CVRGCVRG

Presenter Disclosure InformationPresenter Disclosure Information

Joel Saltz MD, PhDJoel Saltz MD, PhDDirector Comprehensive Informatics CenterDirector Comprehensive Informatics CenterEmory UniversityEmory University

Translational Research Informatics and CVRGTranslational Research Informatics and CVRG

FINANCIAL DISCLOSURE:FINANCIAL DISCLOSURE:NoneNone

UNLABELED/UNAPPROVED USES DISCLOSURE:UNLABELED/UNAPPROVED USES DISCLOSURE:NoneNone

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CVRGCVRG

Translational Research Informatics Gender Ethnicity Age Weight Diagnosis Medical History

Literature Databases Terminologies Ontologies Lab Tests

Genes Proteins

Biological Models Technologies Algorithms

Integration, Management, Analysis, and Dissemination

Integration, Management, Analysis, and Dissemination

CVRGCVRG

Translational Research Continuum

SNPIdentification

SNPIdentification

ClinicalData

Correlation

ClinicalData

Correlation

ExpressionAnalysis

ExpressionAnalysis

TissueBankingTissue

Banking

StudyCreation

StudyCreation

PatientEnrollment

PatientEnrollment

ClinicalData

Collection

ClinicalData

Collection

ImageSharing &Analysis

ImageSharing &Analysis

Slide from Ken Buetow

CVRGCVRG

Transcontinental Railway: The Golden Spike - Triumph of Standards

CVRGCVRG

Translation: Same ideas, different words

CVRGCVRG

Biomedical Informatics Services

• Security• Semantic interoperability – common vocabulary and meaning• Data structure interoperability• Interoperability with existing standards for clinical and imaging

systems (e.g. HL-7, DICOM)• Ability to compose services to create application• Ability to efficiently invoke high end computing services• Coordinated query to obtain data from many datasources

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CVRGCVRG

Biomedical Grid Organizations

CVRGCVRG

Distinguishing Informatics Aspects of CVRG

• Annotation, markup and query of time dependent imagery• Electrophysiology• ECG: grid based data storage, query and analysis• Cardiac research related semantics

CVRGCVRG

caBIG Organization Structure

Architecture

Vocabulary & Common

Data Elements

General ContractorGeneral Contractor

Strategic Working GroupsStrategic Working Groups

Clinical TrialsIntegrative Cancer Research

Tissue Banks & Pathology Tools

caBIG OversightcaBIG Oversight

Imaging

Open to all, not just funded participants.Open to all, not just funded participants.

190 institutions, 2000 people involved thus far190 institutions, 2000 people involved thus far..

CVRGCVRG

caBIG Middleware: caGrid

caGrid Components• Advertisement and Discovery• Workflow• Security (GAARDS)• Language (metadata,

ontologies)• Grid Service Graphical

Development Toolkit (Introduce)

• Wrapping executables (gRavi)• Efficient Bulk Data Transport

(IVI middleware)• DICOM compatability (IVI

middleware)

CVRGCVRG

caGrid Service

caGrid Service

Common Application Services

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caGrid Service

MRI/CT Images

DICOM/AIM Model

CVRG GridInfrastructure

caGrid Service

Taqman Data

JHU SNP Model

caGrid Service

ECG XML

HL7 aECG Model

caGrid Service

Physionet WFDB

WFDB Metadata Model

caGrid Service

OpenClinica Data

OpenClinica Model

caGrid Service

ProteinDB Data

ProteinDB Model

PhysionetAlgorithms

Berger QTAlgorithm

CVRGCVRG

CVRG Challenge: Temporal Data

• ECG, Cardiac MRI, Multi-slice Cardiac CT, Cardiac PET/CT, Nuclear Perfusion Imaging …

• Analysis and integration of cardiac electrical, mechanical activity, perfusion and hemodynamics

• Temporal query and analysis across patient populations• Integration with clinical and “omic” data