G. Caligiuri - Curriculum Vitae

Giuseppina CALIGIURI Cardiologist, Research Director

47 years old, Italian, Married, 2 sonsInserm U 1148 - 46 rue Henri Huchard Paris, France 75018

T: +33 1 40 25 75 56 F: +33 1 40 25 86 02 E: giuseppina.caligiuri@inserm.fr : www.u1148.fr

R&D interest: innovative strategies for cardiovascular and chronic inflammatory disease

Therapeutic targets | Medical devices | Diagnostic tests

Recent Spotlight

On-going projects:

Development of a biomimetic stent surface (Coordinator of the IMPLANTS ANR program)

Development of a vaccine for atherosclerosis (French partner of the VIA UE FP7 program)

Development of a drug-candidate peptidomimetic for therapeutic and molecular imaging use in inflammatory conditions (patent portfolio)

Development of a diagnostic test for monitoring endothelial, leukocyte and platelet activation (patents)

Current position>2009 Research Director (DR2) at INSERM (Laboratory for Vascular Translational Science, LVTS)>1999 Cardiology Fellow (PATT, Univ. Hospital Bichat/Beaujon, Paris, FR)

Education and career2009-Today Career, academic,

scienceResearch Director (DR2, INSERM)

2006 Science, Education

Diploma of Research Director, Paris V University

2002- 2009 Career, academic, science

First Class Researcher (CR1, INSERM)

2000- 2002 Career, private, science

Permanent position as Senior Scientist in a Pharmaceutical Industry (Sanofi-Synthelabo)

1997-1999 Science, Education

PhD (“Cotutelle” between Karolinska Institute, Stockholm, SE and Univ. Paris 7, FR) date of thesis defense: 28/11/2000

1999-Today Hospital position, Medicine

Associated Fellow in the Cardiology department of the Univ. Hospital Bichat/Beaujon, Paris, FR

1993- 1997 Medical, Education

Post-graduate Specialization in Cardiology (Catholic University, Rome, IT)

September 1987-July 1993

Medical, Education

MD (Catholic University, Rome, IT)

Additional training2011 Advanced Flow cytometry and sorting (BD Biosciences, Erembodegem, Belgium)2010 In silico drug screening (Paris 7 University), Paris, France2006 Protein-protein interaction, advanced training (Paris 7 University), Paris, France2005 Habilitation for animal experimentation, including vital surgery, Paris, France2000 Echocardiography Inter-University Diploma, Creteil, France, 2000

1

G. Caligiuri - Curriculum Vitae

Patents and licensing G Caligiuri, A. Nicoletti. Detection of shed CD31, diagnosis of atherothrombosis and autoimmune disorders,

and methods for analyzing signaling pathways. WO 2010/000756 (PCT/EP2009/058220) G Caligiuri, A. Nicoletti. Use of CD31 peptides in the treatment of atherothrombosis and autoimmune

disorders. WO 2010/000741 (PCT/EP2009/058188) G Caligiuri, A Nicoletti. Detection of platelet-derived CD31. WO2013152919 (PCT/EP2013/055489) G Caligiuri, A Nicoletti. Improved CD31 peptides. WO 2013/190014 (PCT/EP2013/062806) G Caligiuri, A Nicoletti, JB Michel. CD31shed agonists for use in the prevention and/or treatment of

reperfusion injury. EP16305311 submitted on 21 March 2016. G Caligiuri, A Nicoletti, D Le Guludec, S Bay. CD31shed as a molecular target for imaging of inflammation.

EP16305516 submitted on 03 May 2016.

Scientific production

Original Articles1. Laguna-Fernandez, A., M. Carracedo, G. Jeanson, E. Nagy, P. Eriksson, G. Caligiuri, A. Franco-

Cereceda and M. Back "Iron alters valvular interstitial cell function and is associated with calcification in aortic stenosis." Eur Heart J. 2016 DOI: http://dx.doi.org/10.1093/eurheartj/ehw122 ehw122 First published online: 18 April 2016.

2. Clement M, Charles N, Escoubet B, Guedj K, Chauveheid MP, Caligiuri G, Nicoletti A, Papo T, Sacre K. CD4+CXCR3+ T cells and plasmacytoid dendritic cells drive accelerated atherosclerosis associated with systemic lupus erythematosus. J Autoimmun. 2015 Sep;63:59-67.

3. Clement M, Guedj K, Andreata F, Morvan M, Bey L, Khallou-Laschet J, Gaston A, Delbosc S, Alsac J, Bruneval P, Deschildre C, Le Borgne M, Castier Y, Kim H, Cantor H, Michel J, Caligiuri G, Nicoletti A. Control of the Tfh-GC B Cell Axis by CD8+ Tregs Limits Atherosclerosis and Tertiary Lymphoid Organ Development. Circulation. 2015 Feb 10;131(6):560-70.

4. Guedj K, Khallou-Laschet J, Clement M, Morvan M, Delbosc S, Gaston AT, Andreata F, Castier Y, Deschildre C, Michel JB, Caligiuri G, Nicoletti A. Inflammatory micro-environmental cues of human atherothrombotic arteries confer to vascular smooth muscle cells the capacity to trigger lymphoid neogenesis. PLoS One. 2014 Dec 30;9(12):e116295.

5. Clement M, Fornasa G, Loyau S, Morvan M, Andreata F, Guedj K, Khallou-Laschet J, Larghi P, Le Roux D, Bismuth G, Chiocchia G, Hivroz C, Newman DK, Nicoletti A, Caligiuri G. Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo. J Autoimmun. 2015 Jan;56:23-33.

6. Moreno JA, Ortega-Gomez A, Rubio-Navarro A, Louedec L, Ho-Tin-Noé B, Caligiuri G, Nicoletti A, Levoye A, Plantier L, Meilhac O. High Density Lipoproteins potentiate alpha-1 antitrypsin therapy in elastase-induced pulmonary emphysema. Am J Respir Cell Mol Biol. 2014 Oct;51(4):536-49.

2

G. Caligiuri - Curriculum Vitae

7. Guedj K, Khallou-Laschet J, Clement M, Morvan M, Gaston AT, Fornasa G, Dai J, Gervais-Taurel M, Eberl G, Michel JB, Caligiuri G, Nicoletti A. M1 macrophages act as LTbetaR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis. Cardiovasc Res. Mar 1 2014;101(3):434-443.

8. Clement M, Fornasa G, Guedj K, Ben Mkaddem S, Gaston AT, Khallou-Laschet J, Morvan M, Nicoletti A, Caligiuri G. CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells. Proc Natl Acad Sci U S A. Mar 25 2014;111(12):E1101-1110.

9. Faugeroux J, Nematalla H, Li W, Clement M, Robidel E, Frank M, Curis E, Ait-Oufella H, Caligiuri G, Nicoletti A, Hagege A, Messas E, Bruneval P, Jeunemaitre X, Bergaya S. Angiotensin II promotes thoracic aortic dissections and ruptures in Col3a1 haploinsufficient mice. Hypertension. 2013;62:203-8.

10. Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin C, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti S, Bruneval P, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, Silvestre JS, Mallat Z. B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. Nat Med. 2013;9:1273-80.

11. Fornasa G, Clement M, Groyer E, Gaston AT, Khallou-Laschet J, Morvan M, …& Caligiuri, G. A CD31-derived peptide prevents angiotensin II-induced atherosclerosis progression and aneurysm formation. Cardiovasc Res. 2012; 94:30.

12. Varthaman A, Clement M, Khallou-Laschet J, Fornasa G, Gaston AT, Dussiot M, Caligiuri, G. et al. Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses. PLoS One. 2011; 6(6): e21628.

13. Varthaman A, Khallou-Laschet J, Clement M, Fornasa G, Kim HJ, Gaston AT, Caligiuri, G. et al. Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells. J Immunol. 2010; 184(12): 6585-91.

14. Thaunat O, Patey N, Caligiuri G, Gautreau C, Mamani-Matsuda M, Mekki Y, et al. Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis. J Immunol. 2010; 185(1): 717-28.

15. Khallou-Laschet J, Varthaman A, Fornasa G, Compain C, Gaston AT, Clement M, …& Caligiuri, G. Macrophage plasticity in experimental atherosclerosis. PLoS One. 2010; 5(1): e8852.

16. Fornasa G, Groyer E, Clement M, Dimitrov J, Compain C, Gaston AT, …& Caligiuri, G. TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol. 2010; 184(10): 5485-92.

17. Deteix C, Attuil-Audenis V, Duthey A, Patey N, McGregor B, Dubois, V., Caligiuri, G., Graff-Dubois, S., Morelon, E., Thaunat, O. (2010) Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection. J Immunol 184: 5344-5351.

18. Navarrete A, Dasgupta S, Delignat S, Caligiuri G, Christophe OD, Bayry J, Nicoletti A, Kaveri SV, Lacroix-Desmazes S. Splenic marginal zone antigen-presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A. J Thromb Haemost. 2009 Nov;7(11):1816-23. Epub 2009 Aug 11.

19. Thaunat O, Louedec L, Graff-Dubois S, Dai J, Groyer E, Yacoub-Youssef H, Mandet C, Bruneval P, Kaveri S, Caligiuri G, Germain S, Michel JB, Nicoletti A. Antiangiogenic treatment prevents adventitial constrictive remodeling in graft arteriosclerosis. Transplantation. 2008 Jan 27;85(2):281-9.

20. Ephrem A, Chamat S, Miquel C, Fisson S, Mouthon L, Caligiuri G, Delignat S, Elluru S, Bayry J, Lacroix-Desmazes S, Cohen JL, Salomon BL, Kazatchkine MD, Kaveri SV, Misra N. Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis. Blood. 2008 Jan 15;111(2):715-22.

21. Thaunat O, Louedec L, Graff-Dubois S, Dai J, Groyer E, Yacoub-Youssef H, Mandet C, Bruneval P, Kaveri S, Caligiuri G, Germain S, Michel JB, Nicoletti A. Antiangiogenic treatment prevents adventitial constrictive remodeling in graft arteriosclerosis. Transplantation. 2008 Jan 27;85(2):281-9.

22. Groyer E, Nicoletti A, Ait-Oufella H, Khallou-Laschet J, Varthaman A, Gaston A-T, Thaunat O, Kaveri SV, Blatny R, Stockinger H, Mallat Z, Caligiuri G. Atheroprotective effect of CD31 receptor globulin through enrichment of circulating regulatory T cells. J Am Coll Cardiol, 2007, Jul 24;50(4):344-50.

23. Caligiuri G, Khallou-Laschet J, Vandaele M, Gaston A-T, Delignat S, Mandet C, Kohler HV, Kaveri SV, Nicoletti A. Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol, 2007, Aug 7;50(6):540-6.

24. Thaunat O, Louedec L, Jianping D, Bellier F, Groyer E, Delignat S, Gaston AT, Caligiuri G, Joly E, Plissonnier D, Michel JB, Nicoletti A. Direct and Indirect Effects of Alloantibodies Link Neointimal and Medial Remodeling in Graft Arteriosclerosis. Arterioscler Thromb Vasc Biol. Aug 17 2006.

25. G. Caligiuri., P. Rossignol, P. Julia, E. Groyer, D. Mouradian, D. Urbain, N. Misra, V. Ollivier, P. Boutouyrie, S. V. Kaveri, A. Nicoletti, and A. Lafont. Reduced Immunoregulatory CD31+ T Cells in

3

G. Caligiuri - Curriculum Vitae

Patients With Atherosclerotic Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):618-23.

26. J. Khallou-Laschet*., G. Caligiuri*, E. Groyer, E. Tupin, A. T. Gaston, B. Poirier, M. Kronenberg, J. L. Cohen, D. Klatzmann, S. V. Kaveri, and A. Nicoletti. The Proatherogenic Role of T Cells Requires Cell Division and Is Dependent on the Stage of the Disease. Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):353-8. * Equally contributed

27. J. Khallou-Laschet, E. Tupin, G. Caligiuri, B. Poirier, N. Thieblemont, A-T. Gaston, M. Vandaele, J. Bleton, A. Tchapla, S.V. Kaveri, M. Rudling, A. Nicoletti. Atheroprotective effect of adjuvants in apolipoprotein E knockout mice. Atherosclerosis. 2006 Feb;184(2):330-41.

28. J. Sainz, A. Al Haj Zen, G. Caligiuri, C. Demerens, D. Urbain, M. Lemitre, and A. Lafont. Isolation of "Side Population" Progenitor Cells From Healthy Arteries of Adult Mice. Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):281-6.

29. G. Caligiuri, E. Groyer, J. Khallou-Laschet, A. Al Haj Zen, J. Sainz, D. Urbain, A.T. Gaston, M. Lemitre, A. Nicoletti, A. Lafont. Reduced immunoregulatory CD31+ t cells in the blood of atherosclerotic mice with plaque thrombosis. Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1659-64.

30. J. Khallou-Laschet, G. Caligiuri*, E. Tupin, A.T Gaston, B. Poirier, E. Groyer, D. Urbain, S. Maisnier-Patin, R. Sarkar, S.V. Kaveri, S. Lacroix-Desmazes, A. Nicoletti. Role of the intrinsic coagulation pathway in atherogenesis assessed in hemophilic apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):e123-6. * Equally contributed

31. A. Al Haj Zen, G. Caligiuri, J. Sainz, M. Lemitre, C. Demerens, A. Lafont. Decorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice. Atherosclerosis. 2005 Sep 21; [Epub ahead of print]

32. Hemdahl AL, Caligiuri G, Hansson GK, Thoren P. Electrocardiographic characterization of stress-induced myocardial infarction in atherosclerotic mice. Acta Physiol Scand. 2005 Jun;184(2):87-94.

33. Durand E, Al Haj Zen A, Addad F, Brasselet C, Caligiuri G, Vinchon F, Lemarchand P, Desnos M, Bruneval P, Lafont A. Adenovirus-mediated gene transfer of superoxide dismutase and catalase decreases restenosis after balloon angioplasty. J Vasc Res. 2005 May-Jun;42(3):255-65.

34. G. Caligiuri, D. Stahl, S. Kaveri, T. Irinopoulous, F. Savoie, C. Mandet, M. Vandaele, M.D. Kazatchkine, J.B. Michel, A. Nicoletti. The autoreactive antibody repertoire is perturbed in atherosclerotic patients. Lab Invest 2003,83:939-947.

35. G. Caligiuri, M. Rudling, V. Ollivier, M.P. Jacob, J.B. Michel, G.K. Hansson, A. Nicoletti. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med 2003, 9 :10-17. (Cover of the issue).

36. E. Tupin, B. Poirier, M.F. Bureau, J. Khallou-Laschet, R. Vranckx, G. Caligiuri, Anh-Thu Gaston, J.P. Duong Van Huyen, D. Scherman, J. Bariéty, J.B. Michel, A. Nicoletti. Non-viral gene transfer of murine spleen cells achieved by in vivo electroporation. Gene Ther 2003, 10:569-579.

37. G. Caligiuri, A. Nicoletti, B. Poirier, G.K. Hansson: Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest. 2002; 109 :745-53.

38. G. Caligiuri, M. Rottenberg, A. Nicoletti, H. Wigzell, GK Hansson. Chlamydia pneumoniae infection does not induce or modify atherosclerosis in mice. Circulation 2001; 103: 2834-2838.

39. X. Zhou, G. Caligiuri, A. Hamsten, G. K. Hansson. Protection against Atherosclerosis by LDL Immunization is Associated with T cell Dependent IgG Antibodies in ApoE-deficient Mice. Arterioscl Thromb Vasc Biol, 2001; 21: 108-114.

40. E. Laurat, B. Poirier, E. Tupin, G. Caligiuri, G.K. Hansson, J. Bariéty, A. Nicoletti, In vivo inhibition of Th1 differentiation blocks the development of atherosclerosis in apoE knockout mice. Circulation 2001, 104; 2: 197-202.

41. G. Caligiuri, G Paulsson, A Nicoletti, A Maseri, G.K. Hansson. Evidence for antigen-driven T-cell response in unstable angina. Circulation, 2000; 102: 1114-1119.

42. A. Nicoletti, G. Paulsson, G. Caligiuri, X. Zhou, G. K. Hansson. Induction of neonatal tolerance to oxidized lipoprotein reduces atherosclerosis in apoE knockout mice. Molecular Medicine, 2000; 6:283-290.

43. G. Caligiuri, B. Levy, J. Pernow, P. Thorén, G.K. Hansson. Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc. Natl. Acad. Sci. USA 1999; 96: 6920-6924.

44. G. Caligiuri, A. Nicoletti, X. Zhou, I. Törnberg, G. K. Hansson. Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient mice. Atherosclerosis 1999, 145:301-308.

45. G. Caligiuri, G. Liuzzo, L.M. Biasucci, A. Maseri. Immune system activation follows inflammation in unstable angina: pathogenetic implications. J Am Coll Cardiol 1998; 32:1295-1304

4

G. Caligiuri - Curriculum Vitae

46. Nicoletti, G. Caligiuri, I. Thörnberg, T. Kodama, S. Stemme, G. K. Hansson. The macrophage scavenger receptor type A directs modified proteins to antigen presentation. Eur J Immunol 1999; 29:512-521.

47. J. Jiang, P. Thorén, G. Caligiuri, G.K. Hansson, J. Pernow. Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide. Br J Pharmacol. 1999 Oct;128(3):637-646.

48. LM Biasucci, G Liuzzo, RL Grillo, G Caligiuri, AG Rebuzzi, A Buffon, F Summaria, F Ginnetti, G Fadda, A Maseri. Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 1999; 99:855-860

49. LM Biasucci, G Liuzzo, G Fantuzzi, G Caligiuri, AG Rebuzzi, F Ginnetti, CA Dinarello, A Maseri. Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of In-hospital coronary events. Circulation 1999; 99:2079-2084.

50. G Liuzzo, LM Biasucci, JR Gallimore, G Caligiuri, A Buffon, AG Rebuzzi, MB Pepys, A Maseri. Enhanced inflammatory response in patients with preinfarction unstable angina. J Am Coll Cardiol 1999 Nov 15;34(6):1696-1703

51. G. Liuzzo, A. Buffon, L.M. Biasucci, J.R. Gallimore, G. Caligiuri, A. Vitelli, S. Altamura, G. Ciliberto, A.G. Rebuzzi, F. Crea, M.B. Pepys, A. Maseri. Enhanced inflammatory response to coronary angioplasty in patients with unstable angina. Circulation 1998; 98:2370-2376

52. A. Nicoletti, S. Kaveri, G. Caligiuri, J. Bariety, G.K. Hansson. Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice. J Clin Invest 1998; 102:910-918.

53. AG Rebuzzi, G Quaranta, G Liuzzo, G Caligiuri, GA Lanza, JR Gallimore, RL Grillo, D Cianflone, LM Biasucci, A Maseri. Incremental prognostic value of serum levels of troponin T and C-reactive protein on admission in patients with unstable angina pectoris. Am J Cardiol 1998; 82:715-719.

54. F. Crea, L.M. Biasucci, A. Buffon, G. Liuzzo, C. Monaco, G. Caligiuri, A. Kol, G. Sperti, D. Cianflone, A. Maseri. Role of inflammation in the pathogenesis of unstable coronary artery disease. Am J Cardiol 1997; 80:10E-16E.

55. L. M. Biasucci, G. Liuzzo, G. Caligiuri, G. Quaranta, F. Andreotti, G. Sperti, W. van De Greef, A. G. Rebuzzi, C. Kluft, A. Maseri. Temporal Relation Between Ischemic Episodes and Activation of the Coagulation System in Unstable Angina. Circulation, 1996; 93: 2121-2127.

56. L. M. Biasucci, G. Liuzzo, G. Caligiuri, W. van de Greef, G. Quaranta, C. Monaco, A. G Rebuzzi, C. Kluft, A. Maseri. Activation of the coagulation system doesn't elicit a detectable acute phase reaction in unstable angina. Am J Cardiol, 1996; 77: 82-85.

57. L. M. Biasucci, G. D'Onofrio, G. Liuzzo, G. Zini, C. Monaco, G. Caligiuri, M. Tommasi, A. G Rebuzzi, A. Maseri. Intracellular neutrophil myeloperoxidase is reduced in unstable angina and acute myocardial infarction, but its reduction is not related to ischemia. J Am Coll Cardiol, March 1996; 27: 611-616.

58. G. Liuzzo, L.M. Biasucci, A.G. Rebuzzi, J.R.Gallimore, G. Caligiuri, G.A. Lanza, G. Quaranta, C. Monaco, M.B. Pepys, A. Maseri. The plasma protein acute phase response in unstable angina is not induced by ischemic injury. Circulation 1996, 94: 874-877.

59. L. M Biasucci, A. Vitelli, G. Liuzzo, S. Altamura, G. Caligiuri, C. Monaco, A. G Rebuzzi, G. Ciliberto, A. Maseri. Elevated Levels of IL-6 in Unstable Angina. Circulation, 1996; 94: 874-77.

60. L. M. Biasucci, G. Liuzzo, C. Monaco, G. Quaranta, G. Caligiuri, A. G. Rebuzzi, W. van de Greef, A. Maseri, C. Kluft. Plasmin-Antiplasim complex in prognostic eveluation of patients with unstable angina. Fibrinolysis 1994; 8 (Suppl 2): 126-127.

61. L. M. Biasucci, G. Liuzzo, G. Caligiuri, C. Monaco, G. Quaranta, G. Sperti, W. van de Greef, A. Maseri, C. Kluft. Frequent sampling by clear venipuncture in unstable angina is a reliable method to assess haemostatic system activity. Fibrinolysis 1994; 8 (Suppl 2): 142-144.

62. F. Crea, L.M. Biasucci, G. Liuzzo, G. Caligiuri, G. Sperti, A. Kol, A. G. Rebuzzi, F. Andreotti, D. Cianflone, A. Maseri. Interazione fra aterosclerosi e stimoli ischemici nella patogenesi delle sindromi coronariche acute. Cardiologia 1994 ;39: 173-178.

5

G. Caligiuri - Curriculum Vitae

Reviews and Text Book Chapters1. G. Caligiuri (Editor). Molecular basis of atherosclerosis. Chapter 14 of the European Society of

cardiology Text Book of Vascular Biology (Oxford University Press, in press)2. G Caligiuri, B Levy, A Nicoletti, JB Michel. Chapter 10 of the “Surgical management of aortic

pathologies”. Role of biomechanical stress in the pathology of the aorta (Springer, in press).3. Weber, C., E. Shantsila, M. Hristov, G. Caligiuri, T. et al. Role and analysis of monocyte subsets in

cardiovascular disease. Thromb Haemost 2016, 116(4): 626-637.4. Le Borgne M, Caligiuri G, Nicoletti A. Once Upon a Time: The Adaptive Immune Response in

Atherosclerosis-a Fairy Tale No More. Mol Med. 2015 Oct 27;21 Suppl 1:S13-8.5. Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O'Neill LA, Marelli-Berg

FM. The Cellular and Molecular Basis of Translational Immunometabolism. Immunity. 2015 Sep 15;43(3):421-34.

6. Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat ML, Boulanger CM, Caligiuri G, Dimmeler S, Egido J, Evans PC, Guzik T, Kwak BR, Landmesser U, Mayr M, Monaco C, Pasterkamp G, Tuñón J, Weber C; ESC Working Group Atherosclerosis and Vascular Biology. Novel methodologies for biomarker discovery in atherosclerosis. Eur Heart J. 2015 Oct 14;36(39):2635-42.

7. Kwak BR, Bäck M, Bochaton-Piallat ML, Caligiuri G, Daemen MJ, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ, Evans PC. Biomechanical factors in atherosclerosis: mechanisms and clinical implications. Eur Heart J. 2014;35:3013-3020.

8. Marelli-Berg FM, Clement M, Mauro C, Caligiuri G. An immunologist's guide to CD31 function in T-cells. J Cell Sci. 2013;126:2343-52.

9. Bäck M, Gasser TC, Michel JB, Caligiuri G. Biomechanical factors in the biology of aortic wall and aortic valve diseases. Cardiovasc Res. 2013;99:232-41.

10. Jondeau G, Arnoult F, Caligiuri G, Phan G, Charles J, Morgant C, Aumont MC. Practical management of heart failure with preserved ejection fraction. A modest proposal. Arch Cardiovasc Dis. 2013;106:345-8.

11. Nicoletti A, Khallou-Laschet J, Guedj K, Clement M, Gaston AT, Morvan M, Dutertre CA, Michel JB, Thaunat O, Caligiuri G. Lymphoid neogenesis in vascular chronic inflammation. Presse Med. 2013;42:558-60.

12. Nicoletti A, Caligiuri G, Ho-Tin-Noé B, Michel JB. [Should we block interleukin-1 in atherothrombosis?]. Med Sci (Paris). 2012;28:580-2.

13. Arnoult F, Phan G, Detaint D, Caligiuri G, Aumont MC, et al. (2010) [Hormonal theory of heart failure with altered systolic function]. Rev Med Interne 31: 721-725.

14. Caligiuri G, Nicoletti A (2010) Tregs and human atherothrombotic diseases: toward a clinical application? Arterioscler Thromb Vasc Biol 30: 1679-1681.

15. Varthaman A, Khallou-Laschet J, Thaunat O, Caligiuri G, Nicoletti A. [Atherogenesis: a dysimmune disease.] Med Sci (Paris). 2008 Feb;24(2):169-176.

16. Boisson-Vidal C, Zemani F, Caligiuri G, Galy-Fauroux I, Colliec-Jouault S, Helley D, Fischer AM. Neoangiogenesis induced by progenitor endothelial cells: effect of fucoidan from marine algae. Cardiovasc Hematol Agents Med Chem. 2007 Jan;5(1):67-77..

17. Michel, J. B., O. Thaunat, X. Houard, O. Meilhac, G. Caligiuri, and A. Nicoletti. 2007. Topological Determinants and Consequences of Adventitial Responses to Arterial Wall Injury. Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1259-68.

18. Boisson-Vidal, C., F. Zemani, G. Caligiuri, I. Galy-Fauroux, S. Colliec-Jouault, D. Helley, and A. M. Fischer. Neoangiogenesis induced by progenitor endothelial cells: effect of fucoidan from marine algae. Cardiovasc Hematol Agents Med Chem 2007; 5:67-77.

19. Caligiuri, G., and A. Nicoletti. 2006. Lymphocyte responses in acute coronary syndromes: lack of regulation spawns deviant behaviour. Eur Heart J 27:2485-2486.

20. Caligiuri G, Kaveri SV, Nicoletti A. IL-20 and atherosclerosis: another brick in the wall. Arterioscler Thromb Vasc Biol. Sep 2006;26(9):1929-1930.

21. Groyer EM, Caligiuri G, Laschet-Khallou J, Nicoletti A. [Immunological aspects of atherosclerosis.]. Presse Med. 2006;35:475-486.

22. Bayary J, Dasgupta S, Misra N, Ephrem A, Van Huyen JP, Delignat S, Hassan G, Caligiuri G, Nicoletti A, Lacroix-Desmazes S, Kazatchkine MD, Kaveri S. Intravenous immunoglobulin in autoimmune disorders: an insight into the immunoregulatory mechanisms. Int Immunopharmacol. 2006;6:528-534.

6

G. Caligiuri - Curriculum Vitae

23. Misra N, Bayary J, Dasgupta S, Ephrem A, Huyen JP, Delignat S, Hassan G, Caligiuri G, Nicoletti A, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV. Intravenous immunoglobulin and dendritic cells. Clin Rev Allergy Immunol. 2005;29:201-205.

24. Thaunat O, Caligiuri G, Nicoletti A, Michel JB. Complexity of antigenic determinants and humoral responses in vascular injury. Cardiovasc Res. 2005 Nov 1;68(2):183-5.

25. Caligiuri G, Kaveri S, Nicoletti A. When interleukin-18 conducts, the Preludio sounds the same no matter who plays. Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):655-7

26. G. Caligiuri, A. Nicoletti. Les lymphocytes et l’immunité spécifique dans l’athérosclérose. « Athérosclérose: Physiopathologie, Diagnostics et Thérapeutiques » Editons Masson, Paris, 2002; 8: 112-122.

27. G. Caligiuri. Role of the Immune response in atherosclerosis and acute coronary syndromes. Médecine Sciences 2004; 20: 175-182 (Cover of the issue)

28. G. Caligiuri, A. Nicoletti. [Origines infectieuses de l’athérosclérose] Médecine Thérapeutique, 2000; 6: 593-597.

29. A. Nicoletti, G. Caligiuri, G.K. Hansson: Immunomodulation of atherosclerosis: myth and reality. J Intern Med, 2000;247:397-405

30. A. Nicoletti, G. Caligiuri, G. Paulsson G, G.K. Hansson. Functionality of specific immunity in atherosclerosis. Am Heart J. 1999 Nov;138(5 Pt 2):438-443.

31. G. Caligiuri. Leukocytes, inflammation and atherosclerosis. Haematologica, 1998; suppl 9 ; 83:28-29 (Cover of the issue).

32. G. Caligiuri, G.K. Hansson. [Più del grasso poté l’antigene?]. Ricerca Roche 1997; 16:48-50.

7