DENDRITIC CELLS INFUNDAMENTAL ANDCLINICAL IMMUNOLOGY

Eduard W. A. Kamperdijk

Paul Nieuwenhuis

Elisabeth C. M. Hoefsmit

Advances in experimental medicine and biology; v. 329)

General Introduction 1Dendritic cells : Antigen presentation, accessory function and clinical relevance

Ralph M. Steinman, Margit Witmer-Pack, and Kayo Inaba

CELLULAR AND MOLECULAR BIOLOGY OF ANTIGEN PRESENTATIO N

Endocytic activity of dendritic cells is similar to other antigen presenting cells . . 1 1Timothy P . Levine and Benjamin M . Chain

Immunocytochemical characterization of dendritic cells

1 7Joanne M.S . Arkema, Inge L. Schadee-Eestermans, Donna M . Broekhuis -Fluitsma and Elisabeth C .M. Hoefsmi t

Requirements of exogenous protein antigens for presentation to CD4 + Tlymphocytes by MHC Class II-positive APC 23

Gernot Gradehandt, Johannes Hampl, Nadja Kleber, Christina Lobron, SilkeMilbradt, Burkhard Schmidt, and Erwin Riide

Modulation of MHC Class II determinants on rat Langerhans cells during shor tterm culture 29

Ursula Neili, Detlef Becker, Jürgen Knop, and Konrad Reske

A dendritic cell specific determinant present in endosomes is involved in th epresentation of protein antigens 3 5

Toshiyuki Maruyama, Elisabeth C .M. Hoefsmit and Georg Kraa l

Dendritic cells are potent antigen-presenting cells for microbial superantigen

. . . 41Sharifah Iqball, Reshma Bhatt, Penelope Bedford, Peter Borriello an dStella Knigh t

Divergent T-cell cytokine profiles induced by dendritic cells from different tissues 4 7Michael P . Everson, William J . Koopman and Kenneth W . Beagley

Adhesion molecules : Co-stimulators and Co-mitogens in dendritic cell - T cel linteraction 53

Philip D. King, Mohammad A.A. Ibrahim and David R . Katz

Dendritic cell dependent expression of IgA by clones in T1B microcultures . . . . 59

Carol E . Schrader and John J. Cebra

Adhesion molecules in tonsil DC-T cell interactions

65

Derek N .J . Hart and Timothy C .R. Prickett

Dendritic cells have reduced cell surface membrane glycoproteins including CD4 3determinants 7 1

William Egner, Barry D. Hock, and Derek N .J . Hart

The effect of human dendritic cells on the lectin-induced responsiveness o fCD4 +T cells to IL-2 and IL-4 7 5

Sergiusz Markowicz and Anita Meht a

Analysis of cytokine and cytokine receptor production by human dendritic cells . . 8 1Victoria L . Calder, Timothy C .R. Prickett, Judith L . McKenzie and

Derek N .J . Hart

Costimulating factors and signals relevant for antigen presenting cell function . . . 87Marc K. Jenkins, Dimuthu R . DeSilva, Julia G. Johnson, and Steven D . Norton

ANTIGEN PRESENTING CELLS IN T CELL REGULATION AND REPERTOI-RE SELECTIO N

Distinct T cell stimulation mechanism and phenotype of human blood dendriti ccells 9 3

Hui Xu, Ulrike Friedrichs, Robert K .H. Gieseler, Jörg Ruppert, Göran Ocklind ,and J .Hinrich Peters

The role of dendritic cells in the regulation of T cell cytokine synthesis 99Joanna Ellis, Mohammad A . A. Ibrahim, Benjamin M. Chain, and David R. Katz

The role of dendritic cells as co-stimulators in tolerance induction

105Michal Dabrowski, Mohammad A .A. Ibrahim, Benjamin M. Chain and

David R. Katz

The influence of dendritic cells on T-cell cytokine production

11 1Erna van Wilsem, John Breve, Ingrid van Hoogstraten, Huub Savelkoul an d

Georg Kraal

Phenotypical and functional characterization of dendritic cells in the huma nperitoneal cavity 117

Michiel G .H. Betjes, Cees W. Tuk, and Robert H.J . Beele n

Dendritic cells isolated from rat and human non-lymphoid tissue are verypotent accessory cells 12 3

Robert H.J . Beelen, Ellen van Vugt, Joke J .E. Steenbergen, MichielG .H. Betjes, Chan E.G. Havenith and Eduard W .A. Kamperdijk

Antigen presenting capacity of peritoneal macrophages and dendritic cells . . .

12 9Ellen van Vugt, Marina A .M . Verdaasdonk, Eduard W.A. Kamperdijk, an d

Robert H.J . Beelen

T-cell repertoire development in MHC class II deficient humans

13 5Marja van Eggermond, Marijke Lambert, Francoise Mascart, Etienn eDupont and Peter van den Elle n

Rat thymic dendritic cells

14 1Ed. W.A . Kamperdijk, Joanne M .S . Arkema, Marina A .M. Verdaasdonk ,

Robert H.J . Beelen and Ellen van Vug t

Rat thymic dendritic Cells : flow cytometry analysis

14 7Maria Purificacion Bafiuls, Alberto Alvarez, Isabel Ferrero, Agustin Zapata

and Carlos Ardavi n

Ultrastructure of interdigitating cells in the rat thymus during Cyclospori nA treatment 15 3

Eric J . de Waal, Louk H .P.M. Rademakers, Henk-Jan Schuurman andHenk van Loveren

T cell tolerance and antigen presenting cell function in the thymus

159David J . Izon, John D . Nieland, Lori A . Jones and Ada M . Kruisbeek

DENDRITIC CELLS : IN VITRO PHENOTYPE AND FUNCTIO N

Tolerizing mice to human leukocytes : A step toward the production ofmonoclonal antibodies specific for human dendritic cells 16 5

Una O'Doherty, William J . Swiggard, Kayo Inaba, Yasunori Yamaguchi ,Iris Kopeloff, Nina Bhardwaj, and Ralph M . Steinman

Morphological and functional differences between HLA-Dr + peripheral blooddendritic cells and HLA Dr +IFN-alpha producing cells 17 3

Stuart E . Starr, Santu Bandyopodhyay, Vedapuri Shanmugam, Nassef Hassan ,Steven Douglas, Stephanie J . Jackson, Giorgio Trinchieri an dJihed Chehimi

Three monoclonal antibodies to antigen presenting cells in the rat withdifferential influence on cellular interactions 17 9

Jan Damoiseaux, Ed Döpp, Marina Verdaasdonk, Ed Kamperdijk an dChristine Dijkstr a

The MHC expression of dendritic cells from mouse spleen isolated by centrifuga lelutriation is upregulated during short term culture 185

Miriam A . Ossevoort, Ren6 E.M. Toes, Marloes L .H. De Bruijn, Corneli sJ .M. Melief, Carl G . Figdor and W . Martin Kast

I1-6 and its high affinity receptor during differentiation of monocytes int oLangerhans cells 19 1

Gertrud Rossi, Markus Schmitt, Martin Owsianowski, Bernhard Thiele, an dHarald Gollnick

Phagocytosis of antigens by Langerhans cells

199Caetano Reis e Sousa and Jonathan M. Austyn

Dissection of human Langerhans cell allostimulatory function . Modulation b y

interferon-y 205

J . Peguet-Navarro, C . Dalbiez-Gauthier, C . Dezutter-Dambuyant and

D. Schmit t

Human in vitro T cell sensitization using hapten-modified epidermal Langerhan scells 209

Corinne Moulon, Josette Peguet-Navarro, Pascal Courtellemont ,Gerard Redziniak and Daniel Schmitt

Monocyte-derived Langerhans cells from different species - morphological an dfunctional characterization 213

Falko Steinbach and Bernhard Thiel e

A serial section study of mice Langerhans cell granules after DNFB painting . . 21 9Akira Senoo, Nobuo Imazeki, Yoshifusa Matsuura and Yusuke Fus e

Skin dendritic cell-lymphocyte interactions in autologous system

22 5Hanna Galkowska and Waldemar L. Olszewski

Induction of the low affinity receptor for IgE (FcERII/CD23) on human bloo ddendritic cells by interleukin-4 23 1

Susanne Krauss, Elfriede Mayer, Gerti Rank and E .Peter Rieber

Fc ERI mediates IGE-binding to human epidermal Langerhans cells

237Oliver Kilgus, Binghe Wang, Armin Rieger, Birgit Osterhoff, Kenichi Ochiai ,

Dieter Maurer, Dagmar Födinger, Jean-Pierre Kinet and Georg Stingl

Murine epidermal Langerhans cells as a model to study tissue dendritic cells . . 243Gerold Schuler, Franz Koch, Christine Heufler, Eckhardt Kämpgen ,

Gerda Topar, and Nikolaus Romani

DENDRITIC CELLS IN VIVO: PHENOTYPE AND FUNCTIO N

Differentiation of dendritic cells in cultures of rat and mouse bone marrow cells

25 1William E. Bowers, Shengqiang Yu, and Syeedur Khandka r

TNF and GM-CSF dependent growth of an early progenitor of dendriti cLangerhans cells in human bone marrow 257

Cecil D.L. Reid, Arthur Stackpoole and Jaak Tikerpa e

Human bone marrow contains potent stimulatory cells for the allogeneic ML Rwith the phenotype of dendritic cells 263

William Egner, Judith L . McKenzie, Stewart M. Smith, Michael E .J . Beard ,and Derek N.J . Hart

Recombinant GM-CSF induces in vitro differentiation of dendritic cells fro mmouse bone marrow 269

Christoph Scheicher, Maria Mehlig, Reinhard Zecher, Friedrich Seiler,Petra Hintz-Obertreis and Konrad Reske

Signals required for differentiating dendritic cells from human monocytes in vitro 27 5J . Hinrich Peters, Hui Xu, Jörg Ruppert, Dorothea Ostermeier, Detlef

Friedrichs, Robert K .H. Gieseler

Down-regulation and release of CD 14 on human monocytes by IL-4 depends o nthe presence of serum or GM-CSF 28 1

Jörg Ruppert, Christiane Schutt, Dorothea Ostermeier and J .Hinrich Peters

Serum-free differentiation of rat and human dendritic cells, accompanied b yacquisition of the nuclear lamins A/C as differentiation markers 287

Robert K.H. Gieseler, Hui Xu, Rolf Schlemminger and J .Hinrich Peters

Immunophenotypic and ultrastructural differentiation and maturation o fnonlymphoid dendritic cells in osteopetrotic (op) mice with the tota labsence of macrophage colony stimulating factor activity 293

Kiyoshi Takahashi, Makoto Naito, Yuki Morioka and Leonard D . Shultz

Loading of dendritic cells with antigen in vitro or in vivo by immunotargetingcan replace the need for adjuvant 29 9

T. Sornasse, V . Flamand, G . De Becker, K. Thielemans, J . Urbain, O . Leo andM. Moser

Migration of alveolar macrophages from alveolar space to paracortical T cel larea of the draining lymph node 30 5

Theo Thepen, Eric Claassen, Karin Hoeben, John Breve and Georg Kraa l

Comparison of Langerhans cells and interdigitating reticulum cells

31 1Mikihiro Shamoto, Satoru Hosokawa, Masanori Shinzato and Chiyuki Kanek o

Migration of dendritic cells during contact sensitization

31 5S. Hill, S . Griffiths, I. Kimber and S .C. Knigh t

Peritoneal cell labelling : A study on the migration of macrophages anddendritic cells towards the gut 32 1

Marsetyawan Soesatyo, Theo Thepen, Muhammad Ghufron ,Jeike Biewenga, and Taede Sminia

Dendritic Cells "in vivo" : Migration and antigen handling

32 7G. Gordon MacPherson and Liming Liu

FOLLICULAR DENDRITIC CELLS : PHYSIOLOGY AND PATHOLOG Y

Follicular dendritic cells : Isolation procedures, short and long term cultures . . . 333Ernst Heinen, Rikyia Tsunoda, Christian Marcoty, Nadine Antoine, Alai n

Bosseloir, Nadine Cormann and Leon Simar

Heterogeneity and cellular origin of follicular dendritic cells

33 9Yutaka Imai, Kunihiko Maeda, Mitsunori Yamakawa, Yasuaki Karube ,

Mikio Matsuda, Michio Dobashi, Hironobu Sato and Kazuo Terashima

Differential uptake and trapping of TI-2 antigens : An unexpected role forfollicular dendritic cells in the induction of TI-2 immune responses . . . . 345

A.J .M . Van den Eertwegh, M .M. Schellekens, W .J .A. Boersma an d

E. Claassen

Ultrastructural heterogeneity of follicular dendritic cells in the human tonsil . . . 353

Louk H.P .M. Rademakers and Henk-Jan Schuurman

Ultrastructural analysis of human lymph node follicles after HIV-1 infection . . . 359Louk H.P .M . Rademakers, Henk-Jan Schuurman and Jack F . de Frankrijke r

Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro . . . 365Rikiya Tsunoda, Masayuki Nakayama, Ernst Heinen, Katsuya Miyake ,

Kazunori Suzuki, Hirooki Okamura, Naonori Sugai and Mizu Kojim a

The localization of lymphokines in murine germinal centers

37 1T . Kasajima, A. Andoh, Y. Takeo and T . Nishikawa

Two different mechanisms of immune-complex trapping in the mouse splee nduring immune responses 37 7

Kikuyoshi Yoshida, Timo K . van den Berg and Christine D. Dijkstra

Cellular requirements for functional reconstitution of follicular dendritic cell sin SCID mice 38 3

Zoher F . Kapasi, Gregory F . Burton, Leonard D. Shultz, John G . Tew andAndras K .Szakal

Interaction through the LFA-I/ICAM-1 pathway prevents programmed cel ldeath of germinal center B cells 38 7

Gerrit Koopman, Robert M .J . Keehnen and Steven T . Pal s

Membrane expression of Fce RII/CD23 and release of soluble CD23 b yfollicular dendritic cells 393

E. Peter Rieber, Gerti Rank, Ingrid Köhler and Susanne Krauss

Follicular dendritic cells in malignant lymphomas - Distribution, phenotypes &ultrastructures 399

Kunihiko Maeda, Mikio Matsuda, Masaru Narabayashi, Ryuichi Nagashia ,Noriyuki Degawa and Yutaka Imai

Lymphoid follicles in Cynomolgus monkeys after infection with simia nimmunodeficiency virus 405

Piet Joling, Peter Biberfeld, Henk K. Parmentier, Dick F . van Wichen ,Timo Meerloo, Louk H.P.M. Rademakers, Jiirg Tschopp, Jaap Goudsmit ,and Henk-Jan Schuurman

Destruction of follicular dendritic cells in murine acquired immunodeficienc ysyndrome (MAIDS) 41 1

Akihiro Masuda, Gregory F. Burton, Bruse A . Fuchs, Andras K . Szakal an dJohn G. Tew

Changes in follicular dendritic cell and CD8+ cell function in macaque lymp hnodes following infection with SIV 251 41 7

Yvonne J . Rosenberg, Marie H . Kosco, Mark G . Lewis, Enrique C . Leon ,Jack J . Greenhouse, Kyle E . Bieg, Gerald A. Eddy, and Philip M . Zack

Rapid and selective isolation of follicular dendritic cells by low spee dcentrifugations on discontinuous BSA gradients 42 5

Christian Marcoty, Ernst Heinen, Nadine Antoine, Rikiya Tsunoda an dL.J . Simar

Follicular dendritic cells do not produce TNF-a nor its receptor

43 1Isabelle Mancini, Alain Bosseloir, Elisabeth Hooghe-Peters, Ernst Heinen ,

and Uon Sima r

Splenic lesions in hypogammaglobulinaemia

43 7J . Weston, B .M. Balfour, W. Tsohas, N. English, J . Farrant and

A.D .B . Webster

Ontogenic study on the bronchus associated lymphoid tissue (BALT) in the rat ,with special reference to dendritic cells 44 3

Yoshifusa Matsuura, Nobuo Imazeki, Akira Senoo, and Yusuke Fuse

DRC1 expression on lymphoid normal and pathological cells

449Nadine Antoine, Ernst Heinen, Christian Marcoty, Alain Bosseloir an d

Leon Simar

Binding of HIV-1 to human follicular dendritic cells 45 5Piet Joling, Leendert J . Bakker, Dick F. van Wichen, Loek de Graaf, Timo

Meerloo, Maarten R . Visser, Jos A .G . van Strijp, Jaap Goudsmit, JanVerhoef, and Henk-Jan Schuurman

Follicular dendritic cells in germinal center reactions

46 1John G. Tew, Gregory F . Burton, Leo I . Kupp and Andras Szakal

PANEL DISCUSSION ON DENDRITIC CELL NOMENCLATUR E

Follicular dendritic cells and dendritic cell nomenclature

467John G . Tew

Langerhans cells as outposts of the dendritic cell system

469A.H. Warfel, G .J . Thorbecke and D .V. Belsito

Heterogeneity of dendritic cells and nomenclature

48 1Elisabeth C .M. Hoefsmit, Joanne M .S. Arkema, Michiel G .H. Betjes ,

Cann E.G. Havenith, Ellen van Vugt, Robert H.J . Beelen and EduardW.A. Kamperdijk.

Report of the panel discussion

487Elisabeth C .M. Hoefsmit

DENDRITIC CELLS IN CLINICAL IMMUNOLOG Y

Dendritic cells in transplantation

489

Jonathan M . Austy n

Down-regulation of MHC-expression on dendritic cells in rat kidney grafts b yPUVA pretreatment 49 5

B. v . Gaudecker, R . Petersen, M . Epstein, J . Kaden, and H . Oesterwit z

Cytokine mediators of non-lymphoid dendritic cell migration

50 1Justin A . Roake, Abdul S . Rao, Christian P . Larsen, Deborah F . Hankins ,

Peter J . Morris, and Jonathan M . Austy n

Isolation of dendritic leukocytes from non-lymphoid organs

507Abdul S . Rao, Justin A . Roake, Christian P . Larsen, Deborah F . Hankins ,

Peter J .Morris and Jonathan M . Austyn

RTIB/D+ non-lymphoid DC in early GVHD and Hg-induced autoimmunity ofrat salivary and lacrimal glands 51 3

Ake Larsson, Kouji Fujuwara and Michael Peszkowsk i

In-vitro infection of peripheral blood dendritic cells with huma nimmunodeficiency virus-1 causes impairment of accessory functions . . . 521

Jihed Chehimi, Kesh Prakash, Vedapuri Shanmugam, Stephanie J . Jackson ,Santu Bandyopadhyay, and Stuart E. Starr

Simian immunodeficiency virus (SIV) induced alterations of thymus IDCs . . . . 527V . Krenn, J . Müller, W. Mosgöller, S . Czub, C . Schindler, C . Stahl-Hennig ,

C. Coulibaly, G . Hunsmann, and H .K. Müller-Hermelink

Murine leukaemia virus infections as models for retroviral disease in humans . . 533Mary S . Roberts, Jennifer J . Harvey, Steven E . Macatonia, and Stella

C . Knigh t

Langerhans cells and interdigitating cells in HIV infection

53 9Andrea M .R. von Stemm, Julia Ramsauer, Klara Tenner-Racz, Heidemarie

F . Schmidt, Irma Gigli, and Paul Racz

Dendritic cells in HIV-1 and HTLV-1 infection

54 5Stella C . Knight, Steven E . Macatonia, Kennedy Cruickshank, Peter Rudge ,

and Steven Patterson

Dendritic cells in allergic and chronic inflammatory responses

55 1Leonard W . Poulter and George Janossy

Pulmonary dendritic cell populations

55 7Patrick G. Hol t

Blood dendritic cells are highly adherent to untreated and cytokine-treatedcultured endothelium 563

K.Alun Brown, Frances LeRoy, Penelope A. Bedford, Stella C . Knight andDudley C. Dumonde

Antigen specific T cell priming in vivo by intratracheal injection of antigenpresenting cells 57 1

Carin E .G . Havenith, Annette J . Breedijk, Wim Calame, Robert H.J . Beele nand Elisabeth C .M. Hoefsmi t

Histology and immunophenotype of dendritic cells in the human lung

57 7Jan Maarten W . van Haarst, Harm J . de Wit, Hemmo A . Drexhage and Henk

C. Hoogsteden

Acquisition of Chlamydial antigen by dendritic cells and monocytes

58 1Andrew J . Stagg, Arthur Stackpoole, William J. Elsley and Stella C . Knigh t

Experimental cutaneous leishmaniasis : Langerhans cells internalize Leishmaniamajor and induce an antigen-specific T-cell response 58 7

Heidrun Moll

Endocytosis of potential contact sensitizers by human dendritic cells

59 3Marie Larsson and Urban Forsu m

Dendritic cells and "dendritic" macrophages in the uveal tract

59 9John V. Forrester, Paul G . McMenamin, Janet Liversidge and Lynne Lumsde n

Macrophages and dendritic cells in rat colon in experimental inflammator ybowel disease 60 5

Emmelien P . van Rees, Marsetyawan Soesatyo, Marja van der Ende, an dTaede Sminia

Vaccination with tumor antigen-pulsed dendritic cells induces in vivo resistance t oa B cell lymphoma 61 1V. Flamand, T . Sornasse, K . Thielemans, C . Demanet, O . Leo, J . Urbai n

and M. Moser

Studies on Langerhans cells in the tracheal squamous metaplasia of vitamin Adeficient rats 61 7

Satoru Hosokawa, Masanori Shinzato, Chiyuki Kaneko and Mikihiro Shamot o

Depletion of Langerhans cells following carcinogen treatment is partly due t oantigenicity 623

Gregory M . Woods, Imogen H . Liew and H. Konrad Muller

A proportion of patients with premature ovarian failure show lowere dpercentages of blood monocyte derived dendritic cells capable o fforming clusters with lymphocytes 629

Annemieke Hoek, Yvonne van Kasteren, Meeny de Haan-Meulman, Joo pSchoemaker, and Hemmo A . Drexhage

Thyroid hormones and their iodinated breakdown products enhance th ecapability of monocytes to mature into veiled cells . Blocking effects ofa-GM-CSF 63 3

P. Mooij, M. de Haan-Meulman, H.J . de Wit and H .A. Drexhage

Relationship between dendritic cells and folliculo-stellate cells in the pituitary :Immuno-histochemical comparison between mouse, rat and humanpituitaries 637

W. Allaerts, P .H.M. Jeucken, F .T . Bosman and H.A . Drexhage

Dendritic cells in tumor growth and endocrine diseases

64 3H.A. Drexhage, P . Mooy, A . Jansen, J . Kerrebijn, W . Allaerts an d

M.P.R. Tas

Index 651