curriculum vitae- samuel achilefu,...
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Curriculum Vitae- SAMUEL ACHILEFU, PhD
Date: October 1, 2013
Citizenship: U.S.A.
Address: Washington University School of Medicine, Mallinckrodt Institute of Radiology Department of Radiology,
4525 Scott Avenue, St. Louis, MO 63110 Phone: 314-362-8599 (Office) 314-995-8540 (Home) E-mail: [email protected]
Present Position: Professor of Radiology
Professor of Biochemistry and Molecular Biophysics Professor of Biomedical Engineering
Director, Optical Radiology Laboratory Director, Washington University Molecular Imaging Center
Leader, Oncologic Imaging Program of the Siteman Cancer Center Washington University School of Medicine, St. Louis, Missouri, USA
Education
Graduate:
1991 PhD (Molecular/Materials Chemistry), University of Nancy, France
Postgraduate:
1991-1993 Postdoctoral Training (Oxygen transport systems and Hematology), Oxford University, Oxford, England
Academic Positions/Employment:
2009-present Professor of Biomedical Engineering, Washington University, St. Louis, MO
2008-present Professor of Biochemistry and Molecular Biophysics, Washington University School of Medicine (WUSM), St. Louis, MO
2006-present Professor of Radiology, WUSM, St. Louis, MO
2006-present Visiting Professor, China Pharmaceutical University, Nanjing, China
2005-2006 Associate Professor of Radiology, WUSM, St. Louis, MO
2001-2004 Assistant Professor of Radiology, WUSM, St. Louis, MO
2002-present Chief, Optical Radiology Laboratory, WUSM, St. Louis, MO
2001 (Feb) Visiting Professor, Urology Department, Virginia Commonwealth University, Richmond, VA
2000 Visiting Research Associate Professor, University of Missouri, St. Louis, MO
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1999-2000 Principal Scientist, Discovery Research, Mallinckrodt, Inc., St. Louis, MO
1997-1998 Senior Research Chemist, Mallinckrodt Inc., St. Louis, MO
1997-1999 Visiting Scholar, University of Missouri, St. Louis, MO
1993-1996 Research Chemist, Discovery Research, Mallinckrodt, Inc., St. Louis, MO
1991-1993 Research Assistant, Oxford University, Oxford, UK
1989-1991 Teaching Assistant, University of Nancy, Nancy, France
Honors and Awards
2012 Trustee, Loma Linda University, CA
2011 SPIE Fellow, International Society for Optics and Photonics
2010-2015 Overseas Distinguished Expert Award, China Pharmaceutical University, Nanjing
2008 Achiever Award, St. Louis Science Center, MO
1998 Extraordinary Performance Award, Mallinckrodt, Inc., St. Louis, MO
1995 Technical Innovation Award, Mallinckrodt Medical, Inc., St. Louis, MO
1994-2000 Featured as “St. Louis Scientist” at the St. Louis Science Center, MO
1991 Distinguished PhD thesis, University of Nancy, France
1987-1991 French Government Scholarship for academic merit
University Appointments and Committees
2013-present Leader, Oncologic Imaging Program of the Siteman Cancer Center
2013 Director, Washington University Molecular Imaging Center
2011-present Member, Admissions Committee, Medical Scientist Training Program
2011-present Member, Oncologic Imaging Leadership Committee of the Siteman Cancer Center
2010-present Member, Radiological Sciences Executive Committee, MIR
2010-present: Founding Sponsor and Faculty Advisor, Washington University in St. Louis Student Chapter of the Optical Society of America
2010-present: Founding Sponsor and Faculty Advisor, Washington University in St. Louis Student Chapter of the SPIE - Biomedical Optics Society
2007-2010 Member, Promotion Committee, Department of Radiology, Washington University School of Medicine, St. Louis, MO
2007-2010 Member, Faculty Diversity Committee, Washington University School of Medicine, St. Louis, MO
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Editorial Responsibilities
Editorial Board
2004-present Member, Editorial Board, Current Analytical Chemistry
2001-present Member, Editorial Board, Journal of Biomedical Optics
Guest Editor
2013 Guest Editor, Special Section on Fluorescence Molecular Imaging Honoring Prof. Roger Tsien, Journal of Biomedical Optics
2010 Guest Editor, Special Section on Concepts and Strategies for Molecular Imaging, May 2010 Chemical Reviews (Impact Factor >40 in 2011)
2005 Guest Editor, Special Section on Chemical and Genetic Sensors in Biomedical Research, 2005 Journal of Biomedical Optics
Editor
2013 S. Achilefu, R. Raghavachari, [Editors]: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications BO209. Proceedings of SPIE, 8596 (SPIE, Bellingham, WA 2013)
2012 S. Achilefu, R. Raghavachari, [Editors]: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications BO209. Proceedings of SPIE, 8233 (SPIE, Bellingham, WA 2012)
2011 S. Achilefu, R. Raghavachari, [Editors]: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications BO209. Proceedings of SPIE, 7910 (SPIE, Bellingham, WA 2011)
2010 S. Achilefu, R. Raghavachari, [Editors]: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications BO209. Proceedings of SPIE, 7576 (SPIE, Bellingham, WA 2010)
2009 S. Achilefu, R. Raghavachari, [Editors]: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications BO209. Proceedings of SPIE, 7190 (SPIE, Bellingham, WA 2009)
2008 S. Achilefu, D. J. Bornhop, R. Raghavachari, [Editors]: Molecular Probes for Biomedical Applications II. Proceedings of SPIE, Vol 6867 (SPIE, Bellingham, WA, 2008)
2007 S. Achilefu, D. J. Bornhop, R. Raghavachari, [Editors]: Genetically Engineered and Optical Probes for Biomedical Applications IV. Proceedings of SPIE, Vol 6449 (SPIE, Bellingham, WA, 2007)
2006 S. Achilefu, D. J. Bornhop, R. Raghavachari, [Editors]: Optical Molecular Probes for Biomedical Applications. Proceedings of SPIE, Vol 6097 (SPIE, Bellingham, WA, 2006)
2005 D. J. Bornhop, S. I. Achilefu, R. Raghavachari, A. P. Savitsky [Editors]: Genetically Engineered and Optical Probes for Biomedical Applications II. Proceedings of SPIE, Vol 5704 (SPIE, Bellingham, WA, 2005)
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2004 A. P. Savitsky, D. J. Bornhop, R. Raghavachari, S. I. Achilefu, [Editors]: Genetically Engineered and Optical Probes for Biomedical Applications II. Proceedings of SPIE, Vol 5329 (SPIE, Bellingham, WA, 2004)
2003 A. P. Savitsky, D. J. Bornhop, R. Raghavachari, S. I. Achilefu, [Editors]: Genetically Engineered and Optical Probes for Biomedical Applications. Proceedings of SPIE, Vol 4967 (SPIE, Bellingham, WA, 2003)
2002 S. Achilefu, R. B. Dorshow: Dynamic and continuous monitoring of renal and hepatic functions with exogenous markers. Chapter 2, Topics in Current Chem. Vol 222, 31-72 (2002)
Reviewer - Scientific Journal Manuscripts
1. ACS Nano
2. Angewandte Chimie, International
3. Biochemistry
4. Biochemistry Journal
5. Bioconjugate Chemistry
6. Bioorganic & Medicinal Chemistry Letters
7. Bioorganic & Medicinal Chemistry
8. Cancer Investigation
9. Cancer Research
10. Chemical Communication
11. Chemical Reviews
12. Chemistry- A European Journal
13. Chemistry – An Asian Journal
14. Clinical Cancer Research
15. Current Analytical Chemistry
16. Inorganic Chemistry
17. Journal of the American Chemical Society
18. Journal of Biomedical Optics
19. Journal of Inorganic Biochemistry
20. Journal of Inorganic Chemistry
21. Journal of Medicinal Chemistry
22. Journal of Organic Chemistry
23. Journal of Porphyrins and Phthalocyanines
24. Molecular Imaging
25. Nature
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26. Nature Chemical Biology
27. Nature Medicine
28. Nature Methods
29. Nature Nanotechnology
30. Nature Photonics
31. Organic Letters
32. Photochemistry & Photobiolology
33. Proceedings of the National Academy of Sciences
34. Tetrahedron Letters
Professional Societies and Organizations
Professional Membership
2009-present Biophysical Society
2005-present Society for Molecular Imaging (Councilor, 2006-2008)
2004-present The Science Council, UK (Chartered Scientist)
2003-present American Society for Photobiology
2003-present American Peptide Society
2001-present Siteman Cancer Center, Washington University in St. Louis, MO
2001-present Optical Society of America
1999-present Society of Nuclear Medicine
1999-present International Society for Optical Engineering (SPIE)
1999-present Biomedical Optical Society (BiOS)
1993-present Royal Society of Chemistry, UK (Chartered Chemist)
1989-present American Chemical Society
Board and committee Membership 2012-2017 Member, Board of Trustees, Loma Linda University, Loma Linda, CA
2011-2015 Member, Babcock University Governing Council, Illishan-Remo, Nigeria
2009-2013 Member, Steering Committee, National Cancer Institute Network for Translational Research
2008-present Member, Scientific Advisory Board, National Center of X-ray Tomography, Lawrence Berkeley National Laboratory
2004-present Member, Scientific Advisory Board, National Cancer Institute Intramural Molecular Imaging Center
2009-2012 Member, Board of Directors, Society of Nuclear Medicine’s Center for Molecular
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Imaging Innovation and Translation (CMIIT)
2009-2012 Member, Task Force on Membership and Optical imaging issue, Society of Nuclear Medicine’s CMIIT
2009-2010 Leader, Molecular Probes and Guided Therapy Core, National Cancer Institute Network for Translational Research
2003-2010 Member, Scientific Advisory Board, ART Inc, Canada
2006-2008 Member, Governing Council Member, Society for Molecular Imaging
2005-2009 US Coordinator, Department of State International Scientists Cooperation and Anti-Weapons Proliferation Program
Professional Activities –Proposal Reviews
2009-present Regular Member, NIH Medical Imaging Study Section
2002-present Scientific Reviewer, NIH Special Emphasis/P50 Panels, and ad hoc member, Study Sections
2004-present Reviewer, US Army Breast Cancer Research Program
2010-2011 Chair, NIH Cell Biology & Molecular Imaging Study Section (SBIR)
2010 Chair, Department of Defense CDMRP Review Panel on Lung Cancer Research Program Collaborative Translational Research Award
2010 Co-Chair, SBIR Special Emphasis Panel
2004-2008 Regular Member, NIH Microscopic Imaging Study Section
2007 Chair, NIBIB Special Emphasis Panel (ZEB1 OSR-D (M2)
2007 Chair, Study Section on “Detection, Diagnosis, and Prognosis” of the Susan Komen Breast Cancer Foundation
2007 Member, Programmatic Review Panel of the Susan Komen Breast Cancer Foundation
2007 Member, Peer and Programmatic Review Procedures Committee of the Susan Komen Breast Cancer Foundation
2006-2008 Member, National Cancer Institute Advisory Review panel, Network for Translational Research: Optical Imaging (NTROI)
2006 Member, Bioengineering Fellowships Review Panels (2/16/2006 and 7/31/2006)
2005 Reviewer, Department of Defense Era of Hope Scholars Award
2005 Reviewer, Department of State International Scientists Cooperation and Anti-Weapons Proliferation Program
Professional Activities –Conference and Meeting Leadership
2012 Session Chair, Biomedical Optics (BIOMED) of the OSA Advancing the Science and Technology of Light. April 28-May 2, 2012 (Miami, FL)
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2009-present Conference Chair and Session Chair, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications, Photonics West, held 3rd week of January yearly (San Jose, CA)
2003-present Executive Committee Member, Photonics West - Annual meeting of the International Society of Optical Engineers-SPIE (San Jose, CA)
2010 Discussion leader, GRC on Lasers in Medicine & Biology, July 25-30, 2010 (Plymouth, NH)
2010 Session Chair, AACR Annual Meeting 2010 Methods Workshop entitled:
“Imaging Methods for Preclinical Models of Cancer”, April 17-18, 2010
(Washington DC)
2010 Program Chair, Photonic nanotechnology and probes, Optical Society of America Optics & Photonics Congress, April 11-14, 2010 (Miami, Fl)
2009 Session Chair, Nanobiophotonics and Molecular Probes at Engineering Conferences International-Advance in Optics for Biotechnology, Medicine and Surgery XI-Clinical Challenges and Research, June 28- July 2, 2009 (Burlington, VT)
2008 Session Chair, Optical Molecular Imaging, 2008 Annual Meeting of the Biomedical Engineering Society (St. Louis, MO)
2008 Session Chair, Biophotonics IV: Novel Approaches in Nano-Biophotonics, 21st Annual Meeting of the IEEE Lasers & Electro-optics Society (Newport Beach, CA)
2003-2008 Conference Chair and Session Chair, Genetically Engineered and Optical Probes for Biomedical Applications, Photonics West, held 3rd week of January yearly (San Jose, CA)
7/10-14/2007 Co-Conference Chair, Engineering Foundation Conference - Advances in Optics for Biotechnology, Medicine, and Surgery (Naples, Fl)
10/11-14/2006 Session Chair, Biomedical Engineering Society Annual Meeting - Advances in Tissue, Cellular, and Molecular Probes (Chicago, IL)
7/2-7/2006 Session Chair, The new era of molecular photomedicine, Gordon Conference on Lasers in Medicine and Biology (Holderness, NH)
6/13-16/2005 Organizing Committee Member, European Conference on Biomedical Optics (Munich, Germany)
9/9-12/2004 Session Chair, Society for Molecular Imaging 3rd Annual Meeting (St. Louis, MO)
3/28-4/1/2004 Chair, American Chemical Society Symposium on Chemistry and Biologic Properties of Molecular Beacons and Imaging Agents (Anaheim, CA)
4/14-17/2004 Organizing Committee Member, Biomedical Topical Meetings, Optical Society of America (Miami, FL)
7/5-9/2003 Session Chair, 31st Annual Meeting of the American Society for Photobiology (Baltimore, MD)
2000-2002 Session Chair, Molecular Probes and Dyes, Photonics West (San Jose, CA)
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9/26/2002 Panelist, NIH Workshop on Optical Imaging, Bethesda, MD
Consulting Relationships
2011 Consultant Vice Chancellor for Research Affairs, Loma Linda University, CA
2002-2007 Tyco Healthcare Mallinckrodt, Inc., St. Louis, MO
2001-2006 Biosynthema, Inc., St. Louis, MO
2004-2005 GE Healthcare, Waukesha, WI
2004 Amersham Biosciences K.K, Tokyo, Japan
2003 ART, Inc., Montreal, Canada
2003 Optosonics, Inc., Indianapolis, IN
Scientific Presentations and Lectures
Invited Presentations and Lectures
1. S. Achilefu: Translating molecular imaging - Optical. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Vancouver, Canada (June 9, 2013); sponsored by
the Center for Molecular Imaging Innovation and Translation.
2. S. Achilefu: Fluorescent and Nuclear Imaging Agents. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Vancouver, Canada (June 9, 2013); co-sponsored
by the Optical Society of America
3. S. Achilefu: The search for universal optical molecular imaging probes for tumors. Optics in Life Sciences Congress, Kona HI (April 17, 2013)
4. S. Achilefu: Image-guided tumor resection using complementary goggle device and molecular probe. Medical Biophysics Seminar, University of Toronto/Princess Margaret Hospital, Toronto, Canada (January 21, 2013)
5. S. Achilefu: Optical Methods for Molecular Optical Imaging of Tumors. 4th Shanghai International Forum of Regional and Targeting Therapies for Cancer. Shanghai, China (November 10 - 12, 2012)
6. S. Achilefu: Tackling the challenges of translating optical molecular probes from bench to bedside. World Molecular Imaging Congress. Dublin, Ireland (September 5-8, 2012)
7. S. Achilefu: Spotlight Session: SNM - Approaching the Challenges of Translating Molecular Imaging Agents into the Clinic. World Molecular Imaging Congress 2012. Dublin, Ireland (September 5-8, 2012)
8. S. Achilefu: The role of serendipity in molecular imaging. Gordon Research Conference. Lasers in Medicine & Biology. Plymouth, NH (July, 24, 2012)
9. S. Achilefu: Application of Goggle System for NIR Fluorescence Image-Guided Surgery. SNM 2012 Annual Meeting. Miami Beach, FL (June 9, 2012)
10. S. Achilefu: Serendipity in Molecular Optical Imaging. 2012 Imaging at Illinois: The Next
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Generation. University of Illinois at Urbana-Champaign. (June 1, 2012) Keynote Speaker
11. S. Achilefu: Optical activatable fluorescent probes. 3rd Multimodal Cardiovascular Molecular Imaging Symposium. NIH Bethesda, MD (April 19, 2012)
12. S. Achilefu: Tumor Imaging with NIR Molecular Probes. PIITCON Conference & Expo 2012. Orlando, FL (March 11, 2012)
13. S. Achilefu: Spying on cancer with nifty molecular fluorescent agents and devices: from cells to humans. The Rockefeller University, New York, NY (January 12, 2012)
14. S. Achilefu: Central role of chemists in unraveling the molecular basis of diseases with invisible light. Plenary Lecturer at 34th CSN Annual International Conference (KWARA) Nigeria (September 20, 2011)
15. S. Achilefu: Dual spect radioisotopes for imaging molecular processes. Department of Defense Breast Cancer Research Program Era of Hope Conference. Orlando, FL (August 4, 2011)
16. S. Achilefu: New optical contrast mechanisms and methods for molecular imaging of tumors. 7th International Conference on Biological Physics (ICBP2011) La Jolla, CA (June 24, 2011)
17. S. Achilefu: Imaging methods and novel molecular probes for preclinical studies. Fitzpatrick Institute for photonics Seminar Series, Duke University, NC (May 16, 2011)
18. S. Achilefu: Optical contrast mechanisms and methods for molecular imaging of tumors. University of Central Florida (April 25, 2011)
19. S. Achilefu: Spying on cancer with nifty molecular fluorescent agents and devices: from cells to humans. Siteman Cancer Center Oncologic Imaging Seminar Series, Washington University School of Medicine (April 22, 2011)
20. S. Achilefu: Basic concepts and applications of image-guided optical imaging in tumor resection. Fudan University, Shanghai, China (February 22, 2011)
21. S. Achilefu: Multifunctional nanoparticles for optical imaging of tumors. AACR Special Conference on Nano in Cancer: Linking Chemistry, Biology, and Clinical Applications In Vivo. Miami, FL (January 13, 2011)
22. S. Achilefu: Optical contrast mechanisms and methods for molecular imaging of tumors.
University of Louisville, James Graham Brown Cancer Center (December 9, 2010)
23. S. Achilefu: Optical molecular imaging of diseases. China Pharmaceutical University, China (October 21-27, 2010)
24. S. Achilefu: Inflammatory breast cancer. Wayne State University, Detroit, MI (September 22, 2010)
25. S. Achilefu: Molecular and functional imaging of tumors using optical and multimodal platforms. International Symposium on Primo-Vascular System. (September 17-18, 2010)
26. S. Achilefu: The pursuit of excellence. Keynote address, 2010 graduation, Biomedical Research Apprenticeship Program/Cellular and Developmental Biology Apprenticeship Program, Washington University School of Medicine, St. Louis, MO (August 6, 2010)
27. S. Achilefu: Nanoparticles for imaging cancer. 2010 Nano-Biophotonics Summer School,
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University of Illinois, Urbana-Champaign, IL (June 1, 2010)
28. S. Achilefu: Seize the challenge. Commencement Speaker, School of Science and Technology, Loma Linda University, Loma Linda, CA (May 13, 2010)
29. S. Achilefu: Fluorescence lifetime imaging of tumors. 101st American Association for Cancer Research, Washington DC (April 17-21, 2010)
30. S. Achilefu: The era of nanomedicine: Perspectives and potential applications in breast and prostate cancer. 1st National Conference on Cancer Control, Kuwait (November 9-10, 2009)
31. S. Achilefu: Potential Roles of Optical Molecular Imaging & Guided Therapies in Prostate Cancer Metastases. 1st National Conference on Cancer Control, Kuwait (November 9-10, 2009)
32. S. Achilefu: Optical Imaging for Breast Cancer. 1st National Conference on Cancer Control, Kuwait (November 9-10, 2009)
33. S. Achilefu: Localization and characterization of tumors by optical molecular imaging. Fudan University Liver Cancer Center Seminar, Shanghai, China (October 21, 2009)
34. S. Achilefu: Preclinical optical molecular imaging of cancer with tumor-selective molecular probes. Yangtze River 2009 International Conference on Medical Imaging Physics & the 5th National Annual Meeting of Medical Imaging Physics, Nanjing, China (October 23-25, 2009)
35. S. Achilefu: Bispecific gold nanoparticles for near infrared fluorescence imaging of caspase-3 activation. 1st Symposium on Nanotechnology for Public Health, Environment, and Energy, St. Louis, MO (September 24-25, 2009)
36. S. Achilefu: Nanoparticles and nanomolecules in tumor imaging. Engineering Conferences International-Advance in Optics for Biotechnology, Medicine and Surgery XI-Clinical Challenges and Research Solutions., Burlington, VT (June 28- July 2, 2009)
37. S. Achilefu: Applications of optical imaging. NCI Imaging Camp, St. Louis, MO (June 21-26, 2009)
38. S. Achilefu: Flip-flopping contrast mechanisms in optical molecular imaging. 2009 Nano-Biophotonics Summer School, University of Illinois, Urbana-Champaign, IL (June 9, 2009)
39. S. Achilefu: Functional and molecular optical imaging of tumors. AUR 57th Annual Meeting, Arlington, VA (May 11-12, 2009)
40. S. Achilefu: Lighting up tumors with optical molecular probes. Plenary speaker, Japanese Society of Molecular Imaging Meeting, Tokyo, Japan (May 14-15, 2009)
41. S. Achilefu: Flip-flopping contrast mechanisms in optical imaging. The Lester Wolfe Workshop, Harvard-MIT Division of Health Sciences and Technology, Boston, MA (November 25, 2008)
42. S. Achilefu: 21st Annual Meeting of The IEEE Lasers & Electro-Optics Society, Newport Beach, CA (November 9-13, 2008)
43. S. Achilefu: Nanomolecules and Nanoparticles in Optical Tumor Imaging and Drug Discovery. World Molecular Imaging Conference, Nice, France (September 10-13, 2008)
44. S. Achilefu: Tailored molecular probes for optical imaging of molecular processes. World
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Molecular Imaging Conference, Nice, France (September 10-13, 2008)
45. S. Achilefu: Challenges of translating optical molecular probes from bench to bedside. High Level Seminar on Molecular Imaging, CEA-LETI, Grenoble, France (September 7-9, 2008)
46. S. Achilefu: Fluorescence lifetime imaging of tumors using near-infrared fluorescent molecular probes. 236th National Meeting of the America Chemical Society, Philadelphia, PA (August 17-21, 2008)
47. S. Achilefu: Chemical and biochemical contrast strategies for optical imaging of molecular processes in vivo. 236th National Meeting of the America Chemical Society, Philadelphia, PA (August 17-21, 2008)
48. S. Achilefu: Fluorescence lifetime imaging in vivo. Gordon Research Conference on Lasers in Medicine & Biology, Holderness, NH (July 20-25, 2008)
49. S. Achilefu: Hidden treasures of invisible light - harnessing the power of light for imaging and treating diseases. Biomed RAP Lecture, Washington University School of Medicine, St. Louis, MO (July 15th, 2008)
50. S. Achilefu: Molecular Optical Imaging. Lecture series for the National Cancer Institute Imaging Camp. Duke University Durham, NC (June 15-20, 2008)
51. S. Achilefu: Nanomolecules and nanoparticles in optical imaging of tumors.
Nanotechnology Seminar Series, Center for Nanotechnology, University of Washington,
Seattle, WA (May 5-7, 2008)
52. S. Achilefu, W. Akers, M. Berezin, A. Almutairi, J. Frechet: Imaging molecular processes by
optical methods. 34th Annual Meeting and Exposition of the Controlled Release Society,
Long `Beach, CA (July 9, 2007)
53. S. Achilefu: Basic principles and practice of molecular optical imaging of tumors using
contrast agents. Lecture Series, Radiology Department, University of Louisville School of
Medicine, Louisville, KY (March 26, 2007)
54. S. Achilefu: Optical imaging of tumors in mice using colorful molecules. NSF/IGERT
Seminar Series, University of Texas at Austin, TX (March 2, 2007)
55. S. Achilefu: Optical molecular imaging of malignant tumors. LI-COR Seminar Series,
Lincoln, NE (February 16, 2007)
56. S. Achilefu: Identifying molecular targets: lessons from PET for optics Workshop on
“Prospects of Molecular Imaging from Bench to Bedside”, BiOS 2007, San Jose, CA (January
21, 2007)
57. S. Achilefu: Spying cancers with colorful molecules. Molecular Optics and Spectroscopy
Seminar Series, MIT, Boston MA (December 12, 2006)
58. S. Achilefu: Discovery and Development of Diagnostic and therapeutic Drugs for Medical
Intervention. Department of Chemistry Seminar Series, Georgia State University, Atlanta,
GA (November 2, 2006)
59. S. Achilefu: From in vitro to in vivo imaging of tumor molecular targets by optical methods.
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Walther Cancer Research Center Seminar Series, University of Notre Dame, Notre Dame,
IN (October 9, 2006)
60. S. Achilefu: Spying cancers with colorful molecules. Academy of Science –St. Louis
Scientific Frontiers Seminar Series, St. Louis, MO (October 6, 2006)
61. S. Achilefu: Nanomolecules and nanomaterials in optical imaging of tumors. Fifth Inter-
Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside at the NIH,
Bethesda, MD (September 25-27, 2006)
62. S. Achilefu: Functional imaging technologies – optical tracers and applications. Advances
in Therapeutic Discovery and Drug Development Seminar Series sponsored Academy of
Molecular Imaging and MPI Research, Augusta, MI (September 20-22, 2006)
63. S. Achilefu: Spying tumors with optical molecular probes. Engineering School lecture
Series, Ecole Polytechnique de Montreal, Montreal, Canada (June 15, 2006)
64. S. Achilefu: The role of optical molecular probes in drug discovery and cancer imaging. US
FDA Seminar Series, Washington DC (June 13, 2006)
65. S. Achilefu: Synthesis and evaluation of contrast agents for imaging cancer by optical
methods. Chemistry Colloquium, Department of Biomedical Engineering, Florida
International University, Miami, FL (June 5, 2006)
66. S. Achilefu: Molecular probe-assisted optical imaging of diseases. Invited Lectures, China
Pharmaceutical University and Nanjing University of Aeronautics and Astronautics,
Nanjing, China (February 20-24, 2006)
67. S. Achilefu: Synthesis and evaluation of contrast agents for imaging cancer by optical
methods. Chemistry Colloquium, Department of Chemistry, Boston University, Boston, MA
(December 12, 2005)
68. S. Achilefu: Spying tumors with optical molecular probes.. 5th Annual University of Texas
Southwestern In Vivo Cancer Cellular and Molecular Imaging Program Symposium, Dallas
TX (December 8, 2005)
69. S. Achilefu: Near infrared imaging of prostate cancer using molecular probes. Image-
Guided, Minimally Invasive Diagnosis & Treatment of Prostrate Cancer Care Conference,
Washington DC (October 27-29, 2005)
70. S. Achilefu: Molecular probe-assisted optical imaging of diseases. Visiting Speaker
Seminars, Department of Biomedical Engineering, Boston University, Boston, MA (October
20, 2005)
71. S. Achilefu: Rational design, synthesis, and biodistribution of disease-specific molecular
probes. 4th Annual Meeting of the Society for Molecular Imaging, Cologne, Germany
(September 7-10, 2005)
72. S. Achilefu: Molecular imaging 101 - Optical imaging primer. 52nd Annual Meeting of the
Society for Nuclear Medicine, Toronto, Canada (June 20, 2005)
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73. S. Achilefu: Harnessing the power of light to non-invasively image and localize diseases in
small animals. GE Asia-Pacific World Lecture Series – S. Korea: Busan; China: Shanghai and
Beijing; New Zealand: Auckland; Australia: Sidney and Melbourne; and Thailand: Bangkok;
(May 9-20, 2005)
74. S. Achilefu: Highly specific optical molecular probes for imaging tumors. Health Science
and Engineering Seminar Series, University of Michigan, Ann Arbor, MI (March 15, 2005)
75. S. Achilefu: Applications of optical molecular imaging in biology and medicine. Molecular
Imaging Workshop, San Jose, CA (January 23, 2005)
76. S. Achilefu: Molecular imaging. Guest Speaker (Hot Topics) at the Biomedical Optics
Society Symposium, SPIE Photonics West, San Jose, CA (January 22, 2005)
77. S. Achilefu: Highly specific optical molecular probes for imaging tumors and monitoring
tumor therapy. Frontiers in Optics 2004, Optical Society of America, Rochester, NY
(October 10-14, 2004)
78. S. Achilefu: Molecular designs for targeting and imaging human diseases in small animal
models by optical. University of Wisconsin Biomedical Engineering Seminar Series,
Madison, WI (October 4, 2004)
79. S. Achilefu: Recent advances in optical molecular probes. Optical Imaging Workshop 2004:
Fourth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside at
the NIH, Bethesda, MD (September 20-22, 2004)
80. S. Achilefu, Y. Ye, S. Bloch, Z. Zhang, M. Berezin, K. Liang. Development of Contrast Effectors
for Optical and Multimodal Imaging of Tumors. 228th American Chemical Society National
Meeting, Philadelphia, PA (August 22-26, 2004)
81. S. Achilefu, Y. Ye, S. Bloch, Z. Zhang, R. Dorshow, K. Liang, Molecular Optical Probes for
Imaging Tumors. IEEE/LEOS Summer Topical Meeting, San Diego, CA (June 28-30, 2004)
82. S. Achilefu: The role of optical molecular probes in tumor imaging and organ function
monitoring. Seminar Series, Intramural Research, National Institute of Child Health &
Human Development, NIH, Bethesda, MD (December 8, 2003)
83. S. Achilefu: Lighting up tumors by optical methods. Roswell Cancer Institute Seminar,
Buffalo, NY (December 1, 2003)
84. S. Achilefu: Contrast Agent-Mediated Optical Imaging of Tumors. Fall Meeting, American
Association of Physicists in Medicine, Missouri River Valley Chapter, St. Louis, MO
(November 8, 2003)
85. S. Achilefu: Receptor-specific near infrared molecular probes for imaging aberrant protein
expression in vivo. MGH Wellman Laboratories of Photomedicine Lecture Series, Boston,
MA (September 30, 2003)
86. S. Achilefu: Near infrared molecular probes for imaging protein expression. Imaging in
2020, Jackson Hole, WY (September 7-11, 2003)
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87. S. Achilefu: Contrast agent-mediated organ function monitoring and tumor imaging by
optical methods. Advances in Optics for Biotechnology, Medicine and Surgery, Banff,
Alberta, Canada (August 3-7, 2003)
88. S. Achilefu, Y. Ye, S. Bloch: Diagnosis and treatment of tumors by optical methods. The 31st
Annual Meeting of the American Society for Photobiology, Baltimore, MD (July 5-9, 2003)
89. S. Achilefu: Design of optical imaging agents. NIH Workshop on Imaging the Pancreatic
Beta Cells, Bethesda, MD (April 21-22, 2003)
90. S. Achilefu: Imaging and monitoring therapeutic response of tumors by optical methods.
Washington University Small Animal Imaging Symposium, St. Louis, MO (April 14, 2003)
91. S. Achilefu: Optical imaging – instrumentation and methods. Siteman Cancer Center
Oncologic Seminar Series, Washington University Medical School, St. Louis, MO (December
9, 2002)
92. S. Achilefu: Optical contrast agent-mediated imaging of tumors. Advanced Research
Technologies Seminar Series, Montreal, Canada (October 16, 2002)
93. S. Achilefu: Optical contrast agents for tumor imaging. Optical Imaging Workshop 2002:
Third Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside at
the NIH, Bethesda, MD (September 26-27, 2002)
94. S. Achilefu: Somatostatin beacon: a reliable model for targeted delivery. The Society for
Molecular Imaging Annual Meeting, Boston, MA (August 26-27, 2002).
95. S. Achilefu: The role of exogenous contrast agents in optical imaging of tumors and organ
function monitoring. The Speed School of Engineering Seminar Series, University of
Louisville, Louisville, KY (April 12, 2002)
96. B. Chance, Y. Chen, J. Glickson, D. Blessington, L. Zhao, G. Zheng, P. Lu, S. Achilefu, C. Tung:
Breast cancer detection by phased array localization of fluorescent molecular beacons.
International School for Young Scientists and Students on Optics, Laser Physics and
Biophysics, Saratov Fall Biomedical Optics Meeting, Saratov, Russia, (October 1-4, 2002)
97. S. Achilefu: Molecular beacons in optical imaging. Plenary Speaker (Hot Topics) at the
Biomedical Optics Society Symposium, San Jose, CA (January 20, 2001)
98. R. B. Dorshow, R. Rajagopalan, J. E. Bugaj, and S. Achilefu: Targeting exogenous optical
agents for tumor diagnosis and therapy. Optical Society of America Annual Meeting, Long
Beach, CA (October 15, 2001)
99. S. Achilefu: The few, the proud, the challenged. The Optical Imaging of Brain Function
Minority Summer Program Graduation, University of Pennsylvania, Philadelphia, PA
(August 17, 2001)
Other Scientific Presentations
1. Y. Liu, W. J. Akers, G. P. Sudlow, K. Liang, S. Achilefu: Image-guided liver surgeries using
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fluorescence goggle system. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
2. T. Charanya, G. P. Sudlow, K. Gullicksrud, K. Liang, N. Kotagiri, W. J. Akers, D. C. Rubin, S. Achilefu: Assessment of surgical margins in an orthotopic colorectal cancer model by optical imaging. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
3. Y. Pu, W. Wang, G. Tang, S. Achilefu, R. R. Alfano: Near infrared spectral polarized imaging using Cybesin - a smart receptor-targeted contrast agent of prostate cancer. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
4. M. Y. Berezin, K. Guo, S. Achilefu: Fluorescence lifetime for blood stain age dating. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
5. Y. Liu, W. J. Akers, A. Q. Bauer, G. P. Sudlow, K. Liang, J. P. Culver, S. Achilefu: Surgical oncology aided by fluorescence goggle system. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
6. J. Cao, S. Huang, Y. Chen, S. Li, S. Achilefu, Z. Qian, Y. Gu: Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
7. J. Zhao, S. Achilefu, Y. Gu: MUC1 aptamer based near infrared fluorescence probes for tumor diagnosis. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
8. Y. Pu, R. Tang, W. Wang, B. Xu, D. Shen, S. Bloch, M. Zhou, S. Achilefu, R. R. Alfano: Synthesis of dye-bioconjugates to visualize cancer cells using fluorescence microscopy. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
9. S. Li, J. Cao, S. Achilefu, Y. Gu: Docosahexaenoic acid conjugated near infrared fluorescence probe for in vivo early tumor diagnosis. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
10. S. H. Pahng, M. Zhou, S. Achilefu: Perfluorinated near-IR dye labeled fluorescent micelle for imaging of tumor hypoxia. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
11. L. A. Sordillo, G. Milione, P. P. Sordillo, B. Das, W. Wang, S. Achilefu, R. R. Alfano: Time-resolved fluorescence polarization for breast cancer detection in vitro using an octreotide-indocyanine green conjugate. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
12. M. Solomon, W. J. Akers, K. I. Shoghi, S. Achilefu, J. P. Culver: Dynamic fluorescence mediated tomography. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
13. Y. Pu, J. Xue, B. Xu, W. Wang, Y. Gu, R. Tang, S. Achilefu, R. R. Alfano: Investigation of native fluorescence spectral difference among prostate cancer cell lines with different risk levels. SPIE Photonics West, San Francisco, CA (February 2-7, 2013)
14. M. Solomon, W.J. Akers, K. I. Shoghi, S. Achilefu, J. P. Culver: Dynamic Fluorescence Mediated Tomography. World Molecular Imaging Conference 2012. Dublin, Ireland (September 5-8, 2012)
15. T.P. Gustafson, Y. Yan, P. Newton, D.A. Hunter, S. Achilefu, W.J. Akers, S.E. Mackinnon, P.J. Johnson, M.Y. Berezin: Identification and Classification of Peripheral Nerve Injuries with Optical Imaging in the Near-infrared. American Society for Peripheral Nerve 2012 Annual Meeting, Las Vegas, NV (January 14-15, 2012)
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16. G. Sudlow, K. Gullicksrud, L. Sudlow, W. Akers, S. Achilefu: Exploring the Novel Primo Vascular System. Mallinckrodt Institute of Radiology 2012 Poster Session, Washington University School of Medicine, St. Louis, MO (February 21, 2012)
17. R. Nothdurft, S. Bloch, J. P. Culver, S. Achilefu: Fluorescence Lifetime Imaging Microscopy Using Near-Infrared Contrast Agents. Mallinckrodt Institute of Radiology 2012 Poster Session, Washington University School of Medicine St. Louis, MO (Feb. 21, 2012)
18. T.P. Gustafson, Y. Yan, P. Newton, D.A. Hunter, S. Achilefu, W.J. Akers, S.E. Mackinnon, P.J. Johnson, M.Y. Berezin: Design NIR dyes for Optical Imaging of Peripheral Nerves. Mallinckrodt Institute of Radiology 2012 Research Poster Session, Washington University School of Medicine St. Louis, MO (February 21, 2012)
19. T.P. Gustafson, Y. Yan, P. Newton, D.A. Hunter, S. Achilefu, W.J. Akers, S.E. Mackinnon, P.J. Johnson, M.Y. Berezin: NIR Optical Imaging of Peripheral Nerves, 8th Annual Washington University Postdoc Symposium, Washington University School of Medicine St. Louis, MO (March 29, 2012)
20. M. Solomon , R. Nothdurft, W.J. Akers, W. B. Edwards, K Liang, B. Xu, G. Sudlow, H. Deghani, Y.C. Tai, S. Achilefu, J. P. Culver: Multimodal Fluorescence DOT-SPECT/CT for Sentinel Lymph Nodes Mapping. BIOMED OSA 2012, Miami, FL (April 28-May 2, 2012)
21. M. Solomon, R. Nothdurft, W.J. Akers, W.B. Edwards , K. Liang, B. Xu, A.T. Eggebrecht, H. Dehghani, Y.C. Tai , S. Achilefu, J.P. Culver: Multimodal video-rate fluorescence DOT and SPECT/CT for small animals. BIOMED OSA 2012, Miami, FL (April 28-May 2, 2012)
22. Y. Liu, A. Q. Bauer, W. Akers, G. Sudlow, K. Liang, T. Charanya, S. Mondal, J. P. Culver, S. Achilefu: Fluorescence Goggle for Intraoperative Breast Cancer Imaging. Photonics West San Francisco, CA (January 21-26, 2012)
23. Y. Liu, W. Akers, A. Q. Bauer, G. Sudlow, K. Liang, J. P. Culver, S. Achilefu: Fluorescence Goggle for Surgical Navigation. OSA Technical Digest, 2012, Miami, FL (April 28-May 2, 2012)
24. Y. Liu, A. Q. Bauer, W. Akers, G. Sudlow, K. Liang, D. Shen, M. Berezin, J. P. Culver, S. Achilefu: Compact Intraoperative Imaging Device for Sentinel Lymph Node Mapping. SPIE Photonics West: Optical Tomography and Spectroscopy of Tissue IX San Francisco, CA (January 22-27, 2011)
25. M. Solomon, B.R. White, R. Nothdurft, W.J. Akers, A. Eggebrecht, S. Achilefu, J.P. Culver: Handheld Video Rate Fluorescence Diffuse Optical Tomography for Mapping Sentinel Lymph Nodes. SPIE Photonics West: Optical Tomography and Spectroscopy of Tissue IX San Francisco, CA (January 22-27, 2011)
26. R. Nothdurft, M. Solomon, W.J. Akers, H. Lee, Y.C. Tai, S. Achilefu, J. P. Culver: Towards quantified functional imaging with combined fDOT & PET/SPECT imaging. SPIE Photonics West 2011, San Francisco, CA (January 22-27 2011)
27. Y. Liu, A. Bauer, W.J. Akers, G. Sudlow, K. Liang, D. Shen, M. Berezin, J. Culver, S. Achilefu: Compact intraoperative fluorescence imaging device for imaging tumor margins and mapping sentinel lymph nodes. SPIE Photonics West 2011, San Francisco, CA (January 22-27, 2011)
28. K. Guo, M.Y. Berezin, J. Zheng, W.J. Akers, F. Lin, S. Achilefu, B. Teng, H. Gandjbakhche, G. Griffiths: Novel design of multimodal NIR optical/MRI agents for in vivo imaging, SPIE
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Photonics West 2011 San Francisco, CA (January 22-27, 2011)
29. M. Solomon, B.R. White, R. Nothdurft, W.J. Akers, A.T. Eggebrecht, S. Achilefu, J.P. Culver: Handheld Video Rate Fluorescence Diffuse Optical Tomography. SPIE Photonics West: Optical Tomography and Spectroscopy of Tissue IX San Francisco, CA (January 22-27, 2011)
30. R. Tang, H. Lee and S. Achilefu: "pH sensitive quantum dot probes for fluorescence lifetime imaging.” 7th Annual Postdoc Scientific Symposium, Washington University in St. Louis, St. Louis, MO (March 29, 2011)
31. W. Akers, M. Y. Berezin, H. Lee, S. Achilefu: Fluorescence Lifetime in Optical Molecular Imaging, OSA Optics and Photonics Congress 2011, Monterey, CA (April 4-6, 2011)
32. M. Solomon, R. Nothdurft, W.J. Akers, B.W. Edwards, K. Liang,, B. Xu, S. Achilefu, J.P. Culver: Multimodal Fluorescence DOT-SPECT/CT for Sentinel Lymph Nodes Mapping. Engineering Conference International: Advances in Optics for Biotechnology, Medicine and Surgery XII., Naples, FL (June 5-8, 2011)
33. M. Shokeen, E. Pressly, Y Liu, S. Achilefu, L. Potter, C. Hawker, M.J. Welch, P.K. Woodard, C.J. Anderson: In Cellulo Evaluation of NPR-C targeted 64Cu-C-ANF-Peptide and 64Cu-C-ANF-comb Nanoparticles. 19th International Symposium on Radiopharmaceutical Sciences, Amsterdam, Netherlands (August 28 - September 2, 2011)
34. M. Solomon, R. Nothdurft, W.J. Akers, W. B. Edwards, K. Liang, B. Xu, S. Achilefu, J. P. Culver: Multimodal Fluorescence DOT-SPECT/CT for Sentinel Lymph Nodes Mapping. World Molecular Imaging 2011, San Diego, CA (September 7-10, 2011)
35. R. Tang, H. Lee, D. Shen, S. Achilefu: A new strategy to sense pH of biological systems with near-infrared Qdot-dye conjugates using fluorescence lifetime reporting mechanism. 2011 World Molecular Imaging Congress, San Diego, CA (September 7-10, 2011)
36. M. Xu, M. Rettig, G. Sudlow, B. Wang , W.J. Akers, D. Cao, D. Mutch, J. Dipersio, S. Achilefu: Preclinical Evaluation of Mab CC188 for Ovarian Cancer. 2011 Imaging World Molecular Imaging Congress, San Diego, CA (September 7-10, 2011)
37. C. Chen, J. Wu, A.T. Eggebrecht, B.R. White, B. Chen, S. Achilefu, J.P. Culver: Hybrid level-set segmentation of MRI on optical properties. Biomedical Optics, Optical Society of America. Miami, FL (April 29-May 2, 2010)
38. M. Solomon, B.R. White, R. Nothdurft, W.J. Akers, A.T. Eggebrecht, S. Achilefu, J.P. Culver: Handheld Video Rate Fluorescence Diffuse Optical Tomography. Lasers in Medicine and Biology Gordon Research Conference, Holderness, NH. 2010.
39. M. Solomon, B.R. White, R. Nothdurft, Walter. J. Akers, A. Eggebrecht, S. Achilefu, J.P. Culver: Handheld Video Rate Fluorescence Diffuse Optical Tomography, World Molecular Imaging 2010, Kyoto, Japan. (September 8-11, 2010)
40. Y. Ye, B. Xu, S. Bloch, S. Achilefu: Synthesis, metal coordination, and cellular internalization of a siderophore-bearing NIR fluorescent carbocyanine probe. International Symposium on Biomedical Optics, San Jose, CA (January 22-24, 2006)
41. W.B. Edwards, K. Liang, B. XU, C.J. Anderson, S. Achilefu: Synthesis and radiolabeling of a somatostatin analog for multimodal imaging. International Symposium on Biomedical Optics, San Jose, CA (January 22-24, 2006)
42. D. Shen, K. Liang, Y.Ye, E. Tetteh, S. Achilefu: Preliminary study on the inhibition of
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nuclear internalization of Tat peptides by conjugation with a receptor-specific peptide and fluorescent dyes. International Symposium on Biomedical Optics, San Jose, CA (January 22-24, 2006)
43. Y. Ye, S. Bloch, B. Xu, S. Achilefu: Synthesis and evaluation of two NIR fluorescent cyclic RGD penta-peptides for targeting integrins. International Symposium on Biomedical Optics, San Jose, CA (January 22-24, 2006)
44. Z. Zhang, D. Shen, K. Liang, S. Achilefu: Design, synthesis, and evaluation of near-infrared fluorescent pH indicators at physiological range. International Symposium on Biomedical Optics, San Jose, CA (January 22-24, 2006)
45. S. Bloch, B. Xu, Y. Ye, K. Liang, S. Achilefu: Internalization of RGD peptide conjugates of near-infrared fluorescent probes in different cell lines occurs via different integrin receptor subtypes. International Symposium on Biomedical Optics, San Jose, CA (January 22-24, 2006)
46. J.P. Culver, S.V. Patwardhan, S. R. Bloch, S. Achilefu: Fast scanning fluorescence optical tomography for small animal whole body biodistribution assays. Frontiers in Optics, 89th Optical Society of America Annual Meeting, Tucson, AZ (October 16-20, 2005)
47. T. Hirche, J. Aregbesola, S. Bahr, S. Achilefu, A. Belaaouaj. Increased susceptibility of mice deficient in neutrophil elastase to pseudomonas aeruginosa lung infection. 18th Annual North American Cystic Fibrosis Conference, St. Louis, MO (October 14-17, 2004)
48. Y. Ye, S. Achilefu. Novel fluorescent carbocyanine-based molecular beacons - synthesis and metal binding properties. 228th American Chemical Society National Meeting, Philadelphia, PA (August 22-26, 2004)
49. Y. Ye, S. Bloch, S. Achilefu. Polyvalent carbocyanine dyes – synthesis and applications. 227th American Chemical Society National Meeting, Anaheim, CA (March 28-29, 2004)
50. P. Li, J.E. Sprague, J. Rutlin, S. Achilefu, C.J. Anderson: Molecular imaging of matrix metalloproteinases expression in metastatic tumors using a radiolabeled inhibitor and microPET. Annual Conference, Academy of Molecular Imaging. Orlando, FL (March 27-31, 2004)
51. E. Sprague, X. Sun, C.-H. Chang, G. R. Weisman, E. H. Wong, L. Meyer, S. Achilefu, C. J. Anderson: In vivo behavior of copper-64 labeled Y3-octreotate using a cross-bridged cyclam ligand. 15th International Symposium on Radiopharmaceutical Chemistry, Sydney, Australia (August 10-14, 2003)
52. B. Chance, J. Glickson, G. Zheng, H Li, C. Tung, S. Achilefu: Molecular beacons as an enhancement of small subsurface breast cancer detection. Era of Hope DoD Breast Cancer Research Program Meeting, Orlando, FL (September 25-28, 2002)
53. S. Achilefu, J. E. Bugaj, R. B. Dorshow, H. N. Jimenez, R. Rajagopalan: New approaches to optical imaging of tumors. International Symposium on Biomedical Optics, San Jose, CA (January 20-26, 2001)
54. R. Rajagopalan, S. Achilefu, M. Schmidt, E. G. Webb, J. E. Bugaj. And R. B. Dorshow: Targeted Type 1 phototherapeutic agents using novel azido-peptide bioconjugates. International Symposium on Biomedical Optics, San Jose, CA (January 20-26, 2001)
55. S. Achilefu, J. E. Bugaj, R. B. Dorshow, H. N. Jimenez, R. Rajagopalan, R. R. Wilhelm, E. G. Webb, and J. L. Erion: Site-specific tumor targeted fluorescent contrast agents. European Biomedical
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Optics Week, Amsterdam, The Netherlands (July 4-8, 2000)
56. S. Achilefu, J. E. Bugaj, R. B. Dorshow, R and Rajagopalan: Bioactive peptide-fluorescent dye conjugates for in vivo tumor imaging. Biomedical Topical Meetings, Miami Beach, FL (April 2-5, 2000)
57. R. B. Dorshow, S. Achilefu, J. E. Bugaj, and R. Rajagopalan: In vivo optical imaging using tumor specific exogenous fluorescent contrast agents. American Physical Society Meeting, Minneapolis, MN (March 20-24, 2000)
58. S. Achilefu, R. B. Dorshow, J. E. Bugaj, and R. Rajagopalan: Tumor specific fluorescent contrast agents. International Symposium on Biomedical Optics, San Jose, CA (January 22-28, 2000)
59. R. Rajagopalan, J. E. Bugaj, R. B. Dorshow, C. J. Venkatramani, P. A. Uetrecht, and S. Achilefu: Polyanionic fluorescent bioconjugates as tracer agents for continuous monitoring of renal function. International Symposium on Biomedical Optics, San Jose, CA (January 22-28, 2000).
60. R. B. Dorshow, J. E. Bugaj, R. Rajagopalan, and S. Achilefu: In vivo tumor imaging for optical contrast agent development. Optical Society of America 1999 Annual Meeting,, Santa Clara, CA (September 26-30, 1999)
61. R. Rajagopalan, P. Uetrcht, J. Bugaj, S. Achilefu, and R. Dorshow: Stabilization of cyanine and squaraine dyes: influence of non-covalent interactions. Optical Society of America Annual Meeting, Baltimore, MD (October 3-7, 1998)
62. S. Achilefu, D. White, S. Matondo, W. Jones, R. Ashcroft, S. Maw, and S. Cooper: From pockets full of metal to empty pockets. 207th ACS National Meeting, San Diego, CA (March 13-17,1994)
63. S. Achilefu, S. Cooper: New auto-emulsifying fluorocarbon derivatives for blood substitutes. Fluorine in Medicine in the 21st Century, Manchester, UK (April 18-21, 1994)
64. S. Achilefu, P. Slade, M. Snodin, S. Cooper: Self-emulsifying tripodal surfactant for artificial blood: a convergent synthesis. 205th ACS National Meeting, Denver, CO (March 28-April 2, 1993)
Patents
Issued US Patents (excluding the corresponding World patents and 55 published US patent pending applications as of September 30, 2013)
1. S. Achilefu, H. Lee, J. C. Mason: Fluorescent polymethine cyanine dyes. US Patent 8,344,158 (Issued January 1, 2013)
2. S. Achilefu, Y. Yunpeng: Macrocyclic cyanine and Indocyanine bioconjugates provide improved biomedical applications. US Patent 8,318,133 (Issued November 27, 2012)
3. S. Achilefu: Compounds having RD targeting motifs. US Patent 8,053,415 (Issued November 8, 2011)
4. S. Achilefu, Y. Yunpeng: Macrocyclic cyanine and Indocyanine bioconjugates provide improved biomedical applications. US Patent 7,850,946 (Issued December 14, 2010)
5. S. Achilefu, R. Rajagopalan, R.B. Dorshow, J.E. Bugai, J. E. Periasamy, P. Muthunadar: Receptor-avid exogenous optical contrast therapeutic agents. US Patent 7,790,144 (Issued September 7, 2010)
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6. S. Achilefu, R. Rajagopalan, R.B. Dorshow, J.E. Bugaj, J. E. Periasamy: Optical diagnostic and therapeutic agents and compositions. US Patent 7,767,194 (Issued August 3, 2010)
7. R. Rajagopalan, S. Achilefu, J. E. Bugai, R. B. Dorshow: Dye-sulfenates for dual phototherapy. US Patent 7,758,861 (Issued July 20, 2010)
8. S. Achilefu, R. Rajagopalan, R.B. Dorshow, J.E. Bugaj, J. E. Periasamy: Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients. US Patent 7,608,244 (Issued October 27, 2009)
9. S. Achilefu, R. Rajagopalan, R.B. Dorshow, J.E. Bugaj: Versatile hydrophilic dyes. US Patent 7,566,444 (Issued July 28, 2009)
10. S. Achilefu, R. Rajagopalan, R.B. Dorshow, J.E. Bugaj, J.E. Periasamy, P. Muthunadar: Minimally invasive physiological function monitoring agents. US Patent 7,556,797 (Issued July 7, 2009)
11. S. Achilefu, R. Rajagopalan, R.B. Dorshow, J.E. Bugaj, J. E. Periasamy, P. Muthunadar: Tumor-targeted optical contrast agents. US Patent 7,514,069 (Issued April 7, 2009)
12. S. Achilefu, R.B.Dorshow, R. Rajagopalan, J.E. Bugai: Pathological tissue detection and treatment employing targeted benzoindole optical agents. US Patent 7,510,700 (Issued March 31, 2009)
13. S. Achilefu, R. Rajagopalan, R.B. Dorshow, J.E. Bugai, M.P. Periasamy: Receptor-avid exogenous optical contrast and therapeutic agents. US Patent 7,504,087 (Issued March 17, 2009)
14. S. Achilefu, R. Rajagopalan, R.B. Dorshow, J.E. Bugai, M.P. Periasamy: Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients. US Patent 7,468,177 (Issued December 23, 2008)
15. S. Achilefu, R. Rajagopalan, R. B. Dorshow, J. E. Bugai: Dyes for organ function monitoring. US Patent 7,438,894 (Issued October 21, 2008)
16. R. Rajagopalan, J. E. Bugai, S. Achilefu, R. B. Dorshow: Internal image antibodies for optical imaging and therapy. US Patent 7,431,925 (Issued October 7, 2008)
17. R. Rajagopalan, G.L. Cantrell, S. Achilefu, J. E. Bugai, R. B. Dorshow: Aromatic sulfenates for type 1 phototherapy. US Patent 7,427,657 (Issued September 23, 2008)
18. R. Rajagopalan, S. Achilefu, J. E. Bugai, R. B. Dorshow: Cyanine-sulfenates for dual phototherapy. US Patent 7,351,807 (Issued April 1, 2008)
19. R. Rajagopalan, S. Achilefu, J. E. Bugai, R. B. Dorshow: Methods and compositions for dual phototherapy. US Patent 7,303,926 (Issued December 4, 2007)
20. S. Achilefu, R. Rajagopalan, R. B. Dorshow, J. E. Bugai: Hydrophilic light absorbing compositions for determination of physiological function. US Patent 7,297,325 (Issued November 20, 2007)
21. S. Achilefu, R. B. Dorshow, R. Rajagopalan, J. E. Bugai: Pathological tissue detection and treatment employing targeted benzoindole optical agents. US Patent 7,252,815 (Issued August 7, 2007)
22. R. Rajagopalan, G. L. Cantrell, S. Achilefu, J. E. Bugai, R. B. Dorshow: Aromatic sulfenates
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for type I phototherapy. US Patent 7,235,685 (Issued June 26, 2007)
23. R. Rajagopalan, S. Achilefu, J. E. Bugai, R. B. Dorshow, M. P. Periasamy: Compounds for dual photodiagnosis and therapy. US Patent 7,230,088 (Issued June 12, 2007)
24. S. Achilefu, R. B. Dorshow, R. Rajagopalan, J. E. Bugai: Pathological tissue detection and treatment employing targeted optical agents. US Patent 7,201,892 (Issued April 10, 2007)
25. S. Achilefu, R. Rajagopalan, R. B. Dorshow, J. E. Bugai, M. P. Periasamy: Tumor-targeted optical contrast agents. US Patent 7,198,778 (Issued April, 3, 2007)
26. S. Achilefu, R. Rajagopalan, R. B. Dorshow, J. E. Bugai: Light sensitive compounds for instant determination of organ function. US Patent 7,175,831 (Issued February, 13, 2007)
27. S. Achilefu, R. B. Dorshow, R. Rajagopalan, J. E. Bugai: Pathological tissue detection and treatment employing targeted benzoindole optical agents. US Patent 7,128,896 (Issued October 31, 2006)
28. S. Achilefu, R. Rajagopalan, R. B. Dorshow, J. E. Bugai: Hydrophilic cyanine dyes. US Patent 7,011,817 B2 (Issued March 14, 2006)
29. S. Achilefu, R. Rajagopalan, R. B. Dorshow, J. E. Bugai: Versatile hydrophilic dyes. US Patent 6,939,532 B2 (Issued September 6, 2005)
30. S. Achilefu, H. N. Jimenez, R. Rajagopalan, R. B. Dorshow, J. E. Bugai: Compounds as dynamic organ function monitoring agents. US Patent 6,887,854 B2 (Issued May 3, 2005)
31. S. Achilefu, R. B. Dorshow, R. Rajagopalan, and J. E. Bugaj: Pathological tissue detection and treatment employing targeted benzoindole optical agents. US Patent 6,761,878 B2 (Issued July 13, 2004).
32. R. Rajagopalan, G. L. Cantrell, J. E. Bugaj, S. Achilefu, R. B. Dorshow: Azo compound for type I phototherapy. US Patent 6,747,151 B2 (Issued June 8, 2004).
33. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Indole compounds as minimally invasive physiological function monitoring agents. US Patent 6,733.744 B1 (Issued May 11, 2004).
34. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Indole compounds as tissue-specific exogenous optical agents. US Patent 6,716,413 B1 (Issued April 6, 2004).
35. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Receptor-avid exogenous optical contrast and therapeutic agents. US Patent 6,706,254 B2 (Issued March 16, 2004).
36. S. Achilefu, H. N. Jimenez, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Light sensitive compounds for instant determination of organ function. US Patent 6,673,334 B1 (Issued January 6, 2004).
37. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients. US Patent 6,669,926 B1 (Issued December 30, 2003).
38. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Dynamic organ function monitoring agents. US Patent 6,63,847 B1 (Issued December 16, 2003).
39. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Indole compounds as novel dyes for organ function monitoring. US Patent 6,656,451 B1 (Issued December 2, 2003).
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40. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Tumor-targeted optical contrast agents. US Patent 6,64,798 B2 (Issued November 4, 2003).
41. R. Rajagopalan, G. L. Cantrell, J. E. Bugaj, S. Achilefu, R. B. Dorshow: Azo compound for type I phototherapy. US Patent 6,485,704 B1 (Issued November 26, 2002).
42. R. Rajagopalan, J. E. Bugaj, R. B. Dorshow, and S. Achilefu: Non-covalent bioconjugates useful for diagnosis and therapy. US Patent 6,423,547 B1 (Issued July 23, 2002).
43. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Dendrimer precursor dyes for imaging. US Patent 6,395,257 B1 (Issued May 28, 2002).
44. A. H. Combs, R. D. Dorshow, J. E. Bugaj, R. Rajagopalan, and S. Achilefu: Simultaneous multimodal measurement of physiological function. US Patent 6,280,703 B1 (Issued August 28, 2001).
45. R. Rajagopalan, S. Achilefu, J. E. Bugaj, and R. B. Dorshow: Quinoline ligands and metal complexes for diagnosis and therapy. US Patent 6,277,841 B1 (Issued August 21, 2001).
46. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Tunable indocyanine dyes for biomedical applications. US Patent 6,264,920 B1 (Issued July 24, 2001).
47. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Indocyanine dyes. US Patent 6,264,919 B1 (Issued July 24, 2001).
48. R. B. Dorshow, S. Achilefu, R. Rajagopalan, and J. E. Bugaj: Method for measuring physiological function. US Patent 6,228,344 B1 (Issued May 8, 2001).
49. S. Achilefu, R. B. Dorshow, J. E. Bugaj, and R. Rajagopalan: Cyanine and indocyanine dye bioconjugates for biomedical applications. US Patent 6,217,848 B1 (Issued April 17, 2001).
50. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Indocyanine dyes. US Patent 6,190,641 B1 (Issued February 20, 2001).
51. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Versatile hydrophilic dyes. US Patent 6,183,726 B1 (Issued February 6, 2001).
52. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Tunable indocyanine dyes for biomedical applications. US Patent 6,180,087 B1 (Issued January 30, 2001).
53. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Hydrophilic cyanine dyes. US Patent 6,180,086 B1 (Issued January 30, 2001).
54. S. Achilefu, R. Rajagopalan, R. B. Dorshow, and J. E. Bugaj: Dyes. US Patent 6,180,085 B1 (Issued January 30, 2001).
55. S. Achilefu: Gaseous ultrasound contrast agents and methods therefor. US Patent 6,013,243 (Issued January 11, 2000).
Teaching and Mentoring Responsibilities Teaching
1. Optical Imaging (part of Imaging Science Pathway Course)
2. Optical nanoparticles in nanomedicine (part of Program of Excellence Program in
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Nanoparticles skills core)
3. Lecturer National Cancer Institute’s Cancer Imaging Camp at Washington University in St. Louis
4. Lecturer, Optical Imaging Primer, Society for Nuclear Medicine
5. Short course on Molecular Optical Imaging at the SPIE – Biomedical Optics Society
6. Guest lectures for High School Students, St. Louis Science Center
7. Chair at mock proposal reviews, DBBS
8. Guest speaker at DBBS summer program, BioMedRAP
Postdoctoral Fellows
1. Kvar Black, PhD, postdoctoral Research Associate, 2013 (Mentor)
2. Mingzhou Zhou, PhD, postdoctoral Research Associate, 2011 (Mentor)
3. Nalinikanth Kotagiri, postdoctoral Research Associate, 2011 (Mentor)
4. Pinaki Sarder, PhD, postdoctoral Research Associate, 2011 (Mentor)
5. Nibedita Sanyal, postdoctoral Research Associate, 2011 (Mentor)
6. Rui Tang, PhD, postdoctoral Research Associate, 2009-present (Mentor)
7. Xuan Zhang, PhD, postdoctoral Research Associate, 2010-present (Mentor)
8. Beret Oquare, PhD, postdoctoral Research Associate, 2009 (Mentor)
9. Mingfeng Bai, PhD, postdoctoral Research Associate, 2007-2010 (Mentor)
10. Jinda Fan, PhD, postdoctoral Research Associate, 2006-present (Mentor)
11. Duanwen Shen, PhD, postdoctoral Research Associate, 2004-2005 (Mentor)
12. Mikhail Berezin, PhD, postdoctoral Research Associate, 2003-2005 (Mentor)
13. Sharon Bloch, PhD, postdoctoral Research Associate, 2002-2005 (Mentor)
14. Zongren Zhang, PhD, postdoctoral Research Associate, 2002-2005 (Mentor)
15. Yunpeng Ye, PhD, postdoctoral Research Associate, 2001-2004 (Mentor)
16. Chinyere Azuogu, MD-III, Doris Duke Clinical Research Fellow, 2003-2004 (Mentor)
Graduate students, Washington University in St. Louis MO
1. Jessica Miller, MD/PhD Medical Scientist Training Program (MSTP), 2013-present (Advisor)
2. Rebecca Gilson, PhD Biomedical Engineering (BME) Student, 2012-present (Advisor)
3. Dolonchampa Maji, PhD Biomedical Engineering (BME) Student, 2012-present (Advisor)
4. Thomas Matthews, PhD BME research rotation student, 2012 (Advisor)
5. Tauseef Charanya, PhD BME Student, 2011-present (Advisor)
6. LeMoyne Habimana-Griffin, MD/PhD Medical Scientist Training Program (MSTP), 2011-
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present (Advisor)
7. Avik Som, MSTP Student, 2011-present (Advisor)
8. Suman Mondal, PhD BME Student, 2011-present (Advisor)
9. Shaw-Wei David Tsen, MSTP Student, 2011-present (Advisor)
10. Tenira Townsend, PhD Biochemistry Rotation Student (Advisor)
11. Yang Liu, PhD BME Student, 2009- 2013 (Advisor)
12. Metasebya Solomon, PhD BME Student, 2008- 2012 (Advisor)
13. Maria Trissal, MSTP Research Rotation Student, 2008 (Advisor)
14. Whitney Grither, MSTP Research Rotation Student, 2008, 2010 (Advisor)
15. Reece Goiffon, MSTP Research Rotation Student, 2008, 2008 (Advisor)
16. Joseph Livingston, MD Research Student, 2008 (Advisor)
17. Charles Odonkor, MS Developmental Biology Student, 2007- 2008 (Advisor)
18. Peter Slade, B.A. in Chemistry, Oxford University, Oxford, UK, July 1993 (Co-Advisor)
19. Michael Snodin, B.A. in Chemistry, Oxford University, Oxford, UK, July 1993 (Co-Advisor)
Other Graduate students (non- Washington University)
20. Kohtaro Ohara, MD Medical and Research Student, Saint Louis University 2011 (Advisor)
21. Joon Lee, MD Medical and Research Student, University of Illinois College of Medicine 2010 (Advisor)
Thesis Examination Committee
22. Yan Liu, Chemistry Department, Washington University, St. Louis, (WUSTL); 2013 PhD
23. Reece Goiffon, Radiology Department , (WUSTL); 2013 PhD
24. Yang Liu, Biomedical Engineering, Washington University, St. Louis (BME, WUSTL); 2013 PhD
25. Tracy Liu, University of Toronto, Canada; 2013 PhD
26. Metasebya Solomon, BME, WUSTL; 2012 PhD
27. Yu Wang, BME, WUSTL; 2012 PhD
28. Dandan Hu, Physics, WUSTL; 2012 PhD
29. Liang Song, BME-WUSTL; 2010 PhD
30. Jun Ma, Chemistry Department, WUSTL; 2010 PhD
31. Pinaki Sarder, Electrical Engineering, WUSTL; 2010 PhD
32. Ashley Fiamengo, Chemistry Department, WUSTL; 2009 PhD
33. Ximin Li, Chemistry Department, WUSTL; 2008 PhD,
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34. Bereket Oquare, Chemistry Department, WUSTL; 2007 PhD
35. Chulhong Kim, (BME-WUSTL) 2007-2009 PhD
36. Kristen Bullok, (BME-WUSTL) 2002-2005
37. Bing Ma, PhD thesis, State Univ. of New York, Buffalo, April, 2002 (External Thesis Examiner)
Undergraduate students
38. Samantha Renee Corber, National Nanotechnology Infrastructure Network, (NNIN) 2013(Advisor)
39. Seong Ho Pang, (HHMI SURF) 2012 (Advisor)
40. Kyle Gullicksrud, Undergraduate Student, Summer, 2011 (Mentor)
41. Kaleigh Margita, National Nanotechnology Infrastructure Network, (NNIN), 2012 (Advisor)
42. Audrey Dang, National Nanotechnology Infrastructure Network (NNIN), 2011 (Advisor)
43. Chantalle Le, National Nanotechnology Infrastructure Network (NNIN), 2010(Advisor)
44. Adithya Bhat, Howard Hughes Undergraduate Biology Fellow, 2007- 2009 (Mentor)
45. Louis Kang, MIR Summer Research Program, Undergraduate Student, Summer 2007 (Mentor)
46. Myers Dill, Biomedical Engineering Undergraduate Student, 2007-2008 (Mentor)
47. Franck Lin, Undergraduate Student, Summer 2009 (Mentor)
48. Tiffany Chen, Undergraduate Student, Summer 2008-2009 (Mentor)
49. Laura Bliss, undergraduate summer student intern 2005-2007 (Mentor)Elizabeth Tetteh, BiomedRAP undergraduate student, 2003 (Mentor)
50. Kirsten Block, Siteman Cancer Center-funded summer student, 2003 (Mentor)
51. Kristin Bullok, PhD thesis, DBBS, Washington University, St. Louis, 2002-2005 (PhD Thesis Committee)
High School students
52. Apurva Belsare, Students and Teachers as Research Scientist (STARS), 2013 (Advisor)
53. Neel Kothari, Students and Teachers as Research Scientist (STARS), 2011 (Advisor)
54. Richard Lu, Students and Teachers as Research Scientist (STARS), 2011 (Advisor)
55. Ashwath Sampath, Outstanding High School Student, summer 2010 (Mentor)
56. Kevin Guo, Outstanding High School Student, Summer 2006-2009 (Mentor)
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Bibliography 2013
1. N. Kotagiri, D.M. Niedzwiedzki, K. Ohara, S. Achilefu: Activatable probes based on distance-dependent luminescence associated with Cerenkov radiation. Angew Chem Int Ed Engl 52 7756-60 (2013)
2. D. Shen, M. Bai, R. Tang, B. Xu, X. Ju, R. G. Pestell, S. Achilefu: Dual fluorescent molecular substrates report selectively the activation, sustainability and reversibility of cellular PKB/Akt activity. Scientific Reports 3 1697 (2013)
3. Y. Liu, Y.M. Zhao, W. Akers, Z.Y. Tang, J. Fan, H.C. Sun, Q.H. Ye, L. Wang, S. Achilefu: First in-human intraoperative imaging of HCC using the fluorescence goggle system and transarterial delivery of near-infrared fluorescent imaging agent: a pilot study. Transl Res doi: 10.1016/j.trsl.2013.05.002 (2013)
4. Y. Liu, W. Akers, A. Q. Bauer, S. Mondal, K. Gullicksrud, G. Sudlow, J. P. Culver, S. Achilefu: Intraoperative detection of liver tumors aided by fluorescence goggle system and multimodal imaging. Analyst 8 2254-7 (2013)
5. D. Deng, L. Qu, S. Achilefu, Y. Gu: Broad spectrum photoluminescent quaternary quantum dots for cell and animal imaging. Chem Commun 49 9494-9496 (2013)
6. H. Chen, X. Zhang, S. Dai, Y. Ma, S. Cui, S. Achilefu, Y. Gu: Multifunctional gold nanostar conjugates for tumor imaging and combined phototheramal and chemo-therapy. Theranostics 3 633-649 (2013)
7. M. Zhou, X. Zhang, M. Bai, D. Shen, B. Xu, J. Kao, G. Xia, S. Achilefu: Click reaction-mediated functionalization of near-infrared pyrrolopyrrole cyanine dyes for biological imaging applications: RSC Adv 19 6756-6758 (2013)
8. Y. Liu, M. Solomon, S. Achilefu: Perspectives and potential applications of nanomedicine in breast and prostate cancer. Med Res Rev 33 3-32 (2013)
9. J. Wang, D. Wheeler, J.Z. Zhang, S. Achilefu, K.A. Kang: NIR fluorophore-hollow gold nanosphere complex for cancer enzyme-triggered detection and hyperthermia. Adv Exp Med Biol. 765 323-328 (2013)
10. C. Du, D. Deng, L. Shan, S. Wan, J. Cao, J. Tian, S. Achilefu, Y. Gu: A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug delivery. Biomaterials 34 3087-3097 (2013)
11. Y. Pu, J. Xue, W. Wang, B. Xu, Y. Gu, R. Tang, E. Ackerstaff, J.A. Koutcher, S. Achilefu, R.R. Alfano: Native fluorescence spectroscopy reveals spectral differences among prostate cancer cell lines with different risk levels. J. Biomed Opt 18 087002-5 (2013)
12. D. Deng, D. Zhang, Y. Li, S. Achilefu, Y. Gu: Gold nanoparticles based molecular beacons for in vitro and in vivo detection of the matriptase expression on tumor. Biosens Bioelectron 49 216-221 (2013)
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13. H. Lee, M.Y. Berezin, R. Tang, N. Zhegalova, S. Achilefu: Pyrazole-substituted near-infrared cyanine dyes exhibit pH-dependent fluorescence lifetime properties. Photochem Photobiol 89 326-331 (2013)
14. J. Xue, L. Shan, H. Chen, Y. Li, H. Zhu, D. Deng, Z. Qian, S. Achilefu, Y. Gu: Visual detection of STAT5B gene expression in living cell using the hairpin DNA modified gold nanoparticle beacon. Biosens Bioelectron 41 71-77 (2012)
15. S. Cui, D. Yin, Y. Chen, Y.Di, H. Chen, Y. Ma, S. Achilefu, Y. Gu: In vivo targeted deep-tissue
photodynamic therapy based on near-infrared light triggered upconversion nanoconstruct. ACS Nano 7 676-688 (2013)
16. X. Xu, P. Sarder, N. Kotagiri, S. Achilefu, A. Nehorai: Performance analysis and design of position-encoded microsphere arrays using the ziv-zakai bound. IEEE Trans Nanobioscience 12 29-40 (2013)
17. M. Solomon, R. E. Nothdurft, W. Akers, W.B. Edwards, K. Liang, B. Xu, G.P. Sudlow, H. Deghani, Y. C. Tai, A.T. Eggebrecht, S. Achilefu, J. Culver: Multimodal fluorescence-mediated tomography and SPECT/CT for small-animal imaging. J. Nucl Med 54 639-646 (2013)
18. D. Deng, J. Cao, L. Qu, S. Achilefu, Y. Gu: Highly luminescent water-soluble quaternary Zn-Ag-In-S quantum dots for tumor cell-targeted imaging. Phys Chem Chem Phys 15 5078-5083 (2013)
19. Z. Wang, K. Zhang, Y. Shen, J. Smith, S. Bloch, S. Achilefu, K.L. Wooley, J.S. Taylor: Imaging
mRNA expression levels in living cells with PNA-DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles. Org Biomol Chem 11 3159-3167 (2013)
20. T.P. Gustafson, S. A. Dergunov, W.J. Akers, Q. Cao, S. Magalotti, S. Achilefu, E. Pinkhassik, M.Y. Berezin: Blood triggered rapid release porous nanocapusles. RSC Adv 16 5547-5555 (2013)
21. Y. Liu, R. Njuguna, T. Matthews, W.J. Akers, G.P. Sudlow, S. Mondal, R. Tang, V. Gruev, S. Achilefu: Near-infrared fluorescence goggle system with complementary metal-oxide-semiconductor imaging sensor and see-through display. J Biomed Opt 18 101303 (2013)
22. S. T. Wang, N.G. Zhegalova, T.P. Gustafson, A. Zhou, J. Sher, S. Achilefu, O.Y. Berezin, M.Y. Berezin: Sensitivity of activatable reactive oxygen species probes by fluorescence spectroelectrochemistry. Analyst 138 4363-4369 (2013)
23. J. Cao, S., Huang, Y. Chen, S. Li, S. Achilefu, Z. Qian, Y. Gu: Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release. Proc. of SPIE. 8596 859606 (2013)
24. K. Guo, N. Zhegalova, S. Achilefu, M.Y. Berezin: Bloodstain age analysis: Toward solid
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state fluorescent lifetime measurements. Proc. of SPIE. 8572 (2013)
25. S Li., J. Cao, J. Qin X. Zhang, S. Achilefu, Z. Qian, Y. Gu: Docosahexaenoic acid conjugated near infrared fluorescence probe for in vivo early tumor diagnosis. Proc. of SPIE. 8596 859613 (2013)
26. Y. Pu, R. Tang, J. Xue, W.B Wang, B. Xu, D. Shen, S. Bloch, M. Zhou, S. Achilefu, R.R. Alfano: Synthesize dye-bioconjugates to visualize cancer cells using fluorescence microscopy. Proc. of SPIE. 8587 ( 2013)
27. Y. Pu, W.B. Wang, G.C. Tang, K. Liang, S. Achilefu, R.R. Alfano: Near infrared spectral polarization imaging of prostate cancer tissues using Cybesin: A receptor-targeted contrast agent. Proc. of SPIE. 8565 85651G (2013)
28. Y. Pu, J. Xue, B. Xu, W. Wang, Y. Gu, R. Tang, S. Achilefu, E. Ackerstaff, J.A. Koutcher, R.R. Alfano: Investigation of native fluorescence spectral difference among prostate cancer cell lines with different risk levels. Proc. of SPIE. 8577 85770X (2013)
29. L.A. Sordillo, B.B. Das, Y. Pu, K. Liang, G. Milione, P.P. Sordillo, S. Achilefu, R.R.Alfano: Time-resolved fluorescence for breast cancer detection using an octreotate-indocyanine green derivative dye conjugate. Proc. of SPIE. 8577 857708 (2013)
30. X. Xu, Z. Li, N. Kotagiri, P. Sarder, S. Achilefu, A. Nehorai: Microfluidic microsphere-trap arrays for simultaneous detection of multiple targets. Proc. of SPIE 8615 86151E (2013)
31. J. Zhao, Y. Ma, S. Cui, J. Cao, S. Achilefu, Y. Gu: MUC1 aptamer based near infrared fluorescence probes for tumor diagnosis. Proc. of SPIE. 8596 859614 (2013)
2012
32. H. Chen, S. Li, B. Li, X. Ren, S. Li, D.M. Mahounga, S. Cui, Y. Gu, S. Achilefu: Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy. Nanoscale 4 6050-6064 (2012)
33. R. Tang, H. Lee, S. Achilefu: Induction of pH sensitivity on the fluorescence lifetime of quantum dots by NIR fluorescent dyes. J Am Chem Soc 134 4545-4548 (2012)
34. W.J. Akers, W.B.Edwards, C. Kim, B. Xu, T.N. Erpelding, L.V. Wang, S. Achilefu: Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography. Transl Res 159 175-181 (2012)
35. S.W. Tsen, T. Chapa, W. Beatty, K.T. Tsen, D. Yu, S. Achilefu: Inactivation of enveloped virus by laser-driven protein aggregation. J. Biomed Opt 17 128001-8 (2012)
36. X. Xu, P. Sarder, N. Kotagiri, S. Achilefu, A. Nehorai: Performance analysis and design of position-encoded microsphere arrays using the ziv-zakai bound. IEEE Trans Nanobioscience (2012 )
37. Y. Liu, T. York, W. Akers, G. Sudlow, V. Gruev, S. Achilefu: Complementary fluorescence-polarization microscopy using division-of-focal-plane polarization imaging sensor. J Biomed Opt 17 116001- 4 (2012)
38. M. Xu, M. Rettig, G. Sudlow, B. Wang, W. Akers, D. Cao, D. Mutch, J. Dipersio, S. Achilefu:
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Preclinical evaluation of mab CC188 for ovarian cancer imaging. Int J Cancer 131 1351-1359 (2012)
39. H. Lee, M.Y. Berezin, R. Tang, N. Zhegalova, S. Achilefu: Pyrazole-substituted near-infrared cyanine dyes exhibit pH-dependent fluorescence lifetime properties. Photochem Photobiol doi: 10.1111/php.12009 (2012)
40. J. C. Gildersleeve, B. Wang, S. Achilefu, Z. Tu, M. Xu: Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies. Bioorg Med Chem Lett 22 6839-6843 (2012)
41. Y. Ye, W. J. Akers, B. Xu, S. Bloch, C. Odonkor, S. Achilefu: Near-infrared fluorescent divalent RGD ligand for integrin avb3-targeted optical imaging. Bioorg Med Chem .Lett 22 5405-5409 (2012)
42. V. Korotcov, Y. Yunpeng, Y. Chen, F. Zhang, S. Huang, S. Lin, R. Sridhar, S. Achilefu, P.C. Wang: Glucosamine-linked near infrared fluorescent probes for imaging of solid tumor xenografts. Mol Imag Biol 14 443-451 (2012)
43. J. Guo, C. Du, L. Shan, H. Zhu, B. Xue, Z. Qian, S. Achilefu, Y. Gu: Comparison of near-infrared fluorescent deoxyglucose probes with different dyes for tumor diagnosis in vivo. Contrast Media Mol Imaging 7 289-301 (2012)
44. H. Li, Z. Tu, L. An, Z. Qian, S. Achilefu, Y. Gu: Inhibitory effects of ER β on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells-prognostication for the use of ER β –selective therapy. Pharm Biol 50 839-49 (2012)
45. Z. Tu, H. Li, Y. Ma, B. Tang, J. Tian, W. Akers, S. Achilefu, Y. Gu: The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression. Mol Cell Biochem 366 111-122 (2012)
46. B. Xue, D. Deng, J. Cao, F. Liu, X. Li, W. Akers, S. Achilefu, Y. Gu: Synthesis of NAC capped near infrared-emitting CdTeS alloyed quantum dots and application for in vivo early tumor imaging. Dalton Trans., 41 4935-4947 (2012)
47. Z. Tu, Y. Ma, J. Tian, H. Li, W. Akers, S. Achilefu, Y. Gu: Estrogen receptor β potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells. J Cancer Res Clin Oncol 138 1091-1103 (2012)
48. S. Achilefu: Rapid response activatable molecular probes for intraoperative optical image guided tumor resection. Hepatology 56 1170-3 (2012)
49. Y. Ardeshirpour, V. Chernomordik, R. Zielinski, J. Capala, G. Griffiths, O. Vasalatiy, A.V. Smirnov, J.R. Knutson, I. Lyakhov, S. Achilefu, A. Gandjbakhche, M. Hassan: In vivo fluorescence lifetime imaging monitors binding of specific probes to cancer biomarkers. PLoS One 7 1-14 (2012)
50. J. Wang, J. Moore, S. Laulhe, M. Nantz, S. Achilefu, K.A. Kang: Fluorophore-gold nanoparticle complex for sensitive optical biosensing and imaging. Nanotechnology 23 1-13 (2012)
51. W.J. Akers, B. Xu, H. Lee, G. Sudlow, G.B. Fields, S. Achilefu, W.B. Edwards: Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe.
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Bioconjug Chem 3 656-663 (2012)
52. T.P. Gustafson, Q. Cao, S. Achilefu, M.Y. Berezin: Defining a polymethine dye for fluorescence anisotropy applications in the near-infrared spectral range. Chemphyschem 13 716-723 (2012)
53. J.M. Craft, R.A. De Silva, K.A. Lears, R. Andrews, K. Liang, S. Achilefu, B.E. Rogers: In vitro and in vivo evaluation of a (64)Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer. Nucl Med Biol. 39 609-616 (2012)
54. K.A. Kang, J. Wang, M.G. O’Toole, M. Nantz, J.D. Moore, S. Laulhe, S. Achilefu: Sensitivity enhancement of NIR fluorescence contrast agent utilizing gold nanoparticles. Adv Exp Med Biol. 737, 285-291 (2012)
55. K. Guo, S. Achilefu, M.Y. Berezin: Dating bloodstains with fluorescence lifetime measurements. Chem. Eur. J. 18 1302-1305 (2012)
56. L. Shan, S. Cui, C. Du, S. Wan, Z. Qian, S. Achilefu, Y. Gu: A paclitaxel-conjugated adenovirus vector for targeted drug delivery for tumor therapy. Biomaterials 33 146-162 (2012)
57. Y. Liu, A.Q. Bauer, W. Akers, G. Sudlow, K. Liang, T. Charanya, S. Mondal, J.P. Culver, S. Achilefu: Fluorescence goggle for intraoperative breast cancer imaging. Proc of SPIE 8215 82150G-1 (2012)
58. Y. Pu, W. Wang, G. Tang, Y. Budansky, M. Sharonov, M. Xu, S. Achilefu, J.A. Eastham, R.R. Alfano: Screening prostate cancer using a portable near infrared scanning imaging unit with an optical fiber based rectal probe. Proc of SPIE 8220 822002-1 (2012)
59. W.J. Akers, M. Solomon, G.P. Sudlow, M. Berezin, S. Achilefu: Time domain imaging with quench based fluorescent contrast agents. Proc of SPIE 8233 82330G-1
60. M. Shokeen, E. Pressly, C. Luke, L. Yongjian, C. J. Hawker, P.K. Woodard, C.J. Anderson, S. Achilefu, M.J. Welch: Multi modal in cellulo evaluation of NPR-C targeted C-ANF-peptide and C-ANF-comb nanoparticles. Proc of SPIE 8233 82330U-1 (2012)
61. R. Nothdurft, P. Sarder, S. Bloch, J. Culver, S. Achilefu: Fluorescence lifetime imaging microscopy using near-infrared contrast agents. J. Microsc. 247 202-7 (2012)
62. X. Zhang, S. Bloch, W. Akers, S. Achilefu: Near-infrared molecular probes for in vivo imaging. Curr Protoc Cytom 12.27.1-20 (2012)
2011
63. M. Solomon, B.R. White, R.E. Nothdurft, W. Akers, G. Sudlow, A.T. Eggebrecht, S. Achilefu, J.P. Culver: Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging. Biomed Opt Express 12 3267-77 (2011)
64. Y. Ardeshirpour, V. Chernomordik, J. Capala, M. Hassan, R. Zielinsky, G. Griffiths, S. Achilefu, P. Smith, A. Gandjbakhche: Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm. Technol
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Cancer Res Treat 10 505-634 (2011)
65. Y. Pu, W. B. Wang, M. Xu, G.C. Tang, Y. Budansky, M. Sharanov, S. Achilefu, J.A. Eastham, R. R. Alfano: Near infrared photonic finger imager for prostate cancer screening. Technol Cancer Res Treat 10, 507-517 (2011)
66. V. Korotcov, Y. Ye, Y Chen, F. Zhang, S. Huang, S. Lin, R. Sridhar, S. Achilefu, P. C. Wang: Glucosamine-linked near-infrared fluorescent probes for imaging of solid tumor xenografts. Mol Imaging Biol 14 443-451 (2011)
67. S. Basak, V. Tiwari, J. Fan, S. Achilefu, V. Sethi, P. Biswas: Single step aerosol synthesis of nanocomposites by aerosol routes: γ- Fe2O3/SiO2 and their functionalization. J. Mater. Res. 26 (2011)
68. M.Y. Berezin, C. Zhan, H. Lee, C. Joo, W.J.Akers, S. Yazdanfar, S. Achilefu: Two-photon optical properties of near-infrared dyes at 1.55 microns excitation: J. Phys. Chem. B, 115 11530-11535 (2011)
69. M. Solomon, Y. Liu, M.Y. Berezin and S. Achilefu: Optical imaging in cancer research: Basic principles, tumor detection, and therapeutic monitoring. Med Princ Pract 20 397-414 (2011)
70. M. Solomon, K. Guo, G.P. Sudlow, M.Y. Berezin, W.B. Edwards, S. Achilefu, W.J. Akers: Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe. J. Biomed. Opt 6 066019 (2011)
71. K. A. Kang, J. Wang, J.B. Jasinski, S. Achilefu: Fluorescence manipulation by gold nanoparticles: From complete quenching to extensive enhancement. J. Nanobiotechnology 9:16 (2011)
72. J. Wang, S. Achilefu, M. Nantz, K.A. Kang: Gold nanoparticle-fluorophore complex for conditionally fluorescing signal mediator. Analytica Chimica Acta 695 96-104 (2011)
73. Y. Liu, A.Q. Bauer, W.J. Akers, G. Sudlow, K. Liang, D. Shen, M.Y. Berezin, J. P. Culver, S. Achilefu: Hands-free, wireless goggles for near-infrared fluorescence and real-time image-guided surgery. Surgery 149 689-98 (2011)
74. M. Bai, S. Achilefu: Synthesis of functional near infrared pyrrolopyrrole cyanine dyes for optical and photoacoustic imaging. Heterocycl. Commmum. 16 213-216 (2011)
75. M. Y. Berezin, K. Guo, W. Akers, R. E. Nothdurft, J.P. Culver, B. Teng, O. Vasalatiy, K. Barbacow, A. Gandjbakhche, G. L. Griffiths, S. Achilefu: Near-infrared fluorescence lifetime pH-sensitive probes. Biophys J 100 2063-2072 (2011)
76. W.J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G.M. Lanza, G.M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L.V. Wang, S. Achilefu: Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. ACS Nano 5 173-82 (2011)
77. J. Wang, M. O’Toole, A. Massey, S. Biswas, M. Nantz, S. Achilefu, K.A. Kang: Highly specific, NIR fluorescent contrast agent with emission controlled by gold nanoparticle. Adv. Exp. Med. Biol. 915 149-54 (2011)
78. Y. Pu, W.B. Wang, S. Achilefu, R. R. Alfano: Study of rotational dynamics of receptor-targeted contrast agents in cancerous and normal prostate tissues using time-
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resolved picosecond emission spectroscopy. Appl. Opt. 10 1312-22 (2011)
79. L. Shan, J. Xue, J. Guo, Z. Qian, S. Achilefu, Y. Gu: Improved Targeting of Ligand-Modified Adenovirus as a New Near Infrared Fluorescence Tumor Imaging Probe. Bioconjug Chem 4 567-581 (2011)
80. H. Lee, W. Akers, K. Bhushan, S. Bloch, G. Sudlow, R. Tang, S. Achilefu: Near-infrared pH-activatable fluorescent probes for imaging primary and metastatic breast tumors Bioconjug Chem 22 777-784 (2011)
81. Y. Ye, B. Xu, GV. Nikiforovich, S. Bloch, S. Achilefu: Exploring new near-infrared fluorescent disulfide-based cyclic RGD peptide analogs for potential integrin-targeted optical imaging. Bioorg Med Chem Lett. 21 2116-20 (2011)
82. M.Y. Berezin, K. Guo, W. Akers, J. Livingston, M. Solomon, H. Lee, K. Liang, A. Agee, S. Achilefu: Rational approach to select small peptide molecular probes labeled with fluorescent cyanine dyes for in vivo optical imaging. Biochemistry 50 2691-2700 (2011)
83. W. Li, X. Cai, C. Kim, G. Sun, Y. Zhang, R. Deng, M. Yang, J. Chen, S. Achilefu, L.V. Wang, Y. Xia: Gold nanocages covered with thermally-responsive polymers for controlled release by high-intensity focused ultrasound. Nanoscale 3 1724-1730 (2011)
84. K.A. Lears, R. Ferdani, K. Liang, A. Zheleznyak, R. Andrews, C.D. Sherman, S. Achilefu, C.J. Anderson, B.E. Rogers: In vitro and in vivo evaluation of 64Cu-labeled sarAr-bombesin analogs in gastrin-releasing peptide receptor-expressing Prostate Cancer. J Nucl Med. 52 470-7. (2011)
85. Y. Liu, A.Q. Bauer, W. J. Akers, G. Sudlow, K. Liang, D. Shen, M. Berezin, J.P. Culver, S. Achilefu: Compact intraoperative imaging device for sentinel lymph node mapping. Proc. of SPIE 7910 79100D-1 (2011)
86. C. Kim, T.N. Erpelding, W.J. Akers, K. Maslov, L. Song, L. Jankovic, J. A. Margenthaler, S. Achilefu, L. V. Wang: Photoacoustic image-guided needle biopsy of sentinel lymph nodes. Proc of SPIE 7899 78990K-1 (2011)
87. Y. Pu, W.B. Wang, G.C. Tang, S. Achilefu, R.R. Alfano: Time-resolved spectroscopy and near infrared imaging enhanced by receptor targeted contrast agents for prostate cancer detection. Proc of SPIE 7895 78950B-1 (2011)
88. H.S. de Bruijn, S. Kašáková, L.J. Hofland, A. van der Ploeg-van den Heuvel, Y. Ye, S. Achilefu, H.J.C.M. Sterenborg, T.L.M. ten Hagen, P.M. van Hagen, and D.J. Robinson: In vitro and in vivo SST2 receptor targeted photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 8(2), 195 (2011)
89. K. Guo, F. Lin, W. Akers, J. Zheng, B. Teng, O. Vasalatiy, G. L. Griffiths, A. Gandjbakhche, M.Y. Berezin, S. Achilefu: Novel design of multimodal MRI/NIR optical contrast agent. Proc of SPIE 7910 791015-1 (2011)
90. M. Bai, S. Achilefu: Synthesis and spectroscopy of near infrared fluorescent dyes for investigation dichromic fluorescence. Bioorg Med Chem Lett 21 208-284 (2011)
2010
91. S. Achilefu: The insatiable quest for near infrared fluorescent probes for molecular
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imaging. Angew Chem Int Ed 49 9816-9818 (2010)
92. Y. Liu, M. Solomon, S. Achilefu: Perspectives and potential applications of nanomedicine in breast and prostate cancer. Med Res Rev 33 3-32 (2010)
93. C. Kim, T.N. Erpelding, K. Maslov, L. Jankovic, W.J. Akers, L. Song, S. Achilefu, J.A. Margenthaler, M.D. Pashley, L.V. Wang: Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes. J. Biomed Optics 15 046010-4 (2010)
94. W.J Akers, Z. Zhang, M. Berezin, Y. Ye, A. Agee, K. Guo, R.W. Fuhrhop, S.A. Wickline, G.M. Lanza, S. Achilefu: Targeting of ανβ3-integrins expressed on tumor tissue and neovasculature using fluorescent small molecules and nanoparticles. Nanomedicine 5 715-726 (2010)
95. S. Yazdanfar, C. Joo, C. Zhan, M.Y. Berezin, W. J. Akers, S. Achilefu: Multiphoton microscopy with near infrared contrast agents. J. Biomed Optics 15 030505-3 (2010)
96. K. Guo, M.Y. Berezin, J. Zheng, W. Akers, F. Lin, B. Teng, O. Vasalatiy, A. Gandjbakhche, G.L. Griffiths, S. Achilefu: Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging. Chem. Commun., 46 3705-3707
97. T. -C. Yen, S.-P. Wey, C.-H Liao, C.-H. Yeh, D.-W. Shen, S. Achilefu, T.-C. Wun: Measurement of the binding parameters of annexin derivative–erythrocyte membrane interactions. Anal. Biochem. 406 70-79 (2010)
98. S. Achilefu: Introduction to concepts and strategies for molecular imaging. Chem Reviews 110 2575-2578 (2010)
99. M.Y. Berezin, S. Achilefu: Fluorescence lifetime measurements and biological imaging. Chem Reviews, 110 2641-2684 (2010)
100. G. Sun, M.Y. Berezin, J. Fan, H. Lee, J. Ma, K. Zhang, K.L. Wooley, S. Achilefu: Bright fluorescent nanoparticles for developing potential optical imaging contrast agents. Nanoscale, 2 548-558 (2010)
101. F. Liu, D. Deng, X. Chen, Z, Qian, S. Achilefu, Y. Gu: Folate-polyethylene glycol conjugated near-infrared fluorescence probe with high targeting affinity and sensitivity for In vivo early tumor diagnosis. Mol Imaging Biol 12 595-607 (2010)
102. J. Wang, M H. Nantz, S. Achilefu, K. A. Kang: FRET-like fluorophore-nanoparticle complex for highly specific cancer localization. Adv Exp Med Biol. 662 407-413 (2010).
103. Z. Zhang, J. Kao, A. D ‘Avignon, S. Achilefu: Understanding dichromic fluorescence manifested in certain Indocyanine green (ICG) analogs. Pure Appl. Chem. 82 307-311 (2010)
104. B. A. Smith, W.J. Akers, W. M. Leevy, A.J. Lampkins. S. Xiao, W. Wolter, M. A. Suckow, S. Achilefu, B.D. Smith: Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc (II)-dipicolylamine probe for anionic cell surfaces. J. Am. Chem. Soc. 132 67-69 (2010)
105. R. Chen, J.J. Parry, W.J. Akers, M.Y. Berezin, I.M. El Naqa, S. Achilefu, W.B. Edwards, B.E. Rogers: Multimodality imaging of gene transfer with a receptor-based reporter gene. J Nucl Med., 51 1456-1463 (2010)
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106. M. Xu, F. Wang, J.C. Gildersleeve, S. Achilefu: MAb L9E10 to blood group H2 antigen binds to colon cancer stem cells and inhibits tumor cell migration and invasion. Hybridoma, 29 355-359 (2010)
107. Y. Gu, G. Liu, C. Fang, Z. Qian, S. Achilefu: In vivo investigation of pharmacokinetics of model drug: comparison of near infrared technique with high-performance liquid chromatography. Proc. of SPIE 7576 7570A-1 (2010)
108. C. Zhan, C. Joo, Q. Li, M.Y. Berezin, W.J. Akers, Y. Ye, S. Achilefu, S. Yazdanfar: Multimodal Nonlinear Microscopy at 1.5 μm. Proc. of SPIE 7569 75691Z-1 (2010)
109. Y. Pu, W.B. Wang, S. Achilefu, R.R. Alfano: Rotational dynamics and polarization anisotropy of bound and unbound receptor-targeted contrast agents in cancerous and normal prostate tissues studied by time-resolved fluorescence spectroscopy. Proc. of SPIE 7561 75610A-1 (2010)
110. W. J. Akers, M.Y. Berezin, H. Lee, K. Guo, A. Almutairi, J.M.J. Fréchet, G. M. Fischer, E. Daltrozzo, S. Achilefu: Biological applications of fluorescence lifetime imaging beyond microscopy. Proc. of SPIE 7576 757612-1 (2010)
111. M. Ptaszek, H. L. Kee, C. Muthiah, R. Nothdurft, W. J. Akers, S. Achilefu, J.P. Culver, D. Holten: Near-infrared molecular imaging probes based on chlorin-bacteriochlorin dyads. Proc. of SPIE 7576 75760E-1 (2010)
112. M.Y. Berezin, K. Guo, H. Lee, W.J. Akers, A. Almutairi, J.M.J. Fréchet, S. Achilefu: Strategies for Developing pH Sensitive Fluorescent Probes. Proc. of SPIE 7576 75760F-1 (2010)
2009
113. M.Y. Berezin, H. Lee, W. J. Akers, K. Guo, R.J. Goiffon, A. Almutairi, J.M.J. Fréchet, S. Achilefu: Engineering NIR dyes for fluorescent lifetime contrast. 31st Annual International Conference of the IEEE EMBS 114- 117 (2009)
114. M.Y. Berezin, W. J. Akers, K. Guo, G.M. Fischer, E. Daltrozzo, A. Zumbusch, S. Achilefu: Long fluorescence lifetime molecular probes based on near infrared Pyrrolopyrrole cyanine fluoropores for in vivo imaging. Biophys. J. 97 L22-L24 (2009)
115. M.Y. Berezin, K. Guo, B. Teng, W.B. Edwards, C. J. Anderson, O. Vasalatiy, A. Gandjbakhche, G. L. Griffiths, S. Achilefu: Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye. J.AM. Chem Soc. 131, 9198-9200 (2009)
116. H. Lee, W.J. Akers, P.P. Cheney, W. B. Edwards, K. Liang, J.P. Culver, S. Achilefu: Complementary optical and nuclear imaging of caspase-2 activity using combined activatable and radiolabeled multimodality molecular probe. J. Biomed Optics 14 040507-3 (2009)
117. R. E. Nothdurft, S.V. Patwardhan, W. Akers, Y. Ye, S. Achilefu, J.P. Culver: In vivo fluorescence lifetime tomography. J. Biomed Optics 14, 024004-7 (2009)
118. R.J. Goiffon, W.J. Akers, M.Y. Berezin, H. Lee, S. Achilefu: Dynamic noninvasive monitoring of renal function in vivo by fluorescence lifetime imaging. J Biomed Optics 14, 020501-3 (2009)
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119. H. Lee, M.Y. Berezin, K. Guo, J. Kao, S. Achilefu: Near-infrared fluorescent pH-sensitive probes via unexpected barbituric acid mediated synthesis. Org. Lett. 11, 29-32 (2009)
120. W. B. Edwards, W.J. Akers, Y.Ye, P.P. Cheney, S. Bloch, B. Xu, R. Laforest, S. Achilefu: Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide. Mol Imaging 8, 101-10 (2009)
121. L. Wei, Y. Ye, T.J. Wadas, J. S. Lewis, M.J. Welch, S. Achilefu, C.J. Anderson: 64 Cu-Labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity. Nucl Med Biol. 36, 277-285 (2009)
122. Z. Zhang, J. Fan, P.P. Cheney, M.Y. Berezin, W.B. Edwards, W.J. Akers, D. Shen, K. Liang, J.P. Culver, S. Achilefu: Activatable molecular systems using homologous near-infrared fluorescent probes for monitoring enzyme activities in vitro, in cellulo and in vivo. Mol.Pharm 6, 416-427 (2009)
123. M.Y. Berezin, J. Kao, S. Achilefu: pH dependent optical properties of synthetic fluorescent imidazoles. Chem. Eur. J 15, 3560-3566 (2009)
124. K. Hsu, J. Pratt, W.J. Akers, S. Achilefu, W.M. Yokoyama: Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. J. Gen. Virol. 90, 33-43 (2009)
125. C. Odonkor, S. Achilefu: Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy. Cancer Invest. 27, 417-429 (2009)
126. H. Qian, Y. Gu, M. Wang, S. Achilefu: Optimization of the near infrared fluorescence labeling for in vivo monitoring of a protein drug distribution in animal model. J. Fluoresc 19 277-284 (2009)
127. W. J. Akers, M.Y. Berezin, H. Lee, S. Achilefu: In Vivo Imaging with Near-infrared Fluorescence Lifetime Contrast. Proc. of SPIE 7190 71900T-1 (2009)
128. P.P. Cheney, G.B. Fields, S. Achilefu, W.B. Edwards: Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging. Proc. of SPIE 7190 719011-1 (2009)
2008
129. M. Xu, Y.Yuan, Y. Xia, S. Achilefu: Monoclonal antibody CC188 binds a carbohydrate epitope expressed on the surface of both colorectal cancer stem cells and their differentiated progeny. Clin. Cancer Res. 14, 7461-7469 (2008)
130. T.J. Wadas, M. Eiblmaier, A. Zheleznyak, C.D. Sherman, R. Ferdani, K. Liang, S. Achilefu, C.J. Anderson: Preparation and biological evaluation of 64Cu-CB-TE2A-sst-ANT, a somatostatin antagonist for PET imaging of somatostatin receptor-positive tumors. J. Nucl. Med. 49, 1819-1827 (2008)
131. Z. Zhang, M.Y. Berezin, J.L.F. Kao, A. Avignon, M. Bai, S. Achilefu: Near-infrared dichromic fluorescent carbocyanine molecules. Angew.Chem. Int. Ed 47, 1-5 (2008)
132. Almutairi, S.J. Guillaudeu, M.Y. Berezin, S. Achilefu, J.M. Fréchet: Biodegradable pH-
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Sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging. J. Am. Chem. Soc. 130, 444-445 (2008)
133. J. Culver, W. Akers, S. Achilefu: Multimodality molecular imaging with combined optical and SPECT/PET modalities. J. Nucl. Med. 49, 169-172 (2008)
134. W. Akers, M.Y. Berezin, H. Lee, S. Achilefu: Predicting in vivo fluorescence lifetime behavior of near-infrared fluorescent contrast agents using in vitro measurements. J Biomed. Optics 13, 054042 (2008)
135. Almutairi, W. J. Akers, M.Y.Berezin, S. Achilefu, J.M. Fréchet: Monitoring the biodegradation of dendritic near-infrared nanoprobes by in vivo fluorescence imaging. Mol. Pharm. 5, 1103-1110 (2008)
136. Odonkor, S. Achilefu: Differential activity of Caspase-3 regulates susceptibility of lung and breast cancer tumor cell lines to paclitaxel. Open Biochem. J. 2, 121-128 (2008)
137. T. O. Hirche, R. Benabid, G. Deslee, S. Gangloff, S. Achilefu, M. Guenounou, F. Lebargy, R.E. Hancock, A Belaaouaj: Neutrophil elastase mediates innate host protection against Pseudomonas aeruginosa. J. Immunol. 181, 4945-4954 (2008)
138. H. Lee, M.Y. Berezin, M. Henary, L. Strekowski, S. Achilefu: Fluorescence lifetime properties of near-infrared cyanine dyes in relation to their structures. J. Photochem. & Photobiol. A 200, 438-444 (2008)
139. Y. Pu, W.B. Wang, B.B. Das, S. Achilefu, R.R . Alfano: Time-resolved fluorescence polarization dynamics and optical imaging of cytate: a prostate cancer receptor-targeted contrast agent. Applied Optics 47, 2281-2289 (2008)
140. H. Lee, J.C. Mason, S. Achilefu: Synthesis and spectral properties of near-infrared aminophenyl- hydroxyphenyl-and phenyl-substituted heptamethine cyanines. J. Org. Chem. 73, 723-725 (2008)
141. Y. Ye, S. Bloch, B. Xu, S. Achilefu: Novel near-infrared fluorescent integrin-targeted DFO analogue. Bioconjug. Chem. 19, 225-234 (2008)
142. W.B. Edwards, B. Xu, W. Akers, P.P. Cheney, K. Liang, B.E. Rogers, C.J. Anderson, S. Achilefu: Agonist-antagonist dilemma in molecular imaging: evaluation of a monomolecular multimodal imaging agent for the somatostatin receptor. Bioconjug. Chem. 19 192-200 (2008)
143. M. Y. Berezin, H. Lee, W. J. Akers, G. Nikiforovich, S. Achilefu: Fluorescent lifetime of near infrared dyes for structural analysis of serum albumin. Proc. of SPIE 6867 68670J-1(2008)
2007
144. S. Achilefu: Biophotonics-Unravelling animal anatomy. Nature Photonics, 1, 496-497 (2007)
145. M.Y. Berezin, H. Lee, W. Akers, S. Achilefu: Near Infrared dyes as lifetime solvatochromic probes for micropolarity measurements of biological systems. Biophys. J. 93, 2892-2899 (2007)
146. M.Y. Berezin, H. Lee, W. Akers, G. Nikiforovich, S. Achilefu: Ratiometric analysis of fluorescence lifetime for probing binding sites in albumin with near infrared
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fluorescent molecular probes. Photochem. Photobiol. 83, 1371-1378 (2007)
147. W. Akers, F. Lesage, D. Holten, S. Achilefu: In vivo resolution of multiexponential decays of multiple near-infrared molecular probes by fluorescence lifetime-gated whole-body time-resolved diffuse optical imaging. Mol Imaging, 6, 237-246 (2007)
148. G.V. Nikiforovich, G.R. Marshall, S. Achilefu: Molecular modeling suggests conformational scaffolds specifically targeting five subtypes of somatostatin receptors. Chem Biol Drug Des. 69, 163-169 (2007)
149. M. Berezin, S. Achilefu: Novel synthon for incorporating 1,3-dimethyl imidazolium group into molecular architecture. Tetrahedron Lett. 48, 1195-1199 (2007)
150. D. Shen, K. Liang, Y. Ye, E.Tetteh, S. Achilefu: Modulation of nuclear internalization of Tat peptides by fluorescent dyes and receptor-avid peptides. FEBS Lett. 581, 1793-1799 (2007)
151. J.E. Sprague, H. Kitaura, W. Zou, Y. Ye, S. Achilefu, K.N. Weilbaecher, S.L.Teitelbaum, C.J. Anderson: Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide. J Nucl Med. 48, 311-318 (2007)
152. Y. Pu, W.B. Wang, S. Achilefu, B.B. Das, G.C. Tang, V. Sriramoju, R.R. Alfano: Time-resolved fluorescence polarization anisotropy and optical imaging of Cybesin in cancerous and normal prostate tissues. Optics Commun. 274, 260-267 (2007)
153. W. Akers, S. Achilefu: In vivo resolution of two near-infrared fluorophores by time-domain diffuse optical imaging. Proc SPIE 6449, 6449H1-8 (2007)
2006
154. S. Bloch, B. Xu, Y. Ye, K. Liang, G. V. Nikiforovich, S. Achilefu: Targeting Beta-3 Integrin using a Linear Hexapeptide Labeled with a Near Infrared Fluorescent Molecular Probe. Mol. Pharm. 3, 539-549 (2006)
155. Y. Ye, S. Bloch, B. Xu, S. Achilefu: Design, synthesis, and evaluation of novel fluorescent multimeric RGD peptides for tumor targeting. J. Med. Chem. 49, 2268-2275 (2006)
156. J. E. Sprague, W. P. L, K. Liang, S. Achilefu, C. J. Anderson: Molecular Imaging of Matrix Metalloproteinase Expression in Metastatic Tumor Models. Nuclear Med. Biol. 32, 227-237 (2006)
157. H. Lee, J. C. Mason, S. Achilefu: Heptamethine Cyanine Dyes with Robust C-C Bond at the Central Position of Chromophore. J. Org. Chem. 71, 7862-7865 (2006)
158. Y. Ye, B. Xu, S. Bloch, S. Achilefu: Synthesis, metal coordination, and cellular internalization of a siderophore-bearing NIR fluorescent carbocyanine probe. Proc. SPIE 6097, 609701-5 (2006)
159. W.B. Edwards, K. Liang, B. XU, C.J. Anderson, S. Achilefu: Synthesis and radiolabeling of a somatostatin analog for multimodal imaging. Proc. SPIE 6097, 6097031-8 (2006)
160. D. Shen, K. Liang, Y.Ye, E. Tetteh, S. Achilefu: Preliminary study on the inhibition of nuclear internalization of Tat peptides by conjugation with a receptor-specific peptide and fluorescent dyes. Proc. SPIE 6097, 6097041-9 (2006)
161. Y. Ye, S. Bloch, B. Xu, S. Achilefu: Synthesis and evaluation of two NIR fluorescent cyclic
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RGD penta-peptides for targeting integrins. Proc. SPIE 6097, 6097071-7 (2006)
162. Z. Zhang, D. Shen, K. Liang, S. Achilefu: Design, synthesis, and evaluation of near-infrared fluorescent pH indicators at physiological range. Proc SPIE 6097, 609701-6 (2006)
163. S. Bloch, B. Xu, Y. Ye, K. Liang, S. Achilefu: Internalization of RGD peptide conjugates of near-infrared fluorescent probes in different cell lines occurs via different integrin receptor subtypes. Proc. SPIE 6097, 609701-9 (2006)
2005
164. S. Achilefu, S. Bloch, M. A. Markiewicz, T. Zhong, Y. Ye, R. B. Dorshow, B. Chance, K. Liang: Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression. Proc Natl Acad Sci. 102,7976-7981 (2005)
165. S. Bloch, F. Lesage, L. McIntosh, A. Gandjbakhche, K. Liang, S. Achilefu: Whole-body fluorescence lifetime imaging of a tumor-targeted near infrared molecular probe in mice. J. Biomed. Optics 10, 054003 (2005)
166. Z. Zhang, K. Liang, S. Bloch, M. Berezin, S. Achilefu: Monomolecular multimodal fluorescence-radioisotope imaging agents. Bioconjugate Chem. 16, 1232-1239 (2005)
167. S. Achilefu, C. H. Contag, A. P. Savitsky, R. Weissleder: Chemical and Genetic Sensors in Biomedical Research. J. Biomed. Optics 10, 041201 (2005)
168. Y. Chen, A. Gryshuk, T. Ohulchansky, S. Achilefu, B. Zhou, W. Potter, J. Morgan, B. Chance, P. N. Prasad, A. Oserof, R. K. Pandey: HPPH-Cyanine Dye Conjugate - A Novel Bifunctional Agent for Tumor Diagnosis and Photodynamic Therapy. Bioconjugate Chem. 16, 1264-1274 (2005)
169. S.V. Patwardhan, S.R. Bloch, S. Achilefu, J.P. Culver: Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice. Optics Express, 13, 2564-2577 (2005)
170. Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, R. R. Alfano: Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent. Technol Cancer Res Treat. 4, 429-36 (2005)
171. Ye, S. Bloch, S. Achilefu: Multivalent Carbocyanine Molecular Probes: Synthesis and applications. Bioconjugate Chem. 16, 51-61 (2005)
172. Z. Zhang, S. Achilefu: Spectral properties of pro-multimodal imaging agents derived from a NIR dye and a metal chelator Photochem Photobiol. 81, 1499-1504 (2005)
173. Z. Zhang, S. Achilefu: Design, synthesis, and evaluation of near-infrared fluorescent pH indicators at physiologically relevant range. Chem. Comm. 47, 5887-5889 (2005)
2004
174. S. Achilefu: Lighting up tumors with receptor-specific optical molecular probes. Technol. Cancer Res. Treatment. 3, 393-410 (2004)
175. J.E. Sprague, Y. Peng, X. Sun, G.R. Weisman, E.H. Wong, S. Achilefu, C.J. Anderson:
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Preparation and biological evaluation of copper-64-labeled Tyr3-octreotate using a cross-bridged macrocyclic chelator. Clin. Cancer Res. 10, 8674-8682 (2004)
176. S. Achilefu: Optical imaging agents and potential application in the assessment of pancreatic beta cells. Curr. Med. Chem.- Immunology, Endocrine Metabolic Agents. 4, 253-270 (2004)
177. Y. Ye, S. Bloch, S. Achilefu: Polyvalent carbocyanine molecular beacons for molecular recognitions. J. Am. Chem. Soc. 126, 7740-7741 (2004)
178. S. Bloch, K. Liang, R.B. Dorshow, Y. Ye, S. Achilefu: Targeting expression of integrin receptors in tumors. Proc. SPIE.5329, 222-228 (2004)
179. Z. Zhang, S. Bloch, S. Achilefu: Synthesis and evaluation of novel galactose-carbocyanine fluorescent contrast agents with enhanced hydrophilicity and rigid molecular constraint. Proc. SPIE, 5329, 262-268 (2004)
180. Z. Zhang, S. Achilefu: Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes. Org. Lett. 6. 2067-2070 (2004)
2003
181. Y. Ye ,Li, C. J. Anderson, J. Kao, G. V. Nikiforovich, S. Achilefu: Synthesis and characterization of a macrocyclic near infrared optical scaffold. J. Am. Chem. Soc. 125, 7766-7767 (2003)
182. S. Achilefu, A. Srinivasan, M. A. Schmidt, H. N. Jimenez, J. E. Bugaj, J. L. Erion: Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors. J. Med. Chem. 46, 3403-3411 (2003)
183. V. A. Dalm, P. M. Van Hagen, P. M. Van Koetsveld, S. Achilefu, A. B. Houtsmuller, D. H. Pols, A. J. Van Der Lely, S. W. Lamberts, L. J. Hofland: Regulation of the expression of somatostatin, cortistatin and somatostatin receptors in human monocytes, macrophages and dendritic cells. Am. J. Physiol. Endocrinol. Metab.285, E344-E353 (2003)
184. Y. Chen, L. G. Zheng, Z. Zhang, D. Blessington, M. Zhang, Q. Liu, X. Intes, H. Li, S. Achilefu, and B. Chance: Metabolism enhanced tumor localization by fluorescence imaging – in vivo animal studies. Optics Letters 28, 2070-2072, (2003)
2002
185. J. S. Lewis, S. Achilefu, J. R. Garbow, R. Laforest, M. J. Welch: Small animal imaging: current technology and perspectives for oncological imaging. Eur. J. Cancer 38, 2173-2188 (2002)
186. Y. Chen, L. Zhou, C. Mu, I. Chenpeng, X. Intes, S. Achilefu, and B. Chance: Phase cancellation system for tumor imaging using targeted fluorescent contrast agents. Proc. SPIE-Int. Soc. Opt. Eng. 4916, 22-29 (2002)
187. S. Achilefu, H. N. Jimenez, R. B. Dorshow, J. E. Bugaj, E. G. Webb, R. R. Wilhelm, R. Rajagopalan, J. Johler, J. L. Erion: Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents. J.
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Med. Chem. 45, 2003-2015 (2002)
2001
188. R. B. Dorshow, S. Achilefu, J. E. Bugaj, R. Rajagopalan: Receptor-targeted fluorescent contrast agents for in vivo imaging. Optics & Photonics News 12, 28, (2001)
189. S. Achilefu, J. E. Bugaj, R. B. Dorshow, H. N. Jimenez, R. Rajagopalan: New approach to optical imaging of tumors. Proc. SPIE-Int. Soc. Opt. Eng. 4259, 110-114, (2001)
190. R. Rajagopalan, S. Achilefu, H. N. Jimenez, E. G. Webb, M. A. Schmidt, J. E. Bugaj, and R. B. Dorshow: Targeted Type 1 phototherapeutic agents using azido-peptide bioconjugates. Proc. SPIE-Int. Soc. Opt. Eng. 4259, 129-132, (2001)
191. S. Achilefu, J. E. Bugaj, R. B. Dorshow, H. N. Jimenez, R. Rajagopalan, R. R. Wilhelm, E. G. Webb, J. L. Erion: Site-specific targeted fluorescent contrast agents. Proc. SPIE-Int. Soc. Opt. Eng. 4156, 69-78 (2001)
192. J. E. Bugaj, S. Achilefu, R. B. Dorshow, R. Rajagopalan: Novel Fluorescent Contrast Agents for Optical Imaging of In Vivo Tumors Based on a Receptor-Targeted Dye- Peptide Conjugate Platform. J. Biomed. Optics 6, 122-133 (2001)
2000
193. S. Achilefu, R. B. Dorshow, R. Rajagopalan, and J. E. Bugaj: Novel Receptor-Targeted Fluorescent Contrast Agents for In Vivo Tumor Imaging. Invest. Radiol. 35, 479-485 (2000)
194. S. Achilefu, R. R. Wilhelm, H. N. Jimenez, and A. Srinivasan: A New Method for the Synthesis of Tri-t-butyl Diethylenetriaminepentaacetic Acid and Its Derivatives. J. Org. Chem. 65, 1562-1565 (2000)
195. R. Rajagopalan, P. Uetrecht, J. E. Bugaj, S. Achilefu, and R. B. Dorshow: Stabilization of the Optical Tracer Agent Indocyanine Green Using Noncovalent Interactions. Photochem. & Photobiol. 71, 347-350 (2000)
196. R. B. Dorshow, S. Achilefu, J. E. Bugaj, and R. Rajagopalan: In Vivo Optical Imaging using Tumor Specific Exogenous Fluorescent Contrast Agents. Bull. Am. Phys. Soc. 45, 956 (2000)
197. S. Achilefu, R. B. Dorshow, J. E. Bugaj, and R. Rajagopalan: Tumor Specific Fluorescent Contrast Agents. Proc. SPIE-Int. Soc. Opt. Eng. 3917, 80-86 (2000)
198. R. Rajagopalan, J. E. Bugaj, R. B. Dorshow, C. J. Venkatriamani, P. A. Uetricht, and S. Achilefu: Polyionic Fluorescent bioconjugates as Tracer Agents for Continuous Monitoring of Renal Function. Proc. SPIE-Int. Soc. Opt. Eng. 3924, 28-34 (2000)
1990-1999
199. J. E. Bugaj, J. L. Erion, M. A. Schmidt, R. R. Wilhelm, S. I. Achilefu, and A. Srinivasan: Biodistribution and Radiotherapy Studies Using Samarium-153 and Lutetium-177 DTPA Conjugates of Y3- Octreotate. J. Nuclear Med. 40, 223P, #996 (1999)
200. C. Gerardin-Charbonnier, S. Auberger, L. Molina, S. Achilefu, M-A. Manresa, P. Vinardell,
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M-R. Infante, and C. Selve: Preparation and Antibiotic Activity of Monobactam Analogues of Nocardicins. Prep. Biochem. Biotechnol. 29, 257- 72 (1999)
201. R. B. Dorshow, J. E. Bugaj, S. I. Achilefu, R. Rajagopalan, and A. H. Combs: Monitoring physiological function by detection of exogenous fluorescent contrast agents. Bull. Am. Phy. Soc. 44, 334 (1999)
202. R. B. Dorshow, J. E. Bugaj, S. Achilefu, R. Rajagopalan, and A. H. Combs: Monitoring physiological function by detection of exogenous fluorescent contrast agents. Proc. SPIE-Int. Soc. Opt. Eng. 3599, 2-8 (1999)
203. L. Molina, A. Perani, M. Infante, M. Manresa, M. Maugras, S. Achilefu, M. Stebe, and C. Selve: Bioactive surfactants containing a -lactam group: synthesis and properties. J. Chem. Soc. Chem. Commun. 12, 1279-1280 (1995)
204. S. Achilefu, L. Mansuy, C. Selve, and S. Thiebaut: Synthesis of 2H, 2H-perfluoroalkyl and 2H-perfluoroalkenyl carboxylic acids and amides. J. Fluorine Chem. 70, 19-26 (1995)
205. S. Achilefu, C. Selve, M. Stebe, J. Ravey, and J. Delpuech: Monodisperse perfluoroalkyl oxyethylene nonionic surfactants with methoxy capping: synthesis and phase behavior of water/surfactant binary systems. Langmuir 10, 2131-2138 (1994)
206. H. Wassermann, E. Azim, G. Coudert, S. Achilefu, and C. Selve: Symmetric di-or tetra-alkyl substituted monodisperse polyoxyethylene glycols: synthesis and surface properties. J. Chem. Soc. Perkin Trans. 2, 2043-2047 (1992)
207. C. Selve and S. Achilefu: Synthesis and stability studies of a family of fluorinated nonionic surfactants. Informations Chimie 326, 156-158 (1991)
208. C. Selve, C. Delestre, S. Achilefu, M. Maugras, and F. Attioui: Synthesis and evaluation of the properties of fluorinated amphiphilic amides of 2,2-bis(hydroxymethyl) propionic acid. J. Chem. Soc.,Chem. Commun. 13, 863-864 (1991)
209. C. Selve and S. Achilefu: Synthesis of monodisperse perfluoroalkyl-oxyethylene surfactants with methoxy capping: surfactants of high chemical inertness. J. Chem. Soc., Chem. Commun. 13, 911-912 (1990)
210. C. Selve, S. Achilefu, and L. Mansuy: A new procedure for the synthesis of ether-bridged nonionic surfactants. Synth. Commun. 20, 799-807 (1990)
Book, Book Chapter and Booklets
2011 W. Akers, S. Achilefu: Molecular Reporter Systems for Optical Imaging, Chapter 42 of Handbook of Biomedical Optics, 2011, CRC Press
2011 Yang Liu, S. Achilefu: Targeted Molecular Imaging with Cytate: From Bench toward Bedside, Chapter 6 of Targeted Molecular Imaging, 2011, CRC Press
2002 S. Achilefu: Molecular Beacons in Optical Imaging [Short Course Booklet]. The International Society for Optical Engineering, San Jose, CA (SPIE, Bellingham, WA, January 2002)
2001 S. Achilefu: Introduction to the chemistry and biochemistry of photodiagnostic and phototherapeutic agents [Short Course Booklet]. The International Society for Optical Engineering, San Jose, CA (SPIE, Bellingham, WA, January 2001)
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Scientific Magazines and Newsletters
4/2012 Featured in The Scientist: Eyes on Cancer
10/2011 Featured in National Cancer Institute Bulletin: Profiles in Research
6/2011 Featured in National Cancer Institute Bulletin: Spotlight - Imaging Boot Camp for Cancer Researchers
1/2011 Authored news article: MOLECULAR IMAGING/FLUORESCENCE/CANCER PATHOLOGY: Unraveling the basis of disease with NIR molecular probes; published in BioOptcis World
6/2006 Summary of research included in the 2006 NIBIB Strategic Plan
2005 Career and research activities published in Journal for Minority Medical Student; published in NIBIB Profiles (BB12).
2/2004 Expert opinion on multimodal imaging of diseases featured in Biophotonics International
12/2000 Research on optical contrast agents featured in Biomedical Optics Newsletter
12/2000 Expert opinion on optical contrast agents featured in Optical Engineering Reports
09/1993 Blood substitute research featured in the editorial column of Chemistry in Britain
10/1993 Innovative work on artificial blood substitute featured in a British Broadcasting Corporation Television program, Tomorrow’s World, London, UK
08/1992 Blood substitute work featured in Oxford Innovation News (1992)