1 | Company Confidential

The Xcellerate® Value Proposition

Study starts in 2008–2012 (2,215 industry protocols, 5 Covance client protocols)

Better sites Faster enrollment

Lower cost

2 | Company Confidential

Personalized Medicine

On average, drugs fail in 25-60% of patients

Antidepressants 38% Asthma Drugs 49% Diabetes Drugs 43% Arthritis Drugs 50% Alzheimer’s Drugs 70% Cancer Drugs 75%

Percentage of Patients for Whom Class of Drug is Ineffective

3 | Company Confidential

Operational Monitoring – Risk Scoring

4 | Company Confidential

Operational Monitoring – Recommendations

5 | Company Confidential

Operational Monitoring – Trending by Factor

6 | Company Confidential

Operational Monitoring – Site Trends

7 | Company Confidential

Operational Monitoring – Site Specific Scores

8 | Company Confidential

Medical Review – Potential Safety Signal

9 | Company Confidential

Medical Review – Longitudinal View

10 | Company Confidential

Medical Review – by Sub Group