david william busija, m.a., ph.d., m.d. (hon)€¦ · stroke in stroke-prone spontaneously...

David William Busija, M.A., Ph.D., M.D. (Hon)

Regents Endowed Professor and Chairman Department of Pharmacology, Tulane University School of Medicine

ADDRESS: 1430 Tulane Avenue, SL 83

New Orleans, LA 70112 Phone: 504-988-2628 E-Mail: [email protected]

EDUCATION/DEGREES: 1968-1972 University of Pittsburgh, Pittsburgh, Pennsylvania

B.S., Cum Laude, Psychology and Anthropology 1972-1974 University of Kansas, Lawrence, Kansas

M.A., with Departmental Honors, Physical Anthropology 1974-1978 University of Kansas, Lawrence, Kansas

Ph.D., Phi Kappa Phi, Physiology 2009 University of Szeged Medical School (formerly Albert Szent-Györgyi

Medical School), Hungary Doctorem Medicinae Honoris Causa [M.D. (Hon)]

POSTDOCTORAL TRAINING:

6/78-6/81 The Cardiovascular Center, College of Medicine University of Iowa, Iowa City, Iowa Advisor: Dr. Donald Heistad NIH Postdoctoral Fellowship, 1978-81

ACADEMIC APPOINTMENTS:

7/81-7/82 Assistant Professor; Chair, Dr. Richard Traystman Department of Anesthesiology/Critical Care Medicine Johns Hopkins University Baltimore, Maryland 8/82-6/87 Assistant Professor, 7/87-9/90 Associate Professor (with tenure); Chair, Dr. Leonard Share Department of Physiology and Biophysics The University of Tennessee, Memphis Memphis, Tennessee 9/90-1992 Associate Professor, 1992-2010 Professor (with tenure); Chair, Dr. James Smith Department of Physiology and Pharmacology Wake Forest University School of Medicine Winston-Salem, North Carolina 2006-2010 Adjunct Professor; Institute Director, Dr. Anthony Atala Institute for Regenerative Medicine Wake Forest University School of Medicine Winston-Salem, North Carolina 2011-present Professor Emeritus; Chair, Dr. Linda Porrino Department of Physiology and Pharmacology Wake Forest University School of Medicine Winston-Salem, North Carolina 2011-present Regents Professor and Chairman Department of Pharmacology

BUSIJA, DAVID W., PH.D. CURRICULUM VITAE PAGE 2

(Revised 1/11/16)

Tulane University School of Medicine New Orleans, Louisiana

NIH Study Sections and other grant review committees

1990-present Ad hoc and Special Study Section Reviewer for various NIH Institutes including NINDS and NHLBI, Veteran’s Administration, March of Dimes, AHA, ALS, NSF, etc., as well as for several foreign entities including the National Science Fund of Hungary (OTKA).

2010 Chair, NIH Special Emphasis Review Panel 1999-2004 NIH Study Section, Regular Member, Experimental Cardiovascular

Sciences 2007-2011 NIH Study Section, Regular Member, Vascular Cell and Molecular Biology

Editorial Boards/Reviewer

1991-1993/1995-2000, 2006-2012 2014-present Editorial Board, American Journal of Physiology; Heart & Circulatory

Physiology 2010-present Editorial Board, Microcirculation 2010-2012 Editorial Board, Journal of Cerebral Blood Flow and Metabolism 1992-2000 Editorial Board, Stroke Continuous Reviewer for American Journal of Physiology subsections, Brain Research, Circulation Research, Pediatric Research, Journal of Neurochemistry, Circulation, Stroke, Journal of Neuroscience, and many other journals.

Consultancies Continuous Law firms and medical schools/hospitals

INSTITUTIONAL SERVICE:

UNIVERSITY OF TENNESSEE (1982-1990): Faculty Senate, Executive Committee; Member of Scientific Authorship Committee;

Departmental Seminar Committee; Departmental Recruitment Committee, UT Drug Free Workplace Task Force; University Curriculum Review Committee (Chairman of 2 subcommittees); and participant in many other committees.

WAKE FOREST UNIVERSITY HEALTH SCIENCES (1990-2010): Course Director for Medical Physiology; Member of Animal Care & Use Committee, Head of Cardiovascular Round Table; Member of Medical Student Promotions Committee, Member and chair of numerous preliminary examination and dissertation committees; Chair and member of evaluating committees for new faculty candidates; Scientific Misconduct Advisory Committee to the Dean; Co-Director of Cardiovascular Sciences Training Grant; Budget and Research Offices Committee; Appointments and Promotion Committee; Member of strategic planning Committee, subsection chair; Member of student recruitment Committee; Chair of Junior Faculty Mentorship Committees; and participant in many other committees. TEACHING: In addition to serving as course director or section leader, and having introduced several teaching innovations to curricula, I have taught in Pharmacology, Physiology, Anatomy, Neuroscience, Physical Anthropology, and Biochemistry courses


(Revised 1/11/16)

directed to Graduate, Medical, Pharmacy, Physical and Occupational Therapy, Nursing, Dental, and Undergraduate students. TULANE UNIVERSITY SCHOOL OF MEDICINE (2011- PRESENT): Head of the Basic Science Department Chairs’ Committee Member of Executive Council PROFESSIONAL MEMBERSHIPS AND SERVICE:

1981 International Society for Cerebral Blood Flow and Metabolism (Founding member) 1983 American Physiology Society (APS) 1983 American Association for the Advancement of Science 1991 Society for Neuroscience 1992 American Heart Association, Stroke Council 2004 British Pharmacological Society 2010 American Society for Pharmacology and Experimental Therapeutics 2012 Association of Medical School Pharmacology Chairs

Special committees related to membership in National and International Professional Societies 1994-1995 Program Committee, Winter Conference on Brain Research 2001-2006 Cardiovascular Section Representative of APS, and APS representative to

Joint Program Committee for yearly Experimental Biology Meetings 2003-2005 APS advisor to International Union of Physiological Society Program Committee 2004-2008 Cardiovascular Section (APS) Training Committee 2006-2009 APS Committee on Committees 2004-2014 Cardiovascular Section (APS) Steering Committee Member

2011-2014 Secretary/Treasurer of Cardiovascular Section of the American Physiological Society

2014-present Treasurer of Association of Medical School Pharmacology Chairs HONORS AND AWARDS: Awards 1981-1984 NIH New Investigatorship Award 1990 Elected Fellow of Cardiovascular Section of American Physiological Society 2002-2005 Bugher Foundation Award for Stroke Research from AHA 2004 Distinguished Lectureship, Korean Physiological Society 2005 95th percentile (top 5%) of the distribution of extramural NIH grants over the last 25 years (inflation corrected direct and indirect costs, not including program project or center grants) 2006 Endowment Support from Y. F. Wu Research and Education Fund, WFUHS

Venture Fund, and K. G. Phillips Fund for Prevention and Treatment of Heart Disease

2005 Research Excellence Award 2009 Doctorem Medicinae Honoris Causa The University of Szeged, Hungary 2011 Louisiana Board of Reagents Endowed Professorship


(Revised 1/11/16)

2014 Distinguished Invited Lecturer, University of California—Los Angeles PROFESSIONAL INTERESTS: Human Evolution and Diversity, Innovative Teaching Approaches, Mentoring of Junior Faculty GRANTS: CURRENT AND PENDING:

A. ACTIVE: Principal Investigator:

NIH Individual Research Grant (David Busija, PI), HL093554, 4/1/09- 8/31/18, “Mitochondrial influences on cerebral arteries,” 20% effort. Lousiana Board of Regents Endowed Professorship, 1/1/11-12/31/15.

B. PAST GRANT HISTORY: NIH Individual Research Grant (David Busija, PI) HL-077731, (original start date—9/04), 1/15/10-2/28/15, “Potassium channel Dysfunction in Cerebral Arteries,” 20% effort. NIH Individual Research Grant (David Busija, PI) HL-065380, (original start date – 4/02), 5/01/06-4/30/15, $1,092,375 (Direct costs for 5 years),”Endothelial Dysfunction in Insulin Resistance,” 20% effort. NIH Individual Research Grant (David Busija, PI) HL-030260, (original start date - 8/82) 03/01/06-08/29/12, $1,213,700 (Direct costs for 5 years), “Regulation of Cerebral Blood Flow,” 20% effort.

Hungarian Ministry of Education and Culture International Cooperative Grant TÁMOP-4.2.2., (Botond Penke, PI; David W. Busija, et al., Co-PIs), 7/1/09-6/30/12, Costs are salary and travel support for joint studies (for example, travel and 1 month living expenses in either Hungary or USA), “Investigations of the pathomechanisms and therapeutic possibilities of neurodegenerative diseases, anxiety and depression.”

WFUBMC Translational Science Institute (David Busija, Co-PI) 1/01/08-12/31/08, $125,000 (Direct costs for 1 year), “The TEVA Study: Tissue Engineering of Vascular Access,” 5% effort. AstraZeneca LP, Grant-In-Aid (David Busija, PI), 3/1/05-2/28/06, $49,660 (Direct costs), “Examination of Direct Effects of Rosuvastatin on Production of Reactive Oxygen Species by Cerebral Arteries in Insulin Resistance.” NIH Individual Research Grant (David Busija, PI) DK-62372, 8/1/02-7/31/05, $650,000 (Direct costs for 3 years), “Cerebrovascular dysfunction in insulin resistance.” AHA Bugher Stroke Award (David Busija, PI) AHA-0270114N, 1/1/02-12/31/05, $360,000 (Direct costs for 4 years), “Effects of insulin resistance on the cerebral circulation.” North Carolina Biotechology Center Equipment Grant (David Busija, PI), 7/15/02-7/14/04, $186,875 (Direct costs), “Simultaneous Patch Clamp Confocal Imaging System for


(Revised 1/11/16)

Enhancing Cardiovascular Research and Training at Wake Forest University School of Medicine” NIH Individual Research Grant (David Busija, PI) HL-66074, 4/1/01-3/31/04, $475,000 (Direct costs), “Impaired Coronary Artery Function In Insulin Resistance” AHA Mid-America Grant-in-Aid (David Busija, PI), 2000-2001, “Cyclooxygenase-2 in vascular endothelial hypoxia” NIH Individual Research Grant (David Busija, PI), 1994-2001, “Oxytocinergic effects on cerebral hemodynamics” NIH Individual Research Grant (David Busija, PI), 1991-2003, “Vascular responses during cortical spreading depression” NIH New Investigator Award (David Busija, PI), 1983-1986, “Control of Cerebral Hemodynamics”

PATENTS: Received: U.S Patent No. 6,313,112B1; Issue Date: 11-6-01 “Methods of protecting neuronal function” Serial No.:09/694,121. GENE DISCOVERY: Cyclooxygenase Variant Protein GenBank AY523672, AY523673, AY547265 BIBLIOGRAPHY Dr. Busija has a calculated H Index rating of 55.

Publications 1. Orr JA, Busija DW. Isocapnic hyperpnea in awake ponies during inspiration of 4%

CO2. J Appl Physiol 1979; 47:445-452.

2. Busija DW. Human Physiology 300. Lawrence, Kansas: Extramural Independent Study Center, 1979.

3. Busija DW, Orr JA, Rankin JHG, Liang HG, Wagerle LC. Cerebral blood flow during normocapnic hyperoxia in the unanesthetized pony. J Appl Physiol 1980; 48:10-15.

4. Busija DW, Heistad DD, Marcus ML. Effects of sympathetic nerves on cerebral vessels during acute, moderate increases in arterial pressure in dogs and cats. Circ Res 1980; 46:696-702.

5. Busija DW, Heistad DD. Effects of cholinergic nerves on cerebral blood flow in cats. Circ Res 1980; 48:62-69. Heistad DD, Marcus ML, Busija DW. Measurement of cerebral blood flow in experimental animals with microspheres: application of the method. In: JV Passonneau JV et al., eds. Cerebral metabolism and neural function. Baltimore: Williams and Wilkins, 1980:202-211.


(Revised 1/11/16)

6. Heistad DD, Gross PM, Busija DW, Marcus ML. Cerebral vascular responses to loading and unloading of arterial baroreceptors. In: Sleight P, ed. Arterial baroreceptors and hypertension. Oxford: Oxford Press, 1980:210-217.

7. Sadoshima S, Busija DW, Heistad DD, Brody MJ. Sympathetic nerves protect against stroke in stroke-prone spontaneously hypertensive rats. Hypertension 1981; 3:I124-I127.

8. Heistad DD, Marcus ML, Gourley JK, Busija DW. Effect of adenosine and dipyridamole on cerebral blood flow. Am J Physiol 1981; 240:H775-H780.

9. Busija DW, Heistad DD, Marcus ML. Continuous measurement of cerebral blood flow in anesthetized cats and dogs. Am J Physiol 1981; 241:H228-H234.

10. Heistad DD, Marcus ML, Busija DW. Effects of acetylcholine, VIP and adenosine on cerebral blood flow. In: Vanhoutte PM, Leusen I, eds. Vasodilation. New York: Raven Press, 1981:73-83.

11. Heistad DD, Busija DW, Marcus ML. Neural effects on cerebral vessels: alteration of pressure-flow relationship. Fed Proc 1981; 40:0213-0217.

12. Marcus ML, Busija DW, Bischof CJ, Heistad DD. Methods for measurement of cerebral blood flow. Fed Proc 1981; 40:2306-2310.

13. Busija DW, Heistad DD. Atropine does not attenuate cerebral vasodilation during hypercapnia. Am J Physiol 1982; 242:H683-H687.

14. Busija DW, Marcus ML, Heistad DD. Pial artery diameter and blood flow velocity during sympathetic stimulation in cats. J Cereb Blood Flow Metab 1982; 2:363-367.

15. Busija DW, Sadoshima S, Marcus ML, Heistad DD. Functional significance of sympathetic innervation of cerebral vessels. Can the issue now be resolved? In: Kalsner S, ed. Trends in autonomic pharmacology. Baltimore: Urban and Schwarzenberg, 1982:187-204.

16. Busija DW, Marcus ML, Heistad DD. Effects of sympathetic nerves on the cerebral circulation in cats. In: Heistad DD, Marcus ML, eds. Cerebral blood flow: effect of nerves and neurotransmitters. New York: Elsevier, 1982:301-308.

17. Sadoshima S, Busija DW, Brody M, Heistad DD. Protection against stroke by sympathetic nerves. In: Heistad DD, Marcus ML, eds. Cerebral blood flow: effect of nerves and neurotransmitters. New York: Elsevier, 1982:309-316.

18. Heistad DD, Marcus ML, Busija DW, Sadoshima S. Protective effects of sympathetic nerves in the cerebral circulation. In: Heistad DD, Marcus ML, eds. Cerebral blood flow: effect of nerves and neurotransmitters. New York: Elsevier, 1982:267-275.

19. Marcus ML, Busija DW, Gross PM, Brooks LA, Heistad DD. Sympathetic escape in the cerebral circulation during normotension and acute severe hypertension. In: Heistad DD, Marcus ML, eds. Cerebral blood flow: effect of nerves and neurotransmitters. New York: Elsevier, 1982:281-290.

20. Busija DW, Heistad DD. Effects of indomethacin on cerebral blood flow during hypercapnia in cats. Am J Physiol 1983; 244:H519-H524.


(Revised 1/11/16)

21. Sadoshima S, Busija DW, Heistad DD. Mechanisms of neural protection against stroke in stroke-prone spontaneously hypertensive rats. Am J Physiol 1983; 244:H406-H412.

22. Busija DW. The role of prostaglandins in the response of the cerebral circulation to carbon dioxide in conscious rabbits. J Cereb Blood Flow Metab 1983; 3:376-380.

23. Busija DW, Heistad DD. Effects of activation of sympathetic nerves on cerebral blood flow during hypercapnia in cats and rabbits. J Physiol (Lond) 1984; 347:35-45.

24. Busija DW. Sympathetic nerves reduce cerebral blood flow during hypoxia in awake rabbits. Am J Physiol 1984; 247:H446-H451.

25. Busija DW. Hypercapnia potentiates renal vasoconstriction during hemorrhagic hypotension in awake rabbits. Am J Physiol 1984; 246:H671-H674.

26. Busija DW, Heistad DD. Factors involved in physiological regulation of cerebral blood flow. Rev Physiol Pharmacol Biochem 1984; 101:161-211.

27. Busija DW. Interaction between hemorrhagic hypotension and hypoxia in regulation of renal vascular resistance in unanesthetized rabbits. Circ Shock 1984; 13:353-359. Baumbach G, Busija DW, Werber A, Heistad DD. Role of autonomic innervation in modification of cerebral vascular responses. In: Mackenzie E, Seylaz J, Bes A, eds. Neurotransmitters and the cerebral circulation. New York: Raven Press, 1984:53-64.

28. Busija DW. Role of prostaglandins in modulating sympathetic vasoconstriction in the cerebral circulation in anesthetized rabbits. J Cereb Blood Flow Metab 1985; 5:17-25.

29. Proctor KG, Busija DW. Relationship between arteriolar, regional, and whole organ blood flow in the rat cremaster muscle. Am J Physiol 1985; 249:H34-H41.

30. Busija DW, Leffler CW, Wagerle LC. Responses of newborn pig pial arteries to sympathetic nervous stimulation and exogenous norepinephrine. Ped Res 1985; 19:1210-1214.

31. Busija DW. Sustained cerebral vasoconstriction during bilateral sympathetic stimulation in anesthetized rabbits. Brain Res 1985; 345:341-344.

32. Busija DW. Indomethacin does not potentiate renovascular constriction during hypercapnia in unanesthetized rabbits. Prostaglandins 1985; 30:229-240.

33. Leffler CW, Busija DW, Fletcher AM, Beasley DG, Hessler JR, Green RS. Effects of indomethacin upon cerebral hemodynamics of newborn pigs. Ped Res 1985; 19:1160-1164.

34. Leffler CW, Busija DW. Prostanoids in cortical subarachnoid cerebrospinal fluid and pial arterial diameter In newborn pigs. Circ Res 1985; 57:689-694.

35. Leffler CW, Busija DW. Arachidonate metabolism on the cerebral surface of newborn pigs. Prostaglandins 1985; 30:811-817.

36. Blatteis CM, Hunter WS, Busija DW, Llanos-Q J, Ahokas RA, Mashburn TA Jr. Thermoregulatory and acute-phase responses to endotoxin of term-pregnant rabbits. J Appl Physiol 1986; 60:1578-1583.

37. Busija DW. Unilateral and bilateral sympathetic effects on cerebral blood flow during normocapnia. Am J Physiol 1986; 19:H498-H502.


(Revised 1/11/16)

38. Busija DW, Leffler CW. Post-junctional α2-adrenoreceptors in pial arteries of newborn pigs. Dev Pharmacol Ther 1987; 10:36-46.

39. Leffler CW, Busija DW, Beasley DG, Fletcher AM, Green RS. Effects of indomethacin on cardiac output distribution in normal and asphyxiated piglets. Prostaglandins 1986; 31:183-190.

40. Busija DW, Leffler CW, Beasley DG. Effects of leukotrienes C4, D4, and E4 on cerebral arteries of newborn pigs. Ped Res 1986; 20:973-976.

41. Busija DW, Leffler CW. Eicosanoid synthesis elicited by norepinephrine in piglet parietal cortex. Brain Res 1987; 403:243-248.

42. Busija DW, Leffler CW. Exogenous norepinephrine constricts cerebral arterioles via α2-adrenoceptors in newborn pigs. J Cereb Blood Flow Metab 1987; 7:184-188.

43. Leffler CW, Busija DW, Beasley DG, Fletcher AM. Maintenance of cerebral circulation during hemorrhagic hypotension in newborn pigs: role of prostanoids. Circ Res 1986; 59:562-567.

44. Leffler CW, Busija DW, Brooks DP, Crofton JT, Share L, Beasley DG, Fletcher AM. Vasopressin responses to asphyxia and hemorrhage in newborn pigs. Am J Physiol 1987; 21:R122-R126.

45. Green RS, Leffler CW, Busija DW, Fletcher AM, Beasley DG. Indomethacin does not alter the circulating catecholamine response to asphyxia in the neonatal piglet. Ped Res 1987; 21:534-537.

46. Busija DW, Leffler CW. Leukotrienes increase levels of prostanoids in cerebrospinal fluid in piglets. Prostaglandins 1986; 32:803-812.

47. Leffler CW, Busija DW. Prostanoids and pial arteriolar diameter in hypotensive newborn pigs. Am J Physiol 1987; 252:H687-H691.

48. Leffler CW, Busija DW. Arachidonic acid metabolites and perinatal cerebral hemodynamics. Sem Perinatal 1987; 11:31-42.

49. Bealer S, Busija DW. Redistribution of cardiac output after hypothalamic lesion and hemorrhage. Exp Brain Res 1987; 69:107-112.

50. Busija DW, Leffler CW. Hypothermia reduces cerebral metabolic rate and cerebral blood flow in newborn pigs. Am J Physiol 1987; 22:H869-H873.

51. Leffler CW, Busija DW, Beasley DG. Effect of therapeutic dose of indomethacin in the cerebral circulation of newborn pigs. Ped Res 1987; 21:188-192.

52. Mirro R, Busija DW, Green RS, Leffler CW. The relationship between mean airway pressure, cardiac output, and organ blood flow with normal and decreased respiratory compliance. J Pediatr 1987; 111:101-106.

53. Leffler CW, Busija DW, Share L, Crofton JT, Brooks DP, Beasley DG, Green RS, Mirro R. Adrenergic mediation of vasopressin secretion in newborn pig. Am J Physiol 1987; 22:R489-R493.

54. Mirro R, Armstead WM, Busija DW, Green RS, Leffler CW. Increasing ventilation pressure increases cortical subarachnoid CSF prostanoids in newborn pigs. Ped Res 1987; 22:647-650.


(Revised 1/11/16)

55. Armstead WM, Pourcyrous M, Mirro R, Leffler CW, Busija DW. Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs. Circ Res 1988; 62:1-7.

56. Armstead WM, Mirro R, Leffler CW, Busija DW. The role of prostanoids in the mediation of responses to KC-404, a novel cerebrovasodilator. J Pharmacol Exp Ther 1988; 244:138-143.

57. Busija DW, Wagerle LC, Pourcyrous M, Leffler CW. Acetylcholine dramatically increases prostanoid synthesis in piglet parietal cortex. Brain Res 1988; 439:122-126.

58. Busija DW, Leffler CW, Pourcyrous M. Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigs. Am J Physiol 1988; 24:H343-H346.

59. Mirro R, Busija DW, Armstead WM, Leffler CW. Histamine dilates the pial arterioles of newborn pigs through prostanoid production. Am J Physiol 1988; 23:H1023-H1026.

60. Armstead WM, Leffler CW, Busija DW, Beasley DG, Mirro R. Adrenergic and prostanoid mechanisms in the control of cerebral blood flow in hypotensive newborn pigs. Am J Physiol 1988; 23:H671-H677.

61. Pourcyrous M, Leffler CW, Busija DW. Post-asphyxial increases in prostanoids in cerebrospinal fluid in piglets. Ped Res 1988; 24:229-232.

62. Mirro R, Leffler CW, Armstead WM, Beasley DG, Busija DW. Indomethacin restricts cerebral blood flow during pressure ventilation of newborns. Ped Res 1988; 24:59-62.

63. Armstead WM, Mirro R, Busija DW, Leffler CW. Postischemic generation of superoxide anion by newborn pig brain. Am J Physiol 1988; 24:H401-H403.

64. Lovelady GK, Mirro R, Armstead WM, Busija DW, Leffler CW. Effect of 15-HETE on cerebral arterioles of newborn pigs. Prostaglandins 1988; 36:507-513.

65. Busija DW, Leffler CW. Role of prostanoids in cerebrovascular responses during seizures in piglets. Am J Physiol 1989; 256:H120-H125.

66. Armstead WM, Mirro R, Busija DW, Leffler CW. Vascular responses to vasopressin are tone-dependent in the cerebral circulation of the newborn pig. Circ Res 1989; 64:136-144.

67. Armstead WM, Mirro R, Leffler CW, Busija DW. Acetylcholine produces cerebrovascular constriction through activation of an M-1 mechanism in the newborn pig. J Pharmacol Exp Ther 1989; 247:926-933.

68. Wagerle LC, Busija DW. Cholinergic mechanisms in the cerebral circulation of the newborn piglet: effect of inhibitors of arachidonic acid metabolism. Circ Res 1989; 64:1030-1036.

69. Busija DW, Armstead WM, Leffler CW, Mirro R. Lipoxins A4 and B4 dilate cerebral arterioles of newborn piglets. Am J Physiol 1989; 256:H468-H471.

70. Armstead WM, Mirro R, Leffler CW, Busija DW. Cerebral superoxide anion generation during seizure in newborn pigs. J Cereb Blood Flow Metab 1989; 9:175-179.

71. Leffler CW, Busija DW, Beasley DG, Armstead WM, Mirro R. Postischemic cerebral microvascular responses to norepinephrine and hypotension in newborn pigs. Stroke


(Revised 1/11/16)

1989; 20:541-546. Blatteis CM, Dinarello CA, Shibata M, Llanos-Q J, Quan N, Busija DW. Does circulating interleukin-1 enter the brain? In: Mercer JB, ed. Thermal physiology. Amsterdam: Elsevier, 1989:385-390.

72. Shibata M, Leffler CW, Busija DW. Recombinant human interleukin-1a dilates pial arterioles and increases cerebrospinal fluid prostaglandin E2 in piglets. In: Mercer JB, ed. Thermal physiology. Amsterdam: Elsevier, 1989:559-561.

73. Rogers AH, Armstead WM, Mirro R, Busija DW, Leffler CW. Influence of intraarterial norepinephrine on cerebral hemodynamics of newborn pigs. Proc Soc Exp Biol 1989; 191:174-178.

74. Fletcher AM, Leffler CW, Busija DW. Effects of hypertension and sympathetic denervation on cerebral blood flow on newborn pigs. Am J Vet Res 1989; 50:754-757.

75. Leffler CW, Beasley DG, Busija DW. Cerebral ischemia alters cerebral microvascular reactivity in newborn pigs. Am J Physiol 1989; 257:H266-H271.

76. Busija DW, Leffler CW. Effects of dopamine on pial arteriolar diameter and cerebrospinal fluid prostanoid levels in piglets. J Cereb Blood Flow Metab 1989; 9:264-267.

77. Leffler CW, Busija DW, Armstead WM, Mirro R, Beasley DG. Ischemia alters cerebral vascular responses to hypercapnia and acetylcholine in piglets. Ped Res 1989; 25:180-183.

78. Busija DW, Leffler CW. Dilator effects of amino acid neurotransmitters on piglet pial arterioles. Am J Physiol 1989; 257:H1200-H1203.

79. Armstead WM, Mirro R, Busija DW, Leffler CW. Permissive role of prostanoids in acetylcholine-induced cerebral vasoconstriction. J Pharmacol Exp Therap 1989; 251:1012-1019.

80. Leffler CW, Busija DW, Mirro R, Armstead WM, Beasley DG. Effects of cerebral ischemia on brain blood flow and oxygen consumption of neonatal pigs. Am J Physiol 1989; 257:H1917-H1926.

81. Armstead WM, Mirro R, Leffler CW, Busija DW. Influence of endothelin on piglet cerebral microcirculation. Am J Physiol 1989; 257(Heart Circ. Physiol. 26):H707-H710.

82. Mirro R, Armstead WM, Busija DW, Leffler CW. Blood induced superoxide anion generation on the cerebral cortex of newborn pigs. Am J Physiol 1989; 257:H1560-H1564.

83. Wagerle LC, Busija DW. Effect of thromboxane A2/Endoperoxide antagonist SQ29548 on the contractile response to acetylcholine in the newborn piglet cerebral arteries. Circ Res 1990; 66:824-831.

84. Armstead WM, Leffler CW, Busija DW, Mirro R. Vasopressin and prostanoid mechanisms in the control of cerebral blood flow in hypotensive newborn pigs. Am J Physiol 1990; 258:H408-H413.

85. Pourcyrous M, Leffler CW, Busija DW. Role of prostanoids in cerebrovascular responses to asphyxia and reventilation in newborn pigs. Am J Physiol 1990; 259:H662-H667.


(Revised 1/11/16)

86. Busija DW, Leffler CW. Perivascular blood attenuates noradrenergic but not cholinergic effects on piglet pial arterioles. Stroke 1990; 21:441-446.

87. Leffler CW, Busija DW, Armstead WM, Shanklin DR, Mirro R, Thelin O. Activated oxygen and arachidonate effects on newborn cerebral arterioles. Am J Physiol 1990; 259:H1230-1238.

88. Busija DW, Wagerle LC, Leffler CW. Mono-l-arginine-containing compounds dilate piglet pial arterioles via an EDRF-like substance. Circ Res 1990; 67:1374-1380.

89. Leffler CW, Busija DW, Armstead WM, Mirro R. H202 effects on cerebral prostanoids and pial arteriolar diameter in piglets. Am J Physiol 1990; 258:H1382-H1387.

90. Shibata M, Leffler CW, Busija DW. Recombinant human interleukin 1α dilator and increases cerebrospinal fluid prostanoids in piglets. Am J Physiol 1990; 259:H1486-H1491.

91. Shibata M, Leffler CW, Busija DW. Cerebral hemodynamics during cortical spreading depression in rabbits. Brain Res 1990; 530:267-274.

92. Pourcyrous M, Leffler CW, Busija DW. Brain superoxide anion generation during asphyxia and reventilation in newborn pigs. Ped Res 1990; 28:618-621.

93. Leffler CW, Mirro R, Armstead WM, Busija DW. Prostanoid synthesis and vascular responses to exogenous arachidonic acid following cerebral ischemia in piglets. Prostaglandins 1990; 40:241-248.

94. Mirro R, Leffler CW, Armstead WM, Busija DW. Pressure ventilation increases brain vascular prostacyclin production in newborn pigs. Ped Res 1990; 28:609-612.

95. Armstead WM, Mirro R, Busija DW, Leffler CW. Prostanoids modulate opioid cerebrovascular responses in newborn pigs. J Pharmacol Exp Therap 1990; 255:1083-1089.

96. Mirro R, Leffler CW, Armstead WM, Busija DW. Positive-pressure ventilation alters blood-to-brain and blood-to-CSF transport in neonatal pigs. J Appl Physiol 1991; 70:584-589.

97. Armstead WM, Mirro R, Busija DW, Desiderio DM, Leffler CW. Opioids in CSF in hypotensive newborn pigs. Circ Res 1991; 68:992-929.

98. Armstead WM, Mirro R, Busija DW, Leffler CW. Opioids and prostanoid system in the control of cerebral blood flow in hypotensive pigs. J Cereb Blood Flow Metabol 1991; 11:380-387.

99. Busija DW, Leffler CW. Selective attenuation by perivascular blood of prostanoid-dependent cerebrovascular dilation in piglets. Stroke 1991; 22:484-488.

100. Shibata M, Leffler CW, Busija DW. Evidence against parenchymal metabolites directly promoting pial arteriolar dilation during cortical spreading depression in rabbits. Brain Res Bull 1991; 26:753-758.

101. Mirro R, Armstead WM, Busija DW, Leffler CW. Blood to brain transport after newborn cerebral ischemia/reperfusion injury. Proc Soc Exp Biol Med 1991; 197:268-272.


(Revised 1/11/16)

102. Shibata M, Leffler CW, Busija DW. Prostanoids attenuate pial arteriolar dilation induced by cortical spreading depression in rabbits. Am J Physiol 1991; 30:R828-R834.

103. Busija DW, Leffler CW. Effects of phorbol esters on pial arteriolar diameter and brain production of prostanoids in piglets. Circ Res 1991; 69:1253-1258.

104. Pourcyrous M, Leffler C, Bada H, Korones S, Stidham, G., Busija D. Effects of pancuronium bromide on cerebral blood flow during seizures in newborn pigs. Ped Res 1992; 31:636-639.

105. Shibata M, Leffler CW, Busija DW. Pial arteriolar constriction following cortical spreading depression is mediated by prostanoids. Brain Res 1992; 572:190-197.

106. Busija DW. Review of Human Reproductive Biology by R. E. Jones. H Biol 1992; 65:856.

107. Armstead WM, Mirro R, Zuckerman S, Busija DW, Leffler CW. The influence of opioids on local cerebral glucose utilization in the newborn pig. Brain Res 1992; 571:97-102.

108. Armstead WM, Mirro R, Thelin OP, Shibata M, Zuckerman SL, Shanklin DR, Busija DW, Leffler CW. Polyethylene glycol-superoxide dismutase and catalase attenuate the increased blood-brain barrier permeability after ischemia in piglets. Stroke 1992; 23:755-762.

109. Wagerle CW, Kurth, CD, Busija DW. Cholinergic reactivity of cerebral arteries in the developing fetal and newborn lambs. J Dev Physiol 1992; 17:51-54.

110. Busija DW, Chen J. Reversal by increased CSF [H+] and [K+] of phorbol ester-induced arteriolar constriction in piglets. Am J Physiol 1992; 263:H1455-H1459.

111. Busija DW, Chen J. Effects of trigeminal neurotransmitters on piglet arterioles. J Dev Physiol 1992; 18:67-72.

112. Busija DW, Khreis I, Chen J. Prostanoids promote pial arteriolar dilation and mask constriction to oxytocin in piglets. Am J Physiol 1992; 264:H1023-H1027.

113. Leffler CW, Thompson CC, Armstead W, Mirro R, Shibata M, Busija DW. Superoxide scavengers do not prevent ischemia-induced alteration of cerebral vasodilation in piglets. Ped Res 1992; 33:164-170.

114. Busija DW. Role of Eicosanoids in CSD-Induced Cerebrovascular Responses. In Lehmenkühler A, Grotemeyer KH, Tegtmeier F, eds. Migraine -- Basic mechanism and treatment. Munich: Urban and Schwarzenberg, 1992:395-406.

115. Busija DW, Bari F, Louis TM. Effects of hypoxic/ischemic stress on cerebral arteriolar responses to activation of NMDA receptors. In: Pearce W, Lee T, ed. Mechanisms of cerebrovascular function and regulation. Yen’s Foundation (Taiwan), 253-263, 1992.

116. Busija DW, Meng, W. Altered cerebrovascular responsiveness to N-methyl-D-aspartate after asphyxia in piglets. Am J Physiol 1993; 265:H389-H394.

117. Busija DW, Meng W. Retention of cerebrovascular dilation after cortical spreading depression in anesthetized rabbits. Stroke 1993; 24:1740-1745.


(Revised 1/11/16)

118. Pourcyrous M, Leffler CW, Bada HS, Korones SB, Busija DW. Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose. Ped Res 1993; 34:366-369.

119. Colonna DM, Meng W, Deal DD, Busija DW. Calcitonin gene-related peptide promotes cerebrovascular dilation during cortical spreading depression in rabbits. Am J Physiol 1993; 266:H1095-H1102.

120. Meng W, Busija DW. Comparative effects of angiotensin-(1-7) and angiotensin II on piglet pial arterioles. Stroke 1993; 24:2041-2045.

121. Busija DW, Thore C. Protein Kinase C and Phorbol Esters: Interactions of PKC with metabolites related to post-ischemic events. Proceedings of Microcirculatory Stasis in the Brain. Elsevier, 1993:269-275.

122. Busija DW. The role of central neural pathways in the regulation of cerebral blood flow. In: Phillis JW, ed. The regulation cerebral blood flow. New York: CRC Press, 1993:65-77.

123. Busija DW. Cerebral Autoregulation. In: Phillis JW, ed, The regulation of cerebral blood flow. New York: CRC Press, 1993:46-61.

124. Busija DW. Cerebral circulation of the fetus and newborn. In: Bevan JA, Bevan RP, eds. The Human Brain Circulation. Clifton, NJ: Humana Press, 1994:259-269.

125. Thore CR, Nam MJ, Busija DW. Phorbol ester-induced prostaglandin production in piglet cortical astroglia. Am J Physiol 1994; 267:R34-R37.

126. Pourcyrous M, Leffler CW, Bada HS, Korones SB, Busija DW. Cerebral blood flow responses to indomethacin in awake pigs. Ped Res 1994; 35:565-570.

127. Colonna DM, Deal DD, Meng W, Busija DW. Nitric oxide promotes arteriolar dilation during cortical spreading depression in rabbits. Stroke 1994; 25:2463-2470.

128. Nam MJ, Thore CR, Busija DW. Rapid induction of prostaglandin synthesis in piglet astroglial cells by interleukin 1α. Brain Res Bull 1995; 36:215-218.

129. Meng W, Tobin J, Busija DW. Glutamate-induced cerebral vasodilation is mediated by nitric oxide through NMDA receptors. Stroke 1995; 26:857-863.

130. Meng W, Colonna DM, Tobin J, Busija DW. Nitric oxide and prostaglandins interact to mediate arteriolar dilation during cortical spreading depression. Am J Physiol 1995; 269:H176-H181.

131. Nam MJ, Thore CR, Busija DW. Protein kinases and prostaglandin production in ovine astroglia. Prostaglandins 1995; 50:33-45.

132. Nam MJ, Thore CR, Busija DW. Role of protein synthesis in interleukin 1α-induced increases in prostaglandin production by ovine astroglia. Prost Leuk Ess Fatty Acids 1995; 53:69-72.

133. Meng DW, Busija DW. Oxygen radicals do not play a role in arteriolar dilation during cortical spreading depression. J. Cerebral Blood Flow Metabol. 1996; 16:175-179.

134. Busija DW, Meng W, Bari F, McGough PS, Errico RA, Tobin JR, Louis TM. Effects of ischemia on cerebrovascular responses to N-methyl-D-aspartate in piglets. Am J Physiol 1996; 270:H1225-H1230.


(Revised 1/11/16)

135. Thore CR, Nam MJ, Busija DW. Immunofluorescent localization of constitutive and inducible prostaglandin H synthase in ovine astroglia. J. Comparative Neurology 1996; 367:1-9.

136. Louis TM, Meng W, Bari F, Errico RA, Busija DW. Ischemia reduces CGRP-induced cerebral vascular dilation in piglets. Stroke 1996; 27:134-138.

137. Nam MJ, Thore CR, Busija DW. Effects of protein kinase C activation on prostaglandin production and cyclooxygenase mRNA levels in ovine astroglia. Prostaglandins 1996; 51:203-213.

138. Bari, F, Errico RA, Louis TM, Busija DW. Differential effects of short-term hypoxia and hypercapnia on N-methyl-D-aspartate-induced cerebral vasodilation in piglets. Stroke 1996, 27:1634-1640.

139. Bari F, Louis TM, Meng W, Busija DW. Global ischemia impairs ATP-sensitive K+ channel function in cerebral arterioles in piglets. Stroke 1996; 27:1874-1881.

140. Busija DW, Thore C, Beasley T, Bari F. Induction of cyclooxygenase-2 following anoxic stress in piglet cerebral arteries. Microcirculation 1996;4:379-386.

141. Bari F, Errico RA, Louis TM, Busija DW. Interaction between ATP-sensitive K+ channels and nitric oxide on pial arterioles in piglets. J Cereb Blood Flow Metab. 1996; 16:1158-1164.

142. Busija DW. Nervous control of the cerebral circulation. In: Bennett T, Gardiner SM, eds. Nervous control of the circulation. Amsterdam: Harwood Academic Publishers, 1996:177-206.

143. Busija DW. Eicosanoids and cerebrovascular control. In: Welch KMA, Caplan LR, Reis DJ, Siesjö BK, Weir B, ed. Primer on Cerebrovascular Diseases. Academic Press, 1997:93-96.

144. Busija DW, Thore C. Modulation of prostaglandin production by nitric oxide in astroglia. Prost Leuk Fatty Acids 1997; 56:355-359.

145. Colonna DM, Meng W, Deal DD, Gowda M, Busija DW. Neuronal NO promotes cerebral cortical hyperemia during cortical spreading depression in rabbits. Am J Physiol, 1997; 41:H1315-1322.

146. Bari F, Errico RA, Louis TM, Busija D. Influence of hypoxia/ischemia on cerebrovascular responses to oxytocin in piglets. J Vascular Res, 34:312-320, 1997.

147. Bari F, Louis TM, Busija DW. Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets. Stroke, 1997; 28:1272-1277.

148. Bari F, Louis TM, Busija DW. Calcium-activated K+ channels in cerebral arterioles in piglets are resistant to ischemia. J Cereb Blood Flow Metab, 1997; 17:1152-1156.

149. Bari F, Louis TM, Busija DW. Effects of ischemia on cerebral dilation to arterial hypoxia in piglets. Stroke, 1998; 29:222-228.

150. Beasley TC, Bari F, Thore C, Thrikawala N, Louis TM, Busija DW. Cerebral ischemia/reperfusion increases endothelial nitric oxide synthase levels via an indomethacin sensitive mechanism. J Cereb Blood Flow Metab, 1998; 18:88-96.


(Revised 1/11/16)

151. Bari F, Thore CR, Louis TM, Busija DW. Inhibitory effects of hypoxia and adenosine on N-methyl-D-aspartate (NMDA)- induced pial arteriolar dilatation in piglets. Brain Research, 780:237-244, 1998.

152. Beasley TC, Bari F, Thore C, Thrikawala N, Louis TM, Busija DW. Indomethacin attenuates early induction of cellular injury and iHSP 70 after cerebral ischemia/reperfusion in piglets. Dev Brain Res, 105:125-135, 1998.

153. Veltkamp R, Domoki F, Bari F, Busija DW. Potassium channel activators protect the NMDA-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets. Stroke, 29:837-843, 1998.

154. Dégì R, Bari F, Thrikawala N, Beasley TC, Thore C, Louis TM, Busija DW. Effects of anoxic stress on prostaglandin H synthase isoforms in piglet brain. Dev Brain Res, 107:265-276, 1998.

155. Thore CR, Beasley TC, Busija DW. In vitro and in vivo localization of prostaglandin H synthase in fetal sheep neurons. Neurosci Lett, 242:29-32, 1998.

156. Dégì R, Bari F, Beasley TC, Thrikawala N, Thore C, Louis TM, Busija DW. Regional distribution of prostaglandin H synthase-2 and neuronal nitric oxide synthase in piglet brain. Ped Res 43:683-689, 1998.

157. Thrikawala N, Bari F, Beasley TC, Thore C, Busija DW. Effects of ischemia on prostaglandin H synthase-2 expression in piglet choroid plexus. Prostaglandins 56:77-87, 1998.

158. Busija DW, Bari F, Dégi R, Domoki F, Veltkamp R, Louis TM, Thrikawala N, Robins G. Pathophysiology of COX-2 and NOS-derived metabolites and free radicals during brain ischemia. In: Krieglestein, J, ed. Proceedings of the 7th International Symposium on Pharmacology of Cerebral Ischemia. Medpharm Scientific Publishers, 1998:237-241.

159. Veltkamp R, Domoki F, Louis TM, Busija DW. Inhibitors of protein synthesis preserve the N-methyl-D-aspartate-induced arteriolar dilation after ischemia in piglets. Stroke 30:148-152, 1999.

160. Domoki F, Veltkamp R, Bari F, Busija DW. Cerebrovascular reactivity remains intact after cortical depolarization in newborn piglets. Pediatr Res 45; 834-837, 1999.

161. Pourcyrous M, Busija DW, Shibata M, Bada HS, Korones SB, Leffler CW. Cerebrovascular responses to therapeutic dose of indomethacin in newborn pigs. Pediatr Res 45:582-587, 1999.

162. Domoki F, Perciaccante JV, Veltkamp R, Bari F, Busija DW. Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs. Stroke 30:2713-2718, 1999.

163. Domoki F, Perciacante JV, Veltkamp R, Robins G, Bari F, Louis TM, Busija DW. Cycloheximide rapidly inhibits cortical COX activity and COX-dependent pial arteriolar dilation in piglets. American Journal of Physiology--Heart and Circulatory Physiology 46:H1113-H1118, 1999.

164. Domoki F, Velkamp R, Thrikawala N, Robins G, Bari F, Louis TM, Busija DW. Ischemia-reperfusion rapidly increases COX-2 expression in piglet cerebral arteries.


(Revised 1/11/16)

American Journal of Physiology--Heart and Circulatory Physiology 46:H1207-H1214, 1999.

165. Aschner JL, Kovacs N, Perciaccante JV, Figueroa JP Thrikawala N, Robins G, Busija DW. Endothelial nitric oxide synthase gene transfer enhances dilation of newborn piglets pulmonary arteries. American Journal of Physiology--Heart and Circulatory Physiology 46:H371-H379, 1999.

166. Shimizu K, Bari F, Busija DW. Glibenclamide enhances cortical spreading depression-associated hyperemia in the rat. NeuroReport 11:2103-2106, 2000.

167. Shimizu K, Veltkamp R, Busija DW. Characteristics of induced spreading depression after transient focal ischemia in the rat. Brain Research 861:316-324, 2000.

168. Veltkamp R, Warner DS, Domoki F, Brinkhous AD, Toole JF, Busija DW. Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Research 853:68-73, 2000.

169. Zhao Z, Chen SR, Eisenach JC, Busija DW, Pan HL. Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. Neuroscience 97:743-748, 2000.

170. Tomita M, Suzuki N, Hamel E, Busija D, Lauritzen M. Regulation of cerebral microcirculation--update. Keio J Med 49:26-34, 2000.

171. Domoki F, Thrikawala N, Robins GS, Bari F, Busija DW. Kainic acid rapidly induces cyclooxygenase-2 in piglet cerebral cortex. NeuroReports, 11:3435-3438, 2000.

172. Dégì R, Thore C, Bari F, Thrikawala N, Nógrádi A, Robins G, Domoki F, Beasley TC, Busija D. Ischemia increases prostaglandin H synthase-2 levels in retina and visual cortex in piglets. Graefe’s Arch Clin Exp Ophthal, 239:59-65, 2001.

173. Rajapakse N, Shimizu K, Payne M, Busija D. Isolation and characterization of intact mitochondria from neonatal rat brain. Brain Res Protocols, 8:176-183, 2001.

174. Lacza Z, Puskar M, Figueroa JP, Zhang J, Rajapakse N, Busija DW. Mitochondrial nitric oxide synthase is constitutively active and functionally upregulated in hypoxia. Free Radical Biol Med, 31:1609-1615, 2001.

175. Busija DW, Domoki F, Thrikawala N, Bari F. Effects of ischemia on expression of cyclooxygenase and endothelial nitric oxide synthase in the cerebral circulation. In: Fukuuchi Y, Tomita M, Koto A, ed. Ischemic blood flow in the brain. Springer-Verlag, 91-97, 2001.

176. Busija DW. Prostaglandins and other Eicosanoids. In: Edvinsson L, Krause D, ed. Cerebral blood flow and metabolism. Lippincott Williams and Wilkins, 325-338, 2002.

177. Busija DW, Domoki F, Bari F, Louis TM. Effects of activation of glutamate receptors on neurons and blood vessels. In: Tomita, M, ed. Brain activation and CBF control. Elsevier, 305-312, 2002.

178. Domoki F, Perciaccante JV, Shimizu K, Puskar M, Busija DW, Bari F. N-methyl-D-aspartate-induced vasodilation is mediated by endothelium-independent nitric oxide release in piglets. Am J Physiol, 282:H1404-H1409, 2002.


(Revised 1/11/16)

179. Domoki F, Perciaccante JV, Puskar M, Bari F, Busija DW. Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia/ischemia in piglets. NeuroReports, 12:4065-4068, 2001.

180. Miller AW, Dimitropoulou C, Han G, White RE, Busija DW, Carrier GO. Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. Am J Physiol 281:H1524-H1531, 2001.

181. Shimizu K, Miller AW, Erdos B, Bari F, Busija DW. Role of endothelium in hyperemia during cortical spreading depression in the rat. Brain Res, 22:40-49, 2002.

182. Veltkamp R, Rajapakse N, Robins G, Puskar M, Shimizu K, Busija DW. Transient, focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels. Stroke, 33:2704-2710, 2002.

183. Erdos B, Miller AW, Busija DW. Impaired endothelium-mediated relaxation in isolated cerebral arteries from insulin-resistant rats. Am J Physiol Heart Circ Physiol, 282:H2060-H2065, 2002.

184. Shimizu K, Lacza Z, Rajapakse N, Horiguchi T, Snipes J, Busija DW. MitoKATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat. Am J Physiol, 283:H1005-H1011, 2002.

185. Rajapakse N, Shimizu K, Snipes J, Lacza Z, Busija D. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci Lett, 327:208-212, 2002.

186. Lacza Z, Puskar M, Kis B, Perciaccante JV, Miller AW, Busija DW. Hydrogen peroxide acts as an EDHF in the piglet pial vasculature in response to bradykinin. Am J Physiol, 283:H406-H411, 2002.

187. Erdos B, Miller AW, Busija DW. Alterations in calcium-activated and ATP-dependent potassium channel function in cerebral arteries of insulin resistant rats. Am J Physiol, 282:H2060-H2065, 2002.

188. Perciaccante JV, Domoki F, Puskar M, Busija DW. Effects of hypothermia on neuronal-vascular function after cerebral ischemia in piglets. Am J Physiol Regul Integr Comp Physiol, 283:R1362-1367, 2002.

189. Miller AW, Tulbert C, Puskar M, Busija DW. Enhanced endothelin activity prevents vasodilation to insulin in insulin resistance. Hypertension, 40:78-82, 2002.

190. Busija DW. Prostaglandins and other Eicosanoids. In: Edvinsson L, Krause D, ed. Cerebral blood flow and metabolism. Lippincott Williams and Wilkins, 325-338, 2002.

191. Busija DW, Domoki F, Bari F, Louis TM. Effects of activation of glutamate receptors on neurons and blood vessels. In: Tomita, M, ed. Brain activation and CBF control. Elsevier, 305-312, 2002.

192. Miller AW, Katakam PVG, Lee HC, Tulbert CD, Busija DW, Weintraub NL. Arachidonic acid induced vasodilation of rat small mesenteric arteries is lipoxygenase dependent. J Pharmacol Exp Ther, 304:139-144, 2003.

193. Horiguchi T, Kis B, Rajapakse N, Shimizu K, Busija DW. Opening of mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats. Stroke 34:1015-1020, 2003.


(Revised 1/11/16)

194. Shimizu D, Rajapakse N, Horiguchi T, Payne RM, Busija DW. Protective effect of a new nonpeptidyl mimetic of superoxide dismutase, M40401, against transient focal cerebral ischemia in the rat. Brain Res 963:8-14, 2003.

195. Kis B, Abraham CS, Deli MA, Kobayashi H, Niwa M, Yamashita H, Busija DW, Ueta Y. Adrenomedullin, an autocrine mediator of blood-brain barrier function. Hypertension Res 26:S61-70, 2003

196. Rajapakse N, Kis B, Horiguchi T, Snipes J, Busija D. Diazoxide pretreatment induces delayed preconditioning in astrocytes against oxygen glucose deprivation and hydrogen peroxide-induced toxicity. J Neurosci Res 73:206-214, 2003.

197. Lacza Z, Horvath E, Busija DW. Neural stem cell transplantation in cold lesion: a novel approach for the investigation of brain trauma and repair. Brain Res Protoc 11:145-154, 2003.

198. Shimizu K, Rajapakse N, Horiguchi T, Payne RM, Busija DW. Neuroprotection against hypoxia-ischemia in neonatal brain by novel superoxide dismutase mimetics. Neurosci Lett 346:41-44, 2003.

199. Lacza Z, Horvath EM, Komjati K, Hortobagyi T, Szabo C, Busija DW. PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma. Int J Mol Med 12:153-159, 2003.

200. Lacza Z, Snipes JA, Zhang J, Horvath EM, Figureroa JP, Szabo C, Busija D. W. Mitochondrial nitric oxide synthase is not eNOS, nNOS, or iNOS. Free Rad Biol Med 35: 1217-1228, 2003.

201. Lacza Z, Snipes JA, Miller AW, Czabo C, Grover G, Busija DW. Heart mitochondria contain functional ATP dependent K+ channels. J Mol Cell Card 35: 1339-1347, 2003.

202. Kis B, Snipes JA, Isse T, Nagy K, Busija DW. Putative cyclooxygenase-3 expression in rat brain cells. J Cerebral Blood Flow Metab 23: 1287-1292, 2003.

203. Kis B, Rajapakse N, Snipes JA, Nagy K, Horiguchi T, Busija DW. Diazoxide induces delayed preconditioning in cultured rat cortical neurons. J Neurochem 87:969-980, 2003.

204. Jordan JE, Simandle SA, Tulbert CD, Busija DW, and Miller AW. Fructose-fed rats are protected against ischemia/reperfusion injury. J Pharmacol Exp Therap 307: 1007-1011, 2003.

205. Lacza Z, Snipes JA, Kis B, Szabo C, Grover G, Busija DW. Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain. Brain Res 19: 27-36, 2003.

206. Kis B, Snipes JA, Deli MA, Abraham CS, Yamashita H, Ueta Y, Busija DW. Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins. Acta Neurochir 86:565-568 [Suppl], 2003.

207. Erdős B, Snipes JA, Miller AW, Busija DW. Cerebrovascular dysfunction in Zucker obese rats is mediated by oxidative stress and protein kinase C. Diabetes 53: 1352-1359, 2004.

208. Erdős B, Snipes JA, Miller AW, Busija DW. Subtype specific potassium channel dysfunction in cerebral arteries of insulin-resistant rats is mediated by reactive oxygen


(Revised 1/11/16)

species. Stroke 35: 964-969, 2004. 209. Kis B, Nagy K, Snipes JA, Rajapakse N, Horiguchi T, Grover GJ, Busija DW. The

mitochondrial KATP channel opener BMS191095 induces neuronal preconditioning. Neuroreport 15:345-349, 2004.

210. Miller AW, Tulbert C, Busija DW. Rosuvastatin treatment reverses impaired coronary artery vasodilation in fructose-fed insulin resistant rats. Am J Physiol 287: R157-R160, 2004.

211. Kis B, Snipes JA, Bari F, Busija DW. Regional distribution of cyclooxygenase-3 mRNA in the rat central nervous system. Mol Brain Res 126: 78-80, 2004.

212. Busija DW, Lacza Z, Rajapakse N, Shimizu K, Kis B, Bari F, Domoki F, Horiguchi T. Targeting mitochondrial ATP-sensitive potassium channels—A novel approach to neuroprotection. Brain Res Rev 46: 282-294, 2004.

213. Nagy K, Kis B, Rajapakse NC, Bari F, Busija DW. Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation. J Neurosci Res 76:697-704, 2004.

214. Lacza Z, Snipes JA, Zhang J, Horvath EM, Figureroa JP, Szabo C, Busija DW. Lack of mitochondrial nitric oxide production in the brain. J Neurochem 90: 942-951, 2004.

215. Domoki F, Bari F, Nagy K, Busija DW, Siklos L. Diazoxide prevents mitochondrial swelling and Ca (2+) accumulation in CAI pyramidal cells after cerebral ischemia in newborn pigs. Brain Research 1019: 97-104, 2004.

216. Busija DW, Miller AW, Katakam P, Simandle S, Erdős B. Mechanisms of vascular dysfunction in insulin resistance. Cur Opin Invest Drugs 5:929-935, 2004.

217. Erdős B, Snipes JA, Kis B, Miller AW, Busija DW. Vasoconstrictor mechanisms in the cerebral circulation are unaffected by insulin resistance. Am J Physiol 287:R1456-61, 2004.

218. Kis B, Snipes JA, Simandle SA, Busija DW. Acetaminophen-sensitive prostaglandin production in rat cerebral endothelial cells. Am J Physiol 288:R897-902, 2005.

219. Katakam P, Tulbert CD, Snipes JA, Erdos B, Miller AW, Busija DW. Impaired insulin-induced vasodilation in small coronary arteries of Zucker Obese rats is mediated by reactive oxygen species. Am J Physiol 288:H854-860, 2005.

220. Horiguchi T, Snipes JA, Kis B, Shimizu S, Busija DW. The role of nitric oxide in the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Brain Res 1039:84-89, 2005.

221. Snipes JA, Kis B, Shelness GS, Hewett JA, Busija DW. Cloning and Characterization of Cyclooxygenase-1b (putative COX-3) in Rat. J Pharmacol Exp Ther 313:668-676, 2005.

222. Chen L, Kis B, Busija DW, Yamashita H, Ueta Y. Adenomedullin protects rat cerebral endothelial cells from oxidant damage in vitro. Regul Pept 130:27-34, 2005.

223. Domoki F, Kis B, Nagy K, Farkas E, Busija DW, Bari F. Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. Am J Physiol 289:H368-373, 2005.


(Revised 1/11/16)

224. Busija DW, Katakam P, Rajapakse NC, Kis B, Grover G, Domoki F, Bari F. Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria. Brain Res Bull 66:85-90, 2005.

225. Simandle S, Kerr BA, Lacza Z, Eckman D, Busija DW, Bari F. Piglet pial arteries respond to NMDA in vivo but not in vitro. Microvas Res 70:76-83, 2005.

226. Simandle S, Erdos B, Snipes JA, Miller AW, Busija DW. Insulin resistance does not impair contractile responses of cerebral arteries. Life Sci 16:2262-2272, 2005.

227. Kis B, Snipes JA, Busija DW. Acetaminophen and the COX-3 puzzle: Sorting out Facts, Fictions, and Uncertainties. J Pharmacol Exp Ther 315:1-7, 2005.

228. Lenzser G, Kis B, Bari F, Busija DW. Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. Brain Res 105:72-80, 2005.

229. Lacza Z, Horvath EM, Pankotai E, Csordas, Kollai M, Szabo C, Busija DW. The novel red-fluorescent probe DAR-4M measures reactive nitrogen species rather than NO. J Pharmacol Toxicol Meth 52:335-340, 2005.

230. Lacza Z, Pankotai E, Csordas A, Gero D, Kiss L, Horvath EM, Kollai M, Busija DW, Szabo C. Mitochondrial NO and reactive nitrogen species production: Does mtNOS exist? Nitric Oxide 14:162-168, 2006.

231. Busija DW, Miller AW, Katakam P, Erdos B. Insulin resistance and associated dysfunction of resistance vessels and arterial hypertension. Minerva Medica 96:223-232, 2005.

232. Horiguchi T, Kis B, Rajapakse N, Shimizu K, Busija DW. Cortical spreading depression-induced tolerance to transient focal cerebral ischemia in halothane anesthetized rats is affected by anesthetic level but not ATP-sensitive potassium channels. Brain Res 1062(1-2):127-33, 2005.

233. Erdős B, Snipes JA, Tulbert C, Katakam P, Miller AW, Busija DW. Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H-oxidase-dependent superoxide anion production. Am J Physiol 290:H1264-1270, 2006.

234. Katakam PVG, Tulbert C D, Busija DW. Impaired Endothelin-Induced Vasoconstriction in Coronary Arteries of Zucker Obese Rats is Associated with Uncoupling of Ca2+ Signaling. Am J Physiol Regul Integr Comp Physiol, special issue on Metabolic Syndrome, 290:R145-153, 2006.

235. Busija DW, Miller AW, Katakam P, Erdos B. Adverse effects of reactive oxygen species on vascular reactivity in insulin resistance. Antioxidants & Redox Signaling 8:131-1140, 2006.

236. Kis B, Isse T, Snipes JA, Chen L, Yamashita H, Ueta Y, Busija DW. Effects of LPS stimulation on the expression of prostaglandin carriers in the cells of the blood-brain and blood-cerebrospinal fluid barriers. J Appl Physiol, special issue on Fever, 100:1392-1399, 2005.

237. Kis B, Chen L, Ueta Y, Busija DW. Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood-brain barrier. Peptides


(Revised 1/11/16)

27:211-222, 2006. 238. Bari F, Nagy K, Guidett P, Schwarcz R, Busija DW, Domoki F. Kynurenic acid

attenuates NMDA-induced pial arteriolar dilation in newborn pigs. Brain Res 1069:39-46, 2006.

239. Lacza Z, Busija DW. Urotensin-II is a nitric oxide-dependent vasodilator in the pial arteries of the newborn pig. Life Sciences 78:2763-2766, 2006.

240. Horvath EM, Lacza Z, Csordas A, Szabo C, Kollai M, Busija DW. Graft derived cells with double nuclei in the penumbral region of experimental brain trauma. Neurosci Lett 396:182-186, 2005.

241. Lacza Z, Kozlov AV, Pankotai E, Csordas A, Wolf G, Redl H, Kollai M, Szbo C, Busija DW, Horn TFW. Mitochondria produce reactive nitrogen species via an arginine-independent pathway. Free Rad Res 40:369-378, 2006.

242. Gaspar T, Kis B, Snipes J, Lenzser G, Mayanagi K, Bari F, Busija D. Transient glucose and amino acid deprivation induces delayed preconditioning in cultured rat cortical neurons. J Neurochem 98:555-565, 2006.

243. Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. Cyclooxygenase-2 mediates the development of cortical spreading depression (CSD) – induced tolerance to transient focal cerebral ischemia in rats. Neuroscience 140:723-730, 2006.

244. Kis B, Snipes JA, Gaspar T, Lenszer G, Tulbert CD, Busija DW. Cloning of cyclooxygenase-1b (putative COX-3) in mouse. J Inflam Res 55:274-278, 2006.

245. Farkas E, Domoki F, Institoris A, Annahazi A, Busija DW, Bari F. Neuroprotection by diazoxide in animal models for cerebrovascular disorders. Vasc Dis Prev 3: 253-263, 2006.

246. Chen L, Kis B, Hashimoto H, Busija DW, Takei Y, Yamashita H, Ueta Y. Adrenomedullin 2 protects rat cerebral endothelia cells from oxidative damage in vitro. Brain Res 1086:42-49, 2006.

247. Katakam PV, Jordan JE, Snipes JA, Tulbert CD, Miller AW, Busija DW. Myocardial preconditioning against ischemia-reperfusion is abolished in Zucker obese rats with insulin resistance. Am J Physiol 292:R920-6, 2007.

248. Csordas A, Pankotai E, Snipes JA, Cselenyak A, Sarszegi Z, Czirak A, Gaszner B, Papp L, Benko R, Kiss L, Kovacs E, Kollai M, Szabo C, Busija DW, Lacza Z. Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide. Life Sci 80:633-637, 2007.

249. Lenzser G, Kis B, Snipes JA, Gaspar T, Sandor P, Komjati K, Szabo C, Busija DW. Contribution of poly (ADP-ribose) polymerase to post-ischemic blood-brain barrier damage in J Cereb Blood Flow Metabol 27:1318-26, 2007.

250. Gaspar T, Kis B, Snipes JA, Lenzser G, Mayanagi K, Bari F, Busija DW. Neuronal preconditioning with the antianginal drug, Bepridil. J Neurochem 102:595-608, 2007.

251. Hortobágyi, L., Kis, B., Hrabák, A., Horváth, B., Huszty, G., Benyó Sr., Z., Sándor, P., Busija, DW, Benyó Jr., Z. Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of the cyclooxygenase pathway. Brain Res 1131:129-137, 2007.


(Revised 1/11/16)

252. Kis B, Ueta Y, Busija DW. Peptide mediators of the brain endothelium. In: Handbook of Neurochemistry. Springer, Berlin, 191-208, 2007.

253. Busija DW, Bari F, Domoki F, Mayanagi K, Gaspar T, Lenzser G, Kis B. Preconditioning the neurovascular unit against anoxic/hypoxic stress in the neonate: Targeting the mitochondrial ATP-sensitive potassium channel. In: Mechanisms of hypoxic brain injury in the newborn and potential strategies for neuroprotection. Transworld Research Network, Kerala, 201-218, 2007.

254. Mayanagi K, Gaspar T, Katakam PV, Kis B, Busija DW. The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 27(2):348-55, 2007.

255. Busija DW, Bari F, Domoki F, Louis T. Mechanisms involved in the cerebrovascular dilator effects of N-methyl-D-aspartate in cerebral cortex. Brain Res Rev 56:89-100, 2007.

256. Lenti L, Domoki F, Kis D, Hegyi O, Toth GK, Busija DW, Bari F. Pituitary adenylate cyclase-activating polypeptide induces pial arteriolar vasodilation through cyclooxygenase-dependent and independent mechanisms in newborn pigs. Brain Res, 1165:81-88, 2007.

257. Mayanagi K, Gaspar T, Katakam PV, Busija DW. Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats. Brain Res, 1168:106-111, 2007.

258. Gaspar T, Katakam Pk Snipes JA, Kis B, Domoki F, Bari F, Busija DW. Delayed neuronal preconditioning by NS1619 is independent of calcium activated potassium channels. J Neurochem, 105:1115-1128, 2008.

259. Lu B, Poirier C, Gaspar T, Gratzke C, Harrison W, Busija D, Matsuk M, Andersson KE, Overbeek PA, Bishop CE. A mutation in the inner mitochondrial membrane peptidase 2-like gene (IMMP21) affects mitochondrial function and impairs fertility in mice. Biol Reprod, 78:601-610, 2008.

260. Gaspar T, Snipes JA, Busija AR, Kis B, Domoki F, Bari F, Busija DW. ROS-independent preconditioning in neurons via activation of mitoKATP channels by BMS-191095. J Cereb Blood Flow Metab, 28:1090-1103, 2008.

261. Domoki F, Zimmermann A, Tóth-Szki V, Busija DW, Bari F. Acetazolamide induces indomethacin and ischaemia-sensitive pial arteriolar vasodilation in the piglet. Acta Paediatr, 97:280-284, 2008.

262. Institoris A, Domoki F, Busija DW, Bari F. the role of cyclooxygenase(COX)-2 in ischemic brain injury. In: Recent Advances and New Strategies in Stroke Research. Ed: Erdo F. pp.135-150, 2008.

263. Mayanagi K, Katakam PV, Gaspar T, Domoki F, Busija DW. Acute treatment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemia. J Cerebral Blood Flow Metabol, 28:1927-1935, 2008.

264. Busija DW, Bari F, Domoki, Horiguchi T, Shimizu K. Mechanisms Involved in the Cerebrovascular Dilator Effects of Cortical Spreading Depression. Prog Neurobiol, 86:417-433, 2008.

265. Busija DW, Gaspar T, Domoki F, Bari F. Mitochondrial-Mediated Suppression of


(Revised 1/11/16)

ROS Production Upon Exposure of Neurons to Lethal Stress: Mitochondrial Targeted Preconditioning. Advanced Drug Delivery Reviews 16:1471-1477, 2008.

266. Domoki F, Kis B, Gaspar T, Bari F, Busija DW. Cerebromicrovascular endothelial cells are resistant to L-glutamate. Am J Physiol Regul Integr Comp Physiol 296:R289-298, 2008.

267. Domoki F, Kis B, Gaspar T, Snipes JA, Parks J, Bari F, Busija DW. Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. Am J Physiol Cell Physiol, 296:C97-C105, 2009.

268. Katakam PV, Domoki F, Snipes JA, Busija AR, Jarajapu YP, Busija DW. Impaired mitochondria dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance. Am J Physiol Regul Integr Comp Physiol, 296:R289-98, 2009.

269. Lacza Z, Pankotai E, Busija DW. Mitochondrial Nitric Oxide Synthase: Current Concepts and Controversies. Frontiers Biosci, E1: 218-225, 2009.

270. Gaspar T, Domoki F, Lenti L, Katakam PVG, Snipes JA, Bari F, Busija DW. Immediate neuronal preconditioning with NS1619. Brain Res, 1285:196-207, 2009.

271. Katakam PVG, Domoki F, Lenti L, Gaspar T, Snipes JA, Busija DW. Cerebrovascular responses to insulin in rats. J Cereb Blood Flow Metabol, 29:1955-67, 2009.

272. Gaspar T, Domoki F, Lenti L, Institoris A, Snipes JA, Bari F, Busija DW. Neuroprotective effect of adenoviral catalse gene transfer in cortical neuronal cultures. Brain Res, 1270: 1-9, 2009.

273. Lenti L, Zimmermann A, Kis D, Oláh, Tóth, Hegyi O, Busija DW, Bari F, Domoki F. PACAP and VIP differentially preserve neurovascular reactivity after global cerebral ischemia in newborn pigs. Brain Res, 1283:50-57, 2009.

274. Lenti L, Domoki F, Gaspar T, Snipes A, Bari F, Busija DW. N-Methyl-D-Aspartate induces cortical hyperemia through cortical spreading depression-dependent and -independent mechanisms in rats. Microcirculation, 4:1-11, 2009.

275. Domoki F, Kis B, Gáspár T, Snipes JA, Bari F, Busija DW. Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. Neurochem Int, 56:404-409, 2010.

276. Institoris A, Snipes JA, Katakam PV, Domoki F, Boda K, Bari F, Busija DW. Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol, 300:H2080-2087, 2011

277. Katakam PV, Snipes JA, Steed MM, Busija DW. Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats. J Cereb Blood Flow Metab, 32(5):792-804, 2012.

278. Busija DW, Bari F, Domoki F, Katakam PV. Mitochondrial influences on the neurovascular unit. Japanese Journal of Cerebral Blood Flow and Metabolism. 23:17-29, 2012.

279. Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in Oxidative Stress Status and Expression of MKP-1 in Dorsal Medulla


(Revised 1/11/16)

of Transgenic Rats with Altered Brain Renin-Angiotensin System. Am J Physiol Regul Integr Comp Physiol. 303:R799-806, 2012.

280. Institoris A, Lenti L, Domoki F, Wappler E, Gáspár T, Katakam PV, Bari F, Busija DW. Cerebral microcirculatory responses of insulin resistant rats are preserved to physiological and pharmacological stimuli. Microcirculation. 19:749-56, 2012.

281. Clark D, Tuor UI, Thompson R, Institoris A, Kulynych A, Zhang X, Kinniburgh DW, Bari F, Busija DW, Barber PA. Protection against Recurrent Stroke with Resveratrol: Endothelial Protection. PLoS One. 7(10):e47792, 2012.

282. Katakam PVG, Wappler E, Katz P, Rutkai I, Institoris A, Domoki F, Gáspár T, Grovenburg SM, Snipes JA, Busija DW. Depolarization of Mitochondria in Endothelial Cells Promotes Cerebral Vascular Vasodilation by Activation of Nitric Oxide Synthase. Art Throm Vasc Biol 33:752-9, 2013.

283. Wappler EA, Institoris A, Dutta S, Katakam PV, Busija DW. Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. PLos One. 8(5):e63206, 2013.

284. Carvalho C, Katz PS, Dutta S, Katakam PVG, Moreira PI, Busija DW. Increased susceptibility to β-amyloid toxicity in rat brain microvascular endothelial cells under hyperglycemic conditons. J Alzheimers Dis. 38:75-83, 2014.

285. DW Busija, Katakam, PV. Mitochondrial mechanisms in cerebral vascular control: Shared signaling pathways with preconditioning. J Vasc Res. 2014, 51:175-189.

286. Katakam PVG, Gordon A, Sure VNLR, Rutkai I, Busija DW. Diversity of mitochondrial-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin resistant rats. Am J Physiol. 2014, 307:H493-503

287. Rutkai I, Katakam PVG, Dutta S, Busija DW. Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: A potential target for therapies. Am J Physiol. 2014, 307:H958-966.

288. Dutta S, Rutkai I, Katakam PVG, Busija DW. The mechanistic target of rapamycin (mTOR) pathway and S6 Kinase mediate diazoxide preconditioning in primary rat cortical neurons. J Neurochem. 2015, 134(5):845-56.

289. Rutkai, I, Dutta S, Katakam, PVG, Busija DW. Dynamics of enhanced mitochondrial respiration in female compared with male cerebral arteries. Am J Physiol. 2015, 309:H1490-500.

290. Busija DW, Rutkai I, Katakam PV. Mitochondrial depolarization and other vascular cells and their role in the regulation of cerebral vascular tone. In: Ion Channels in Vascular Disease. 2015. Ed: Levitan, I, Dopico, M. Springer Publishers, in press.

291. Busija DW, Rutkai I, Dutta S, Katakam PV. Role of mitochondria in cerebral vascular function: Energy production, cellular protection, and regulation of vascular tone. Comprehensive Physiology, in press, 2016.

INVITED PRESENTATIONS:


(Revised 1/11/16)

January, 1981. Department of Anesthesiology, John Hopkins University, Baltimore. Sympathetic nerves and cerebral circulation.

June, 1981. Iowa City, Iowa. Invited speaker at symposium on Effects of nerves and neurotransmitters on cerebral blood flow.

June, 1981. St. Louis, Missouri. Invited speaker at 10th International Symposium on Cerebral Blood Flow and Metabolism.

March, 1982. Department of Neurosurgery, University of Iowa, Iowa City. Regulation of cerebral blood flow.

April, 1982. Department of Physiology and Biophysics, University of Tennessee, Memphis. Sympathetic effects on cerebral blood flow.

June, 1983. Paris, France. Invited speaker at 11th International Symposium on Cerebral Blood Flow and Metabolism.

January, 1985. Department of Pediatrics (Neonatology Section), University of Pennsylvania, Philadelphia. Prostaglandins and the neonatal cerebral circulation.

September, 1985. Departments of Pharmacology and Neurosurgery, Louisiana State University, New Orleans. Role of prostaglandins and sympathetic nerves in regulation of the cerebral circulation. January, 1986. Keystone, Colorado. Invited speaker at workshop on Unified Mechanisms for Brain Blood Flow and Cardiorespiratory Control, at 19th Winter Conference on Brain Research.

October, 1986. Department of Neurological Surgery, University of New York at Stoney Brook. Prostaglandins, sympathetic nerves and cerebral blood flow.

April, 1987. Department of Physiology, University of Pennsylvania, Philadelphia. Prostaglandins and cerebral blood flow.

April, 1987. Neonatology section (Pediatrics), University of Pennsylvania, Philadelphia. Regulation of neonatal cerebral blood flow.

June, 1987. Montreal, Canada. Invited speaker at 13th International Symposium on Cerebral Blood Flow and Metabolism.

September, 1987. Department of Medicine, Medical College of Ohio, Toledo. Prostanoid modulation of neural effects on cerebral blood vessels.

October, 1987. Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, New Jersey. Regulation of the cerebral circulation by prostanoids in the neonatal period. November, 1987. Cerebrovascular Research Center, University of Pennsylvania, Philadelphia. Prostanoids and the cerebral circulation. May, 1988. Las Vegas, Nevada. Invited speaker at FASEB Symposium on Regulation of Cerebral Blood Flow. April, 1989. Department of Anesthesia, Pennsylvania State University, Hershey, PA. Prostaglandins and the cerebral circulation. April, 1989. Department of Anatomy & Neurobiology, University of Tennessee, Memphis. Regulation of the cerebral circulation.


(Revised 1/11/16)

March, 1990. Department of Physiology/Pharmacology, Bowman Gray School of Medicine, Winston-Salem, NC. Regulation of the cerebral circulation by neurotransmitters and prostanoids. May, 1991. International Conference on Prostaglandins, Leukotrienes and Lipoxins, Washington, DC. Activation of protein kinase C constricts pial arterioles and increases brain production of prostanoids in piglets.

June, 1991. International Symposium on Cerebral Blood Flow and Metabolism, Miami, FL. Prostanoids attenuate pial arteriolar dilation during cortical spreading depression in rabbits.

August, 1991. Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond, VA. Vascular responses to cortical spreading depression.

February, 1992. 13th Annual Winter Neuropeptide Conference, Breckenridge, CO. Neurohypophyseal peptides in the control of the cerebral microvasculature.

March, 1992. International symposium on Migraine-Basic mechanisms and treatment, Münster, Germany. Eicosanoids and spreading depression.

August , 1992. Department of Physiology & Biophysics, University of Tennessee, Memphis, TN. Cerebral hemodynamics during cortical spreading depression.

October, 1992. Invited speaker at Symposium on The Human Brain Circulation: Functional Changes in Disease, Vergennes, VT. Cerebral circulation of the fetus and newborn.

November, 1992. Invited speaker at Symposium on Neurobiology Update for Neurosurgeons, Woods Hole, MA. "Regulation of the cerebral circulation."

January, 1993. Dept. of Anesthesiology, Childrens Hospital of Philadelphia, Philadelphia, PA. "Cerebral hemodynamics during cortical spreading depression."

May, 1993. Departments of Pediatrics & Physiology. East Carolina University School of Medicine, Greenville, NC. "Effects of asphyxia on the neonatal cerebral circulation."

May, 1993. Invited speaker at Symposium on Microcirculatory Stasis in the Brain, Tokyo, Japan. "Protein kinase C and phorbol esters: interactions of PKC in post-ischemic events."

July, 1993. Dept. of Neurosurgery, Univ. of Texas, Houston, TX. "Blood flow regulation during cortical spreading depression."

January, 1994. Department of Internal Medicine, University of Texas, Houston, TX. "Effects of Cytokines on Prostaglandin H Synthase in Astroglia."

October, 1994. Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI. "Effects of oxygen radicals on regulation of the cerebral circulation."

January, 1995. Invited speaker at 28th Winter Conference on Brain Research, Steamboat Springs, CO. Cerebrovascular responses to anoxic stress.

June, 1997. Cambridge Neuroscience, Inc., Boston, MA. Regulation of cerebral hemodynamics during cortical spreading depression.

June, 1997. Invited speaker at Symposium on mechanisms of cerebrovascular function and regulation, Williamsburg, VA. Effects of ischemic stress on cerebral arteriolar responses to activation of glutamate receptor channels and potassium channels. September, 1997. Department of Internal Medicine, University of Iowa, Iowa City, IA. Effects of anoxic stress on cerebral blood vessels and tissues.


(Revised 1/11/16)

July, 1998. Department of Physiology, Albert Szent-Györgyi Medical University, Szeged, Hungary. Effects of ischemia on gene expression in brain.

July, 1998. Invited speaker at 7th International Symposium on Pharmacology of Cerebral Ischemia, Marburg, Germany. Pathophysiology of COX-2- and NOS-derived metabolites and free radicals during brain ischemia. September, 1998. Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC. Effects of COX-2- and NOS-derived metabolites and oxygen radicals on cerebral tissues and blood vessels after ischemia.

October, 1998. Graduate Program in Molecular and Cellular Pathophysiology, Wake Forest University School of Medicine, Winston-Salem, NC. Regulation of COX-2 expression in brain blood vessels. October, 1998. Graduate Program in Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC. Effects of ischemia on gene expression in brain. December, 1998. Department of Physiology and Perinatal Biology Program, Loma Linda Medical School, Loma Linda, CA. Altered gene expression in neonatal brain after hypoxic/ischemic stress and Physiological regulation of the newborn cerebral circulation.

April, 1999. Invited speaker at Symposium on Molecular approaches to the study of the cerebral circulation at Experimental Biology--1999, Washington, D.C. Cerebral vascular gene expression after brain injury. June, 1999. Invited speaker at Symposium on Chemical and neuronal control of the cerebral circulation at Brain 99, Copenhagen Denmark. Cerebrovascular receptors and ion channels. November, 1999. Invited speaker at Symposium on Ischemic blood flow in the brain, Tokyo, Japan. Effects of ischemia on expression of cyclooxygenase and endothelial nitric oxide synthase in the cerebral circulation.

November, 1999. Invited speaker at Keio University symposium on neurosurgery updates, Mishima, Japan. Role of potassium channels in protecting the brain against ischemia.

September, 2000. Department of Anesthesiology, Baylor College of Medicine, Houston, TX. Effects of Ischemia/Reperfusion on the cerebral circulation.

September, 2000. Department of Physiology, Texas A and M University, School of Health Sciences, College Station, TX. Acute and chronic effects of ischemia on cerebral blood vessels. January, 2001. Department of Perinatal Biology, Loma Linda School of Medicine, Loma Linda, CA. Effects of ischemia on NMDA-induced dilation in the piglet. February, 2001. Department of Neurosurgery, University of Mississippi School of Medicine, Jackson, MS. Effects of ischemia on cerebral arteries and tissues. June, 2001. Invited speaker at Symposium on Brain activation and cerebral blood flow control, Tokyo, Japan. Effects of activation of glutamate receptors on neurons and blood vessels.

August, 2001. Invited speaker at Symposium on Cerebral microvascular control in health and during diseases that predispose to stroke, 7th World Congress for Microcirculation, Sydney, Australia. Brain blood flow in the newborn.


(Revised 1/11/16)

September, 2001. Department of Physiology, University of Szeged, Szeged, Hungary. Studies on the cerebral circulation. September, 2001. Institute of Human Physiology and Clinical Experimental Research, Semmelweis University School of Medicine, Budapest, Hungary. Effects of ischemia on cerebral tissues and arteries. July, 2002. Invited speaker at 4th International Congress of Pathophysiology, Budapest, Hungary. Mitochondrial ATP-sensitive potassium channel opener diazoxide reduces neuronal damage after ischemia in rat. March, 2003. Invited speaker at Winter Eicosanoid meeting, Baltimore, MD. Cyclooxygenase-3 expression in brain cells. September, 2003. Department of Physiology, Louisiana State University, Activation of KATP channels protect the brain against injury. September, 2003. Department of Pharmacology, Louisiana State University, Insulin resistance and vascular dysfunction. Sepember, 2003. Invited speaker, Council on Hight Blood Pressure Workshop, Washington, D.C., Vascular dysfunction in insulin resistance. April, 2004. Featured Topic Speaker, Experimental Biology’04 Meeting, Mechanisms of potassium channel dysfunction in cerebral arteries in insulin resistance.

April, 2004. Featured Topic Speaker, Experimental Biology 2004 Meeting, Expression of cyclooxygenase-3 in endothelium—physiologically important or mistake of nature?

July, 2004. Invited speaker, British Pharmacological Society Meeting, Cyclooxygenase-3 MRNA in rat cerebral endothelium encodes a new protein named cyclooxygenase variant protein. September, 2004. Vascular Biology Center, Medical College of Georgia, Insulin resistance and vascular dysfunction in the cerebral circulation. September, 2004. Department of Physiology, University of Heidelberg, Germany, Effects of insulin resistance on the cerebral circulation. September, 2004. Department of Physiology, University of Szeged, Hungary, Novel approaches to brain protection against ischemic injury. October, 2004. Plenary speaker, Korean Physiological Society, New approaches to neuroprotection. November, 2004. Department of Physiology and Biophysics, University of New York at Stony Brook, Symposium on Diabetes and its Complications, Cerebral vascular dysfunction in insulin resistance.

January, 2005. Symposium speaker, Winter Brain Research Conference, Reactive oxygen species as signaling molecules in the cerebral circulation. March, 2005. Symposium speaker, IUPS meeting, Rosuvastatin improves cerebrovascular function in insulin-resistant Zucker obese rats by the inhibition of NAD(P)H-oxidase-dependent superoxide anion production. July, 2005. Symposium speaker, British Pharmacological Meeting, Rosuvastatin reduces superoxide anion production and improves cerebrovascular function in Zucker obese rat.


(Revised 1/11/16)

October, 2005. Department of Physiology, University of Szeged, Szeged, Hungary. Mitochondrial potassium channels and neuroprotection. December, 2005. Hypertension Center, Wake Forest University Health Sciences. Statins and vascular dysfunction in insulin resistance. January, 2006. Symposium Speaker, Winter Brain Research Conference, Steamboat Springs, CO. Cerebral vascular dysfunction in insulin resistance. April, 2006. Symposium Organizer and Chair, Don Reis Memorial Session, EB2006, San Francisco, CA.

June, 2006. Invited Participant and Discussion Leader for NINDS Conference on Cell Biology of Vascular Cognitive Impairment, Bethesda, MD.

August, 2006. Invited Participant for Gordon Conference on Cerebral Blood Flow and Metabolism, Oxford, England.

October, 2006. Symposium Speaker, International Conference on Insulin Resistance, Las Vegas, NV.

October, 2006. Department of Pharmacology and Therapeutics, University of Florida School of Medicine. Detrimental effects of insulin resistance on the heart and vasculature: What you don’t know may hurt you! October, 2006. Department of Physiology, University of Indiana Medical School. Adverse effects of insulin resistance on the cerebral circulation. January 2007. Department of Physiology, University of Louisville Medical School, Adverse Effects of Insulin Resistance on the Brain and Heart Vasculature: What you don’t know will hurt you! January, 2007. Molecular and Cellular Pathobiology Program, Protective role of mitochondrial ATP-sensitive potassium channels in protecting the brain against lethal stress. January, 2007. Department of Cell Biology and Anatomy, Louisiana State U. Medical Center—Shreveport, Detrimental effects of insulin resistance on the brain and cerebral circulation. March, 2007. Medical College of Georgia, Augusta, GA, Adverse effects of insulin resistance on the cerebral circulation and brain. What you don’t know will hurt you! March, 2007. Temple University School of Medicine, Philadelphia, PA, Detrimental effects of insulin resistance on the brain and heart vasculature: What you don’t know may hurt you! April, 2007. University of Minnesota School of Medicine, Minneapolis, MN, Detrimental effects of insulin resistance on the brain and heart vasculature: What you don’t know may hurt you! April, 2007. Symposium Speaker and Organizer, Experimental Biology 2007, Washington, D.C., Mitochondrial Mechanisms in Cerebrovascular Function in Health and Disease.

July, 2007. Symposium Speaker, Life Sciences 2007, Glasgow, Scotland, Cerebrovascular Function: Changes in Health and Disease. October, 2007. Department of Physiology, Semmelweis Medical School, Budapest, Hungary, Mitochondrial effects on the neurovascular unit.


(Revised 1/11/16)

October, 2007. Department of Physiology, Debrecen Medical School, Debrecen, Hungary, Mitochondrial KATP and neuroprotection. November, 2007. Eastern Virginia Medical School, Norfolk, VA, Detrimental effects of insulin resistance on the cerebral circualation: What you don’t know will hurt you. March, 2008. Department of Physiology and Biophysics, University of Tennessee Medical School, Memphis, TN, Mitochondrial influences on cerebral blood vessels and brain: preconditioning and vasodilation. March, 2008. Department of Physiology, Loyola-Chicago College of Medicine, Chicago, IL, Mitochondrial influences onbrain and cerebral blood vessels: preconditioning and vasodilation. March, 2008. Department of Physiology, Southern Illinois University, Carbondale, IL , Detrimental effects of insulin resistance on the cerebral circualation: What you don’t know will hurt you. April, 2008. Department of Anatomy, East Carolina Medical School, Greenville, NC, Detrimental effects of insulin resistance on the cerebral circulation: What you don’t know will hurt you. July, 2008. Department of Physiology, Wayne State University, Detroit, MI, Mitochondrial influences on brain and cerebral blood vessels: preconditioning and vasodilation. August, 2008. Invited Speaker, 25th Conference of the European Society on Microcirculation, Budapest, Hungary. Mitochondrial influences on cerebral vascular tone in health and disease. July, 2008. Department of Physiology, Pharmacology, and Neuroscience, University of South Carolina, Columbia, SC, Mitochondrial effects on the neurovascular unit. September, 2008. Department of Physiology and Pharmacology, University of Toledo School of Medicine, Toledo, OH, Detrimental effects of insulin resistance on the cerebral circualation: What you don’t know will hurt you. September, 2008. Neuroscience Graduate Progream, Wake Forest University Health Sciences, Winston-Salem, NC, Mitochondrial influences on brain and cerebral blood vessels: preconditioning and vasodilation. February, 2009. Pulmonary Medicine Division, University of Illinois-Chicago, Chicago, IL, Detrimental effects of insulin resistance on the cerebral circulation: What you don’t know will hurt you. July, 2009. Invited Speaker, International Cerebral Blood Flow and Metabolisms Meeting, Chicago, IL, Alterations in mitochondrial influences on cerebral arterial responsiveness in insulin resistance. July, 2009. Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, Mitochondrial influences on brain: neuroprotection and vasodilation in health and disruption by insulin resistance.

July, 2009. School of Pharmacy, University of Minnesota, Minneapolis, MN. Mitochondrial influences on brain: neuroprotection and vasodilation in health and disruption by insulin resistance.


(Revised 1/11/16)

October, 2009. Invited Speaker, Society for Neurotoxicology, Chicago, IL. Mechanisms of neuroprotection. November, 2009. Department of Physiology, Semmelweis Medical School, Budapest, Hungary, Mitochondrial activation and cerebral vascular tone.

November, 2009. Department of Bioinformatics, University of Szeged Medical School, Szeged, Hungary, Mitochondrial influences on brain: neuroprotection and vasodilation in health and disruption by insulin resistance. January, 2010. Invited Speaker, Winter Brain Research Meeting, Breckinridge, CO, Mitochondrial mechanisms in cerebral vascular control. July, 2010. Departments of Physiology and Pharmacology, University of Alberta, CA, Mitochondrial influences on the cerebral circulation during health and disease. July, 2010. Speaker, 6th World Congress of Basic and Clinical Pharmacology, Copenhagen, Denmark, Mitochondrial mediated vasodilation and insulin resistance. September, 2010. Invited Speaker, World Congress for Microcirculation, Paris, France, Role of mitochondria in the vasomotor responses of cerebral arteries. April, 2011. Symposium organizer, Experimental Biology 2011, Washington, D.C., Mechanisms of mitochondrial-mediated cardiovascular dysfunction and the application of organelle-specific therapies in the metabolic syndrome.

May, 2011. Invited Speaker, Brain 2011, Barcelona, France, Mitochondrial Depolarization Alone Enhances Calcium Sparks Generation Independent of ROS in Cerebral Arteries. November, 2011. Featured Speaker, Japanese Society of Cerebral Blood Flow and Metabolism (23rd Annual Meeting), Tokyo, Japan, Mitochondrial mechanisms in the brain and cerebral circulation: Neuroprotection and Vasodilation. November, 2011. Featured Speaker, Japanese Society of Cerebral Blood Flow and Metabolism (23rd Annual Meeting), Tokyo, Japan, Novel Approaches to protect the brain and cerebral vasculature during and after stroke.

March, 2012. Invited Speaker, 75th Anniversary of Albert Szent-Györgyi’s Nobel Prize, Szeged, Hungary, Mitochondrial Mechanisms in Health and Disease.

September, 2012. Department of Physiology and Pharmacology, University of Missouri Medical School, Columbia, MO, Mitochondrial Influences on Cerebral Vascular Tone in Health and Disease. September, 2012. Department of Pharmaceutics, North Dakota State University, Fargo, ND, Mitochondrial influences on the cerebral vasculature during health and disease. October, 2012. Keynote Speaker, 2012 Reynolds Oklahoma Center on Aging Symposium, University of Oklahoma, Oklahoma City, Oklahoma, Mitochondrial influences on the cerebral circulation during health, disease, and aging. October, 2012. Invited Speaker, Trans-Pacific Workshop on Stroke 2012, New Orleans, LA, Mitochondrial influences on the cerebral vasculature during health and disease. March, 2013. Department of Anatomy and Cell Biology, Greenville, NC, Cerebral vascular control mechanisms in health and disease.


(Revised 1/11/16)

March, 2013. Department of Pharmacology and Therapeutics, University of Mississippi, Jackson, MS, Mitochondrial mechanisms in cerebral vascular control in health and disease. May/June, 2013. Keynote Speaker, 7th Gulf Coast Physiological Society Meeting, Mobile, AL, Regulation of the cerebral circulation. October, 2013. Invited presentation, Vascular Biology 2013, Cape Cod, MA, Enhanced mitochondrial-induced cerebral dilation after ischemia in rats.

May, 2014. Distinguished Invited Lecturer, University of California—Los Angeles, CA, Mitochondria mechanisms on cerebral vascular tone in health and disease.

April, 2015. Invited Speaker, Experimental Biology 2015, Boston, MA, Resilient mitochondrial mechanisms in endothelium following ischemia.

May, 2015. Department of Pharmacology, University of Tennessee-Memphis, Memphis, TN. Mitochondrial influences on the cerebral vasculature in health and disease. May, 2015. Plenary Speaker, 79th Meeting of the Hungarian Physiological Society and Hungarian Microcirculatory and Vascular Biology Society, Szeged, Hungary. Resilient mitochondrial mechanisms in endothelium following ischemia. June, 2015. Invited Speaker, 8th European Biology Organization (EVBO), Pisa, Italy, Mitochondrial regulation of vascular function: beyond ATP production. October, 2015. Department of Pharmacology, University of Vermont, Burlington, Vermont. Mitochondrial dynamics in the cerebral vasculature.

GRADUATE STUDENTS/RESIDENTS/FELLOWS ADVISED: FELLOWS TRAINED:

1986-1987 Massroor Pourcyrous, M.D. 1986-1990 William M. Armstead, Ph.D. (with Dr. C.W. Leffler) Individual NIH and AHA Post-Doctoral Fellowships 1988-1990 Masaaki Shibata, D.V.M., Ph.D. 1988-1990 Oliver Thelin, M.D. 1990-1992 Jing Chen, M.D., M.S. 1992-1994 David Colonna, M.D. 1992-1994 Wei Meng, M.D. 1994-1995 Efren C. Aganon, M.D. 1995-1996 Robert Errico, M.D. 1992-1996 Clara Thore, Ph.D. 1997-1999 Roland Veltkamp, M.D. Stroke Center Fellowship 1997-1999 Ferenc Domoki, M.D./Ph.D. Zoltán Magyari Fellowship, OTKA Fellowship 1998-2001 James Perciaccante, M.D. 1998-2001 Katsuyoshi Shimizu, M.D./Ph.D. 2000-2003 Zsombor Lacza, M.D./Ph.D. Eotvos Fellowship OTKA Fellowship Young Investigator Award in Brain Research, 2003


(Revised 1/11/16)

2001-2003 Takashi Horiguchi, M.D./Ph.D. 2001-2006 Bela Kis, M.D./Ph.D. JSPS Fellowship 2001-2004 Benedek Erdos, M.D./Ph.D. Eotvos Fellowship Microcirculatory Society Young Investigator Award 2001-2003 James Jordan, Ph.D. Individual NIH Post-Doctoral Fellowship 2003-2004 Steve Simandel, Ph.D. 2003-2009 Prasad Katakam, M.D./Ph.D. AHA Post-Doctoral Fellowship 2004-2006 Gabor Lenszer, M.D./Ph.D. European Neuroscience Society Travel Award 2004-2008 Keita Mayanagi, M.D. 2006 Donald Reis APS Award 2004-2009. Tamas Gaspar, M.D./Ph.D. 2007-2008 Laura Lenti, M.D./Ph.D. 2008-2010 Adam Institoris, M.D./Ph.D. 2008-2011 Mesia Steed, Ph.D. NIH Minority Supplement Fellowship 2010-2012 Edina Wappler, M.D./Ph.D. 2011-2012 Paige Katz, Ph.D. 2012-present Rutkai Ibolya, Ph.D. APS 2013 Clinical Science Young Investigator Award

AHA Postdoctoral Fellowship Young Scientist Travel Award from ASPET 2015 Postdoctoral Fellow Travel Award from Office of Graduate Studies

2014-2015. Tünde Tőkés, Ph.D. 2014-present Ivan Merdžo, M.D.

VISITING FACULTY: 1994-1996 Thomas M. Louis, Ph.D.; Professor, East Carolina Medical School 1995-1997, 1998-1999 Ferenc Bari, Ph.D.; Associate Professor, Albert Szent-Györgyi 2003 Fulbright Fellowship Medical University (now called The University of Szeged), 2006 Szeged, Hungary 1996-1997 Rozsa Degi, M.D./Ph.D., Assistant Professor, Albert Szent- Györgyi Medical University, Szeged, Hungary 1997-1999, 2000, Ferenc Domoki, M.D., Ph.D.; Assistant Professor, Albert 2006-2008 Szent-Györgyi Medical University, Szeged, Hungary


(Revised 1/11/16)

GRADUATE STUDENTS TRAINED: 1992-1994 Martino Nam, M.S., D.V.M.--received Ph.D.

Graduate School Fellowship 1995-1997 Tracy Beasley, M.S.--received Ph.D.

Graduate School Fellowship Sulkin Award for Excellence in Research, 1996

1999-2004 Nishadi Thrikawala, B.A. –received Ph.D. Graduate School Fellowship Mary Bell Excellence in Research Award 1996-2001 Rozsa Degi, M.D.--received Ph.D. 1997-2001 Ferenc Domoki, M.D.--received Ph.D. 2002-2003 Eszter Horvath, visiting M.D./Ph.D. student 2002-2003 Krisztina Nagy, M.S.– visiting Ph.D. student 2007-2007 Eva Mracsko, visiting M.D./Ph.D. student 2011-2015 Somhrita Dutta, B.S.—received Ph.D. Jean Yocum Harlan Award for Outstanding Student Presentation 2013 2012-2012 Cristina Cavalho, visiting student from Portugal

david william busija, m.a., ph.d., m.d. (hon)€¦ · stroke in stroke-prone spontaneously...

Documents