curs an 5 pisici herpes si calici viroze
DESCRIPTION
Boli infectioase cu simptomatologie respiratorie, ale pisicilor, diagnostic metodologie si terapie, note de curs Boli infectioase anul 5, Dragos CobzariuTRANSCRIPT
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Foarte contagioasa
Localizata la nivel respirator superior
Cu prevalenta ridicata desi vaccinam
Transmitere prin aerosoli si contact direct
FHV are rezistenta scazuta in mediu
◦ Inactivat in 18-24 ore
Pisicile raman purtatoare si eliminatoare pana
la 21 de zile de la infectie
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Poxviridae
African swine fever virus
Herpesviridae
Adenoviridae
Papovaviridaefelineherpesvirus-1
porcine cytomegalovirus
equine herpesviruses -1,4
malignant catarrhalfever virus
bovine herpesvirus-1,2
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nucleocapsida
glicoproteine(gB, gC…gL)
anvelopa
Alphaherpesvirinae (BHV-1, EHV-1,4, FelineHV, CanineHV)
Se dezvolta rapidLatenta in SNC-neuroni
pericapsida
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reactivation
from
latency
replication in
epithelial cells
(rhinotracheitis)
Infection of
susceptible animal
establishment of
latency(infection for the first time)
systemiccell-associated
spread
infection of the fetus
-> abortionencephalitis
replication in
epithelial cells
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◦ Stranut
◦ Conjunctivita, catar
◦ Scurgeri nazale
◦ Febra
◦ Anorexie
◦ Depresie
◦ Leziuni corneene
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Ulcere Corneene
Keratite
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Sechestru corneal
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Treatment de sustinere
Antivirale in special in infectiile oculare-risc
Vaccinarea cea mai buna preventie
Oamenii pot fi vectori pasivi in transmiterea bolii la alte feline.
Anorexia este o problema
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Aparitia acestora in ordine cronologica: În primul rând: IgM Al doilea: IgA treia: IgG
Ac tip IgG neutralizanti pot fi prezenti pe tot parcursul vieții si duc la: Neutralizarea virusului infectios
Liza mediată de complement a celulelor infectate
Ac-IgG pot fi prezenti în laptele matern –imunitate puilor
TOATE clasele de Ac pot neutraliza virusul DAR NUMAI IgG și IgM pot media citoliza
În recuperarea rapida un rol important il are răspunsul imun CELULAR dovedit la animale agammaglobulinemice infectate cu FHV, dacă acestea au leucocitele in parametrii normali.
Limfocitele T citotoxice, celulele NK si macrofagele au rol important in evolutia acută și în infecții recurente
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Days after infection
5 10 15 20
temperature+
++
+
+
+
+
5 10 15 20
interferon
IgM
IgG
CMI
virus shedding
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Foarte contagioasa, rara la pisici mai mari de 1 an!
Stomatite Ulcerative adesea Afecteaza caile respiratorii superioare Virus Rezistent in mediu◦ Disinfectantele nu il distrug imediat◦ Supravietuieste mai multe zile in mediu
Transmitere prin contactul direct cu pisicile infectate
Vaccinarile reduc incidenta
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Agent etiologic - Calicivirusul felin virus ARN Prezinta Capsida nu si Pericpasida cu dim 35-40 nm,sim. Icosaedrala
Prezinta mai multe serotipuri ceea ce explica si de ce, vaccinul nu poate proteja complet impotriva tuturor tulpinilor de FCV
Diferitele tulpini de FCV - variază în virulență Unele sunt asociate cu infectia sublicinca, a aparatului respirator superiorCele extrem de virulente pot produce pneumonie in special la pisoii mici.
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SEMNE CLINICE dupa o incubatie de 6 zile◦ Febra
◦ Catar Ocular si Nasal
◦ Conjunctivite
◦ Ulcere ale cavitatii bucale, Stomatite
◦ Pneumonie
◦ Sindromul de schiopatat al pisoilor –consecinta afectarii sinoviilor articulare.
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Terapie de sustinere/complicatiile bacteriene
Vaccinarea este baza preventiei
Remiterea semnelor clinice dupa 5-7 zile
Vindecarea leziunilor cav. bucale dupa 5 zile
Anorexia trebuie combatuta
Purtatori si eliminatori inca 2-3 saptamani
Antivirale: Ribavirin, Interferon , Imunoglobuline
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Diagnosticul de certitudine se stabileste prin examene de laborator, care au două obiective,evidentierea virusului si evidentierea anticorpilor.
FCV poate fi evidentiat direct în materiale patologice (secretii, tesut pulmonar) prin microscopie electronică, prin izolare si cultivare, imunofluorescentă IF si prin PCR.
Virusul poate fi identificat prin virusneutralizare.
În epiteliile pentru care are tropism, FCV poate fievidentiat si imunohistochimic
Anticorpii specifici pot fi pusi în evidentă prin virus-neutralizare si prin testul imunoenzimatic (ELISA), seroconversia confirmând cu certitudine etiologia bolii .
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