curriculum vitae yiannis s. chatzizisis, md, phd, facc, … · 2018. 9. 30. · yiannis s....

YIANNIS S. CHATZIZISIS – CV – 2018-09-30

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CURRICULUM VITAE

YIANNIS S. CHATZIZISIS, MD, PhD, FACC, FAHA, FESC

Work address: Cardiovascular Division, University of Nebraska Medical Center, 982265

Nebraska Medical Center, Omaha, NE 68198

Cell: 857 234 2604

E-mail: [email protected]; [email protected]

EDUCATION

1994-2000 MD, Aristotle University Medical School, Thessaloniki, Greece

2002-2004 MSc, Medical Research and Technology, Aristotle University Medical

School, Thessaloniki, Greece

2004-2009 PhD, Aristotle University Medical School, Thessaloniki, Greece

POST DEGREE TRAINING

09/2005-08/2008 Postdoctoral Research Fellowship, Cardiovascular Medicine, Brigham and

Women's Hospital, Harvard Medical School, Boston, MA

06/2006-08/2008 Postdoctoral Research Fellow, Harvard-MIT Division of Health Science

and Technology, Massachusetts Institute of Technology, Cambridge, MA

05/2008-01/2012 Clinical Fellowship, Cardiovascular Medicine, AHEPA University

Hospital, Aristotle University Medical School, Thessaloniki, Greece

02/2012-05/2012 Clinical Fellowship, Cardiovascular Medicine, Brigham and Women's

Hospital, Harvard Medical School, Boston, MA

05/2012-01/2014 Clinical Fellowship, Advanced Non-Invasive Cardiovascular Imaging,

Cardiovascular Division, Brigham and Women's Hospital, Harvard

Medical School, Boston, MA

02/2014-07/2015 Clinical Fellowship, Interventional Cardiology, Cardiovascular Division,

Brigham and Women's Hospital, Harvard Medical School, Boston, MA

ACADEMIC APPOINTMENTS

2015-Present Associate Professor, Internal Medicine, Cardiovascular Division,

University of Nebraska Medical Center (UNMC), Omaha, NE

mailto:[email protected]

mailto:[email protected]


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CLINICAL APPOINTMENTS

2015-Present Attending Cardiologist, Cardiac Catheterization Laboratories,

Cardiovascular Division, University of Nebraska Medical Center, Omaha,

NE

2015-Present Attending Cardiologist, Cardiac CT/MRI Program, Cardiovascular

Division, University of Nebraska Medical Center, Omaha, NE

ADMINISTRATIVE APPOINTMENTS

2017-Present Director, Heart and Vascular Unit

2015-Present Director, Cardiovascular Biology and Biomechanics Laboratory

CERTIFICATIONS AND LICENSES

2015-Present Medical License Nebraska, 28658

2012-2015 Medical License Massachusetts, 250132

2013 Echocardiography (Level III), American Society of Echocardiography

2013 Cardiac CT (Level III), Society of Cardiac Computed Tomography

2013 Nuclear cardiology (Level II), American Society of Nuclear Cardiology

GRANTS AND CONTRACT SUPPORT

Completed

Title: Development and applications of quantifiable sympathetic vasomotion

Funding Agency: Nebraska Research Initiative

Project Period: 2016-2017

Total Dollars: $150,000

Role: Co-Principal Investigator

Ongoing

Title: Startup funding

Funding Agency: University of Nebraska Medical Center


Total Dollars: $1,000,000

Role: Principal Investigator

Title: Novel Targeted treatments of high risk atherosclerotic plaque via catheter-


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directed local treatment of high risk plaque using anti-inflammatory

nanoparticles

Funding Agency: UNL and UNMC Sciences, Engineering and Medicine Initiative




Title: Microscale Investigation of Mechanobiology of Atherosclerosis Using

Novel Microfluidic Biochambers

Funding Agency: University of Nebraska, Collaboration Initiative Seed Grant




Title: Morphologic comparison of HD IVUS vs. OCT

Funding Agency: Boston Scientific

Project Period: 2018


Pending

Title: Patient-specific simulations to guide coronary bifurcation stenting

Funding Agency: NHLBI

ID Number: 1R01HL144690-01 Application scored 7th percentile




Title: In-vitro Experimental and Computational Models for Multiscale

Investigation of Mechanobiology of Atherosclerosis

Funding Agency: AHA

ID Number: 18TPA34230014




OUTSIDE GRANTS

Completed

Title: Prediction of acute coronary events using non-invasive assessment of

endothelial shear stress with coronary CT angiography.

Funding Agency: Behrakis Foundation, Boston, MA

Institution: Brigham and Women's Hospital, Harvard Medical School



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Title: Combination of shear stress and molecular imaging of inflammation to

predict high-risk atherosclerotic plaque.

ID Number: FP7-PEOPLE-2009-RG/249303

Funding Agency: EU Marie Curie International Reintegration Grant

Institution: Aristotle University Medical School




Title: Automatic segmentation of intracoronary ultrasound

Funding Agency: Boston Scientific


Project Period: 2007



Title: Role of shear stress in the natural history of atherosclerosis

Funding Agency: Behrakis Foundation, Boston USA





Title: Prediction of progression of coronary artery disease and clinical outcome

using vascular profiling of shear stress and wall morphology

Funding Agency: Boston Scientific Inc.




Role: Co-Investigator

Title: The effects of valsartan alone and valsartan plus simvastatin on the

progression of coronary atherosclerosis in a diabetic porcine model

ID Number: CVAL489AUS59

Funding Agency: Novartis Pharmaceuticals Inc.




Role: Co-Investigator

CLINICAL TRIALS


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Title: Effect of Local Biomechanical Factors on Bifurcation Stent Restenosis

and Thrombosis (Flow ISR Study)

Funding Agency: Medtronic

Institution: University of Nebraska Medical Center



Title: Study of access site for enhancing PCI in STEMI for seniors (SAFE

STEMI for Seniors)

Funding Agency: Medtronic/Volcano/Terumo

Institution: Duke University Medical Center


Role: Site Principal Investigator

OTHER APPOINTMENTS AND POSITIONS

2000 - 2002 Internship, Internal Medicine, General Hospital of Trikala, Trikala, Greece

2002 - 2004 Obligatory Military Service, Primary care physician in Hellenic Air Force

2004 - 2005 Residency, Internal Medicine, Aristotle University Medical School,

Thessaloniki, Greece

HONORS AND AWARDS

International

2007 Norman Alpert Visiting Scientist Award, ESC

2008 Travel Award, ESC Congress, Munich, Germany

2008 Young Investigators Award (Finalist), ESC Congress, Munich, Germany

2009 Young Investigator Award, ESC Congress, Barcelona, Spain

2009 Travel Award, ESC Congress, Barcelona, Spain

2010 Young Investigator Award, European Atherosclerosis Society Congress,

Gothenburg, Sweden

2010 Young Investigator Award, ESC Congress, Stockholm, Sweden

2011 Young Investigator Award, ESC Congress, Paris, France

2011 Bernard and Joan Marshall Young Investigators Award, British Society of

Cardiovascular Research, London, UK

2012 Best Poster, ESC Congress, Munich, Germany

National

2006 Young Investigator Merit Award, AHA Scientific Sessions, Chicago, IL,

USA

2008 ATVB Merit Award for Young Investigators, ATVB Annual Conference,


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Atlanta, GA, USA

2009 Young Investigator Award, XV International Symposium on

Atherosclerosis, Boston, MA, USA

2014 Young Investigators Award, Society of Cardiovascular Computed

Tomography Annual Scientific Meeting, San Diego, CA, USA

Regional

2006 Michael Mulinos Postgraduate Award, Hellenic Medical Society of New

York, New York, New York, USA

2013 1st Award, George D. Behrakis Cardiovascular Symposium in Vascular

Biology, Boston, MA, USA

Local

2016 Best Teacher Award

2016 UNMC Faculty Mentoring Recognition Luncheon

Hellenic

2000 Greek State Scholarships Foundation, Athens, Greece

2003-2006 PhD Scholarship, Greek State Scholarships Foundation, Athens, Greece

2005-2006 PhD Scholarship, Aristotle University of Thessaloniki Research

Committee, Thessaloniki, Greece

2005-2006 Research Grant, Hellenic Harvard Foundation, Athens, Greece

2006-2008 Research Grant, Propondis Foundation, Athens, Greece


2006 Dr Frederick Valegrakis Research Grant, Hellenic University Club of

New York, New York City, NY


2007-2008 Research Grant, Alexander S. Onassis Public Benefit Foundation, Athens,

Greece

2007-2008 Research Grant, AG Leventis Foundation, Paris, France

2007-2008 Research Grant, Hellenic Atherosclerosis Society, Athens, Greece

2007-2008 Research Grant, Hellenic Heart Foundation, Athens, Greece

2007-2008 Research Grant, George D. Behrakis Research Fellowship, Boston, MA,

MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES

2006-Present Member, International Atherosclerosis Society

2007-Present Member, European Atherosclerosis Society

2008-Present Member, European Bifurcation Club

2010-Present Fellow, American Heart Association (FAHA)

2010-Present Fellow, European Society of Cardiology (FESC)

2010-2012 Member, International Society for Heart Research, International Society


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for Heart Research

2010-Present Member, ESC Working Group 06 - Coronary Pathophysiology and

Microcirculation, ESC Working Group

2010-2012 Member, British Society for Cardiovascular Research, British Society for

Cardiovascular Research

2011-Present Fellow, American College of Cardiology (FACC)

2011-Present Member, European Association of Percutaneous Coronary Interventions

2012-Present Member, American Society of Echocardiography

2013-Present Member, American Society of Nuclear Cardiology

2014 Conference organizer committee member, George D. Behrakis

Cardiovascular Symposium on Vascular Biology, Harvard Medical School

2012-2014 Vice president, Hellenic Cardiological Society, Working Group on Basic

2013-Present Member, American Society of Nuclear Cardiology

2016-Present Board Member, European Bifurcation Club

PATENTS

2017 Three-dimensional co-cultures as in-vitro models of atherosclerosis

(#17056)

2017 Drug delivery catheter for atherosclerosis disease (#18003P)

2017 Stitching device for trans-catheter vascular anastomosis (#18040P)

2018 Time-varying quantification of capacitive and resistive arterial blood flow

(#25714-00010P01)

LECTURES

Invited International Lectures

2007

Role of shear stress in the natural history of atherosclerosis. 3rd Scientific Conference of the

Atherosclerosis Association of Northern Greece, March 15-17, 2007, Thessaloniki, Greece

Role of low endothelial shear stress in the development of inflamed high-risk coronary

atherosclerotic plaques. Cardiovascular, Diabetes, and Metabolic Disorders Research Center

Weekly Seminar Series, BWH Biomedical Research Institute, Brigham and Women’s

Hospital, Harvard Medical School, December 05, 2007, Boston, MA, USA

A strategy for the prediction of vulnerable plaque. 4th Scientific Conference of the

Atherosclerosis Association of Northern Greece, February 21-24, 2008, Thessaloniki, Greece

2008


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In-vivo assessment of endothelial shear stress to predict development of high-risk plaque. 3rd

International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease,

April 24-25, 2008, Thoraxcenter, Rotterdam, Netherlands

Role of endothelial shear stress in the natural history of coronary atherosclerosis and

remodeling. European Bifurcation Club Meeting, September 26-27, 2008, Prague, Czech

Republic

2009

Role of elevated heart on coronary artery disease. 5th Scientific Conference of the

Atherosclerosis Association of Northern Greece, March 23-25, 2009, Thessaloniki, Greece

Role of Valsartan alone or in combination with Simvastatin in the development of coronary

atheromata with thin fibrous cap. 4th International Symposium on Biomechanics in Vascular

Biology and Cardiovascular Disease, April 16-18, 2009, Thoraxcenter, Rotterdam,

Netherlands

Pathophysiology of Vulnerable Plaque. 24th International Meeting on Clinical Cardiology,

Hellenic Heart Foundation April 23-25, 2009, Athens, Greece

Stent thrombosis and bifurcation stenting. Reasons for increased risk: Flow? 5th European

Bifurcation Club Meeting, October 16-17, 2009, Berlin, Germany

2010

Shear stress: From atherogenesis to vulnerable plaque formation and rupture. Guest Lecture –

January 23, 2010. Department of Radiology, Addenbrooke’s Hospital, University of

Cambridge, Cambridge, UK

Flow dynamic factors and vectors of neo intimal hyperplasia. 6th European Bifurcation Club

Meeting, October 22-23, 2010, Budapest, Hungary

Augmented expression and activity of extracellular matrix–degrading enzymes in regions of

low endothelial shear stress co-localize with coronary atheromata with thin fibrous caps in

pigs. 79th European Atherosclerosis Society Congress, June 24-28, 2010, Gothenburg,

Sweden

2011

Role of shear stress in matrix-degrading enzymes and vulnerable plaque development. British

Society of Cardiovascular Research, Autumn Meeting, September 5-6, 2011, London, UK

Shear Stress: From atherogenesis to vulnerable plaque. Midwest Atherosclerosis Prevention

Society, November Meeting, November 10, 2011, Kansas City, Missouri, USA


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2012

Bench testing and simulation to improve bifurcations stenting. 8th European Bifurcation Club

Meeting, October 12-13, 2012, Barcelona, Spain

2013

New Insights into the role of hemodyamics in plaque instability (keynote presentation). 81st

European Atherosclerosis Society Congress. June 2-5, 2013, Lyon, France

Patient-Specific Bifurcation Stenting Modeling. What for? To Predict Outcomes. 9th

European Bifurcation Club Meeting, October 18-19, 2013, London, UK

2014

Flow Modeling Based on 3D OCT Reconstructions. 10th European Bifurcation Club Meeting,

October 17-18, 2014, Bordeaux, France

2015

Multicenter Clinical Trial on the Impact of Biomechanical Factors on Bifurcation Stent

Restenosis and Thrombosis. 11th European Bifurcation Club Meeting, September 25-26,

2015, Athens, Greece

2016

Why, When and How I Should Manage a Patient with Bifurcation Lesion: Ten Steps. C3

Complex Cardiovascular Catheter Therapeutics June 28 - July 1, 2016, Orlando, Florida

Impact of Biomechanical Factors on Bifurcation Stent Restenosis and Thrombosis. C3

Complex Cardiovascular Catheter Therapeutics June 28 - July 1, 2016, Orlando, Florida

Mechanical and Flow Factors of In-Stent Hyperplasia: Introduction to Flow ISR Study. 12th

European Bifurcation Club Meeting, October 14-15, 2016, Rotterdam, Netherlands

2017

Wall Shear Stress and Stents. EPIC-SEC, April 20-22, 2017, Atlanta, Georgia

Patient-specific bifurcation stenting simulations. 13th European Bifurcation Club Meeting,

October 13-14, 2017, Porto, Portugal

Shear stress and vulnerability of atherosclerotic plaques. AHA Scientific Sessions, November

11-15, 2017, Anaheim, California


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2018

Cardiovascular simulations: Clinical perspectives and research opportunities. Emory Heart

and Vascular Grand Rounds, April 2, 2018, Atlanta

Local Lectures

Interventional Cardiology: Moderator of Cath Lab Conference (2015-present, weekly)

Non-invasive Cardiovascular Imaging: Moderator of Advanced Non-invasive Cardiovascular

Imaging Conference (2016-present, weekly)

2015

Cardiothoracic Surgery Journal Club, UNMC: What is complete surgical revascularization?

Is FFR a game-changer?

Cardiovascular Division Interventional Conference, UNMC: Vascular Biology of

Atherosclerosis and Stent Restenosis/Thrombosis

Cardiology Grand Rounds, UNMC: New Interventional Strategies

Internal Medicine Grand Rounds, UNMC: Computational Simulations and Cardiovascular

Disease

2016

Physiology Seminars, UNMC: Simulations of Flow Physiology and Atherosclerosis

DEM Research Conference, UNMC: Local Hemodynamics and atherosclerosis

Cardiology Grand Rounds, UNMC: Cardiac CT: Clinical Applications



Cardiovascular Division Interventional Conference, UNMC: Coronary artery vasculitis

2017

Cardiology Grand Rounds, UNMC: Myocardial Ischemia and Viability



Cardiovascular Division Interventional Conference, UNMC: Coronary artery vasculitis

Cardiovascular Division Interventional Conference, UNMC: Angiographic projections

Cardiovascular Division Interventional Conference, UNMC: OCT in Cardiology

Internal Medicine Residents Noon Conference, UNMC: Pericardial disease

Cardiology Grand Rounds, UNMC: Cardiovascular simulations


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EDITORIAL BOARDS

2008-2014 The Open Cardiovascular Medicine Journal

2009-2013 World Journal of Cardiology (Editorial board member)

2009-Present Vascular Health and Risk Management (Editorial board member)

2010-Present Expert Reviews on Cardiovascular Therapy (Editorial board member)

2010-Present Pharmacology and Therapeutics (Associate editor)

2013-Present Atherosclerosis (Associate editor)

SCIENTIFIC MANUSCRIPT REVIEWER

2005-Present International Journal of Cardiology

2006-Present American Journal of Cardiology

2007-Present Medical Engineering and Physics

2007-Present Journal of Cardiac Failure

2007-Present Canadian Journal of Cardiology

2007-Present European Journal of Clinical Investigation

2008-Present Current Medicinal Chemistry

2008-Present Annals of Noninvasive Electrocardiology

2008-Present Clinical Endocrinology

2008-Present Heart

2008-Present Atherosclerosis

2008-Present The Open Cardiovascular Medicine Journal

2008-Present British Journal of Nutrition

2009-Present Antiviral Therapy

2009-Present Circulation

2009-Present Circulation Research

2010-Present Circulation Cardiovascular Imaging

2015-Present Circulation Cardiovascular Interventions

2015-Present JACC Cardiovascular Imaging

2017-Present JACC Cardiovascular Interventions

2017-Present JACC

GRANT REVIEWER

2010-Present Technology Foundation STW, The Netherlands,

2014-Present Wellcome Trust Foundation, Great Britain


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PUBLICATIONS

A. ARTICLES PUBLISHED IN SCHOLARLY JOURNALS

1. Baibhav B, Gedela M, Moutlon M, Pavlides G, Pompili V, Rab T, Dangas G, Bhatt D,

Siddique A, Chatzizisis YS. Role of Invasive Functional Assessment in Surgical

Revascularization of Coronary Artery Disease. Circulation. 2018, In press.

2. Gutiérrez-Chico, JL, Zhao S, Chatzizisis YS. Vorticity: At the Crossroads of Coronary

Biomechanics and Physiology. Atherosclerosis 2018, In press.

3. Karagiannis AD, Liu M, Toth PP, Zhao S, Agrawal DK, Libby P, Chatzizisis YS.

Pleiotropic Anti-atherosclerotic Effects of PCSK9 InhibitorsFrom Molecular Biology to

Clinical Translation. Curr Atheroscler Rep. 2018, In press.

4. Giannopoulos AA, Zhao S, Chatzizisis YS. Rupture of a stenotic thin-cap fibroatheroma in

an area of low endothelial shear stress: Implication for mechanism of acute coronary

syndromes. Eur Heart J Cardiovasc Imaging. 2018, In press.

5. Chatzizisis YS, Stefanadis C. Clash of Oral P2Y(12) Receptor Inhibitors in Acute Coronary

Syndromes. J Am Coll Cardiol. 2018;71:382-385

6. Asawaeer M, Sayyed S, Chatzizisis YS. A rare case of granulomatosis with polyangiitis-

induced burnout cardiomyopathy: role of combined viability and metabolic imaging. Eur

Heart J Cardiovasc Imaging. 2018, In press

7. Malik SA, Brilakis ES, Pompili V, Chatzizisis YS. Lost and found: Coronary stent retrieval

and review of literature. Catheter Cardiovasc Interv. 2018, In press.

8. Giannopoulos AA, Giannoglou GD, Chatzizisis YS. Predicting Coronary Atherosclerotic

Plaque Burden From Clinical Parameters: Bringing Old Knowledge in the Game. Angiology.

2018, In press.

9. Ormiston JA, Kassab G, Finet G, Chatzizisis YS, Foin N, Mickley TJ, Chiastra C, Murasato

Y, Hikichi Y, Wentzel JJ, Darremont O, Iwasaki K, Lefèvre T, Louvard Y, Beier S,

Hojeibane H, Netravali A, Wooton J, Cowan B, Webster MW, Medrano-Gracia P, Stankovic

G. Bench Testing and Coronary Artery Bifurcations: A Consensus Document from the

European Bifurcation Club. EuroIntervention. 2018;13:e1794-1803.

10. Kishi S, Giannopoulos AA, Tang A, Kato N, Chatzizisis YS, Dennie C, Horiuchi Y, Tanabe

K, Lima JAC, Rybicki FJ, Mitsouras D. Fractional Flow Reserve Estimated at Coronary CT

Angiography in Intermediate Lesions: Comparison of Diagnostic Accuracy of Different

Methods to Determine Coronary Flow Distribution. Radiology. 2018;287:76-84.


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11. Selim A, Zolty R, Chatzizisis YS. The evolution of heart failure with reduced ejection

fraction pharmacotherapy: What do we have and where are we going? Pharmacol Ther.

2017;178:67-82.

12. Shah NR, Cheezum MK, Motoyama S, Chatzizisis YS. Do we really need another individual

coronary plaque characterization measurement? Atherosclerosis. 2017;261:160-162.

13. Selim A, Zolty R, Chatzizisis YS. New heart failure pharmacotherapy in clinical trials: a

hope in progress. Expert Rev Cardiovasc Ther. 2017;15:649-651.

14. Cheimariotis GA, Chatzizisis YS, Koutkias VG, Toutouzas K, Giannopoulos A, Riga M,

Chouvarda I, Antoniadis AP, Doulaverakis C, Tsamboulatidis I, Kompatsiaris I, Giannoglou

GD, Maglaveras N. ARCOCT: Automatic detection of lumen border in intravascular OCT

images. Comput Methods Programs Biomed. 2017;151:21-32.

15. Malik SA, Porter TT, Pavlides G, Chatzizisis Y. Vasospastic Angina Presenting With

Syncope and Chest Pain: A Case Report and Brief Literature Review. S D Med.

2017;70:498-502.

16. Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira

M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK,

Nahrendorf M, Aikawa E, Croce K, Libby P. Flow Perturbation Mediates Neutrophil

Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for

Superficial Erosion. Circ Res. 2017;121:31-42.

17. Giannopoulos AA, Mitsouras D, Yoo SJ, Liu PP, Chatzizisis YS, Rybicki FJ. Applications

of 3D printing in cardiovascular diseases. Nat Rev Cardiol. 2016;13:701-718.

18. Huang D, Muramatsu T, Li Y, Yang W, Nagahara Y, Chu M, Kitslaar P, Sarai M, Ozaki Y,

Chatzizisis YS, Yan F, Reiber JH, Wu R, Pu J, Tu S. Assessment of endothelial shear stress

in patients with mild or intermediate coronary stenoses using coronary computed tomography

angiography: comparison with invasive coronary angiography. Int J Cardiovasc Imaging.

2017;33:1101-1110

19. Antoniadis AP, Papafaklis MI, Takahashi S, Shishido K, Andreou I, Chatzizisis YS, Tsuda

M, Mizuno S, Makita Y, Domei T, Ikemoto T, Coskun AU, Honye J, Nakamura S, Saito S,

Edelman ER, Feldman CL, Stone PH. Arterial Remodeling and Endothelial Shear Stress

Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques.

JACC Cardiovasc Imaging. 2016;9:1007-9

20. Chatzizisis YS, Toutouzas K, Giannopoulos AA, Riga M, Antoniadis AP, Fujinom Y,

Mitsouras D, Koutkias VG, Cheimariotis G, Doulaverakis C, Tsampoulatidis I, Chouvarda I,

Kompatsiaris I, Nakamura S, Rybicki FJ, Maglaveras N, Tousoulis D, Giannoglou GD.

Association of global and local low endothelial shear stress with high-risk plaque using

intracoronary 3D optical coherence tomography: Introduction of 'shear stress score'. Eur

Heart J Cardiovasc Imaging. 2017;18:888-897


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21. Gitsioudis G*, Chatzizisis YS*, Wolf P, Missiou A, Antoniadis AP, Mitsouras D, Bartling

S, Arica Z, Stuber M, Rybicki FJ, Nunninger M, Erbel C, Libby P, Giannoglou GD, Katus

HA, Korosoglou G. Combined non-invasive assessment of endothelial shear stress and

molecular imaging of inflammation for the prediction of inflamed plaque in hyperlipidaemic

rabbit aortas. Eur Heart J Cardiovasc Imaging. 2017;187:19-30

22. Giannoglou GD, Giannopoulos AA, Chatzizisis YS. Lowering Heart Rate Post

Revascularization: Angina and Quality of Life Improvement. Angiology. 2017;68:5-7

23. Tsigkas N, Kidambi S, Tawakol A, Chatzizisis YS. Drug-loaded particles: "Trojan horses"

in the therapy of atherosclerosis. Atherosclerosis. 2016;251:528-30.

24. Giannopoulos AA, Chatzizisis YS, Maurovich-Horvat P, Antoniadis AP, Hoffmann U,

Steigner ML, Rybicki FJ, Mitsouras D. Quantifying the effect of side branches in endothelial

shear stress estimates. Atherosclerosis. 2016;251:213-8.

25. Carreras ET, Chatzizisis YS, Mauri L, MacRae C. Acute Coronary Syndrome in a 52-Year-

Old Woman With Scleroderma. Circulation. 2016;133:2576-82.

26. Giannopoulos AA, Giannoglou GD, Chatzizisis YS. Refractory angina: new drugs on the

block. Expert Rev Cardiovasc Ther. 2016;14:881-3.

27. Giannopoulos AA, Antoniadis AP, Croce K, Chatzizisis YS. Erosion of Thin-Cap

Fibroatheroma in an Area of Low Endothelial Shear Stress: Anatomy and Local

Hemodynamic Environment Dictate Outcomes. JACC Cardiovasc Interv. 2016;9:e77-8.

28. Giannopoulos AA, Giannoglou GD, Chatzizisis YS. Pharmacological approaches of

refractory angina. Pharmacol Ther. 2016;163:118-31.

29. George E, Giannopoulos AA, Aghayev A, Rohatgi S, Imanzadeh A, Antoniadis AP,

Kumamaru KK, Chatzizisis YS, Dunne R, Steigner M, Hanley M, Gravereaux EC, Rybicki

FJ, Mitsouras D. Contrast inhomogeneity in CT angiography of the abdominal aortic

aneurysm. J Cardiovasc Comput Tomogr. 2016;10:179-83.

30. Antoniadis AP, Stone PH, Chatzizisis YS. Foretelling plaque disruption: Is the journey to

Ithaca reaching destination? Atherosclerosis. 2016;244:147-8.

31. Vergallo R, Aguirre AD, Abtahian F, Minami Y, Soeda T, Chatzizisis YS, Croce K, Jang

IK. Recurrent myocardial infarctions and premature coronary atherosclerosis in a 23-year-old

man with antiphospholipid syndrome. Thromb Haemost. 2016;115:237-9.

32. Antoniadis AP, Papafaklis MI, Takahashi S, Shishido K, Andreou I, Chatzizisis YS, Tsuda

M, Mizuno S, Makita Y, Domei T, Ikemoto T, Coskun AU, Honye J, Nakamura S, Saito S,

Edelman ER, Feldman CL, Stone PH. The Longitudinal Heterogeneity of Remodeling and


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Endothelial Shear Stress along the Length of Plaque Determines the Topography and Natural

History of Coronary Artery Disease in Humans. JACC Cardiovasc Imaging 2016;9:1007-9.

33. Toutouzas K, Benetos G, Karanasos A, Chatzizisis YS, Giannopoulos AA, Tousoulis D.

Vulnerable plaque imaging: updates on new pathobiological mechanisms. Eur Heart J.

2015;36:3147-54.

34. Antoniadis AP, Mortier P, Kassab G, Dubini G, Foin N, Murasato Y, Giannopoulos AA, Tu

S, Iwasaki K, Hikichi Y, Migliavacca F, Chiastra C, Wentzel JJ, Gijsen F, Reiber JH, Barlis

P, Serruys PW, Bhatt DL, Stankovic G, Edelman ER, Giannoglou GD, Louvard Y,

Chatzizisis YS. Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting:

Expert Review Document on Techniques and Clinical Implementation. JACC Cardiovasc

Interv. 2015;8:1281-96.

35. Dakos G, Konstantinou D, Chatzizisis YS, Chouvarda I, Filos D, Paraskevaidis S, Mantziari

L, Maglaveras N, Karvounis H, Vassilikos V. P wave analysis with wavelets identifies

hypertensive patients at risk of recurrence of atrial fibrillation: A case-control study and

1year follow-up. J Electrocardiol. 2015;48:845-52.

36. Mavrakanas TA, Chatzizisis YS. Bivalirudin in ST-segment-elevation myocardial infarction:

for better or worse? Expert Rev Cardiovasc Ther. 2015;13:893-5.

37. Ferencik M, Chatzizisis YS. Statins and the coronary plaque calcium "paradox": Insights

from non-invasive and invasive imaging. Atherosclerosis. 2015;241:783-5.

38. Migliavacca F, Chiastra C, Chatzizisis YS, Dubini G. Virtual bench testing to study

coronary bifurcation stenting. EuroIntervention. 2015;11 Suppl V:V31-4.

39. Antoniadis AP, Giannopoulos AA, Wentzel JJ, Joner M, Giannoglou GD, Virmani R,

Chatzizisis YS. Impact of local flow haemodynamics on atherosclerosis in coronary artery

bifurcations. EuroIntervention. 2015 May;11 Suppl V:V18-22.

40. Giannopoulos AA, Antoniadis AP, Croce KJ, Chatzizisis YS. Advanced anatomical and

functional imaging guides management of coronary artery ulcerated plaque. Eur Heart J

Cardiovasc Imaging. 2015;16:1042.

41. Toutouzas K, Chatzizisis YS, Riga M, Giannopoulos A, Antoniadis AP, Tu S, Fujino Y,

Mitsouras D, Doulaverakis C, Tsampoulatidis I, Koutkias VG, Bouki K, Li Y, Chouvarda I,

Cheimariotis G, Maglaveras N, Kompatsiaris I, Nakamura S, Reiber JH, Rybicki F,

Karvounis H, Stefanadis C, Tousoulis D, Giannoglou GD. Accurate and reproducible

reconstruction of coronary arteries and endothelial shear stress calculation using 3D OCT:

comparative study to 3D IVUS and 3D QCA. Atherosclerosis. 2015;240:510-9.

42. Saboo SS, Abbara S, Rybicki FJ, Chatzizisis YS. Quantification of aortic calcification - how

and why should we do it? Atherosclerosis. 2015;240:469-71.


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43. Mavrakanas TA, Chatzizisis YS. Bivalirudin in stable angina and acute coronary syndromes.

Pharmacol Ther. 2015;152:1-10.

44. Juan YH, Chatzizisis YS, Saboo SS, Rocha T, Steigner ML. Tumor encasement of the right

coronary artery: role of anatomic and functional imaging in diagnosis and therapeutic

management. Open Cardiovasc Med J. 2014;8:110-2.

45. Andreou I, Antoniadis AP, Shishido K, Papafaklis MI, Koskinas KC, Chatzizisis YS,

Coskun AU, Edelman ER, Feldman CL, Stone PH. How do we prevent the vulnerable

atherosclerotic plaque from rupturing? Insights from in vivo assessments of plaque, vascular

remodeling, and local endothelial shear stress. J Cardiovasc Pharmacol Ther.

2015;20:261-75.

46. Hucker WJ, Chatzizisis YS, Steigner ML, Winters GL, Kirshenbaum JM. Myocardial

catastrophe: a case of sudden, severe myocardial dysfunction. Circulation. 2014;130:854-

62.

47. Chatzizisis YS, Antoniadis AP, Wentzel JJ, Giannoglou GD. Vulnerable plaque: the

biomechanics of matter. Atherosclerosis. 2014;236:351-2.

48. Chatzizisis YS, George E, Cai T, Fulwadhva UP, Kumamaru KK, Schultz K, Fujisawa Y,

Rassi C, Steigner M, Mather RT, Blankstein R, Rybicki FJ, Mitsouras D. Accuracy and

reproducibility of automated, standardized coronary transluminal attenuation gradient

measurements. Int J Cardiovasc Imaging. 2014;30:1181-9.

49. Giannoglou GD, Chatzizisis YS. Heart rate lowering reduces cardiovascular disease burden.

Curr Med Res Opin. 2014;30:1757.

50. Chatzizisis YS, Blankstein R, Libby P. Inflammation goes with the flow: Implications for

non-invasive identification of high-risk plaque. Atherosclerosis. 2014;234:476-8.

51. Dakos G*, Chatzizisis YS*, Konstantinou D, Chouvarda I, Filos D, Paraskevaidis S,

Mantziari L, Maglaveras N, Karvounis H, Styliadis I, Vassilikos V. Wavelet-based analysis

of P waves identifies patients with lone atrial fibrillation: A cross-sectional pilot study. Int J

Cardiol. 2014;174:389-92.

52. Chatzizisis YS, Koutkias VG, Toutouzas K, Giannopoulos A, Chouvarda I, Riga M,

Antoniadis AP, Cheimariotis G, Doulaverakis C, Tsampoulatidis I, Bouki K, Kompatsiaris I,

Stefanadis C, Maglaveras N, Giannoglou GD. Clinical validation of an algorithm for rapid

and accurate automated segmentation of intracoronary optical coherence tomography images.

Int J Cardiol. 2014;172:568-80.

53. Juan YH, Chatzizisis YS, Saboo SS, Newburger JW, Steigner ML. Hypoplastic left coronary

artery with large collateral vessels from an ectatic right coronary artery: Multimodality

imaging-based diagnostic work-up. Int J Cardiol. 2014;15:185-7


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54. Waller AH, Chatzizisis YS, Moslehi JJ, Chen FY, Mangion JR. Real-time three-dimensional

transoesophageal echocardiography enables preoperative pulmonary valvulopathy

assessment. Eur Heart J Cardiovasc Imaging 2014;15:713.

55. Ghosh N, Waller AH, Rinehart E, Lakdawala NK, Chatzizisis YS, Padera R, Couper G,

Mangion J, Steigner M. Multimodality imaging for the assessment of total artificial heart

function: complementary utility of 2- and 3-dimensional transesophageal echocardiography

and computed tomography. J Am Coll Cardiol. 2014;63:e7.

56. Doulaverakis C, Tsampoulatidis I, Antoniadis AP, Chatzizisis YS, Giannopoulos A,

Kompatsiaris I, Giannoglou GD. IVUSAngio tool: a publicly available software for fast and

accurate 3D reconstruction of coronary arteries. Comput Biol Med. 2013;43:1793-803.

57. Koskinas KC*, Chatzizisis YS*, Papafaklis MI, Coskun AU, Baker AB, Jarolim P,

Antoniadis A, Edelman ER, Stone PH, Feldman CL. Synergistic effect of local endothelial

shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque

progression and composition in pigs. Int J Cardiol. 2013;169:394-401.

58. Gutierrez A, Chatzizisis YS, Rao SV. Progression of radial approach to PCI in the USA:

from niche procedure to default approach. Expert Rev Cardiovasc Ther. 2013;11:1271-3.

59. Paraskevaidis S, Theofilogiannakos EK, Kamperidis V, Chatzizisis YS, Tsilonis K,

Vassilikos VP, Dakos G, Stavropoulos G, Ziakas A, Hadjimiltiades S, Styliadis IH.

Quinidine: an "endangered species" drug appropriate for management of electrical storm in

brugada syndrome. Indian Pacing Electrophysiol J. 2013;13:178-80.

60. Chatzizisis YS, Murthy VL, Solomon SD. Echocardiographic evaluation of coronary artery

disease. Coron Artery Dis. 2013;24:613-23.

61. Vassilikos VP, Mantziari L, Dakos G, Kamperidis V, Chouvarda I, Chatzizisis YS, Kalpidis

P, Theofilogiannakos E, Paraskevaidis S, Karvounis H, Mochlas S, Maglaveras N, Styliadis

IH. QRS analysis using wavelet transformation for the prediction of response to cardiac

resynchronization therapy: a prospective pilot

study. J Electrocardiol. 2014;47:59-65.

62. Katranas SA, Kelekis AL, Antoniadis AP, Chatzizisis YS, Giannoglou GD. Association of

Remodeling With Endothelial Shear Stress, Plaque Elasticity, and Volume in Coronary

Arteries: A Pilot Coronary Computed Tomography Angiography Study. Angiology.

2014;65:413-9

63. Chatzizisis YS, Ziakas A, Feloukidis C, Paramythiotis D, Hadjimiltiades S, Iliadis A,

Basdanis G, Styliadis I. Pheochromocytoma crisis presenting with cardiogenic shock. Herz.

2014;39:156-60


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64. Saboo SS, Chatzizisis YS, Khandelwal A, Blankstein R. Acute coronary syndrome

unmasking a puzzling coronary anatomy: role of multimodality anatomic and functional

imaging. Eur Heart J. 2013;34:3089.

65. Koskinas KC*, Sukhova GK*, Baker AB*, Papafaklis MI*, Chatzizisis YS*, Coskun AU,

Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi GP, Libby P, Edelman ER, Feldman

CL, Stone PH. Thin-Capped Atheromata With Reduced Collagen Content in Pigs Develop in

Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress.

Arterioscler Thromb Vasc Biol. 2013;33:1494-1504.

66. Koskinas KC*, Chatzizisis YS*, Antoniadis A, Giannoglou GD. Role of Endothelial shear

stress in stent restenosis and thrombosis. Pathophysiologic mechanisms and implications for

clinical translation. J Am Coll Cardiol 2012;59:1337-49.

67. Chatzizisis YS, Baker A, Sukhova GK, Koskinas K, Papafaklis M, Beigel R, Jonas M,

Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Edelman ER, Feldman CL, Stone PH.

Augmented expression and activity of extracellular matrix–degrading enzymes in regions of

low endothelial shear stress co-localize with coronary atheromata with thin fibrous caps in

pigs. Circulation 2011;123:621-30.

68. Koskinas KC, Feldman CL, Chatzizisis YS, Coskun AU, Jonas M, Maynard C, Baker A,

Papafaklis M, Edelman ER, Stone PH. Natural history of experimental coronary

atherosclerosis and vascular remodeling in relation to endothelial shear stress: A serial, in-

vivo intravascular ultrasound study. Circulation 2010;121:2092-101.

69. Chatzizisis YS, Jonas M, Coskun AU, Beigel R, Stone BV, Maynard C, Gerrity RG, Daley

W, Rogers C, Edelman ER, Feldman CL, Stone PH. Prediction of the localization of high-

risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an

intravascular ultrasound and histopathology natural history study. Circulation.

2008;117:993-1002.

70. Nelson KH, Chatzizisis YS, Steigner ML, Mitchell RN, Blankstein R, Givertz MM. Cardiac

Allograft Involvement by Post-transplant Lymphoproliferative Disorder. J Am Coll Cardiol

2013;62:937.

71. Konstantinou DM, Chatzizisis YS, Giannoglou GD. Heart failure with preserved ejection

fraction: future directions in medical treatment. Expert Rev Cardiovasc Ther.

2013;11:1085-7.

72. Konstantinou DM, Chatzizisis YS, Giannoglou GD. Pathophysiology-based novel

pharmacotherapy for heart failure with preserved ejection fraction. Pharmacol Ther.

2013;140:156-66.

73. Saboo SS, Chatzizisis YS, Khandelwal A, Bolman RM 3rd, Steigner M. Multimodality

imaging of aortic valve fibroelastoma. Eur Heart J Cardiovasc Imaging. 2013;14:834.


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74. Papafaklis MI, Chatzizisis YS, Naka KK, Giannoglou GD, Michalis LK. Drug-eluting stent

restenosis: Effect of drug type, release kinetics, hemodynamics and coating strategy.

Pharmacol Ther. 2012;134:43-53.

75. Wentzel JJ, Chatzizisis YS, Gijsen FJ, Giannoglou GD, Feldman CL, Stone PH. Endothelial

shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling:

current understanding and remaining questions. Cardiovasc Res. 2012;96:234-43.

76. Giannopoulos A, Chatzizisis YS, Giannoglou GD. Optical coherence tomography: an arrow

in our quiver. Expert Rev Cardiovasc Ther. 2012;10:539-41.

77. Giannoglou GD, Chatzizisis YS. Atherosclerosis: what are we looking for? Angiology.

2012;63:397-9.

78. Chatzizisis YS, Giannoglou GD. Importance of local hemodynamic conditions in the

atherosclerotic effect of increased heart rate. J Am Coll Cardiol. 2011;57:2206.

79. Katranas SA, Kelekis AL, Antoniadis AP, Chatzizisis YS, Theodoridis TF, Tzanis AP,

Giannoglou GD. Non-invasive assessment of endothelial shear stress and coronary stiffness

using multislice computed tomography. Int J Cardiol. 2011;20;152:281-4.

80. Vaklavas C, Chatzizisis YS, Tsimberidou AM. Common cardiovascular medications in

cancer therapeutics. Pharmacol Ther. 2011;130:177-90.

81. Vasilikos V, Dakos G, Chatzizisis YS, Chouvarda I, Karvounis C, Maynard C, Maglaveras

N, Styliadis, Paraskevaidis S, Mochlas S, Styliadis I. Novel non-invasive P wave analysis for

the prediction of paroxysmal atrial fibrillation recurrences in patients without heart disease:

A prospective pilot study. Int J Cardiol 2011;153:165-72.

82. Mantziari AA, Vassilikos VP, Chatzizisis YS, Dakos G, Stavropoulos G, Paraskevaidis S,

Styliadis IH. Cardiac arrest caused by torsades de pointes tachycardia after successful atrial

flutter radiofrequency catheter ablation. Open Cardiovasc Med J. 2011;5:1-3.

83. Konstantinou DM, Chatzizisis YS, Farmakis G, Styliadis I, Giannoglou GD. Cholesterol

embolization syndrome following thrombolysis during acute myocardial infarction. Herz.

2011;37:231-3.

84. Vaklavas C, Chatzizisis YS. The changing perspective of cardiology in cancer care. Expert

Rev Cardiovasc Ther 2011;9:1-3.

85. Paraskevaidis S, Kamperidis V, Theofilogiannakos E, Chatzizisis YS, Stavropoulos G,

Vassilikos V, Dakos G, Gavrielidis S, Styliadis I. Brugada syndrome associated with

supraventricular tachycardia: Diagnostic and therapeutic strategy. Herz 2011;36:724-7.


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86. Koskinas KC, Chatzizisis YS, Kamperidis V, Anastasiadis Κ, Zioga C, Hadjimiltiades S,

Giannoglou GD. Extremely rare case of primary cardiac chondroma in a patient presenting

with acute pulmonary edema. Cardiovasc Pathol 2011;20:374-6.

87. Giannoglou GD, Antoniadis AP, Koskinas KC, Chatzizisis YS. Flow and atherosclerosis in

coronary bifurcations. EuroIntervention. 2010;6 Suppl J:J16-23.

88. Papafaklis MI, Koskinas KC, Chatzizisis YS, Stone PH, Feldman CL. In vivo assessment of

the natural history of coronary atherosclerosis: vascular remodeling and endothelial shear

stress determine the complexity of atherosclerotic disease progression. Curr Opin Cardiol

2010;25:627-38

89. Baker AB*, Chatzizisis YS*, Beigel R, Jonas M, Stone BV, Coskun AU, Maynard C,

Campbell R, Feldman CL, Stone PH, Edelman ER. Regulation of heparanase expression in

coronary artery disease in diabetic hyperlipidemic swine. Atherosclerosis 2010;213:436-42

90. Chatzizisis YS, Jonas M, Beigel R, Coskun AU, Baker AB, Stone BV, Maynard C, Gerrity

RG, Daley W, Edelman ER, Feldman CL, Stone PH. Attenuation of inflammation and

expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk

coronary atherosclerotic plaques. Atherosclerosis. 2009;203:387-94.

91. Koskinas KC, Chatzizisis YS, Baker AB, Edelman ER, Stone PH, Feldman CL. The role of

low endothelial shear stress in the conversion of atherosclerotic lesions from stable to

unstable plaque. Curr Opin Cardiol. 2009;24:580-90.

92. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Stone PH, Feldman CL. Risk

stratification of individual coronary lesions using local endothelial shear stress: a new

paradigm for managing coronary artery disease. Curr Opin Cardiol. 2007;22:552-64.

93. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Louridas GE. Difference in the topography

of atherosclerosis in the left versus right coronary artery in patients referred for coronary

angiography. BMC Cardiovasc Disord 2010;10:26.

94. Chatzizisis YS, Giannoglou GD. Shear Stress and Inflammation: Are we getting closer to the

prediction of vulnerable plaque? Expert Rev Cardiovasc Ther 2010;8:1351-3.

95. Kontantinou DM, Chatzizisis YS, Louridas GE, Parcharidis GE, Giannoglou GD. Non-

diabetic hyperglycemia correlates with angiographic coronary artery disease prevalence and

severity. Diabetes Metab 2010;36:402-8.

96. Chatzizisis YS, Koskinas K, Misirli G, Vaklavas C, Hatzitolios A, Giannoglou G. Risk

factors and drug interactions predisposing to statin-induced myopathy: Implications for risk

assessment, prevention and treatment. Drug Saf 2010;32:1-17.

97. Katsiki N, Tziomalos K, Chatzizisis Y, Elisaf M, Hatzitolios AI. Effect of HMG-CoA

reductase inhibitors on vascular cell apoptosis: Beneficial or detrimental? Atherosclerosis


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2010;211:9-14.

98. Giannoglou GD, Konstantinou DM, Kovatsi L, Chatzizisis YS, Louridas GD. Association of

reduced zinc status with angiographically severe coronary atherosclerosis. A pilot study.

Angiology 2010;61:449-55.

99. Konstantinou DM, Chatzizisis YS, Louridas GE, Giannoglou GD. Metabolic syndrome and

angiographic coronary artery disease prevalence in association with Framingham risk score.

Metab Syndr Relat Disord 2010;8:201-8.

100. Chatzizisis YS, Saravakos P, Boufidou A, Parharidou D, Styliadis I. Acute myocardial

infarction manifested with headache. Open Cardiovasc Med J 2010;4;148-150.

101. Paraskevaidis S, Theofilogiannakos EK, Chatzizisis YS, Mantziari A, Economou F, Ziakas

A, Hadjimiltiades S, Styliadis IH. Spontaneous dissection of a right coronary artery

manifested with acute myocardial infarction. Open Cardiovasc Med J 2010;4:178-80.

102. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Louridas GE. Adult congenital heart

disease investigated with cardiac catheterization over a 20-year period. Open Cardiovasc

Med J. 2009;3:124-7.

103. Vaklavas C, Chatzizisis YS, Ziakas A, Zamboulis C, Giannoglou GD. Molecular basis of

statin-associated myopathy. Atherosclerosis. 2009;202:18-28.

104. Paraskevaidis S, Stavropoulos G, Vassilikos V, Chatzizisis YS, Polymeropoulos K, Ziakas

A, Dakos G, Parcharidis GE. Idiopathic left ventricular aneurysm causing ventricular

tachycardia with 1:1 ventriculoatrial conduction and intermittent wenckebach block. Open

Cardiovasc Med J. 2009;3:105-9.

105. Chatzizisis YS, Giannoglou GD. Myocardial bridges spared from atherosclerosis: overview

of the underlying mechanisms. Can J Cardiol. 2009;25:219-22.

106. Chatzizisis YS, Vaklavas C, Giannoglou GD. Coenzyme Q10 depletion: etiopathogenic or

predisposing factor in statin associated myopathy? Am J Cardiol. 2008;101:1071.

107. Chatzizisis YS, Misirli G, Hatzitolios AI, Giannoglou GD. The syndrome of

rhabdomyolysis: complications and treatment. Eur J Intern Med. 2008;19:568-74.

108. Antoniadis AP, Chatzizisis YS, Giannoglou GD. Pathogenetic mechanisms of coronary

ectasia. Int J Cardiol. 2008;130:335-43.

109. Papadogiorgaki M, Mezaris V, Chatzizisis YS, Giannoglou GD, Kompatsiaris I. Image

analysis techniques for automated IVUS contour detection. Ultrasound Med Biol.

2008;34:1482-98.

110. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Damvopoulou E, Parcharidis GE, Louridas


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GE. Sex-related differences in the angiographic results of 14,500 cases referred for suspected

coronary artery disease. Coron Artery Dis. 2008;19:9-14.

111. Chatzizisis YS, Giannoglou GD, Sianos G, Ziakas A, Tsikaderis D, Dardas P, Matakos A,

Basdekidou C, Misirli G, Zamboulis C, Louridas GE, Parcharidis GE. In vivo comparative

study of linear versus geometrically correct three-dimensional reconstruction of coronary

arteries. Am J Cardiol. 2008;101:263-7.

112. Giannoglou GD, Chatzizisis YS, Zamboulis C, Parcharidis GE, Mikhailidis DP, Louridas

GE. Elevated heart rate and atherosclerosis: an overview of the pathogenetic mechanisms. Int

J Cardiol. 2008;126:302-12.

113. Soulis JV, Giannoglou GD, Chatzizisis YS, Seralidou KV, Parcharidis GE, Louridas GE.

Non-Newtonian models for molecular viscosity and wall shear stress in a 3D reconstructed

human left coronary artery. Med Eng Phys. 2008;30:9-19.

114. Chatzizisis Y. Ask the doctor. Why don't you ever tell your readers that everyone who takes

a statin to lower cholesterol should be taking coenzyme Q(10) too? Harv Heart Lett.

2008;19:8.

115. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of

endothelial shear stress in the natural history of coronary atherosclerosis and vascular

remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007;49:2379-

93.

116. Chatzizisis YS, Giannoglou GD, Parcharidis GE, Louridas GE. Is left coronary system more

susceptible to atherosclerosis than right? A pathophysiological insight. Int J Cardiol.

2007;116:7-13

117. Chatzizisis YS, Giannoglou GD. Coronary hemodynamics and atherosclerotic wall stiffness:

a vicious cycle. Med Hypotheses. 2007;69:349-55.

118. Giannoglou GD, Chatzizisis YS, Misirli G. The syndrome of rhabdomyolysis:

Pathophysiology and diagnosis. Eur J Intern Med. 2007;18:90-100.

119. Giannoglou GD, Chatzizisis YS, Koutkias V, Kompatsiaris I, Papadogiorgaki M, Mezaris V,

Parissi E, Diamantopoulos P, Strintzis MG, Maglaveras N, Parcharidis GE, Louridas GE. A

novel active contour model for fully automated segmentation of intravascular ultrasound

images: in vivo validation in human coronary arteries. Comput Biol Med. 2007;37:1292-

302.

120. Chatzizisis Y, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Reply to the

letter to the Editor by H. Kaneda. J Am Coll Cardiol 2007;50:2171-2.

121. Giannoglou GD, Chatzizisis YS, Sianos G, Tsikaderis D, Matakos A, Koutkias V,

Diamantopoulos P, Maglaveras N, Parcharidis GE, Louridas GE. Integration of multi-


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modality imaging for accurate 3D reconstruction of human coronary arteries in vivo. Nucl

Instr Meth Phys Res A. 2006;569:310-3.

122. Papadogiorgaki M, Mezaris V, Chatzizisis YS, Giannoglou GD, Kompatsiaris I. Texture

Analysis and Radial Basis Function Approximation for IVUS Image Segmentation. Open

Biomed Eng J. 2007;1:53-9.


GE. Prevalence of narrowing >or=50% of the left main coronary artery among 17,300

patients having coronary angiography. Am J Cardiol. 2006;98:1202-5.

124. Giannoglou G, Giannakoulas G, Soulis J, Chatzizisis Y, Perdikides T, Melas N, Parcharidis

G, Louridas G. Predicting the risk of rupture of abdominal aortic aneurysms by utilizing

various geometrical parameters: revisiting the diameter criterion. Angiology. 2006;57:487-

94.

125. Chatzizisis YS, Giannoglou GD, Matakos A, Basdekidou C, Sianos G, Panagiotou A,

Dimakis C, Parcharidis GE, Louridas GE. In-vivo accuracy of geometrically correct three-

dimensional reconstruction of human coronary arteries: is it influenced by certain

parameters? Coron Artery Dis. 2006;17:545-51.

126. Giannoglou GD, Chatzizisis YS, Sianos G, Tsikaderis D, Matakos A, Koutkias V,

Diamantopoulos P, Maglaveras N, Parcharidis GE, Louridas GE. In-vivo validation of

spatially correct three-dimensional reconstruction of human coronary arteries by integrating

intravascular ultrasound and biplane angiography. Coron Artery Dis. 2006;17:533-43.


GE. Prevalence of ectasia in human coronary arteries in patients in northern Greece referred

for coronary angiography. Am J Cardiol. 2006;98:314-8.

128. Soulis JV, Giannoglou GD, Chatzizisis YS, Farmakis TM, Giannakoulas GA, Parcharidis

GE, Louridas GE. Spatial and phasic oscillation of non-Newtonian wall shear stress in human

left coronary artery bifurcation: an insight to atherogenesis. Coron Artery Dis. 2006;17:351-

8.

129. Chatzizisis YS, Giannoglou GD. Pulsatile flow: a critical modulator of the natural history of

atherosclerosis. Med Hypotheses. 2006;67:338-40.

130. Tzavella K, Chatzizisis YS, Vakali A, Mandraveli K, Zioutas D,Alexiou-Daniel S. Severe

case of Mediterranean spotted fever in Greece with predominantly neurological features. J

Med Microbiol. 2006;55:341-3.

131. Soulis JV, Farmakis TM, Giannoglou GD, Chatzizisis YS, Giannakoulas GA, Parcharidis

GE, Louridas GE. Molecular viscosity in the normal left coronary arterial tree. Is it related to

atherosclerosis? Angiology. 2006;57:33-40.


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C. ARTICLES SUBMITTED FOR PUBLICATION IN SCHOLARLY JOURNALS

1. Chatzizisis YS, Watanabe Y, Murasato Y, Karagiannis A, Asawaeer M, Zhao S, Shinke T,

Wooten S, Lefevre T, Nagoshi R, Nozaki Y, Masuda N, Okamura, T, Numasawa, Y, Takagi

K, Chiastra C, Dubini G, Burzotta F, Samady H, Stankovic G, Kozuma K, Louvard Y,

Kassab G. Effect of Local Biomechanical Factors on Bifurcation Stent Restenosis and

Thrombosis: Rationale and Design of a multi-center, prospective, randomized Flow ISR

Study. Submitted, BMJ Open.

2. Mavrakanas TA, Chatzizisis YS, Gariani K, Kereiakes DJ, Gargiulo G, Helft G, Gilard M,

Morice MC, Georges JL, Valgimigli M, Bhatt DL, Mauri L, Charytan DM. Duration of dual

antiplatelet therapy in patients with chronic kidney disease and drug-eluting stents: a meta-

analysis. Submitted, J Am Soc Nephrol.

D. CHAPTERS IN BOOKS

1. Parissi, E, Kompatsiaris, Y, Chatzizisis YS, Koutkias V, Magalveras N, Strintzis MG,

Giannoglou GD. Lecture Notes in Bioinformatics. Berlin Heidelberg, Germany: Springer-

Verlag; 2006. An automated model for rapid and reliable segmentation of intravascular

ultrasound images; 368-377.

2. Chatzizisis YS, Papadogiorgaki M, Mezaris, V, Giannoglou GD, Kompatsiaris I.

Encyclopedia of Information Science and Technology. 2nd. VIII. IGI Global; 2008. Visual

Medical Information Analysis; 4034-40.

3. Feldman CL, Chatzizisis YS, Coskun AU, Koskinas KC, Naghavi M, Stone PH. Vulnerable

Anatomy: The Role of Coronary Anatomy and Endothelial Shear Stress in the Progression

and Vulnerability of Coronary Artery Lesions: Is Anatomy Destiny? Humana Press; 2010.

Asymptomatic Atherosclerosis: Pathophysiology, Detection and treatment.

4. Giannoglou, GD, Chatzizisis YS. Future Trends in Intravascular Imaging. IGI Global; 2011.

Intravascular Imaging: Current Applications and Research Developments; 350-354.

COMMITTEES

Local

1. Member, Cardiac arrest subcommittee, UNMC

2. Member, Mortality review committee, UNMC

International

Conference organizing

committee member

George D. Behrakis Cardiovascular Symposium on Vascular Biology

November 2014, Brigham and Women’s Hospital, Harvard Medical

School, Boston, USA


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Round table chair Session: How to evaluate stents and techniques for bifurcation

stenting? 8th European Bifurcation Club Meeting, October 12-13,

2012, Barcelona, Spain

Poster moderator Poster Group 1: Endothelium and atherothrombosis

81st European Atherosclerosis Society Congress. June 2-5, 2013,

Lyon, France

COMPUTER SKILLS

Microsoft Windows 8.0

OSX 10.9 (Mac)

Microsoft Office (Word, Excel, PowerPoint, Outlook, Access)

iWorks (Pages, Numbers, Keynote)

Statistical software: SPSS, GraphPad Prism, STATA, MedCalc

Computer-aided design software: Rhinoceros, MIMICS, CorelDraw, iDraw

Mathematical software: Matlab

Computational fluid dynamics (CFD) software: ANSYS, Fluent

LANGUAGES

Fluent in English

Fluent in Greek

HOBBIES AND INTERESTS

Soccer

Formula 1

Photography

Ancient Greek Literature

curriculum vitae yiannis s. chatzizisis, md, phd, facc, … · 2018. 9. 30. · yiannis s....

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