tests and other evaluations of student learning), curriculum (units, lessons, projects, and other learning activities), and instructional methods such as questioning strategies. [eduglosarry.org]

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