curriculum vitae - temple universitycurriculum vitae _____ page 1 mahmut safak, ph.d. business...

CURRICULUM VITAE

_______________________________________________________________________________________________________________________________________________________________

MAHMUT SAFAK, Ph.D.

BUSINESS ADDRESS: Department of Neuroscience, MERB-757

Temple University School of Medicine

3500 N. Broad Street

Philadelphia, PA 19140

BUSSINESS TELEPHONE: (215) 707-6338

BIRTH PLACE: Ankara, TURKEY

CITIZENSHIP STATUS: USA Citizen

EDUCATION AND TRAINING

UNDERGRADUATE SCHOOL DATES DEGREE/YR/SUBJECT

MONTH/YEAR

Ankara University

Ankara, TURKEY Sept, 1980-June 1983 BS,1983, Biology

GRADUATE/PROFESSIONAL SHOOL

West Chester University

West Chester, PA, USA Jan, 1985-May 1992 MS, 1992, Biology

Thomas Jefferson University

Philadelphia PA, USA Sept. 1993-May 1999 Ph.D, 1999, Biochemistry

& Molecular Biology

GRADUATE/PROFESSIONAL SHOOL

West Chester University

West Chester, PA, USA Jan, 1985-May 1992 MS, 1992, Biology

Signed:_________________Mahmut Safak_________Dated:_____September 16, 2011_____________

Thomas Jefferson University

Philadelphia PA, USA Sept. 1993-May 1999 Ph.D, 1999, Biochemistry

& Molecular Biology

POSTDOCTORAL FELLOWSHIP TRAINING

Laboratory of Dr. Kamel Khalili,

Center for Neurovirology and Neurooncology,

MCP-Hahneman University,

Philadelphia, PA, USA

Characterization of functional interaction between

two cellular proteins, Pur and YB-1, and their involvement

in JC virus gene regulation May 1999-Nov 2000

Laboratory of Dr. Kamel Khalili,

Center for Neurovirology and Cancer Biology,

Temple University, Philadelphia, PA USA.

Investigation of JCV late Agnoprotein function in JCV

gene transcription and replication through its functional

interaction with viral early regulatory protein, large T antigen. Nov 2000-Apr. 2002

ACADEMIC HONORS, SCHOLARSHIPS AND AWARDS

Graduate Fellowship, Thomas Jefferson University Sept, 1993-May 1999

Post-Graduate Merit Scholarship Ministry of National

Education of TURKEY Sept. 1988-May 1988

Graduate Fellowship, West Chester University Jan, 1988-May 1988

APPOINTMENTS

ACADEMIC

Assistant Professor, (non-tenure tract)

Temple University Biology Department Apr. 2002- Jun 2005

Assistant Professor, (non-tenure tract)

Temple University School of Medicine Jun 2005- Nov 2010

Assistant Professor, (tenure tract)

Temple University School of Medicine Nov 2010-Present

OTHER OPPOINTMENTS

Co-op student

Dr. Christopher Jones’s laboratory GalaxoSmithKline Pharmaceuticals Jun-1987-May 1988

King of Prussia, PA USA

Research Specialist II

Dr. James Garbern’s laboratory University of Pennsylvania

Philadelphia, PA USA Jun 1988-May 1993

PROFESSIONAL ACTIVITIES

EDUCATIONAL (TEACHING)

Lecturer, Neurobiology of Disease (NSI 2222),

Lectured on Tay-Sachs disease and Phenolketoneuria

Temple University, Psychology Department Feb, 16 &18, 2010

2010-Present Lecturer, Neuroprotection and Loss (8702)

Lectured on Posttranslational modifications.

Temple University School of Medicine Apr, 15 & 20, 2010

2009-Present Lectures, Molecular Neuro-oncology (8701)

Lectured on Viral oncology

Temple University School of Medicine Oct. 30, 2010

Nov. 2, 6 &10, 2010

Lecturer, Advanced Topics in Molecular Biology,

Temple University Biology Department 2001-2002

Lecturer, Virology

Temple University Biology Department 2002-2004

POST-DOCTORAL FELLOWS AND OTHER SCIENTIST SUPERVISED

Asif Chowdhury, Wright State University, Dayton, OH, USA 2009- 2009

Beata Sadowska, Visiting Fellow, University of Lodz, Poland 2000- 2001

GRADUATE STUDENTS SUPERVISED

1. Ilker Sariyer, (was graduate student at

19 Mayis University, Samsun, TURKEY) 2003-2007

2. Ilhan Akan, (was graduate student at

Akdeniz University, Antalya, TURKEY) 2004-2006

3. Renato Biffi, (was graduate student at

University of Milan, Institute of Virology, Milan, ITALY) 2002-2003

4. Elisa Borghi, (was graduate student at

Laboratory of Biology, Don C. Gnocchi Foundation, Milan, ITALY) 2002-2002

UNDERGRADUTE STUDENTS SUPERVISED

(They were either Independent Study (IS) or Summer Students (SS) in my lab.

1. Sarah Mun, Biology, (IS), Department, Temple University 2011-present

2. Pyounghwa Park (IS), Biology Department, Temple University 2010-present

3. Thomas Minford (IS),, Chemistry Department, Temple University 2011-2011

4. Phong Le (IS), Biology Department, Temple University 2010-2010

5. Victor Benvenuto (IS), Biology Department, Temple University 2009-2010

6. Sehal Patel (IS), Biology Department, Temple University 2009-2010

7. Cathy Lam (IS), Chemistry Department, Temple University 2009-2010

8. Anam Butt (IS), Biology Department, Temple University 2008-2009

9. Polina Pomerants (IS), Biology Department, Temple University 2008-2009

10. Hassan Kumas (IS), Biology Department, Temple University 2008-2009

11. Firaz Ido (IS), Biology Department, Temple University 2008-2008

12. Jacqueline Tung (IS), Biology Department, Temple University 2007-2008

13. Ornela Dervishaj (IS), Biology Department, Temple University 2006-2007

14. Erkanda Plaku (IS), Biology Department, Temple University 2006-2007

15. Ferhan Tuncer, (SS) Rowan University, NJ 2006-Summer

16. Natasha Fonseka, Biology Department, Temple University 2006-Summer

17. Priti Patnayaruni, (SS) Biology Department, Temple University 2006-Summer

18. Victoria Palermo (IS), Biology Department, Temple University 2004-2006

19. Erin Davis, (SS) Biology Department, Temple University 2005-Summer

20. Adebukola Adetoro (IS), Biology Department, Temple University 2005-Spring

21. Shqiponja Dervishaj (IS), Biology Department, Temple University 2004-Spring

22. Michel Tramontana (IS), Biology Department, Temple University 2004-Fall

23. Stephanie Woolridge (IS), Biology Department, Temple University 2002-2004

24. Joanne Kim (IS) Biology Department, Temple University 2002-2003

25. Jean Kim (IS), Biology Department, Temple University 2001-2002

26. Robert Barrucco (IS), Biology Department, Temple University. 2000-2001

MEMBERSHIP ON PH.D. THESIS COMMITTEES


Neuroscience Department

Ilker Sariyer (Ph.D student) 2009-2011


Neuroscience Department

Evan Notch (MD/Ph.D. Student) 2010-2011

GRANT SUPPORT

Active Support

NIH-RO1 NS043108-06A1

Agnoprotein in JC virus virion biogenesis and replication

Principle Investigator

Total direct costs per year: $250,000

Funding period: 08/01/08- 07/31/13

NIH-RO1 AI077460

Cytokine regulation of JC virus latency and reactivation

Co-principle Investigator


Funding period: 02/01/08- 01/31/13

Previous support:

NIH RO1 NS43108

Role of Agnoprotein in JC virus life cycle

Principal investigator


Funding period: 04/01/02-03/31/08

PROFESSIONAL PUBLICATIONS

Journal of Virology, reviewed papers for this journal 1999-Present

Virology, reviewed papers for this journal 1999-Present

Journal of Neurovirology, reviewed papers for this journal 2001-Present

Plos Pathology, reviewed papers for this journal 2011-Present

NATIONAL/INTERNATIONAL CONFERENCES/MEETINGS

The 2nd

International Conference on Viral Oncology, Philadelphia, PA

Co-Chairing session 6: Virus-Host factors in Transformation. Sept. 2008

PRESENTATIONS

International Conference and exhibition on Virology.Title of the presentation: Human polyomvirus JC

small regulatory agnoprotein forms highly stable homodimers and oligomers: Implications for their role

in agnoprotein function. Baltimore, MD, USA, Sept. 5, 2011

The 19th

Annual Meeting of the “Gesellschaft fur Virologie” (GfV, Society for Virology, Leipzig,

Germany:Title of the presentation: Molecular events associated with JC virus induced CNS disease.

March 20, 2009

Microbiology and Immunology Research Seminar Series, Drexel University School of Medicine,

Philadelphia, PA, USA. Dec. 10, 2008

The 3nd

International Conference on the Polyomaviruses and Human Diseases, Providence, Rhode

Island, USA. Sept. 13, 2005

The 2nd

International Conference on the Polyomaviruses and Human Diseases, Sappora Convention

Center, Sappora, Japan. June 12, 2004.

Neuroimmunology Seminar Series, Department of Neurology, Johns Hopkins University School of

Medicine, Maryland, MD, USA. March 4, 2004,

Department of Biology Seminar Series, Temple University, Philadelphia, PA, USA. Feb. 16, 2004

5th

International Symposium of Neurovirology, HIV Molecular and Clinical Neuroscience Workshop,

Baltimore, MD, USA. Sept. 4, 2003

Center for Neurovirology and Cancer Biology Seminar Series, Department of Biology, Temple

University, Philadelphia PA USA. Nov 14, 2001

SERVICE

EXTERNAL ADVISORY COMMITTEES/

REVIEW GROUPS

Scientific Reviewer, Department of Veteran affairs, (VHA CO INDA Review) Dec 9, 2005

Scientific Reviewer, National Institute of Dental and Craniofacial Research,

Special Emphasis Panel (RFA DE 04-002) (NIDCR), Feb 16-17, 2005


Special Emphasis Panel (RFA DE 04-002) (NIDCR), Nov. 21-22, 2003


Special Emphasis Panel (RFA DE 03-002) (NIDCR), July 22, 2002

PROFESSIONAL ORGANIZATIONS

New York Academy of Sciences, member 1998-1990

American Society for Microbiology, member 1998-present

International Society of Neurovirology, member 1999-present

PUBLICATIONS

PEER-REVIEWED ARTICULES

1. Saribas,S., Arachea, B.T., White, M.K., Viola, R.E., Safak, M. (2011) Human polyomavirus JC

small regulatory agnoprotein forms highly stable dimers and oligomers: Implications for their roles

in agnoprotein function. Virology (in press)

2. Sariyer, I.K., Saribas, A.S., White, M.K., Safak, M. (2011). Infection by agnoprotein-negative

mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in

DNA content.

Virol J. 8:255.

3. Wollebo, H.S., Del Valle, L., Safak, M., Khalili, K., White, M.K. (2011). Role for tumor necrosis

factor-alpha in JC virus reactivation and progressive multifocal leukoencephalopathy. J

Neuroimmunol. 233:46-53.

4. JC virus-induced CNS disease, Progressive Multifocal Leukoencephalopathy (2010). Saribas AS,

Ozdemir A., Lam, C. and Safak, M. (Review).

Future Virol. 5: 313-323

5. Modulation of JC virus transcription by C/EBPbeta. (2009) Romagnoli L, Wollebo HS, Deshmane

SL, Mukerjee R, Del Valle L, Safak, M, Khalili K, White MK.

Virus Res. 146: 97-106.

6. Regulation of gene expression in primate polyomaviruses. (2009) White MK, Safak, M, Khalili K.

J Virol.83:10846-56.

http://www.ncbi.nlm.nih.gov/pubmed/21609431



http://www.ncbi.nlm.nih.gov/pubmed/19747512?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

http://www.ncbi.nlm.nih.gov/pubmed/19640999?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

7. Sariyer, I. K., Safak, M., Gordon, J. and Khalili, K (2009). Generation and characterization of JCV-

permissive hybrid cell lines.

Journal of Virological Methods 159: 122–126

8. Romagnoli, L., Sariyer I.K., Tung, J., Feliciano, M., Sawaya, B.E., Del Valle, L., Ferrante, P., Khalili,

K., Safak, M., White, M.K. 2008. Early growth response-1 protein is induced by JC virus infection

and binds and regulates the JC virus promoter.

Virology 375:331-41.

9. Sariyer, I. K., Khalili, K., and Safak, M. 2008. Dephosphorylation of JC virus agnoprotein by

protein phosphatase 2A: Inhibition by small t antigen.

Virology 375:464-79.

10. Stanisszewska, I., Sariyer, I. K., Lecht, S., Brown, C. M., Walsh, E. M., Tuszynski, G. P., Safak, M.

Lazarovici, P. and Marcinkiewicz, C. 2008. The integrin a9b1 is a receptor for nerve growth factor

and other neutrophins.

J Cell Sci. 121:504-13.

11. Khalili, K., Sariyer, I.K., Safak, M. 2008. Small tumor antigen of polyomaviruses: role in viral life

cycle and cell transformation.

J Cell Physiol. 215(2):309-19. Review.

12. Claudio P. P., Cui. I., Ghafouri, M., Mariano, C., White, M. K., Safak, M., Sheffield, J. B.,

Giordano, A., Khalili, K., Amini, S., Sawaya, B. E. 2006. Cdk9 phosphorylates p53 on serine 392

independently of CK II.

J. Cell Physiol. 208:602-612

13. Sariyer, I.K., Akan, I., Palermo, V., Gordon, G., Khalili, K., and Safak, M. 2006. Phophorylation

mutants of JC virus agnoprotein are unable to sustain the viral infection cycle.

J. Virol 80: 3893-3903

14. Akan, I., Sariyer, I.K., Biffi, R., Palermo, V., Woolridge, S., White, M.K., Amini, S., Khalili, K., and

Safak, M. 2006. Human polyomavirus JCV late leader peptide region contains important regulatory

elements.

Virology 349:66-78

15. Khalili, K., White. M. K., Sawa, H., Nagashima, K., and Safak, M. 2005. The agnoprotein of

polyomaviruses: A multifunctional auxiliary protein.

J. Cell. Physiol. 204: 1-7. Review.

16. Sariyer, I. K., Akan, I., Valle, L.D., Khalili, K., and Safak, M. (2004). Tumor induction by simian

and human polyomaviruses.

Cancer Therapy 2:85-98. Review.

17. Khalili, K., L. Del Valle, Y. G. Wang, N. Darbinian, A. Lassak, M. Safak, and K. Reiss. 2003. T-

antigen of human polyomavirus JC cooperates with IGF-IR signaling system in cerebellar tumors of

the childhood-medullablastomas.

Anticancer Res. 23:2035-41.

18. Abraham, S., B. E. Sawaya, M. Safak, O. Batuman, K. Khalili, and S. Amini. 2003. Regulation of

MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells.

Virology 309:196-202.

19. Safak, M., and K. Khalili. 2003. An overview: Human polyomavirus JC virus and its associated

disorders.

J. Neurovirol. Suppl. 1:3-9.

20. Kim, J., S. Woolridge, R. Biffi, E. Borghi, A. Lassak, P. Ferrante, S. Amini, K. Khalili and M.

Safak. 2003. The members of AP-1 family, c-Jun/c-Fos, functionally interact with JC virus early

regulatory protein large T antigen.

J. Virol. 77:5241-52

21. Sadowska, B., R. Barrucco, K. Khalili, and M. Safak. 2003. Regulation of human polyomavirus JC

virus gene transcription by AP-1 in glial cells.

J. Virol. 77:665-72

22. Darbinyan, A., N. Darbinian, M. Safak, S. Radhakrishnan, A. Giordano, and K. Khalili. 2002.

Evidence for dysregulation of cell cycle by human polyomavirus JCV, late auxiliary protein.

Oncogene 21:5574-81

23. Safak, M., B. Sadowska, R. Barrucco, and K. Khalili. 2002. Functional interaction between cellular

Y-box binding protein, YB-1 and JC virus late Agnoprotein .

J. Virol. 76:3828-3838.

24. Ansari, S. A, M. Safak, L. Del Valle, S. Enam, S. Amini, and K. Khalili. 2001. Cell cycle

regulation of NF-B binding activity in cells from human glioblastomas.

Exp. Cell Res. 265:221-33. (First two authors are equally contributed to this work).

25. Safak, M., and K. Khalili. 2001. Physical and functional interactions between viral and cellular

proteins modulate JCV gene transcription.

J. Neurovirol. 7:288-92.

26. Safak, M., R. Barrucco, R. Darbinyan, y. Okada, K. Nagashima, and K. Khalili. 2001. Interaction of

JC virus Agno protein with T antigen modulates transcription and replication of viral genome in glial

cells.

J. Virol. 75:1476-1486.

27. Safak, M., G. Gallia and K. Khalili. (1999). Functional and physical interaction between Y-box

binding protein and human polyomavirus JC virus large T-antigen.

J. Virol. 73:10146-10157.

28. Ansari, S., M. Safak, G. Gallia and K. Khalili. 1999. Interaction of YB-1 with human

immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity.

J. Gen. Virol. 80:229-236.

29. Safak, M., G. Gallia and K. Khalili. 1999. A 23-bp sequence element from human polyomavirus, JC

virus, is responsive to NF-B subunits.

Virology 262:178-189.

30. Safak, M., G. Gallia and K. Khalili. 1999. Reciprocal interaction between two cellular proteins,

Pur and YB-1 modulates transcriptional activity of JCVCy in glial cells.

Mol. Cell. Biol. 19:2712-2723.

31. Safak, M. 1999. A 23 base pair sequence element and its role in JC virus gene transcription.

Ph. D. Thesis, Thomas Jefferson University, Philadelphia PA.

32. Gallia, G., M. Safak, and K. Khalili. 1998. Interaction of single-stranded DNA binding protein,

Pur, with human polyomavirus JC virus early protein T-antigen.

J. Biol. Chem. 273:32662-32669.

33. Raj, G V., M. Safak, G. H. McDonald, and K. Khalili. 1996. Transcriptional regulation of human

polyomavirus, JC: Evidence for a functional interaction between RelA (p65) and the Y-box binding

protein YB-1.

J. Virol. 70: 5944-53.

35. Mayreddy, R P., M. Safak, M. Razmara, P. Zoltick, K. Khalili. 1996. Transcription of the JC virus

archetype late promoter: Importance of the kappa B and the 23-base-pair motifs in late promoter

activity in glial cells.

J. Virol. 70: 2387-93.

35. Safak, M. 1992. The role of macrophages in herpes simplex virus type-2 infections in mice in vivo

and in vitro.

Master Thesis, West Chester University, West Chester, PA.

BOOK CHAPTERS

1. Khalili K, Safak, M, Del Valle L, White MK. JC virus molecular biology and the human

demyelinating disease, progressive multifocal leukoencephalopathy. Chapter 10 in “Neurotropic

virus infections”. C. Shoshkes Reiss (Ed.). Cambridge University Press, Cambridge, UK. pp 190-

211. 2008.

2. Safak, M. and Khalili, K. Polyomaviruses and Papillomaviruses. In: Encyclopedia of Microbiology,

Third edition (Moselio Schaechter, ed.), Elsevier Ltd, Oxford, UK, in press. 2008.

3. Safak, M. and Khalili, K. Polyomaviruses (Polyomaviridae): JC and BK viruses. In:

Encyclopedia of Virology, 3rd edition (B. Mahy and M. van Regenmortel, eds), Elsevier, Ltd,

Oxford, UK, in press. 2008.

4. Otte, J., Safak, M., and Khalili, K. Polyomaviruses Topley and Wilson’s Microbiology and

Microbial Infections. Viology volume, (book chapter) 10th

edition. Edited by B. W. J. Mahy and V.

ter Meulen. 2005.

5. Safak, M., Major, E., and Khalili, K. Human polyomavirus, JCV and progressive multifocal

leukoencephalopathy (book chapter). Neurology of AIDS. Edited by H. Gendalman. Second edition,

pp 461-474. 2004

ABSTRACTS

1. JC virus (JCV) Agnoprotein Binds to the Viral Transcripts: Implications for Its Role in Transport of

the Viral Transcripts From Nucleus to Cytoplasm. Sami Saribas, Buenafe T. Arachea, Ilker K

Sariyer, Buenafe T. Arachea†, Ronald E. Viola and Mahmut Safak. Presented Poster. 6th

Brain

Research Meeting, Washington DC, VA USA, Nov, 10-11, 2011.

2. JC virus agnoprotein forms highly stable homodimer/oligomer complexes and enhances large T

antigen binding to the origin of the viral DNA replication. Sami Saribas, Martyn K White and

Mahmut Safak. 2nd

ASM-conference on manipulation of nuclear processes by DNA viruses. Oct. 23-

26, 2011, Santa Fe, New Mexico. USA.

3. Human Polyomvirus JC Small Regulatory Agnoprotein Forms Highly stable homodimers and

oligomers: Implications for their role in agnoprotein function. Sami Saribas, Buenafe T. Arachea,

Ronald E. Viola and Mahmut Safak. International Conference and exhibition on Virology. Presented

poster. Baltimore, MD, USA, Sept. 5, 2011

4. Involvement of JC Virus Large T Antigen in Virion Assembly by Coupling of Viral DNA

Replication to Encapsidation Process. A. Sami Saribas, Ahmet Ozdemir and Mahmut Safak.

Presented poster 10th

International Symposium on Neurovirology, Milan, Italy

5. JCV and SV40 Virions are Efficiently Released in the Absence of Agnoprotein but They are

Deficient in Viral DNA Content: Implications for Involvement of Agnoprotein in Viral DNA

Replication and Virion Biogenesis. Ilker K. Sariyer, A. Sami Saribas, Ahmet Ozdemir and Mahmut

Safak. 10th

International Symposium on Neurovirology, Milan, Italy

6. JCV Agnoprotein Stimulates Large T Antigen Binding to Origin of DNA Replication and Phe35

Plays a Critical Role in this Process. Sami Saribas, Ahmet Ozdemir and Mahmut Safak. 10th

International Symposium on Neurovirology, Milan, Italy.

7. Role for Tumor Necrosis Factor-alpha in JC virus Reactivation and Progressive Multifocal

Leukoencephalopahy.Hassen S Wollebo, Mahmut Safak, Kamel Khalili and Martyn White. 10th

International Symposium on Neurovirology, Milan, Italy.

8. Role of JC virus Late Regulatory Agnoprotein in Virion Biogenesis. Ahmed Ozdemir, Ilker Kudret

Sariyer, Asif Chowdhury, Kamel Khalili and Mahmut Safak. Presented poster. 9th

International

Symposium on Neurovirology, Miami, USA. 2009

9. JC Virus Small Tumor Antigen Promotes Cell Cycle Progression and Induces Phosphorylation of

Akt and Gsk3-. Ilker K. Sariyer, Ahmet Ozdemir, Asif Chowdhury, Kamel Khalili and Mahmut

Safak. Presented poster. 9th

International Symposium on Neurovirology, Miami, USA. 2009

10. Generation and characterization of JCV-permissive cell lines produced between glioblastoma and

primary human fetal astrocytes. Ilker K Sariyer, Mahmut Safak, Jennifer Gordon, and Kamel Khalili.

Presented poster. 9th


11. C/EBP-beta regulates the JCV early and late promoters. Hassen S Wollebo, Luca Romagnoli, Satish

L Deshmane, Ruam Murkerjee, Luis Del Valle, Mahmut Safak, Kamel Khalili and Martyn K White.



12. The early growth response-1 protein is induced by JCV infection and binds and regulates the JCV

promoter. Martyn K White, Luca Romagnoli, Ilker K Sariyer, Mariha Feciciano, Basel E Sawaya,

Mahmut Safak, Luis Del Valle, Pasquale Ferrante, and Kamel Khalili. Published not presented. 8th

International Symposium on Neurovirology, San Diago, USA. 2008

13. Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: Inhibition by small t antigen.

Ilker Sariyer, Kamel Khalili and Mahmut Safak. Published not presented. 8th

International

Symposium on Neurovirology, San Diago, USA. 2008

14. JC virus small t antigen targets the host translation system. Ilker Sariyer, Kamel Khalili and Mahmut

Safak. Published not presented. 8th

International Symposium on Neurovirology, San Diago, USA.

2008

15. JC virus small t antigen targets CDC37, a molecular cheparone, involved in G1/S phase

transition. Ilker Kudret Sariyer, Kamel Khalili and Mahmut Safak. Presented poster. The 4th

International Conference on Polyomaviruses and Human Diseases, Barcelona, Spain. 2007

16. Rictor/mTOR complex is activated in JC virus small t antigen expressing cells. Ilker K. Sariyer,

Victoria Palermo, Renato Biffi, Stephany Woolridge, Kamel Khalili, and Mahmut Safak. Presented

poster. The 7th

International Symposium on Neurovirology, Philadelphia, PA. 2006

17. Human polyomavirus, JC virus (JCV), late regulatory agnoprotein is targeted by a serine/threonine

phosphatase, PP2A. Ilker K Sariyer, Victoria Palermo, Kamel Khalili and Mahmut Safak. Presented

poster. The 7th


18. Identification of JCV promoter GRS-binding protein as Egr-1. Luca Romagnoli, Mariha Feliciano,

Bassel E Sawaya, Mahmut Safak, Pasquale Ferrante, Kamel Khalili, and Martyn K White. Presented

poster. The 7th


19. Cdk9 phosphorylates p53 on Ser392 independently of CKII.

Pier Paolo Claudio, Jianqi Cui, Muhammad Ghafouri, Chiara Mariano, Martyn K White, Mahmut

Safak, Joel B Sheffield, Antonio Giordano, Kamel Khalili, Shohreh Amini and Bassel Sawaya.

The 7th


20. The late leader peptide region of JC virus contains critical regulatory elements. Ilhan Akan, Ilker

Kudret Sariyer, Victoria Palermo, Stefanie Woolridge, Kamel Khalili and Mahmut Safak. Presented

poster.

The 3nd

International Conference on the Polyomaviruses and Human Diseases, Providence, Rhode

Island, USA. 2005

21. Phosphorylation mutants of JC virus agnoprotein are unable to sustain viral replication cycle. Ilker

Kudret Sariyer, Ilhan Akan, Victoria Palermo, Stefanie Woolridge, Shohreh Amini, Kamel Khalili

and Mahmut Safak. Presented poster. The 3nd

International Conference on the Polyomaviruses and

Human Diseases, Providence, Rhode Island, USA. 2005

22. JC Virus replication is attenuated in the absence of the C-terminal unique region of Small t antigen.

Renato Biffi, Ilker Kudret Sariyer, Ilhan Akan, Victoria Palermo, Stefanie Woolridge, Kamel Khalili

and Mahmut Safak. Presented poster. The 3nd

International Conference on the Polyomaviruses and

Human Diseases, Providence, Rhode Island, USA. 2005

23. Agnoprotein and Its Coding Sequences Play Important Roles in JC Virus Regulation. Renato Biffi,

Ilker Kudret Sariyer, Sujatha Radhakrishnan, Ilhan Akan, Stefanie Woolridge, Jennifer Gordon,

Shohreh Amini, Kamel Khalili and Mahmut Safak. Presented poster. The 2nd

International

Conference on the Polyomaviruses and Human Diseases, Sappora Convention Center, Sappora,

Japan. 2005

24. Human polyomavirus, JC virus, small tumor antigen promotes cell cycle progression. Renato Biffi,

Ilker Kudret Sariyer, Ilhan Akan, Stefanie Woolridge, Pasquale Ferrante, Kamel Khalili and Mahmut

Safak. Presented poster. The 2nd

International Conference on the Polyomaviruses and Human

Diseases, Sappora Convention Center, Sappora, Japan. 2004

25. JC Virus small tumor antigen promotes cell cycle progression. Renato Biffi, Stefanie Woolridge,

Ilker Sariyer, Joanne Kim, Kamel Khalili and Mahmut Safak. Presented poster. The Miami Nature

Biotechnology Winter Symposia, Miami, USA. 2004

26. The human polyomavirus, JC virus, small tumor antigen accelerates cell cycle progression. Renato

Biffi, Stefanie Woolridge, Joanne Kim, Darryl L’Heureux, Kamel Khalili, and Mahmut Safak.


International Symposium of Neurovirology, Baltimore, MD, USA. 2003

27. Agnoprotein plays an important role in human polyomavirus, JC virus, gene transcription and

replication in glial cells. Sujatha Radhakrishnan, Renato Biffi, Stefanie Woolridge, Joanne Kim,

Jennife Gordon, Kamel Khalili, and Mahmut Safak. Presented poster. 5th

International Symposium

of Neurovirology, Baltimore, MD, USA. 2003

28. Functional interaction between cellular Y-box binding protein, YB-1 and JC virus late Agnoprotein.

Beata Sadowska, Robert Barucco, Kamel Khalili and Mahmut Safak. Presented poster. 4th

International Symposium on Neurovirology, Dusseldorf, Germany. 2002

29. AP-1 family of transcription factors, c-Jun and c-Fos, regulate transcription from JC virus promoters

in glial cells. Beata Sadowska, Robert Barucco, Kamel Khalili and Mahmut Safak. Presented poster.

4th

International Symposium on Neurovirology, Dusseldorf, Germany. 2002

30. Physical and functional interaction between JC virus late auxiliary protein Agno and early viral

protein large T-antigen. Mahmut Safak , Robert Barrucco, Armine Darbinyan, and Kamel Khalili.

Presented poster. Third international symposium on Neurovirology, San Francisco, CA. 2000

31. Association of Agno-protein with HIV-Tat. Armine Darbinyan, Nune Darbinyan, Mahmut Safak,

Jennifer Gordon, and Kamel Khalili. Presented poster. Third international symposium on

Neurovirology, San Francisco, CA. 2000

32. Regulation of JCV archetype promoter function: Evidence that a 23-bp sequence restricts the

transcription of JCV archetype late promoter activity. Mahmut Safak and Kamel Khalili. Presented

poster. First International symposium on Neurovirology, Philadelphia, PA USA. 1997

curriculum vitae - temple universitycurriculum vitae _____ page 1 mahmut safak, ph.d. business...

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