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Curriculum VitÆ PERSONAL DATA Name : Jan Bakker MD PhD FCCP CURRENT WORK 04-2005 – current : Professor of Medicine Erasmus University Rotterdam 05-2014 – current : Professor of Medicine Pontificia Universidad Cathólica

Santiago de Chile (part time) 09-2014 – current : Teaching professor Technical University Delft (bachelor and

master Medical Technology – part time) 03-2016 – current : Adjunct-professor Division of Pulmonary, Allergy, and

Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York (part time)

10-2016 – current : Associate-professor Department of Pulmonary and Critical Care New York University Langone Medical Center – Bellevue Hospital, New York (part time)

01-2018 – current : Editor-in-chief Journal of Critical Care (Elsevier)

02-2018 – current : Consultant Vatican-Lancet-Mario Negri Commission on the value of Life

EDUCATION AND MEDICAL TRAINING 08-1979 : Bachelor Psychology 1979 Free University of Amsterdam Medicine 08-1985 : Master in Medicine University of Amsterdam 05-1987 : MD University of Amsterdam Internal Medicine & Intensive Care 08-1987 to 12-1989 : Dept of Medicine Hospital Hilversum, Dr. F. van Kersen 12-1989 to 01-1991 : Dept of Intensive Care Hopital Erasme Brussel, Prof. Dr. J-L

Vincent 01-1991 to 09-1991 : Dept of Medicine Hospital Hilversum, Dr. F. van Kersen 09-1991 to 01-1994 : Dept of Medicine University Hospital Utrecht, Prof. Dr. D.W.

Erkelens 01-1994 to 04-1995 : Dept of Medicine and Anesthesiology ZcA Lukas Hospital, Dr.

D. van Toorn 04-1995 : Registration Internal Medicine 12-1995 : Registration Intensive Care 12/2017 : Full Medical Licensure State of New York.

License number:291945-1 Post Doc Training

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05-2003 : Media training for Radio and Television (BBC, UK) 07-2008 : INSEAD Fontaine Bleu: European Health Leadership Program

(F) 09-2013 : Quality assessment for Members Supervisory Boards (NL) PHD THESIS March 11 1994 University Utrecht

: Tissue oxygenation in septic shock: A persisting challenge

Promotor : Prof. J-L. Vincent MD, PhD, Hopital Erasme Universite Libre de Bruxelles, Brussels, Belgium Prof. D.W. Erkelens MD, PhD. University Hospital Utrecht

Committee : Prof. G. Gutierrez MD, University of Texas, Houston, USA Prof. M.R. Pinsky MD, University of Pittsburgh, Pittsburgh, USA Prof.L.G. Thijs MD PhD, Free University Amsterdam Prof.R.J.A. Goris MD PhD, University Nijmegen Prof.Ch.van der Werken MD PhD, University Utrecht Prof. H.T.A. Knape MD PhD, University Utrecht

WORK Professional commercial 01-1993 to 05-2001 : Medical director Ambulance services GGD Gooi en

Vechtstreek, broeder de Vries Hilversum and broeder de Vries Veenendaal

10-2011 to 10-2012 : Medical Director (employed from Erasmus MC) Applied Physiology, Sydney (Australia)

Professional medical 04-1995 to 05-2001 : Intensivist Gelre ziekenhuizen Lukas, Intensivist – director of

research 05-2001 to 09-2001 : Yamaguchi University, Department of Emergency Medicine

and Intensive Care, Yamaguchi Japan 01-1998 to 05-2004 : Consultant University Hospital Utrecht

(Julius Center for Patient-Oriented Research) 09-2001 to 03-2004 : Medical director of Intensive Care. Isala klinieken Zwolle 01-2002 to 03-2004 : Medical Manager Departments of Intensive Care – Operating

Rooms and Central Sterilization Isala klinieken 01-2008 to 06-2011 : Chair Division of Intensive Care, Anesthesiology and

Operating Rooms ErasmusMC University Medical Center Rotterdam

05-2008 to 06-2011 : Chair fellow program department of Intensive Care Adults Erasmus MC

06-2011 to 02-2015 : Vice-chair fellow program department of Intensive Care Adults, Erasmus MC

03-2004 to 10-2013 : Chair department of Intensive Care Adults Erasmus MC University Medical Center Rotterdam

02-2015-02-2016 : Vice-Chair Fellow Program Intensive Care Adults 10-2013 –02-2016 : Vice-chair department of Intensive Care Adults Erasmus MC

University Medical Center Rotterdam 01-2011 – 08-2015 : Member Supervisory Board Talma Haven Nursing Home Urk Hospital : Erasmus MC University Medical Center Department : Intensive Care Adults and Center for Home Ventilation Positions 03-2004 – 10-2013 : Chair Department of Intensive Care Adults 10-2013 – 02-2016 : Vice-Chair Department of Intensive Care Adults and Home

Ventilation

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02-2016 – current : Intensivist Erasmus MC University Medical Center Rotterdam 03-2005 – current : Professor of Medicine Erasmus University Rotterdam 05-2014 – current : Professor at University Pontificia Universidad Cathólica de

Chili, Santiago 03-2016 – current : Adjunct professor Columbia University Medical Center, Dept

of Pulmonary and Critical Care, New York, USA 08-2016 – current : Associate professor New York University, Dept of Pulmonary,

Sleep Medicine and Critical Care, New York, USA EDITOR JOURNALS AND EDITORIAL BOARD MEMBERSHIP Editor-in-Chief 01-2018 – current : Journal of Critical Care (Elsevier) Editor 2005 – 2018 : Section Editor Netherlands Journal of Critical Care 2013 – 2016 : Section Editor Intensive Care Medicine Editorial Board

1998 – 2001 : Editorial board NVIC-Monitor (NL) 1996 – 2012 : Editorial board Intensive Care Monitor (NL) 2001 – current : Editorial board Journal of Critical Care (USA) 2012 – current : Editorial Board Journal of the Turkish Society of

Anesthesiology and Reanimation 2006 – current : Editorial board Reista Brasileira de Terapia Intensivia (Brasil) 2014 – current : Editorial board ICU Management (UK) 2014 – current : Editorial board Journal of Intensive Care (Japan) 2014 – current : Journal of Acute Disease (China) 2018 – current : Editorial board Netherlands Journal of Critical Care 2018 – current : Editorial board Critical Care (London)

COMMITTEES AND WORKING GROUPS Gelre ziekenhuizen Lukas Hospital Apeldoorn 1997 – 2001 : Research and Science committee (chairman) 1996 – 2001 : Trauma committee (board member) 1997 – 2001 : Resuscitation committee (board member) Isala klinieken Zwolle 2001 – 2004 : Hospital committee on Intensive Care 2002 – 2004 : Different committees on organizational changes Erasmus MC Rotterdam 2008 – 2013 : Member Hospital committee End of Life decisions 2008 – 2011 : Member Hospital committee Medical Gasses 2010 – 2011 : Chair Tender committee mechanical ventilators 2009 – 2013 : Member Hospital committee Patient Safety 2010 – 2014 : Project chair Hospital Rapid Response Team 2013 – 2014 : Project chair Hospital Patient Data Management System

Acute Care (OR, ED, PACU, Intensive Care Adults, Intensive Care Pediatrics, Neonatal Care)

2013 – 2014 : Chair Research Committee Monitoring Thorax Center – Intensive Care Adults – Intensive Care Children – Intensive Care Neonatology – Department of Anesthesiology

2014 – 2015 : Member Hospital Education Committee 2012 – 2015 : Tutor First Year Medical Students Erasmus University

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Rotterdam NATIONAL SOCIETIES – COMMITTEES 1994 – 1997 : Treasurer Dutch Society of Intensive Care 1997 – 2001 : President Dutch Society of Intensive Care 1995 – 2002 2009 – 2011

: Dutch Intensive Care Registration Committee for Intensive Care

1998 – 2002 : Chairman National Survey Committee on ICU capacity 1999 – 2003 : Scientific committee Dutch Intensive Care Award 1999 – 2004 : Committee on guidelines, Dutch Society of Intensive Care 2001 – 2004 : Committee on organ donation Ministry of Health 2001 – 2004 : Steering committee Intensive Care Ministry of Health 1998 – 2004 : Dutch Resuscitation Council (board member) 1998 – 2004 : Dutch Society of Internal Medicine (board member) 2001 – 2005 : Committee Dutch Society of Intensive Care: implementation

of activated Proteine C 1992 – 2009 : Foundation Venti Care (board member) 2006 – 2011 : Committee on Medium Care Dutch Society of Intensive Care INTERNATIONAL SOCIETIES – COMMITTEES 1995 – 1997 : Working Group Clinical Physiological Monitoring European

Society of Intensive Care 1998 – 1999 : Pulmonary Artery Catheter Clinical Outcomes (American

College of Chest Physicians/ American Thoracic Society/Society of Critical Care Medicine/European Society of Intensive Care Medicine)

1998 – 2001 : International working group Hemodyn, hemodynamic monitoring decision support

1998 – 2002 : Chairman Working Group on Monitoring European Society of Intensive Care Medicine

1999 – 2002 : Co-chair Section on Technology Assessment European Society of Intensive Care Medicine

10-2017 – current Deputy chair Cardiovascular Dynamics Section European Society of Intensive Care Medicine

10-2017 – current Member Research Committee European Society of Intensive Care Medicine

02-2018 – current : Member Post Graduate and Fellowship Education Committee. Society of Critical Care Medicine

11-2017 – current : Member Burnout Action Planning Group American Thoracic Society

INTERNATIONAL ADVISORY BOARDS 1997 – 1998 : International study group on regional CO2 monitoring during

high risk surgery (Tonometrics, Finland) 2000 – 2003 : European Advisory Board on Education in Hemodynamics.

Edwards Healthcare 2003 – 2004 : Global advisory board on sepsis (GlaxoSmthKline) 2001 – 2008 : Remifentanyl in the ICU (GlaxoSmthKline) 2000 – 2008 : Activated Proteine C in severe sepsis (Eli Lilly) 2008 – 2011 : Applied Phsyiology Ltd Autralia 2008 – 2011 : Cheetah Israel 2009 – 2011 : Hutchinson Technology USA 2013 – current : Nestle Switserland 2014 : 3M St. Paul (MI)

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2015 – current : Radiometer Denmark 2015 – current : Grifols Spain ORGANIZATION OF SCIENTIFIC MEETINGS 1999 – 2002 : Organization committee of Annual Congress and courses on

intensive care, Dutch Society of Intensive Care 2003 – 2004 : Organization committee Course on Hemodynamics for

intensivists, S.African Society of Intensive Care 1992 – 2010 : Organization committee Annual Dutch Intensive Care

Congress, Foundation Venti Care 2003 – 2004 : Organization committee Master classes on Intensive Care,

UK 2003 – 2014 : Annual 5-day Winter Workshop Intensive Care for Dutch

intensivists 2013 – current : Scientific committee annual International Symposium on

Emergency Medicine and Intensive Care, Brussels EDUCATIONAL – TRAINING PROGRAMS 1993 – 2001 : Ambulance service educational program 1995 – 2001 : Educational program Gelre ziekenhuizen 1997 – 2000 : Evidence Based Medicine Gelre ziekenhuizen Lukas Hospital

(bi-annual course) 1998 and 1999 : 5day Course on Intensive Care Sao Paulo Brazil 2000 – 2003 : European Educational program on Hemodynamic monitoring.

Edwards Healthcare 2000 – 2003 : PACT program European Society on Intensive Care Medicine:

Module on hemodynamic monitoring 2012 : PACT update program European Society on Intensive Care

Medicine: Module on hemodynamic monitoring INTERNATIONAL INVITATIONAL WORKING CONFERENCES 1999 : SCCM: Working conference Education in Pulmonary Artery

Catheterization, Phoenix USA 1999 – 2001 : European Society of Intensive Care Medicine: Section

Technology Assessment yearly working conference: Monitoring, Organ Failure, Life Support Systems

2006 : European Society of Intensive Care: Guidelines for hemodynamic monitoring

2013 – 2014 : European Society of Intensive Care: Update Guideline for shock and hemodynamic monitoring

2015 – current : European Society of Intensive Care: Guideline for fluid resuscitation in limited resource situations

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MEMBERSHIP SOCIETIES Dutch Society of Internal Medicine Society of Critical Care Medicine (U.S.A.) European Society of Intensive Care Medicine European Society of Anesthesiology American College of Chest Physicians American Physiology Society American Thoracic Society RESEARCH National and International Industry Sponsored Studies Steering committee 2008 Hemoximer (PHP) Phase III Study, Curacyte AG Germany MicroSoap Study: Worldwide incidence of an abnormal microcirculation Local principal investigator IL1-ra in sepsis patients phase III (completed) aTNF in severe sepsis phase III (completed) 546C88 in septic shock phase II and phase III (completed) aPAF in severe sepsis phase II (completed) activated Proteine C in severe sepsis Phase (audited by European Inspection) (completed) r-TFPI in severe sepsis phase IIa-II-III (completed) CD-14 antibodies in severe sepsis phase II (completed) ATIII in sever sepsis phase III (completed) TLC-C-53 in patients with ARDS phase II (completed) Tonocap study in major elective surgery phase II (completed) MicroSOAP study. Worldwide study on the incidence of abnormal microcirculation (completed) National study on the incidence of abnormal StO2 (completed)

National principal investigator r-TFPI in severe sepsis phase III (completed) rPAF-ah in severe sepsis phase III (completed) Open label activated Proteine C in severe sepsis (completed) Remifentanil sedation in critically ill patients (completed) FENICE study European Society of Intensive Care (completed) (Inter)National and local private-government sponsored studies Clinical utility of a hand held lactate measurement device (Foundation “Drie Lichten”) (completed) Lacprog – lactate levels in acutely admitted patients (private funding) (completed) Regional immune activation in elective aortic surgery (private funding) (completed) Peripheral Perfusion Index in healthy volunteers and critically ill patients (private funding) (completed) Capacity problems in intensive care in the Netherlands (Funded by Ministry of Health) National and local principal investigator (completed) Vasopressin levels and treatment in circulatory shock (private funding) (completed) ELDICUS – Triage decisions in the elderly (Funded by European Union) National and local principal investigator (completed) Peripheral circulation as a measure of global oxygenation (Grant from Philips Medical Systems USA) (completed) Quality of life in critically ill patients (private funding) (completed) FABRA: Improving number of potential organ donors in brain dead patients. Government funded (completed) MicroSOAP: prevalence of abnormal microcirculation in critically ill (Erasmus MC, AMC Amsterdam funding, completed) Family centered care (Erasmus MC sponsored, running) Implementation of delirium guidelines (Government funded, running) Multicenter study on end-of-life care in the Netherlands (Erasmus MC sponsored, running) Tissue oxygenation and lactate clearance in a model of septic shock (Sponsored by Government Chili and Maquet, running)

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Drug clearance in an experimental model of ECMO (Sponsored by Government Chili and Astellas) Effect of dexmedetomidine on Sympathetic Nervous System activiation in critically ill patients. Dept of Anesthesiology Columbia University Medical Center New York (Vivek Moitra, running) Effect of vasoactive medication on liver perfusion and functional liver blood flow in liver surgery. Dept of Anesthesiology Columbia University Medical Center New York (Gebhard Wagener, running) Intra-organ arterial resistance and peripheral circulation in critically ill patients (Erasmus MC sponsored) (Angela Somnese, University Hospital Naples, Italy) ABSES study, European Society of Intensive Care ANDROMEDA study in Latin America: Early Goal Directed Therapy in Septic Shock: Peripheral circulation vs lactate. PHD PROGRAMS (PROMOTER) Finished 1. Jose Hofhuis, RN: Quality of life in critically ill patients (2008) 2. Tim Jansen MD: Value of lactate monitoring in clinical practice (2010) 3. Yorick de Groot MD: Organ donation (2012) 4. Bas Bartels MD: Blood transfusion and the microcirculation (2012) 5. Iwan Meynaar MD: Improving decision making in Intensive Care (2012) 6. Alex Pinto de Lima MD: Peripheral circulation as a measure of global oxygenation (2013) 7. Hilde de Geus MD: NGAL and AKI in critically ill patients (2013) 8. Glenn Hernandez MD: Holistic view on hemodynamic monitoring (2013) 9. Michel van Genderen: Peripheral perfusion in relation to systemic hemodynamics and its importance in

critically ill patients (2015) 10. Eva Klein MD: The Additional Value of Microcirculatory Imaging in Critically Ill Patients and its Relation to

Systemic Hemodynamics (2015) 11. Jelle Epker MD: Death and dying in the intensive care unit; practical issues and ethical dilemmas from a

Dutch perspective (2015) 12. Margot van Mol RN: Balancing Coincident Worlds. the emotional impact of patients’ relatives and

professionals in the intensive care (2017) Current Ben v.d. Hoven MD: Nonivasive assessment of Functional Liver Bloodflow Zoran Trogrlic RN: Implementation research on delirium guidelines Loek Meijs MD: Guyton circulation Esther van der Zee: Ethics in admission and discharge Maike Hiller: Economic consequences of delayed ICU discharge PHD EXAMINATION/DEFENCE COMMITTEES University of Ghent (Belgium) Free University of Amsterdam University of Amsterdam University of Nijmegen University Groningen Erasmus University Rotterdam Technical University Twente, Enschede Technical University Delft EXTERNAL REFEREE FULL PROFESSOR POSITION Pontificia Universidad Católica de Chile 2016, 2017, 2017

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CITATION INDEX

Google scolar Website: https://scholar.google.nl/citations?hl=en&user=mcbQn-0AAAAJ Citation Index All Since 2013

Citations 11.852 6571 h-index 59 42 i10-index 139 118

Updated: March 2018

Research Gate Citation Indices All Remark RG Score 47.59 score is higher than 97.5% of Research Gate members h-index 49 Publication reads 33,930 Citations 9,955 Updated: March 2018

Researcher ID Citation Indices All Total articles 231 h-index 40 Sum of times cited 6263 Average citation per article 32.45 Updated: March 2018

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PUBLICATIONS 1. J.Bakker. Cardiale depressie tijdens septische shock. Intensive Care Review 1990;5:122-123J.Bakker.

Summary 10 th International symposium on Intensive Care and Emergency Medicine. Tijdschrift voor Cardiologie 1990;2:203-208

2. J.Bakker. Cardiale depressie tijdens septische shock. Intensive Care Review 1990;5:122-123 3. J.Bakker, F.v.Kersen, J.Bellaar Spruyt. Pneumopericardium and pneumomediastinum after polypectomy.

Endoscopy 1991;23:46-47 4. J.Bakker, J-L.Vincent. The oxygen supply dependency phenomenon is associated with increased blood

lactate levels. J Crit Care 1991;6:152-159 5. J.Bakker, M.Coffernils, M.Leon, P.Gris, J-L.Vincent. Blood lactate levels are superior to oxygen derived

variables in predicting outcome in human septic shock. Chest 1991;99:956-963 6. J.Bakker, J-L.Vincent, P.Gris, M.Leon, M.Coffernils, R.J.Kahn. Veno-arterial carbon dioxide gradient in

human septic shock. Chest 1992;101:509-515 7. J-L.Vincent, J.Bakker, P.G.Silance, G.Berlot. Oxygen transport in the critically ill. IV Giornate Internazionali

di Rianimazione. 1992; 41 - 44 8. J-L.Vincent, J.Bakker, G.Marécaux, L.Schandene, R.J.Kahn, E.Dupont. Administration of anti-TNF antibody

improves left ventricular function in septic shock patients: Results of a pilot study. Chest 1992;101:810-815 9. C.Routsi, J-L.Vincent, J.Bakker, D.de Backer, P. Lejeune, A.d'Hollander et al. Relation between oxygen

consumption and oxygen delivery in patients after cardiac surgery. Anesth Analg 1993;77:1104-1110 10. J.Bakker, J-L.Vincent. The effects of norepinephrine and dobutamine on oxygen transport and consumption

in a dog model of endotoxic shock. Crit Care Med 1993; 21: 524-532 11. J.Bakker, H.Zhang, M.Dupieurreux, S. van Asbeck, J-L Vincent. N-Acetylcysteine improves tissue

oxygenation in a dog model of endotoxin shock. J Crit Care 1994;9:236-243 12. J.Bakker. Shock: een praktisch probleem deel 1. De praktijk van shock aan de hand van casuistiek. Kritiek

1994;12.2:9-10. 13. J.Bakker. Shock: een praktisch probleem deel 2. De praktijk van shock aan de hand van casuistiek. Kritiek

1994;12.3:9-12 14. J.Bakker. Shock: een praktisch probleem deel 3. De praktijk van shock aan de hand van casuistiek. Kritiek

1994;12.4: 22-24 15. J.Bakker. Shock: een praktisch probleem deel 4. De praktijk van shock aan de hand van casuistiek. Kritiek

1994;12.5: 13-16 16. J.H.Rommes, J.Bakker. De ventilatoire en hemodynamische veranderingen als gevolg van een

spanningspneumothorax. Kritiek 1994;12:20-23 17. H.Zhang, H.Spapen, DN.Nguyen, P.Rogiers, J.Bakker, J-L. Vincent. Effects of N-acetylcysteine on regional

blood flow during endotoxic shock. Eur Surg Res 1995;27:292-300 18. E.C.Boerma, J.H. Rommes, R.van Leeuwen, J.Bakker. Cardiac arrest as a clue to a 3,4 diaminopyridine

intoxication in a patient with Lambert-Eaton myasthenic syndrome. J Clin Toxicol 1995;33:249-251 19. P. Van der Linden, I. Rausin, A. Deltell, Y. Bekrar, E. Gilbart, J. Bakker, and J. L. Vincent. Detection of tissue

hypoxia by arterio-venous gradient for PCO2 and pH in anesthetized dogs during progressive hemorrhage. Anesth Analg 1995;80 (2):269-275

20. J.Bakker, M.Leon, M.Coffernils, Ph.Gris, RJ.Kahn, J-L.Vincent. Serial blood lactate levels can predict multiple system organ failure in septic shock patients. Am J Surg 1996;171:221-226

21. J.Bakker, J.H. Rommes. Rechter Ventrikel Ejectiefractie bij Intensive Care patiënten. Ned Tijdschr Geneeskd 1996;140:2498-2502

22. J. Bakker. Monitoring of Blood lactate levels. Int Journal of Intensive Care 1996;3:29-36 23. S.E. Geerlings, J.H.Rommes, D.W.van Toorn, J.Bakker. Acute Folate deficiency in a critically ill patient. Neth

Journal Med 1997;51:36-38 24. J.Bakker. Nieuwe behandelingsstrategien van sepsis en septische shock. Kritiek 1997;4:23-25 25. J. Bakker. Oxygen transport in the critically ill. Int J Intensive Care 1997;4:27 26. K Reinhart, P Radermacher, CL Sprung, D Phelan, J Bakker, H Steltzer. PA catherization – quo vadis?

Intensive Care Med 1997;23:605-609

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27. E. Raaymakers, Th.J.C. Faes, J.M. Meijer, P.W.A. Kunst, J.Bakker, H.G. Goovaerts, R.M. Heethaar. Estimation of non-cardiogenic pulmonary oedema using dual frequency electrical impedance. Med & Biol Eng & Comp 1998;36:461-466

28. J. Bakker, J.H. Rommes. Quality of care for elderly patients with pneumonia. JAMA 1998;279:1950-1951 29. E. Raaymakers, Th.J.C. Faes, P.W.A. Kunst, J.Bakker, H.G. Goovaerts, R.M. Heethaar. The influence of

extravascular lung water on cardiac output measurements. Physiol Meas 1998;19:491-499 30. W.Brinkert, J.Bakker. Tonometry: what is it and what is it for? AINS 1998;33:1-4 31. J. Bakker. Cost-effectiveness in Intensive Care Medicine. J Anästhesie und Intensivbehandlung

1998;5:S10-S12 32. W.Brinkert, J.Bakker. Is it time to abandon the pHi concept? Int J Intensive Care 1998;5:16-21 33. J.Bakker. P de Munck A clinical information system for the intensive care. Int J Intensive Care 1998;5:S67-

S70 34. J. Bakker, F. van Os, R. Ton. Autorisatie van ambulanceverpleegkundigen. NTSR 1998;19-5;32-35 35. P.W.A.Kunst, P.M.J.M.de Vries, P.E.Postmus,J.Bakker. Evaluation of electrical impedance tomography in the

measurement of PEEP-induced changes in lung volume. Chest 1999;115:1102-1106 36. W. Brinkert, J. Bakker. Home blood glucose monitoring. Lancet 1999;354:252 37. W. Brinkert, J.H. Rommes, J. Bakker. Lactate measurements in critically ill patients with a hand-held analyser.

Intensive Care Med 1999;25:966-969 38. P.W.A. Kunst, A. Vonk Noordegraaf, E. Raaijmakers, J. Bakker, A.B.J. Groeneveld, P.E. Postmus,

P.M.J.M.de Vries. Electrical impedance tomography in the assessment of extravascular lung water in noncardiogenic acute respiratory failure. Chest 1999;116:1695-1702

39. J. Bakker, J.H. Rommes. Epinephrine for out-of-hospital cardiac arrest. N Engl J Med 1999;340:1763-1764 40. J. Hofhuis, J. Bakker. Experiences of critically ill patients in the ICU: what do they think of us? Int J Intensive

Care 1999;5:114-117 41. J. Bakker. Blood lactate levels. Current Opinion in Critical Care 1999;5:234-239 42. J. Laki, J. Bakker. Treatment of massive pulmonary embolism with heparine and thrombolytics. Intensive

Care Monitor 1999;4:11-12 43. J Bakker, JVS Vos. Costs of implementing new therapies: What is the scope? Intensive Care Monitor

1999;6:101 44. P. Beelen, J. Bakker. Actieve bevochtiging tijdens beademing. Intensive Care Monitor 1999;5:15-16 45. J. Bakker. Vraag naar Intensivisten in 1998 – 1999. Intensive Care Monitor 1999;3(6):8-9 46. J.Bakker, S.J.M. Schieveld, W. Brinkert. Serumlactaatconcentratie als maat voor weefselhypoxie bij ernstig

zieke patienten. Ned Tijdschr Geneeskd 2000;144(16):737-741 47. J. Bakker. Lactate: May I have your votes please. Intensive Care Med 2000;27:6-11 48. DeBacker D, Bakker J, Bernard G, Carlet J, Marshall J, Sprung CL, Vincent J-L. Case Presentation: Dr.

Jaques Creteur. Sepsis 2000 4(1):49-56 49. J.Bakker, E.J. van Lieshout. Transport of critically ill patients: We can do better!. Neth J Med 2000;57:177-

179 50. J.L Vincent, H. Spapen, J.Bakker, et al. Phase II multicenter clinical study of the platelet-activating factor

receptor antagonist BB-882 in the treatment of sepsis. Crit Care Med 2000;28:638-642 51. P. Beelen, J. Bakker, J.H. Rommes. Ademgasbevochtiging tijdens mechanische beademing. Kritiek

2000;18(1):19-28 52. J.Bakker. Large databases to answer the question. Intensive Care Monitor 2000;7(4):61 53. J.Bakker, J.H. Hubben, A.R.H. van Zanten, J. Damen. Criteria voor opname en ontslag van Intensive Care

afdelingen in Nederland. Intensive Care Monitor 2000;4(6):V-VIII 54. RJ Lieverse, J. van Hoofd, G. Fedder, J. Bakker, F. Heilman. Necrotising enterocolitis in a couple due to

staphylococcal toxin. Eur J Gastroenterol 2001;13:595-597 55. ARH van Zanten, J.Bakker, PCM van den Berg, ARJ Girbes, SJ van Leeuwen. Geactiveerd proteine C

toediening tijdens ernstige sepsis. Ned Tijdschr Geneeskd 2001;24:1179 56. AJP Schrijvers, J Hautvast, DE Grobbee, J Bakker. Intensive Care Units are also Public Health facilities. Br

Med J 2001;322(7297):1261 57. J. Bakker. Ziekenhuisinfecties en risicofactoren op de intensive-careafdelingen van 16 Nederlandse

ziekenhuizen; resultaten van surveillance als indicator voor zorgkwaliteit. Ned Tijdschr Geneeskd 2001;34:1665

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58. ARH van Zanten, J Bakker, ARJ Girbes. Report on the NVIC symposium technology assessment in critical care. Intensive Care Monitor 2001:

59. J. Bakker, J. Damen. To Swan or not to Swan? That remains the question. Intensive Care Monitor 2001; 60. J. van Remmen, J.Bakker. Non-invasive positive pressure ventilation in acute cardiogenic pulmonary edema:

Comprendo? Intensive Care Monitor 2001;8(2):21 61. Pinto Lima, P. Beelen, J. Bakker. Use of a peripheral perfusion index derived from the pulse oximetry signal

as a non-invasive indicator of perfusion. Crit Care Med 2002;30:1210-1213 62. S. Kasaoka, T. Maekawa, J. Bakker. Diagnose in beeld: Traumatisch schedel-hersenletsel. Ned Tijdschr

Geneeskd 2002;146:2234 63. J.Damen, D.van Diejen, J.Bakker, A.R.H.van Zanten. NVIC richtlijnen en de juridische implicaties.

Netherlands Journal of Critical Care 2002;6(2):18-21 64. J.Damen, D. van Diejen, J. Bakker, A.R.H. van Zanten: NVIC-standpunten, NVIC-richtlijnen en juridische

implicaties. Netherlands Journal of Critical Care 6 (2): 18-22, 2002 65. J. Damen, A.P.Nierich, J. Bakker, A.R.H. van Zanten. De hemodynamische gevolgen van ernstige sepsis:

pathofysiologie en een richtlijn voor de behandeling. Netherlands Journal of Critical Care 2002 6(3):19-29 66. J.Damen, H.J.van Leeuwen, A.R.H. van Zanten, J.Bakker. Verbeteren klinische richtlijnen de kwaliteit van

zorg op de intensive care? Netherlands Journal of Critical Care 2002; 6(3):30-46 67. J.Damen, J.Bakker, H.J.van Leeuwen, A.R.H.van Zanten. De evaluatie van NVIC-richtlijnen. Netherlands

Journal of Critical Care 2002;6(4):21-23 68. J.Damen, J.Bakker,A.R.H. van Zanten. Beoordeling van aanbevelingsniveau’s in de richtlijnen van de NVIC.

Netherlands Journal of Critical Care 2002;6(5):32-33 69. A.R.J. Girbes, J.Bakker, M.van Deuren, S.J. van Leeuwen, A.R.H. van Zanten. NVIC conceptrichtlijn

toepassing drotrecogin alpha, geactiveerd proteine C (aPC) bij de behandeling van ernstige sepsis. Netherlands Journal of Critical Care 2002;6(5);41-45

70. J. Bakker, J. Damen, ARH van Zanten, JH Hubben. Criteria voor opname en ontslag van intensive care afdelingen in Nederland. Ned Tijdschr v Geneeskd 2003;147:110-115

71. P. Squara, E. Fourquet, L. Jacquet, A. Broccard, T. Uhlig, A. Rhodes, J. Bakker, C. Perret. Usefulness of an expert software for hemodynamic evaluation: Results of the Hemodyn survey. Intensive Care Med;2003;29:735-741

72. J. Hofhuis, J.L.A. Hautvast, A.J.P. Schrijvers, J. Bakker. Quality of life on admission to the Intensive Care: can we query the relatives? Intensive Care Med 2003;29:974-979

73. J. Damen, D. van Diejen, J. Bakker, AR van Zanten. Legal implications of clinical practice guidelines. Intensive Care Medicine 2003;29:3-7

74. J.F. Dhainaut, P.F. Laterre, J.M. Janes, G.R. Bernard, A. Artigas, J. Bakker et al. Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple organ dysfunction: Data from the PROWESS trial. Intensive Care Med 2003;29:894-903

75. J. Bakker,R. Grover, A. MCLuckie, L. Holzapfel, J. Andersson, R. Lodato et al. The nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) promotes the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (144-002). Crit Care Med 2004;32(1);1-12

76. Lopez, J.A. Lorente, J. Steingrub, J. Bakker, A. MCLuckie, S. Willats et al. A multi-center, randomized, placebo-controlled, double blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock. Crit Care Med 2004;32(1):21-30

77. J.Bakker and A.P. de Lima. Increased blood lactate levels: an important warning signal in surgical practice. Crit Care 2004;8(2):96-98

78. J.Bakker, M Levi, B van Hout, A van Gestel. Sepsis, een gecompliceerd syndroom met belangrijke medische en maatschappelijke consequenties (Ned Tijdschr Geneeskd 2004

79. van Gestel, J. Bakker, C. Veraart, B.A. van Hout. Prevalence and incidence of severe sepsis in Dutch Intensive Care Units. Crit Care 2004

80. G Lebuffe, B Vallet, J Takala, G Hartstein, M Lamy, M Mythen, J Bakker, D Bennett, O Boyd, A Webb. A European, multicenter, observational study to assess the value of gastric-to-end tidal PCO2 difference in predicting postoperative complication. Anesth Analg 2004;99:166-172

81. J.G.M. Hofhuis, J.Bakker, P.E.Spronk. Is there quality of life after intensive care? Netherlands Journal of Critical Care 2004;8(2);111-113

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82. Reinhart K, Gluck T, Ligtenberg J, Tschaikowsky K, Bruining A, Bakker J et al. CD14 receptor occupancy in severe sepsis: Results of a Phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med 2004;32:1100-1108

83. Lima, J. Bakker. Noninvasive monitoring of peripheral perfusion. Intensive Care Med 2005;31(10):1316-26 84. Bakker J. Therapeutic dilemmas in patients with a centrally-located pulmonary embolism confirmed by spiral

CT-scan but with no cardiogenic shock. Ned Tijdschr Geneesk 2005;149(41): 2310 85. Geus de HR, Bakker J. Those who do not remember the past are condemned to repeat it. Intensive Care

Monitor 2005;12(5):81-82 86. Bakker J, Geus de HR. One more time: the pulmonary artery catheter. Netherlands Journal of Critical Care

2005;9(6):341-342 87. Bakker J. The abdominal compartiment syndrome. Ned Tijdschr Geneesk 2005;149(41):2310 88. Kompanje EJO, Bakker J et al. Organ donations and unused potential donations in traumatic brain injury,

subarachnioid haemorrhage and intracerebral haemorrhage. Intensive Care Med 2006;32(2):217-22 89. Kompanje EJO, Bakker J et al. Reply to “Organ donation in pediatric traumatic brain injury” Intensive Care

Med 2006;32(9):1448 90. Kompanje EJ, Vrakking AM, Bakker J. End-of-life decisions in seriously ill patients: the position of intensive

care nurses. Ned Tijdschr Geneesk 2006;150(50-):2787-2788 91. Verweel EJ, Le Noble J, Thijsse WT, Bakker J. A patient with headache, apraxie and loss of initiative.

Netherlands Journal of Critical Care 2006;10(3);436 92. De Geus HRH, Bakker J. Incomplete circle of Willis. Netherlands Journal of Critical Care 2006;10(5);530 93. Jansen, TC, Bakker J. Why measure lactate on the ICU? Netherlands Journal of Critical Care

2006;10(6);618-621 94. Bakker J. Het waarom van de Intensive Care. Netherlands Journal of Critical Care 2006;10(3);457-464 95. Van Fessem, Bakker J. Structured abstract: Comparison of two fluid-management strategies in acute lung

inhuur (N Engl J Med 2006;354:2564-75). Netherlands Journal of Critical Care 2006;10(6);631 96. M van Houdenhoven, TD Nguyen, MJ Eijkemans, EW Steyerberg, HW Tilanus, D Gommers, G Wullink, J

Bakker, G Kazemier. Optimizing intensive care capacity using individual lengt-of-stay prediction models. Crit Care 2007;11:R42

97. TC Jansen, EJO Kompanje, C Druml, DK Menon, CJ Wiedermann, J Bakker. Deferred consent in emergency intensive care research: what if the patient dies early? Use the data or not?. Intensive Care Med 2007;33(5):894-900

98. TC Jansen, J Bakker. How do I use venous saturations? Neth J Crit Care 2007;11(3):141-144 99. JGM Hofhuis, PE Spronk, HF van Stel, AJP Schrijvers, JH Rommes, J Bakker. Quality of life before intensive

care unit admission is a predictor of survival. Crit Care 2007;11:R78 100. Jansen TC, Kompanje EJ, Druml C, Menon DK, Wiedermann CJ, Bakker J. Reply to moser and roggla.

Intensive Care Med. Aug 2007;33(8):1484. 101. Vrakking AM, Kompanje EJ, Bakker J. Comment on "Attitudes of European physicians, nurses, patients, and

families regarding end-of-life decisions: the ETHICATT study" by Sprung et al. Intensive Care Med. Apr 2007;33(4):747; author reply 748.

102. HR de Geus, B van der Hoven, J Bakker. Aspiration pneumonia with Lactobacillus murinus and Enterobacter cloacae in a critically ill patient. Neth J Crit Care 2007;11(4):196-197

103. Jansen TC, Kompanje EJ, Druml C, Menon DK, Wiedermann CJ, Bakker J. Deferred consent in emergency intensive care research: what if the patient dies early? Use the data or not? Intensive Care Med. May 2007;33(5):894-900.

104. EJO Kompanje, ID de Beaufort, J Bakker. Euthanasia in intensive care: A 56-year old man with a Pontine Hemorrhage resulting in a locket-in syndrome. Crit Care Med 2007;35(10):2428-2430

105. EJO Kompanje, TC Jansen, B van der Hoven, J Bakker. The first description of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843. Intensive Care Med 2007;33(11):1967-1971

106. Bakker J, Jansen TC. Don't take vitals, take a lactate. Intensive Care Med. 2007;33(11):1863-18645 107. Van Houdenhoven M, Van Oostrum JM, Wullink G, Hans E, Hurink JL, Bakker J, Kazemier G. Optimizing

intensive care capacity using individual length-of-stay prediction models. Crit Care 2007;11(2):R42 108. JGM Hofhuis, PE Spronk, HF van Stel, AJP Schrijvers, JH Rommes, J Bakker. Effect of criticall illness on

perceived health related quality of life during ICU treatment, hospital stay, and after hospital discharge; a long term follow-up study. Chest 2008;133(2):377-385

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109. Tan SS, Hakkaart-van Roijen L, Bouwmans CA, Hoogendoorn ME, Spronk PE, Bakker J. A microcosting study of intensive care unit stay in the Netherlands. J Intensive Care 2008;23(4):250-257

110. D Gommers, J Bakker. Medications for analgesia and sedation in in the intensive care unit: an overview. Crit Care 2008;12(Suppl 3):S4

111. J Bakker, TC Jansen, A Lima, EJO Kompanje. Why opiods and sedatives prolong life rather than hasten death after ventilator withdrawal in critically ill patients. Am J Hospic Pall Med 2008;25(2):152-154

112. EJO Kompanje, B van der Hoven, J Bakker. Anticipation on distressing symptoms after discontinuation of mechanical ventilation in intensive care at the end of life. Intensive Care Med 2008;34(9):1593-1599

113. EJ Kompanje, TC Jansen, J Bakker, L van Zuylen. The crystal ball in end-of-life care. Crit Care Med 2008;26(8):2482

114. Ido G Bikker, Jasper van Bommel, Dinis dos Reis Miranda, Jan Bakker, Diederik Gommers. End-expiratory lung volume during mechanical ventilation: a comparison to reference values and the effect of PEEP in ICU patients with different lung conditions. Critical Care 2008, 12:R145

115. E.Klijn, CA den Uil, J.Bakker, C.Ince. The heterogeneity of the microcirculation in critical illness. Clin Chest Med 2008; 29(4):643-653

116. TC Jansen, J van Bommel, PG Mulder, JH Rommes, SJ Schieveld, J Bakker. The prognostic value of blood lactate levels relative to that of vital signs in the pre-hospital setting: a pilot study. Crit Care 2008;12(6):R160

117. EJ Kompanje, TC Jansen, JL Le Noble, HR de Geus, J Bakker. Deferred consent for inclusion of patients unable to give their consent in studies in the field of emergency medicine. Nederlands tijdschrift voor geneeskunde 2008 vol. 152 (38) pp. 2057-61

118. RW Rozendaal, PE Spronk, FF Snellen, A Schoen, ARH van Zanten, NA Foudraine, PGH Mulder, J Bakker. Remifentanil-based analgo-sedation shortens duration of ventilation, weaning time, and intensive care unit length of stay compared to conventional sedation and analgesia. Results of a centre-randomized, open-label, crossover study. Intensive Care Med 2009;35(2):291-298

119. TC Jansen, J van Bommel, PG Mulder, AP Lima, B van der Hoven, JH Rommes, FTF Snellen, J Bakker. Prognostic value of blood lactate levels: does the clinical diagnosis at admission matter? J Trauma 2009;66(2):377-385

120. A Lima, TC Jansen, J van Bommel, C Ince, J Bakker. The prognostic value of the subjective assessment of peripheral perfusion in critically ill patients. Crit Care Med 2009;37(3):934-938

121. TC Jansen, EJ Kompanje, J Bakker. Deferred proxy consent in emergency critical care research: ethically valid and practically feasable. Crit Care Med 2009;37(Suppl 1):S65-S68

122. TC Jansen, J van Bommel, J Bakker. Blood lactate monitoring in critically ill patients: A health technology assessment. Crit Care Med;37(4):2827-2939

123. IG Bikker, S Leonhardt, J Bakker, D Gommers. Lung volume calculated from electrical impedance tomography in ICU patients at different PEEP levels. Intensive Care Med (2009) vol. 35 (8) pp. 1362-7

124. TC Jansen, J van Bommel, R Woodward, PGH Mulder, J Bakker. Association between blood lactate levels, Sequential Organ Failure Assessment subscores, and 28-day mortality during early and late intensive care unit stay: a retrospective observational study. Crit Care Med. (2009) vol. 37 (8) pp. 2369-74

125. J Hofhuis, H van Stel, AJP Schrijvers, J Rommes, J Bakker, P Spronk. Conceptual issues specifically related to health-related quality of life in critically ill patients. Critical Care (2009) vol. 13 (1) pp. 118

126. A Lima, J van Bommel, TC Jansen, C Ince, J Bakker. Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients. Critical Care (2009) vol. 13 Suppl 5 pp. S13

127. IG Bikker, TV Scohy, AJJC Bogers, J Bakker, D Gommers. Measurement of en-expiratory lung volume in intubated children without interruption of mechanical ventilation. Intensive Care Med 2009;35(10):1749-1753

128. AF De Jong, EJO Kompanje, JGM Hofhuis, PE Spronk, AJP Schrijvers, J Bakker. Functional status after intensive care. J Rehabil Med 2009;41(9):780

129. R Bezemer, A Lima, D Myers, E Klijn, M Heger, PT Goedhart, J Bakker, C Ince. Assessment of tissue oxygen saturation during a vascular occlusion test using near-infrared spectroscopy: the role of probe spacing and measurement site studied in healthy volunteers. Crit Care 2009;13(Suppl 5):54

130. J Hofhuis, H van Stel, AJP Schrijvers, J Rommes, J Bakker, P Spronk. Health-related quality of life in critically ill patients: how to score and what is the clinical impact? Curr Opinion Crit Care 2009;15(5):425-430

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2010 131. B van der Hoven, H van Pelt, EL Swart, F Bonthuis, HW Tilanus, J Bakker, D Gommers. Noninvasive

functional liver blood flow measurement: comparision between bolus and steady-state clearance of sorbitol in a small-rodent model. Physiol Gastrointest Liver Physiol 2010;298(2):G177-G181

132. J Epker, J Bakker. Accidental methanol ingestion: Case Report. BMC Emergency Medicine 2010;10:3 133. de Groot YJ, Jansen NE, Bakker J, Kuiper MA, Aerdts S, Maas AI, Wijdicks EF, van Leiden HA, Hoitsma AJ,

Kremer BH, Kompanje EJ. Imminent brain death: point of departure for potential heart-beating organ donor recognition. Intensive Care Med 2010;36(9):1488-1494

134. TC Jansen, J van Bommel, FJ Schoonderbeek, SJ Sleeswijk Visser, JM van der Klooster, AP Lima, SP Willemsen, J Bakker. Early lactate-guided therapy in ICU patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 2010;182:752-761

135. Maiwenn J Al, Leona Hakkaart, Siok Swan Tan and Jan Bakker. Cost-consequence analysis of remifentanil-based analgo-sedation vs. conventional analgesia and sedation for patients on mechanical ventilation in the Netherlands. Critical Care 2010, 14:R195

136. AHM Knook, R Baak, J Epker, J Bakker. First experiences in the Netherlands with a new single catheter-based veno-venous extracorporeal carbon dioxide removal system. Neth J Crit Care 2011;15(1):24-26

137. AMR Tilanus, HRH de Geus, BJA Rijnders, RS Dwarkasing, B van der Hoven, J Bakker. Severe group A streptococcal toxic shock syndrome presenting as primary peritonitis: a case report and brief review of the literature. Int J Infect Dis 2010;14:E208-E212

138. H de Geus, R Mathot, B van der Hoven, M Tjoa, J Bakker. Enhanced paracetamol clearance with molecular adsorbents recirculating system (MARS) in severe autointoxication. Blood Purif 2010;30(2):118-119

139. Jansen TC, Bakker J, Kompanje EJO. Inability to obtain deferred consent due to early death in emergency research: effect on valitdity of clinical trials. Intensive Care Med 2010;36(11):1962-1965

140. Bikker, I. G., Preis, C., Egal, M., Bakker, J., & Gommers, D. Electrical impedance tomography measured at two thoracic levels can visualize the ventilation distribution changes at the bedside during a decremental positive end-expiratory lung pressure trial. Critical Care 2011;15 (4):R193.

2011 141. de Geus, H. R. H., Bakker, J., Lesaffre, E. M. E. H., & le Noble, J. L. M. L. Neutrophil gelatinase-associated

lipocalin at ICU admission predicts for acute kidney injury in adult patients. Am J Respir Crit Care Med 2011;183 (7);907–914.

142. de Geus, H. R. H., Woo, J. G., Wang, Y., Devarajan, P., Betjes, M. G., le Noble, J. L. M. L., & Bakker, J. (2011b). Urinary Neutrophil Gelatinase-Associated Lipocalin Measured on Admission to the Intensive Care Unit Accurately Discriminates between Sustained and Transient Acute Kidney Injury in Adult Critically Ill Patients. Nephron 2011;1 (1):9–23.

143. de Groot, Y. J., Bakker, J., Wijdicks, E. F. M., & Kompanje, E. J. O. (2011a). Imminent brain death and brain death are not the same: reply to Verheijde and Rady. Intensive Care Med 2011:37(1):174.

144. de Groot, Y. J., Lingsma, H. F., der Jagt, van, M., Bakker, J., Ijzermans, J. N. M., & Kompanje, E. J. O. Remarkable changes in the choice of timing to discuss organ donation with the relatives of a patient: a study in 228 organ donations in 20 years. Critical Care 2011;15(5);R235.

145. de Groot, Y. J., Wijdicks, E. F. M., der Jagt, van, M., Bakker, J., Lingsma, H. F., Ijzermans, J. N. M., & Kompanje, E. J. O. (2011). Donor conversion rates depend on the assessment tools used in the evaluation of potential organ donors. Intensive Care Medicine, 37(4), 665–670.

146. Edbrooke, D. L., Minelli, C., Mills, G. H., Iapichino, G., Pezzi, A., Corbella, D., Jacobs, P., et al. Implications of ICU triage decisions on patient mortality: a cost-effectiveness analysis. Critical Care 2011;15(1):R56.

147. Epker, J. L., Bakker, J., & Kompanje, E. J. O. The use of opioids and sedatives and time until death after withdrawing mechanical ventilation and vasoactive drugs in a Dutch intensive care unit. Anesth Analg 2011;112(3):628–634.

148. Eyssen, M. E. B., van Doorn, P. A., Jacobs, B. C., Steyerberg, E. W., der Voort, van, P. H. J., Zandstra, D. F., Horn, J., et al. Selective digestive tract decontamination decreases time on ventilator in Guillain-Barré syndrome. Neurocritical Care, 2011;15(1), 128–133.

149. Kompanje, E. J. O., de Groot, Y. J., & Bakker, J. Is organ donation from brain dead donors reaching an inescapable and desirable nadir? Transplantation 2011;91(11):1177–1180.

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150. Kompanje, E. J. O., de Groot, Y. J., Bakker, J., & IJzermans, J. N. M. (2011b). A National Multicenter Trial on Family Presence During Brain Death Determination: The FABRA Study. Neurocritical Care 2011;

151. Lima, A., van Bommel, J., Sikorska, K., Van Genderen, M., Klijn, E., Lesaffre, E., Ince, C., et al.. The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients. Crit Care Med 2011;39(7):1649–1654.

152. Van Genderen, M., Gommers, D., Klijn, E., Lima, A., Bakker, J., & van Bommel, J. (2011). Postoperative sublingual microcirculatory derangement following esophagectomy is prevented with dobutamine. Clinical Hemorheology and Microcirculation, 48(4), 275–283.

153. Lima A, Bakker J. Near-infrared spectroscopy for monitoring peripheral tissue perfusion in critically ill patients. Rev Bras Ter Intensiva 2011;23(3):341-351

2012 154. Bezemer, R., Bartels, S. A., Bakker, J., & Ince, C. Clinical review: Clinical imaging of the sublingual

microcirculation in the critically ill - where do we stand? Critical Care 2012;6(3):224. 155. de Groot, Y. J., Lingsma, H. F., Bakker, J., Gommers, D. A., Steyerberg, E., & Kompanje, E. J. O. (2012).

External validation of a prognostic model predicting time of death after withdrawal of life support in neurocritical patients. Crit Care Med 2012;40(1):233–238.

156. de Mul, M., Alons, P., van der Velde, P., Konings, I., Bakker, J., & Hazelzet, J. Development of a clinical data warehouse from an intensive care clinical information system. Comput Meth Prog Biomed 2012;105(1):22–30.

157. Sprung, C. L., Artigas, A., Kesecioglu, J., Pezzi, A., Wiis, J., Pirracchio, R., Baras, M., Edbrooke, D. L., et al.. The Eldicus prospective, observational study of triage decision making in European intensive care units. Part II: Intensive care benefit for the elderly. Crit Care Med 2012;40:132-138

158. Sprung, C. L., Baras, M., Iapichino, G., Kesecioglu, J., Lippert, A., Hargreaves, C., Pezzi, A., Pirrachio, R., et al. The Eldicus prospective, observational study of triage decision making in European intensive care units: Part I-European Intensive Care Admission Triage Scores (EICATS). Crit Care Med 2012;40:125-131

159. Tan, S. S., Bakker, J., Hoogendoorn, M. E., Kapila, A., Martin, J., Pezzi, A., Pittoni, G., et al. Direct cost analysis of intensive care unit stay in four European countries: applying a standardized costing methodology. Value Health 2012;15(1):81–86.

160. van Genderen, M. E., Lima, A., Akkerhuis, M., Bakker, J., & van Bommel, J. Persistent peripheral and microcirculatory perfusion alterations after out-of-hospital cardiac arrest are associated with poor survival. Crit Care Med 2012;40(8),2287–2294.

161. Vellinga, N. A. R., Boerma, E. C., Koopmans, M., Donati, A., Dubin, A., Shapiro, N. I., Pearse, R. M., et al. Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients. Crit Care Res Pract 2012;121752.

162. Verkade, M. A., Epker, J. L., Nieuwenhoff, M. D., Bakker, J., & Kompanje, E. J. O. Withdrawal of life-sustaining treatment in a mixed intensive care unit: most common in patients with catastropic brain injury. Neurocritical Care 2012;6(1):130–135.

163. Lima A, Van Genderen ME, Klijn E, Bakker J, Van Bommel J. Peripheral vasoconstriction influences thenar oxygen saturation as measured by near-infrared spectroscopy. Intensive Care Med 2012;38(4):606-611

164. Meynaar, I. A., Van Den Boogaard, M., Tangkau, P. L., Dawson, L., Sleeswijk Visser, S., & Bakker, J. Long-term survival after ICU treatment. Minerva Anestesiologica, 2012:78(12), 1324–1332.

165. Vincent, J.-L., Ince, C., & Bakker, J. Clinical review: Circulatory shock - an update: a tribute to Professor Max Harry Weil. Critical Care 2012;16(6), 239.

166. de Geus, H. R. H., Betjes, M. G., & Bakker, J. (2012). Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. Clinical Kidney Journal, 5(2), 102–108.

2013 167. Van Genderen ME, Bartels SA, Lima A, Bezemer R, Ince C, Bakker J, Van Bommel J. Peripheral perfusion

index as an early predictor for central hypovolemia in awake healthy volunteers. Anesthesia Analgesia 2013;116(2):351-356

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168. Bronkhorst MWGA, Boyé NDA, Lomax MAZ, et al. Single-nucleotide polymorphisms in the Toll-like receptor pathway increase susceptibility to infections in severely injured trauma patients. J Trauma Acute Care Surg 2013;74(3):862–70.

169. Klijn E, Hulscher HC, Balvers RK, et al. Laser speckle imaging identification of increases in cortical microcirculatory blood flow induced by motor activity during awake craniotomy. J Neurosurg 2013;118:280-286

170. Bakker, J. Memorable patients: I'll be dead on Friday. Intensive Care Med 2013;39:962 171. Genderen ME van, Lima A, Bakker J, Bommel J van. Peripheral circulation in critically ill patients: non-invasive

methods for the assessment of the peripheral perfusion. Ned Tijdschr Geneeskunde 2013: 157(9), A5338 172. Bakker, J., Nijsten, M. W. & Jansen, T. C. Clinical use of lactate monitoring in critically ill patients. Ann

Intensive Care 2013,12 173. Genderen, M. E.van, Bartels, S. A., Lima, A., Bezemer, R., Ince, C., Bakker, J., & van Bommel, J. (2013).

Peripheral perfusion index as an early predictor for central hypovolemia in awake healthy volunteers. Anesthesia and Analgesia, 2013;16(2), 351–356

174. Houwelingen, M. J van., Merkus, D., Hofland, J., Bakker, J., Tenbrinck, R., Lintel Hekkert, Te, M., Dijk G van, Hoeks APG, Duncker DJ. A novel approach to assess hemorrhagic shock severity using the arterially determined left ventricular isovolumic contraction period. American Journal of Physiology. Heart and Circulatory Physiology, 2013;305(12), H1790–7

175. Helmi M, Lima A, Gommers D, Bommel van J, Bakker J. Inflatable external leg compression prevents orthostatic hypotension in a patient with a traumatic cervical spinal cord injury. Future Cardiology 2013;9(5):645-648

176. Bikker IG, Blankman P, Specht P, Bakker J, Gommers D. Global and regional parameters to visualize the ‘best’ PEEP during a PEEP trial in a porcine model with and without acute lung injury. Minerva Anestesiologica 2013;79(9):983-92

177. van Genderen, M. E., Klijn, E., Lima, A., de Jonge, J., Sleeswijk Visser, S., Voorbeijtel, J., et al. Microvascular perfusion as a target for fluid resuscitation in experimental circulatory shock. Critical Care Medicine, 2014;42(2), e96–e105.

178. Citerio, G., Bakker, J., Bassetti, M., Benoit, D., Cecconi, M., Curtis, J. R., et al. Year in review in Intensive Care Medicine 2013: I. Acute kidney injury, ultrasound, hemodynamics, cardiac arrest, transfusion, neurocritical care, and nutrition. Intensive Care Medicine, 2014;40(2), 147–159.

179. Citerio, G., Bakker, J., Bassetti, M., Benoit, D., Cecconi, M., Curtis, J. R., et al. (2014). Year in review in Intensive Care Medicine 2013: I. Acute kidney injury, ultrasound, hemodynamics, cardiac arrest, transfusion, neurocritical care, and nutrition. Intensive Care Medicine, 40(2), 147–159.

2014 180. Lima, A., & Bakker, J. Clinical monitoring of peripheral perfusion: there is more to learn. Critical Care

2014;18(1):113. 181. Azoulay, E., Citerio, G., Bakker, J., Bassetti, M., Benoit, D., Cecconi, M., et al. Year in review in Intensive Care

Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients. Intensive Care Medicine, 2014;40(3), 305–319

182. Timsit, J.-F., Citerio, G., Bakker, J., Bassetti, M., Benoit, D., Cecconi, M., et al. (2014). Year in review in Intensive Care Medicine 2013: III. Sepsis, infections, respiratory diseases, pediatrics. Intensive Care Medicine, 1–13

183. G Citerio, G et al, Year in review in Intensive Care Medicine 2013: I. Acute kidney injury, ultrasound, hemodynamics, cardiac arrest, transfusion, neurocritical care, and nutrition. Intensive Care Medicine, 2014. 40(2): p. 147-159.

184. Almac E, Bezemer R, Kandil A, Aksu U, Milstein DMJ, Bakker J, Demirci-Tansel C, Ince C. Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats. Intensive Care Medicine Experimental 2014;2;3-9

185. MMC van Mol Margo MC, EC Bakker, MD Nijkamp, EJO Kompanje, J Bakker, L Verharen. Relatives' perspectives on the quality of care in an Intensive Care Unit: The theoretical concept of a new tool. Patient Education and Counseling, 2014. 95(3): p. 406-413.

186. EJO Kompanje, JL Epker, J Bakker. Hastening death due to administration of sedatives and opioids after withdrawal of life-sustaining measures: even in the absence of discomfort? J Crit Care 2014;29(3), 455–456.

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187. Meiracker A van den, Berg B van den, Herder W de, Bakker J. Extreme blood pressure oscillations in a patient with a MEN-2a syndrome. J Clin Endocrin Metab 2014;99(3):701-702

188. A Lima, ME van Genderen, J van Bommel, E Klijn, T Jansen, J Bakker. Nitroglycerin reverts clinical manifestations of poor peripheral perfusion in patients with circulatory shock. Crit Care, 2014. 18(3): p. R126.

189. Michel E van Genderen, Jorden Paauwe, Jeroen de Jonge, Ralf JP van der Valk, Alexandre Lima, Jan Bakker and Jasper van Bommel. Clinical assessment of peripheral perfusion to predict postoperative complications after major abdominal surgery early: a prospective observational study in adults. Critical Care. 2014;18(3), R114.

190. L Silvestri,N Taylor,HKF van Saene, J Bakker. Colistin, SDD and resistance: nihil novi sub sole. Intensive Care Medicine, 2014. 40(7): p. 1065.

191. Berlin DA, Bakker J. Understanding Venous Return. Intensive Care Med 2014;40(10):1564-1566 192. Glenn Hernandez, Cecilia Luengo, Alejandro Bruhn, Eduardo Kattan, Gilberto Friedman, Gustavo A Ospina-

Tascon, Andrea Fuentealba, Ricardo Castro, Tomas Regueira, Carlos Romero, Can Ince and Jan Bakker. When to stop septic shock resuscitation clues from a dynamic perfusion monitoring. Annals of Intensive Care, 2014. 4: p. 30.

193. van Mol MMC, Bakker EC, Nijkamp MD, Kompanje EJO, Bakker J, Verharen L. Relatives' perspectives on the quality of care in an Intensive Care Unit: The theoretical concept of a new tool. Patient Education and Counseling, 2014. 95(3): p. 406-413

194. Ista E, Trogrlic Z, Bakker J, Osse R, van Achterberg T, van der Jagt M. Improvement of care for ICU patients with delirium by early screening and treatment: study protocol of iDECePTIvE study. Journal Implement Sci 2014;9(1):143

195. Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, Jaeschke R, Mebazaa A, Pinsky MR, Teboul JL, Vincent JL, Rhodes A. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med 2014;40(12):1795-1815

196. Wan-Jie Gu, Fei Wang, Lu Tnag, Jan Bakker, Jing-Chen Liu Colistin for the treatment of ventilator-assiciated pneumonia caused by multidrug-resistant Gram-negative bacteria: a systematic review and meta-analysis. Int J Antimicrob Agents 2014;44(6):477-485

197. Gu W-J, Fei Wang F, Bakker J, Tang L, Liu J-C. The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials. Crit Care 2014;18(5):570

2015 198. NA Vellinga et al, International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients. Crit Care

Med, 2015;43(1):48-56 199. Bakker J, Perner A, Timsit J-F. Editorial: Evaluation of the 7.5 years of Surviving Sepsis Campaign Guidelines.

Intensive Care Med 2015;41(1):151-153 200. Prin M, Bakker J, Wagener G. Hepatosplanchnic circulation in sepsis. World J Gastroenterol.

2015;21:2582-2592 201. Bakker J. Lost in translation: On lactate, hypotension, sepsis induced tissue-hypoperfusion, quantitative

resuscitation and Surviving Sepsis Campaign bundles. Crit Care Med 2015;43:705-706 202. Reis Miranda D, Van Thiel R, Brodie D, Bakker J. Right ventricular unloading after initiation of veno-venous

extra-corporeal membrane oxygenation. Am J Respir Crit Care Med 2015;191:346-348 203. Van Genderen ME, Engels N, Ralf J. P. Van der Valk RJP, Lima A, Klijn E, Bakker J, Van Bommel J. Early

peripheral perfusion-guided fluid therapy in patients with septic shock. Am J Respir Crit Care Med 2015;191:477-480

204. Z Trogrlic, M van der Jagt, J Bakker, MC Balas, EW Ely, PHJ van der Voort, E Ista. A systematic review of implementation strategies for assessment, prevention, and management of ICU delirium and their effect on clinical outcome. Crit Care 2015 ;19(1):157

205. HT Speksnijder, Z Trogrlić, J Bakker, D dos Reis Mirands. Sterile endotracheal suctioning: effect on exogenous sputum colonization in mechanically ventilated ICU patients with decontaminated digestive tract. Intensive Care Med 2015;41(8):1500-1501

206. J Hofland, J Bakker, RA Feelders. What’s new on the HPA-axis? Intensive Care Medicine 2015;41(8):1477-1479

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207. E Klijn, ABJ Groeneveld, ME van Genderen, M Betjes, J Bakker, J van Bommel. Peripheral Perfusion Index Predicts Hypotension during Fluid Withdrawal by Continuous Veno-Venous Hemofiltration in Critically Ill Patients. Blood Purif 2015;40(1):92-98.

208. M van Mol, EJO Kompanje, J Bakker, MD Nijkamp. The Prevalence of Compassion Fatigue and Burnout among Healthcare Professionals in an Intensive Care Units: A systematic review. Plos One 2015;10(8);e0136955

209. Gu WJ, Zhang Z, Bakker J. Early lactate clearance-guided therapy in patients with sepsis: a meta-analysis with trial sequential analysis of randomized controlled trials. Intensive Care Med 2015;41: 1862-1863

210. Weigel JD, Hunfeld NG, Koch BC, Egal M, Bakker J, van Schaik RH, van Gelder T. Gain-of-function single nucleotide variants of the CYP2C19 gene (CYP2C19*17) can identify subtherapeutic voriconazole concentrations in critically ill patients: a case series. Intensive Care Med 2015;41: 2013-2014

211. Kompanje EJ, Bakker J, The brain is not dead when the cortex is dead. Crit Care Med 2015;43: e208 212. Tapia P, Soto D, Bruhn A, Alegria L, Jarufe N, Luengo C, Kattan E, Regueira T, Meissner A, Menchaca R,

Vives MI, Echeverria N, Ospina-Tascon G, Bakker J, Hernandez G, (2015) Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care 2015;19: 188

213. Berlin DA, Bakker J. Starling curves and central venous pressure. Crit Care 2015;19: 55 214. Lima A, Bakker J. Clinical assessment of peripheral circulation. Curr Opin Crit Care 2015;21: 226-231 215. Klijn E, van Velzen MH, Lima AP, Bakker J, van Bommel J, Groeneveld AB. Tissue perfusion and oxygenation

to monitor fluid responsiveness in critically ill, septic patients after initial resuscitation: a prospective observational study J Clin Monit Comput. 2015;29(6):707-712

216. Wagener G, Bakker J. Vasopressin in cirrhosis and sepsis: Physiology and clinical implications. Minerva Anesthesiol 2015;81(12):1377-1383

217. Epker JL, Bakker J, Lingsma HF, Kompanje EJ. An Observational Study on a Protocol for Withdrawal of Life-Sustaining Measures on Two Non-Academic Intensive Care Units in The Netherlands: Few Signs of Distress, No Suffering? J Pain Symptom Manage 2015;50(5):676-684

218. E Klijn, S Niehof, ABJ Groeneveld, A Lima, J Bakker, J van Bommel. Postural change in volunteers: Sympathetic tone determines microvascular response to cardiac preload and output increases. Clin Auton Res 2015:25(5):347-354

2016 219. Torres A, Bassetti M, Bakker J, Hospitalized patients at risk of dying: an Intensive Care Medicine call for

papers. Intensive Care Med 2016;42(1): 1-2 220. Donkelaar van KCE, Dijkland SA, Bergh van den WM, Bakker J, Dippel DWJ, Nijsten MWN, Jagt van der M.

Early circulating lactate and glucose levels after aneurysmal subarachnoid hemorrhage correlate with poor outcome and delayed cerebral ischemia: a two-center cohort study. Crit Care Med 2016;

221. Bakker J, De Backer D, Hernandez G. Lactate-guided resuscitation saves lives: we are not sure. Intensive Care Med 2016;42(3):472-474

222. Ait-Oufella H, Bakker J. Understanding clinical signs of poor perfusion during septic shock. Intensive Care Med 2016;42(12):2070-2072

223. Z Trogrlic, E Ista, J Bakker, M vd Jagt. Attitudes, knowledge an practices concerning delirium: a survey among ICU professionals. Nursing Crit Care 2016 (in press)

224. Van Mol MMC, Boeter GW, Verharen L, Kompanje EJO, Bakker J, Nijkamp MD. Patient- and family-centered care in the intensive care unit; a challenge in the daily practice of the healthcare professionals. J Clin Nursing 2016 (in press)

225. Van Mol MMC, Brackel M, Kompanje EJO, Gijsbers L, Nijkamp M, Girbes ARJ, Bakker J. Joined forces in person-centered care in the Intensive Care Unit: A case report from the Netherlands. J Compassionate Health Care 2016 (in press)

226. Meynaar IA, Van Saase JLCM, Feberwee T, Aerts TM, Bakker J, Thijsse W. Burnout among Dutch intensivists – a nationwide surey. Neth J Crit Care 2016 (in press)

227. Bugedo G, Egal M, Bakker J. Prolonged mechanical ventilation and chronic critical illness. J Thorac Dis 2016; 8(5):751-753

228. Bakker J, Takala J. Vasopressor therapy: not like antibiotics! Intensive Care Med 2016;42(7):1195-1196 229. Weigel J, Bakker J. Fatal calyceal-venous fistula. Intensive Care Med 2016;42(11):2070-2072 230. Bakker J. Focus on Acute Circulatory Failure. Intensive Care Med 2016;42(12):1862-1864

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231. Hernandez G, Tapia P, Alegria L, et al. Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock. Crit Care 2016;20(1):234.

232. Dzierba AL, Brodie D, Muir J, Wasson L, Colabraro M, Gannon W, Connoly K, Moitra V, Bakker J. Ketamine in sedation management in patients receiving extracorporeal membrane oxygenation. Intensive Care Med 2016;42(11):1822-1823

233. Brunauer A, Koköfer A, Bataar O, Gradwohl-Matis I, Dankl D, Bakker J, Dünser MW. Changes in peripheral perfusion relate to organ perfusion in early septic shock: a pilot study. J Crit Care 2016;35:105-109

234. M van Mol, M Brackel, EJO Kompanje, L Gijsbers, M Nijkamp, ARJ Girbes, J Bakker. Joined forces in person-centered care in the intensive care unit: A case report from the Netherlands. J Compassionate Health Care 2016;3:5

235. Wijnia JW, Oudman E, van Gool WA, et al. Severe Infections are Common in Thiamine Deficiency and May be Related to Cognitive Outcomes: A Cohort Study of 68 Patients with Wernicke-Korsakoff Syndrome. Psychosomatics 2016;57(6):624-633

236. Bakker J. Lactate and hemodynamic coherence in acute circulatory failure. Best Practice Research Clinical Anaesthesiology. 2016;30(4):523-530

2017 237. Goligher EC, Ely EW, Sulmasy DP, Bakker J, Raphael J, Volandes AE, Patel BM, Payne K, Hosie A, Churchill

L, White DB, Downar J. Physician-Assisted Suidice and Euthanasia in the Intensive Care Unit: A dialogue on core ethical issues. Crit Care Med 2017;45(2):149-155

238. Alegria L, Vera M, Dreyse J, Castro R, Carpio D, Henriquez C, Gajardo D, Bravo S, Araneda F, Kattan E, Torres P, Ospina-Tascon G, Teboul JL, Bakker J, Hernandez G. A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study. Ann Intensive Care 2017;7(1):29

239. Van Mol MMC, Boeter TGW, Verharen L, Kompanje EJO, Bakker J, Nijkamp M. Patient- and family-centered care in the intensive care unit: a challenge in the daily practice of healthcare professionals. J Clin Nursing 2017;26:19.20

240. Pieterse JM, Dos Reis Miranda D, Bakker J. Increasing intensity of selective digestive decontamination (SDD) dosing does not result in improved clinical outcomes. Minerva Anesth 2017;83(5):529-530

241. Bakker J. Lactate is THE target for early resuscitation in sepsis. Rev Bras Ter Intensiva 2017;29(2):124-127 242. Estenssoro E, Alegria L, Murias G, Friedman G, Castro R, Azevedo L, Nin N, Loudet C, Bruhn A, Jibaja M,

Ospina-Tascon G, Rios F, Machado FR, Cavalcanti AB, Dubin A, Hurtado FJ, Briva A, Romero C, Bugedo G, Bakker J, Cecconi M, Hernandez G. Organizational issues, structure and processes of care in 254 ICU’s in Latin America: a survey from the Latin America Care Network (LIVEN). Crit Care Med 2017;45(8):1325-1336

243. Kiyatkin ME, Bakker J. Lactate and microcirculation as suitable targets for hemodynamic optimization in resuscitation of circulatory shock. Curr Opin Crit Care 2017;23(4):348-354

244. Brodie D, Curtis, JR, Vincent JL, Bakker J, Brown CE, Creteur J, Papazian L, Sladen RN, Ranieri, VM. Treatment limitations in the era of ECMO. Lancet Resp Dis 2017;5(10):769-770

245. Lara B, Enberg L, Ortega M, et al. Capillary refill time during fluid resuscitation in patients with sepsis-related hyperlactatemia at the emergency department is related to mortality. PLOS One 2017;12(11):e0188548

2018 246. Vos JJ, Kalmar AF, Hendriks HGD, Bakker J, Scheeren TWL. The effect of fluid resuscitation on the effective

circulating volume in patients undergoing liver surgery. J Clin Monitor Comp 2018;32:73-80 247. Vink EE, Bakker J. Practital use of lactate in the intensive care. J Intensive Care Med 2018 (in press) 248. Van Mol MMC, Nijkamp MD, Bakker J, Schaufeli W, Kompanje EJO. Counterbalancing to work-related

stress: work engagement among intensive care professionals. Australian Crit Care 2018 (in press) 249. Vergouw L, Egal M, Dippel D, Lingsma H, Vergouwen M, Magnus R, Willems P, Oldendbeuving A, Bakker J,

van der Jagt M. High early fluid input after aneurysmal subarachnoid haemorrhage: combined report of association with delayed cerebral ischaemia and feasibility of cardiac output-guided fluid resuscitation. J Intensive Care 2018 (in press)

250. Ince C, Boerma EC, Cecconi M, De Backer D, Shapiro N, Duranteau J, Pinsky MR, Artigas A, Teboul JL, Reis I, Aldecoa C, Hutchings SD, Donati A, Maggiorini M, Taccone FS, Hernandez G, Payen D, Tibboel D, Martin D, Zarbock A, Monnet X, Dubin A, Bakker J, Vincent JL, Scheeren TWL. Second consensus on the

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monitoring of sublingual microcirculation in critically ill patients. Task force of the European Society of Intensive Care Medicine. Intensive Care Medicine 2018 (in press)

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BOOKS Chapters 1. J.Bakker. Optimalisering van zuurstoftransport en zuurstofconsumptie in acuut circulatoir falen (shock). In:

Intensive Care Capita Selecta 1991:207-221. Edt. B. de Lange, J.H. Rommes, J.H. Zwaveling. Venticare Utrecht.

2. J. Bakker. Acuut circulatoir falen en multiple organ failure: van behandeling naar prevnetie. In: Intensive Care Capita Selecta 1992:331-342. Edt. J. Bakker, B. de Lange, J.H. Rommes. Venticare Utrecht.

3. J.Bakker. Oxygen transport and consumption in patients with septic shock. In: Topicos de Terapia Intensiva. Editor: V.N. Felix. 1992; 47-51. Sao Paulo, Brasil.

4. J. Bakker. Optimalisering van zuurstoftransport en zuurstofconsumptie bij patienten met acuut circulatoir falen (shock). In: Intensive Care Capita Selecta 1993:337-353. Edt. J. Bakker, B. de Lange, J.H. Rommes. Venticare Utrecht.

5. J-L.Vincent, J.Bakker, P.Silance. Relationship between oxygen demand and oxygen supply in severe sepsis. In: Schlag G, Redl H, eds. Pathophysiology of shock, sepsis and organ failure. Berlin: Springer Verlag, 1993:908-914.

6. J.Bakker. Principles of oxygen transport and consumption. In: J.Bakker (Edt.). Tissue oxygen delivery in the critically ill. Ibero, Houten (Nl) 1995.

7. J.Bakker. Monitoring of blood lactate levels in critically ill patients. In: J.Bakker (Edt.). Tissue oxygen delivery in the critically ill. Ibero, Houten (Nl) 1995.

8. J.Bakker. Physiology of tissue oxygen delivery. In: Update in Intensive Care and Emergency Medicine. Applied cardiovascular physiology. 1997;28:64-75. Springer, Berlin.

9. J.Bakker. Volumetherapie. In: Compendium Intensive Care. Elsevier , Maarssen 2000. 515-520 10. J. Bakker. Point-of-Care lactate to predict patient outcomes. In: Principles & Practice of Point-of-Care Testing.

G.J. Kost editor. Lippincott Williams & Wilkins Philadelphia Part VI Economics, Outcomes and optimization 11. J.H.M Hofuis, PE Spronk, J Bakker. Kwaliteit van leven na ernstige ziekte. In: Intensive Care Capita Selecta

2004. Editor: J.Bakker, B. de Lange, JH Rommes. Venti Care Utrecht 2004 12. J. Bakker, A Pinto de Lima. Monitorização da perfusão tecidual. In: Monitorização em UTI. AR Neto, C Leite

Mendes, EA de Carvalho Rezende, F Suparregui Dias editors. Revinter Tijuca, Brasil. 2004;89-101 13. T.Jansen, R.Woodward, J.Bakker. Veneuze oxymetrie en lactaat: wanneer is het genoeg? In: Intensive Care

Capita Selecta 2006. Editor: J.Bakker, B. de Lange, JH Rommes. Venti Care Utrecht 2006.41-49 14. J.H.M. Hofhuis, J.Bakker, J.H. Rommes, P.E. Spronk. Kwaliteit van leven voor en na ontslag intensive care. In:

Intensive Care Capita Selecta 2006. Editor: J.Bakker, B. de Lange, JH Rommes. Venti Care Utrecht 2006.245-250

15. A Lima, J Bakker. Noninvasive monitoring of peripheral circulation. In: Applied physiology in intensive care. Editors MR Pinsky, L Brochard, J Mancebo. Springer Berlin 2006;31-142

16. J Bakker and P. Verboom. Technology Asessment. In: Update in intensive care and emergency medicine 43: Intensive Care Medicine in 10 years. 2006 Springer Berlin. 2006;87-99

17. B van der Hoven, D Gommers, J Bakker. Critical illness and the hepatic microcirculation: A review. In: Yearbook of intensive care and emergency medicine 2007 Springer Berlin. 2007;643-650

18. J Bakker, TC Jansen. Lactate levels: A clinical guide at the bedside. In: Update in intensive care and emergency medicine 2012 Springer Berlin. 2012

19. M. van Genderen, A. Lima, J. Bakker. Peripheral Monitoring in critically ill patients. In: Update in intensive care and emergency medicine 2013 Springer Berlin. 263-276

20. M de Vos and J Bakker. I’m going to make a decision but you as a family need to help me [Ik ga een besluit nemen, maar u als familie moet me helpen]. In: When shared decision making is not obvious [Wanneer samen beslissen niet vanzelf spreekt]. Center for Ethics and Healthcare 2014;43-46

21. J Bakker and S Schutte. The clinical patient at risk [De bedreigde klinische patient]]. In: Textbook of acute medicine [Leerboek acute geneeskunde]. Reed Business Education Amsterdam. Edt. A van Vugt et al. 2014;87-96

22. J. Bakker. Controversies: ScvO2 vs. lactate clearance to guide resuscitation in septic shock? Critical Care Medicine. McGraw-Hill. Edt. J Oropello, V Kvetan and S Pastores.2017

23. T.C. Jansen, J Bakker. Lactate. In: Oxford Textbook of Critical Care 2nd edition. 2017. 24. EJO Kompanje, J Bakker. Beyond semantics: Disproportionate use of intensive care resources or medical

futility. In: Update in intensive care and emergency medicine 2017 Springer Berlin. 2017

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25. V Mukherjee, SB Brosnahan, J Bakker . How to used fluid responsiveness in sepsis. In: Update in intensive care and emergency medicine 2017 Springer Berlin. 2017

26. MMC van Mol, EJO Kompanje, J Bakker. Reflections on work related stress among intensive care professionals: a historical perspective. In: Update in intensive care and emergency medicine 2017 Springer Berlin. 2017

27. G Hernandez, MW Nijsten, J Bakker. Lactate monitoring in sepsis. In: Monitoring tissue perfusion in shock: from physiology to the bedside. Springer 2018

28. D Berlin, V Moitra, J Bakker. Guyton physiology at the bedside. In: Monitoring tissue perfusion in shock: from physiology to the bedside. Springer 2018

29. G Hernandez, L Rosenthal, J Bakker. Holistic view on monitoring and shock. In: Monitoring tissue perfusion in shock: from physiology to the bedside. Springer 2018

30. R Castro, G Hernandez, J Bakker. Oxygen transport and tissue utilization. In: Monitoring tissue perfusion in shock: from physiology to the bedside. Springer 2018

31. R Castro, G Hernandez, J Bakker. Oxygen transport and tissue utilization. In: Monitoring tissue perfusion in shock: from physiology to the bedside. Springer 2018

32. LPB Meijs, AFGH Bindels, J Bakker, MR Pinsky. Cardiac function (cardiac output and its determinants). In: Monitoring tissue perfusion in shock: from physiology to the bedside. Springer 2018

EDITOR BOOKS 1. Tissue oxygen delivery in the critically ill. Edt. J. Bakker. Ibero, Houten (Nl) 1995. 2. Intensive Care Capita Selecta 1993. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht. 3. Intensive Care Capita Selecta 1994. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht. 4. Intensive Care Capita Selecta 1995. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht. 5. Intensive Care Capita Selecta 1996. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht. 6. Intensive Care Capita Selecta 1997. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht. 7. Intensive Care Capita Selecta 1998. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht. 8. Intensive Care Capita Selecta 1999. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht. 9. Intensive Care Capita Selecta 2000. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht. 10. Intensive Care Capita Selecta 2001. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht 11. Intensive Care Capita Selecta 2002. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht 12. Intensive Care Capita Selecta 2003. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht 13. Intensive Care Capita Selecta 2004. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht 14. Intensive Care Capita Selecta 2005. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht 15. Intensive Care Capita Selecta 2006. Edt. J Bakker, B de Lange, JH Rommes. Venti Care, Utrecht 16. Intensive Care Capita Selecta 2007. Edt. J Bakker, MHWA van den Boogaard, B de Lange, JH Rommes, PHJ

van der Voort. Venti Care Utrecht 17. Intensive Care Capita Selecta 2008. Edt. J.Bakker, MHWA van den Boogaard, B. de Lange, PHJ. van der

Voort. Venti Care Utrecht 18. Intensive Care Capita Selecta 2009. Edt. J.Bakker, MHWA van den Boogaard, B. de Lange, PHJ. van der

Voort. Venti Care Utrecht 19. Intensive Care Capita Selecta 2010. Edt. J.Bakker, MHWA van den Boogaard, B. de Lange, PHJ. van der

Voort. Venti Care Utrecht SPECIAL EDITION EDITOR JOURNALS 1. Current Opinion in Critical Care 2009: Special issue on Health Care Outcomes 2. Critical Care 2009: Special issue on Near Infrared Spectroscopy 3. Current Opinion in Critical Care 2012: Special issue on Cardiopulmonary monitoring

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ABSTRACTS (INCOMPLETE) 1. J.Bakker, J-L.Vincent. Dobutamine and norepinephrine treatment in relation to oxygen delivery and

consumption in endotoxin shock. Anesthesiology 1990;73:A313 2. J.Bakker, J-L.Vincent. Dobutamine and norepinephrine administration in a dog model of endotoxic shock.

Circ Shock 1991;34:110 3. H. Zhang, J.Bakker, J-L.Vincent. Effects of dobutamine on oxygen extraction in a dog model of cardiac

tamponade. Circ Shock 1991;34:114 4. P. van der Linden, J.Bakker, D.Schmartz, J-L.Vincent. Arteriovenous PCO2 differences reflects tissue

hypoxia during hemorrhagic shock in dogs. Circ Shock 1991;34:87 5. Ph.vander Linden, E Gilbart, P Pâques, J Bakker, J-L Vincent. Veno-arterial gradienst for PCO2 and pH

reflect tissue hypoxia during hemorrhagic shock in dogs. Anesthesiology 1991;75:A236 6. J.Bakker, M. Leon, M. Coffernils, P. Gris, R.J. Kahn, J-L. Vincent. Relatie tussen lactaatconcentratie en

orgaandysfunctie bij patienten met een septische shock. Ned Tijdschr Geneeskd 1992; 136:2394 7. J.Bakker, H.Zhang, B.S.van Asbeck, J-L.Vincent. N-Acetylcysteine improves tissue oxygenation in a dog

model of endotoxin shock. Medicina Intensiva 1993; 17:S30. 8. J.Bakker and J-L.Vincent. Dobutamine and norepinephrine administration in septic shock patients. Crit

Care Med 1994;22:A110 9. J Bakker, JH Rommes. Worst APACHE II score vs time-fixed APACHE II score in critically ill patients.

Intensive Care Med 1996;22:S279 10. J Bakker, JH Rommes. Costs of ICU treatment in a general Dutch Intensive Care Unit. Intensive Care Med

1996;22:S302 11. PB de Munck, JH Rommes, ThGMA van Deursen, J Bakker. Cardiovascular variability in critically ill patients

by power spectral analysis. Intensive Care Med 1996;22:S361 12. J.Hofhuis, JH Rommes, J. Bakker. Patients recollection in intensive care unit experience. Intensive Care

Med 1996;22:S295 13. J.Bakker, B.Lodato, J.Donaldson, R.Grover, K.Guntapalli, J.Takala. Multicenter, placebo-controlled

double-blind trial of the nitric oxide synthase inhibitor 546C88 in patients with septic shock: acute effects on the pulmonary circulation. Am Jounal Respir Crit Care Med 1997;155:A702

14. R.F.Lodato, J.Bakker, R.Balk, S.Grossman. Multicentre, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88 in patients with septic shock: effect in those with pulmonary hypertension. Intensive Care Med 1997;23:S55

15. S.E.Geerlings, J.H.Rommes, D.W.van Toorn, J.Bakker. Acute folate deficiency following high volume continuous venovenous hemofiltration. Neth Jounal Med 1997;50:A41

16. B.J.Hartman, J.H.Rommes, J.Bakker. Thermodilution versus double indicator techniques to assess preload in critically ill patients. Intensive Care Med 1997;23:S82

17. B.J.Hartman, J.H.Rommes, J.Bakker. Comparison of pulmonary and femoral artery thermo-dilution cardiac indices in critically ill patients. Intensive Care Med 1997;23:S89

18. S.J.M.Schieveld, J.Bakker. Prehospital blood lactate levels in emergency medicine. Intensive Care Med 1997;23:S183

19. J.Bakker, J.Weg, D.Zaccardelli, R.Grover, D.Watson. Multicenter placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88 in patients with septic shock: effects on cardiovascular function. Crit Care Med 1998;26:A63

20. J.Bakker, J.H.Rommes. Costs of severe sepsis in a multidisciplinary intensive care unit. Crit Care Med 1998;26:A131

21. R. Grover, J.Bakker, A. McLuckie, J.Andersson, J-R. LeGall. The nitric oxide synthase inhibitor 546C88 promotes the resolution of shock in patients with severe sepsis. Crit Care Med 1998;26:A29

22. D.Watson, J.Bakker, R.Beale, J.Donaldson, J.L.Vincent. A prospective randomized placebo controlled study of the nitric oxide synthase inhibitor 546C88 in human septic shock: effects on oxygen transport. Crit Care Med 1998;26:A63

23. W. Brinkert, J. Bakker. Lactate measurements in critically ill patients; evaluation of a pocket analyzer. Intensive Care Med 1998;24:S53

24. R. Grover, A. Lopez, J. Lorente, J. Steingrub, J. Bakker, S. Willatts, A. McLuckie, J. Takala. Multi-center, randomized, placebo-controlled, double blind study of the nitric oxide synthase inhibitor 546c88: Effect on survival in patients with septic shock. Crit Care Med 1999;27:A33

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25. J. Hofhuis, J. Hautvast, AJP Schrijvers, J. Bakker. Agreement between patient and proxy regarding the patient’s health status on admission to the ICU. Intensive Care Med 2000;26;S310

26. J. Bakker. Costs of Severe sepsis in a mixed intensive care unit. Intensive Care Med 2001; 27(13):S283 27. CPC de Jager, J. Bakker. Costs of organ failure in a mixed intenisve care unit in the Netherlands. Intensive

Care Med 2001; 27(13):S207 28. Van Gestel A, Bakker J, Veraart C, Van Hout B. The costs of severe sepsis; The Netherlands, 2000. Value

in Health 2002; 5(6): 561. 29. Van Gestel A, Bakker J, Veraart C, Van Hout B. Incidence of severe sepsis in the Netherlands; a point

prevalence survey. Value in Health 2002; 5(6): 576. 30. Hofhuis J, Bakker J. Health related quality of life in severe sepsis. Intensive Care Med 2002;S129 31. Karabinis A, Malbrain M, Bakker J et al. Remifentanil-based analgesia and sedation is well tolerated when

administered for up to 10 days in mechanically ventilated ICU patients. Crit Care 2004;8(suppl 1);P237 32. Lima A, Bakker J. The peripheral perfusion index in reactive hyperemia in critically ill patients. Crit Care

2004;8(suppl 1):P53 33. Hofhuis J, Bakker J, van Stel H, Schrijvers A, Rommes J, Spronk P. Changes in health-related quality of life

in severe sepsis. Crit Care 2005;9(Suppl 1):P241 34. Mik E, Bakker J. A method for improvement of data quality from OPS/SDF devices in visualization of the

microcirculation. Crit Care 2006;10(Suppl 1):P317 35. Zijnen M, Bakker J. Bedside teaching in intensive care: effect on attitudes and skills of fourth-year students.

Crit Care 2006;10(Suppl 1):P391 36. Hofhuis J, Hendrikse K, Stel van H, Schrijvers G, Rommes H, Bakker J. Quality of life before, during and

following intensive care treatment: a long term follow-up study. Crit Care 2006;10(Suppl 1):P427 37. Hoven van B, Veld In ‘t W, Mol W, Bakker J. Anti HSP-90 (Mycrograb), first experience with new

combination therapy in severe fungal infections. Intensive Care Med 2006;32(suppl 13): 38. Berg van den B, Bakker J. Effect of PEEP on experiratory time-constants in COPD. Intensive Care Med

2006;32(suppl 13): 39. Woodward R, Jansen TC, Mulder PG, Bakker J. Evaluation of serial lactate measurement related to SOFA

score. Intensive Care Med 2006;32(suppl 13): 40. Jansen TC, Mulder PG, Bakker J. Pathophysiology of hyperlactatemia determines prognostic

characteristics of lactate. Intensive Care Med 2006;32(suppl 13): 41. Vrakking AM, Kompanje EJO, Heide van der A, Bakker J. Symptom relief, sedation and termination of life in

a Dutch ICU: Nurses and physicians opinions. Intensive Care Med 2006;32(suppl 13): 42. Buise M, Gommers D, Tran K, Bakker J, Bommel van J. A multimodal anesthetic approach for

esophagectomy reduces postoperative pulmonary morbidity. Intensive Care Med 2006;32(suppl 13): 43. Bakker J, Mulder PG. Remifentanyl shortens duration of mechanical ventilation and ICU stay. Intensive

Care Med 2006;32(suppl 13): 44. Kesecioglu J, Bakker J, Edbrook D, Baras M et al. Ethics of refusing patients with greater than 85%

likelihood of death. Intensive Care Med 2006;32(suppl 13): 45. Sprung CL, Bakker J, Kesecioglu J, Edbrook D, Baras M et al. Triage admission and rejection variations in

European Intensive Care Units. Intensive Care Med 2006;32(suppl 13): 46. Sprung CL, Bakker J, Kesecioglu J, Edbrooke, D, Baras M et al. Triage decisions and bias against the

elderly in European Intensive Care Units. Intensive Care Med 2006;32(suppl 13): 47. B. van der Hoven, D. Gommers, F. Bonthuis, H. Tilanus, J. Bakker Hepatic microcirculation and tissue

oxygenation in sepsis and after hemihepatectomy in a small animal model. Inflamm.Res. 2007;56(Suppl.2):S303

48. I Bikker, D Reis Miranda, J van Bommel, J Bakker, D Gommers. Functional residual capacity measurement during mechanical ventilation in order to find the optimal positive end-expiratory pressure. Crit Care 2007;11(suppl 2): S84

49. J van Bommel, H Tilanus, J Bakker, D Gommers. Sublingual microcirculation is impaired on the first day postoperatively in patients undergoing gastric tube reconstruction. Crit Care 2007;11(suppl 2): S108

50. B Atasever, D Gommers, J Bakker. Conjunctival and sublingual microcirculation alterations in head trauma patients with increased intracranial pressure. Crit Care 2007;11(suppl 2): S143

51. M Al, L Hakkaart, S Tan, P Mulder, J Bakker. Remifentanil vs conventional sedation in The Netherlands: a pharmacoeconomic model analysis. Crit Care 2007;11(suppl 2): S170

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52. L Hakkaart, S Tan, C Bouwmans, M Al, P. Spronk, J Bakker. The costs of intensive care. Crit Care 2007;11(suppl 2): S193

53. P Spronk, J Hofhuis, H van Stel, J Rommes, A Schrijvers, J Bakker. Quality of life before intensive care unit admission is a strong predictor of survival. Crit Care 2007;11(suppl 2): P52

54. M Al, L Hakkaart, SS Tan, P Mulder, J Bakker. Influence of remifentanil on duration of mechanical ventilation, ICU length of stay and ICU costs. Eur J Anaesthesiol 2007;24(S39):149

55. M Zijnen-Suyker, VT Nguyen, J Bakker. Bedside-teaching in intensive care: the role of the icu nurse versus an intensivist as a teacher for medical students. Intensive Care Med, 2007;33 (Suppl.2): P0686

56. M Zijnen-Suyker, VT Nguyen, J Bakker. Bed-side teaching in Intensive Care: Attitudes and Perceptions of Fourth Year Medical Students regarding Critical Care Medicine Training. Crit Care Med 2007 Vol.35, N0.12 (Suppl): A 456

57. Atasever B, Gommers D, Bakker J. Conjunctival and sublingual microcirculation alterations in head trauma patients with increased intracranial pressure. Crit Care 2007; 11 (Suppl 2): S143

58. Bikker I, Reis Miranda D, van Bommel J, Bakker J, Gommers D. Functional residual capacity measurement during mechanical ventilation in order to find the optimal positive end-expiratory pressure. Crit Care 2007; 11 (Suppl 2): S84-S85

59. van Bommel J, Tilanus H, Bakker J, Gommers D. Sublingual microcirculation is impaired on the first day postoperatively in patients undergoing gastric tube reconstruction. Crit Care 2007; 11 (Suppl 2): S108

60. van der Hoven B, Gommers D, Bonthuis F, Tilanus H, Bakker J. Hepatic microcirculation and tissue oxygenation in sepsis and after hemihepatectomy in a small animal model. Inflamm Res 2007; 56(Suppl.2): S303

61. Jansen TC, Kompanje EJO, Druml C, Menon D, Wiedermann CJ, Bakker J. Deferred consent and early death: use the data? Intensive Care Med 2007; 33, supplement 2: S 202

62. Jansen TC, Kompanje EJO, van der Klooster JM. Bakker J. Importance of deferred consent in emergency research. Intensive Care Med 2007; 33, supplement 2: S 79

63. Jansen TC, Woodward R, Mulder PG, Bakker J, Evaluation of serial lactate measurements related to sofa score, Neth J Crit Care 2007

64. Jansen TC, Lima AP, Rommes JH, Snellen FTF, Mulder PG, Van Bommel J, Bakker J. Prognostic characteristics of hyperlactatemia: does etiology matter? Neth J Crit Care 2007

65. Lima A, Jansen T, Ince C, Bakker J. Noninvasive monitoring of peripheral perfusion with physical examination and the peripheral flow index correlates with dynamic near-infrared spectroscopy measurements in patients with septic shock. Critical Care 2008, 12(Suppl 2):P60

66. B. van der Hoven, T. Teerlink, S. de Jong, P.A.M. van Leeuwen, J. Bakker, D. Gommers. Arginine metabolism in a small animal model of sepsis and after hemihepatectomy. Critical Care 2009;13(suppl 1):S55(doi:10,1186/cc7297)

67. A Lima, M Alamyar, C Ince, J Bakker. Oxygen saturation determined from the mouth is an early indicator of central hypovolemia in humans. Crit Care 2010;14(suppl 1):S43

68. E Klijn, S Niehof, J Bakker, C Ince, J van Bommel. Effect of a preload challenge on peripheral perfusion in critically ill patients. Crit Care 2010;14(suppl 1):S44

69. A Knook, D Reis Miranda, J van Bommel, A Bogers, D Duncker, D Gommers, J Bakker. Validation of echocardiographic indices of right ventricular afterload: an experimental, open pericardium pig model. Crit Care 2010;14(suppl 1):S46

70. A Lima, J Weigel, E Hoorn, E Klijn, R de Jonge, N Morgenthaler, U Haagen, S Hofdom, J van Ochten, C Ince, J Bakker. Delayed increase in inflammation and thenar VO2 in marathon runners. Crit Care 2010;14(suppl 1):S52

71. A Veening, C Ince, J Bakker. Incidence of low tissue oxygen saturation in a mixed population of critically ill patients. Crit Care 2010;14(suppl 1):S52

72. I Bikker, C Preis, J Bakker, D Gommers. Electrical impedance tomography at two thoracic levels provides detailed information about ventilation distribution in the cranial to caudal direction. Crit Care 2010;14(suppl 1):S60

73. I Bikker, B vd Berg, P Specht, J Bakker, D Gommers. Transpulmonary pressure and ventilation distribution measured with EIT during a PEEP trial in porcine acute lung injury. Crit Care 2010;14(suppl 1):S62

74. CD van der Marel, H de Geus, J Bakker. Neutrophil gelatinase-associated lipocalin as an early indicator for postoperative renal failure. Crit Care 2010;14(suppl 1):S177

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75. WP Ridder, H de Geus, J Bakker. Neutrophil gelatinase-associated lipocalin as an early indicator for mortality in adult critically ill patients with acute kidney injury. Crit Care 2010;14(suppl 1):S177

76. SC Schuit, JJ van Koesveld, AJ Bogers, J Bakker, RJ van Thiel. Dexamethasone treatment during cardiac surgery and postoperative lactate levels. Crit Care 2010;14(suppl 1):S196

77. A Lima, M Van Genderen, E Klijn, S Bartels, J Van Bommel, J Bakker. Perfusion index as a predictor for central hypovolemia in humans. Critical Care 2011, 15(Suppl 1):P69

78. M Van Genderen, J Boszhuizen, A Pinto Lima, D Gommers, J Bakker, J Van Bommel. Dynamics of peripheral perfusion parameters in elective coronary artery bypass graft patients. Critical Care 2011, 15(Suppl 1):P77

79. E Klijn, M Van Genderen, M Betjes, J Bakker, J Van Bommel. Effects of ultrafiltration on systemic hemodynamics and microcirculatory perfusion in patients with end-stage kidney disease. Critical Care 2011, 15(Suppl 1):P111

80. M Terwiel, H De Geus, J Bakker, M Van der Jagt. Increased plasma neutrophil gelatinase-associated lipocalin levels in poor-grade aneurysmal subarachnoid hemorrhage at admission to the ICU. Critical Care 2011, 15(Suppl 1):P325

81. J Van den Bosch, J Van Bommel, J Bakker, D Gommers. Introduction of a remifentanil-based analgo-sedation protocol leads to a reduction of duration of mechanical ventilation and ICU stay in critically ill patients. Critical Care 2011, 15(Suppl 1):P361

82. A Veening, S Sleeswijk Visser, A Lima, J Calvache, J Bakker. Incidence of abnormal tissue oxygen saturation in critically ill patients. Crit Care Med 2011;39(12 suppl):A244

83. G Friedman, C Alan, A Meregalli, A Lima, J Bakker. Curve analysis of tissue oxygen desaturation after a venous occlusion test does not identify the central venous hemoglobin oxygen saturation. Crit Care 2012;16(S1):P257

84. A Lima, M van Genderen, J van Bommel, Bakker. Nitroglycerin dose-dependent improves peripheral perfusion in patietns with circulatory shock: results of a prospective cross-over study. Intensive Care Med 2012;38(1):S127

85. M E van Genderen, T Boerstra, A Lima, J Bakker, J van Bommel. Serial evaluation of peripheral perfusion to predict outcome in critically ill patients. Intensive Care Med 2012;38(1):S15

86. L Vergouw, D W Dippel, J Bakker, M van der Jagt. Association of fluid balance and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Intensive Care Med 2012;38(1):S111

87. M E van Genderen, J Paauwe, A Lima, J Bakker, J van Bommel. Peripheral perfusion alterations after major abdominal surgery are associated with postoperative complications. Intensive Care Med 2012;38(1):S126

88. E Klijn, H N van Velzen, A B J Groeneveld, A P Lima, J Bakker, J van Bommel. Tissue perfusion indicators predict and depend on systemic fluid responsiveness in critically ill septic patients with presumed hypovolemai. Intensive Care Med 2012;38(1):S199

89. A Lima, M van Genderen, T Boerstra, J van Bommel, J Bakker. Significance of an abnormally low or high resting StO2 values predicting high risk of mortality in critically ill patients. Intensive Care Med 2012;38(1):S211

90. Z Trogrlic, E Ista, A Slooter, J Bakker, M van der Jagt. Current practices in ICU delirium management: a prospective multicenter study in the Netherlands. Crit Care 2013;17(S1):P395

91. Z Trogrlic, M van der Jagt, P van der Voort, J Bakker, E Ista. Current perspectives, beliefs and practices concerning delirium in critically ill patients: a multicenter survey among Dutch healthcare professionals. Crit Care 2013;17(S1):P397

92. M Helmi, A Lima, D Gommers, J Bakker, J van Bommel. THE INFLATABLE EXTERNAL LEG COMPRESSION IMPROVES STROKE VOLUME AND PERIPHERAL PERFUSION DURING CENTRAL HYSPVOLEMIA IN HEALTHY VOLUNTEERS. INTENSIVE CARE MEDICINE 2013;39, S463-S464

93. Z Trogrlic, M Van der Jagt, J Bakker, MC Balas, EW Ely, PH Van den Voort, E Ista. Delirium screening, prevention and treatment in the ICU: a systematic review of implementation strategies. Critical Care 2014;18 (Suppl 1), P423

94. A Sommese, A Lima, J Van Bommel, J Bakker. Effects of central hypovolemia induced by tilt table on the Doppler-based renal resistive index in healthy volunteers. Critical Care 2014;18 (Suppl 1), P147

95. M Van Mol, E Kompanje, J Bakker, M Nijkamp. Compassion fatigue and burnout among healthcare professionals in the ICU. Critical Care 2014;18 (Suppl 1), P19

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96. B Bergmans, M Egal, J Van Bommel, J Bakker, M Van der Jagt. Effects of cardiac output-guided hemodynamic management on fluid administration after aneurysmal subarachnoid hemorrhage. Critical Care 2014;18 (Suppl 1), P455

97. A Sommese, J Bakker, J van Bommel, A Lima. CAROTID DOPPLER FLOW AND ITS DETERMINANTS DURING HEAD-UP-TILT CENTRAL HAPOVOLEMIA AND PASSIVE LEG RAISING IN HEALTHY VOLUNTEERS. INTENSIVE CARE MEDICINE 2014;40, S175-S176

98. E de Felice, L Woittiez, F Schierenbeck, A Oude Lansink, J Bakker, MW Nijsten. EARLY LACTATE AND GLUCOSE LEVELS AND SUBSEQUENT LIVER FAILURE AND MORTALITY IN CRITICALLY ILL PATIENTS. INTENSIVE CARE MEDICINE 201440, S82-S82

99. M Egal, A Lima, J van Bommel, J Bakker, ABJ Groeneveld. ASSOCIATION BETWEEN MAXIMUM DAILY LACTATE LEVELS AND DAILY SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE: A RETROSPECTIVE, OBSERVATIONAL STUDY. INTENSIVE CARE MEDICINE 2014;40, S117-S118

100. ME van Genderen, N Engels, A Lima, E Klijn, J Bakker, J van Bommel. EARLY PERIPHERAL PERFUSION TARGETED FLUID THERAPY LEADS TO LESS FLUID ADMINISTRATION IN PATIENTS IN WITH SEPTIC SHOCK: A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL. INTENSIVE CARE MEDICINE 2014;40, S129-S129

101. P Tapia, D Soto, A Bruhn, T Regueira, N Jarufe, L Alegria, JP Bachler, F Leon, C Vicuña, C Luengo, G Ospina-Tascón, J Bakker, G Hernandez. Early and severe impairment of lactate clearance in endotoxic shock is not related to liver hypoperfusion: preliminary report. Intensive Care Medicine Experimental 2 (Suppl 1), P12

102. S Dijkland, K Van Donkelaar, W Van den Bergh, J Bakker, D Dippel, M Nijsten, M Van der Jagt. Prognostic value of blood lactate and glucose levels after aneurysmal subarachnoid hemorrhage. Critical Care 2014;19 (Suppl 1), P466

103. JF Timsit, G Citerio, M Lavilloniere, A Perner, M Smith, S Ruckly, M Bassetti, J Bakker, D Benoit, JR Curtis, G Doig, M Herridge, S Jaber, L Papazian, M Peters, P Singer, M Soares, A Torres, A Viellard-Baron, E Azoulay. Determinants of downloads and citations for articles published in intensive care medicine. Intensive Care Medicine Experimental 2015;3 (Suppl 1), A863

104. G Hernandez, P Tapia, G Ospina-Tascón, A Bruhn, D Soto, L Alegría, N Jarufe, C Luengo, R Menchaca, A Meissner, MI Vives, J Bakker. Dexmedetomidine ameliorates gut lactate production and impairment of exogenous lactate clearance in an endotoxic sheep model. Intensive Care Medicine Experimental 2015;3 (Suppl 1), A414

105. G Citerio, C Marzorati, JF Timsit, A Perner, J Bakker, M Bassetti, D Benoit, JR Curtis, GS Doig, M Herridge, S Jaber, L Papazian, MJ Peters, P Singer, M Smith, M Soares, A Torres, A Vieillard-Baron, E Azoulay. Outcome of manuscripts rejected from intensive care medicine: an in silico study. Intensive Care Medicine Experimental 2015;3 (Suppl 1), A23

106. J Yang, A Dzierba, J Bakker, J Muir, D Brodie, N Yip. Evaluation of delirium monitoring in a medical ICU. Critical Care Medicine 2015;43 (12), 163

107. Amy Dzierba, Jan Bakker, Justin Muir, Lauren Wasson, Michael Colabraro, Whitney Gannon, Kathleen Connolly, Daniel Brodie. Ketamine use for sedation management in patients receiving extracorporeal membrane oxygenation. Critical Care Medicine 2015;43 (12), 150

108. L Meijs, A Bindels, A Roos, A Lima, J Bakker. Predicting fluid responsiveness in post-cardiac surgery patients. Critical Care Medicine 2015;43 (12), p32

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PRESENTATIONS 1990 Relation of mixed venous blood gases to tissue hypoxia and outcome in human septic shock. Belgian Society of Intensive Care Medicine: Annual meeting. Leuven, Belgium Relation of mixed venous blood gases to tissue hypoxia and outcome in human septic shock. Dutch society of Intensive Care. Utrecht. DO2 , VO2 and blood lactate as clinical guide to therapy in human septic shock. Dutch Intensive Care Congres (Venticare). Utrecht. Manipulation of oxygen delivery during mechanical ventilation in septic shock patients. Seminar Intensive Care Amsterdam. 1991 Effects of norepinephrine versus dobutamine in an experimental model of septic shock. Belgian Society of Intensive Care Medicine: Annual Meeting. Antwerpen, Belgium. Relationship between oxygen delivery and oxygen uptake. Seminar Erasme University Hospital Brussels, Belgium. O2-transport and consumption in septic shock. Symposium on catheter related sepsis. Rotterdam. The cardiovascular effects of anti-TNF antibodies. 11th International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. Oxygen transport and consumption in clinical septic shock. 11th International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium. Value of oxygen transport and consumption measurements during sepsis. Symposium on Intensive Care. Eindhoven. Dobutamine and norepinephrine administration in a dog model of endotoxic shock. 5th Meeting of European Shock Society, 14th Annual meeting of the Shock Society (USA), 3rd Vienna Shock Forum. June 1991 Vienna, Austria. Oxygen transport and consumption measurements are not neceserry in septic shock patients. Symposium on Intensive Care. Enschede. Oxygen consumption in septic shock patients. Course on circulation in intensive care patients. Dutch Society of Intensive Care Medicine, Free University of Amsterdam. Role of inotropes and vasopressors in the intensive care unit. Symposium on Intensive Care, Assen Supranormal values for oxygen transport and consumption in septic shock patients? Clinical conference, Amersfoort. Do we need to measure oxygen transport and consumption in critically ill patients? Course on circulation in intensive care patients. Dutch Society of Intensive Care Medicine. University of Utrecht. Pathogenesis of shock and sepsis. Symposium: Advances in Critical Care. London, U.K. Optimal oxygen transport and consumption during sepsis. Dutch Intensive Care Congres (Venticare). Octobre 1991 Utrecht. Cellular hypoxia in septic shock. Symposium on Intensive Care: The oxygen in the critically ill patient. Porto, Portugal. Pathogenesis of sepsis and septic shock. Symposium on the use of vasoactive drugs in septic shock, Hilversum. Monitoring tissue oxygenation. Research Lecture Department of Intensive Care Victoria Hospital London Canada Oxygen transport and consumption in sepsis. Course on circulation in intensive care patients. Dutch Society of Intensive Care Medicine. Symposium: Topics in Intensive Care Medicine, Amsterdam. 1992 Lactate monitoring in sepsis. Symposium. Beekbergen Relation between blood lactate levels and multiple organ failure. 12th International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. Relation between tissue hypoxia and multiple organ failure. Dutch Society of Intensive Care Medicine. Annual meeting. Value of blood lactate monitoring in septic shock. Symposium: Infection on the Intensive Care, Heemstede, Netherlands Tissue oxygenation. Course on circulation in intensive care patients. Dutch Society of Intensive Care Medicine. Ede, Netherlands Oxygen transport and consumption in sepsis. Course on circulation in intensive care patients. Dutch Society of Intensive Care Medicine. Symposium: Topics in Intensive Care Medicine, Amsterdam.

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Optimizing oxygen transport and consumption in preventing multiple organ failure. 6th Dutch Congres on Intensive Care, Utrecht Relation between tissue hypoxia and multiple system organ failure in septic shock (lecture) Principles of oxygen transport, consumption and extraction.(lecture) Multiple System Organ Failure Syndrome (round table) Supranormal values of oxygen transport and consumption in septic shock (meet the expert) Second Paulista Congres on Intensive Care, Sao Paulo, Brazilie 1993 How to optimize DO2 in septic shock. The place of N-acetylcysteine in sepsis 13th International symposium on Intensive Care and Emergency Medicine, Brussels, Belgium Tissue oxygenation in the critically ill patient. Dutch Society on Intensive Care, Rotterdam, Netherlands Does SvO2 reflect tissue oxygenation in critically ill patients. Dutch Society of Internal Medicine Annual meeting. Veldhoven, Netherlands. Tissue oxygenation in the critically ill patient. Dutch Society on Intensive Care, Zwolle, Netherlands Right ventricular ejectionfraction in critically ill patients. Manipulation of flow in septic shock. Patients in shock should be ventilated irrespective of their blood gas analysis. Dutch congres on Intensive Care, Venticare, Utrecht, Netherlands New developments in Intensive Care Medicine. Antonius Hospital Nieuwegein, Netherlands Principles of oxygentransport and oxygenconsumption in critically ill patients. Symposium on Intensive Care, Breda, Netherlands Oxygen Supply Dependency: Myth, Fact or Concept. Vth Portuguese Congress on Intensive Care and 2nd Iberian Meeting on Intensive Care Medicine, Porto, Portugal 1994 Optimizing tissue oxygenation in septic shock. Lecture University of Pittsburg, Department of Anesthesiology and Intensive Care, Pittsburg, U.S.A. Optimizing tissue oxygenation in septic shock. Lecture University of Texas Houston Health Science Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Houston, U.S.A. Principles of oxygentransport and consumption in critically ill patients. Circulatie cursus NVIC Right ventricular dysfunction in critically ill patients. Circulatiecursus NVIC Hemodynamics of shock. Teaching program Intensive Care Nurses. Almere NetherlandsMonitoring the critically ill patient, new techniques and insights. Case presentation: How to ventilate in severe ARDS. Dutch congres on Intensive Care, Utrecht Management of fluid resuscitation in the critically ill. Symposium Apeldoorn Right Ventricular Ejection Fraction and mixed venous oxygen saturation, new technologies in Intensive Care Medicine. Course on circulatory management of the critically ill patient. Rotterdam Hemodynamic monitoring. Past, present and future. Leiden New treatment modalities in sepsis and septic shock. Leiden 1995 Lactate monitoring. Symposium Blood gases monitoring, Rotterdam Hemodynamic monitoring in the critically ill patient. Nederlandse Internisten Dagen NIV, Veldhoven Optimizing the hight risk surgical patient. Sense or nonsense. Nederlandse Chirurgen Dagen, NVH, Veldhoven Multiple Organ Failure. Venticare Congres, Utrecht Right ventricular ejection fraction and continuous cardiac output monitoring. Avondsymposium Bennekom Circulatory and Respiratory failure in the prehospital phase. Education in Emergency Medicine, Amersfoort Right ventricular ejection fraction monitoring in the critically ill. Education in Intensive Care Medicien, Rotterdam Clinical application of right ventricular ejection fraction monitoring. REF/Volumetric status report and Future perspectives. Expert panel discussion. 8th European Congress of Intensive Care Medicine. Athens, Greece Right ventricular ejection fraction and regional circulation in critically ill patients. Boerhave cursus Leiden.

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1996 Renal Replacement Therapy. Course on Intensive Care. Rotterdam Right Ventricular Ejection Fraction and SvO2 measurements in critically ill patients. INCA cursus Rotterdam Hart-Long interacties tijdens mechanische beademing. Cursus Intensive Care Bennekom. De pathofysiology van perioperatieve darmischaemie. Avondsymposium Zwolle. Emergency Medicine and Trauma Care. Amersfoort Cardio-Pulmonary interactions during mechanical ventilation. Arnhem Possible benifits of monitoring Right ventricular ejection fraction. Workinggroup Clinical Physiological Monitoring. Pathofysiologie van shock. Cursus Intensive Care. Amersfoort Rechterventrikel ejectiefractie. Nieuwe ontwikkelingen in de intensive care. Boerhave Cursus Leiden. Indicatiestelling CVVH en deskundig gebruik van antistolling. Avondsymposium Maastricht Microvascular blood flow and tissue oxygenation. Applied Cardiovascular Physiology. APICE Triest, Italy. 1997 ICU costs. 17th International Symposium on Intensive Care and Emergency Medicine Brussel Immunomudulation in sepsis and ARDS: NO Synthase inhibition. 17th International Symposium on Intensive Care and Emergency Medicine Brussel Rechter ventrikel functie. INCA Intensive Care Symposium Amsterdam, Nl Gemengd veneuze zuurstof saturatie. INCA Intensive Care Symposium Amsterdam, Nl De relatie tussen darmischaemie en postoperatieve complicaties, Educational symposium Apeldoorn, Nl Clinical relevance of pulmonary artery catheters: aspects of cost effectiveness, Working group Clinical Physiological Monitoring, Brussel, B. Clinical effects of rTFPI administration in septic shock patients. Expert meeting, Brussel, B. Pathofysiologie van sepsis en septische shock. Nederlands Intensive Care Congres, Utrecht, Nl Ronde tafel conferentie: Behandeling van sepsis. Nederlands Intensive Care Congres, Utrecht, Nl Casus presentatie: Cardiogene shock. Nederlands Intensive Care Congres, Utrecht, Nl Administration of rTFPI in patients with septic shock. Expert meeting, Chicago, VS Cost-effectiveness of the PA-catheter. 2nd Vienna International Congress. Wenen, Oostenrijk NO synthesis inhibition in septic shock. 29th Gemeinsame Jahrestagung der Deutschen gesellschaft fur internistische intensivmedizin und notfallmedizin und der Osterreichischen gesellschaft fur internistische und allgemeine intensivmedizin. Leipzig, Duitsland Tonometry: What is it and what is it for? Lübeck, Duitsland Vloeistofresuscitatie met colloiden. Update. Avondsymposium Deventer Ziekenhuis. Deventer, Nl Effects of NO antagonists on ventricular function. Expert Meeting Chicago, VS ET-CO2 tijdens reanimaties. Bijscholing Ambulancedienst, Bussum, Nl. Cardiorespiratoire stoornissen in de ambulance hulpverlening. SOSA Amersfoort, Nl RV ejectiefractie en Continue cardiac output. Regionale refereeravond Academisch Ziekenhuis Nijmegen, Nl Klinische toepassingen vasoactieve medicatie. Casusbespreking. Topics on Intensive Care Ede, Nl 1998 Rechterventrikel ejectiefractie en gemengd veneuze zuurstofsaturatie. INCA cursus intensive care Leiden. Cost effectiveness in Intensive Care. 8th International Symposium on clinical intensive care medicine 1998. Bremen NO antagonisten tijdens septische shock. Avondsymposium Apeldoorn Behandeling van shock. GIC cursus Amersfoort Case Presentation. Expert panel Hemodyn program. Parijs, F. Principles of Tonometry. Tonometry state of the Art expert panel meeting. Londen, UK Use of tonometry in weaning. Tonometry state of the Art expert panel meeting. Londen, UK Kosten van multiple organ failure. 10e Internistendagen Veldhoven Pathofysiologie van shock. Nederlandse Vereniging voor Pathologie, Putten Clinical aspects of tissue oxygen delivery. Honorary lecture at the 11th Annual conference on Tissue Oxygen Metabolism. Tokyo, Japan Round table on tissue oxygen delivery. Satellite meeting 11th Annual conference on Tissue Oxygen Metabolism. Tokyo, Japan Curriculum Intensive Care, 10 masterclasses. University of Sao Paulo, Brazilië Hemodynamische bewaking. Apeldoorn.

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Monitoren en manipuleren van de oxygenatie van de darm. Basis Onderwijs Interne Geneeskunde, Amersfoort. 1999 Behandeling van septische shock. Nederlandse Intensivistendagen Garderen Hemodynamische bewaking. Refereeravond Ziekenhuis Zutphen Panel discussie: Toegang tot de Intensive Care. Academisch Ziekenhuis Utrecht 19th International Congres on Intensive Care and Emergency Medicine, Brussel. Clinical trials in sepsis: NO antagonists Lactate in surgery Tonometry in weaning Use of resources and costs of Intensive Care How to manipulate blood pressure inseptic shock Tutorial on tissue oxygen delivery and oxygen metabolism. Brussel Workshop on technology assessment. Development of standarts. Londen Gebruik van thrombolytica bij longembolien en perifere occlusie. Refereermiddag Raamsdonksveer. Cursus Hemodynamische Monitoring in 3 delen. 13e Nederlands Intensive Care Congres Utrecht Vloeistofresuscitatie. Cursus Algemene Intensive Care NVIC, Utrecht. ESICM Annual Congres Berlin Preload assessment in critically ill patients . Educational session Treatment of acute pancreatitis: an update VIII Jornada Sulbrasileira de Terapia Intensiva, Gramado, Brasil Monitoring blood lactate levels How to increase blood pressure in septic shock How to improve tissue oxygen delivery Multiple organ failure Masterclass: Tissue oxygenation University of Sao Paulo Faculty of Medicine, Brasil University hospital Sao Paulo Department of Intensive Care Treatment of sepsis an update. Albeda college Rotterdam End-points of fluid resuscitation. Symposium on the use of colloids. Lelystad Hart-lung interaction during intubation and mechanical ventilation. Refresher course department of Internal Medicine University Medical Center Utrecht. Interventions. Course on Evidence Based Medicine Apeldoorn. Case presentation on hemodynamics. Interactive symposium Dutch Society of Intensive Care. Ede. Development of intensive care medicine in The Netherlands. Symposium Utrecht 2000 Oxygen delivery and vasoactive pharmaceuticals in sepsis. 32 Gemeinsame Jahrestagung Gießen, Germany Tutorial: Oxygen delivery and hemodynamics in critically ill patients. Brussels Fluidresuscitation: Practical application. Regionale refereeravond Lelystad. Vasoactieve drugs in ICU patients, Annual Dutch Intensive Care Congress (doctors) Annual Dutch Intensive Care Congress (nurses) How to diagnose and monitor shock How to interpret blood lactate levels How to manipulate blood pressure Annual course for intensivists-in-training: Use of inotropes and vasopressors during sepsis Fluidresuscitation: Priciples and endpoints. Regionale refereeravond Delden Symposium on Sepsis, Trauma, Nutrition and Infection Endpoints of trauma resuscitation Lactic acidosis Chair: Pro-Con debate Treatment of community acquired pneumoniae Char: Pro-Con debate Selective Gut Decontamination Tutorial Intensive Care Rome. Acute Renal Failure in the ICU Diagnosing and treating tissue hypoxia

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Fluidresuscitation. Hoytema course Intensive Care, Deventer Lactate monitoring: COIG Internal Medicine, Amersfoort 2001 New developments of hemodynamic monitoring. Computer assisted diagnoses and treatment. Wintersymposium Zermat Switzerland. Hemodynamic monitoring in the ICU. Brussels Annual meeting Japanese Society of Intensive Care The role of inotropes in cardiac failure. A European view. How to diagnose, monitor and treat tissue hypoxia Nederlandse Intensivistendagen Opname en Ontslagbeleid Intensive Care 15th Dutch Intensive Care Congres on Nursing. Utrecht Course on Hemodynamics Evidence Based Medicine What is the optimal hematocrit in critically ill? Tecnology Assessment: Current status. Annual congres European Society on Intensive Care, Geneva Technology Assessment what do we expect from a new technology. Symposium on TA in the ICU. Pathophysiology of shock. Dutch training program Pathologists. Optimizing tissue oxygen delivery. Seminars in Yamaguchi, Kyoto, Nagoya, Saitama, and Sapporo, Japan Development of Intensive Care in the Netherlands. Dutch Society of ICU head nurses Computer assisted hemodynamic monitoring. Brussel 2002 Intensive care organization in the Netherlands. Symposium on ICU capacity in the Netherlands. Utrecht Hyperlactatemia and acidosis. Annual congres Dutch Intensive Care Society Pro-Con debate: The use of the PA-catheter improves quality of care. Annual congres Dutch Intensive Care Society Results of the Prowess study (aPC in severe sepsis). Annual congres Dutch Intensive Care Society Intensive Care capacity in the Netherlands. Results of a national study. Annual congres Dutch Intensive Care Society Current analgesic and sedative agents: Their use and limitations. The use of Ultiva in ICU patients: Putting theory into practice Symposium Brussels. Sepsis in the ICU. European round table discussion Brussels 22nd European symposium on Intensive Care and Emergency Medicine Brussels Costs of sepsis and organ failure Other methods to assess preload Could lactate levels reflect quality of care? Quality of life before and following ICU admission. European Society of Anaesthesiology. Nice France Nieuwe ontwikkelingen op het gebied van sepsis. Interactieve IC-bespreking: Spotting the spots. Groningen 15th Annual meeting European Society of Intensive Care Medicine Barcelona Spain. What should we monitor: Pressure, flow or volume Management of acute severe heart failure: an overview Tissue oxygen delivery. 4th Controversies in Anaestesia and Peri-Operative Medicien. Dingle Ireland Optimal oxygen delivery and consumption. Trauma, Sepsis, Infection and Feeding. Annual congres Dutch Intensive Care Society Septische shock: de laatste inzichten. COIG-studiedag Circulatie en Ventilatie Amersfoort De rol van de arteriapulmonalis catheter op de intensive care. 10e Wetenschapsdag Interne Geneeskunde Maastricht. Drotrecogin alpha voor severe sepsis. Doet het nationale protocol de zieke patient te kort. Refereeravond Intensive Care St. Radboud Nijmegen Behandeling van septische shock: Huidige richtlijnen. Update in ICU 2002 Antwerpen. 6e Deutscher Interdisziplinarer kongress fur intensivmedizin und notfallmedizin DIVI 2002, Hamburg Oxygen delivery and vasoactive drugs Microcirculatory abnormalities in sepsis

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2003 Winterworkshop Intensive Care, Villars Switzerland. Wanneer is cardiac output adequaat Open vs Closed format voor de intensive care Geactiveerd proteine C: voor wie? Hoe voorkomen we nosocomiale pneumonien? 5e Bloedgas symposium Radiometer, Zwolle Praktische toepassing van lactaat metingen Intensivistendagen, Papendal Arnhem Lactaat acidose: klinische implicaties en behandeling Update in ICU 2003: Acute Heart Failure What is preload and how to achieve it Venticare 2003, Utrecht Criteria voor opname en ontslag van Intensive Care afdelingen Casus presentatie: End of life PFI: Een indicator van de perifere circulatie Casus presentatie: falen van de hemodynamiek Neurologie en Traumatologie, Garderen Capaciteits problemen op intensive care afdelingen Ziekenhuis Assen Indicatie voor geactiveerd proteine C bij patienten met sepsis Ziekenhuis Hengelo Het indicatiegebied voor geactiveerd proteine C bij patienten met een sepsis Hoe verkrijg ik budget voor dure geneesmiddelen? European Summer course E Lilly, Rome Italy Which patient will benefit from activated protein C and how to identify these patients 2nd Summer conference in Intensive Care ESICM and SCCM, Nice France Combining DO2 and VO2: the hemodyn approach Course on hemodynamics for intensivists, South African Society of Intensive Care Flow and Metabolic endpoints: The basics of resuscitation 16th Annual Meeting European Society of Intensive Care Medicine Amsterdam. Technology assessment of blood lactate monitoring. X Jornada Sulbrasileira de Terapia Intensiva. Gramado Brasil. Preload assessment How to prevent nosocomial pneumonia Who should be admitted to an intensive care unit? Dopamine or Noradrenaline in septic shock Hyperlactatemia Drotrecogin-alfa The relevance of monitoring cardiac output 2004 Winter Workshop Intensive Care aPC is een zinvolle toevoeging aan ons therapeutisch arsenaal De falende circulatie European symposium on Intensive Care and Emergency Medicine Brussels How to improve data interpretator? Daily CRP Quality of life in the ICU Blood lactate tutorial Monitoring the microcirculation Masterclass Intensive Care, Amsterdam: Hemodynamic monitoring Pro-Con debate on the PA-catheter

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Workshop: Lactate monitoring International Symposium Monitoring. Brazilie. Ratinal use of the PA-catheter Lithium dilution to measure cardiaal output Microcirculation and OPS Increased lactate: What does it tell us? Diagnosis and treatment of Acute Right Ventricular Failure 2005 Winter Workshop Intensive Care LNMMA in septic shock Kwaliteit van leven voor, tijdens en na de IC Noninvasieve beoordeling van de circulatie Obducties bij IC patienten 25th European symposium on Intensive Care and Emergency Medicine Brussels Round table conference: My intensive care unit in 2015. Interfacing hemodynamic variables Costs of sepsis How to assess the microcirculation at the bedside Blood lactate tutorial PA-catheter: my favorite hemodynamic tool Vascular reactivity Course on Acid-Base Physiology. Danisch Society for Clinical Biochemistry, Denemarken. Blood lactate monitoring European Congress of Trauma and Emergency Surgery, Rotterdam. Can prehospital diagnosis and management of circulatory failure be improved Monitoring the microcirculation XI Jornada Sul Brasileira de Terapia Intensiva, Brazilie. Peripheral circulation in septic shock Quality of life of ICU patients Hemodynamic monitoring Topics in Intensive Care, Lunteren. Kosten van Intensive Care Surviving sepsis campain, Ede. Diagnosie, incidentie en kosten van sepsis Vroege hemodynamische behandeling van sepsis 2006 Winter Workshop Intensive Care Swan-Ganz: De laatste keer Monitoring bij septische shock Computer ondersteuning bij de behandeling 26th European symposium on Intensive Care and Emergency Medicine Brussels Outreach: The pro’s and con’s Would ICU’s cope with major epidemics? Minimally invasive autopsies 19th Annual Meeting European Society of Intensive Care Medicine Barcelona. Analgosedation in critically ill patients: Clinical and organizational effects

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34th Annual Meeting of the Japanese Association for Acute Medicine Monitoring of the peripheral circulation in the critically ill International Consensus Conference: Haemodynamic monitoring in shock and implications for management. Paris Is lactate (or base excess) a useful measurement in a shocked patient? 2007 Winter Workshop Intensive Care Pro-Con microcirculatie Terminale sedatie en euthanasie: test uw kennis Is intensive care een dure voorziening? Intensivistendagen Year in review: Hemodynamics World congres of the abdominal compartment syndrome. Antwerpen The role of lactate in abdominal sepsis Interactive case studies in organ allure 27th European symposium on Intensive Care and Emergency Medicine Brussels End-of-Life: Treatment plans We need a follow-up clinic Preparing for the next pandemie How to merge ICU’s Monitoring the peripheral circulation World congres on disaster and emergency management. Amsterdam Intensive care capacity in disasters 12th International Symposium on Infections in the Critically Ill Patient. Volume status and fluid resuscitation: what's the solution 20th Annual Meeting European Society of Intensive Care Medicine Berlin. Monitoring I: Macrocirculation Short acting drugs for analgosedation: Clinical and organisational effects Circulatiedagen NVIC Pro-Con lactaat Topics in Intensive Care Workshop SG-catheter Surviving sepsis Ontwikkelingen in hemodynamische monitoring bij sepsis Intensive Care Society London Analgesia led sedation in intensive care 2008 Winter Workshop Intensive Care, Villars (Ch) Praktische evaluatie van de circulatie Diagnostiek van nierfalen ScvO2 en SvO2 Intensivistendagen Mechanische ondersteuning van het falende hart: de beademingsmachine Educational Workshop NIRS, Hutchinson VS Physiology and Pathophysiology of the circulation in critically ill patients International Symposium on Critical Care and Emergency Medicine Brussels Round table conference: Defferred consent in critical care research Basic hemodynamic monitoring End of life: Do we need a protocol Tools to guide resuscitation: Skin temperature Lactate levels to guide resuscitation Werkgroup Educatieve Symposia, Rotterdam

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Besliskunde / richtlijnen bij volwassenen met ernstige respiratoire insufficiëntie: beademing of niet? 9e Bloedgassymposium, Nijmegen Is een lage PO2 een probleem? Schakels in de zorg. Regionaal symposium Rotterdam Waarom NICE registratie? Portugese society of Intensive Care St Eulalia Portugal Critical Care Emergency Centers: a good idea? Lactate levels to guide therapy Vasodilators in shock? Shock society, Koln Germany Regional or peripheral indicators of perfusion in critically ill patients? European Society of Intensive Care Medicine, Lisbon Portugal StO2 in emergency medicine Indicators of peripheral perfusion Integrating the microcirculation and regional circulation Keep an eye on oxygen balance: ScvO2 Variations across different contexts? Day vs Night: Severity scores and triage MAC refresher course, Rotterdam New CPR guidelines XIV Jornada Internacional de Terapia Intensiva, Porto Alegre Brasil Lactate directed therpay Resuscitation of the hight risk patient Parameters of peripheral perfusion Ethics in end-of-life Sociedad Argentina de Terapia Intensiva, Jornada del comite de shock y sepsis, Buenos Aires Argentina Objectives of intial resuscitation Analgosedation in critically ill ventilated patients 2009 Winter Workshop Intensive Care Villars (Ch) Initiele resuscitatie van de IC patient Het gebruik van NIRS bij IC patienten Vaso-actieve medicatie Symposium Gelre ziekenhuizen Apeldoorn Wanneer doe ik wat en waarom: over vocht, inotropica en vasopressoren Intensivistendagen Gebruik van Remifentanil bij intensive care patienten Hemodynamica, mijn favorieten: ScvO2 en Lactaat International Symposium on Critical Care and Emergency Medicine Brussels What is the cause of death in ICU patients Quality of life after sepsis End of life: we need a protocol Biomarkers of Renal failure Lactate levels to guide therapy What about the use of vasodilators? Monitoring of tissue perfusion: We should measure skin temperature Problems with informed consent in critical care research Symposium on analgesia and sedation Verona Italy The economics of remifentanil/propofol: department and hospital persperctive Educational course on the use of NIRS Padua Italy Physiology and pathophysiology of the circulation in relation to NIRS Applied Physiology in Intensive Care, San Fransisco Monitoring of ScvO2 and lactate

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Peripheral perfusion in shock Near Infrared Spectroscopy in critically ill patients Cardiology and Vascular Medicine, Update and Perspective, Rotterdam We should use high dose inotropes in cardiogenic shock Intensive Care Society UK, Manchester Analgosedation: clinical and organizational effects Beslissingen ronde het levenseinde: Medisch zinloos handelen Wat is zinloos handelen op de IC? Mag ik de Olympische Spelen nog zien? Case Presentation HTI Physician Education, South Beach USA Clinical application of StO2 measurements HTI Physician Education, Paris France Physiology of the microcirculation Clinical application of StO2 measurements COEUR Course Intensive Care Research, Rotterdam Physiology of the critically ill European Society of Intensive Care Medicine, Vienna Austria Noninvasive assessment of stroke volume during fluid resuscitation in critically ill patients International Sepsis Forum (ISF), Amsterdam Prevalence and incidence of severe sepsis in Dutch intensive care units 2010 Winter Workshop Intensive Care Alpbach (A) Evidence bases medicine Lactaat De periferie van de IC patient Low StO2 must be investigated Klinische fysiologie bij IC patienten Intensivistendagen Minimaal invasie obductie bij IC patienten Guiding Resuscitation Erasme University Hospital Brussel A low StO2 must be investigated Guiding Resuscitation Decisions New York Bedside physiology of tissue oxygenation for ICU nurses Bedsige physiology of tissue oxygenation and monitoring for ICU doctors A low StO2 must be investigated 1st International Symposium on Microcirculation, Sao Paulo Assessment of the microcirculation by physical examination Lactate as a therapeutic target Is there an impact of blood pressure on microcirculatory perfusion? 8th SIMUTI symposium, Sao Paulo Non invasive monitoring: Is there a place for NIRS? International Symposium on Critical Care and Emergency Medicine Brussels Ending life-support: Could we do it earlier? Improving management of septic shock: Nitrates Lactate revisited: How can lactate levels guide therapy? Microcirculation: Assessment of the peripheral circulation Renal failure: NGAL as an early biomarker Cardiogenic shock: Norepinephrine is good 15th Portuguese Symposium on Infection and Sepsis A rapid resonse system for sepsis: Should and can we take it to the pre-hospital setting? Early recognition and stratification of the septic patient: Lactate

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Resuscitation goals: beyond EGDT Guiding Resuscitation Decisions, Denver A complete guide to the sensible use of NIRS in critically ill Internistendagen 2010 Lactaat geleide therapie Guiding Resuscitation Decisions, Chicago A complete guide to the sensible use of NIRS in critically ill Guiding Resuscitation Decisions, New York A complete guide to the sensible use of NIRS in critically ill Grand Rounds New York Presbyterian Hospital, Columbia University Bedside physiology for intensivists Biomarkers in the optimization of critically ill patients 23rd Annual Congress of the European Society of Intensive Care Medicine, Barcelona Managing haemodynamics in severe sepsis and septic shock: Cardiac output or lactate driven care? Columbia University Medical Center. StO2 rapid non-invasive perfusion assessment A low StO2 needs further investigation Klinische ethiek op de IC, Utrecht Spraakverwarring, multiculturele intensive care Grand Rounds New York Presbyterian Hospital Tissue oxygenation Lactate as a guide to early goal directed therapy Organ donation Journalclub: AJRCCM Jansen et al. 2010 2011 Winter Workshop Intensive Care Alpbach (A) PRO-CON debate: Lactate should be used as a guide to therapy in critically ill Cardiac output Physiology of cardiac output International Symposium on Critical Care and Emergency Medicine Brussels (BE) Oximetry in clinical practice Can we predict Acute Kidney Injury Tutorial on Lactate monitoring The ICU patient could be a living kidney donor How to measure liver blood flow Monitoring in sepsis: has anything changed? Mean Systemic Filling pressure monitoring in critically ill Lactate Quiz Effect of blood transfusion on the microcirculation How to avoid hypotension during renal replacement therapy Minisymposium Sepsis, april 22nd Rotterdam (NL) Hemodynamic monitoring and treatment of sepsis. Functional hemodynamics and Fluid Therapy, Istanbul (Turkey) The importance of the peripheral circulation Lactate: its meaning and use in guiding therapy

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Grand rounds Dallas (USA) The importance of measuring lactate in critically ill Symposium on tissue oxygen monitoring. Houston (USA) Monitoring tissue oxygenation with NIRS. Venticare National Congress for nurses, Utrecht (NL) Be awake or asleep in the ICU? 25 years of vasoactieve drugs Use of ScvO2 and lactate in the initial resuscitation Grand Rounds University Rio Grande Sul, Porto Alegre (Brazil) How to evaluate perfusion in shock states Lactate is a tool in critical care Monitoring of the microcirculation 6th Course on Intensive Care, Catholic University Chili, Santiago (Chili) Interpretation of lactate levels Use of lactate levels as a therapeutic end point Society of Critical Care Anesthesiologists, Chicago (USA) The use of vasodilators in shock European society of intensive care, Berlin (Germany) Postgraduate course on hemodynamics Understanding Preload Optimizing the microcirculation 1st Fluid Academy, Antwerpen (BE) The search for the Holy Grail continues: is there a place for lactate? Visiting Professor Inselspital, University Hospital, Bern (CH) New York Presbyterian, New York (USA) University Hospital Minneapolis, Minneapolis (USA) Grand Rounds: How to understand hemodynamics: interactive case presentations Physiology of oxygen delivery Lactate as an end-point of resuscitation How to best improve oxygen delivery in shock? The use of selective gut decontamination Understanding Guyton and Starling 2012 Winter Workshop Intensive Care, Alpbach (A) The use of vasodilators in critically ill Pro-Con debate: The hemodynamic surviging sepsis guidelines make sense..YES Interactive case discussion: Hemodynamic monitoring using Guyton Society of Critical Care Medicine, Houston (USA) Industry sponsored session NIRS: Its use in critically ill Annual Dutch Intensive Care Society Meeting, Ede (Nl) The year in review 2011: Hemodynamics International Congress on Intensive Care and Emergency Medicine, Brussels (BE) Post Graduate Course on Hemodynamics: Oximetry Early Goal Directed Therapy: Add lactate levels Targeted Resuscitation: Lactate levels Lactate revisited: Metabolism Deferred consent in emergency research Tutorial: Tissue Oxygenation

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Blood pressure: Low good be good What affects the microcirculation: Temperature Organ donation: How to increase supply Advanced hemodynamics: Case presentations Annual Dutch Society of Internal Medicine, Maastricht (Nl) Early resuscitation of sepsis: ER or ICU? Post-Graduate Course ESICM in Advanced Hemodynamics, Bern Ch Hemodynamic stability Adequacy of perfusion Fluid responsiveness Nationale Practitioners Dag Delft Inotropie en survival XXX National Meeting Society of Critical Care Chili Optimizing tissue oxygenation Near Infrared Spectroscopy Ethics and end-of-life care Vasodilators in shock Lactate ESICM 25th annual meeting, Lisbon Postgraduate course in advanced hemodynamics Understanding preload Optimizing tissue oxygenation VIII National Meeting Society of Emergency Medicine Italy, Rimini Understanding Cardiac Output Lactate monitoring Tutorial on tissue oxygenation Effect of blood transfusion on the microcirculation Internet Education: Webinar on tissue oxygenation USA critical care phycisians Visiting Professor – Grand Rounds New York Presbyterian June and December The importance of venous return Monitoring peripheral circulation Selective Gut Decontamination Optimizing Tissue Oxygenation Recognizing hemodynamic instability Use of vasopressors in septic shock Lactate levels as a target in critically ill Hadassah University Hospital Jerusalem and Rambam Medical Center Haifa Analgosedation in clinical practice Catholic University Chili, Santiago (Chili) Monitoring lactate levels in critically ill Optimizing tissue oxygenation in critically ill Monitoring peripheral circulation University hospital Kiel, Germany Grand Rounds: Guytonian circulation

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London Hospital, London UK The importance of Mean Systemic Filling Pressure ZNA Stuivenberg, Antwerp Lactate monitoring and lactate as a therapeutic target. 2013 Belgian Society of Intensive Care End-of-life care in the Netherlands FRACTA 2013, Prague (CZ) The microcirculation in shock Metabolic endpoints of fluid resuscitation Indian Society of Critical Care Medicine, Pune (India) International Symposium on Intensive Care and Emergency Medicine Brussels Venticare (Utrecht) Israeli Society of Intensive Care Medicine Selective decontamination of the gut: fundamentals and clinical aspects Diploma on Intensived Care Medicine, Santiago Chile Classification of shock Peripheral perfusion in critically ill Fundamentals of lactate monitoring Macrohemodynamics and perfusion Annual Meeting European Society of Intensive Care Paris ACEM 2013 Tokyo (Japan) Lactate monitoring Visiting Professor – Grand Rounds University Hospital Ghent (B) The Guytonian circulation Free University Hospital Brussels (B) Mean Systemic Filling Pressure Cleveland Clinic (USA) The use of vasodilators in circulatory failure New York Presbyterian (USA) (May and December) Use of vasopressors, end-points of resuscitation University Hospital Prague Guyton at the bedside Catholic University Chili, Santiago (Chili, July-August) Guyton at the bedside Yamaguchi University Medical Center

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The use of Remifentanyl in critically ill patients Presbyterian New York Grand Rounds Medicine Cornell: Peripheral Circulation Grand Rounds Intensive Care Columbia: Functional liver blood flow Fellows, Residents and Nursing Education: Lactate levels End of Life Care Infection Control Use of vasopressors and inotropes Guyton Physiology at the bedside Peripheral circulation 2014 XIX course on Emergency Medicine, Naples (Italy) International Symposium on Intensive Care and Emergency Medicine Brussels Venti Care National Nursing Congress on Intensive Care and Emergency Medicine Limburg society of Intensive Care Nursing South African Congress on Critical Care The Use of ECMO in critically ill patients (6 times regional meeting Netherlands) 27th Annual Meeting European Society of Intensive Care (Barcelona) International ICU Course. Catholic University Santiago Chile. National congress Chilean Critical Care Society 1st Dutch Sepsis Congress Fall Meeting Dutch Society of Intensive Care 2015 35th International Symposium on Intensive Care and Emergency Medicine Brussels Symposium Apeldoorn, Netherlands Venti Care National Nursing Congress on Intensive Care and Emergency Medicine Congres der Lage Landen, Ghent Belgium S American Research Meeting (Chile) 8th Latin American ISICM (Sao Paulo) South Brazilian Congress on Intensive Care 28th Annual Meeting European Society of Intensive Care (Berlin) 2016 Course on Tissue Perfusion. Gothenburg Sweden. 36th International Symposium on Intensive Care and Emergency Medicine Brussels. B Venti Care National Nursing Congress on Intensive Care and Emergency Medicine. NL Swiss National Critical Care Meeting Montreux Switserland. Ch 29th Annual Meeting European Society of Intensive Care (Milan). IT Endpoints of resuscitaton in Septic Shock, Abu Dhabi Global Health Conference.UAE Clinical endpoints of Resuscitation, Abu Dhabi Cleveland Clinics Grand Rounds. UAE 2017 01-2017 46th Annual Meeting Society of Critical Care Medicine, Honolulu, Hawai 03-2017 37th International Symposium on Intensive Care and Emergency Medicine Brussels. B 02-2017 Een dag om nooit te vergeten. 10 Years back in the future, Apeldoorn. NL 01-2017 4th Annual Meeting Iran Society of Critical Care, Tehran, IR 04-2017 Autumn Meeting of the Chilean Society of Intensive Care, Santiago Chile 06-2017 9th International Symposium on Intensive Care and Emergency Medicine for Latin America, Sao Paulo, Brazil 08-2017 Course on Hemodynamics for residents. Catolic University Chile, Santiago

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09-2017 Advanced course on Hemodynamics for intensivists, Catholic University Chile, Santiago. 09-2017 30st Annual meeting of the European Society of Intensive Care, Vienna Austria 2018 01-2018 5th Annual Meeting Iran Society of Critical Care, Tehran, IR 02-2017 46th Annual Meeting Society of Critical Care Medicine, San Antonio. USA 03-2018 38th International Symposium on Intensive Care and Emergency Medicine Brussels. B 04-2018 Congresso Otoño Sociedad Chilena de Medicina Intensiva, Santiago Chile 06-2018 The future of Critical Care – A brainstorming Meeting, Edinburgh UK 06-2018 Hemodynamic Monitoring, San Jose Costa Rica 07-2018 Avances en Midicina Critica, Quito Equador 10-2018 31st Annual meeting of the European Society of Intensive Care, Paris, France