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Dear Colleague,

The management of critically ill patients continues to evolve. Recent advances in biologycoupled with careful observations in patients have provided new knowledge of disease mech-anisms and identified potential targets for intervention. However, applying this informationto improve outcomes from critical illness is still a work in progress. Common problemsinclude identifying optimal targets and approaches for resuscitation to maintain tissueperfusion, defining the best therapeutic intervention to sustain organ function, knowing whento intervene with extracorporeal support techniques and when to initiate end of life care. Asystematic approach to this problem requires an understanding of the pathophysiologicmechanisms involved, techniques to ascertain the stage of the disease and it relationship tothe natural history, knowledge of the therapeutic potential and experience with the optimalstrategies that can improve outcomes. Care of the critically ill patient requires a constantupdating of knowledge, skills and application of best practices. The twelfth international con-ference on CRRT highlights the recent advances in our understanding of pathophysiology ofcritical illness, emerging strategies in the management of sepsis, multi-organ failure, acutekidney injury, technical advances in CRRT and the appropriate utilization of these techniques.

As in past years, we have invited internationally recognized experts to discuss several topicsthat reflect contemporary issues faced by the clinician treating patients in the ICU. A reviewof the pathophysiology of organ failure is complemented by information on how best to resus-citate patients. Kidney injury and its consequences, modulation of organ dysfunction withextracorporeal techniques and innovations in cardiac and hepatic support are other topicsdiscussed. The emerging field of biomarkers is covered in a series of lectures complementedby two workshops that will explore the utility of these markers for diagnosis, prognosis andmanagement of patients. New technology for the diagnosis, monitoring and treatment of thecritically ill patient is now being utilized and its application is described. This year's programfocuses on providing practical information to translate new knowledge from the bench to thebedside. This is achieved with a mix of invited lectures, workshops, poster sessions and paneldiscussions. Specific topics on nursing care, nutritional support and other process of careelements are incorporated in different sessions to promote multidisciplinary understandingand collaborative approaches to patient care. A key goal of the conference is to equip partic-ipants with the most up to date and practical knowledge for patient care. Consequently, wehave introduced new “hands-on” workshops deigned to provide detailed instruction on theuse of specific equipment for extracorporeal support. More time has been allocated fornetworking to continue the tradition of multidisciplinary interactions, which are a highlightof this conference. As always, we hope to provide the right environment to foster learning andmutually beneficial communications and collaborations. We hope that you will join us toshare your knowledge and experience as it is through multidisciplinary interactions that wewill gain a better understanding of critical illness and it is only through our collective effortsthat we will improve the lives of our patients.

We look forward to welcoming you to San Diego for the twelfth time.

Ravindra L Mehta, MDChairman, Organizing Committee

TwelfTH INTERNATIONAL CONFERENCE ON CONTINUOUS RENAL REPLACEMENT THERAPIES

USASteven R. Alexander, MD

Geraldine Biddle, RN, CNN, CPHQJoseph V. Bonventre, MD, PhD

Timothy E. Bunchman, MDJorge Cerda, MD

Glenn M. Chertow, MDWilliam R. Clark, MDStuart Goldstein, MD

Thomas A. Golper, MDDavid B. Hoyt, MD, FACS

Andre A. Kaplan, MDWilliam L. Macias, MD, PhD

Rhonda K. Martin, RN, MS, CCRN, CNS/ACNP-C

Bruce Mueller, PharmD, FCCPEmil P. Paganini, MD, FACP, FRCP

Maria Pascual, RN, BSN, MPHBrian J.G. Pereira, MD

David M. Ward, MD, FRCP

SOUTH AMERICAEmmanuel Burdmann, MD, PhD

CANADANoel Gibney, MD

Martine Leblanc, MD, FRCPCSheldon Tobe, MD

EUROPEBernard Jean-Marie Canaud, MD

Andrew Davenport, MDPatrick Honore, MD

Didier Journois, MD, PhDClaudio Ronco, MD

Miet Schetz, MD, PhDRaymond Vanholder, MD, PhD

JAPANTadao Akizawa, MD

Hiroyuki Hirasawa, MD, PhD

CHINALei-shi Li, MD, FHKCP

AUSTRALIAIan Baldwin, RN, MN, ACCCNRinaldo Bellomo, MD, FRACP

ORGANIZING COMMITTEECHAIRMAN

Ravindra L. Mehta, MD, FACP

Deadline for receipt of abstracts December 11, 2006Notification of abstract acceptance January 5, 2007Postmark/Online deadline for early registration January 11, 2007Hotel Reservation Deadline February 1, 2007On-site Registration Fees March 5-10, 2007Poster Mounting and Viewing March 8, 2007Conference and Workshop Sessions March 7-10, 2007NEW Hands-on Workshops (Electives)

Gambro March 7, 2007Fresenius March 10, 2007CHF Solutions March 10, 2007Baxter Edwards Critical Care Alliance March 10, 2007Pediatric March 10, 2007

IMPORTANT CONFERENCE DATES

Endorsed by

The International Society of Nephrology

Acute Kidney Injury Network

INDIAVijay Kher, MD, DM, FAMS, FISN, FIMSA

Rajasekara Chakravarthi, MD, DNB

PARTICIPATING FACULTY (Partial List)Steven R. Alexander, MDStanford University Medical Center

Stanford, CA

Linda Awdishu, BSc, Pharm DUCSD Medical Center

San Diego, CA

Ian Baldwin, RN, MN, ACCCNDepartment of Intensive Care

Austin Hospital

RMIT University

Melbourne, VI AUSTRALIA

Arthur R. Bradwell, MDUniversity of Birmingham

Birmingham, UK

Timothy E. Bunchman, MDDeVos Children's Hospital

Grand Rapids, MI

Emmanuel Burdmann, MD, PhDSao Jose do Rio Preto Medical School

Sao Jose do Rio Preto, SP Brazil

Jorge Cerda, MD, FACPCapital District Renal Physicians

Albany, NY

Rajsekara Chakravarthi, MD, DNBCare Hospitals

Institute of Medical Sciences

Hyderabad, AP INDIA

William R. Clark, MDGambro US

Lakewood, CO

Andrew Davenport, MD, MARoyal Free Hospital

London, ENGLAND (UK)

Dan Davis, MDUCSD Medical Center

San Diego, CA

Wilfred Druml, MDUniversity of Vienna

Vienna, AUSTRIA

James D. Fortenberry, MDEmory University School of Medicine

Children's Healthcare of Atlanta at Egleston

Atlanta, GA

Noel Gibney, MDUniversity of Alberta

Edmonton, Alberta CANADA

Stuart L. Goldstein, MDTexas Children's Hospital

Houston, TX

Patti Graham, RN, MSN, CNS,CCRNUCSD Medical Center

San Diego, CA

Stefan Herget-Rosenthal, MDUniversity Hospital

University Duisburg-Essen

Essen, GERMANY

Jonathan Himmelfarb, MDMaine Medical Center

Maine Medical Center Research Institiute

Portland, ME

Patrick M. Honore, MDSt-Pierre Para Universitary Hospital

Leuven, BELGIUM

Bertrand Jaber, MDCaritas St. Elizabeth's Medical Center

Tufts University School of Medicine

Boston, MA

John Kellum, MD, FCCM, FACPUniversity of Pittsburgh School of Medicine

Pittsburgh, PA

Vijay Kher, MD, DM FAMS, FISN, FIMSAFortis Hospitals

New Delhi, INDIA

Michael Kraus, MDIndiana University

Indianapolis, IN

Giancarlo Marenzi, MDUniversity of Milan

Milan, ITALY

Mark Marshall, MBChB, FRACPUniversity of Auckland

Auckland, NEW ZEALAND

Rhonda K. Martin, RN, MS, CCRN, CNS/ACNP-CUCSD Medical Center

San Diego, CA

Ravindra L. Mehta, MD, FACPUniversity of California, San Diego

School of Medicine

San Diego, CA

Bruce A. Mueller, PharmD, FCCPUniversity of Michigan

Ann Arbor, MI

Mark Okusa, MDUniversity of Virginia

Charlottesville, VA

Emil P. Paganini, MDCleveland Clinic Foundation

Cleveland, OH

Maria Pascual, RN, BSN, MPHUCSD Medical Center

San Diego, CA

Michael Pinsky, MDUniversity of Pittsburgh

Pittsburgh, PA

Emmanuel P. Rivers, MDEmergency Medicine and Critical Care

Henry Ford Hospital

Detroit, MI

Claudio Ronco, MDDepartment of Nephrology

Vicenza, ITALY

Miet Schetz, MD, PhDUniversity Hospital Gasthuisberg

Leuven, BELGIUM

Christian Schlaeper, MSFresenius Medical Care

Walnut Creek, CA

Boyd Taylor Thompson, MDMassachusetts General Hospital

Boston, MA

Ashita Tolwani, MDUniversity of Alabama at Birmingham

Birmingham, AL

James Tumlin, MDCarolinas Medical Center-Union

Monroe, NC

David Ward, MD, FRCPUCSD Medical Center

San Diego, CA

Lee Ware, RNBaxter Healthcare Corporation

Deerfield, IL

Visit the conference website for the most current program information, abstractsubmission, online registration and online hotel reservations.

www.crrtonline.com

CONFERENCE DATES AND LOCATIONThe inclusive dates for all scientific sessions of the TWELTH INTERNATIONAL CONFERENCE ONCONTINUOUS RENAL REPLACEMENT THERAPIES (CRRT) are March 7-10, 2007. The Conferencewill be held at the Hotel del Coronado, 1500 Orange Ave., Coronado, California. Tel: 1 (800) 468-3533 (reser-vations), 1 (619) 435-6611 (hotel), Fax: 1 (619) 522-8262. For hotel accommodations delegates may mail theform in this brochure or use our conference website hotel link. A limited number of rooms at special confer-ence rates are available, so make your reservation as soon a possible. If you phone the hotel directly for reser-vations, identify yourself as a delegate to the CRRT Meeting.

Hotel reservations may be made online by visiting the conference website at www.crrtonline.com

REGISTRATION INFORMATIONPlease visit our website to register, or use the form at the back of this brochure.All participants must register and pay the appropriate fee. Conference registrants will have access to all sci-entific sessions and poster sessions. The registration fee includes general sessions, workshops, CME accred-itation, conference syllabus, continental breakfasts, coffee breaks, receptions and lunch on Thursday andFriday. Registration will begin on the evening of March 7th. Poster Viewing will begin on Thursday eveningMarch 8th. For additional registration times see the program.

REGISTRATION FEES Early Bird Pre-Registration RegistrationOn or before January 12 thru March 5 thru

January 11, 2007 March 4, 2007 March 10, 2007On-Site

Physicians (MD, PhD, etc.) $ 595 $ 665 $ 730

Nurses/Dieticians/IndustryPharmacists/Residents*/Fellows* $ 405 $ 475 $ 540*with letter of verification from department head

Conference Registration Fee Includes: Access to all general sessions, workshops (Thurs-Fri)Exhibit Area, Welcome Receptions on Thursday & Friday and lunches on Thursday & Friday.Conference Registration Fee does not include Elective Hands-On Workshops (see below).

ELECTIVE HANDS-ON WORKSHOPSNEW this year… we are providing elective “hands-on” workshops that will provide detailedinstructions on the use of CRRT equipment. Each workshop will provide training on the useof the device including setup, operations, monitoring and alarm conditions. Workshops havelimited slots to maximize opportunity for each participant to learn how to operate the equip-ment. These workshops are a unique opportunity to acquire or refresh skills with differentCRRT equipment.

HO1: Gambro Prismaflex Hands-On Workshop (limited enrollment) $125Wednesday, March 7th 9:00am – 4:30pm (includes lunch & AM/PM breaks)

Training on setup, connections, operations, monitoring and troubleshooting for the Prismaflexplatform system for patients requiring various modalities of CRRT.

Hands-On Workshops continue on following page

GENERAL INFORMATION

Concurrent Hands-On Workshops (select one - limited enrollment) $75

Saturday, March 10th 1:00 – 5:00pm (includes lunch & PM break)

HO2: Fresenius Workshop “SLED , EDD and CRRT with the K machines”Learn how to us the Fresenius system for CRRT, SLED and EDD

HO3: Baxter & Edwards Critical Care Nephrology Alliance: Accura & Aquarius Hands On SessionTake advantage of an opportunity to work directly with an Accura or Aquarius to better understand the flexibility of these machines and the benefits they can offer you.Focus areas are: Machine set up, machine priming, machine programming and managing a treatment.

HO4: CHF Solutions “The Aquadex FlexFlow System”Use of Aquapheresis and the Aquadex FlexFlow in fluid overload states.

HO5: Pediatric Hands-on WorkshopHow to prescribe and deliver CRRT for neonates and pediatric patients, including machine setup operations monitoring and managing alarm conditions.

GUEST FEES $150Includes: Access to Exhibit Area, Welcome Receptions (Thursday), Meet the FacultyReception (Friday) and two Lunches (Thursday & Friday). Guests are not admitted to theGeneral Sessions or Workshops.

SOCIAL ACTIVITIESThere will be a Welcome Reception for Conference Registrants on Thursday evening, March8th (7:00pm-8:30pm) and a Meet the Faculty Reception on Friday evening March 9th(5:30pm-7:00pm).

Poster Session & Exhibit Reception Thursday, March 8th - 7:00pm-8:30pmMeet and interact with your poster presenters and review the latest in equipment and prod-ucts at this informal reception.

Meet the Faculty Reception Friday, March 9th - 5:30pm-7:00pmMeet your faculty and network with your colleagues at the Hotel Del.

TOURSWe will provide elective tours for our conference guests. Advanced reservations will berequired to guarantee availability. Visit our CRRT web site for details.

Coronado Walking Tour Adult/Child $12Thursday, March 8th (10:45am-12:30pm) Meet on the front lawn

Coronado is a small “island” town in San Diego bay, approximately 7.4 square miles in size.Crown City, as it is called (Coronado means "crowned one" in Spanish), regards itself as afriendly, small town of wide leafy streets lined with Victorian homes and Californian bunga-lows. Coronado’s award-winning beach was recently ranked second best in the country bythe Travel Channel, is a special jewel.

Our Coronado Tour is a 90-minute guided walking tour of historic areas in Coronado. Thetour will depart from the Glorietta Bay Inn (across the street from our conference site) andformer mansion of John D. Spreckels.

GENERAL INFORMATION

continued

GENERAL INFORMATION

San Diego Trolley Car Tour Adult $30 Child $14Friday, March 9th (9:30am-11:30am)

Come along with San Diego's best tour conductors as they combine colorful anecdotes,humorous stories and well researched historical information into a fast moving two hour narrative that's both entertaining and educational.

Join us as we turn back the pages of history and relive San Diego's early days as it became theBirthplace of California. In Old Town San Diego (sometimes called the "Jamestown of the Pacific"),you will experience early Americana with its distinctive "West Coast Style" Spanish flavor.

See and Visit... Old Town State Park, Seaport Village, Horton Plaza, Coronado Island, SanDiego Zoo, Gaslamp Quarter, San Diego Museum of Art, Natural History Museum,Aerospace Museum, Lindbergh Field, Naval Station San Diego, Balboa Park, El Prado,Heritage Park, Star of India, Whaley House... and much, much more!

ACCREDITATIONThis activity has been planned and implemented in accordance with the Essential Areas andpolicies of the Accreditation Council for Continuing Medical Education ("ACCME") throughthe joint sponsorship of the University of California, San Diego School of Medicine and theCRRT, Inc. The University of California, San Diego School of Medicine is accredited by theACCME to provide continuing medical education for physicians.

The University of California, San Diego School of Medicine designates this educational activ-ity (including elective Hands-On Workshops) for a maximum of TBA Category 1 credit(s)toward the AMA Physician's Recognition Award. Each physician/RN/allied professionalshould claim only those credits that he/she actually spent in the activity.

The American Medical Association has determined that physicians not licensed in the U.S. whoparticipate in this CME activity are eligible for AMA PRA Category 1 International credit.

California Board of Pharmacy accepts AMA/PRA Category 1 credit for continuing education.

BRN: Under the California BRN guidelines, this course is accredited for up to TBA hours ofnursing credit. California Board of Registered Nursing, Continuing Education Provider#CEP55. The conference will not be offering ANNA specific accreditation this year.

AAPA: Accepts Category 1 AMA PRA credit(s) from organizations accredited by the ACCMEto grant Category 1 credit(s).

CANCELLATION POLICYIf your registration must be cancelled, your fee, less $100 U.S. for administrative costs, will berefunded upon your written request. No refunds will be made after February 9, 2007. Allow 6-8 weeks for refund.

CONFERENCE OFFICE/INFORMATIONRES Seminars. Phone: 858-272-1018 4425 Cass Street, Suite A Fax: 858-272-7687San Diego, CA 92109 USA Email: [email protected]

Conference Website: crrtronline.com

8:00-9:30 SIMULTANEOUS WORKSHOPS GROUP 1 A01* CRRT Systems I (C,N,AP)

I. B. Braun Diapact IIII. Baxter - Edwards Lifesciences CriticalCare Nephrology Alliance Accura/AquariusDevice demonstrations of features, setup, operation, monitoring and discontinuation.

B02 Dialysis Dose Prescription and Delivery 1 (C,N)Operational characteristics influencing solute removal in IHD, PD and CRRT

C03 Vascular Access /Membrane and Circuit 1 (C,N,AP)Principles of catheter choice, placement, maintenance, recognition and management ofcomplications, selection and use of membranesfor different applications, circuit design, setup and monitoring, prevention of infection

D04 Resuscitation 1 (C,N,AP)Principles of resuscitation for the critically ill patient

E05 Pediatric CRRT: The Basics (I,N,AP)Technique requirement and application for use in children including neonates.

F06 Extracorporeal Techniques for Sepsis 1 (A)Pathophysiology of sepsis and rationale for use of extracorporeal support in treatment of sepsis. Experimental models for high permeability membranes, HVHF, VHVHF and hybrid therapies

G07 Plasma Exchange Therapy and Hybrid Techniques 1 (A)Principles of plasma exchange, sorbent based and hybrid therapies for extracorpo-real support. Results from experimental models and human studies

9:30-9:45 Coffee Break

9:45-11:15SIMULTANEOUS WORKSHOPSGROUP 2 A08* CRRT Systems II (C,N,AP)

I. RenaMed BiologicsII. NxStage Therapy SystemDevice demonstrations of features, setup, operation, monitoring and discontinuation.

B09 Anticoagulation 1: Mechanisms and Techniques (C)Anticoagulation regimens: Mechanisms, selection, prescription, monitoring and implementation.

C10 Fluid Management 1 (I,N,AP)Principles of volume assessment, fluid removal and fluid regulation with different CRRT equipment

D11 Acid Base and Electrolyte Problems inthe Critically Ill 1 (I,N,AP)Principles and diagnosis of common acid base and electrolyte problems in the critically ill patient.

WEDNESDAY, MARCH 7

THURSDAY MORNING, MARCH 8

8:00am Registration for Wednesday’s Elective Hands-On Workshop 9:00am-4:30pm HO1 Gambro Prismaflex Hands-On Workshop

Training on setup, connections, operations, monitoring and troubleshooting for the Prismaflexplatform system for patients requiring various modalities of CRRT.

9:00-10:30 SESSION 110:30-10:45 Coffee Break10:45-12:15pm SESSION 212:15-1:15 Lunch Hosted by Conference for Workshop Participants1:15-2:45 SESSION 32:45-3:00 Coffee Break3:00-4:30 SESSION 4

5:30-8:00pm Conference Registration Opens

PROGRAM

7:00am-7:30pm Registration

8:30am- 4:15pm WORKSHOPS (open to all participants - applicable to physicians, nurses and allied personnel)(Codes: C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = of interest to nurses and allied personnel)

Workshops designated by an asterisk (*) will be presented twice in different time slots.

Workshops presented in a series are marked with a “1” for a primary workshop discussion in this areaand “2” for a more complex or advanced discussion in this area. Please note that the series workshops 1and 2 can be either taken subsequently (following each other) or they can each be taken independently (e.g.workshop 1 can be taken without taking workshop 2 and vice versa).

THURSDAY AFTERNOON, MARCH 8

E12 Organizational Aspects of CRRTPrograms 1: Development and Implementation (C,N,AP)Practical issues for organization and implementation of a CRRT program. Developing and implementing policies and protocols for CRRT

F13 Heart Failure and Cardio-Renal Syndrome 1 (I)Pathophysiology, recognition and managementstrategies for cardiac and renal failure in the critically ill patient

G14 Therapy Comparisons 1: SLED vs. CRRT vs. PD (I,N,AP)Comparisons of operational characteristics including anticoagulation, membranes, solutions and flows and approaches for ongoing and future research.

11:15-12:45 Lunch Hosted by Conference

12:45-2:15SIMULTANEOUS WORKSHOPS GROUP 3A15* CRRT Systems III (C,N,AP)

I. Gambro PrismaflexII. Fresenius SystemsDevice demonstrations of features, setup, operation, monitoring and discontinuation.

B16 Solutions for CRRT 1 (I,N) Basic concepts for formulation and applicationof various solutions for pre-dilution, replacementand dialysate in critically ill patients.

C17 Drug Management 1 (I,N,AP)Dosing principles for critically ill patients andadjustments in extracorporeal support techniques.

D18 Nutritional Assessment and Support 1 (I, N)Pathophysiology of malnutrition in criticallyill patients. Principles of nutritional assessment and support.

E19 A Systems-based Approach to CRRT 1 (A,N,AP)Principles of systems based management strategiesand their application to CRRT. Approaches to reduce errors in therapy prescription and delivery.

F20 Liver and the Kidney 1 (A)Pathophysiology of hepatic failure and rationalefor use of different techniques for extracorporealsupport techniques (Cell based systems, MARS, CRRT) for hepatic support.

G21 Biomarkers 1 (I,N) Principles and classification of biomarkers and their application for diagnosis and management of diseases. Criteria for using biomarkers as surrogate end points.


2:30-4:00SIMULTANEOUS WORKSHOPS GROUP 4 A22* CRRT Systems I (C,N,AP)

I. B. Braun Diapact IIII. Baxter - Edwards Lifesciences CriticalCare Nephrology Alliance Accura/AquariusDevice demonstrations of features, setup, operation, monitoring and discontinuation.

B23 Dialysis Dose Prescription and Delivery 2 (I)Case based discussions of prescription of dose,modality choice and optimal dose delivery to match the therapy to the patients need.

C24 Vascular Access/Membrane and Circuit 2 (C,N,AP)Case based discussion of various factors influ-encing circuit longevity, membrane functionand troubleshooting for problems encountered.

D25 Resuscitation 2 (A,N,AP)Case studies using SIM-Man for resuscitation scenarios.

E26 CRRT in the New Born: Principles and Application Nursing Issues in Pediatric CRRT (I,N,AP)Practical issues for setting up and maintaininga pediatric CRRT program. Policies and procedures and protocol based management.

F27 Extracorporeal Techniques for Sepsis 2 (A)Technical considerations and practical appli-cation of extracorporeal support techniques for sepsis. Results of human studies for use of high permeability membranes, HVHF, VHVHF and hybrid techniques for sepsis.

G28 Plasma Exchange Therapy and Hybrid Techniques 2 (A)Case based discussion of practical applicationof plasma exchange, sorbent based and hybrid therapies for extracorporeal support.

OPENING SESSION

4:30 -7:00 Plenary 1 MINI-SYMPOSIAOrgan Dysfunction in the CriticallyIll Patient

4:30-4:35 Opening RemarksRavindra L Mehta, MD, FACP

4:35-4:55 Disordered Tissue Perfusion: The Final Common PathwayEmmanuel P. Rivers, MD

4:55-5:15 Predicting Lung Injury: Which MarkersBoyd Taylor Thompson, MD

continued

SESSION I: PATIENT CHARACTERISTICS

SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE

7:25-7:30am AnnouncementsRavindra L. Mehta, MD, FACP

7:30- 9:45 Plenary 2 MINI-SYMPOSIAAcute Kidney Injury (AKI): What’s New?

7:30-7:50 Mechanisms of Ischemic AKIMark Okusa, MD

7:50-8:05 Genetic determinants in AKI Bertrand L. Jaber, MD

8:05-8:20 Pediatric AKI: Do Biomarkers Predict Injury?Stuart L. Goldstein, MD

8:20-8:35 Recovery from AKI: Predictive FactorsJonathan Himmelfarb, MD

8:35-8:50 Long Term Prognosis of Patients with AKI: Is Intensive Care Worth It?Wilfred Druml, MD

8:50-9:05 Management of Cirrhotic Ascites: Can We Prevent AKI?Mark Okusa, MD

9:05-9:20 Challenging Cases 1TBN

9:20-9:45 SPECIAL LECTURE Acute Kidney Injury Network: A Strategy to Improve Outcomes from AKIRavindra L. Mehta, MD, FACP

9:45-10:00 Panel Discussion


10:30-12:45 Plenary 3MINI-SYMPOSIAControversies in Management of the Critically Ill Patient

10:30-10:50 Targeted Resuscitation: Strategies for SuccessEmmanuel P. Rivers, MD

10:50-11:10 Wet, Dry, and AKI: Just the FACTTs Boyd Taylor Thompson, MD

11:10-11:30 Rapid Response Teams: Do They Save Lives?Dan Davis, MD

11:30-11:45 ELSO and PALISI TrialsJames Fortenberry, MD

11:45-12:00 Infection control in the ICU: An UpdateMaria Pascual, RN BSN MPH


12:15-12:45 SPECIAL LECTURE Acid-Base Physiology in CriticallyIll Patients: Traditional vs Modern ApproachesJohn Kellum, MD, FACP


1:00-2:15 Lunch Hosted by Conference

FRIDAY MORNING, MARCH 9

PROGRAM

5:15-5:35 Cardio-Renal Syndrome TBN

5:35-5:55 Nutritional and Energy Requirements in Critical IllnessWilfred Druml, MD

5:55-6:15 Metabolic consequences of AKIJonathan Himmelfarb, MD

6:15-6:45 SPECIAL LECTURERenal Effects of Critical IllnessMichael Pinsky, MD


7:00-8:30 Welcome Reception Poster Viewing and Exhibits Open

THURSDAY AFTERNOON (continued), MARCH 8


2:15-3:45 SIMULTANEOUS WORKSHOPSGROUP 5 A29* CRRT Systems II (C,N,AP)

I. RenaMed BiologicsII. NxStage Therapy SystemDevice demonstrations of features, setup, operation, monitoring and discontinuation.

B30 Anticoagulation 2: Special TechniquesCitrate (A)Comparison of various techniques for regional citrate anticoagulation includingrequirements, setup, monitoring and results.

C31 Fluid Management 2 (I,N,AP)Case based discussion of application of techniques for fluid regulation in CRRT

D32 Acid Base and Electrolyte Problems inthe Critically Ill 2 (A)Case studies of common problems and strategies for management including use of dialytic therapies including CRRT

E33 Organizational Aspects of CRRTPrograms 2: Development and Implementation (C,N,AP)Case studies of proven techniques for growing and enhancing a CRRT program. Multidisciplinary teams, collaborative practice,Financial models and other strategies for success

F34 Heart Failure and Cardio-renal Syndrome 2 (A)Technical considerations, practical applicationand results of different methods to treat heart failure and cardio-renal syndrome

G35 Therapy Comparisons 2: SLED vs. CRRT vs. PD (A)Case Based Examples of SLED (daily and Continuous), PD (intermittent, tidal) and practical aspects for recognizing and managing complications and approaches for ongoing and future research.


4:00-5:30 SIMULTANEOUS WORKSHOPS GROUP 6 A36* CRRT Systems III (C,N,AP)

I. Gambro PrismaflexII. Fresenius SystemsDevice demonstrations of features, setup, operation, monitoring and discontinuation.

B37 Solutions for CRRT 2 (A) Case based discussions of applications of solutions for acid-base and metabolic control,electrolyte and divalent ion homeostasis.

C38 Drug Management 2 (I,N) Case based discussion of practical aspects for drug prescription, delivery and managementof drug interactions in CRRT.

D39 Nutritional Assessment and Support 2 (I)Case based discussion of technical and practical considerations for nutritional support with CRRT

E40 A Systems-based Approach to CRRT 2(A,N,AP)Case studies of applications of systems based approaches for problem solving and continuous quality improvement in CRRT. Strategies to implement best practices to improve patient safety and outcomes.

F41 Liver and Kidney 2: Hepatic Support (A)Technical considerations, practical application and results of different methodsof hepatic support for patients with hepatic failure and hepatorenal syndrome.

G42 Biomarkers 2 (A)Applications for biomarkers as diagnostics and theranostics in AKI and crtitical illness.

5:30 Adjourn

FRIDAY AFTERNOON, MARCH 9

PROGRAM

5:30-7:00 Meet the Faculty Reception

7:25-7:30 Announcements

7:30-10:00 Plenary 4MINI-SYMPOSIAChallenges and Controversies in Renal Support and CRRT

7:30-7:50 Ultrafiltration for Heart Failure: What is the Evidence?Gianacarlo Marenzi, MD

7:50-8:10 Dose of Dialysis in CRRT: Resultsof a Randomized Controlled TrialAshita Tolwani, MD

8:10-8:30 Advances in Renal Support: Literature Review Noel Gibney, MD

8:30-8:45 Fluid Balance Errors with CRRTMachines: Should We Have Standards?Claudio Ronco, MD

8:45-9:00 Applying Pharmacodynamic Principles to CRRT PatientsBruce Mueller, PharmD, FCCP


9:15-9:45 SPECIAL LECTUREDebateContrast Nephropathy: To Filter or Not?James Tumlin, MDGianacarlo Marenzi, MD



10:20-12:50 Plenary 5 MINI SYMPOSIAEmerging Strategies in Extracorporeal Support

10:20-10:40 Wearable Kidney: Does it Exist?Claudio Ronco, MD

10:40-11:00 High Cut Off Membranes: Applications for CancerArthur Bradwell, MD

11:00-11:20 Diffusive Clearance of Cytokines in Sepsis? Fact or Fantasy?Ian Baldwin, RN MN ACCCN

11:20-11:35 High Volume or High Permeability Membranes forSepsis: Which Technique? Patrick Honoré, MD

11:35-11:50 Liver Support Systems: Ready for Prime Time?Stefan Herget-Rosenthal, MD


12:05-12:35 SPECIAL LECTURELooking to the Future: Applying Systems Biology to Extracorporeal SupportJohn Kellum, MD, FACP


12:50 Closing Remarks Ravindra L. Mehta, MD, FACPChairman

12:55 Conference Adjourns

SATURDAY MORNING, MARCH 10

PROGRAM

SESSION III: TECHNIQUE CHARACTERISTICS

SESSION IV: FUTURE TRENDS IN CRRT AND CRITICAL CARE


SATURDAY AFTERNOON, MARCH 10

PROGRAM

ELECTIVE HANDS-ON WORKSHOPS

1:00-5:00 Simultaneous Elective Hands-On Workshops

12:45-1:45 Lunch Hosted by Conference for Workshop Participants

1:45-3:15 SESSION 1

HO2 Fresenius Workshop “SLED , EDD and CRRT with the K Machines”Learn how to us the Fresenius system for CRRT, SLED and EDDChristian Schlaeper, MS

HO3 Baxter & Edwards Critical Care Nephrology Alliance: Accura and Aquarius Hands On SessionTake advantage of an opportunity to work directly with an Accura or Aquarius to better understand the flexibility of these machines and the benefits they can offer. Focus areas are: machine set up, priming, programming and managing a treatment.Lee Ware, RN and Bev Ryan, RN

HO4 CHF Solutions “The Aquadex FlexFlow System”Use of Aquapheresis and the Aquadex FlexFlow in fluid overload states.TBN

HO5 Pediatric Hands-on WorkshopHow to prescribe and deliver CRRT for neonates and pediatric patients, including machineset up, operations, monitoring and managing alarm conditionsTBN


3:30-5:00 SESSION 2

5:00 Workshops Adjourn

DEADLINE FOR RECEIPT OF ABSTRACTS: December 11, 2006

Abstract Submission Via Our Website Is Required(please refer to the website for rules and submission form)

www.crrtonline.com

GENERAL INFORMATION1. The abstract must be written in English.2. Deadline: abstracts MUST BE RECEIVED no later than December 11, 2006.3. Online abstract submissions are required. See website for details: www.crrtonline.com4. Presenting authors must pay the registration fee. Authors of accepted abstracts are not

provided with travel funds.5. All accepted abstracts for poster presentation will be included on the CRRT Conference

multi-media CD that is distributed at the meeting.6. All accepted abstracts will be exhibited during the conference in the poster session.

CONTENT OF THE ABSTRACT1. Abstracts are limited to 350 words.2. Body of abstract: purpose of the study, methods used, summary of the results and

conclusion reached.3. Please try to limit your author list to 10.4. References and credits MUST NOT be included in the abstract.5. Simple tables, figures and graphs may be included, but avoid the use of special characters.6. Formulas should be avoided.7. Use standard abbreviations in parentheses after the full word appears the first time.8. Please indicate the subject category your abstract most closely represents:

a) Patient Characteristics; b) Emerging Concepts in ARF and CRRT; c) Technique Characteristics; d) Targeted Intervention With CRRT.

9. Abstracts will be published as submitted. Proof and edit your submission accordingly.

SUBMISSION1. Notification of acceptance will be mailed by January 5, 2007.2. Upon acceptance, additional information will be forthcoming regarding poster dimensions,

preparation and presentation of your poster.3. For additional information or if you are unable to complete an online submission contact:

RES Seminars Phone: 858-272-1018 Website: crrtronline.com4425 Cass Street, Suite A Fax: 858-272-7687San Diego, CA 92109 USA Email: [email protected]

ABSTRACT INFORMATION

CONFERENCE REGISTRATION FORM

Registration may be completed online at: www.crrtonline.com

Last Name __________________________________________________________________(M.D.) (Ph.D.) (R.N.) (Other)

First Name_______________________________________________ Middle Initial______

Address____________________________________________________________________

City___________________________ State________ Zip____________ Country_________

Telephone: (______)________________________ Fax: (______)_____________________(Please include country and city codes)

Email: _____________________________________________________________________

Affiliation:__________________________________________________________________

Specialty or Area of Practice: ___________________________________________________(Int Med) (Neph) (Crit Care) (Ped) (Surg) (Anest) (Other)

REGISTRATION FEES Early Bird Pre-Registration RegistrationOn or before January 12 thru March 5 thru

January 11, 2007 March 4, 2007 March 10, 2007On-Site

Registrants (M.D., Ph.D., etc.) ❏ $ 595 ❏ $ 665 ❏ $ 730

Nurses/Dieticians/IndustryPharmacists/Residents*/Fellows* ❏ $ 405 ❏ $ 475 ❏ $ 540*requires letter of verification from dept. head

Total Registration Fees: _________Fee Includes: Access to general sessions, conference workshops (Thurs-Fri) Exhibit area, Receptions onThursday & Friday and Lunches on Thursday & Friday. Does not include Elective Hands-On Workshops.

ELECTIVE HANDS-ON WORKSHOPS see back of this form for selection and descriptions

Wednesday, March 7 - 9:00am-4:30pm (6 hours + lunch) $125 x ____ = _________Saturday, March 10 - 1:00-5:00pm (3 hours + lunch) $ 75 x ____ = _________

Total Elective Hands-On Workshop Fees: _________

GUEST FEEIncludes access to Exhibit Area, Receptions on Thurs. & $150 x ____ = _________Fri., Lunch on Thurs. & Fri. (Guests are not admitted to the General Sessions or Workshops) Total Guest Fees: _________

ELECTIVE ACTIVITY FEES (see “General Information” for details)

Coronado Walking Tour Adults $12 x ____ = _________Thursday, March 8th (10:45am-12:30pm) Children $12 x ____ = _________

San Diego Trolley Car Tour Adults $30 x ____ = _________Friday, March 9th (9:30am-11:30am) Children $14 x ____ = _________

Total Elective Activity Fees: _________

TOTAL FEES: _________

TWELFTH INTERNATIONAL CRRT CONFERENCE MARCH 7-10, 2007

Please complete payment information and workshopselection on the back of this registration form

CONFERENCE FEES AND PAYMENTPlease complete this section with total fees for Registration, Hands-on Workshops, Guest and Elective Activities

PAYMENT BY CHECK:U.S. FUNDS, DRAWN ON A U.S. BANK Payable to: San Diego CRRT Conference

CREDIT CARD PAYMENT: (only) ❏ VISA OR ❏ MASTERCARD

Card Number_________________________________________

Expiration Date___________/___________/__________

Name on Card________________________________________

Signature____________________________________________

CONFERENCE REGISTRATION FORM

WORKSHOP SELECTIONPlease select Workshops from the list on the next page.

Every attempt will be made to assign you your choices, but the assignments will be made on avail-ability at the time your registration is received. Please indicate a 2nd choice for each Workshop Group.

Pre-registration for workshops is required. We recommend using the conference websitefor workshop selection and conference registration: www.crrtonline.com

WORKSHOP Group 1 - Thur. 8:00-9:30am

1st choice 2nd choice

WORKSHOP Group 2 - Thur. 9:45-11:15am


WORKSHOP Group 3 - Thur. 12:45-2:15pm


WORKSHOP Group 4 - Thur. 2:30-4:00pm


WORKSHOP Group 5 - Fri. 2:15-3:45pm


WORKSHOP Group 6 - Fri. 4:00-5:30pm


month / date / year

MAIL or FAX TO:CRRT ConferenceRES Seminars4425 Cass Street, Suite ASan Diego, CA 92109 USAFax: 858-272-7687

TOTAL FEES: $___________

ELECTIVE HANDS-ON WORKSHOPS Optional (fee required)Workshops are “hands-on” and require a limited number of participants. Admission is based on a “firstcome first serve” for those delegates who select desired workshop and make payment. Register early!

Wednesday March 7th (9:00am – 4:30pm) Fee: $125 Includes lunch & breaks

❏ HO1 Gambro Prismaflex Hands-On Workshop

Saturday March 10th (1:00pm – 5:00pm) Fee: $75 Includes lunch & breakThe Four (4) workshops on Saturday are concurrent, choose one (1) from the list below

❏ HO2 Fresenius: SLED , EDD and CRRT with the K machines

❏ HO3 Baxter & Edwards Critical Care Nephrology Alliance: Accura & Aquarius Hands On Session

❏ HO4 CHF Solutions “The Aquadex FlexFlow System”

❏ HO5 Pediatric Hands-on WorkshopSee General Information page

for more workshop information

WORKSHOP SELECTION

WORKSHOP Group 1 Thursday 8:00-9:30amCode TitleA01 CRRT Systems I (C,N,AP)B02 Dialysis Dose Prescription and

Delivery 1 (C,N)C03 Vascular Access /Membrane and

Circuit 1 (C,N,AP)D04 Resuscitation 1 (C,N,AP)E05 Pediatric CRRT: The Basics (I,N,AP)F06 Extracorporeal Techniques for Sepsis 1(A) G07 Plasma Exchange Therapy and

Hybrid Techniques 1 (A)

WORKSHOP Group 2 Thursday 9:45-11:15am Code TitleA08 CRRT Systems II (C,N,AP)B09 Anticoagulation 1: Mechanisms & Tech.(C)C10 Fluid Management 1 (I,N,AP)D11 Acid Base and Electrolyte Problesm in

the Critically Ill 1 (I,N,AP)E12 Organizational Aspects of

CRRT Programs 1 (C,N,AP)F13 Heart Failure & Cardio-Renal Syndrome1 (I) G14 Therapy Comparisons I:

SLED vs. CRRT vs. PD (I,N,AP)

WORKSHOP Group 3 Thursday 12:45-2:15pm Code TitleA15 CRRT Systems III (C,N,AP)B16 Solutions for CRRT 1 (I,N)C17 Drug Management 1 (I,N,AP)D18 Nutritional Assessment and Support 1 (I,N)E19 A Systems-based Approach to

CRRT 1 (A,N,AP)F20 Liver and the Kidney 1 (A)G21 Biomarkers 1 (I,N)

WORKSHOP Group 4 Thursday pm 2:30-4:00pmCode TitleA22 CRRT Systems I (C,N,AP)B23 Dialysis Dose Prescription and

Delivery 2 (I)C24 Vascular Access/Membrane and

Circuit 2 (C,N,AP)D25 Resuscitation 2 (A,N,AP)E26 CRRT in the New Born (I,N,AP)F27 Extracorporeal Techniques for Sepsis 2 (A)G28 Plasma Exchange Therapy and

Hybrid Techniques 2 (A)

WORKSHOP Group 5 Friday 2:15-3:45pm Code TitleA29 CRRT Systems II (C,N,AP)B30 Anticoagulation 2: Special Tech. Citrate (A)C31 Fluid Management 2 (I,N,AP)D32 Acid Base and Electrolyte Problems in

the Critically Ill 2 (A)E33 Organizational Aspects of

CRRT Programs 2 (C,N,AP)F34 Heart Failure and Cardio-renal Syndrome 2 (A)G35 Therapy Comparisons 2:

SLED vs. CRRT vs. PD (A)

WORKSHOP Group 6 Friday 4:00-5:30pm Code TitleA36 CRRT Systems III (C,N,AP)B37 Solutions for CRRT 2 (A)C38 Drug Management 2 (I,N)D39 Nutritional Assessment and Support 2 (I)E40 A Systems-based Approach to

CRRT 2 (A,N,AP)F41 Liver and Kidney II: Hepatic Support (A)G42 Biomarkers 2 (A)

Codes C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = (of interest to nurses and allied personnel)

A 0 1Example

WORKSHOP SELECTION

The workshops are designed for small group interaction on specific topics. Workshopsmarked with an asterisk (*) will be presented twice and will include course material.Workshop presented in a series are marked with a “1” or “2.”

Please use the Workshop codes listed below to complete your registration form. Every attemptwill be made to assign you your choices, but the assignments will be made on availability at thetime your registration is received. Please indicate a 2nd choice for each Workshop Group.

Directions to the Hotel del Coronado from San Diego Lindbergh International Airport

• Exit the airport and by turning left onto N. Harbor Dr.• Travel approximately 1.4 miles and then turn left onto W. Grape St.• Travel approximately 1/2 mile and look for the Interstate 5 south on-ramp (far right lane)• Merge onto Interstate 5 freeway traveling south• Travel approximately 3 miles (through Downtown San Diego) until you see the

California 75 - Coronado Bay Bridge exit (far right lane).• Merge onto California 75 Coronado Bay Bridge.• After driving over Coronado Bay Bridge, stay to the left on 3rd Street.• Travel approximately .10 mile on 3rd and turn left onto Orange Ave.• Follow Orange Ave. approximately 2 miles to the Hotel del Coronado.• The resort main entrance is just past R. H. Dana Place to the right.

MAP AND DIRECTIONS

Twelfth International Conference on Continuous Renal Replacement Therapies (CRRT)March 7-10, 2007

MAIL or FAX THIS RESERVATION FORM DIRECTLY TO HOTEL

Or visit the conference website to make hotel reservations online: www.crrtonline.com

HOTEL RESERVATION DEADLINE: February 1, 2007

Name ______________________________________________________________Last First Middle Initial

Address_____________________________________________________________

City_________________________State____________Country_________________

Telephone: (____)_____________________Fax (______)____________________(Please include country and city codes)

Arrival Date:_____________Time:______________Departure Date:____________

❏ Single ❏ Double ❏ Smoking ❏ Non Smoking Check-in 4:00 pm Check-out 12:00 noon

First night’s deposit or credit card guarantee must accompany reservation.

Credit Card__________Exp. Date________Card#___________________________

Name on Card_______________________________________________________

Signature____________________________________________________________

$255 per night single or double occupancy for Victorian rooms ($255 plus 8% occupancy tax, plus $16 resort fee)

$285 per night single or double occupancy for Resort rooms ($285 plus 8% occupancy tax, plus $16 resort fee)

HOTEL RESERVATION FORM

LOCATION AND ACCOMMODATIONSHOTEL del CORONADO

Visit the conference website to make hotel reservations online: www.crrtonline.com

The course is being held at the Hotel del Coronado, 1500 Orange Avenue, Coronado, CA 92118. Thehotel, located on Coronado Island (just a few minutes drive across the Coronado Bay Bridge fromDowntown San Diego), is set on one of the most beautiful beaches in California. Available recre-ational facilities include a beautiful olympic size outdoor swimming pool; full health spa, exerciseroom, sauna, and jacuzzi; and ocean-side walking and biking paths. The Coronado Golf Course,which overlooks the bay, is just minutes from the Del. Both gourmet and causal dining facilities andmany specialty shops are available within the hotel. Coronado is just a short drive from Sea World,the San Diego Zoo, Balboa Park, Old Town, the Wild Animal Park and Mexico.

March is tourist season in San Diego and the Del is one of its most popular resorts. If you plan tostay there, be sure to get your reservations in early. A limited number of rooms have been reservedfor course participants and will be available on a first come, first serve basis. Rooms must bereserved by February 1, 2007. Please fax the reservation form below to 619-522-8238, or call1-800-468-3533. Please specify you are attending the CONTINUOUS RENAL REPLACEMENTCONFERENCE (CRRT) so you can receive our special course rates.

Hotel del Coronado1500 Orange AvenueCoronado, CA 92118

Reservations: 1-800-Hotel-delFax: 619-522-8238 Web Info: www.hoteldel.com

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