CURRICULUM VITAE

Carmen Chan, BSc, PhD Laboratory for Neuronal growth mechanisms RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Work phone #: +81-48-462-1111 E-mail: chanccm@gmail.com Academic background

09/2000 – 08/2006 PhD in Neuroscience University of British Columbia, Canada Graduate Program in Neuroscience

09/1996 – 04/2000 Bachelor of Science University of British Columbia, Canada

Physiology Honours

09/1996 – 04/1997 Science One Program University of British Columbia, Canada

Work experience

12/2007 – present Postdoctoral fellow Supervisor: Dr. Hiroyuki Kamiguchi

RIKEN Brain Science Institute, Japan Research on (1) axon guidance, growth cone turning and calcium signaling, and (2) dystrophic growth cone.

11/2006 – 11/2007 Postdoctoral fellow

Supervisor: Dr. Toshihide Yamashita Chiba University, Japan Spinal cord regeneration research: (1) proteolytic processing of a membrane-bound receptor, neogenin, to an inhibitory molecule, RGMa, and (2) effects of BMPs on injured axons.

09/2000 – 08/2006 Graduate Student Supervisor: Dr. Wolfram Tetzlaff International Collaboration On Repair Discoveries (ICORD), UBC

Spinal cord regeneration research: efficacy of Rho/ROCK inhibition in stimulating axonal regeneration in vivo.

05/2000 – 08/2000 Summer Research Student

Supervisor: Dr. Wolfram Tetzlaff

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Assisting senior graduate students on research projects: (1) regeneration-associated genes, and (2) effects, in vitro, of ROCK inhibition on neurite growth.

09/1999 – 04/2000 Undergraduate Research Student Supervisor: Dr. Kelly M. McNagny Biomedical Research Center, UBC

Hematopoietic stem cell lineage study: the role of MEP42 in determining cell fate

05/1999 – 08/1999 Summer Research Student Supervisor: Dr. Kelly M. McNagny

Hematopoietic stem cell lineage study. Journal Publications

1. Chan CC. Inflammation: beneficial or detrimental after spinal cord injury? (2008) Recent Pat CNS Drug Discov 3:189-199.

2. Chan CC, Roberts CR, Steeves JD, Tetzlaff W. (2008) Aggrecan components

differentially modulate nerve growth factor-responsive and neurotrophin-3-responsive dorsal root ganglion neurite growth. J Neurosci Res 86:581-592.

3. Chan CC, Wong AK, Liu J, Steeves JD, Tetzlaff W (2007) ROCK inhibition

with Y27632 activates astrocytes and increases their expression of neurite growth-inhibitory chondroitin sulfate proteoglycans. Glia 55:369-384.

4. Chan CC, Khodarahmi K, Liu J, Sutherland D, Oschipok LW, Steeves JD,

Tetzlaff W (2005) Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury. Exp Neurol 196:352-364.

5. McPhail LT, Fernandes KJ, Chan CC, Vanderluit JL, Tetzlaff W (2004) Axonal

re-injury reveals the survival and re-expression of regeneration associated genes in chronically axotomized adult mouse motoneurons. Exp Neurol 188:331-340.

6. Borisoff JF, Chan CC, Hiebert GW, Oschipok L, Robertson GS, Zamboni R,

Steeves JD, Tetzlaff W (2003) Suppression of ROCK activity promotes axonal growth on inhibitory CNS substrates. Mol Cell Neurosci 22:405-416.

Conference papers

1. Chan CC, Hata K, Endo M, Yamashita T (2007) Proteolytic processing of Repulsive Guidance Molecule, and its receptor, neogenin. Society For Neuroscience, San Diego, USA.

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2. Chan CC, Wong AK, Liu J, Steeves JD, Tetzlaff W (2005) Effects of ROCK inhibition with Y27632 on astrocytes. 11th International Symposium on Neural Regeneration, Asilomar, USA.

3. Chan CC, Wong AK, Liu J, Steeves JD, Tetzlaff W (2005) Effects of ROCK

inhibition on the non-neuronal cell population in the injured spinal cord. Society For Neuroscience, Washington DC, USA.

4. Chan CC, Khodarahmi K, Liu J, Sutherland D, Oschipok LW, Steeves JD,

Tetzlaff W (2004) Dosage-dependent effects of ROCK inhibition on axonal sprouting and functional recovery after spinal cord injury. 4th Asian Pacific Symposium on Neural Regeneration, Osaka, Japan.

5. Chan CC, Khodarahmi K, Liu J, Sutherland D, Oschipok LW, Steeves JD,

Tetzlaff W (2004) Dosage-dependent effects of ROCK inhibition on axonal sprouting and functional recovery after spinal cord injury. Society For Neuroscience, New Orleans, USA.

6. McNagny KM, Duhme C, Doyonnas R, Johnston J, Chan C, Merkens H (2000)

The CD34 family: proteins with related structure that play an essential role in murine development. 29th Annual scientific meeting of the International Society for Experimental Hematology. Tampa, Florida, USA.

Honours and awards

07/2007 – 06/2009 JSPS Postdoctoral Fellowship Japan Society for the Promotion of Science (JSPS) (International competition. 4,584,000 Yen per year x 2 years) 09/2003 – 08/2006 Canada Graduate Scholarships (CGS) Doctoral Award Canadian Institute of Health Research (CIHR)

(PhD studentship national competition – Doctoral Research Award, with the highest-ranking candidates being forwarded to the CGS)

$35,000 CAD per year x 3 years) 09/2003 – 08/2005 Rix Family Leading Edge Student Award (Provincial competition. Research award; $10,000 CAD) 09/2000 – 08/2003 BC Neurotrauma Initiative Rick Hansen Institute, Canada BC (PhD studentship provincial competition; $20,000 CAD per year x 3 years) 05/2000 – 08/2000 Undergraduate Student Research Award Natural Sciences and Engineering Research Council (NSERC) (National competition. $4,000 CAD)

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09/1996 – 04/2000 Dean’s Honour List for Academic Excellence, UBC (Recognition for students with standing of A- or better) 09/1996 – 04/2000 Outstanding Student Initiative Scholarship, UBC (Undergraduate scholarship; $2,500 CAD per year x 4 years) 09/1998 – 04/1999 Science Scholar Award, UBC (Recognition for students with standing of 90% or better) 09/1998 – 04/1999 Charles and Jane Banks Scholarship, UBC

(Research award; $400 CAD) Research interests and expertise

Axon guidance during mammalian nervous system development, spinal cord regeneration, intracellular signaling pathways (Rho GTPase, glycogen synthase kinase-3, calcium). Growth cone turning assays, focal laser-induced photolysis (FLIP), cell culture, animal surgery, behavioral analyses, immunohistochemistry, molecular genetics (vector construction, transfection), Western blotting.

Other science-related activities

Reviewing manuscripts for international, peer-reviewed journals. Supervision of a summer research student, year 2006. Mentoring a undergrad science student at the Life Sciences Research Tri-Mentoring Program, UBC, year 2006.

Volunteering at the 3D Microscopy of Living Cells at UBC organized by James Pawley, year 2004.

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References

Hiroyuki Kamiguchi, MD, PhD Team Leader, Lab. For Neuronal growth mechanisms

Brain Science Institute, RIKEN Telephone: +81-48-462-1111

Email: kamiguchi@brain.riken.jp

Wolfram Tetzlaff, MD, PhD Associate Director of ICORD Professor of Zoology and Neurosurgery University of British Columbia

Telephone: +1-604-675-8848 Email: tetzlaff@icord.org

John D Steeves, PhD Director of ICORD Professor, Zoology, Anatomy, and Neurosurgery

University of British Columbia Telephone: +1-604-675-8800 Email: steeves@icord.org

16 September 2009