curriculum vitae october 10, 2014 a. personal information...

CURRICULUM VITAE October 10, 2014 A. Personal Information:

Name in Full: Leo Mascarenhas, M.D., M.S. Business Address: Division of Hematology-Oncology Children’s Hospital Los Angeles 4650, Sunset Boulevard, MS #54 Los Angeles, California 90027 Telephone: (323) 361-2529 Facsimile: (323) 361-8174 E-mail: [email protected] Home Address: 3705, La Crescenta Avenue Glendale, California 91208-1022 Telephone: (818) 249-0467 Date of Birth: July 17, 1967 Birthplace: Bangalore, India Citizenship: United States of America Marital status: Married B. Education: Pre-University 1982 -1984 St. Joseph’s College of

Arts and Science Bangalore, India Medical School 1984 -1989 St. John’s Medical College Bangalore, India Graduate School: Master of Science Clinical and Biomedical Investigations Keck School of Medicine University of Southern California August 2006- January 2008 Internship General Rotating Internship St. John’s Medical College Hospital Bangalore, India 1989 – 1990 Residency Resident, Department of Pediatrics New York Medical College

Valhalla, New York. 1992 – 1995

Leo Mascarenhas, M.D., M.S. Curriculum Vitae, October 10, 2014.

Fellowship Fellow, Division of Hematology-Oncology Children’s Hospital Los Angeles University of Southern California Los Angeles, California. 1995 – 1998

Fellow, Division of Research Immunology/Bone Marrow Transplantation Children’s Hospital Los Angeles University of Southern California Los Angeles, California 1998-1999

Licensure California: A 054324 Certification American Board of Pediatric Hematology- Oncology–

Board Certified- 1998. Re-certified- 2005

American Board of Pediatrics- Board Certified – 1995

Re-certified – 2002 Maintenance of Certification- 2012 FLEX, June 1993 FMGEMS, July 1991

Basic Life Support- Re-certified, September 2011 Human Research Certification, Committee on Clinical Investigation, Children’s Hospital Los Angeles Certified- September, 2000 to present Good Clinical Practice Committee on Clinical Investigation, Children’s Hospital Los Angeles Certified- September, 2000 to present

C. Professional Background:

Academic Appointments Associate Professor of Clinical Pediatrics Keck School of Medicine University of Southern California August 2007- present

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Assistant Professor of Clinical Pediatrics Keck School of Medicine University of Southern California April 2001-July 2007 Instructor of Pediatrics Keck School of Med.icine University of Southern California November 1999-March 2001 Tutor, Department of Physiology St. John’s Medical College Bangalore, India May1992-June 1992

Clinical Appointments Attending Physician Division of Hematology and Oncology Department of Pediatrics Children’s Hospital Los Angeles 1998- Present

General Physician Emmaus Swiss Referral Hospital Palamaner, India 1990-1992

General Physician St. Ignatius Hospital Honavar, India 1992

Administrative Appointments Section Head, Oncology Children’s Center for Cancer and Blood Diseases

Children’s Hospital Los Angeles November 2013-present

Division Head, Oncology

Children’s Center for Cancer and Blood Diseases Children’s Hospital Los Angeles November 2011-October 2013 Director, Solid Tumor Program Children’s Center for Cancer and Blood Diseases Children’s Hospital Los Angeles November 2011-present Director, Bone and Soft Tissue Tumor Program Children’s Center for Cancer and Blood Diseases Children’s Hospital Los Angeles July 2011-present

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Director Clinical Trials Office-Hematology/Oncology Children’s Hospital Los Angeles February 2008- present Associate Director of the Bone and Soft Tissue Tumor Program: Children’s Center for Cancer and Blood Diseases Children’s Hospital Los Angeles July 1998-June 2011 Honors and Awards Top Doctors Pasadena ® 2014

Best Doctors in America ® 2014-2015

Southern California Super Doctors ® 2014




Top Doctors Pasadena ® 2013 Best Doctors in America ® 2011-2012


Top Doctors Pasadena ® 2012

America’s Top Pediatricians ® 2011 Top Doctors Pasadena ® 2011 Southern California Super Doctors ® 2011 Morris and Mary Press Humanism Award Nominee-

2010 Elected to Society of Pediatric Research 2010 Best Doctors in America ® 2010-2011



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Walter Laug Distinguished Teaching Award For Inspirational Teaching and Guidance Children’s Hospital Los Angeles Pediatric Hematology

Oncology Fellowship 2009


Morris and Mary Press Humanism Award Nominee- 2006

Philip E. Rothman Memorial Award For Outstanding Teaching, Guidance and Inspiration Children’s Hospital Los Angeles General Pediatric Residency 2006 Morris and Mary Press Humanism Award Nominee-2005 8th Junior Faculty Mentored Career Development Award

July 2005 Morris and Mary Press Humanism Award Nominee-2004 Morris and Mary Press Humanism Award Nominee-2002 Morris and Mary Press Humanism Award Nominee-2001 American Society of Hematology-Travel Merit Award 1999 American Association for Cancer Research Scholarship Award for Clinical Oncologists in Molecular Biology 1997

Bristol Myers Squibb Award for Superior Academic

Achievement, New York Medical College 1995 First Rank in Obstetrics and Gynecology, St. John’s

Medical College, 1989 Certificates of Honor in Anatomy (1986) and Pathology

(1987), St. John’s Medical College

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Certificates of Merit in Pharmacology and Microbiology, (1987), St. John’s Medical College.

Most Talented Student Award (1988), St. John’s

Medical College Specific Teaching Responsibilities General Pediatric Residents- July 1998-June 2011

Lectures on Leukemia, Lymphoma, Fever and Neutropenia, Blood Products, Tumorlysis Syndrome, General Pediatric Residents- July 1998-present Lectures on Abdominal masses, Bone and Soft Tissue Tumors, Autologous Hematopoietic Stem Cell Transplant, Supportive care and Veno-Occlusive Disease of the Liver Pediatric Hematology/ Oncology Fellows- July 1998- present Lectures on Oncologic Emergencies, Chemotherapy, Supportive care, Procedures in Hematology and Oncology, Bone and Soft Tissue Sarcomas, Clinical research and ethics Course Director-Biology Course for Hematology/Oncology Fellows- July 2003- June 2007 Weekly 1-hour conference on molecular biology, cancer cytogenetics, basic immunology, pharmacology and biostatistics. Responsible for conception, introduction, organization, syllabus and evaluation of program. Hematology- Oncology Fellowship Orientation July 1998- present Summer Oncology Fellowship program for medical students- July 2001-present 2 hour lecture on Bone and Soft Tissue Tumors.

Committee Memberships: Vice Chair, Voting Body Children’s Oncology Group (COG) September 2014- present

Trustee at Large, Board of Directors American Society of Pediatric Hematology and Oncology (ASPHO) April 2014- present Member, Steering Committee Translational and Clinical Sciences Program Norris Comprehensive Cancer Center

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July 2014-present Physician Champion Febrile Neutropenia Care Variation Task Force February 2014- present Member, Search Committee

Head of BMT- Clinical Affairs /Clinical Research Children’s Hospital Los Angeles January 2014 Member, Search Committee

Head of BMT and Cell Therapy- Basic/Translational Research Children’s Hospital Los Angeles January 2014 Member, Search Committee Director- Leukemia/Lymphoma Program Children’s Hospital Los Angeles January 2014 Member, Search Committee Pediatric Radiation Oncology USC/Children’s Hospital Los Angeles January 2014

Member, Campaign Committee

American Society of Pediatric Hematology and Oncology April 2013- present Elected member, Voting Body Steering Committee Children’s Oncology Group April 2013- present Member, Ad Hoc Advisory Committee- IRB/Huron Life Sciences-CHLA October 2012-present Chair, Search Committee Director of Clinical Research Children’s Hospital Los Angeles 2012 Chair, Search Committee Clinical Investigator, Solid Tumor Program Division of Hematology Oncology Children’s Hospital Los Angeles 2012

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Member, Search Committee Physician Scientist, Leukemia-Lymphoma Program Division of Hematology Oncology Children’s Hospital Los Angeles 2012

Member, Clinical and Translation Science- Clinical Trials Unit (CTSI-CTU) Advisory and Steering Committee (USC-CHLA)

July 2011-present CHLA Bio repository Advisory and Governance Committee September 2011-present Focus under Forty eLearning Committee American Society of Clinical Oncology December 2011- present Development Committee American Society of Pediatric Hematology/Oncology June 2011-present Oncology Drug Advisory Committee Food and Drug Administration- Pediatric Consultant October 2009- present

Certification and Education Committee American Society of Pediatric Hematology/Oncology April 2009-present Scholarship Oversight Committee Hematology Oncology Fellowship Program Children’s Hospital Los Angeles July 2007-present

Program Committee American Society of Pediatric Hematology/Oncology April 2007-April 2013 Bone Sarcoma Liaison To the Adult Oncology Co-operative Groups Adolescent and Young Adult Committee Children’s Oncology Group January 2007- December 2008 Soft Tissue Sarcoma Committee Children’s Oncology Group November 2005- present Medical Staff Executive Committee

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Children’s Hospital Los Angeles July 2010- June 2012 Medical Staff Executive Committee Children’s Hospital Los Angeles July 2005- June 2009

Pediatric Resident Education Committee Children’s Hospital Los Angeles July 2004- present Committee on Clinical Investigation (IRB) Children’s Hospital Los Angeles January 2003-July 2011 Bone Sarcoma Steering Committee Children’s Oncology Group April 2002-present Hematology/Oncology Fellowship Committee Children’s Hospital Los Angeles July 2001-present Bone Sarcoma Committee Children’s Oncology Group May 2001- present Young Investigators Committee

Children’s Oncology Group May 2000- March 2004.

Minority Affairs Committee Children’s Oncology Group March 2004 to December 2008 Chemotherapy Task Force

Children’s Hospital Los Angeles July 1999-present

Quality Assurance and Quality Improvement Committee

Division of Hematology/Oncology Children’s Hospital Los Angeles

June 1997-present. D. Society Memberships: Society of Pediatric Research 2010-present

Connective Tissue Oncology Society 2010- Present American Society of Clinical Oncology

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2002-present American Society of Hematology 2001-present American Society of Pediatric Hematology/Oncology 1999-present American Society of Gene Therapy 1998-2001

American Association for Cancer Research 1996 – 2000 American Academy of Pediatrics 1992 – 2007, 2011-present

American Medical Association 1992-1995

E. Consultantship: Scientific Rationale, Clinical Trial Design, Treatment

Plan and Biology Studies of the First South American Ewing Sarcoma Family of Tumors Multinational Study

November 2008- present

Scientific Rationale, Clinical Trial Design, Treatment Plan and Biology Studies of the Second Brazilian Osteosarcoma Treatment Group Protocols for Localized and Metastatic Osteosarcoma. January 2007- present

F. Research Activities: Major Area of research Interest:

Clinical research and Developmental Therapeutics for Bone and Soft Tissue Sarcomas Principal Investigator (Mascarenhas) Hyundai Scholar Grant 2014 A Pilot Clinical Trial of replacing vincristine with vinorelbine in newly diagnosed adolescent and young adult patients with rhabdomyosarcoma January 2015-December 2016 $250,000.00 Principal Investigator (Mascarenhas) A Pilot Clinical Trial of replacing vincristine with vinorelbine in newly diagnosed adolescent and young adult patients with rhabdomyosarcoma Shred Kids Cancer (2014-2015) $ 50,000.00

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Principal Investigator (Mascarenhas) Cancer Control Initiative City of Hope National Medical Center June 2013- June 2016 $ 76, 383.00 per year Principal Investigator (Mascarenhas) CureSearch Clinical Trials Advancement Award 2013 $ 40,000.00 Site Investigator- Amgen Pharmaceuticals AMG954: A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of Panitumumab in Children with Solid Tumors January 2014-present Principal Investigator (Mascarenhas) Solid Tumor Clinical Trials Shred Kids Cancer (2013-2014) $ 51,000.00 Site Investigator-Eleison Pharmaceuticals

EP-ILC-201- Phase 2 Study of Inhaled Lipid Cisplatin in Pulmonary Recurrent Osteosarcoma June 2013- present Site Investigator- Pfizer A Phase I/II Study of Sunitinb in young patients with Advanced Gastrointestinal Stromal Tumor May 2013-present

Site Investigator-Bristol Meyer Squib CA 184-178- A Phase 2 Study of Ipilimumab in Children and Adolescents (12 to < 18 years) with previously treated or untreated, unresectable Stage III or Stage IV Malignant Melanoma May 2013- present Site Investigator-Roche N025390-An open-label, multicenter, single-arm, Phase I dose-escalation with efficacy tail extension study of RO5185426 in pediatric patients with surgically incurable and unresectable Stage IIIC or Stage IV melanoma harboring BRAF V600 mutations March 2012- present Principal Investigator (Mascarenhas)

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Max of a Million Dreams Foundation for Cancer Research Novel therapeutics for childhood sarcoma (2012-2013) $20.000.00

Principal Investigator (Mascarenhas) Names Family Foundation Clinical Research Infrastructure Award Bone and Soft Tissue Tumors (2012-2014) $ 100,000.00 Principal Investigator (Mascarenhas) COG ADVL1014 Shred Kids Cancer (2012-2013) $ 7000.00 Principal Investigator (Mascarenhas) Jean Perkins Foundation Sarcoma Research Program (2012-2014) $ 600,000.00 Principal Investigator (Mascarenhas) Names Family Foundation Childhood Liver Cancer (2012) $ 10,000.00

Principal Investigator (Mascarenhas) Pediatric Cancer Research Foundation (PCRF) Clinical Trials Infrastructure Award November 2010-June 2014 $575,000.00 Site Principal Investigator (Mascarenhas) Sarcoma Alliance for Research through Collaboration (SARC) Children’s Hospital Los Angeles 2010-present SARC012- A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Cross-Over, Phase II.5 Study of Saracatinib (AZD0530), a Selective Src Kinase Inhibitor, In Patients with Recurrent Osteosarcoma Localized to the Lung 5U10 CA098543 (Reaman) Children’s Oncology Group Site Principal Investigator (Mascarenhas)

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Salary Support Children’s Hospital Los Angeles February 2008-2011 $ 225,228.00 5U10 CA098543 (Adamson) Children’s Oncology Group Site Principal Investigator (Mascarenhas) Salary Support Children’s Hospital Los Angeles February 2011-2013 $ 168,600.00 5U10 CA098543 (Reaman) NIH/NCI Site Principal Investigator (Mascarenhas) Children's Oncology Group (COG) Multi-Institution Clinical Trials Group- February 2008- 2011 Per Patient Reimbursement: $ 657,339. 80. 5U10 CA098543 (Adamson) NIH/NCI Site Principal Investigator (Mascarenhas) Children's Oncology Group (COG) Multi-Institution Clinical Trials Group- February 2011- 2013 Per Patient Reimbursement: $ 692,479.00 Principal Investigator (Mascarenhas) Children's Oncology Group (COG) Multi-Institution Clinical Trials (2009-present) St. Baldrick’s Foundation Supplement: $ 362,300.00 CureSearch Supplement: $ 57,780.00 Childhood Human Tissue Network $ 1280.00

3U10CA98543-07S1 (Reaman) Children’s Oncology Group (June 1, 2009- May 31, 2011) Investigator (Mascarenhas)

Children’s Hospital Los Angeles Accelerating Clinical Trials in Novel Oncology Pathways (ACTNOW) ARRA Program

COG ANBL0931 $45,999.00

Principal Investigator- CCI 06-00092

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Phase I trial of Oxaliplatin and Doxorubicin in children and Adolescents with relapsed and refractory extra-cranial solid tumors of non-hematopoietic origin- 8th Junior Faculty Mentored Career Development Award- $100,000 over 2 years 2005-2007 (35% effort) $ 10,000 -Max of a Million Dreams Foundation (1 year -2008) P30CA014089 (Jones) NIH/NCI (2006-2009) Comprehensive Cancer Center Clinical Trials Core Specific Funding $71,148.74 Co- Principal Investigator (Faculty Mentor to Dr. Rajkumar Venkatramani) - CCI-09-00214 Phase I trial of Vincristine, escalating doses of Irinotecan, Temozolomide and Bevacizumab in pediatric and adolescent patients with relapsed/refractory solid tumors of non-hematopoietic origin. $ 10,000- Max of a Million Dreams Foundation (1 year 2010) P30CA014089 (Jones) NIH/NCI (2010-2012) Comprehensive Cancer Center Clinical Trials Core Specific Funding $ 68,001.44

2U10 CA098543 (Reaman) - COG Chair’s Grant NIH/NCI $42,336.00 (2008-2010) Study Chair (Mascarenhas): COG AEWS07P1 Interval Compression of chemotherapy using Vincristine, Topotecan and Cyclophosphamide together with standard chemotherapy in patients with localized Ewing Sarcoma- A COG Pilot Study (closed to enrollment)

5U10 CA098543 (Reaman/Adamson)-COG Chair’s Grant NIH/NCI $ 37,376.00 (2010-present) Study Chair (Mascarenhas): COG ARST0921 A Randomized Phase II Trial of Bevacizumab or Temsirolimus in combination with Intravenous Vinorelbine and Cyclophosphamide in Patients with Recurrent/refractory Rhabdomyosarcoma

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Co-Chair (Mascarenhas): COG AEWS1031 A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma

Vice Chair (Mascarenhas) - COG ARST0531 Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) Alternating with Vincristine and Irinotecan for Patients with Intermediate-Risk Rhabdomyosarcoma

Co-Investigator (Mascarenhas) - COG AEWS0521- Study Committee A randomized Phase II trial of Bevacizumab combined with Vincristine. Topotecan and Cyclophosphamide in patients with first recurrence Ewings Sarcoma (completed).

Co-Investigator (Mascarenhas) - COG ADVL0211- Study Committee

Phase I trial of Bcl-2 antisense combined with cytotoxic chemotherapy in relapsed childhood solid tumors (completed)

Sarcoma Clinical Trials T.J. Martell Fund-Pediatric Cancer Research Program January 1, 2007- December 31, 2007 $ 4733.45

Local Principal Investigator For Bone and Soft Tissue Tumor Protocols Children’s Hospital Los Angeles

Clinical Investigator Bone and Soft Tissue Tumor Program Leukemia and Lymphoma Program Children’s Hospital Los Angeles Principal investigator, Acute Lymphoblastic Leukemia Biology Studies for Gene Transfer into Leukemia Cells of high-risk and relapse, 1998-2002.

G. Mentorship: Josephine HaDuong, M.D.

Hematology-Oncology faculty May 2013-present

Chintan Parekh, M.D. Hematology-Oncology faculty August 2012-present

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Andreza Senerchia M.D. International Pediatric Oncology Fellow January 2012- September 2012 Shevta Gupta, M.D. General Pediatric Resident July 2010- present Batul Suterwala M.D. Hematology- Oncology Fellow July 2009-present

Rajkumar Venkatramini, M.D. Hematology-Oncology Fellow July 2009- August 2011 Hematology- Oncology Faculty September 2011- August 2014 Dennis A. Dias, M.D. General Pediatrics Resident July 2008-June 2010 Tanja Gruber M.D., Ph.D. Hematology-Oncology Fellow July 2006- June 2009 Saro Armenian, D.O.

Hematology-Oncology Fellow July 2005- June 2008 Edward Garmey, M.D. Hematology Oncology Fellow July 2004-June 2005 Theresa Harned, M.D. Hematology-Oncology Fellow July 2003- January 2007 Hematology-Oncology Faculty July 2009-present Tanja Gruber M.D., Ph.D. General Pediatrics Resident July 2003- June 2006 Saro Armenian, D.O. General Pediatrics Resident July 2002-June 2005 Geetha Puthenveetil, M.D. Hematology-Oncology Fellow July 2000- June 2004

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BIBLIOGRAPHY (*Trainees)

Peer Review:

1. Leo Mascarenhas, Renata Stripecke, Scott S. Case, Dakun Xu, Kenneth I Weinberg, Donald B. Kohn: Gene delivery to B precursor acute lymphoblastic leukemia cells. Blood 92(10): 3537-3545, Nov. 1998.

2. Renata Stripecke, Angelo A. Cardoso, Karen A. Pepper, Dianne C. Skelton, Xiao-Jin Xu,

Leo Mascarenhas, Kenneth I Weinberg, Lee M. Nadler, Donald B. Kohn: Lentiviral vectors for efficient delivery and expression of CD80 and GM-CSF in human ALL and AML cells. Blood 96(4): 1317-1326, August 2000.

3. Shi-Qi Wu, Kwan Tien Loh, Xiao-Rong Chen, Wan Jong Joo, Leo Mascarenhas:

Transient myeloproliferative disorder in a phenotypically normal infant with i(21)q mosaicism. Cancer Genetics and Cytogenetics 136 (2002) 138-140.

4. E. Y Huang, L. Mascarenhas, G.H. Mahour: Wilms Tumor and horseshoe kidney; Case

report and review of the literature. J Pediatr Surg. 2004 Feb;39(2):207-12

5. Emily G. Farrow, Siobhan I. Davis, Sean D. Mooney, Peter Beighton, Leo Mascarenhas, Yvonne R. Gutierrez, Pisit Pitukcheewanont, Kenneth E. White -Extended Mutational Analyses of FGFR1 in Osteoglophonic Dysplasia. American Journal of Medical Genetics 2006, March 1; 140(5): 537-9

6. *Saro H. Armenian, William V. La Via, Stuart E. Siegel, Leo Mascarenhas: Evaluation

of Persistent Pulmonary Infiltrates in Pediatric Oncology Patients. Pediatr Blood Cancer 2007, Feb; 48(2) 165-72

7. *Janet M. Yoon, R. Cartland Burns, Marcio H. Malogolowkin, Leo Mascarenhas:

Treatment of Infantile Choriocarcinoma of the Liver. Pediatr Blood Cancer. 2007 Jul; 49(1) 99-102.

8. *Theresa M. Harned, Leo Mascarenhas: Severe methotrexate toxicity precipitated by

intravenous radiographic contrast. J Pediatr Hematol Oncol 2007 Jul; 29(7) 496-499.

9. *Catherine Madigan, *Saro H. Armenian, Marcio H. Maologolowkin, Leo Mascarenhas: Extracranial malignant rhabdoid tumors in children- The Children’s Hospital Los Angeles Experience Cancer. 2007 Nov 1;110(9):2061-6.

10. *Saro H. Armenian, Jill A. Hoffman, Anna M. Butturini, Neena Kapoor, Leo

Mascarenhas: Invasive diagnostic procedures for pulmonary infiltrates in pediatric hematopoietic stem cell transplant recipients. Pediatr Transplant 2007 Nov; 11(7): 736-42

11. Patrick J. Leavey, Leo Mascarenhas, Neyssa Marina, Mark Krailo, James Miser, Mark

Bernstein, Linda Granowetter and Holcombe Grier. Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence Pediatr Blood Cancer. 2008 Sep; 51(3):334-8.

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12. Hamayun Imran, Felicity Enders, Mark Krailo, Franklin Sim, Scott Okuno, Douglas Hawkins, Joseph Neglia, R. Lor Randall, Richard Womer, Leo Mascarenhas, Carola A. S. Arndt. “Does time to resumption of chemotherapy after definitive surgery affect prognosis in non-metastatic osteosarcoma?" J Bone Joint Surg Am. 2009 Mar 1;91(3):604-12

13. Rovelo MO, Kim R, Mascarenhas L, Hammoudeh J, Urata MM, Recurrent and Refractory Giant Cell Tumor of the Jaw. J Craniofac Surg. 2009 Nov; 20(6): 2245-8.

14. Leo Mascarenhas, Elizabeth. R. Lyden, Philip. P. Breitfeld, Sarah. S. Donaldson, Charles. N. Paidas, David. M. Parham, James A. Anderson, William. H. Meyer, Douglas. S. Hawkins: Randomized phase II window study of two schedules of irinotecan (CPT-11) and vincristine (VCR) in rhabdomyosarcoma (RMS) at first relapse/disease progression. J Clin Oncol. 2010 Oct 20;28(30):4658-63

15. *Venkatramani R, Ma NS, Pitukcheewanont P, Malogolowkin MH, Mascarenhas L. Gorham’s disease and diffuse lymphangiomatosis in children and adolescents. Pediatr Blood Cancer. 2011 Apr;56(4):667-670.

16. Hingorani P, Seidel K, Krailo M, Mascarenhas L, Meyers P, Marina N, et al. Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: A report from the Children’s Oncology Group. Pediatr Blood Cancer. 2011 Dec 1;57(6):939-942.

17. Arkader A, Myung K, Stanley P, Mascarenhas L: Ewing Sarcoma of the Tibia Mimicking Fibrous Dysplasia. J Pediatr Orthop B. 2011 Nov 16. [Epub ahead of print]

18. Bhatia S, Landier W, Shangguan M, Hageman L, Schaible AN, Carter AR, Hanby CL,

Leisenring W, Yasui Y, Kornegay NM, Mascarenhas L, Ritchey AK, Casillas JN, Dickens DS, Meza J, Carroll WL, Relling MV, Wong FL: Nonadherence to Oral Mercaptopurine and the Risk of Relapse in Hispanic and Non-hispanic White Children with Acute Lymphoblastic Leukemia: A Report from the Children’s Oncology Group. J Clin Oncol. 2012 Jun 10;30(17):2094-101. Epub 2012 May 7

19. *Venkatramani R, Malogolowkin MH, Wang L, Mascarenhas L: Pleuropulmonary Blastoma: A Single Institution Experience. J Pediatr Hematol Oncol. 2012 Jul;34(5):e182-5.

20. *Venkatramani R, Wang L, Malvar J, Dias D, Sposto R, Malogolowkin MH, Mascarenhas L: Tumor Necrosis Predicts Survival following Neo-Adjuvant Chemotherapy for Hepatoblastoma. Pediatr Blood Cancer. 2012 Sep;59(3):493-8. doi: 10.1002/pbc.24038. Epub 2011 Dec 20.

21. *Venkatramani R, Olch A, Mascarenhas L, Yoon S, Suterwala B, Wong K. Correlation of long term pulmonary injury with radiation dose distribution in childhood cancer survivors. Pract Radiat Oncol. 2012 Jul-Sep;2(3):237-40. doi:10.1016/j.prro.2011.07.003. Epub 2011 Aug 26

22. Kotecha R, Mascarenhas L, Jackson HA, Venkatramani R. Radiological Features of Gorham’s Disease. Kotecha R, Mascarenhas L, Jackson HA, Venkatramani R. Clin Radiol. 2012 Aug;67(8):782-8. Epub 2012 Mar 15

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23. Ibrahim DA, Mascarenhas L, Tovar JP, Arkader, A: Orthopedic Case of the Month_ A

14 year old boy with medial thigh soft tissue mass. Clin Orthop Relat Res. 2012 Nov 6. [Epub ahead of print]

24. Mascarenhas L, Malogolowkin M, Armenian SH, Sposto R, Venkatramani R: A phase I study of oxaliplatin and doxorubicin in pediatric patients with relapsed or refractory extracranial non-hematopoietic solid tumors. Pediatr Blood Cancer. 2013 Jul;60(7):1103-7

25. *Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L: Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):942-8

26. *Venkatramani R, Malogolowkin M, Davidson TB, May W, Sposto R, Mascarenhas L: A phase I study of vincristine, irinotecan, temozolomide and bevacizumab (vitb) in pediatric patients with relapsed solid tumors. PLoS One. 2013 Jul 22;8(7):e68416.

27. *Mehta B, Mascarenhas L, Zhou S, Wang L, Venkatramani R: Inflammatory myofibroblastic tumors in childhood. Pediatr Hematol Oncol. 2013 Oct;30(7):640-5.

28. Venkatramani R, Malogolowkin MH, Mascarenhas L: Treatment of multiply relapsed wilms tumor with vincristine, irinotecan, temozolomide and bevacizumab. Pediatr Blood Cancer. 2013 Sep 21. doi: 10.1002/pbc.24785. [Epub ahead of print]

29. Venkatramani R, Mascarenhas L. Successful treatment of recurrent nasopharyngeal carcinoma with doxorubicin and oxaliplatin without irradiation. J Pediatr Hematol Oncol. 2013 Oct 31. [Epub ahead of print]

30. Shah R, Tran HC, Randolph L, Mascarenhas L, Venkatramani R. Hepatoblastoma in a fifteen month old infant with trisomy 13. Am J Med Genet A. 2013 Dec 5 [Epub ahead of print]

31. Puliyel MM, Mascarenhas L, Zhou S, Sapra A, Dal Cin P, French CA, Venkatramani R. Nuclear protein in testis midline carcinoma misdiagnosed as adamantinoma . J Clin Oncol. 2014 Jan 27. [Epub ahead of print]

32. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. Pulmonary outcomes in patients with Hodgkin’s lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014 Jan 31. doi: 10.1002/pbc.24969. [Epub ahead of print]

33. Chan R, Mascarenhas L, Venkatramani R: Hepatoblastoma and hypoplastic kidneys: A new association. Pediatr Blood Cancer. 2014 Jan 13. doi: 10.1002/pbc.24936. [Epub ahead of print]

34. De A, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Mascarenhas L, Keens TG, Venkatramani R. Correlation of pulmonary function abnormalities with dose volume histograms in children treated with lung irradiation. Pediatr Pulmonol. 2014 Mar 18. doi: 10.1002/ppul.23034. [Epub ahead of print]

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http://www.ncbi.nlm.nih.gov/pubmed/23335436



http://www.ncbi.nlm.nih.gov/pubmed?term=Venkatramani%20R%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Kamath%20S%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Wong%20K%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Olch%20AJ%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Malvar%20J%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Sposto%20R%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Goodarzian%20F%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Freyer%20DR%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Keens%20TG%5BAuthor%5D&cauthor=true&cauthor_uid=23726005

http://www.ncbi.nlm.nih.gov/pubmed?term=Mascarenhas%20L%5BAuthor%5D&cauthor=true&cauthor_uid=23726005


35. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera

C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S. Carnitine and cardiac dysfunction in childhood cancer survivors treated with anthracyclines. Cancer Epidemiol Biomarkers Prev. 2014 Apr 9. [Epub ahead of print]

36. Rajkumar Venkatramani, Poone Shoureshi, Leo Mascarenhas: High dose alkylator therapy for extracranial malignant rhabdoid tumor in children. Pediatr Blood Cancer. 2014 Apr 30. doi: 10.1002/pbc.25093. [Epub ahead of print]

37. De A, Guryev I, LaRiviere A, Kato R, Wee CP, Mascarenhas L, Keens TG, Venkatramani R. Pulmonary Function Abnormalities in Childhood Cancer Survivors Treated with Bleomycin. Pediatr Blood Cancer. 2014 May 2. doi: 10.1002/pbc.25098. [Epub ahead of print]

38. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S. Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors Clin Cancer Res. 2014 Jun 19. pii: clincanres.3490.2014. [Epub ahead of print]

39. Su A, Low L, Li X, Zhou S, Mascarenhas L, Barnhill RL. De Novo Congenital Melanoma: Analysis of Two Cases with Array Comparative Genomic Hybridization. Am J Dermatopathol. 2014 Jul 21. [Epub ahead of print]

Articles in press:

1. Venkatramani R, Malogolowkin M, Stein J, Genyk Y, Mascarenhas L. Effect of neoadjuvant chemotherapy on resectability of stage III and stage IV hepatoblastoma. (British Journal of Surgery, September 2014)

2. Josephine H. HaDuong, Andrew A. Martin, Stephen X. Skapek, Leo Mascarenhas. Sarcomas (Pediatric Clinics of North America, September 2014)

3. Hung C. Tran, Araz Marachelian A, Rajkumar Venkatramani, Rima F. Jubran, Leo Mascarenhas. Oxaliplatin and Doxorubicin for relapsed or refractory high-risk neuroblastoma. (Pediatric Hematology Oncology, October 2014)

Articles Submitted:

1. Leo Mascarenhas, Judy. L. Felgenhauer, Doojduen Villaluna, J. Dominic Femino, Nadia. N. Laack, Sarangarajan. Ranganathan, James Meyer, M.D, Richard B. Womer, Richard Gorlick, Mark D. Krailo, Neyssa Marina: Pilot study of adding vincristine, topotecan, and cyclophosphamide to interval compressed chemotherapy in newly diagnosed patients with localized Ewing sarcoma: A report from the Children's Oncology Group (Annals of Oncology, August 2014).

2. Smita Bhatia, Wendy Landier, Lindsey Hageman, Heeyoung Kim, Cara Hanby, Nancy

Kornegay, Bruce Bostrom, Jacqueline Casillas, David S Dickens, Kelly W Maloney, Leo Mascarenhas, Jane Meza, A. Kim Ritchey, Amanda M Termuhlan, William L Carroll,

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F Lennie Wong, Mary V Relling: Non-adherence to oral 6-mercaptopurine in a multi-ethnic cohort of children with acute lymphoblastic leukemia: A report from the Children’s Oncology Group (Blood, July 2014)

3. Randall Chan, Leo Mascarenhas, Rajkumar Venkatramini. Hepatoblastoma in a Patient with Methylmalonic Aciduria (American Journal of Medical Genetics, August 2014)

4. *Venkatramani R, Triche TJ, Wang L, Wai D, Shimada H, Schaub B, Mascarenhas L. Insulin like growth factor 2 expression differentiates pleuropulmonary blastoma from embryonal rhabdomyosarcoma (Pediatric Blood and Cancer, October 2014)

Non Peer Reviewed: 1. Leo Mascarenhas, Mason C. Bond, Nita L. Siebel: Expanded access through CTSU to sarcoma trial COG AEWS1031 for adolescents and young adults. Journal of Adolescent and Young Adult Oncology Journal of Adolescent and Young Adult Oncology. March 2011, 1(1): 61-63 2. Leo Mascarenhas. Novel Combination Chemotherapy for Localized Ewing Sarcoma

-Phase III Randomized Study of Adding Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide to Standard Chemotherapy in Patients with Non-Metastatic Extracranial Ewing Sarcoma (COG-AEWS1031). National Cancer Institute Bulletin March 22, 2011, Volume 8, No. 6

Articles in preparation:

1. Leo Mascarenhas, Philip.P. Breitfeld, Elizabeth. R. Lyden, Charles. N. Paidas, Sara. S.

Donaldson, David. M. Parham, James A. Anderson, Douglas. S. Hawkins, William. H. Meyer: Protocol Driven Salvage Therapy for Relapsed Rhabdomyosarcoma and Safety and Efficacy of Tirapazamine (TPZ) combined with Cyclophosphamide (C) and Doxorubicin (D) in Rhabdomyosarcoma (RMS) at first relapse/disease progression.

2. Gupta S*, Venkatramani R, Zhou S, Wang L, Mascarenhas L. Transitional liver cell

tumor of childhood.

3. Leo Mascarenhas, Mark Krailo, Richard Wormer, Linda Granowetter, Holcombe Grier: Paraspinal Ewing Sarcoma/PNET-Clinical features and Outcome on Children’s Oncology Group trials

4. Leo Mascarenhas, Mark Krailo, Richard Wormer, Linda Granowetter, Holcombe

Grier: Craniofacial Ewing Sarcoma/PNET-Clinical features and Outcome on Children’s Oncology Group trials

5. Andreza Senerchia, Rajkumar Venkatramani, Amita Sapra, Leo Mascarenhas. Tumor

markers and radiographic imaging in the follow up of extra-cranial germ cell-tumors and liver tumors of childhood and adolescence.

6. Rachana Shah, Rajkumar Venkatramani, Richard Sposto, Leo Mascarenhas. Local

control for primary and metastatic sites in newly diagnosed stage IV rhabdomyosarcoma

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7. May C. Chien, Leo Mascarenhas, Rajkumar Venkatramini. Zoledronic acid for the treatment of pediatric central giant cell granuloma

8. Leo Mascarenhas, William H. Meyer, Elizabeth Lyden, David A. Rodeberg, Daniel Joseph Indelicato, Corrine M Linardic, James Robert Anderson, Douglas S. Hawkins. Randomized phase II trial of bevacizumab and temsirolimus in combination with vinorelbine (V) and cyclophosphamide (C) for first relapse/disease progression of rhabdomyosarcoma (RMS): A report from the Children’s Oncology Group (COG)

ABSTRACTS:

1 L. Mascarenhas, R. Stripecke, K.A. Pepper, L.W. Barsky, D.B. Kohn: Gene delivery to human pre-B acute lymphoblastic leukemia cell lines. #4619, Blood 90(10): 415b, 1997

2 Renata Stripecke, Dianne C. Skelton, Tanja A. Gruber, Leo Mascarenhas, Paul

Pattengale, Donald B. Kohn: Enhancement of anti-leukemia immune response through co-expression of CD80 and other immunomodulators. #137 American Society for Gene Therapy, First Annual Meeting, 1998.

3 Leo Mascarenhas, Renata Stripecke, Dakun Xu, Scott S. Case, Donald B. Kohn: Gene

delivery to human pre-B acute lymphoblastic leukemia cells. #569 American Society for Gene Therapy, First Annual Meeting, 1998.

4 L. Mascarenhas, A. Butturini, A. Epstein-Edereich, R. Seeger, J. Villablanca and S.

Siegel: High-dose chemotherapy and hematopoietic stem cell transplant for advanced pediatric tumors. Joint Annual Meeting of the International Society of Paediatric Oncology and the American Society for Pediatric Hematology/Oncology, 1999.

5 Renata Stripecke, Nori Kasahara, Karen A. Pepper, Dianne C. Skelton, Xia-Jin Xu, Leo

Mascarenhas, Kenneth I Weinberg, Donald B. Kohn: Development of Lentiviral Vectors for Immuno-gene Therapy of Acute Leukemias. Blood 94 (10) 182a #791, 1999.

6 J. Franklin, J Church, N. Kapoor, J. Ortega, P. Rios, L. Mascarenhas, T. Hofstra, K.

Weinberg, J. Chu, C. Anderson, J. Rowland: Childhood Non-Hodgkin’s Lymphoma (NHL) in acquired and congenital immunodeficiency patients. Blood 94 (10) 435a #1993, 1999.

7 Leo Mascarenhas, Elzbieta Smogorzewska, Felix Burutto, Dapeng Yao, Robertson

Parkman, Gay M. Crooks, Kenneth I. Weinberg: Expression of common γ chain (γc, CD132) and interleukin-7 receptor α (IL-7Rα, CD127) on B-precursor acute lymphoblastic leukemia (ALL): Potential application for depletion of leukemic cells from normal HSC. Blood 94 (10) 142a #620, 1999.

8 A. Butturini, L. Mascarenhas, M. Malogolowkin, J. Ortega, F. Ozkaynak, P. Reynolds,

B. Edelman, M. Bottcher, R. Seeger, S. Siegel: Autotransplant vs chemotherapy in pediatric metastatic sarcomas. Blood 96(11) 423a, #1819, 2000.

9 J. M. Van Tornout, A. Butturini, L. Mascarenhas, M. Malogolowkin, S.E. Siegel: Does

race affect outcome in pediatric metastatic sarcoma? Proc ASCO Vol 21, 277b: 2927, 2002.

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10 S. Rheingold, M. Krailo, S. Blaney, M. Hogarty, L. Mascarenhas, K. Adlard, M.

Barnich, J. Murphy, R. Chandula, P. Adamson: A phase I trial of G3139 (Bcl-2 Antisense) combined with cytoxic chemotherapy in relapsed pediatric solid tumors-A Children’s Oncology Group Study, Proc ASCO Vol 23, No 16S, 217s,: 3102, 2005.

11 Emily G. Farrow, Tobias M. Larson, Shiobhan I. Davis, Xijie Yu, Michael J. Econs, Erik

Imel, Alex Lichtler, Pisit Pitukcheewanont, Leo Mascarenhas, Yvonne Gutierrez, Keith Condon, David B. Burr, James K. Hartfield, Peter Beighton, Kenneth E. White: Osteoglophonic Dysplasia Defines Roles for FGFR1 in Bone Formation and Mass- Presented at, American Society for Bone and Mineral Research-ASBMR-2005

12 *Saro Armenian, William La Via, Stuart Siegel, Leo Mascarenhas: Evaluation of

Persistent Pulmonary Infitrates in Pediatric Oncology Patients -Presented at the 37th Congress of the International Society of Pediatric Oncology (SIOP), 2005.

13 *Catherine Madigan, Marcio Malogolowkin, Leo Mascarenhas: Extra-Cranial

Rhabdoid Tumors in Childhood: A Single Instituition Experience -Presented at 37th Congress of The International Society of Pediatric Oncology ( SIOP) 2005..

14 Patrick J. Leavey, Leo Mascarenhas, Neyssa Marina, Mark Krailo, James Miser, Mark

Bernstein, Linda Granowetter and Holcombe Grier. Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence ASCO 2007

15 Nina Ma, Leo Mascarenhas, Pisit Pitukcheewanont: Bisphosphonate and interferon

alpha 2b therapy in two children with Gorham-Stout disease- Pediatric Academic Societies 2008

16 L. Mascarenhas, E. R. Lyden, P. P. Breitfeld, S. S. Donaldson, C. N. Paidas, D. M.

Parham, W. H. Meyer, D. S. Hawkins: Randomized phase II window study of two schedules of irinotecan (CPT-11) and vincristine (VCR) in rhabdomyosarcoma (RMS) at first relapse/disease progression – America Society of Clinical Oncology-2008

17 P. P. Breitfeld, L. Mascarenhas, E. R. Lyden, C. N. Paidas, S. S. Donaldson, D. M.

Parham, D. S. Hawkins, W. H. Meyer: Safety and Efficacy of Tirapazamine (TPZ) combined with Cyclophosphamide (C) and Doxorubicin (D) in Rhabdomyosarcoma (RMS) at first relapse/disease progression. America Society of Clinical Oncology-2008

18 Douglas S. Hawkins, Kristy Seidel, Mark Krailo, Leo Mascarenhas, Paul Meyers,

Neyssa Marina, Ernest U. Conrad.. Body Mass Index (BMI) at Diagnosis is associated with Surgical Wound Complications in Patients with Localized Osteosarcoma: A Report from the Children’s Oncology Group -Connective Tisssue Oncology Society 2008

19 L. Mascarenhas, S. Armenian, J. L. Harrington, H. Mahmoud, R. Sposto, M. H. Malogolowkin. Phase 1 trial of oxaliplatin and doxorubicin in children and adolescents with recurrent solid tumors. American Society of Clinical Oncology 2010

20 P. Leavey, J. L. Glade Bender, L. Mascarenhas, L. Granowetter, M. Anderson, M. D.

Krailo, R. G. Gorlick, N. Marina. Feasibility of bevacizumab (NSC 704865, BB-IND# 7921) combined with vincristine, topotecan, and cyclophosphamide in patients with first

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recurrent Ewing sarcoma (EWS): A Children’s Oncology Group (COG) study. American Society of Clinical Oncology 2010

21 *R. Venkatramani, M.H. Malogolowkin, L.Mascarenhas. Pleuropulmonary Blastoma- Children’s Hospital Los Angeles Experience: International Society of Pediatric Oncology 2010

22 *Venkatramani R, Wang L, Malvar J, Sposto R, Malogolowkin M, Mascarenhas L. Tumor necrosis predicts survival following neo-adjuvant chemotherapy for hepatoblastoma- 24th annual meeting of the American Society of Pediatric Hematology/Oncology. Pediatr Blood Cancer. 2011; 56: 897–973.

23 *Rajkumar Venkatramani, Sunil Kamath, Kenneth Wong, Arthur Olch, Fariba Goodarzian, David Freyer, Thomas G. Keens, Leo Mascarenhas. Pulmonary outcomes following treatment for childhood cancer with lung irradiation. International Society of Paediatric Oncology SIOP XXXXIII Congress, Auckland, New Zealand, October 26-30, 2011.

24 *Venkatramani R, Kamath S, Wong K, Olch A, Malvar J, Goodarzian F, Freyer D, Keens T, Mascarenhas L. Pulmonary outcomes following treatment of childhood Hodgkin lymphoma with contemporary irradiation. 25th annual meeting of the American Society of Pediatric Hematology/Oncology. Pediatr Blood Cancer. 2011; 58: 1014–1097.

25 *Gupta S, *Venkatramani R, Zhou S, Wang L, Mascarenhas L. Transitional liver tumor of childhood. 25th annual meeting of the American Society of Pediatric Hematology/Oncology. Pediatr Blood Cancer. 2011; 58: 1014–1097.

26 *Mehta B, Zhou S, Wang L, Mascarenhas L, Venkatramani R. Inflammatory myofibroblastic tumors: Children’s Hospital Los Angeles experience. 25th annual meeting of the American Society of Pediatric Hematology/Oncology. Pediatr Blood Cancer. 2011; 58: 1014–1097.

27 Kamath S, Venkatramani R, Wong K, Olch A, Goodarzian F, Freyer D, Mascarenhas L, Keens TG. Pulmonary Function Abnormalities In Children Treated With Partial Lung Irradiation And Their Correlation With Dose Volume Histogram. 2012 American Thoracic Society International conference, 2012. Am J Respir Crit Care Med. 185: A6141.

28 Kamath S, Venkatramani R, Wong K, Olch A, Goodarzian F, Freyer D, Mascarenhas L, Keens TG. Cardiopulmonary Exercise Evaluation Of Children Treated With Lung Irradiation. 2012 American Thoracic Society International conference, 2012. Am J Respir Crit Care Med. 185: A6142.

29 Venkatramani R, Triche T, Wang L, Wai D, Shimada H, Schaub B, Mascarenhas L. Effect of insulin-like growth factor 2 gene expression on pleuropulmonary blastoma and embryonal rhabdomyosarcoma. American Society of Clinical Oncology Annual Meeting 2012. J Clin Oncol 30, 2012 (suppl; abstr 9564).

30 Venkatramani R, Kamath S, Wong K, Olch A, Malvar J, Sposto R, Goodarzian F, Freyer D, Keens T, Mascarenhas L. Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children receiving lung irradiation. 12th International Conference

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on Long-Term Complications of Treatment of Children and Adolescents for Cancer, 2012, Williamsburg, United States.

31 De A, La Riviera, Guryev I, Kato R, Keens TG, Mascarenhas L,Venkatramani R. Pulmonary Function Abnormalities In Childhood Cancer Survivors Treated With Bleomycin. American Thoracic Society International Conference 2013.

32 Venkatramani R, Malogolowkin M, Mascarenhas L. Treatment of multiply relapsed

Wilms tumor with vincristine, irinotecan, temozolomide and bevacizumab. 8th

International Pediatric Renal Tumor Conference 2013.

33 Saro Armenian, Sarah Gelehrter, Tabitha Vase, Rajkumar Venkatramani, Wendy Landier, Karla Wilson, Claudia Herrera, Leah Reichman, John David Menteer, Leo Mascarenhas, David Robert Freyer, Kalyanasundaram Venkataraman, Smita Bhatia: Comprehensive profiling of cardiac dysfunction in asymptomatic childhood cancer survivors (CCS) treated with anthracyclines. J Clin Oncol 31, 2013 (suppl; abstr 10020)

34 Kristin Baird, Denise K. Reinke, Joseph Gerald Pressey, Leo Mascarenhas, Noah Federman, Neyssa Marina, Sant P. Chawla, Joanne Pigues Lagmay, John M. Goldberg, Mohammed M. Milhem, David Mark Loeb, James E. Butrynski, Katherine A. Janeway, Brian Turpin, Arthur P. Staddon, Sheri L. Spunt, Eve T. Rodler, Scott Schuetze, Scott H. Okuno, Lee J. Helman: A randomized, double-blinded, placebo-controlled, multi-institutional, cross-over, phase II.5 study of saracatinib (AZD0530), a selective src kinase inhibitor, in patients with recurrent osteosarcoma localized to the lung J Clin Oncol 31, 2013 (suppl; abstr TPS10591)

35 Rajkumar Venkatramani, Marcio Malogolowkin, Tom Davidson, William May, Richard Sposto, Leo Mascarenhas. A phase I study of vincristine, irinotecan, temozolomide and bevacizumab (vitb) in pediatric patients with relaspsed solid tumors (ASPHO, April 2013)

36 Andreza Senerchia, Rajkumar Venkatramani, Amita Sapra, Leo Mascarenhas. The role of tumor markers and radiographic imaging in the follow up of extracranial germ cell tumors of childhood and adolescence (ASPHO, April 2013)

37 Hung Tran, Araz Marachelian, Rajkumar Venkatramani, Rima Jubran, Leo Mascarenhas. Oxaliplatin and doxorubicin treatment for high risk relapsed and refractory neuroblastoma (ASPHO, April 2013)

38 Mammen Puliyel, Leo Mascarenhas, Shengmei Zhou, Amita Sapra, Christopher French, Paola Dal Cin, Rajkumar Venkatramani. NUT midline carcinoma misdiagnosed as adamantinoma (ASPHO, April 2013)

39 Rachana Shah, Hung Tran, Linda Randolph, Leo Mascarenhas, Rajkumar Venkatramani. Hepatoblastoma in a fifteen month old infant with trisomy 13 (ASPHO, April 2013)

40 Rachana Shah, Rajkumar Venkatramani, Richard Sposto, Leo Mascarenhas. Local control for primary and metastatic sites in newly diagnosed stage IV rhabdomyosarcoma (CTOS, October 2013)

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41 Leo Mascarenhas, William H. Meyer, Elizabeth Lyden, David A. Rodeberg, Daniel

Joseph Indelicato, Corrine M Linardic, James Robert Anderson, Douglas S. Hawkins. Randomized phase II trial of bevacizumab and temsirolimus in combination with vinorelbine (V) and cyclophosphamide (C) for first relapse/disease progression of rhabdomyosarcoma (RMS): A report from the Children’s Oncology Group (COG) (ASCO 2014)

42 Douglas S. Hawkins, James Robert Anderson, Leo Mascarenhas, Geoffrey Brian McCowage, David A. Rodeberg, Suzanne L. Wolden, David Parham, Lynn Million, Sarah S. Donaldson, Andrea Anita Hayes-Jordan, Kenneth L.B. Brown, Lisa A. Teot, Sheri L. Spunt, William H. Meyer;Vincristine, dactinomycin, cyclophosphamide (VAC) vs VAC/v+irinotecan (VI) for intermediate risk rhabdomyosarcoma (IRRMS): A report from the Children’s oncology group soft tissue sarcoma committee. (ASCO 2014)

43 Wendy Landier, Yanjun Chen, Lindsey Hageman, Heeyoung Kim, Bruce C. Bostrom,

Jacqueline N. Casillas, David S. Dickens, William E. Evans, Kelly W. Maloney, Leo Mascarenhas, Arthur Kim Ritchey, Amanda M. Termuhlen, William L. Carroll, Mary V. Relling, Florence Lennie Wong, Smita Bhatia; Factors associated with non-adherence to oral 6-mercaptopurine (6MP) in children with acute lymphoblastic leukemia (ALL): A report from Children’s oncology group (COG) study AALL03N1 (ASCO 2014)

44 May C. Chien, Leo Mascarenhas, Rajkumar Venkatramini. Zoledronic acid for the treatment of pediatric central giant cell granuloma (SIOP 2014)

45 Lindsey Hageman, Wendy Landier, Yanjun Chen, Heeyoung Kim, Nancy Kornegay, William E Evans, Bruce Bostrom, Jacqueline Casillas, David S. Dickens, Anne Angiolillo, Glen Lew, Kelly W Maloney, Leo Mascarenhas, Lu Chen, A. Kim Ritchey, Amanda M Termuhlan, William L Carroll, Mary V Relling, F Lennie Wong, Smita Bhatia Impact of 6 Mercaptopurine (6MP) Pill-Taking Habits on Adherence, Thioguanine Nucleotide (TGN) Levels and Relapse Risk in Children with Acute Lymphoblastic Leukemia (ALL): Results from a Children’s Oncology Group (COG) Study (AALL03N1) (ASH 2014)

CHAPTERS: 1. Leo Mascarenhas and M. Fevzi Ozkayanak: Internet Chapter: Moderately emetogenic

chemotherapy-management of chemotherapy induced nausea and vomiting- yourdoctor.com 2. Leo Mascarenhas, Stuart Siegel, Logan Spector, Carola Arndt, Dominic Femino and Marcio

Malogolowkin.: Malignant Bone Tumors in Adolescents and Young Adults- A Children’s Oncology Group and SEER monograph Bleyer A, O’Leary M, Barr R, Ries LAG (eds): Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, including SEER Incidence and Survival: 1975-2000. National Cancer Institute, NIH Pub. No. 06-5767. Bethesda, MD 2006.

3. Leo Mascarenhas and Geoffrey McCowage: Rare tumors in Childhood and Adolescence:

Cancer in Children and Adolescents. William L Carroll and Jonathan L. Finlay, Jones and Bartlett Publishers 2010

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INVITED LECTURES:

1. Angiogenesis and Cancer: Brazilian Osteosarcoma Treatment Group Consensus Meeting, Instituto de Oncologia Pediatrica, Sao Paolo, Brazil, January 23, 2006

2. Relapsed Osteosarcoma: Brazilian Osteosarcoma Treatment Group Consensus Meeting, Instituto de Oncologia Pediatrica, Sao Paolo, Brazil, January 24, 2006

3. Childhood Rhabomyosarcoma: Pediatric Hematology/Oncology Grand Rounds, Children’s Hospital of Michigan, November 17, 2006

4. Rhabdomyosarcoma-Update for the Pediatrician: Pediatric Grand Rounds, Women’s and Children’s Hospital, Los Angeles County, June 19, 2007

5. Bone and Soft Tissue Tumors in Childhood and Adolesence: Pediatric Grand Rounds, Kaiser Permanente Metropolitan Medical Center, July 18, 2007

6. Rhabdomyosarcoma-What have we learned from clinical trials.Pediatric Grand Rounds, Loma Linda University, California, July 20, 2007

7. Clinical trials in Childhood Sarcomas: Pediatric Hematology/Oncology Grand Rounds, Children’s Hospital of Michigan, August 17, 2007

8. Childhood Acute Lymphoblastic Leukemia: Medical School Grand Rounds, St. John’s National Academy of Heath Science, Bangalore, India November 6, 2007

9. Childhood Acute Lymphoblastic Leukemia: Medical School Grand Rounds, Fr. Mueller’s Medical College, Mangalore, India, November 7, 2007

10. Childhood Acute Lymphoblastic Leukemia: Medical School Grand Rounds, Kasturba Medical College, Mangalore, India. November 7, 2007

11. Childhood Rhabdomyosarcoma. Pediatric Grand Rounds, Kasturba Medical College, Mangalore, India. November 8, 2007.

12. Childhood Rhabdomyosaroma- Southern California Association of Pediatric Hematology Oncology Nursing. May 30, 2008

13. Osteosarcoma- State of the Art- X1 Brazilian Society of Pediatric Oncology, November 9, 2008.

14. Clinical Trials in Childhood Rhabdomyosarcoma- Pediatric Grand Rounds, Miller Children’s Hospital, Long Beach, California- January 31, 2009

15. Outcomes of Children with Sarcomas- Symposium: Soft Tissue Sarcomas- What Basic Science has to offer- American Society of Pediatric Hematology Oncology (ASPHO) 2010 Annual Meeting, Montreal, Canada

16. Staging and Grouping of Childhood Rhabdomyosarcoma- Workshop- Risk Assignment for Treatment of Childhood Rhabdomyosarcoma- American Society of Pediatric Hematology Oncology (ASPHO) 2010 Annual Meeting, Montreal, Canada

17. Introduction to Liver Tumors and Transitional Liver Tumors of Childhood and Adolescence- What the Dicken’s-It’s A Liver Twist- Childhood Liver Tumor Symposium, American Society of Pediatric Hematology Oncology (ASPHO) 2011 Annual Meeting, Baltimore, MD

18. Faculty Discussant- Sarcoma Poster Discussion Session, American Society of Clinical Oncology (ASCO) 2011 Annual Meeting, Chicago, IL

19. Faculty Discussant- Pediatric Oncology Oral Abstract Session, American Society of Clinical Oncology (ASCO) 2012 Annual Meeting, Chicago, IL

20. Visiting Professor-Children’s Hospital of Westmead, Sydney, Australia- Clinical Trials in Childhood Rhabdomyosarcoma (August 1, 2012)

21. Cancer Chemotherapy and Pharmacology -Faculty, American Society of Pediatric Hematology Oncology ( ASPHO) Review Course, Dallas, TX (February 2013)

22. Visiting Professor-Children’s Mercy Hospital, Kansas City, MO. Childhood Rhabdomyosarcoma (June 24-25, 2013)

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23. Visiting Professor- St. John’s Medical College, Bangalore, India (August 3-5, 2013) 24. Where there is a Wilms’ there is a way- the past, present and future of clinical trials for

Wilms Tumor- St. John’s Medical College Golden Jubilee Pediatric Symposium, August 3, 2013

25. Childhood Rhabdomyosarcoma- State of the Art- St. Martha’s Hospital, Bangalore India (August 6, 2013)

26. Where next with clinical trials in childhood Rhabdomyosarcoma, The Stuart E. Siegel Symposium, Los Angeles, CA (October 4, 2013)

27. Visiting Professor- Children’s Hospital of Wisconsin and Medical College of Wisconsin (October 21-23, 2013)

28. Pediatric type sarcomas in the Adolescent and Young Adult. Adolescent and Young Adult Oncology Symposium, Milwaukee, WI (October 23, 2013)

29. Sarcomas in the Adolescent and Young Adult: Hematology-Oncology Grand Rounds, Children’s Hospital Los Angeles ( March 2014)

30. Interval Compression for Ewing Sarcoma, Faculty Instructor, Maintenance of Certification Program, American Board of Pediatrics, ASPHO Annual Meeting, Chicago. (May 2014)

31. Visiting Professor- Federal University of Sao Paolo, Sao Paolo, Brazil (August 20-23, 2014)

32. Osteosarcoma- What Clinical Trials have Taught Us, VIII Brazilian Bone Tumor Meeting, Sao Paolo (August 2014)

33. Treatment of Ewing Sarcoma- Evidence Based Strategies, VIII Brazilian Bone Tumor Meeting, Sao Paolo (August 2014)

34. Rhabdomyosarcoma- The IRSG and COG Experience, VIII Brazilian Bone Tumor Meeting, Sao Paolo (August 2014)

35. Pediatric type sarcomas in the Adolescent and Young Adult Population, VIII Brazilian Bone Tumor Meeting, Sao Paolo (August 2014)

36. Introduction to Pediatric Soft Tissue Sarcomas, Childhood Soft Tissue Sarcoma Symposium, Los Angeles (November 2014)

37. The past, present and future of Childhood Rhabdomyosarcoma, Pediatric Grand Rounds and 10th Anniversary Celebrations, Maria Fareri Children’s Hospital, Vahalla, New York (December 2014)

MISCELLANEOUS: Faculty of 1000- Contributing Faculty Member in Pediatric Oncology Ad Hoc Journal Reviewer 1. Cancer 2. Pediatric Blood and Cancer 3. Journal of Pediatric Hematology and Oncology 4. Journal of Clinical Oncology 5. Journal of Adolescent and Young Adult Oncology 6. American Journal of Clinical Oncology Symposiums/Workshops 1. Where the is a Wilms, there is a way- Symposium on Wilms Tumor, American Society of

Pediatric Hematology Oncology (ASPHO) 2008 Annual Meeting, Cincinnati, Ohio.

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2. We all must grow up and stay healthy- Symposium on Adolescent and Young Adults and Transition of Care, American Society of Pediatric Hematology Oncology (ASPHO) 2008 Annual Meeting, Cincinnati, Ohio.

3. Soft Tissue Sarcomas, What basic science has to offer- Symposium, American Society of Pediatric Hematology Oncology (ASPHO) 2010 Annual Meeting, Montreal, Canada

4. Risk Assignment for Childhood Rhabdomyosarcoma- Workshop, American Society of Pediatric Hematology Oncology (ASPHO) 2010 Annual Meeting, Montreal, Canada

5. Wilms Tumor Symposium, November 2010 (Pablove Foundation), Los Angeles, CA 6. What the Dicken’s-It’s A Liver Twist- Childhood Liver Tumor Symposium, American

Society of Pediatric Hematology Oncology (ASPHO) 2011 Annual Meeting, Baltimore, MD

7. Bone Marrow-Derived Stem Cells and the Tumor Microenvironment- Translational Medicine Symposium, American Society of Pediatric Hematology Oncology (ASPHO) 2011 Annual Meeting, Baltimore, MD

8. Childhood Cancer Survivorship Symposium, November 2011 (Pablove Foundation) Los Angeles, CA

9. Rare Tumor Symposium-American Society of Pediatric Hematology Oncology (ASPHO) 2012 Annual Meeting, New Orleans, LA

10. Melanoma- A Primer for the Pediatric Oncologist-American Society of Pediatric Hematology Oncology (ASPHO) 2012 Annual Meeting, New Orleans, LA

11. Childhood Brain Tumor Symposium, November 2012 (Pablove Foundation), Los Angeles, CA

12. Oncology Novel Therapeutics Symposium- American Society of Pediatric Hematology Oncology (ASPHO) 2013 Annual Meeting, Miami, FL.

13. Photons and Protons- Rays of Hope And Less To Despair? Radiation Oncology Symposium, American Society of Pediatric Hematology Oncology (ASPHO) 2013 Annual Meeting, Miami, FL.

14. Oncology Band-Aids: Management Of Acute Chemotherapy Toxicity Workshop, American Society of Pediatric Hematology Oncology (ASPHO) 2013 Annual Meeting, Miami, FL.

15. Childhood Acute Lymphoblastic Leukemia Symposium, November 2013 (Pablove Foundation) Los Angeles, CA.

16. International Paratesticular Rhabdomyosarcoma Workshop, November 2014, Los Angeles, CA

17. International Childhood Soft Tissue Sarcoma Think Tank, November 2014, Los Angeles, CA

18. Childhood Soft Tissue Sarcoma Sympsoium, November 2014 (Pablove Foundation) Los Angeles, CA

Community Service 1. Member, Board of Directors, The Pablove Foundation, July 2009-present 2. Chair, Scientific Advisory Board, The Pablove Foundation, July 2010-present 3. President, Mangalore Abroad Association, February 2012-February 2014.

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curriculum vitae october 10, 2014 a. personal information...

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