cyclic amp
TRANSCRIPT
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Vydehi veeramallaFinal yr pgDepartment of Biochemistry
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CONTENTS
CELL SIGNALLING
TYPES OF SECOND MESSENGERS
CHARECTERISTICS OF SECOND MESSENGERS
HORMONES ACTING THROUGH CYCLIC AMP
MECHANISM OF ACTION OF CYCLIC AMP
EFFECTS OF CYCLIC AMP
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HISTORYEarl Wilbur Sutherland Jr. – 1971 Nobel Prize in
Physiology or Medicine
Epinephrine – liver - glycogen to glucose – cAMP
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INTRODUCTION
Cyclic AMP is a cyclic nucleotide
Chemically it is a 3’5’ adenosine monophosphate
It is synthesized in tissues from ATP under influence of ADENYLYL CYCLASE in presence of Mg ion
Degraded to 5’AMP in by Phosphodiesterase
It is a Second Messenger
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cell signaling- 3 processes
A series of signaling events that mediate the response to each stimulus.
specific
amplified
regulated
coordinated.
receptors plasma membrane , cytoplasm or nucleus.
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Second Messengers
cAMP pathway
cGMP pathway
IP3 / DAG pathway
Calcium as a second messenger
Eicosanoids
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Second Messengers
General characteristics1) Low amounts in resting state
2) Regulated synthesis
3) Regulated destruction
4) Act through other proteins
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hCGLHFSHLPH PTHCALCITON
IN
Epinephrine (β1,β2)NorepinephrineGlucagonCRHACTHMSH TSH
1.Somatostatin
2.Acetylcholine M2
3.Angiotensin II
4.Epinephrine α2
ATIVATE ADENYLYL CYCLASE
INHIBIT ADENYLYL CYCLASE
AVP/ADH
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G Protein-Linked Receptors
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G-PROTEIN COUPLED RECEPTOR
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tes
Activation of G Proteins
AC
ADENYLYL CYCLASE
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G PROTEIN ACTIVATES ADENYLYL CYCLASE
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Cyclic AMP
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PROTEIN KINASE A - ACTIVATION
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EFFECTS OF CYCLIC AMP1. ALTERED GLYCOGEN METABOLISM BY ENZYME REGULATION
2. ALTERED GENE TRANSCRIPTION
3. HORMONE ESTRADIOL SECRETION
4. ALTERED ION TRANSPORT - HCL SECRETION IN STOMACH
5. WATER REABSORPTION BY ANTI DIURETIC HORMONE
6. CAFFEINE – PHOSPHODIESTERASE INHIBITORS
7. DRUGS – SALBUTAMOL , THEOPHYLLINE
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ENZYME REGULATION
GSD VIII,IX GSD X
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GENE TRANSCRIPTION
TRANSCRIPTION FACTOR COACTIVATOR
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ESTRADIOL SECRETION
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STOMACH - HCL SECRETION
HISTAMINE
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KIDNEY - WATER REABSORPTION
ANTIDIURETIC HORMONE
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PHOSPHODIESTERASE INHIBITORS
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EPINEPHRINE NOREPINEPHRINE SALBUTAMOL
DRUGS
THEOPHYLLINEPDE
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Summary
Cyclic amp is a mediator of hormone actionSecond messengerActivates protein kinase A
Causes glycogenolysis Causes lipolysisModulates TranscriptionActivates Hormone secretionIncreases gastric secretionRegulates cell permeability to water
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