dean hartley: alzheimer’s association research initiatives
DESCRIPTION
Down Syndrome-Alzheimer's Disease Panel Presentation at Global Down Syndrome Foundation Research & Medical Care Roundtable on Thursday, July 18, 2013, at Children's Hospital Colorado. Dean Hartley, PhD, is Director of Science Initiatives, Medical and Scientific Relations, Alzheimer’s AssociationTRANSCRIPT
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Alzheimers Association Research Initiatives
Dean M. Hartley, Ph.D. Director of Scientific Director
Alzheimers Association
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Our vision is a world without Alzheimers disease
Our goals: Advance research Provide care
and support Increase Concern &
Awareness Public Policy &
Advocacy Efforts
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Alzheimers Association is the global leader in Alzheimer research.
Amyloid Imaging Taskforce (AIT)
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A New Research Ini/a/ve Down Syndrome & Alzheimers disease
ALZHEIMERS ASSOCIATION, LINDA CRNIC INSTITUTE FOR DOWN SYNDROME, AND GLOBAL DOWN SYNDROME
FOUNDATION LAUNCH NEW RESEARCH GRANTS PROGRAM
Initial $1.2 million aims to fund research to better treat Alzheimers in people with Down syndrome and the
general population
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The challenge began 100 years ago November 1906: Alois Alzheimer
presented first case in Germany 51-year-old Auguste D. had
profound memory loss, confusion, language difficulty, unfounded suspicions about husband and hospital staff
Her young age made Alzheimer think Auguste had a rare disease associated with middle age
tangles
plaques
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Normal Alzheimers disease
Continuum of Alzheimers Disease
Adapted from Sperling et al. 2011
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The Dominantly Inherited Alzheimer Network (DIAN) Observational Trial
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1.2
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Muta/on Carriers
Non-Carriers
Logical Memory Beta-Amyloid Deposition
Est. Years Before Clinical Onset Est. Years Before Clinical Onset
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10
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Muta/on Carriers
Non-Carriers
Bateman et al. (2012) N Eng J Med 367: 795- 804
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DIAN-Trial Unit Alzheimers Association help to initiate the
trial: $4.2M grant Three simultaneous trials to test potential
therapies: Gantenerumab (Roche, Monoclonal antibody to AB) Solaneuzumab (Lilly, Monoclonal antibody to AB) TBD
Adaptive Trial Design Condenses the timeline Trial began March, 2013
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Genetic Links to Alzheimers and Down Syndrome
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NATURE REVIEWS | DRUG DISCOVERY VOLUME 11 | SEPTEMBER 2012 | 655