december 2000 the benefits of giving the whittier e. dailey, iii, m.d. edward w. holmes, m.d. vivian...

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  • December 2000

    Scripps Whittier Diabetes Program

    Scripps/UCSD/Whittier Diabetes Research Program

    Community Diabetes Care Program/Project Dulce a program in partnership with

    Community Health Improvement Partners

    Sisters with a Special Bond

    New Faces at the Whittier

    Diabetes and the Holidays

    Hearty White Chi l i

    The Whittier Institute for Diabetes,a subsidiary of Scripps, is dedicated to

    diabetes research, education and patient carethrough a collaborative program with

    the University of California, San Diego.

    The Whittier Institute Board of Trustees

    Chairman: Maurice R. Taylor IIVice Chairman: Gobind SahneyCorporate Secretary: Jackie SingerTreasurer: Bryce W. RhodesPresident/CEO: John B. Engle

    David H. BartramEarl K. BeitzelCharles H. BrandesMartin B. BuserGeorge E. Dailey, III, M.D.Edward W. Holmes, M.D.Vivian M. Leith Robert F. ListJohn MesserschmittBerlyn D. MillerDon W. Mitchell, Esq.Jerrold M. Olefsky, M.D.Margery A. PerryJanet A. Rodgers, Ph.D.Charles E. ScribnerRichard R. Sheridan, Esq.Marilyn B. Tedesco

    Honorary TrusteesRichard C. Atkinson, Ph.D.Brian BilbrayWillard P. VanderLaan, M.D.William C. Winter, M.D.

    Scripps/UCSD/Whittier DiabetesResearch Program Committee

    Scientific Director: Jerrold M. Olefsky, M.D.

    Clyde H. Beck, Jr., M.D.George E. Dailey III, M.D.John B. EngleAlberto Hayek, M.D.Kenneth L. Jones, M.D.Stanley A. Mendoza, M.D.George E. Palade, M.D.Margery A. PerryBryce W. RhodesRichard R. Sheridan, Esq.Daniel Steinberg, M.D.Samuel S.C. Yen, M.D.

    Whittier Diabetes ProgramPrincipal Investigators

    Theodore Ciaraldi, Ph.D.Vincenzo Cirulli, M.D., Ph.D.George E. Dailey III, M.D.Wolfgang Dillmann, M.D.Steve V. Edelman, M.D.Alberto Hayek, M.D.Robert R. Henry, M.D.Yolanta Kruszynska, M.D.Fred Levine, M.D., Ph.D.Jerrold M. Olefsky, M.D.Wulf Palinski, M.D.Athena Philis-Tsimikas, M.D.Henry C. Powell, M.D.Peter D. Reaven, M.D.David Rose, Ph.D.Daniel Steinberg, M.D.Nicholas J.G.Webster, Ph.D.Joseph L. Witztum, M.D.Patricia Wu, M.D.

    As the year draws to a close, now is a good time to consider the

    many options for year-end giving. The

    holidays are a very special time to give

    charitable donations. Here are a few

    options you might want to consider:

    Cash gifts may be deducted from your

    federal income tax return up to 50

    percent of your adjusted gross income.

    A gift of long-term appreciated

    securities lets you deduct the full

    fair market value of your investments

    and avoid any tax on the capital gain.

    A gift of securities, or any appreciated

    property, is deductible up to 30 percent

    of your adjusted gross income.

    You may donate your personal

    residence, live there for the rest of

    your life, and receive a lifetime fixed

    income based on the value of your

    home. You will also receive an

    immediate income tax deduction for

    the contribution.

    For more information about how to advance diabetes care and make

    a tax-smart gift, call Roz Hodgins,

    Director of Development, at


    The Benefits of Giving

    9894 Genesee AvenueLa Jolla, California

    Non-profit organization U.S. Postage

    PAIDpermit No. 1981 San Diego, CA

  • page threepage two

    Donor Profile:Twin Sist ers Support Ea ch Other

    Research Findings Lead to New Theory

    Being twins, Mollie and Jackie Singershare a special bond. Another condition

    brings them even closer together. You see,

    Mollie was diagnosed with juvenile

    diabetes, also known as Type1diabetes,

    at the age of four. For the past six months

    Mollie has successfully worn a MiniMed

    Insulin Pump. Prior to the pump, Mollies

    daily ritual for the last six years included

    taking up to six shots of insulin, testing

    her blood sugar level an average of ten

    times, and then eating and playing accord-

    ing to the levels. She no longer takes

    injections, but the rest of her disciplined

    life remains the same. Not wanting her

    sister to go through the disease alone, the

    two 11-year-olds have banded together

    to take on diabetes. They currently travel

    the country with their Mother, teaching

    the world about Mollies illness.

    Not only have they spoken with politi-

    cians, doctors and researchers, they have

    testified at a Senate Hearing, written a

    short book entitled The Road to the Cure,

    and have formed a support group called

    Mollies DAs, or Diabetic Angels. Even

    though the angels dont have diabetes them-

    selves, they use their knowledge to assist in

    caring for someone who does or to educate

    others, including teachers and parents.

    The twins mother, also named Jackie,

    tells the story of a nine year old girl

    whose grandfather went into diabetic

    shock at the Thanksgiving dinner table.

    The girl was a Diabetic Angel and the

    only one in her family who knew what

    to do. She saved her grandfathers life

    because she chose to make a difference.

    Over the years, as the Singer family

    learned more about diabetes research

    and admired the work done through the

    Whittier, Jackie decided to get more

    involved and contributed her time and

    public relations skills. She currently serves

    as Corporate Secretary on The Whittier

    Board of Trustees.

    People, even children, have the power

    to do so much, says Jackie. Diabetes is

    not an individual disease it affects the

    whole family. Just as families support

    each other, we all need to support

    finding a cure for the 16 million

    Americans who currently live with


    Being a child with diabetes, Mollie

    has many obstacles to overcome that

    other kids her age take for granted. For

    instance, when she gets sick, it takes

    her much longer to recover. Once, due

    to illness, Mollie missed five weeks of

    school. Yet, through extra hard work

    on her part, she was still able to

    maintain a 3.8 grade point average.

    I try to take good care of myself and

    manage my diabetes so I can live my

    life to the fullest, but I can never take

    a vacation from my diabetes, says

    Mollie. I really hope they find a cure

    for diabetes soon. Im lucky because I

    have a special sister, Jackie. She makes

    life a lot of fun and makes living with

    diabetes easier together we can

    overcome anything.

    When they are not traveling the

    country on a tireless mission, Mollie

    and Jackie enjoy roller blading,

    biking and visiting the beach to

    swim and ride the waves together.

    Dr. Jerrold Olefsky, ScientificDirector of the Scripps/UCSD/Whittier

    Diabetes Research Program, along with

    his team of researchers know the number

    one rule of science question everything.

    Yet, they were still surprised when all of

    their scientific tests didnt support a widely

    accepted theory as to how Type 2 diabetes

    drugs on the market work within the body.

    Currently, there are two types of thiazo-

    lidinedione (TZD) insulin-sensitizing drugs

    on the market for treating Type 2 diabetes

    Actos and Avandia. These TZDs attempt

    to overcome insulin resistance and make

    the diabetics tissues more able to respond

    to the insulin secreted from the pancreas.

    A major challenge for the diabetes research

    community has been trying to explain

    precisely how these drugs work within the

    body. A widely accepted belief has been

    that the diabetes drugs bind to a specific

    protein, called the PPAR gamma receptor,

    and this binding stimulates the production

    of a variety of genes that aid in overcoming

    insulin resistance.

    The research team, consisting of Philip

    Miles, Yaacov Barak, Weiman He, Ronald

    Evans and Jerrold Olefsky, decided to

    investigate this theory further. Using the

    techniques of mouse genetics, they were

    able to manipulate genetic codes of mice

    and alter the genes. Eventually, the PPAR

    gamma receptor gene was knocked out,

    which offered surprising results. The mice

    without a PPAR gamma receptor were not

    insulin resistant, as was previously hypoth-

    esized. Rather, the animals were extremely

    sensitive to insulin and were protected from

    diabetes. To ensure the results were accurate,

    Dr. Olefskys group repeated this particular

    experiment more than any other procedure

    in past research. Yet, the test outcomes

    continued to remain the same, and the

    researchers finally came to the conclusion

    that the accepted theory was inaccurate.

    Their evidence showed just the opposite

    diabetes drugs on the market do bind to the

    PPAR gamma receptor, but they more

    likely work by inhibiting the protein, not

    activating it as previously believed. Within

    the last few months, this new theory has

    been supported by additional experiments,

    and outside laboratories have confirmed

    the results.

    Armed with these new findings, the

    research community as well as pharma-

    ceutical companies can create more

    effective drugs to combat diabetes. In fact,

    this will aid in finding drugs that not only

    improve insulin resistance, but also prevent

    Type 2 diabetes before its onset, which

    could then be administered to specific

    high-risk populations.

    As you may have noticed,The Whittier Diabetes Report has a new

    look. Weve combined The Whittier and

    Project Dulce newsletters, inc