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    Patients BackgroundPersonal Data

    Name of Patient: Mr. X

    Age: 64 y/o

    Status: Married

    Sex: Male

    Admitting Diagnosis :T/C Sepsis S/S CVA

    Final Diagnosis :CVA ( Cerebrovascular Accident)

    Past Medical History :Hypertension, DM Type II

    Vital Signs :BP = 130/80 ; PR = 72 ; RR = 22 ;

    T = 37.5 C

    Brief History:

    The patient has been bedridden since he had stroke last April 2007, he also

    had difficulty in swallowing and have a necrotic ulceration at the sacrum and

    olecranon prior to admission. Mr. Ex-Men had a sedentary lifestyle, he loves eating

    fatty foods and food with high calories, he also have a family background on

    hypertension. He only stays at home and doesnt exercise. In 1987, he also had

    stroke due to hypertension, but didnt take any maintenance drug after that. He

    only takes Calcibloc 10mg, whenever he feels the signs and symptoms ofhypertension.

    Review of Systems

    - Physical Assessment

    Vital signs : T 37.5 C PR 72 RR 22 BP 130/80

    Consciousness : obtunted open eyes, responds slowly, confused

    Bed-ridden

    Hemi paresis - left side of the body

    Wt: 47 kgs. Ht: 5 5

    Weight ( loss [+] gain [ - ] ) Fever [ - ] Night Sweats [ - ]

    Significance: weight loss of about 4-5 kgs.

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    SKIN

    Change in color [ - ] , Ulcers [ + ] ,Rashes [ - ] , Pruritus [ - ] , Bruising

    [ - ] ,

    Nevi ( change in color [ - ] / shape [ - ] / size [ - ] )

    Significance: Sacrum - stage 3 decubitus ulcer (ulcer extends to

    subcutaneous fat layer) , Olecranon process of ulna stage 2 decubitus

    ulcer (skin is broken to epidermis, abrasion and blister present)

    Oxygen is given via nasal canula at 2-3 lpm to deliver more oxygen to

    blood

    enhance wound healing

    HEAD

    Headache [ - ] , Injury [ - ] , Tenderness [ - ]

    Hair & scalp condition ( infection/ infestation) [ - ], texture silky [ - ] ,

    oily [ + ]

    Significance: oily hair need to improve hygiene

    EYES

    Change in visual field [ - ] , Glasses [ - ] , Diplopia [ - ] , Inflammation [

    - ] ,

    Discharge [ - ]

    Significance: none

    NOSE

    Allergies [ - ] , Sinus problem [ - ] , Obstruction [ - ] , Polyps [ - ] ,

    Discharge [ - ], Epistaxis [ - ]

    Significance: none

    Throat

    Toothaches [ - ] , Loose teeth [ - ] , Dentures [ - ] , Bleeding gums [ - ] ,

    Mouth sores [ - ] , Difficulty in swallowing [ + ] , Ulceration or lesion on

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    tongue, gums, buccal mucosa [ - ]

    Significance: NG tube feeding

    Respiratory

    Chest pain [ - ] , Dyspnea [ + ] , Cough [ - ] , Amount and color of

    sputum

    [ - ] , Hemoptysis [ - ]

    Significance: Ventilation machine

    Oxygen is given via nasal canula at 2-3 lpm to ease labored breathing

    Cardiovascular

    Chest pain / pressure / tightness [ - ] , Orthopnea [ + ] , Claudication [ -

    ]

    Significance: Bed reclined to ease breathing

    Gastro-Intestinal

    Dysphagia( solid & fluid ) [ + ] , Ulcer [ - ] , GERD [ + ] , Indigestion [ - ]

    ,

    Diarrhea, Constipation [ - ] , Blood in stool [ - ] , Hemorrhoids [ - ],

    Jaundice [ - ]

    Significance: NG tube feeding

    Genito-Urinary

    Dysuria / Hematuria / Nocturia [ - ] , UTI [ - ] , Incontinence [ +/- ]

    Significance: Bed reclined to ease breathing

    Endocrine

    Heat / Cold tolerance [ - ] , Weight change [ + ] , Polydisia [ - ] ,

    Polyuria [ - ] ,

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    Polyphagia [ - ]

    Significance: Weight loss of about 4-5 kgs.

    Musculo-Skeletal

    Limitation of movement [ + ] , Stiffness [ - ] , Joint swelling/redness [ - ]

    ,

    Arthritis [ - ] , Muscle spasm [ - ] , Muscle weakness [ + ]

    Significance: Hemi paresis left side of the body

    Psychiatric

    Mood change [ - ] , Anxiety [ - ] , Suicidal thoughts/ attempts [ - ]

    Significance: none

    Laboratory Results

    Hematology Report

    Normal Values Results

    emoglobin M 140 170 g/LF 120 160 g/L

    96

    ematocrit M 0.42 0.52F 0.37 0.470.28

    ed Blood Cells Count (RBC) M 4.5 5.5 x 1012/LF 4.0 5.2 1012/L

    2.73

    hite Blood Cells Count (WBC) 4 10 x 109/L 15.5

    atelet Count 150 400 x 109/L 395

    hers:

    fferential Count

    gmenters 0.50 0.70 0.93

    ymphocytes 0.20 0.40 0.05

    onocytes 0.02 0.07 0.02

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    Clinical Chemistry Report

    Normal Values R

    Creatinine B2 M 80 115 umol/LF (53-97)

    1

    SGPT B2 0 41 u/L 5

    Total CHON B2 65 80 g/L 6

    Albumin B2 35 50 g/L 3

    Globulin B2 15 35 g/L 3

    Cholesterol B2 3.6 6.5 mmol/L 2

    Triglycerides B2 0.4 1.86 mmol/L

    HDL B2 > 0.90 mmol/L 0

    LDL B2 < 3.4 mmol/L

    VLDL B2 0.18 0.84mmol/L 0

    DRUG STUDY

    NAME OF DRUG/

    GENERIC NAME

    INDICATION AND

    DOSAGE

    ACTION SIDE EFFECTS

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    Name of Drug:

    TAZOCINCommon Name:

    2.25 g vial

    Piperacillin Na 2 g

    Tazobactam Na 250 mg4.5 g vial

    Piperacillin Na 4 g

    Tazobactam Na 500 mg

    Indication:

    Treatment of Systemic andor local bacterial

    infections caused by

    sensitive organisms;

    UTI, lowerrespiratory tract,

    intra-abdominal; skin

    and skin structureinfections; bacterial

    septicemia;

    polymicrobicinfections.

    Dosage:

    Adult & Children > 12yr.

    2.25-4.5 g/day 6-8

    hours or 12 hourly byIM or IV infusion

    (.20-30 min)

    Penicillins are usually

    bactericidal in action.They bind reversibly

    to several enzymes

    outside the bacterial

    cytoplasmicmembrane. These

    enzymes, known as

    penicillin-bindingproteins (PBPs) are

    involved in cell-wall

    synthesis and celldivision.

    Interference with

    these processes

    inhibits cell-wall

    synthesis, causingrapid destruction of

    the cell.

    Diarrhea, constipation,

    nausea, headache,insomnia, rash,

    erythema, pruritus

    vomiting, allergic

    reactions, urticariaand super infection

    NAME OF DRUG/

    GENERIC NAME

    INDICATION AND

    DOSAGE

    ACTION SIDE EFFECT

    Name of Drug:

    DUAVENT

    Common Name:Per 2.5 ml pulmoneb

    Ipatropium Br 500 mcg

    Salbutamol sulfate 2.5mg

    Indication: Bronchodilator

    for treatment of

    bronchospasmassociated with

    COPD, including

    chronic bronchitis,emphysema and

    asthma

    Dosage:

    1-2 pulmoneb every 6-8hours

    Inhibits vagally mediated

    reflexes by

    antagonizingacetylcholine

    CNS nervousness,

    dizziness, head

    Cardiovascular palpitations

    EENT blurred visio

    epistaxisGI nausea, GI distr

    dry mouth

    Respiratory cough,

    respiratory tracinfection, bronc

    bronchospasm

    Skin - rash

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    NAME OF DRUG/

    GENERIC NAME

    INDICATION AND

    DOSAGE

    ACTION SIDE EFFECTS

    Name of Drug:

    AEKNILCommon Name:

    Paracetamol

    Indication:

    Pyrexia of unknown origin.Fever and pain

    associated with

    common childhooddisorders, tonsillitis,

    upper respiratory tract

    infections, postimmunization

    reactions, after

    tonsillectomy andother conditions.

    Prevention of febrileconvulsion.

    Headache, cold,sinusitis, muscle pain,

    arthritis and

    toothache.Dosage:

    2-3ml depending on the

    severity of case, dosemay be repeated 4

    hourly. In severe of

    cases, dose may beadministered by IVvery slowly

    May produce analgesic

    effect by blockingpain impulses by

    inhibiting

    prostaglandin or painreceptors sensitizers.

    May relieve fever by acting

    in hypothalamus heat-regulating center

    Hematologic hemo

    anemia, neutropleucopenia,

    thrombocytope

    Hepatic liver dama(with toxic dos

    jaundice

    Metabolic

    hypoglycemia

    Skin rash, urticaria

    Anatomy & Physiology

    Lobes of the Brain

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    The manifestations of stroke depend on which region and the extent of brain

    affected.

    The three main components of the brain:

    Cerebrum - the largest and most developmentally advanced part of the

    human brain. It is responsible for several higher functions, including higher

    intellectual function, speech, emotion, integration of sensory stimuli of all

    types, initiation of the final common pathways for movement, and fine control

    of movement.

    Cerebellum - second largest area, is responsible for maintaining balance and

    further control of movement and coordination.

    The brain stem is the final pathway between cerebral structures and the

    spinal cord. It is responsible for a variety of automatic functions, such as

    control of respiration, heart rate, and blood pressure, wake-fullness, arousal

    and attention.

    Cerebrum is divided into a right and a left hemisphere and is composed of

    pairs of frontal, parietal, temporal, and occipital lobes.

    The left hemisphere controls the majority of functions on the right side of the

    body, while the right hemisphere controls most of functions on the left side of

    the body The crossing of nerve fibers takes place in the brain stem. Thus,

    injury to the left cerebral hemisphere produces sensory and motor deficits on

    the right side, and vice versa.

    Cerebellum and Brainstem

    A stroke involving the cerebellum may result in a lack of coordination,

    clumsiness, shaking, or other muscular difficulties. These are important to

    diagnose early, since swelling may cause brainstem compression or

    hydrocephalus

    Strokes in the brainstem are usually due to basilar occlusion, although in

    many cases the clinical syndrome may fit the criteria for a lacunar stroke.

    Brainstem strokes can be serious or even fatal. People who survive may be

    left with severe impairments or remain in a vegetative state.

    Major Blood Vessels

    Normal function of the brain's control centers is dependent upon adequate

    supply of oxygen and nutrients through a dense network of blood vessels.

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    Blood is supplied to the brain, face, and scalp via two major sets of vessels:

    the right and left common carotid arteries and the right and left vertebral

    arteries.

    The common carotid arteries have two divisions.

    The external carotid arteries supply the face and scalp with blood.

    The internal carotid arteries supply blood to the anterior three-fifths of

    cerebrum, except for parts of the temporal and occipital lobes.

    The vertebrobasilar arteries supply the posterior two-fifths of the cerebrum,

    part of the cerebellum, and the brain stem.

    Any decrease in the flow of blood through one of the internal carotid arteries

    brings about some impairment in the function of the frontal lobes. This

    impairment may result in numbness, weakness, or paralysis on the side of

    the body opposite to the obstruction of the artery. Occlusion of one of thevertebral arteries can cause many serious consequences, ranging from

    blindness to paralysis.

    Circle of Willis

    At the base of the brain, the carotid and vertebrobasilar arteries form a

    circle of communicating arteries known as the circle of Willis.

    From this circle other arteries -- the anterior cerebral artery (ACA), the

    middle cerebral artery (MCA), the posterior cerebral artery (PCA) - arise and

    travel to all parts of the brain. Posterior Inferior Cerebellar Arteries (PICA),which branch from the vertebral arteries, are not shown.

    Because the carotid and vertebrobasilar arteries form a circle, if one of

    the main arteries is occluded, the distal smaller arteries that it supplies can

    receive blood from the other arteries (collateral circulation).

    Anterior Cerebral Artery

    The anterior cerebral artery extends upward and forward from the

    internal carotid artery. It supplies the frontal lobes, the parts of the brain that

    control logical thought, personality, and voluntary movement, especially the

    legs. Stroke in the anterior cerebral artery results in opposite leg weakness.

    If both anterior cerebral territories are affected, profound mental symptoms

    may result (akinetic mutism).

    Middle Cerebral Artery

    The middle cerebral artery is the largest branch of the internal carotid.

    The artery supplies a portion of the frontal lobe and the lateral surface of the

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    temporal and parietal lobes, including the primary motor and sensory areas

    of the face, throat, hand and arm and in the dominant hemisphere, the areas

    for speech. The middle cerebral artery is the artery most often occluded in

    stroke.

    Posterior Cerebral Artery

    The posterior cerebral arteries stem in most individuals from the basilar

    artery but sometimes originate from the ipsilateral internal carotid artery.

    The posterior arteries supply the temporal and occipital lobes of the left

    cerebral hemisphere and the right hemisphere.

    When infarction occurs in the territory of the posterior cerebral artery, it

    is usually secondary to embolism from lower segments of the vertebral

    basilar system or heart.

    Clinical symptoms associated with occlusion of the posterior cerebralartery, depend on the location of the occlusion and may include thalamic

    syndrome, thalamic perforate syndrome, Weber's syndrome, contralateral

    hemiplegia, hemianopsia and a variety of other symptoms, including color

    blindness, failure to see to-and-fro movements, verbal dyslexia, and

    hallucinations. The most common finding is occipital lobe infarction leading to

    an opposite visual field defect.

    Lenticulostriate Arteries

    Small, deep penetrating arteries known as the lenticulostriate arteries

    branch from the middle cerebral artery Occlusions of these vessels orpenetrating branches of the circle of Willis or vertebral or basilar arteries are

    referred to as lacunar strokes. About 20% of all stokes are lacunar and have a

    high incidence in patients with chronic hypertension and in the elderly CT

    scanning shows signs of infarction in only approximately half of the most of

    the common form of lacunar stroke (pure motor stroke), but MRI has

    increased the yield

    Pathophysiology

    1.Disruption of blood to a part of the brain

    2.Oxygenation of Neurons reduced

    3.Anaerobic glycolysis

    4. Sodium pump & neurotransmitter fail

    5. Cerebral edema

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    6. Cerebral blood Vessel walls swell; Circulation is compromised and vasospasm

    combined with blood viscosity reduced cerebral perfusion

    7. Outcomes of decreased cerebral perfusions: cerebral anoxia; cerebral

    infarction; contralateral deficits; permanent deficit

    Types of Stroke:

    (1) Ischemic Stroke

    Transient ischemic Stroke (TIA) - is a short-term stroke that lasts for less

    than 24 hours. The oxygen supply to the brain is restored quickly, and

    symptoms of the stroke disappear completely. A transient stroke needs

    prompt medical attention as it is a warning of serious risk of a major stroke

    Cerebral thrombosis occurs when a blood clot (thrombus) forms in an

    artery (blood vessel) supplying blood to the brain. Furred-up blood vessels

    with fatty patches of atheroma (arteriosclerosis) may make a thrombosismore likely. The clot interrupts the blood supply and brain cells are starved of

    oxygen.

    Cerebral embolism is a blood clot that forms somewhere in the body

    before travelling through the blood vessels and lodging in the brain. This

    causes the brain cells to become starved of oxygen. An irregular heartbeat or

    recent heart attack may make you prone to forming emboli.

    http://www.netdoctor.co.uk/diseases/facts/atherosclerosis.htmhttp://www.netdoctor.co.uk/diseases/facts/coronarythrombosis.htmhttp://www.netdoctor.co.uk/diseases/facts/atherosclerosis.htmhttp://www.netdoctor.co.uk/diseases/facts/coronarythrombosis.htm
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    (2) Hemorrhagic Stroke - occurs when a blood vessel bursts inside the brain andbleeds (hemorrhages). With a hemorrhage, extra damage is done to the brain tissue

    by the blood that seeps into it..

    Signs and Symptoms of CVA

    Altered consciousness or unconsciousness

    stertorous breathing

    Unequal pupils ( larger pupil noted on same side as stroke)

    Paralysis of one side

    Perspiration

    Aphasia (abnormal or absent of speech)

    Blank stare

    Dysphagia

    Inability make decisions

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    Loss of memory

    Gait instability