dennis a. velez, md cerebrovascular/endovascular neurosurgery dept. of neurological surgery...
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Dennis A. Velez, MDCerebrovascular/Endovascular Neurosurgery
Dept. of Neurological SurgeryVanderbilt University
ObjectivesTo recognize cerebral vasospasm (CVS) as a
treatable complication of aSAHTo safely and effectively institute optimal
medical management of CVSTo recognize the different modalities used to
diagnose CVSTo learn to identify which patients may
benefit from endovascular therapy for CVS
DefinitionCVS has been defined in various ways: Clinical vasospasm (delayed cerebral
ischemia, DCI)Angiographic vasospasmTCD vasospasmWhich one is more clinically relevant?
PathophysiologyProlonged arterial contraction: oxyhemoglobinStructural changes in the arterial wall: arterial
hyperplasia, platelet aggregation and edema-luminal narrowing, increased resistance, decreased blood flow
Breakdown of blood products: oxyhemoglobin, serotonin, prostaglandins, catecholamines, histamine, angiotensin
Inflammatory response: neurogenic and classic inflammation
Histological changes
Role of Hgb oxidation products
Intracellular signaling
Inflammatory Response
CVS Prediction: Patient-specific factors
Clinical gradeBlood volume and frequency of SAHSize and location of aneurysm(s)Cocaine useSexAgeSmokingHypertension
Glasgow Coma Scale
Hunt and Hess Grading Scale
WFNS Grading Scale
Fisher Scale
Pathological MarkersEndothelin 1LeukocytosisSoluble adhesion moleculesLipid peroxidesCellular proliferation and Growth FactorsHypomagnesemiaGenetic markers
Diagnostic Neurological ImagingDSA/Conventional angiographyCT angiography/CT perfusionTCDSPECTDWI/PWI
TCD
CVS Treatment OptionsTriple “H” therapyAlbumin 5%/Normal SalinePressorsHemodilutionNimodipineStatinsLumbar drainage/ Head shakingEndovascular treatment: IA/TBAIntra-aortic balloon counterpulsation (IABC)
Lumbar Drainage
Head Shaking for CVS
Intra-aortic balloon counterpulsation