CV ( Michael S. DuBow)

Professor & Director (International Relations)

Institute for Integrative Biology of the Cell (I2BC)

CEA, CNRS UMR 9198, Univ. Paris-Saclay

Universite Paris-Sud, Bâtiment 409

91405 ORSAY

FRANCE

Tel: (33) (0)1 69 82 61 49

Fax: (33) (0)1 69 15 78 08

E-mail: michael.dubow@u-psud.fr

EDUCATION University : SUNY Binghamton B.Sc. (Biology)

Indiana University Ph.D. (Microbiology)

Doctoral Thesis: Functions and distribution among prokaryotes of Host Factor for coliphage Qβ

RNA replication. Director: Dr. Thomas Blumenthal. Postdoc, Cold Spring Harbor Laboratory, Dr. Jim Watson (Director), Cold Spring Harbor (NY),

USA, NIH-SUNY Postdoctoral Fellow - Molecular Genetics group of A. Bukhari.

ACADEMIC CAREER

McGill University (Montreal, Canada), 1980∼2002 (McGill University, Department of

Microbiology and Immunology)

1980∼1986 (Assistant Professor).

1987∼1990 (Associate Professor - Department of Microbiology and Immunology and

Center for Human Genetics).

1991∼2002 (Full Professor - Department of Microbiology and Immunology and

Department of Human Genetics).

Université de Metz (Metz, France), 1996-1998 (ESE, UFR Sciences, Metz, France, Professor 2).

Disponibilité 1998-2002.

Université Paris-Sud (Orsay, France), 2002∼ (Université Paris-Sud, Faculty of Sciences, Orsay,

France, Professor 1).

Honors and Awards

Named to the Genetic Resources Bureau (France) 2004-2009

Elected to the National University Commission (CNU 65; France) 2007- Pres.

Wellcome Foundation for Microbiology Guest Lecturer 1999-2000

Leo Yaffe Award – Outstanding Teacher of the Faculty of Science (McGill University) 1994

Foundation for Microbiology Lecturer of the American Society for

Microbiology 1994-1996

Elected "Fellow" of the American Academy of Microbiology 1994-present

Fisher Scientific Award of the Canadian Society of Microbiologists 1988

VP – Genetics and Molecular Biology section of

the Canadian Society of Microbiologists 1988-1990

Named to the Teaching Committee (Canadian Society of Microbiologists) 1983-1986

Named to the Biotechnolgy Committee (Canadian Society of Genetics) 1982-1985

Beckman Prize for Innovative Research in Toxicology 1983

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Garner Award of the American Society for Microbiology 1975

Administrative Responsabilities (1980-2002; McGill University)

Elected Senator (Faculty of Medicine) to McGill Senate

and to the Senate Steering Committee 1989-1996

Chair, Department of Microbiology and Immunology 1994-1999

Department of Microbiology and Immunology Graduate

Committee 1985-1996; Chair, 1990-1996

Member of the Scholarship Committee (Faculty of Medicine) 1987-1990

Elected Senator (Faculty of Science) to McGill Senate 1988-1989

Administrative Responsabilities (2002 – present; Université Paris-Sud)

Vice-President (Research) of the Department of Biology

(~ 400 Professors and Research Professors) 2004 - 2009

Elected Member of the Biology Department Council 2004 - 2012

Elected Member of the Research Council of the Faculty of Science 2004- 2012

Named "Program Coordinator” for the Life Sciences 2006 - 2009

Named "Program Coordinator" for East Asian Affairs 2009-present

Creation of Start-up Companies

1. Bomec Inc. 1990-1993. 13 employees. Environmental detection. Company purchased by

Martin Marietta Inc.

2. PhageTech/Targanta Therapeutics Inc. 1997-2009. >100 Employees. IPO (Nasdaq Exchange)

in 2007. Antibiotic discovery. Purchased by the Medicines Company in 2009. 3. Biolumine SA. 2003-2009. 10 employees. Bacterial detection in the Food/Agriculture sector.

Purchased by Solabia Inc. in 2008

PEER-REVIEWED PUBLICATIONS; H-index = 31

1. Lossouarn J, Briet A, Moncaut E, Furlan S, Bouteau A, Son O, Leroy M, DuBow

MS, Lecointe F, Serror P, Petit MA. Enterococcus faecalis countermeasures defeat

a virulent picovirinae bacteriophage. Viruses 11: 48 (2019).

2. Osman JR, Regeard C, Badel C, Fernandes, G, and DuBow MS. Variation of

bacterial biodiversity from saline soils and estuary sediments present near the

Mediterranean Sea coast of Camargue (France). Antonie van Leeuwenhoek.

112: 351-365 (2019).

3. Osman JR and DuBow MS. Bacterial communities on the surface of oligotrophic

(nutrient-poor) soils. Current Topics in Biotechnology. 9: 31-44 (2018).

4. Qiu X, Xu, J, Guo J, Ammar AY, Kapetanakis N-I, Duroux-Richard I,

Unterluggauer J, Golob-Schwarzl N, Regeard C, Uzan C, Gouy S, DuBow MS,

Haybaeck J, Apparailly F, Busson P and Hildebrandt N. Advanced microRNA-

based cancer diagnostics using amplified time-gated FRET. Chemical Science. 9:

8046-8055 (2018).

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5. Osman JR, Fernandes, G, Regeard C, Jaubert, C and DuBow MS. Examination of

the bacterial biodiversity of coastal eroded surface soils from the Padza de Dapani

(Mayotte Island). Geomicrobiology Journal 35: 355-365 (2018).

6. Osman JR, Fernandes, G and DuBow MS. Bacterial diversity of the rhizosphere

and nearby surface soil of rice (Oryza sativa) growing in the Camargue (France).

Rhizosphere 3: 112-122 (2017).

7. Osman JR, de Zelicourt A, Bisseling T, Geurts R, Hirt H and DuBow MS. Bacterial

rhizosphere biodiversity from several pioneer desert sand plants near Jizan, Saudi

Arabia. The Open Conf. Proc. J. 7: 70-79 (2016).

8. An S, Sin HH and DuBow MS. Modification of atmospheric sand-associated

bacterial communities during Asian sandstorms in China and South Korea.

Heredity: 114: 460-467 (2015).

9. Kovalova Z, Leroy M, Jacobs C, Kirkpatrick MJ, Machala Z, Lopes F, Laux CO,

DuBow MS and Odic E. Atmospheric pressure argon surface discharges

propagated in long tubes: physical characterization and application to bio-

decontamination. J. Physics D: Applied Physics 48: 464003 (2015).

10. Winter C, Garcia JA, Weinbauer MG, DuBow MS Herndl GJ. Comparison of

deep-water viromes from the Atlantic Ocean and the Mediterranean Sea. PloS One.

9: e100600. (2014).

11. Jakubek D, Guillaume C, Binet, M, Leblon G, DuBow MS and Le Brun M.

Susceptibility of Legionella strains to the chlorinated biocide, Monochloramine.

Microbes and Environments 28: 336-345 (2013).

12. An S, Couteau C, Luo F, Neveu J and DuBow MS. Bacterial diversity of surface

sand samples from the Gobi and Taklamaken deserts. Microbial Ecology. 66: 850-

860 (2013).

13. Jakubek D, Le Brun M, Leblon G, DuBow MS and Binet M. The impact of

monochloramine on the diversity and dynamics of Legionella pneumophila

subpopulations in a nuclear power plant cooling circuit. FEMS Microbiology

Ecology. 85: 302-312 (2013).

14. Prestel E, Regeard C, Salamitou S, Neveu, J and DuBow MS. The bacteria and

bacteriophages from a Mesquite Flats site of the Death Valley desert. Antonie van

Leeuwenhoek. 103: 1329-1341 (2013).

15. Jakubek D, Le Brun M, Leblon G, DuBow MS and Binet M. Validation of IRS

PCR, a molecular typing method, for the study of the diversity and population

dynamics of Legionella in industrial cooling circuits. Letters in Applied

Microbiology. 56: 135-141 (2013).

16. Sauge-Merle S, Lecomte-Pradines C, Carrier P, Cuine S and DuBow MS. Heavy

metal accumulation by recombinant mammalian metallothionein within Escherichia

coli protects against elevated metal exposure. Chemosphere. 88: 918–924 (2012).

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17. Ray JL, Töpper B, An S, Silyakova A, Spindelböck J, Thyrhaug R, DuBow MS,

Thingstad TF and Sandaa R-A. Effect of increased pCO2 on bacterial assemblage

shifts in response to glucose addition in Fram Strait seawater mesocosms. FEMS

Microbiology Ecology. 82:713-723 (2012).

18. Prestel E, Regeard C, Andrews J, Oger P and DuBow MS. A novel bacteriophage

morphotype with a ribbon-like structure at the tail extremity. Research Journal of

Microbiology. 7: 75-81 (2012).

19. Cirou A, Mondy S, An S, Charrier A, Sarrazin A, Thoison O, DuBow MS and

Faure D. Efficient biostimulation of the native and introduced quorum-quenching

Rhodococcus erythropolis is revealed by a combination of analytical chemistry,

microbiology and pyrosequencing. Applied and Environmental Microbiology. 78:

481-492 (2012).

20. Poitelon J-B, Joyeux M, Welté B, Duguet J-P, and DuBow MS. The drinking water

distribution network: a complex ecosystem related to public health issues. Journal

of Water Science. 24: 383-418 (2011).

21. De Luca G, Barakat M, Ortet P, Fochesato S, Jourlin-Castelli C, Ansaldi M, Py B,

Fichant G, Coutinho PM, Voulhoux R, Bastien O, Maréchal E, Henrissat B,

Quentin Y, Noirot PH, Filloux A, Méjean V, DuBow MS, Barras F, Barbe V,

Weissenbach J, Mihalcescu I, Verméglio A, Achouak W and Heulin T. The cyst-

dividing bacterium Ramlibacter tataouinensis TTB310 genome reveals a well-

stocked toolbox for adaptation to a desert environment. PloS One. 6: e23784.

(2011).

22. Neveu J, Regeard C and DuBow MS. Isolation and characterization of two serine

proteases from metagenomic libraries of the Gobi and Death Valley deserts.

Applied Microbiology and Biotechnology. 91: 635-644 (2011).

23. Marchal M, Briandet R, Halter D, Koechler S, DuBow MS, Lett M-C and Bertin

PM. Subinhibitory arsenite concentrations lead to population dispersal in

Thiomonas sp. PloS One. 6: e23181 (2011).

24. Deschavanne P, DuBow MS and Regeard C. The use of genomic signature distance

between bacteriophages and their hosts displays evolutionary relationships and

phage growth cycle determination. Virology Journal 7:163 (2010).

25. Poitelon J-B, Joyeux M, Welté B, Duguet J-P, Prestel E and DuBow MS.

Variations of bacterial 16S rDNA phylotypes prior to and after chlorination for

drinking water production from two surface water treatment plants. Journal of

Industrial Microbiology and Biotechnology. 37: 117-128 (2010).

26. Salamitou S, Kirkpatrick MJ, Ly HM, Leblon G, Odic E and DuBow MS.

Augmented Survival of Bacteria Within Biofilms to Exposure to an Atmospheric

Pressure Non-Thermal Plasma Source. Biotechnology. 8: 228-234 (2009).

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27. Dehbi M, Moeck G, Arhin FF, Bauda P, Bergeron D, Kwan T, Liu J, McCarty J,

DuBow MS and Pelletier J. Inhibition of Transcription in Staphylococcus aureus

by a Primary Sigma Factor-Binding Polypeptide from Phage G1. Journal of

Bacteriology. 191: 3763–3771 (2009).

28. Poitelon J-B, Joyeux M, Welté B, Duguet J-P, Peplies J and DuBow MS.

Identification and phylogeny of eukaryotic 18S rDNA phylotypes detected in

chlorinated finished drinking water samples from three Parisian surface water

treatment plants. Letters in Applied Microbiology. 49: 589 – 595 (2009).

29. Poitelon J-B, Joyeux M, Welté B, Duguet J-P, Prestel E, Lespinet O and DuBow

MS. Assessment of phylogenetic diversity of bacterial microflora in drinking water

using serial analysis of ribosomal sequence tags. Water Research. 43: 4197-4206

(2009).

30. Prestel E, Salamitou, S and DuBow MS. An examination of the bacteriophages and

bacteria of the Namib Desert. Journal of Microbiology. 46: 364-372 (2008).

31. Leroy M, Prigent M, Dutertre M, Confalonieri F and DuBow MS. Bacteriophage

morphotype and genome diversity in Seine River sediment. Freshwater Biology.

53:1176-1185 (2008).

32. Gueuné H, Durand MJ, Thouand G and DuBow MS. The ygaVP genes of

Escherichia coli form a tributyltin-inducible operon. Applied and Environmental

Microbiology. 74:1954-1958 (2008).

33. Belley A, Callejo M, Arhin F, Dehbi M, Fadhil I, Liu J, McKay G, Srikumar R,

Bauda P, Ha N, DuBow MS, Gros P, Pelletier J, and Moeck G. Competition of

bacteriophage polypeptides with native replicase proteins for binding to the DNA

sliding clamp reveals a novel mechanism for DNA replication arrest in

Staphylococcus aureus. Molecular Microbiology. 62: 1132-1143 (2006).

34. Kwan T, Liu J, DuBow MS, Gros P and Pelletier J. Comparative genomic analysis

of 18 Pseudomonas aeruginosa bacteriophages. Journal of Bacteriology. 188: 1184-

1187 (2006).

35. Durand MJ, DuBow MS, Horry H, Picart P, Daniel P, S Lebeau and Thouand G.

Detection of tributyl and dibutyl tin in the environment with a bioluminescent

bacteria: from the bioassay to the biosensor. Trends in Agriculture and Soil

Pollution Research. 1: 1-42 (2006).

36. Prigent M, Leroy M, Confalonieri F, Dutertre M and DuBow MS. A diversity of

bacteriophage forms and genomes can be isolated from the surface sands of the

Sahara Desert. Extremophiles. 9: 289-296 (2005).

37. Kwan T, Liu J, DuBow MS, Gros P and Pelletier J. The complete annotated

genome sequences of 27 Staphylococcus aureus bacteriophages. Proc. Natl. Acad.

Sci. USA. 102 : 5174-5179 (2005).

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38. Siboo IR, Sieder F, Kumar K, Howe MM and DuBow MS. Characterization of

P(lys)-proximal morphogenetic genes of transposable bacteriophage Mu. Arch.

Virology. 149:241-259 (2004).

39. Liu J, Dehbi M, Moeck G, Arhin F, Bauda P, Bergeron D, Callejo M, Ferretti V, Ha

N, Kwan T, McCarty J, Srikumar R, Williams D, Wu JJ, Gros P, Pelletier J, and

DuBow MS. Antimicrobial drug discovery through bacteriophage genomics.

Nature Biotechnology. 22:185-191 (2004).

40. Thouand, G, Daniel, P, Horry, H, Picart, P, Durand, M-J, Knox, OGG, DuBow, MS

and Rousseau, M. Comparison of the spectral emission of lux recombinant and

bioluminescent marine bacteria. Luminescence. 18:145-155 (2003).

41. Durand, M-J, Thouand, G, Dancheva, T, Vachon, P and DuBow, MS. Specific

detection of organotin compounds with a recombinant luminescent bacteria.

Chemosphere. 52:103-111 (2003).

42. Thouand, G, Horry, H, Durand, M-J, Picart, P, Bendriaa, L. Daniel, P and DuBow,

MS. Development of a biosensor for on line detection of organotin compounds

with a recombinant bioluminescent Escherichia coli strain. Applied Microbiology

and Biotechnology. 62:185-191 (2003).

43. Alexander, DC, Costanzo, M, Guzzo, J, Cai, J, Charoensri, N, Diorio, C and DuBow,

MS. Blazing towards the next millenium: luciferase fusions to identify genes

responsive to environmental stress. Water, Air and Soil Pollution. 123:81-94. (2001).

44. Thouand G, Durand MJ, Picart P, Daniel P, Massé J and DuBow, MS. Detection of

bacteria in the food with bioluminescent sensors. Rec. Res. Develop. Microbiol.

5:79-93 (2001).

45. Guzzo, J. and DuBow, MS A Novel Selenite/Tellurite-Inducible Gene in Escherichia

coli. Applied and Environmental Microbiology. 66:4972-4978 (2000).

46. Salmon, K.A., Freedman, O., Ritchings, B.W. and DuBow, M.S. Characterization of

the Lysogenic Repressor of the Pseudomonas aeruginosa Transposable

Bacteriophage D3112. Virology. 272:85-97 (2000).

47. Kukolj, G. and DuBow, M.S. The Bacteriophage D108 Ner Repressor Binds a

Conformationally Distinct Operator. Molecular and General Genetics. 263:592-600

(2000).

48. Genevaux P., Bauda P., DuBow M.S. and Oudega B. Identification of Tn10

insertions in the rfaG, rfaP, and galU genes involved in lipopolysaccharide core

biosynthesis that affect Escherichia coli adhesion. Archives of Microbiology. 172:1-8

(1999).

49. Genevaux P., Bauda P., DuBow M.S. and Oudega B. Identification of Tn10

insertions in the dsbA gene affecting Escherichia coli biofilm formation. FEMS

Microbiology Letters. 173:403-409 (1999).

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50. Cai, J., Salmon K. and DuBow, M.S. A Chromosomal ars Operon Homologue of

Pseudomonas aeruginosa Confers Increased Resistance to Arsenic and Antimony in

Escherichia coli. Microbiology. 144:2705-2713 (1998).

51. DuBow, M.S. The Detection and Characterization of Genetically-Programmed

Responses to Environmental Stress. Annals of the New York Academy of Sciences.

851: 286-291 (1998).

52. Billard, P. and DuBow, M.S. Bioluminescence-based Assays for Detection and

Characterization of Bacteria and Chemicals in Clinical Laboratories. Clinical

Biochemistry. 31:1-14 (1998).

53. Costanzo, M.A., Guzzo, J., and DuBow, M.S. Luciferase-based Measurements of

Water Contamination in the Environment. Methods in Molecular Biology. 102: 201-

217 (1998).

54. Alexander, D.C. and DuBow, M.S. Probing for Promoters with Luciferase

Transposons. Methods in Molecular Biology. 102: 105-122 (1998).

55. Ackermann, H.-W., DuBow, M.S., Gershman, M., Karska-Wysocki, B., Kasatiya,

S.S., Loessner, M.J., Mamet-Bratley, M.D. and Regué, M. Taxonomic Changes in

Tailed Phages of Enterobacteria. Archives of Virology. 142:1381-1390 (1997).

56. Cai, J. and DuBow, M.S. Use of a Luminescent Bacterial Biosensor for

Biomonitoring and Characterization of Arsenic Toxicity of Chromated Copper

Arsenate (CCA). Biodegradation. 8: 97-103 (1997).

57. Cai, J. and DuBow, M.S. Expression of the Escherichia coli Chromosomal ars

Operon. Canadian Journal of Microbiology. 42: 662-671 (1996).

58. Ulycznyj, P.I., Salmon, K.A., Douillard, H. and DuBow, M.S. Characterization of the

Pseudomonas aeruginosa Transposable Bacteriophage D3112 A and B genes.

Biochimica and Biophysica Acta. 1264: 249-253 (1995).

59. Cameron, R.K., Ulycznyj, P. and DuBow, M.S. Mu Transposase-Stimulated

Illegitimate Recombination of Tn3kan and IS101 Containing Plasmids. Research in

Microbiology. 146:601-616 (1995).

60. Diorio, C., Cai, J., Marmor, J., Shinder, R. and DuBow, M.S. An Escherichia coli

Chromosomal ars Operon Homologue Is Functional in Arsenic Detoxification and

Conserved in Gram-negative Bacteria. Journal of Bacteriology. 177: 2050-2056

(1995).

61. Saint-Dic, D. and DuBow, M.S. Effect of Cis-located Human Satellite DNA on

Electroporation Efficiency. Methods in Molecular Biology. 48: 199-210 (1995).

62. Guzzo, A., Karatzios, C., Diorio, C. and DuBow, M.S. Metallothionein - II and

Ferritin H mRNA Levels are Increased in Arsenite Exposed HeLa Cells. Biochemical

and Biophysical Research Communications. 205: 590-595 (1994).

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63. Benevides, J.M., Kukolj, G., Autexier, C., Aubrey, K.L., DuBow, M.S. and Thomas

Jr., G. J. Secondary Structure and Interaction of Phage D108 Ner Repressor with a 61

Base-Pair Operator: Evidence for Altered Protein and DNA Structures in the

Complex. Biochemistry. 33: 10701-10710 (1994).

64. DuBow, M. S. and Lalumière, M. The Proximity of Mini-Mu Termini Can Affect

The Products of DNA Transposition. Canadian Journal of Microbiology. 40: 567-575

(1994).

65. Guzzo, A. and DuBow, M.S. Identification and Characterization of Genetically-

Programmed Responses to Toxic Metal Exposure in Escherichia coli. FEMS

Microbiology Reviews. 14: 369-374 (1994).

66. Harel, J. and DuBow, M.S. Neighboring Plasmid Sequences Can Affect Mini-Mu

DNA Transposition in the Absence of Expression of the Bacteriophage Mu Semi-

Essential Early Region. Archives of Microbiology. 161: 418-424 (1994).

67. Blaise, C., Forgani, R., Legault, R., Guzzo, J. and DuBow, M.S. A Bacterial Toxicity

Assay Performed with Microplates, Microluminometry, and Microtox Reagent.

BioTechniques. 16: 932-937 (1994).

68. Ulycznyj, P.I., Forghani, F. and DuBow, M.S. Characterization of Functionally

Important Sites in the Bacteriophage Mu Transposase Protein. Molecular and General

Genetics. 242: 272-279 (1994).

69. Guzzo, A. and DuBow, M.S. A luxA,B Transcriptional Fusion to the celF Gene of

Escherichia coli Displays Increased Luminescence in the Presence of Nickel.

Molecular and General Genetics. 242: 455-460 (1994).

70. Invited Review: DuBow, M.S. Antituberculosis Drug Screening. The Lancet. 342:

448-449 (1993).

71. Brisebois, J., and DuBow, M.S. Selection for Spontaneous Null Mutations in a

Chromosomally-Integrated HSV-1 Thymidine Kinase Gene Yields Deletions and a

Mutation Caused by Intragenic Illegitimate Recombination. Mutation Research.

287:191-205 (1993).

72. Sol, K., and DuBow, M.S. Sequence Analysis of Cloned Human Satellite DNAs

Reveal Non-random Variations. Genome. 36:334-342 (1993).

73. Kukolj, G., and DuBow, M.S. Integration Host Factor Activates the Ner-Repressed

Early Promoter of Transposable Mu-Like Phage D108. Journal of Biological

Chemistry. 267 : 17827-17835 (1992).

74. Fouquet, C., and DuBow, M.S. Effect of cis-Located Human Satellite DNA on the

Electroporation Efficiency of neo and HSV-1 TK Containing Plasmids. Mutation

Research. 284 : 321-328 (1992).

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75. Guzzo, J., Guzzo, A., and DuBow, M.S. Characterization of the Effects of Aluminum

on Luciferase Biosensors for the Detection of Ecotoxicity. Toxicology Letters. 64/65 :

687-693 (1992).

76. Autexier, C., and DuBow, M.S. The Escherichia coli Mu/D108 Phage ner Homologue

(nlp) Gene is Transcribed and Evolutionarily Conserved Among the

Enterobacteriaceae. Gene. 114 :13-18 (1992).

77. Sol, K., and DuBow, M.S. Structure and Organization of a Human EcoR1 Satellite II

DNA Family. Life Science Advances Molecular Biology. 11 :159-168 (1992).

78. Ackermann, H.-W., DuBow, M.S., Jarvis, A.W., Jones L.A., Krylov, V.N., Maniloff,

J., Rocourt, J., Safferman, R.S., Schneider, J., Seldin, L., Sozzi, T., Stewart, P.R.,

Werkin, M., and Wunsche, L. The Species Concept and its Application to Tailed

Phages. Archives of Virology. 124 :69-82 (1992).

79. Fouquet, C., and DuBow, M.S. Detection of Human Satellite II DNA-Binding

Proteins in HeLa Cellular and Nuclear Extracts. Biochem. Intl. 27 :457-464 (1992).

80. Kukolj, G., and DuBow, M.S. Characterization of the Lysogenic Repressor (c) from

Transposable Mu-Like Bacteriophage D108. Nucleic Acids Research. 19 :5949-5956

(1991).

81. Guzzo, A., and DuBow, M.S. Construction of Stable Single-Copy Luciferase Gene

Fusions in Escherichia coli. Archives of Microbiology. 156 :444-448 (1991).

82. Autexier, C., Wragg-Légaré, S. and DuBow, M.S. Characterization of the

Pseudomonas aeruginosa Transposable Phage D3112 Left End Regulatory Region.

Biochimica and Biophysica Acta. 1088 :147-150 (1991).

83. Guzzo, A., Diorio, C. and DuBow, M.S. Transcription of the Escherichia coli fliC

Gene is Regulated by Metal Ions. Applied and Environmental Microbiology. 57:

2255-2259 (1991).

84. Burns, C.M., Chan, H.L.B. and DuBow, M.S. In Vitro Maturation and Encapsidation

of Mu-Like Transposable Phage D108. Proceedings of the National Academy of

Sciences (USA). 87 :6092-6096 (1990).

85. Harel, J., Duplessis, L., Kahn, J.S. and DuBow, M.S. The cis-Acting DNA Sequences

Required For Bacteriophage Mu Transposition And Packaging in vivo. Archives of

Microbiology. 154 :67-72 (1990).

86. Kukolj, G., Tolias, P.P., Autexier, C. and DuBow, M.S. DNA-Directed

Oligomerization of the Monomeric Ner Repressor From Bacteriophage D108. EMBO

Journal. 8 :3141-3149 (1989).

87. Kukolj, G., Tolias, P.P. and DuBow, M.S. Purification and Characterization of the

Ner Repressor of Bacteriophage Mu. FEBS Letters. 244: 369-375 (1989).

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88. Tolias, P.P. and DuBow, M.S. A Sequence-Specific DNA Binding Domain Resides

in the 13 KDa Amino Terminus of the Bacteriophage Mu Transposase. Journal of

Molecular Recognition. 1 :172-178 (1989).

89. Levin, D.B. and DuBow, M.S. Regulation of Repressor and Early Gene Expression in

Mu-Like Transposable Bacteriophage D108. Molecular and General Genetics. 217:

392-400 (1989).

90. Kupelian, A., Bilimoria, M.H. and DuBow, M.S. Microsomal-Activated Cigarette

Smoke Condensate Reduces Mu Transposase Gene Expression in recA+ Escherichia

coli. Toxicity Assessment. 4: 71-84 (1989).

91. Cameron, R.K., Jarjour, A.M., Tolias, P.P. and DuBow, M.S. The Bacteriophage Mu

Transposase Protein Can Form High-affinity, Protein-DNA Complexes With the Ends

of Transposable Elements of the Tn3 Family. FEBS Letters. 229: 283-288 (1988).

92. Boismenu, R., DuBow, M.S. and Murgita, R.A. Expression of Domains of Mouse

Alpha-Fetoprotein in Escherichia coli. Life Sciences. 43: 673-681 (1988).

93. Szatmari, G.B., Lapointe, M. and DuBow, M.S. The Right End of Transposable

Bacteriophage D108 Contains a 520 Base Pair Protein-Encoding Sequence Not

Present in Bacteriophage Mu. Nucleic Acids Research. 15: 6691-6704 (1987).

94. Tolias, P.P. and DuBow, M.S. The Bacteriophage D108 Transposase Protein Contains

a Two-Component, Sequence-Specific, DNA-Binding Domain. Virology. 157: 117-

126 (1987).

95. Goring, D.R., Gupta, K. and DuBow, M.S. Analysis of Spontaneous Mutations in a

Chromosomally Located HSV-1 Thymidine Kinase (tk) Gene in a Human Cell Line.

Somatic Cell and Molecular Genetics. 13: 47-56 (1987).

96. Levin, D.B. and DuBow, M.S. Cloning and Localization of the Repressor Gene (c) of

the Mu-Like Transposable Phage D108. FEBS Letters. 222: 199-203 (1987).

97. Sol, K., Lapointe, M., MacLeod, M., Nadeau, C. and DuBow, M.S. A Cloned

Fragment of HeLa DNA Containing Consensus Sequences of Satellite II and III DNA

Hybridises With the Drosophila P-Element and with the 1.8 kb Family of Human

KpnI Fragments. Biochimica and Biophysica Acta 868: 128-135 (1986).

98. Szatmari, G.B., Kahn, J.S. and DuBow, M.S. The Characterization of Insertions of the

Transposable Bacteriophages Mu and D108 in the Plasmid pSC101. Gene. 41: 315-

319 (1986).

99. Kupelian, A. and DuBow, M.S. The Effect of Gamma Irradiation on Mu DNA

Transposition and Gene Expression. Mutation Research. 160: 1-10 (1986).

100. Tolias, P.P. and DuBow, M.S. The Overproduction and Characterization of the

Bacteriophage Mu Regulatory DNA-Binding Protein Ner. Virology. 148: 298-311

(1986).

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101. DuBow, M.S. and Shinder, G., Prophage Mu Induction as a Tool To Analyze Mobile

Genetic Element Responses to External Agents. Toxicity Assessment. 1: 41-55

(1986).

102. Tolias, P.P. and DuBow, M.S. The Cloning and Characterization of the

Bacteriophage D108 Regulatory DNA-Binding Protein Ner. EMBO Journal. 4: 3031-

3037 (1985).

103. Goring, D.R. and DuBow, M.S. A Cytotoxic Effect Associated with 9-(1,3-

Dihydroxy-2-Propoxymethyl) Guanine is Observed During the Selection for Drug-

Resistant Human Cells Containing a Single Herpes Virus Thymidine Kinase Gene.

Biochemical and Biophysical Research Communications. 133: 195-201 (1985).

104. DuBow, M.S. and Bukhari, A.I. Regulation of Bacteriophage Mu and Mini-Mu DNA

Replication in vivo. Biochem. Intl. 10: 945-953 (1985).

105. Coulton, J.W., Mason, P. and DuBow, M.S., Molecular Cloning of the Ferrichrome-

Iron Receptor of Escherichia coli K12. Journal of Bacteriology. 156: 1315-1321

(1983).

106. Chaconas, G., DeBruijn, F., Casadaban, M.J., Lupski, J.R., Kwoh, T.J., Harshey,

R.M., DuBow, M.S. and Bukhari, A.I., In vitro and in vivo Manipulations of

Bacteriophage Mu DNA: Cloning of Mu Ends and Construction of Mini-Mu's

Carrying Selectable Markers. Gene. 13: 37-46 (1981).

107. DuBow, M.S. and Bukhari, A.I. Effects of Prophage Mu Induction on Expression of

Adjacent Host Genes. Mol. Biol. Rep. 6: 229-234 (1980).

108. Ljungquist, E., Khatoon, H., DuBow, M.S., Ambrosio, L., DeBruijn, F. and Bukhari,

A.I., Integration of Bacteriophage Mu DNA. Cold Spring Harbor Symp. Quant. Biol.

43: 1151-1158 (1978).

109. DuBow, M.S. and Ryan, T., Host Factor for Coliphage Qß RNA Replication as an Aid

in Elucidating Phylogenetic Relationships: The Genus Pseudomonas. Journal of

General Microbiology. 102: 263-268 (1977).

110. DuBow, M.S., Ryan, T., Young, R.A. and Blumenthal, T., Host Factor for Coliphage

Qß RNA Replication: Presence in Procaryotes and Association with the 30S Subunit

in Escherichia coli. Molecular and General Genetics. 153: 39-43 (1977).

111. DuBow, M.S. and Blumenthal, T. Host Factor for Coliphage Qß RNA Replication is

Present in Pseudomonas putida. Molecular and General Genetics. 141: 113-119

(1975).

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Selected recent conference presentations

1. S. An, C. Couteau, J. Neveu et M.S. DuBow. Bacterial diversity of surface sand samples from Asian deserts and their potential for long-distance transport by Asian sandstorms. 4th Congress of European Microbiologists (FEMS 2011). June, 2011, Génève, Suisse

2. S. An, T. Nguyen, M. Weinbauer et M.S. DuBow. Genomic approaches to examine the

bacterial diversity of Asian desert samples and their potential for long-distance transport by Asian sandstorms. 13th International Symposium on Microbial Ecology (ISME-13). August, 2010, Seattle, WA, USA.

3. J. B. Poitelon, M. Joyeux, B. Welté, J. P. Duguet, E. Prestel, O. Lespinet and M. S.

DuBow. An assessment of the microbial diversity present in water from three Parisian surface water treatment plants. III International Conference on Environmental, Industrial and Applied Microbiology: BioMicroWorld 2009. Lisbon, Portugal, December, 2009.

4. J-B. Poitelon, E. Prestel, E. Delahaye, B. Welte, J-P Duguet, O. Lespinet, M.S. DuBow et

M. Joyeux. Profiling of Bacterial Diversity Produced by Parisian Drinking Water Treatment Plants Using SARST-V6. Society for Applied Microbiology Summer Conference 2008. July, 2008. Belfast, UK.

5. E. Prestel, F. Luo, J. Neveu, J-B. Poitelon, C. Regeard, S. Salamitou, M. Terrier et M.S.

DuBow. Le Rôle des Phages et des Bactéries dans les Biofilms d’Écosystèmes Arides et Aquatiques. Third Congress of the National Biofilm Network. June 2008, Dourdan, France.

6. E. Prestel, F. Luo, J. Neveu, J-B. Poitelon, C. Regeard, S. Salamitou, M. Terrier et M.S.

DuBow. Studies on the Phage and Bacterial Populations of Aquatic and Desert Ecosystems. Genomics and Ecology of Aquatic Viruses. February, 2008. Banyuls-sur-Mer, France.

7. Invited Speaker - Prestel E, Regeard C, Salamitou S et DuBow MS. The diversity and

ecological role of bacteriophages in arid regions. 11th International Symposium on Microbial Ecology (ISME-11). August, 2006, Vienna, Austria.

8. Dehbi M, Arhin F, Bauda P, Bergeron D, Delorme D, Dietrich E, Far A, Kwan T, Liu J,

McCarty J, Moeck G, Srikumar R, Williams D, DuBow M, Pelletier J et Gros P. The Primary Sigma Factor of Staphylococcus aureus: From Target Identification to Isolate Inhibitors of the RNA Polymerase Holoenzyme. 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), December, 2005, Washington, DC (USA).

9. Invited Keynote Speaker – Arab R, Giloteaux L, Prestel, E, Regeard C, Salamitou S,

Therrier M et DuBow, MS. The return of the phages : Structural and functional metagenomic approaches to determine their diversity and role in microbial ecology and genomics. 8th International Symposium on Bacterial Genetics and Ecology (BAGECO). June, 2005, Lyon, France.

10. Odic, E, Limam, S, Kirkpatrick, MJ, Dodet, B, Salamitou, S and DuBow MS.

Investigations of Bacterial Inactivation and DNA Fragmentation Induced by Flowing Humid Argon Post-discharge. In: Plasma for Bio-Decontamination, Medicine and Food Security (Z. Machala, K. Hensel and Y. Akishev, eds.), Springer; Dordrecht, the Netherlands, pp. 93-106 (2012).

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Book chapters/Conference proceedings

1. Khatoon, H., Chaconas, G., DuBow, M.S. and Bukhari, A.I. The Mu Paradox: Excision

Versus Replication. In: The Eighth Annual ICN-UCLA Symposia-Extrachromosomal DNA. Academic Press, N.Y., 1979. pp. 143-154.

2. Chaconas, G., Harshey, R.M., DuBow, M.S., Sarvetnick, N. and Bukhari, A.I.,

Transposable Genetic Elements: The Mu Paradigm. In: Miami Winter Symposium 1980-Mobilization and Reassembly of Genetic Information. Academic Press, N.Y., 1980. pp. 81-91.

3. DuBow, M.S. and Bukhari, A.I., The Proteins of Bacteriophage Mu: Composition of

the Virion and Biosynthesis in vivo During Lytic Growth. In: Bacteriophage Assembly. DuBow, M.S. Editor. Alan R. Liss Inc., N.Y. 1981. pp. 47-67.

4. Shinder, G., Tourjman, S. and DuBow, M.S., Bacteriophage Mu DNA Transposition to

Identify New Classes of Genotoxic Agents. In: Toxicity Screening Procedures Using Bacterial Systems. Liu, D. and Dutka, B.J. (eds.). Marcel Dekker Inc., N.Y. pp. 295-308 (1984).

5. DuBow, M.S. Transposable Mu-Like Bacteriophages. In: Phage Mu, Symonds, N.,

Toussaint, A., van de Putte, P. and Howe, M. (eds.), Cold Spring Harbor Laboratory Press, pp. 299-314 (1988).

6. DuBow, M.S. and Guzzo, A. Luminescent Bacterial Biosensors to Detect Toxic Agents

and Elucidate Molecular Mechanisms of Toxicity. Proceedings of the XV International Symposium on Wastewater Treatment; pp. 245-253 (1992).

7. Guzzo, A. and DuBow, M.S. Selenium-Induced Gene Expression to Create

Luminescent Biosensors and to Elucidate Genetically-Programmed Responses to Selenium Exposure. Proceedings of the IX International Conference on Heavy Metals in the Environment. 1: 407-410 (1993).

8. DuBow, M.S. Use of Phages in Bacterial Identification. In: Encyclopedia of Virology.

Webster, R.G. and Granoff, A. (eds.), Academic Press; London, UK; pp. 78-81 (1994).

9. DuBow, M.S. Mu and Related Bacteriophages. In: Encyclopedia of Virology. Webster, R.G. and Granoff, A. (eds.), Academic Press; London, UK; pp. 868-876 (1994).

10. Briscoe, S.F., Diorio, C., and DuBow, M.S. Luminescent biosensors for the detection

of tributyltin and dimethyl sulfoxide and the elucidation of their mechanisms of toxicity, in Environmental Biotechnology: Prinicples and Practice, Moo-Young, M., Anderson, W.A., and Chakrabarty, A.M., Eds., Kluwer Academic Publishers, pp. 645-655, 1996

11. Diorio, C. and DuBow, M.S. Molecular Approaches to Aluminium, Arsenic and

Selenium Toxicity in Procaryotes and Eucaryotes. In: Metal Ions in Biology and Medicine. Collery, P., Corbella, J., Domingo, J.L., Etienne, J-C., and Globet, J.M. (eds.), John Libby Eurotext, Paris, pp. 67-69 (1996).

12. DuBow, M.S. Luminescence-Based Assays to Detect and Characterize Chemical and

Biological Water Contaminants. In: Biotechnology For Water Use and Purification.

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Hirakawa, T. and Wald, S. (eds.), Organization For Economic Cooperation and Development (OECD), Paris, France, pp. 149-156 (1997).

13. Briscoe, S.F., Cai, J. and DuBow, M.S. Luminescent Bacterial Biosensors for the Rapid

Detection of Toxicants. In: P.G. Wells K. Lee and C. Blaise, eds., Microscale Aquatic Toxicology - Advances, Techniques and Practice, CRC Lewis Publishers, Boca Raton, Florida, pp. 161-170 (1998).

14. DuBow, M.S. Bacterial Identification: Use of Phages. In: Encyclopedia of Virology.

Webster, R.G. and Granoff A. (eds.), Academic Press; London, UK; pp. 137-139 (1999).

15. DuBow, M.S., Mu-like Phages (Myoviridae). In: Encyclopedia of Virology. Webster, R.G. and Granoff, (eds.), Academic Press; London, UK; pp. 981-988 (1999).

16. Guzzo, J., Diorio, C., Alexander, D.C. and DuBow, M. S. Towards Understanding

Metal Stress in Environmemtal Microbial Flora. In Microbial Biosystems: New Frontiers ( Bell, C. R., Brylinski, M. and Johnson-Green, P.; Eds), Atlantic Canada Society for Microbial Ecology. pp. 243-251 (2001).

17. DuBow, MS. Mu-like viruses. In : The Springer Index of Viruses (Tidona, CA, Darai,

G eds), © Springer-Verlag Heidelberg. pp. 548-552 (2001).

New Courses Developed (past 10 years)

1. Physics of Biological Systems (Undergraduate) 2. Fundamental Virology (Undergraduate and Graduate levels) 3. Microbial Evolution and Biodiversity (Undergraduate and Graduate levels) 4. Effective Communication in 21st Century English (All levels, including Adult

Education)

5. Life Sciences for Engineers (All levels, including Adult Education)

6. Biology for Non-Scientists (All levels, including Adult Education)