CURRICULUM VITAE NAME: David Michael DeMarini LOCATION: Integrated Systems Toxicology Division (B105-03), U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA TEL 1-919-541-1510, FAX 1-919-541-0694, E-mail: demarini.david@epa.gov CITIZENSHIP: United States of America EDUCATION: Illinois State University, Normal, IL, B.S., Biological Sciences, 1972 M.S., Biological Sciences, 1974 Ph.D., Biological Sciences, 1980 RESEARCH EXPERIENCE 1974 - 1975 Assistant Research Microbiologist, U.S. Department of Agriculture, Northern Regional Research Center, Peoria, IL 1975 - 1979 Research Assistantship, Illinois State University, Normal, IL 1980 - 1982 Postdoctoral Investigator, Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN 1983 - 1984 Research Geneticist, Oak Ridge Associated Universities, Cellular and Genetic Toxicology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 1985 - Present Genetic Toxicologist, Genetic and Cellular Toxicology Branch, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle, North Carolina 27711, USA TEACHING EXPERIENCE 1972 - 1974 Teaching Assistantship, Illinois State University, Normal, IL 1991 - 2000 Adjunct Associate Professor, UNC 2001 - Present Adjunct Professor, Department of Environmental Science and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC

GRADUATE STUDENTS TRAINED 1. Jessie G. Levine, Ph.D., Department of Environmental Science and Engineering, University of North Carolina at Chapel Hill, May, 1992. "Factors Influencing Mutation Spectra at the hisD3052 Allele of Salmonella typhimurium" 2. Carolyn F. Felton, M.S., Department of Biology, North Carolina Central University, Durham, May, 1993. "Mutation Spectra of an Organic Extract of a Chlorinated Drinking Water Sample in Salmonella typhimurium" 3. Maria S. Taylor, M.S.P.H., Department of Environmental Science and Engineering, University of North Carolina at Chapel Hill, July, 1993. "Evaluation of the Additivity Assumption Using the Spiral Salmonella Mutagenicity Assay with Binary Combinations of Single Chemicals and Complex Mixtures" 4. George M. Woodall Jr., Ph.D., Department of Toxicology, North Carolina State University, Raleigh, May, 1996. "Effects of Dietary Casein Levels on the Activation and Metabolism of Promutagens by Rat Hepatic S9, Microsomes, and Cytosol" 5. Daniel T. Shaughnessy, M.S.P.H., Department of Environmental Science and Engineering, University of North Carolina at Chapel Hill, December, 1999. “Mutation Spectra of the Drinking Water Mutagen 3-Chloro-4-Methyl-5-Hydroxy-2(5H)-Furanone (MCF) in Salmonella TA100 and TA104: Comparison to MX” 6. Bijit Kundu, M.S., Department of Environmental Science and Engineering, University of North Carolina at Chapel Hill, August, 2001. “Mutagenicity in Salmonella of Nitrohalomethanes, a Recently Recognized Class of Disinfection By-Products: Comparison to Halomethanes” 7. Courtney Granville, M.S.P.H., Department of Environmental Science and Engineering, University of North Carolina at Chapel Hill, April, 2002, “Genotoxicity of Source Water Contaminants 1,3-Dichloropropane, 2,2-Dichloropropane, and 1,1-Dichloropropene in Salmonella, the E. coli, Prophage-Induction Assay, and Human Lymphoblastoid Cells” 8. Daniel T. Shaughnessy, Ph.D., Department of Environmental Science and Engineering, University of North Carolina at Chapel Hill, September, 2002, “Effects of the Antimutagens Vanillin and Cinnamaldehyde on Spontaneous Mutation in E. coli lacI strains and Salmonella TA104 and on Global Gene Expression in Human HepG2 Cells” 9. Mina Kato, Ph.D., Department of Epidemiology, University of North Carolina at Chapel Hill, anticipated for May, 2003, “Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil” 10. Raju Y. Prasad, Ph.D., Department of Environmental Science and Engineering, University of North Carolina at Chapel Hill, June, 2013, “Genotoxicity of Titanium Dioxide Nanoparticles”

POSTDOCTORAL INVESTIGATORS TRAINED 1. Dr. Douglas A. Bell (USA, 1988-1990), currently Head of the Environmental Genomics Group, Laboratory of Molecular Genetics, NIEHS, RTP, NC 2. Dr. Amal Abu-Shakra (Lebanon, 1990-1993), Professor, Biology Department, North Carolina Central University, Durham, NC 3. Dr. Takeshi Ohe (Japan, 1998-1999), currently Professor, Kyoto Women’s University, Kyoto, Japan 4. Dr. Defa Tian (China, 1998-2001), currently on staff at Georgetown University, Washington, DC 5. Dr. Stefano Landi (Italy, 1998-2000), currently Assistant Professor, Biology Dept., University of Pisa, Italy 6. Dr. Kunihiro Funasaka (Japan, 2002-2003), currently Chief Engineer, Osaka City Institute of Public Health, Osaka, Japan) 7. Dr. William O. Ward (USA, 2005-2007), currently Staff Scientist, NHEERL, US EPA, RTP, NC 8. Dr. Carol D. Swartz (USA, 2005-2007), currently a Staff Scientist, Integrated Laboratory Systems, Durham, NC 9. Dr. Jin-Sung Ra (Korea, 2007-2008), currently a research associate, Switzerland 10. Dr. Esra Mutlu (Turkey, 2011-2013), currently research associate at UNC, Chapel Hill, NC 11. Dr. Jose Zavala (USA, 2014-present) HONORS 1. Outstanding Ph.D. Student of the Year, Phi Sigma Society, 1979 2. Outstanding Young Alumni Award, Illinois State University, 1990 2. Honorable Mention, Scientific and Technological Achievement Award (STAA), US EPA, 1994, for "Mutagenicity and Chemical Analysis of Emissions from the Open Burning of Scrap Rubber Tires" 3. Level II Award, Scientific and Technological Achievement Award (STAA), US EPA, 1997, for "Elucidating Molecular Features of the Salmonella Assay and Mutation Spectra of Complex Environmental Mixtures" 4. Alumni Achievement Award, Illinois State University, 2000. 5. Environmental Mutagen Society Education and Student Member Committee Award, 2002. 6. Level III Award, Scientific and Technological Achievement Award (STAA), US EPA, 2003, for “Demonstrating that Mutations in Tumors Reflect Exposure to Environmental Mutagens and Carcinogens”

4 7. Level I Award (highest award), Scientific and Technological Achievement Award (STAA), US EPA, 2004, for “Identifying the Ultimate Genotoxic Forms of Arsenic and the Class of Mutations They Induce.” 8. Level III Award, Scientific and Technological Achievement Award (STAA), US EPA, 2005, for Setting Standards for Conducting Multidisciplinary Environmental Effects Studies of Complex Particulate Mixtures” 9. Alumni Hall of Fame Award, Illinois State University, 2006 10. US EPA, NHEERL Goal 3 Award for “Leadership in the Environmental Research Community” 2006 11. Level II Scientific and Technological Achievement Award (STAA), US EPA, 2008, for “Review of Genotoxicity and Carcinogenicity of Drinking Water Disinfection By-products” 12. Level II Scientific and Technological Achievement Award (STAA), US EPA, 2008, for “Review of Health Effects of Swimming Pool Water” 13. U.S. EPA, Office of Research and Development (ORD) 2008 “Science Communications Award” 14. The 2011 Alexander Hollaender Award from the Environmental Mutagen Society 15. A 2011 Level III Scientific and Technological Achievement Award (STAA), US EPA for “A Review of the Salmonella Mutagenicity Assay and How it Informs the Development of 21st Century Toxicology Assays” 16. A 2011 Honorable Mention Scientific and Technological Achievement Award (STAA) for “The First Comprehensive Characterization of DBPs in Indoor Swimming Pool Water and Their Role in the Water's Mutagenicity” EDITORSHIPS AND EDITORIAL BOARDS EDITOR Mutation Research—Reviews (Editor 1998-present) EMS Newsletter (Co-Editor 1988-1991) Environmental and Molecular Mutagenesis (Book Review Editor 1989-1993) EDITORIAL BOARDS Mutation Research (1985-1997)

Environmental and Molecular Mutagenesis (1984-1989; 1993-present) Mutagenesis (1992-1995; 2006-2013) Environmental Health Perspectives (1988-1993)

5 Teratogenesis Carcinogenesis and Mutagenesis (1990-1992) EMS Newsletter (1986-1988) Pan-African Environmental Mutagen Society Newsletter (1994-present) Environmental Mutagens and Carcinogens (2001-2005) Genes and Environment (2006-present) Frontiers in Cancer Epidemiology and Prevention (2011-present) PROFESSIONAL APPOINTMENTS Member, Neurospora panel, EPA Gene-Tox Data Review Committee, 1980-1982 Member Neurospora panel, EPA Aneuploidy Data Review Committee, 1984-1985

Member, Working Group of IARC Monograph Vol. 38 on the Carcinogenicity of Tobacco Smoke, International Agency for Research on Cancer, Lyon, France, 1985

Secretary and Member, Board of Directors, Genotoxicity and Environmental Mutagen Society (GEMS), 1983-1985

Vice-President, GEMS, 1987-1988 President, GEMS, 1988-1989 Councilor, Environmental Mutagen Society, 1988-1991

Chair, Working Group on Hazard Identification, Comparative Risk Assessment Associated with Exposure of Human and Nonhuman Biota to Genotoxic Agents and Ionizing Radiation, International Commission for Protection Against Environmental Mutagens and Carcinogens (ICPEMC), December 7-14, 1990 at Belleville, France; May 20-23,1991 at Harpers Ferry, WV; October 21-23, 1991 at Livermore, CA; January 11-13, 1992 at Belleville, France

Member, Working Group on Hazard Identification, Drinking Water and Health in the Year 2000 Workshop, Breckenridge, CO, July 14-17, 1991 Chair, Future Directions Committee (1992-1993), Alexander Hollaender Fund for International Programs (1993-1995), and Publications Policy Committee (1996-1997) of the EMS

6 Member, Standing NHEERL Symposium Committee, 1998-present Member, NERL/NHEERL Interaction Committee, 1998-present

Member, US EPA Technical Qualifications Review Panel, 1994-1998. President-Elect, Environmental Mutagen Society, 2000-2001. President, Environmental Mutagen Society, 2001-2002.

Member, Proteomics Steering Committee, National Research Council, National Academy of Sciences, “Defining the Mandate of Proteomics in the Post-Genomics Era,” February 2002, Wash., DC.

Member, Working Group of IARC Monograph Vol. 83 “Tobacco Smoking and Cancer,” Chair of Mechanisms Sub-group, June 2002, IARC, Lyon, France.

Member, Working Group for IARC Monograph Vol. 84 “Some Drinking-Water Disinfectants and Contaminants, including Arsenic,” Chair of Mechanisms Sub-group, October 2002, IARC, Lyon, France

Chair, Program Committee, 9th International Conference on Environmental Mutagens (9th ICEM), September, 2005, San Francisco

President, International Association of Environmental Mutagen Societies (IAEMS) 2006-2009.

Member, Working Group on IARC Monograph Vol. 95 “Indoor Air Pollution Due to Cooking and Heating with Coal, Wood, or Dung,” Chair of Mechanisms Sub-group, October 2006, IARC, Lyon, France. Member, Workshop on High-Priority Carcinogens, IARC, June, 2009, Lyon, France Member, Working Group on “Carcinogenicity of Human Carcinogens” for IARC Monograph Vol. 100, September 28 – October 7, 2009, IARC, Lyon, France. Chair, IARC Monograph Vol. 101, February 15-22, 2011 “Some Chemicals in Industrial and Consumer Products, Food Contaminants, and Water Chlorination By-products,” Lyon, France Member, Working Group on “Carcinogenicity of Automobile and Diesel Exhaust,” IARC Monograph Vol. 105, Chair of Mechanisms Sub-group, June 2012, Lyon, France.

7 Member, Working Group on Evaluation of Tumor Concordance and Mechanisms of Human Carcinogens” for IARC, April and November, 2012, Lyon, France Member, Working Group on IARC Monograph 109 “Carcinogenicity of Ambient Air,” Chair of Mechanisms Sub-group, October 2013, Lyon, France.

Secretary, UNC Chapter of Sigma Xi, April 2013-present. Member, Advisory Panel, IARC, April 2014, Lyon, France. PROFESSIONAL ORGANIZATIONS American Association for the Advancement of Science (AAAS, 1974-present) Environmental Mutagenesis and Genomics Society (EMGS, 1974-present) Genetics Society of America (GSA, 1976-2004) Society of the Sigma Xi (1976-present) Genetics and Environmental Mutagenesis Society (GEMS, 1984-present) PUBLICATIONS Journal Articles 1. DeMarini, D.M., C.P. Kurtzman, D.I. Fennell, K.A. Worden, and R.W. Detroy (1977) Transmission of PsV-F and PsV-S mycoviruses during conidiogenesis of Penicillium stoloniferum, J. Gen. Microbiol., 100, 59-64. 2. Detroy, R.W., D.M. DeMarini, and P.E. Still (1978) Mycoviruses of Penicillium stoloniferum: influence of carbon-nitrogen nutrition upon replication, Can. J. Microbiol., 24, 947-953. 3. Pham, H.N., D.M. DeMarini, and H.E. Brockman (1979) Mutagenicity of skin tanning lotions, J. Environ. Pathol. Toxicol., 3, 227-231. 4. DeMarini, D.M. (1981) Mutagenicity of cigarette smoke condensate in Neurospora crassa, Mutat. Res., 88, 363-374. 5. DeMarini, D.M. (1981) Mutagenicity of fractions of cigarette smoke condensate in Neurospora crassa and Salmonella typhimurium, Mutat. Res., 88, 375-388. 6. Heartlein, M.W., D.M. DeMarini, A.J. Katz, J.C. Means, M.J. Plewa, and H.E. Brockman (1981) Mutagenicity of municipal water obtained from a rural area, Environ. Mutagen., 3, 519-530.

8 7. DeMarini, D.M., M.J. Plewa, and H.E. Brockman (1982) Use of four short-term tests to evaluate the mutagenicity of municipal water, J. Toxicol. Environ. Health, 9, 127-140. 8. DeMarini, D.M. (1983) Genotoxicity of tobacco smoke and smoke condensate, Mutat. Res., 114, 59-89. 9. DeMarini, D.M., S. Croz, C. Paoletti, P. Lecointe, and A.W. Hsie (1983) Mutagenicity and cytotoxicity of five antitumor ellipticines in mammalian cells and their structure-activity relationships in Salmonella, Cancer Res., 43, 3544-3552. 10. Brockman, H.E., F.J. de Serres, T.-M. Ong, D.M. DeMarini, A.J. Katz, F. Griffiths, and R.S. Stafford (1984) Mutation tests in Neurospora crassa: A report of the U.s. Environmental Protection Agency Gene-Tox Program, Mutat. Res., 133, 87-134. 11. DeMarini, D.M., P.A. Brimer, and A.W. Hsie (1984) Cytotoxicity and mutagenicity of coal oils in the CHO/HGPRT assay, Environ. Mutagen., 6, 517-527. 12. DeMarini, D.M., H.N. Pham, A.J. Katz, and H.E. Brockman (1984) Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium, Mutat. Res., 136, 185-199. 13. Griffiths, A.J.F., H.E. Brockman, D.M. DeMarini, and F.J. de Serres (1986) The efficacy of Neurospora in detecting agents that cause aneuploidy, Mutat. Res., 167, 35-45. 14. DeMarini, D.M., K.H. Brock, C.L. Doerr, and M.M. Moore (1987) Mutagenicity and clastogenicity of teniposide (VM-26) in L5178Y/TK+/- -3.7.2C mouse lymphoma cells, Mutat. Res., 187, 141-149. 15. Moore, M.M., K.H. Brock, C.L. Doerr, and D.M. DeMarini (1987) Mutagenesis of L5178Y/TK+/- -3.7.2C mouse lymphoma cells by the clastogen ellipticine, Environ. Mutagen., 9, 161-170. 16. DeMarini, D.M., D.J. Brusick, and J. Lewtas (1987) Use of limited protocols to evaluate the genotoxicity of hazardous wastes in mammalian cell assays: Comparison to Salmonella, J. Toxicol., Environ. Health, 22, 225-239. 17. Houk, V.S., and D.M. DeMarini (1987) Induction of prophage lambda by chlorinated pesticides, Mutat. Res., 182, 193-201. 18. Moore, M.M., K.H. Brock, C.L. Doerr, and D.M. DeMarini (1987) Mutagenicity of adriamycin in L5178Y/TK+/- -3.7.2C mouse lymphoma cells, Mutat. Res., 191, 183-188. 19. DeMarini, D.M., J.P. Inmon, J.E. Simmons, E. Berman, T.C. Pasley, S.H. Warren, and R.W. Williams (1987) Mutagenicity in Salmonella of hazardous wastes and urine from rats fed these wastes, Mutat. Res., 189, 205-216.

9 20. DeMarini, D.M., C.L. Doerr, M.K. Meyer, K.H. Brock, J. Hozier, and M.M. Moore (1987) Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic effects: Possible role of topisomerase, Mutagenesis, 2, 349-355. 21. DeMarini, D.M., K.H. Brock, C.L. Doerr, and M.M. Moore (1987) Mutagenicity of actinomycin D in mammalian cells due to clastogenic effects, Mutat. Res., 192, 151-155. 22. Houk, V.S., and D.M. DeMarini (1988) Use of the Microscreen phage-induction assay to assess the genotoxicity of 14 hazardous industrial wastes, Environ. Mol. Mutagen., 11, 13-29. 23. DeMarini, D.M., K.H. Brock, C.L. Doerr, and M.M. Moore (1988) Mutagenicity and clastogenicity of proflavin in L5178Y/TK+/- -3.7.2C cells, Mutat. Res., 204, 323-328. 24. Ripley, L.S., J.S. Dubins, J.G. deBoer, D.M. DeMarini, A.M. Bogerd, and K.N. Kreuzer (1988) Hotspot sites for acridine-induced frameshift mutations in bacteriophage T4 correspond to sites of action of the T4 type II topoisomerase, J. Mol. Biol., 200, 665-680. 25. Simmons, J.E., D.M. DeMarini, and E. Berman (1988) Lethality and hepatotoxicity of complex waste mixtures, Environ. Res., 46, 74-85. 26. Brockman, H.E., and D.M. DeMarini (1988) Utility of short-term tests for genetic toxicity in the aftermath of the NTP's analysis of 73 chemicals, Environ. Mol. Mutagen., 11, 421-435. 27. DeMarini, D.M., and B.K. Lawrence (1988) Mutagenicity of topoisomerase-active agents in bacteriophage T4, Teratogen. Carcinogen. Mutagen., 8, 293-301. 28. DeMarini, D.M., H.E. Brockman, F.J. de Serres, H.H. Evans, L.F. Stankowski, and A.W. Hsie (1989) Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective, Mutat. Res., 220, 11-29. 29. DeMarini, D.M., J.E. Gallagher, V.S. Houk, and J.E. Simmons (1989) Toxicological evaluation of complex industrial wastes: Implications for exposure assessment, Toxicol. Lett., 49, 199-214. 30. Huff, J.E., J.K. Haseman, D.M. DeMarini, S. Eustis, R.R. Maronpot, A.C. Peters, R.L. Pershing, C.E. Chrisp, and A.C. Jacobs (1989) Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice, Environ. Health Perspect., 82, 125-163. 31. DeMarini, D.M., J. Lewtas, and H.E. Brockman (1989) Utility of short-term tests for genetic toxicity, Cell Biol. Toxicol., 5, 189-200. 32. DeMarini, D.M., M.M. Dallas, and J. Lewtas (1989) Cytotoxicity and effect on mutagenicity of buffers in a microsuspension assay, Teratogen. Carcinogen. Mutagen., 9, 287-295.

10 33. DeMarini, D.M., and J.E. Simmons (1989) Toxicological evaluation of by-products from chemically dechlorinated 2,3,7,8-TCDD, Chemosphere 18, 2293-2301. 34. Linak, W.P., J.V. Ryan, E. Perry, R.W. Williams, and D.M. DeMarini (1989) Chemical and biological characterization of products of incomplete combustion from the simulated field burning of agricultural plastic, J. Air Pollut. Control Assoc., 39, 836-846. 35. DeMarini, D.M., H.G. Brooks, and D.G. Parkes, Jr. (1990) Induction of prophage lambda by chlorophenols, Environ. Mol. Mutagen., 15, 1-9. 36. Lewtas, J., J.E. Gallagher, and D.M. DeMarini (1990) Environmental mutagens and risk assessment, Environ. Mutagen. Res. Commun., 12, 1-9. 37. Lewtas, J., L.C. King, K. Williams, L.M. Ball, and D.M. DeMarini (1990) Bioassay-directed fractionation of 1-nitropyrene metabolites: Generation of mutagrams by coupling reverse-phase HPLC with microsuspension mutagenicity assays, Mutagenesis, 5, 481-489. 38. Backer, L.C., J.W. Allen, K. Harrington-Brock, J.A. Campbell, D.M. DeMarini, C.L. Doerr, D.R. Howard, A.D. Kligerman, and M.M. Moore (1990) Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro, Mutagenesis, 5, 541-547. 39. Bell, D.A., J.G. Levine, and D.M. DeMarini (1991) DNA sequence analysis of revertants of the hisD3052 allele of Salmonella typhimurium TA98 using the polymerase chain reaction and direct sequencing: Application to 1-nitropyrene-induced revertants, Mutat. Res., 252, 35-44. 40. Linak, W.P., J.A. McSorley, R.E. Hall, R.K. Srivastava, J.V. Ryan, J.A. Mulholland, M.G. Nishioka, J. Lewtas, and D.M. DeMarini (1991) Application of staged combustion and reburning to the co-firing of nitrogen-containing wastes, Hazard. Waste Hazard. Materials, 8, 1-15. 41. DeMarini, D.M., V.S. Houk, J. Lewtas, R.W. Williams, M.G. Nishioka, R.K. Srivastava, J.V. Ryan, J.A. McSorley, R.E. Hall, and W.P. Linak (1991) Measurement of mutagenic emissions from the incineration of the pesticide dinoseb during the application of combustion modifications, Environ. Sci. Technol., 25, 910-913. 42. DeMarini, D.M., B.K. Lawrence, H.G. Brooks, and V.S. Houk (1991) Compatibility of organic solvents with the Microscreen prophage-induction assay: Solvent-mutagen interactions, Mutat. Res., 263, 107-113. 43. Bell, D.A., and D.M. DeMarini (1991) Excessive cycling converts PCR products to random-length higher molecular weight fragments, Nucleic Acids Res., 19, 5079. 44. DeMarini, D.M., and H.G. Brooks (1992) Induction of prophage lambda by chlorinated organics: Detection of some single-species/single-site carcinogens, Environ. Mol. Mutagen., 19, 98-111.

11 45. DeMarini, D.M., and B.K. Lawrence (1992) Prophage induction by DNA topoisomerase II poisons and reactive-oxygen species: Role of DNA breaks, Mutat. Res., 267, 1-17. 46. DeMarini, D.M., R.W. Williams, E. Perry, P.M. Lemieux, and W.P. Linak (1992) Bioassay-directed chemical analysis of organic extracts of emissions from a laboratory-scale incinerator: Combustion of surrogate compounds, Combust. Sci. Technol., 85, 437-453. 47. DeMarini, D.M., R.W. Williams, L.R. Brooks, and M.S. Taylor (1992) Use of cyanopropyl-bonded HPLC column for bioassay-directed fractionation of organic extracts from incinerator emissions, Intern. J. Environ. Anal. Chem., 48, 187-199. 48. Watts, R.R., P.M. Lemieux, R.A. Grote, R.W. Lowans, R.W. Williams, L.R. Brooks, S.H. Warren, D.M. DeMarini, D.A. Bell, and J. Lewtas (1992) Development of source testing, analytical, and mutagenicity bioassay procedures for evaluating emissions from municipal and hospital waste combustors, Environ. Health Perspect., 98, 227-234. 49. DeMarini, D.M., A. Abu-Shakra, R. Gupta, L.J. Hendee, and J.G. Levine (1992) Molecular analysis of mutations induced by the intercalating agent ellipticine at the hisD3052 allele of Salmonella typhimurium TA98, Environ. Mol. Mutagen., 20, 12-18. 50. DeMarini, D.M., V.S. Houk, A. Kornel, and C.J. Rogers (1992) Effect of a base-catalyzed dechlorination process on the genotoxicity of PCB-contaminated soil, Chemosphere, 24, 1713-1720. 51. DeMarini, D.M., D.A. Bell, J.G. Levine, M.L. Shelton, and A. Abu-Shakra (1993) Molecular analysis of mutations induced at the hisD3052 allele of Salmonella by single chemicals and complex mixtures, Environ. Health Perspect., 101 (Suppl. 3), 207-212. 52. Bull, R.J., R.B. Conolly, D.M. DeMarini, R.C. MacPhail, E.V. Ohanian and J.A. Swenberg (1993) Incorporating biologically based models into assessments of risk from chemical contaminants, J. Am. Water Works Assoc. 85(3), 49-52. 53. DeMarini, D.M. (1994) Induction of mutation spectra by complex mixtures: Approaches, problems, and possibilities, Environ. Health Perspect., 102 (Suppl. 4), 127-130. 54. DeMarini, D.M., and J. Lewtas (1995) Mutagenicity and carcinogenicity of complex combustion emissions: Emerging molecular data to improve risk assessment. Toxicol. Environ. Chem., 49, 157-166. 55. Shelton, M.L., J. Ashby, and D.M. DeMarini (1994) Mutation spectrum of a binary mixture of mutagens (methapyrilene and sodium azide) in strain TA1535 of Salmonella. Mutat. Res., 323, 35-39.

12 56. DeMarini, D.M., P.M. Lemieux, J.V. Ryan, L.R. Brooks, and R.W. Williams (1994) Mutagenicity and chemical analysis of emissions from the open burning of scrap rubber tires, Environ. Sci. Technol., 28, 136-141. 57. Levine, J.G., R.M. Schaaper, and D.M. DeMarini (1994) Complex frameshift mutations mediated by plasmid pKM101: Mutational mechanisms deduced from 4-aminobiphenyl-induced mutation spectra in Salmonella, Genetics, 136, 731-746. 58. Levine, J.G., Knasmüller, M.L. Shelton, and D.M. DeMarini (1994) Mutation spectra of Glu-P-1 in Salmonella: Induction of hotspot frameshifts and site-specific base substitutions, Environ. Mol. Mutagen., 24, 11-22. 59. DeMarini, D.M., E. Perry, and M.L. Shelton (1994) Dichloroacetic acid and related compounds: Induction of prophage in E. coli and mutagenicity and mutation spectra in Salmonella TA100. Mutagenesis, 9, 429-437. 60. DeMarini, D.M., M.L. Shelton, and D.A. Bell (1994) Mutation spectra in Salmonella of complex mixtures: Comparison of urban air to benzo[a]pyrene, Environ. Mol. Mutagen., 24, 262-275. 61. Taylor, M.S., R.W. Setzer, and D.M. DeMarini (1995) Examination of the additivity assumption using the spiral and standard Salmonella assays to evaluate binary combinations of mutagens, Mutat. Res., 335, 1-14. 62. DeMarini, D.M., M.L. Shelton, and L.F. Stankowski Jr. (1995) Mutation spectra in Salmonella of sunlight, white fluorescent light, and light from tanning salon beds: Induction of tandem mutations and role of DNA repair, Mutat. Res., 327, 131-149. 63. Shelton, M.L., and D.M. DeMarini (1995) Mutagenicity and mutation spectra of 2-acetylaminofluorene at frameshift and base-substitution alleles in four DNA repair backgrounds of Salmonella, Mutat. Res., 327, 75-86. 64. Watanabe, T., M.J. Kohan, D. Walsh, L.M. Ball, D.M. DeMarini and J. Lewtas (1995) Mutagenicity of nitrodibenzopyranones in the Salmonella plate-incorporation and microsuspension assays, Mutat. Res., 345, 1-9. 65. DeMarini, D.M., M.L. Shelton and D.A. Bell (1996) Mutation spectra of chemical fractions of a complex mixture: Role of nitroarenes in the mutagenicity of municipal waste incinerator emissions, Mutat. Res., 349, 1-20. 66. DeMarini, D.M., M.L. Shelton and J.G. Levine (1995) Mutation spectrum of cigarette smoke condensate in Salmonella: Comparison to mutations in smoking-associated tumors, Carcinogenesis, 16, 2535-2542.

13 67. DeMarini, D.M., A. Abu-Shakra, C.F. Felton, K.S. Patterson and M.L. Shelton (1995) Mutation spectra in Salmonella of chlorinated, chloraminated, or ozonated drinking water extracts: Comparison to MX, Environ. Mol. Mutagen., 26, 270-285. 68. DeMarini, D.M. (1996) Molecular analysis of mutations induced by environmental mutagens in Salmonella: Comparison to mutations in human tumors, African Newsletter on Occupational Health and Safety, 6 (Suppl. 1), 5-8. 69. Woodall Jr., G.W., W.C. Dauterman and D.M. DeMarini (1996) Effect of dietary casein levels on activation of promutagens in the spiral Salmonella mutagenicity assay. I. Studies with noninduced rat liver S9. Mutat. Res., 360, 115-126. 70. Woodall Jr., G.W., W.C. Dauterman and D.M. DeMarini (1996) Effect of dietary casein levels on activation of promutagens in the spiral Salmonella mutagenicity assay. II. Studies with induced rat liver S9. Mutat. Res., 360, 127-143. 71. Sexton K., B.D. Beck, E. Bingham, J.D. Brain, D.M. DeMarini, R.C. Hertzberg, E.J. O'Flaherty and J.G. Pounds (1995) Chemical mixtures from a public health perspective: the importance of research for informed decision making. Toxicology 105:429-441. 72. Rothman, N., R.B. Hayes, T.V. Zenser, D.M. DeMarini, W. Bi, A. Hirvonen, G. Talaska, V.K. Bhatnagar N.E. Caporaso, L.R. Brooks, V. Lakshmi, P. Feng, S.K. Kashyap, X. You, B.T. Eischen, R. Kashyap, M.L. Shelton, F. Hsu, M. Jaeger, D.J. Parikh, B.B. Davis, S. Yin and D.A. Bell (1996) The glutathione S-transferase M1 (GSTM1) null genotype and benzidine-associated bladder cancer, urine mutagenicity and exfoliated urothelial cell DNA adducts. Cancer Epidemiol. Biomarkers & Prevent., 5:979-983. 73. DeMarini, D.M., L.R. Brooks, V.K. Bhatnagar, R.B. Hayes, B.T. Eischen, M.L. Shelton, T.V. Zenser, G. Talaska, S.K. Kashyap, M. Dosemeci, R. Kasyap, D.J. Parikh, V. Lakshmi, F. Hsu, B.B. Davis, M. Jaeger and N. Rothman (1997) Urinary mutagenicity as a biomarker in benzidine-exposed workers: Correlation with urinary metabolites and urothelial DNA adducts. Carcinogenesis, 18, 981-988. 74. DeMarini, D.M., S.B. Hastings, L.R. Brooks, B.T. Eischen, D.A. Bell, M.A. Watson, J.S. Felton, R. Sandler, and L. Kohlmeier (1997) Pilot study of free and conjugated urinary mutagenicity during consumption of pan-fried meats: possible modulation by cruciferous vegetables, glutathione-S-transferase M1, and N-acetyltransferase-2, Mutat. Res., 381, 83-96. 75. DeMarini, D.M., M.L. Shelton, S.H. Warren, T.M. Ross, J.-Y. Shim, A.M. Richard, and R.A. Pegram (1997) Glutathione S-transferase-mediated induction of GC 6 AT transitions by halomethanes in Salmonella. Environ. Mol. Mutagen., 30, 440-447. 76. DeMarini, D.M. (1998) Mutation spectra of complex mixtures, Mutation Res., 411, 11-18.

14 77. Tian, D., Z. Feng, N.M. Hanley, R.W. Setzer, J.L. Mumford and D.M. DeMarini (1998) Field cancerization of esophageal carcinoma: Multifocal accumulation of p53 protein, Int. J. Cancer, 78, 568-575. 78. DeMarini, D.M., M.L. Shelton, A. Abu-Shakra, A. Szakmary and J.G. Levine (1998) Spectra of spontaneous frameshift mutations at the hisD3052 allele of Salmonella typhimurium in four DNA repair backgrounds, Genetics, 149, 17-36. 79. DeMarini, D.M. (1998) Dietary interventions of human carcinogenesis, Mutat. Res., 400, 457-465. 80. Kligerman, A.D., D.M. DeMarini, C.L. Doerr, N.M. Hanley, V.S. Milholland, and A.H. Tennant (1999) Comparison of cytogenetic effects of 3,4-epoxy-1-butene and 1,2:3,4-diepoxybutane in mouse, rat, and human lymphocytes following in vitro Go exposure, Mutat. Res., 439, 13-23. 81. Landi, S., N.M. Hanley, A.D. Kligerman, D.M. DeMarini (1999) Induction of sister chromatid exchanges in human peripheral blood lymphocytes by bromoform: investigation of the role of GSTT1-1 polymorphism, Mutat. Res., 429, 261-267. 82. Landi, S., N.M. Hanley, S.H. Warren, R.A. Pegram, D.M DeMarini (1999) Induction of genetic damage in human lymphocytes and mutations in Salmonella by trihalomethanes: role of red blood cells and GSTT1-1 polymorphism, Mutagenesis, 14, 479-482. 83. Ohe, T., D.T. Shaughnessy, S. Landi, Y. Terao, H. Sawanishi, H. Nukaya, K. Wakabayashi, D.M. DeMarini (1999) Mutation spectra in Salmonella TA98, TA100, and TA104 of two phenylbenzotriazole mutagens (PBTA-1 and PBTA-2) detected in the Nishitakase River in Kyoto, Japan, Mutat. Res., 429, 189-198. 84. Woodall Jr., G.M., W.C. Dauterman, W.M. Hagler Jr., D.M. DeMarini (1999) Cytosol is required for the modulation by dietary casein of the hepatic microsomal activation of aflatoxin B1 to mutagenic metabolites detectable in Salmonella, Mutagenesis, 14, 365-373. 85. Evans, H.H., and D.M. DeMarini (1999) Ionizing radiation-induced mutagenesis: radiation studies in Neurospora predictive for results in mammalian cells, Mutat. Res., 437, 135-150. 86. Shaughnessy, D.T., Ohe, S. Landi, S.H. Warren, A.M. Richard, T. Munter, R. Franzen, L. Kronberg, and D.M. DeMarini (2000) Mutation spectra of the drinking water mutagen 3-chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF) in Salmonella TA100 and TA104: comparison to MX, Environ. Mol. Mutagen., 35, 106-113. 87. DeMarini, D.M., S. Landi, T. Ohe, D.T. Shaughnessy, R. Franzen, and A.M. Richard (2000) Mutation spectra in Salmonella of analogues of MX: implications of chemical structure for mutational mechanisms, Mutat. Res., 453, 51-65.

15 88. DeMarini, D.M. (2000) Influence of DNA repair on mutation spectra in Salmonella, Mutat. Res., 450, 5-17. 89. DeMarini, D.M., M.L. Shelton, M.J. Kohan, E.E. Hudgens, T.E. Kleindienst, L.M. Ball, D. Walsh, J.G. de Boer, L. Lewis-Bevan, J.R. Rabinowitz, L.D. Claxton, J. Lewtas (2000) Mutagenicity in lung of Big Blue mice and induction of tandem-base substitutions in Salmonella by the air pollutant peroxyacetyl nitrate (PAN): predicted formation of intrastrand cross-links, Mutat. Res., 457, 41-55. 90. Shaughnessy, D.T., R.W. Setzer, D.M. DeMarini (2001) Effect of the antimutagens vanillin and cinnamaldehyde on the spontaneous mutation spectra of Salmonella TA104, Mutat. Res., 480-481, 51-69. 91. Klein, P., E. Glazer, L. Grogan, M. Keane, S. Lipkowitz, P. Soballe, L. Brooks, J. Jenkins, S.M. Steinberg, D.M. DeMarini, I. Kirsch (2001) Biomarker assays in nipple aspirate fluid, The Breast J., 7, 378-387. 92. DeMarini, D.M., S. Landi, D. Tian, N.M. Hanley, X. Li, F. Hu, B.C. Roop, M.J. Mass, P. Keohavong, W. Gao, M. Olivier, P. Hainaut, J.L. Mumford (2001) Lung tumor KRAS and P53 mutations in non-smokers reflect exposure to PAH-rich coal combustion emissions, Cancer Res., 61, 6679-6681. 93. S. Porwollik, R.M.-Y. Wong, Sims, S.H., R.M. Schaaper, D.M. DeMarini, M. McClelland (2001) The ΔuvrB mutations in the Ames strains of Salmonella span 15 - 119 genes, Mutat. Res., 483, 1-11. [Corrigendum, Mutat. Res., 484, 107-110, 2001.] 94. F. Gemignani, S. Landi, D.M. DeMarini, R. Kole (2001) Spontaneous and MNNG-induced reversion of an EGFP construct in HeLa cells: an assay for observing mutations in living cells by fluorescent microscopy, Human Mutat., 18, 526-534. 95. P.A. Thompson, D.M. DeMarini, F.F. Kadlubar, G.Y. McClure, L.R. Brooks, B.L. Green, M.Y. Fares, A. Stone, P.D. Josephy, C.B. Ambrosone (2002) Evidence for the presence of mutagenic aryl amines in human breast milk and DNA adducts in exfoliated breast-duct epithelial cells, Environ. Mol. Mutagen., 39, 134-142. 96. P. Keohavong, Q. Lan, W.-M. Gao, D.M. DeMarini, M.J. Mass, X.-M. Li, B.C. Roop, J. Weissfeld, D. Tian, J.L. Mumford (2003) K-ras gene in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China, Lung Cancer, 41, 21-27. 97. S. Landi, A. Naccarati, N.M. Hanley, L. Daley, R. Devlin, M. Vasquez, M.K. Ross, R.A. Pegram, D.M. DeMarini (2003) Induction of DNA strand breaks by trihalomethanes in primary human lung epithelial cells, Mutat. Res., 538, 41-50. 98. T. Ohe, P.A. White, D.M. DeMarini (2003) Mutagenic characteristics of river waters flowing through large metropolitan areas in north America. Mutat. Res., 534, 101-112.

16 99. C.A. Granville, N.M. Hanley, J.L. Mumford, D.M. DeMarini (2003) Mutation spectra of smoky coal combustion emissions in Salmonella reflect the TP53 and KRAS mutations in lung tumors from smoky coal-exposed individuals. Mutat. Res., 525, 77-83. 100. U. Peters, D.M. DeMarini, R. Sinha, L.R. Brooks, S. Warren, N. Chatterjee, N. Rothman (2003) Urinary mutagenicity and colorectal adenoma risk. Cancer Epidemiol. Biomarkers Prevent., 12, 1253-1256. 101. U. Peters, R. Sinha, N. Rothman, D.A. Bell, M. Kulldorff, L.R. Brooks, S.H. Warren, D.M. DeMarini (2004) Urinary mutagenesis and red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding study. Environ. Mol. Mutagen., 43, 53-74. 102. R. Tornero-Velez, M.K. Ross, C. Granville, J. Laskey, J.P. Jones, D.M. DeMarini, M.V. Evans (2004) Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropane, Drug Metabol. Disposition 32: 123-131. 103. A.D. Kligerman, C.L. Doerr, A.H. Tennant, K. Harrington-Brock, J.W. Allen, E. Winkfield, P. Poorman-Allen, B. Kundu, K. Funasaka, B.C. Roop, M.J. Mass, D.M. DeMarini (2003) Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations, Environ. Mol. Mutagen., 42, 192-205. 104. D.M. DeMarini, L.R. Brooks, S.H. Warren, T. Kobayashi, M.I. Gilmour, P. Singh (2004) Bioassay-directed fractionation and Salmonella mutagenicity of automobile and forklift diesel exhaust particles, Environ. Health Perspect., 112, 814-819. 105. P. Singh, D.M. DeMarini, C.A.J. Dick, D. Tabor, J. Ryan, W.P. Linak, M.I. Gilmour (2004) Physicochemical characterization and pulmonary toxicity in mice of automobile and forklift diesel exhaust particles, Environ. Health Perspect., 112, 820-825. 106. B. Kundu, S.D. Richardson, P.D. Swartz, P.P. Matthews, A.M. Richard, D.M. DeMarini (2004) Mutagenicity in Salmonella of halonitromethanes: a recently recognized class of disinfection by-products in drinking water, Mutat. Res., 562, 39-65. 107. B. Kundu, S.D. Richardson, C.A. Granville, D.T. Shaughnessy, N.M. Hanley, A.M. Richard, D.M. DeMarini (2004) Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra, Mutat. Res., 554, 335-350. 108. M. Kato, D.M. DeMarini, A.B. Carvalho, M.A.V. Rego, A.V. Andrade, A.S.V. Bomfim, D. Loomis (2005) World at work: Charcoal-producing industries in northeastern Brazil, Occupat. Environ. Med., 62:128-132.

17 109. M. Kato, D. Loomis, L.M. Brooks, G.F.J. Gattas, L. Gomes, A.B. Carvalho, M.A.V. Rego, D.M. DeMarini (2004) Urinary biomarkers in charcoal workers exposed to wood smoke in Bahia State, Brazil, Cancer Epidemiol. Biomarkers Prevent., 13, 1005-1012. 110. D.M. DeMarini (2004) Genotoxicity of tobacco smoke and tobacco smoke condensate: a review, Mutat. Res., 567, 447-474. 111. P. Andrewes, D.M. DeMarini, K. Funasaka, K. Wallace, V.W.M. Lai, H. Sun, W.R. Cullen, K.T. Kitchen (2004) Do arsenosugars pose a risk to human health? The comparative toxicities of a trivalent and pentavalent arsenosugar, Environ. Sci. Technol, 38, 4140-4148. 112. Q. Lan, J.L. Mumford, M. Shen, D.M. DeMarini, M.R. Bonner, Z. He, M. Yeager, R. Welch, S. Chanock, L. Tian, R.S. Chapman, T. Zheng, P. Keohavong, N. Caporaso, N. Rothman (2004) Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions, Carcinogenesis, 25, 2177-2181. 113. J.M. Samet, D.M. DeMarini, H.V. Malling (2004) Could inhaled particulate air pollution cause heritable mutations?, Science, 304, 971-972. 114. NA van Larebeke, LS Birnbaum, MA Boogaerts, M Bracke, DL Davis, DM DeMarini, K Hooper, J Huff, JC Kleinjans, MS Legator, G Schoeters, K Vähäkangas (2005) Unrecognized or potential risk factors for childhood cancer. Int. J. Occupat. Environ. Health., 11, 199-201. 115. C.A. Granville, M.K. Ross, R. Tornero-Velez, N.M. Hanley, R.D. Grindstaff, A. Gold, A.M. Richard, K. Funasaka, A.H. Tennant, A.D. Kligerman, M.V. Evans, D.M. DeMarini (2005) Genotoxicity and metabolism of the source-water contaiminant 1,1-dichloropropene: activation by GSTT1-1, Mutat. Res., 572, 98-112. 116. M. Shen, N. Rothman, S.I. Berndt, D.M. DeMarini, J.L. Mumford, X. He, M.R. Bonner, L. Tian, M. Yeager, R. Welch, S. Chanock, T. Zheng, N. Caporaso, Q. Lan (2005) Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China, Int. J. Cancer, 116, 768-773. 117. D.M. DeMarini, R.J. Preston, Smoking while pregnant: transplacental mutagenesis of the fetus by tobacco smoke (2005) J. Am. Med. Assoc., 293, 1264-1265. 118. G. Sabbioni, C.R. Jones, O. Sepai, A. Hirvonen, H. Norppa, H. Jarventaus, H. Glatt, D. Pomplun, H. Yan, L.R. Brooks, S.H. Warren, D.M. DeMarini, Y.-Y. Liu (2006) Biomarkers of exposure, effect and susceptibility in workers exposed to nitrotoluenes, Cancer Epidemiol. Biomarkers Prevent., 15, 559-566. 119. C. Zwiener, S.D. Richardson, D.M. DeMarini, T. Grummt, T. Glauner, F.H. Frimmel (2007) Drowning in disinfection by-products? Assessing swimming pool water. Environ. Sci. Technol., 41, 363-372.

18 120. D.M. DeMarini, L.D. Claxton (2006) Outdoor air pollution and DNA damage. Occupat. Environ. Med., 63, 227-228. 121. G. Sabbioni, O. Sepai, H. Yan, H. Norppa, A. Hirvonen, Y. Zhen, H. Jarventaus, B. Back, L.R. Brooks, S.H. Warren, D.M. DeMarini, Y.-Y. Liu (2007) Comparison of biomarkers in workers exposed to 2,4,6-trinitrotoluene. Biomarkers, 12, 21-37. 122. C.D. Swartz, N. Parks, D.M. Umbach, W.O. Ward, R. Schaaper, D.M. DeMarini (2007) Enhanced mutagenesis of Salmonella tester strains due to deletion of genes other than uvrB, Environ. Mol. Mutagen., 48, 694-705. 123. T.D. Shaughnessy, R.M. Schaaper, D.M. Umbach, D.M. DeMarini (2006) Inhibition of spontaneous mutagenesis by vanillin and cinnamaldehyde in Escherichia coli: dependence on recombinational repair, Mutat. Res., 602, 54-64. 124. A.J. Wyrobek, J.J. Mulvihill, J.S. Wassom, H.V. Malling, M.D. Shelby, S.E. Lewis, K.L. Witt, R.J. Preston, S.D. Perreault, J.W. Allen, D.M. DeMarini, R.P. Woychik, J.B. Bishop, and Workshop Presenters (2007) Assessing human germ-cell mutagenesis in the post-genome era: A celebration of the legacy of William Lawson (Bill) Russell, Environ. Mol. Mutagen., 48, 71-95. 125. A.A. King, D.T. Shaughnessy, K. Mure, J. Leszczynska, W.O. Ward, D.M. Umbach, Z. Xu, D. Ducharme, J.A. Taylor, D.M. DeMarini, C.B. Klein (2007) Antimutagenicity of cinnamaldehyde and vanillin in human cells: gene expression and possible role of DNA damage and repair, Mutat. Res., 616, 60-69. 126. B. Sen, B. Mahadevan, D.M. DeMarini (2007) Transcriptional responses to complex mixtures—a review, Mutat. Res., 636, 144-177. 127. S.D. Richardson, M.J. Plewa, E.D. Wagner, D.C. Wolf, D.M. DeMarini, R. Schoeny (2007) Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water, Mutat. Res., 636, 178-242. 128. T.L. Leavens, R.A. Pegram, B.C. Blount, D.M. DeMarini, M.C. Madden, J.L. Valentine, M.W. Case, L.K. Silva, S.H. Warren, N.M. Hanley, R.A. Pegram (2007), Disposition of bromodichloromethane in humans following oral and dermal exposure, Toxicol. Sci., 99, 432-445. 129. W.O. Ward, C.D. Swartz, S. Porwollik, S.H. Warren, N.M. Hanley, G.W. Knapp, M. McClelland, D.M. DeMarini (2007) Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of MX-treated Salmonella, BMC Bioinformatics, 8, 378. 130. D.M. DeMarini, R. Gudi, A. Szkudlinska, M. Rao, L. Recio, M. Kehl, P.E. Kirby, G. Polzin, P.I. Richter (2008) Genotoxicity of ten cigarette smoke condensates in four test systems: comparison among assays and condensates, Mutat. Res., 650, 15-29.

19 131. C.D. Swartz, L. King, S. Nesnow, D.M. Umbach, S. Kumar, D.M. DeMarini (2009) Mutagenicity, stable DNA adducts, and abasic sites induced in Salmonella by phenanthro[3,4-b]- and phenanthro[4,3-b]thiophenes, sulfur analogs of benzo[c]phenanthrene, Mutat. Res., 661, 47- 56. 132. E. Benefenati, R. Benigni, D.M. DeMarini, C. Helma, D. Kirkland, T.M. Martin, P. Mazzatorta, G. Ouedraogo-Arras, A.M. Richard, B. Schilter, W.G.E.J. Schoonen, R.D. Snyder, C. Yang (2009) Predictive models for carcinogenicity and mutagenicity: frameworks, state-of-the-art, and perspectives, J. Environ. Sci. Health Part C 27, 1-34. 133. L.C. King, S.D. Hester, S.H. Warren, D.M. DeMarini (2009) Induction of abasic sites by the drinking-water mutagen MX in Salmonella TA100, Chem.-Biol. Interact., 180, 340-343. 134. W.O. Ward, C.D. Swartz, N.M. Hanley, J.W. Whitaker, R. Franzen, D.M. DeMarini (2010) Mutagen structure and transcriptional response: induction of distinct transcriptional profiles in Salmonella TA100 by the drinking-water mutagen MX and its homologues. Environ. Mol. Mutagen., 51, 69-79. 134. A.F. Olshan, T.J. Luben, N.M. Hanley, S.D. Perreault, R.L. Chan, A.H. Herring, P.A. Basta, D.M. DeMarini (2010) Preliminary examination of polymorphisms of GSTM1, GSTT1, and GSTZ1 in relation to semen quality, Mutat Res, 688, 41-46. 134. M.M. Pratt, L.C. King, L.D. Adams, K. John, P. Sirajuddin, O.A. Olivero, D.K. Manchester, R.J. Sram, D.M. DeMarini, M.C. Poirier (2011) Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic, Environ. Mol. Mutagen, 52, 58-68. 135. S.D. Richardson, D.M. DeMarini, M. Kogevinas, P. Fernandez, C. Lourencetti, D. Heederik, K. Meliefste, A.B. McKague, R. Marcos, L. Font-Ribera, J.O. Grimalt, C.M. Villanueva (2010) What’s in the Pool? A Comprehensive identification of disinfection by-products and assessment of mutagenicity of chlorinated and brominated swimming pool water, Environ. Health Perspect., 118, 1523-1530. 136. M. Kogevinas, C.M. Villanueva, L. Font-Ribera, D. Liviac, M. Bustamante, M. Nieuwenhuijsen, A. Epsinosa, P. Fernandez, D.M. DeMarini, J.O. Grimalt, T. Grummt, R. Marcos (2010) Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools, Environ Health Perspect., 118, 1531-1537. 137. L.D. Claxton, G.A. Umbruzeiro, D.M. DeMarini (2010) The Salmonella mutagenicity assay: the stethosocope of genetic toxicology for the 21st century, Environ. Health Perspect., 118, 1515-1522. 138. Ward EM, Schulte PA, Straif K, Hopf NB, Caldwell JC, Carreón T, DeMarini DM, Fowler BA, Goldstein BD, Hemminki K, Husgafvel Pursiainen K, Kuempel E, Lewtas J, Lunn RM,

20 Lynge E, McElvenny DM, Muhle H, Nakajima T, Robertson LW; IARC Working Group (2010) Research recommendations for selected IARC-classified agents, Environ. Health Perspect., 118, 1355-1362. 139. W.O. Ward, C.D. Swartz, N.M. Hanley, D.M. DeMarini (2010) transcriptional characterization of Salmonella TA100 in log and stationary phase: Influence of growth phase on mutagenicity of MX, Mutat. Res., 692, 19-25. 140. D.M. DeMarini, S. De Flora (2010) What’s in a name? The argument for changing the name of IAEMS and its affiliated societies, Mutat Res, 705, 201-204. 141. D.T. Shaughnessy, L.M. Gangarosa, B. Schliebe, D.M. Umbach, Z. Xu, B. MacIntosh, M.G. Knize, P.P. Matthews, A.E. Swank, R.S. Sandler, D.M. DeMarini, J.A. Taylor (2011) Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. PLoS One, 6(4), e18707. 142. J. Mo, Y. Xia, T.J. Wade, D.M. DeMarini, M. Davidson, J. Mumford (2011) Altered gene expression by low-dose arsenic exposure in humans and cultured cardiomycocytes: assessment by real-time PCR arrays, Int. J. Environ. Res. Public Health 8:2090-2108. 143. D.M. DeMarini, N.M. Hanley, S.H.Warren, L.D. Adams, L.C. King (2011) Association between mutation spectra and stable and unstable DNA adduct profiles in Salmonella for benzo[a]pyrene and dibenzo[a,l]pyrene, Mutat. Res., 714, 17-25. 144. DM DeMarini (2012) Declaring the existence of human germ-cell mutagens. Environ Mol Mutagen, 53, 166-172. 145. BC Reid, AA Ghazarian, DM DeMarini, A Sapkota, D Jack, Q Lan, D Winn, LS Birnbaum (2012) Cancer associated with indoor air pollution from solid-fuel combustion, Environ Health Perspect, 120:1495-1498. 146. CL Yauk, J Lucas Argueso, SS Auerbach, SR Davis, DM DeMarini, GR Douglas, YE Dubrova, RK Elespuru, TW Glover, BF Hales, ME Hurles, CB Klein, JR Lupski, DK Manchester, F Marchetti, A Montpetit, JJ Mulvihill, B Robaire, WA Robbins, G Rouleau, DT Shaughnessy, CM Somers, J Taylor, J Trasler, MD Waters, TE Wilson, KL Witt, JB Bishop

(2013) Harnessing New Genomics Technologies to Understand Environmental Influences on Inherited Diseases, Mutat Res, 752:6-9. 147. TE Wilson, DM DeMarini, SD Dertinger, BP Engelward, PC Hanawalt, JT MacGregor, SL Smith-Roe, KL Witt, CL Yauk, M Ljungman, JL Schwartz, CB Klein (2013) Building on the past, shaping the future: the Environmental Mutagenesis and Genomics Society, Environ. Mol Mutagen., 54:153-157. 148. RY Prasad, Wallace K, Daniel KM, Tennant AH, Zucker RM, Strickland J, Dreher K, Kligerman AD, Blackman CF, DeMarini DM (2013) Effect of treatment media on agglomeration

21 of titanium dioxide nanoparticles: impact on genotoxicity, cellular interaction, and cell cycle, ACS Nano, 7:1929-1942. 149. RY Prasad, JK McGee, MG Killius, D Ackerman, CF Blackman, DM DeMarini, SO Simmons (2013) Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: effect of size, surface coating, and intracellular uptake. Toxicol in Vitro, 27:2013-2021. 150. DM DeMarini (2013) Genotoxicity biomarkers of exposure to traffic and near-road atmospheres: a review. Mutagenesis, 28:485-505. 151. RJ Prasad, SO Simmons, MG Killius, RM Zucker, AD Kligerman, CF Blackman, RC Fry, DM DeMarini (2014) The role of cell culture media on the cellular interaction and biological response to titanium dioxide nanoparticles in hepG2 and BEAS02B cells. Environ Mol Mutagen, 55:336-342. 152. E Mutlu, SH Warren, PP Matthews, C King, WP Linak, H Deweerd, H Makarem, IM Kooter, JE Schmid, JA Ross, MI Gilmour, DM DeMarini (2013) Bioassay-directed fractionation and sub-fractionation for mutagenicity and chemical analysis of diesel exhaust particles. Environ Mol Mutagen, 54:719-736. 153. SH Warren, LD Claxton, J Diliberto, TJ Hughes, A Swank, DH Kusnierz, V Marshall, DM DeMarini (2014) Survey of the mutagenicity of surface water, sediments, and drinking water from the Penobscot Indian Nation. Chemosphere, 120, 690-696. 154. CL Yauk, MJ Aardema, J van Benthem, JB Bishop, KL Dearfield, DM DeMarini, YE Dubrova, M Honma, JR Lupski, F Marchetti, ML Meistrich, F Pacchierotti, J Stewart, MD Waters, GR Douglas (2015) Approaches for identifying germ cell mutagens: report of the 2013 IWGT workshop on germ cell assays, Mutat Res, 783, 36-54. 155. E. Mutlu, SH Warren, PP Matthews, C King, L Walsh, AD Kligerman, JE Schmid, D Janek, IM Kooter, WP Linak, MI Gilmour, DM DeMarini (2015) Health effects of soy biodiesel emissions: mutagenicity emission factors. Inhal Toxicol 27:585-596. 156. E Mutlu, SH Warren, PP Matthews, JE Schmid, IM Kooter, WP Linak, MI Gilmour, DM DeMarini (2015) Health effects of soy biodiesel emissions: bioassay-directed fractionation for mutagenicity. Inhal Toxicol 2:597-612. 157. E Mutlu, DG Nash, C King, TQ Krantz, WT Preston, IM Kooter, M Higuchi, DM DeMarini, WP Linak, MI Gilmour (2015) Generation, characterization, and comparison of diesel engine emissions from petroleum diesel and soybean biodiesel fuels and the application of an inhalation exposure system for studying their relative toxicity. Inahal Toxicol 27:515-532. 158. E Mutlu, SH Warren, SM Ebersviller, IM Kooter, JE Schmid, JA Dye, WP Linak, MI Gilmour, JJ Jetter, M Higuchi, DM DeMarini (2016) Mutagenicity and pollutant emission

22 factors of solid-fuel cookstoves: comparison to other combustion sources. Environ Health Perspect 124:974-982. 159. CL Yauk, MJ Aardema, J van Benthem, JB Bishop, KL Dearfield, DM DeMarini, YE Dubrova, M Honma, JR Lupski, F Marchetti, ML Meistrich, F Pacchierotti, J Stewart, MD Waters, GR Douglas (2015) Approaches for identifying germ-cell mutagens: Report of the 2013 IWGT Workshop on Germ-Cell Assays. Mutat Res, 783:36-54. 160. MT Smith, KZ Guyton, CF Gibbons, JM Fritz, DM DeMarini, JC Caldwell, R Kavlock, C Portier, I Rusyn, P Lambert, SS Hecht, J Bucher, R Baan, V Cogliano, K Straif (2016) Key characteristics of carcinogens as a basis for organizing mechanistic data on carcinogens. Environ Health Perspect, submitted. 161. JA Ross, GB Nelson, E Mutlu, SH Warren, MI Gilmour, DM DeMarini (2015) DNA adducts induced by in vitro activation of extracts of diesel and biodiesel exhaust particles. Inhal Toxicol 27:576-584. 162. SS Hecht, DM DeMarini (2016) Tobacco smoke and its constituents: concordance in studies of carcinogenicity and mechanisms in experimental animals and in humans. In: Tumour Concordance and Mechanisms of Carcinogenesis, IARC, Lyon, France, in press. 163. DM DeMarini (2016) Role of genotoxicity in carcinogenesis. In: Tumour concordance and Mechanisms of Carcinogenesis, IARC, Lyon, France, in press. Books Edited 1. Sandhu, S.S., D.M. DeMarini, M.J. Mass, M.M. Moore, and J.S. Mumford (Eds.) (1987) Short-Term Bioassays in the Analysis of Complex Environmental Mixtures Vol. V., Plenum, New York, pp. 409. 2. Moore, M.M., D.M. DeMarini, F.J. de Serres, K.R. Tindall Eds.) (1987) Mammalian Cell Mutagenesis, Banbury Report No. 28, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 385. 3. S. Knasmuller, D.M. DeMarini, I.T. Johnson, C. Gerhauser (Eds.) (2009) Chemoprevention of Cancer and DNA Damage by Dietary Factors, Wiley-VCH Verlag, Weinheim, Germany, pp 787. Book Chapters 1. Tennant, R.W., D.M. DeMarini, and J.W. Spalding (1987) Carcinogenicity and genetic toxicity results on single chemicals: Implications for testing mixtures, in: V.B. Vouk, G.C. Butler, A.C. Upton, D.V. Parke, and S.C. Asher (Eds.) Methods for Assessing the Effects of Mixtures of Chemicals, Wiley, Chichester, U.K., 759-774.

23 2. Moore, M.M., K.H. Brock, D.M. DeMarini, C.L. Doerr (1987) Differential recovery of induced mutants at the tk and hgprt loci in mammalian cells, in: M.M. Moore, D.M. Demarini, F.J. de Serres, and K.R. Tindall (Eds.), Mammalian Cell Mutagenesis, Banbury Report No. 28, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 93-108. 3. DeMarini, D.M., and V.S. Houk (1988) Assessment of hazardous wastes for genotoxicity, in: Proceedings of the World Conference on Hazardous Waste, R. Abbou (Ed.), Elsevier, Amsterdam, pp. 1107-1115. 4. DeMarini, D.M., J. Lewtas, and H.E. Brockman (1989) Utility of Short-term Tests, in: Benchmarks: Alternative Methods in Toxicology, M.A. Mehlman (Ed.), Princeton Scientific, Princeton, NJ, pp. 205-216. 5. DeMarini, D.M. (1991) Environmental Mutagens/Complex Mixtures, in: Genetic Toxicology, A.P. Li and R.H. Heflich (Eds.), CRC Press, Boca Raton, FL, pp. 285-302. 6. Houk, V.S., and D.M. DeMarini (1991) Characterizing the genotoxicity of hazardous industrial wastes using short-term bioassays, in: Hazardous Waste Measurements, M.S. Simmons (Ed.), Lewis Publishers, Chelsea, MI, pp. 211-245. 7. Shelby, M.D., R.R. Tice, D.M. DeMarini, and R.S.H. Yang (1990) Toxicity and mutagenicity of a mixture of 25 chemicals found in contaminated groundwater, in: Complex Mixtures and Cancer Risk, H. Vainio, M. Sorsa, and A.J. McMichael (Eds.), IARC Scientific Publications No. 104, IARC, Lyon, France, pp. 314-332. 8. Houk, V.S., and D.M. DeMarini (1990) Assessment of the Microscreen phage-induction assay for screening hazardous wastes, in: Waste Testing and Quality Assurance: Second Volume, ASTM STP 1062, D. Friedman (Ed.), American Society for Testing and Materials, Philadelphia, pp. 89-106. 9. Houk, V.S., D.M. DeMarini, R. Watts, and J. Lewtas (1993) Toxicological evaluations of hazardous effluents and emissions using genetic bioassays, in: Effective and Safe Waste Management: Interfacing Sciences and Engineering with Monitoring and Risk Analysis, R.L. Jolley and R.G.M. Wang (Eds.), Lewis Publishers, Boca Raton, FL, pp. 265-280. 10. Lewtas, J., L.C. King, and D.M. DeMarini (1994) New approaches to bioassay- and biomarker-directed identification of genotoxic components in complex mixtures: DNA adduct identification and mutation spectra, in: Toxicology of Chemical Mixtures: From Real Life Examples to Mechanisms of Toxicological Interactions, R.S.H. Yang (Ed.), Academic Press, New York, pp. 385-398. 11. DeMarini, D.M., A.M. Richard, M.D. Shelby and M.D. Waters (1994) Hazard identification, in: Methods for Genetic Risk Assessment, D.J. Brusick (Ed.), CRC Press, Boca Raton, FL, pp. 1-27.

24 12. Lewtas, J., D.M. DeMarini, J. Favor, D.W. Layton, J.T. MacGregor, J. Ashby, P.H.M. Lohman, R.H. Haynes, and M.L. Mendelsohn (1994) Risk characterization strategies for genotoxic environmental agents, in: Methods for Genetic Risk Assessment, D.J. Brusick (Ed.), CRC Press, Boca Raton, FL, pp. 125-169. 13. DeMarini, D.M., and J. Huff (1998) Genetic toxicity assessment, in: ILO Encyclopaedia of Occupational Health and Safety, 4th Ed., Vol. 1, International Labour Organization, Geneva, pp. 33.43-33.45. 14. Lemieux, P.M., J.V. Ryan, D.M. DeMarini, D.W. Bryant and B.E. McCarry (1998) Tires, Open Burning, in: Encyclopedia of Environmental Analysis and Remediation, R.A. Meyers (Ed.), Wiley & Sons, Inc., New York, 4813-4832. 15. Kohlmeier, L., D.M. DeMarini and W. Piegorsch (1997) Gene-nutrient interactions in nutritional epidemiology, in: B.M. Margetts and M. Nelson (Eds.) Design Concepts in Nutritional Epidemiology, Oxford Press, Oxford, England, pp. 312-337. 16. DeMarini, D.M. (1999) Use of mutagenicity for predicting carcinogenicity, in: Carcinogenicity: Testing, Predicting and Interpreting Chemical Effects, K.T. Kitchin (Ed.), Marcel Dekker, New York, 209-226. 17. White, P.A. and D.M. DeMarini (2000) Water-borne mutagens, in: Environmental Medicine, L. Moller (Ed.), Joint Industrial Safety Council, Sweden, 102-122. 18. Dogliotti, E., P. Hainaut, T. Hernandez, M. D'Errico and D.M. DeMarini (1998) Mutation spectra resulting from carcinogenic exposure: from model systems to cancer-related genes, in "Genes and Environment in Cancer," Ed. M. Schwab, H. Rabes, K. Munk, P.H. Hofschneider, Springer, Berlin, pp. 97-124. 19. DeMarini, D.M. Genotoxicity of tobacco smoke and tobacco smoke condensate, in Surgeon General’s Report on Smoking and Health “How Tobacco Causes Disease: The Biology and Behavioral Basis for Tobacco-Attributable Disease,” Centers for Disease Control, Atlanta, GA, 2010. 20. DeMarini, D.M. Genotoxicity of Disinfection By-products: Comparison to Carcinogenicity, in Encyclopedia of Environmental Health, Elsevier, New York, 2010. 21. Shaughnessy, D.T., DeMarini, D.M. (2009) Types and consequences of DNA damage, in Chemoprevention of Cancer and DNA Damage by Dietary Factors, S. Knasmuller, D.M. DeMarini, I.T. Johnson, C. Gerhauser (eds.), Wiley-VCH Verlag, Weinheim, Germany, pp 21-33. 22. DeMarini, D.M. (2011) Genotoxicity of disinfection by-products: comparison to carcinogenicity, in Encyclopedia of Environmental Health, Vol. 2, J.O. Nriagu (Ed.) pp 920-926, Burlington: Elsevier.

25 Technical Reports 1. DeMarini, D.M., and J.L. Epler (1983) Health effects studies, in: Proc. Workshop on Environmental Control Technology for Coal Gasification, EPRI AP-30006, Contract WS 81-241-01, Palo Alto, CA, pp. 8-1 through 8-19. 2. International Agency for Research on Cancer (IARC) (1986) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Tobacco Smoke, Vol. 38, IARC, Lyon, France, pp. 421. 3. DeMarini, D.M. (1986) Topoisomerase-mediated events--a new twist, EMS Newsletter, June, p. 9. 4. DeMarini, D.M. (1987) Batteries being recharged, EMS Newsletter, January, p. 6. 5. Moore, M.M., D.M. DeMarini, F.J. de Serres, and K.R. Tindall (1988) Meeting report on mammalian cell mutagenesis, Banbury conference, Mutat. Res., 203, 69-78. 6. DeMarini, D.M., N.Y. Kado, and J. Lewtas (1993) Analysis of mutagens by the microsuspension mutagenicity assay in Salmonella typhimurium, in: B. Seifert, H.J. Van de Wiel, B. Dodet and I.K. O'Neill (Eds.) Environmental Carcinogens: Methods of Analysis and Exposure Measurement Vol. 12 Indoor Air, IARC, Lyon, France, 300-306. 7. DeMarini, D.M., and F.C. Fuscoe (1991) Workshop report: New molecular techniques in genome analysis, Environ. Mol. Mutagen., 18, 222-223. 8. Lemieux, P.M., and D.M. DeMarini (1992) Mutagenicity of emissions from the simulated open burning of scrap rubber tires. U.S. EPA, EPA/600/R-92/127. 9. DeMarini, D.M. (1993) The Times They Are A'Changin', EMS Newsletter, July, pp. 12-13. 10. DeMarini, D.M. (1994) EMS Alexander Hollaender Training Course in Mexico City, EMS Newsletter, January, pp. 6-7. 11. DeMarini, D.M. (1994) Workshop Updates, EMS Newsletter, August, p. 6. 12. Carballo, M.A. and D.M. DeMarini (1995) Second Alexander Hollaender Training Course, EMS Newsletter, January, p. 4. 13. DeMarini, D.M. (1995) The Alexander Hollaender Fund for International Programs: Sailing Toward the Future--With Your Help, EMS Newsletter, January, pp. 5 and 13.

26 14. DeMarini, D.M. (1995) A Unique Blend of Basic and Applied Research Marks the 25th Anniversary of the U.S. Environmental Mutagen Society, PAEMS Newsletter, 2, 3. 15. Marasas, W.F.O., W.A. Anwar and D.M. DeMarini (1996) Meeting Report: The 2nd PAEMS Meeting in Cape Town, South Africa, PAEMS Newsletter, 3, 1-3. 16. DeMarini, D.M. (1996) 2nd Pan-African EMS Meeting, EMS Newsletter, July, p. 21. 17. DeMarini, D.M. (1996) 2nd Pan-African EMS Meeting, Mutat. Res. Forum 1 (2), 25-26. 18. Anwar, W., and D.M. DeMarini (1998) 4th Alexander Hollaender Training Course in Cairo, Egypt. Meeting Report in EMS Newsletter, February, pp. 16-17. 19. White, P.A., and D.M. DeMarini (1998) Proceedings of the workshop entitled "Sources, Effects, Potential Hazards of Genotoxic Complex Mixtures in the Environment." Mutat. Res., 410, 221. 20. DeMarini, D.M. (1998) Symposium and Seminar Funding in Honor of Herman E. Brockman. Meeting Report in EMS Newsletter, August, pp. 34-35. 21. G.L. Kenyon, D.M. DeMarini, E. Fuchs, D.J. Galas, J.F. Kirsch, T.S. Leyh, W.H. Moos, G.A. Petsko, D. Ringe, G.M. Rubin, L.C. Sheahan (2002) Defining the mandate of proteomics in the post-genomics era: workshop report. Mol. Cell. Proteomics, 1, 763-780. Book Reviews 1. DeMarini, D.M. (1983) Supermutagens put to the test, Environ. Mutagen., 5, 123-124. 2. DeMarini, D.M. (1986) Risky business, Environ. Mutagen., 8, 485-486. 3. DeMarini, D.M. (1990) Interior designs, Environ. Mol. Mutagen., 15, 123. 4. DeMarini, D.M. (1991) Doing the right thing, Environ. Mol. Mutagen., 17, 139. 5. DeMarini, D.M. (1992) Prelude to the present, Environ. Mol. Mutagen., 19, 182. Letters to the Editor 1. DeMarini, D.M., and M.D. Shelby (1984) Test data--how much is not enough? Environ. Mutagen., 6, 119. MEETINGS/SYMPOSIA/WORKSHOPS ORGANIZED

27

1. Co-chair of Session on Lower Eukaryotes at the 8th Annual Meeting of the Environmental Mutagen Society, Colorado Springs, CO, February 13-17, 1976.

2. Chair of Session on Microbial Mutagenicity Test Systems at the 9th Annual Meeting of the Environmental Mutagen Society, San Francisco, CA, March 9-13, 1978. 3. Co-organizer of 5th Complex Mixture Meeting sponsored by the U.S. EPA, Durham, NC, October 20-23, 1986. 4. Co-organizer of Banbury Conference "Mammalian Cell Mutagenesis," sponsored by the U.S. EPA, Cold Spring Harbor, NY, March 20-23, 1987. 5. Organizer of GEMS Fall Meeting, RTP, NC, October 11, 1987. 6. Co-organizer of Symposium on Indoor Air sponsored by GEMS, RTP, NC, May 5, 1988. 7. Co-organizer of Workshop "The Role of the Polymerase Chain Reaction in the Molecular Analysis of Mutations," 22nd Annual Meeting of the Environmental Mutagen Society, Kissimee, FL, April 6-11, 1991. 8. Co-organizer of 1st Alexander Hollaender Training Course in Genetic Toxicology, Mexico City, Mexico, November 14-17, 1993. 9. Organizer of Symposium "Molecular Genetic Toxicology" for the 25th Annual Meeting of the Environmental Mutagen Society, Portland, OR, May 7-12, 1994. 10. Co-organizer of 2nd Alexander Hollaender Training Course in Genetic Toxicology, Buenos Aires, Argentina, November 28 to December 2, 1994. 11. Organizer of 3rd Alexander Hollaender Training Course in Genetic Toxicology, Cape Town, South Africa, January 26, 1996. 12. Co-organizer of Workshop "Sources, Effects, and Potential Hazards of Genotoxic Complex Mixtures in the Environment," at the 28th Annual Meeting of the Environmental Mutagen Society, Minneapolis, MN, April 20, 1997. 13. Co-organizer of 4th Alexander Hollaender Training Course in Genetic Toxicology, Cairo, Egypt, September 15-18, 1997. 14. Organizer of 35-Year Retirement Symposium in Honor of Herman E. Brockman, Illinois State University, Normal, IL, April 17-18, 1998. 15. Organizer of 32nd Annual Meeting of the Environmental Mutagen Society, San Diego, CA,

28 March 16-21, 2001. 16. Chair, Program Committee, 9th International Conference on Environmental Mutagens (9th

ICEM), San Francisco, September 2005. 17. Co-Chair, Symposium on Mutagenicity and Carcinogenicity of Disinfection By-products in Drinking Water, 39th Meeting of the EMS, Puerto Rico, October 2008. 18. Co-Chair, Symposium on the Genotoxicity of Nanoparticles, 40th Meeting of the EMS, St. Louis, October 2009. 19. Organizer and speaker, Spring GEMS meeting on Air Pollution and Lung Cancer, April 28, 2014, RTP, NC. INVITED LECTURES 1. Have given 1-2 lectures every year on environmental mutagenesis, molecular epidemiology, epidemiology, and/or genetic toxicology at North Carolina State University, the University of North Carolina or Duke University since 1984. 2. Symposium Speaker at the 14th Annual Meeting of the Environmental Mutagen Society, San Antonio, TX, March 3-6, 1983. Genotoxicity and Carcinogenicity of Tobacco Smoke. 3. Workshop Organizer and Speaker at the 17th Annual Meeting of the Environmental Mutagen Society, Baltimore, MD, April 9-13, 1986. Differential Recovery of Gene and Chromosomal Mutations at Hemizygous vs. Heterozygous Loci. 4. Symposium Speaker at the 19th Annual Meeting of the Environmental Mutagen Society, Charleston, SC, March 27-31, 1988. Mediation of Mutagenesis by DNA Topoisomerases. 5. Lectured in the University of North Carolina's Carcinogenesis Seminar Series on May 5th, 1986. Role of DNA Topoisomerase and Chromosomal Location of Genes in the Production and Recovery of Multilocus Deletions in Mammalian Cells. 6. Fall Lecture for Genotoxicity and Environmental Mutagen Society (GEMS) at the National Institute of Environmental Health Sciences on October 3, 1986. Genetic Toxicology—A Geneticist's View. 7. Invited Lectures at the Institute of Environmental Sciences and the Genetics Department of the University of Illinois at Urbana, April, 1986. Role of DNA Topoisomerase and Gene Location in the Production of Mutations in Eukaryotic Organisms. 8. Invited Lecture at the Department of Biological Sciences at Illinois State University, Normal, IL in April, 1986. Role of DNA Topoisomerase and Gene Location in the Production of

29 Mutations in Eukaryotic Organisms. 9. Invited Lecture at the Department of Environmental Sciences at New York University, New York, NY, in April, 1987. Influence of Gene Location on the Recovery of Gene vs. Chromosomal Mutations. 10. Lectured for OAQPS's course on risk assessment at the U.S. EPA, RTP, NC, in March, 1988. 11. Symposium Lecture at the Annual Meeting of the Tissue Culture Society in Las Vegas, NV, in June, 1988. Use of Mammalian Cells for Evaluating the Genotoxicity of Complex Mixtures. 12. Symposium Lecture at the 16th Annual Toxicology Meeting sponsored by the Army/Navy in Akron, OH, in October, 1988. Characterization of Complex Hazardous Wastes by Bioassays. 13. Invited Lecture at the Department of Environmental Sciences, University of Connecticut, Storrs, CT, in March, 1989. Additivity Assumption for Risk Asssessment of Complex Mixtures. 14. Invited Lecture at Sterling-Winthrop Pharmaceutical Co., Albany, NY in April, 1989. Mediation of Mutagenesis by DNA Topoisomerases. 15. Invited Lecture at the Department of Biological Sciences and Medicine, Western Michigan University, Kalamazoo, MI, in April, 1989. Role of Gene and Chromosomal Mutations in Cancer. 16. Invited Lecture at the Department of Environmental Sciences at New York University, New York, NY, in January, 1990. Molecular Analysis of Mutations Induced by Complex Mixtures. 17. Invited Lecture at the Department of Biological Sciences, Illinois State University, Normal, IL, in April, 1990. Molecular Analysis of Mutations Induced by Complex Mixtures. 18. Invited Lecture at the Department of Environmental Science and Engineering at the University of North Carolina, Chapel Hill, NC, in February, 1990. Use of Bioassays to Characterize Complex Hazardous Wastes. 19. Invited Lecture in the Honors Seminar class in the Genetic Department at North Carolina State University, in March, 1990. How to Write a Scientific Paper. 20. Invited Lectures at the Illinois Environmental Protection Agency, Springfield, IL on July 23, 1991. Use of Bioassays to Characterize Hazardous Wastes. Molecular Mechanisms of Mutagenesis: From Mixtures to Molecules.

30 21. Invited Lecture at the Genotoxicity and Environmental Mutagen Society (GEMS) Workshop on Research Career Opportunities on September 12, 1991, U.S. EPA, RTP, NC. Research Opportunities Within the Federal Government. 22. Invited Lecture at the Biology Department, New York University, New York, NY on October 14, 1991. Molecular Mechanisms of Mutagenesis: From Mixtures to Molecules. 23. Invited Lecture at the Department of Microbiology and Molecular Genetics at the University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ on October 15, 1991. Molecular Mechanisms of Mutagenesis: From Mixtures to Molecules. 24. Invited Talk at the First International Conference on Environmental Mutagenesis in Human Populations at Risk, January 19-24, 1992, Cairo, Egypt. Molecular Mechanisms of Mutagenesis: From Mixtures to Molecules. 25. Invited Talk at "Urban Air: Emissions, Human Exposure and Risk Identification" meeting on June 1-3, 1992 in Stockholm, Sweden. Molecular Analysis of Mutations Induced in Salmonella by Urban Air and Combustion Emissions. 26. Invited Talk at "IV European ISSX Meeting, Toxicological Evaluation of Chemical Interactions: Relevance of Social, Environmental and Occupational Factors" on July 3-6, 1992 in Bologna, Italy. Combined Exposures: Should They Be Considered in the Future of Risk Assessment and Regulations? 27. Invited Talk at "Toxicology of Mixtures of Chemical Substances" on October 1, 1992 in Bethesda, MD. Emerging Methodologies for the Assessment of the Toxicology of Complex Mixtures. 28. Invited Talk at the Instituto Superiore di Sanitá on October 6, 1992 in Rome, Italy. Mutation Spectra and Molecular Mechanisms of Mutations Induced in Salmonella by Urban Air. 29. Invited Keynote Lecture at the First Annual Meeting of the Italian Section of the European Environmental Mutagen Society (Societ Italiana di Mutagenesi Ambientale or S.I.M.A.) October 7, 1992 in Pisa, Italy. Mutation Spectra and Molecular Mechanisms of Mutations Induced in Salmonella by Urban Air. 30. Invited Symposium Lectures at the 6th International Conference on Environmental Mutagens (ICEM), February 21-26, 1993 in Melbourne, Australia. Diverse Mechanisms Account for Frameshift Mutations that Revert the hisD3052 allele of Salmonella typhimurium. Urban Air Pollution: Integration of Chemical and Biological Data. 31. Invited Symposium Lecture at the Third International Congress on Toxic Combustion By- Products, June 14-16, 1993, Massachusettes Institute of Technology, Cambridge, MA. Bioassay-directed fractionation and molecular analysis of mutations induced by complex

31 combustion emissions in Salmonella. 32. Invited Symposium Lecture at the Second Annual HERL Open House, U.S. EPA, RTP, NC, June 23, 1993. Mutations Induced in Salmonella by Our Air, Drinking Water, Sunlight, and Cigarettes. 33. Invited Lecture at the OAQPS Annual Risk Assessment Forum, August 31, 1993, Washington Duke Inn, Durham, NC. Mutations Induced in Salmonella by Urban Air and Drinking Water. 34. Invited Lecture at the Institute for Tumor Biology and Cancer Research, University of Vienna, Vienna, Austria, October 4, 1993. Bioassay-Directed Fractionation and Molecular Analysis of Mutations Induced in Salmonella by Complex Environmental Mixtures: Urban Air and Drinking Water. 35. Invited Symposium Lecture at the Alexander Hollaender Meeting on Human Exposure to Toxic Substances Monitoring, Ciudad University, Mexico City, Mexico, November 14-17, 1993 and at the Annual Meeting of the Mexican Human Genetics Association, November 17 -20, 1993 in Tlaxcala, Mexico. Mutation Spectra in Salmonella: What Does It Tell Us about Mutations in Human Tumors? 36. Invited Lecture at the Biology Department, Pembroke State University, Pembroke, NC, November 16, 1993. Analysis of Mutations Induced by the Sun, Air, Drinking Water, and Cigarettes. 37. Invited Symposium Lecture in the symposium Molecular Genetic Toxicology at the 25th Annual Meeting of the Environmental Mutagen Society, Portland, OR, May 7-12, 1994. Molecular Analysis of Mutations Detected at the Frameshift Allele hisD3052 of Salmonella. 38. Invited Lecture at the National Cancer Institute, Bethesda, MD, November 17, 1994. Molecular analysis of Mutations Induced by Environmental Mutagens in Salmonella: Comparison to Mutations in Human Tumors. 39. Invited Lecture at the Dept. of Community Medicine, Mount Sinai School of Medicine, New York, NY, November 18, 1994. Molecular Analysis of Mutations Induced by Environmental Mutagens in Salmonella: Comparison to Mutations in Human Tumors. 40. Invited Symposium Lectures (3) at the Second Alexander Hollaender Training Course, University of Buenos Aires, Buenos Aires, Argentina, November 28-December 2, 1994. (1) Mutation Spectra in Salmonella, (2) Role of DNA Topoisomerase in Mutagenesis, (3) Evaluation of Short-Term Tests. 41. Invited Lecture at the Biology Department, Hope College, Holland, MI, March 10, 1995. Molecular Analysis of Mutations Induced by Environmental Mutagens in Salmonella: Comparison to Mutations in Human Tumors.

32 42. Invited Lectures at the 2nd Pan-African Environmental Mutagen Society meeting, Cape Town, South Africa, January 23-25, 1996. Mutation Spectra in Salmonella of MX and Organic Extracts of Chlorinated, Chloraminated, or Ozonated Drinking Water. Molecular Analysis of Mutations Induced by Environmental Mutagens in Salmonella: Comparison to Mutations in Human Tumors. 43. Invited Lecture at the International Conference "Recent Advances in Genetic and Molecular Toxicology" organized and sponsored by the Korean Society of Toxicology and Korean Environmental Mutagen Society (KSOT/KEMS) in Seoul, South Korea, October 11-12, 1996. The Molecular Basis for the Salmonella (Ames) Mutagenicity Assay. 44. Invited Lecture at the Latin American Association of Environmental Mutagenesis, Carcinogenesis, and Teratogenesis (ALAMCTA) meeting in Vina del Mar, Chile, November 3-7, 1996. Molecular Analysis of Mutations Induced by Environmental Mutagens in Salmonella: Comparison to Mutations in Human Tumors. 45. Invited Lecture at workshop entitled "Application of In Vitro Toxicity Assays to the Assessment of Environmental Hazards: Encouraging or Hopeless," in Tsukuba, Japan, February 13, 1997. Mutagenicity Testing of Environmental Samples: Implications of Molecular Analysis. 46. Invited Lecture at the Society of Toxicology's Annual Meeting in the SOT course entitled "Molecular Basis of Genotoxicity Assays" in Cincinnati, OH, March 9, 1997. Molecular Basis for the Salmonella (Ames) Mutagenicity Assay. 47. Workshop Lecture at the Environmental Mutagen Society meeting entitled "Bioassay- Directed Molecular Analysis of Mutations Induced in Salmonella by Complex Mixtures" in Minneapolis, MN, April 19-24, 1997. 48. Invited Lecture in workshop entitled "Quantitative Modeling Approaches for Understanding and Predicting Mutagenicity and Carcinogenicity," in Rome, Italy, September 3-5, 1997. Molecular Analysis of Mutations Induced in Salmonella by Environmental Complex Mixtures: Comparison to Mutations in Human Tumors. 49. Course Lecture at the 4th Alexander Hollaender Course in Genetic Toxicology in Cairo, Egypt, September 15-18, 1997. Molecular Basis of the Salmonella Mutagenicity Assay. 50. Invited Lecture in the Department of Toxicology's Seminar Series at North Carolina State University, Raleigh, NC, on January 6, 1998, Mutagenicity of Environmental Carcinogens. 51. Invited Lecture in the University of North Carolina's Epidemiology and Cancer Seminar Series, Chapel Hill, NC, January 15, 1998. Mutations Induced by Environmental Complex Mixtures.

33 52. Invited Symposium Lecture at the 5th Meeting of the Latin American Association on Environmental Mutagenesis, Carcinogenesis, and Teratogenesis, November 15-20, 1998, in Curitiba, Brazil. "Mutation Spectra of Complex Mixtures." 53. Invited Lecture at the 5th Alexander Hollaender Training Course in Genetic Toxicology in Curitiba, Brazil, November 15-20, 1998. "Molecular Analysis of Mutants of Salmonella." 54. Invited Lecture at the Biology Department, McMaster University, Hamilton, Ontario, Canada, December 16, 1998. "Mutation Spectra of Complex Mixtures." 55. Invited Lecture at the Third Pan-African Environmental Mutagen Society (PAEMS) conference and the 6th Alexander Hollaender Course in Genetic Toxicology in Harare, Zimbabwe, March 1-5, 1999. "Uses of the Salmonella (Ames) Mutagenicity Assay" and "Mutation Spectra of Complex Mixtures." 56. Invited Lecture at the National Institute of Standards and Technology (NIST) in Gathersberg, MD, April 2, 1999. "Mutation Spectra of Complex Environmental Mutagens." 57. Invited Lecture at the International Course on Molecular Epidemiology, Torino, Italy, November 8-13, 1999. "From DNA Damage to Mutations." 58. Invited Lecture at Health Canada, Ottawa, Canada, March 10, 2000. "Mutation Spectra in Salmonella of Complex Environmental Mixtures: Similarity to Mutations in Human Tumors." 59. Invited Lecture at the Mini-Symposium: "Chemical Mechanisms of Toxicity: Basic Knowledge for Designing Safer Chemicals" part of the Section for Medicinal Chemistry, New Swiss Chemical Society, University of Basel, Basel, Switzerland, May 4, 2000. "Mutagenesis and DNA Damage." 60. Invited Lecture in Science Reporting for Latin American Journalists, July 27-28, 2000, Santiago, Chile, “DNA, Mutations, and Cancer.” 61. Invited Lecture at the International Course on Molecular Epidemiology, IARC, Lyon, France, November 2-25, 2000. "From DNA Damage to Mutations." 62. Invited Lecture, Dept. of Environ. Sci. & Engin., UNC, Chapel Hill, October 5, 2001, “Mutational Signature in Human Tumors from Mutagens in Air and Water.” 63. Invited Lecture at the 8th International Conference on Environmental Mutagens (ICEM), Oct. 21-26, 2001, Shizuoka, Japan. “Mutations Induced by Mutagens in Air and Water May Leave a Molecular Signature in Tumor Genes.” 64. Invited Participant in Workshop on Molecular Epidemiology at IARC in Lyon, France, November 14-17, 2001.

34 65. Invited Lecture at the International Course on Molecular Epidemiology, Torino, Italy, December 3-8, 2001, “From DNA Damage to Mutations.” 66. Invited Member, Steering Committee on “Defining the Mandate of Proteomics in the Post- Genomic Era,” National Academy of Sciences, February 25, 2002, Washington, DC. 67. Invited Speaker, American Chemical Society Short Course in Toxicology, Boston, MA, August 9, 2002. 68. Invited Speaker, International Society of Exposure Assessment and International Environmental Epidemiology Society conference, Vancouver, British Colombia, Canada. August 12-15, 2002. 69. Invited Lecturer in “Diet and Cancer” course at UNC, Dept. of Epidemiology, September 23, 2002. 70. Invited Lecturer, American Chemical Society Short Course in Toxicology, Ely Lilly Pharmaceutical Company, Indianapolis, IN, October 2, 2002. 71. Invited Lecturer, 34th Annual Meeting of the Environmental Mutagen Society, Miami Beach, FL, May 10-14, 2003, “Mutations Induced by Urban Air and Drinking Water: Do They Leave a Mutational Signature in Human Tumors?” 72. Invited Lecturer, Workshop on Health Effects of Chlorination Disinfection By-Products, Karlsruhe, Germany, September 2003. 73. Invited Lecture, “Mutagens in Air and Water,” Program in Toxicology, UC-Riverside, CA, Oct. 22, 2003. 74. Invited Lecture, Genotoxicity and Immunotoxicity Effects in Aquatic Systems, Koblenz, Germany, 22-24 April 2004. 75. Invited Lecture, “Bioassay-Directed Fractionation of Urban Air,” Association of Analytical Chemists (AOAC) International, September 23, 2004, St. Louis, MO. 76. Invited Lecture, Environmental Causes of Bladder Cancer, Barcelona, Spain, 12 Nov. 2004. 77. Invited Lecture, “Mutations Induced by Air and Water,” New York University, March 30, 2005. 78. Invited Lecture, “Mutations Induced by Air and Water,” Biochemistry Dept., North Carolina State University, April 7, 2005. 79. Invited Lecture, “Urinary Mutagenicity and Risk for Colon Cancer from Fried Meat

35 Consumption,” Georgetown University, April 15, 2005. 80. Invited Lecture, “Urinary Mutagenicity and Risk for Colon Cancer from Fried Meat Consumption,” NIEHS, RTP, NC, April 25, 2005. 81. Invited Lecture, “Mutations Induced by Air and Water,” 2nd International Symposium on Recent Advances in Environmental Health Research, September Jackson State University, Jackson, MS, September 18-21, 2005. 82. Invited Lecture, “Mutagenicity and Mutation Spectra of Air Pollutants,” Mechanisms of Air Pollution Toxicity Symposium, Riverside, CA, October 28-29, 2005. 83. Keynote Speaker, “Mutagenicity of Drinking Water” at the 11th Annual Meeting of the Chinese Environmental Mutagen Society, Chongqing, China, November 1-7, 2005. 84. Keynote Speaker, “Mutagenicity of Air and Water” at the 5th Meeting of the Pan-African Environmental Mutagen Society, Fes, Morocco, November 26-29, 2005. 85. Invited Lecture, “Urinary Mutagenicity and Risk for Colorectal Adenoma: Role of Dietary Antimutagens,” U.S. National Cancer Institute/NIH, Bethesda, MD, Feb. 9, 2006. 86. Keynote Speaker, 36th European Environmental Mutagen Society meeting, Prague, Czech Republic, July 2-6, 2006. “New Insights from an Old Assay: The Salmonella Assay Revisited.” 87. Invited Lecture, University of Vienna, Austria, July 7, 2006. “Diet, Antimutagens, and Cancer: A Human Study.” 88. Keynote Speaker, Annual Meeting of the Genetic Toxicology Association, “New Insights from the Salmonella Assay,” October 19, 2006, Newark, DE. 89. Invited Lectures, Alexander Hollaender Course on Genetic Toxicology, “Mutagenesis,” and “Mutagenicity of Urban Air,” October 23-27, 2006, Concepcion, Chile. 90. Invited Public Lecture, Nath Family Endowed Lecture, “Cancer: The Roles of Pollution, Diet, and Genes,” October 31, 2006, University of West Virginia, Morgantown, WV. 91. Invited Lecture, Mutagenicity and Mutation Spectra of Air and Water: Role of GSTT1-1 and AKR Genotypes, February 21, 2007, Health Canada, Ottawa, Canada. 92. Invited Speaker, Toxicology and Risk Assessment Conference, “Urinary Mutagenicity: A Biomarker of Genotoxic Exposure via Air, Water, and Diet,” April 25, 2007, Cincinnati, OH. 93. Invited Speaker, 5th International Conference on Environmental Mutagens in Human

36 Populations, “Urinary Mutagenicity as a Biomarker of Exposures Via Air, Water, and Diet,” Antalya, Turkey, May 20-24, 2007. 94. Plenary Speaker, 7th Congress of the Latin American Association of Mutagenesis, Carcinogenesis, and Teratogenesis, “Mutagenicity of Air and Water,” August 28-31, 2007, Cartagena, Colombia. 95. Invited Speaker, WaterCAMPWS Center, University of Illinois, Urbana, IL, Sept. 6, 2007. 96. Invited Speaker, 4th International Symposium on Recent Advances in Environmental Health Research, “Drinking Water and Cancer: A New View,” September 16-19, 2007, Jackson, MS. 97. Invited Speaker, 8th Congress of the Brazilian Society of Environmental Mutagenesis, Carcinogenesis, and Teratogenesis, “Mutagens in the Air and Water: Molecular Mechanisms,” October 28-31, 2007, Rio de Janeiro, Brazil. 98. Invited Speaker, 36th Annual meeting of the Japanese Environmental Mutagen Society, Kitakyushu, Japan, 29-30, November, 2007, “”Mutagenicity of Air and Water: Need for International Collaboration” 99. Invited Speaker, 9th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis, Jeju Island, South Korea, December 1-5, 2007, “”Inhibition of Fried Meat-Induced DNA Damage: Use of Cruciferous Vegetables, Yogurt, and Chlorophyllin in a Dietary Intervention Study in Humans.” 100. Invited Speaker, Symposium on Genetic, Pharmacologic and Nutritional Modulation of Carcinogenesis, Seoul, Korea, December 6, 2007, “Molecular Mechanisms of Antimutagenesis by Vanillin and Cinnamaldehyde in Bacteria and Human Cells.” 101. Invited Speaker, Department of Chemical Biology, Rutgers University, Piscataway, NJ, February 28, 2008, “Mutagenicity of Air and Water” Mechanisms and Biomakers.” 102. Invited Speaker, Workshop on in Silico Methods for Carcinogenicity and Mutagenicity, Milan, Italy, April 2-4, 2008, “Emerging Issues in Genotoxicity and Carcinogenicity: Implications for Structure-Activity Analyses.” 103. Invited Speaker, 2nd International Symposium on Genotoxicity in Aquatic Systems: Causes, Effects, and Regulatory Needs, Dessau-Roblau, Germany, April 14-16, 2008, “Mutagenicity and Mutation Spectra of Disinfection By-products of Drinking Water.” 104. Invited Speaker, Dept. of Chemistry, Jackson State University, Jackson, MS, May 1, 2008, “Fried Meat and Colon Cancer: Reduction in DNA Damage by Dietary Antimutagens in Humans.”

37 105. Invited Speaker, Symposium on Emerging Issues in Genotoxicity, Kuala Lumpur, Malaysia, June 15-22, 2008, “Overview of Mutagenesis,” “The Ames Assay,” “Genotoxicity Biomarkers.” 106. Invited Keynote Speaker, Genetic Toxicology Association, Newark, DE, September 10-11, 2008, “Biomarkers of Environmental Exposure to Genotoxicants.” 107. Invited speaker and symposium organizer, 39th Annual Meeting of the Environmental Mutagen Society Meeting, Rio Grande, Puerto Rico, October 17-23, 2008, “Genotoxicity of Disinfection By-products.” 108. Invited speaker, 6th Pan-African Environmental Mutagen Society meeting, Cape Town, South Africa, November 1-8, 2008, “Genotoxicity of Drinking Water.” 109. Invited speaker, 14th Alexander Hollaender Genetic Toxicology Course, Kolkata, India, December 7-13, 2008, Genotoxicity of Disinfection By-products.” 110. Invited speaker, German Environmental Protection Agency Conference on Swimming Pool Water, March 2-7, 2009, Dessau, Germany, “Genotoxicity of Disinfection By-products.” 111. Invited speaker, Dartmouth Medical School, Lebanon, NH, April 15, 2009, “Inhibition of Fried-Meat-Induced Colorectal DNA Damage and Altered Systemic Genotoxicity by Cruciferous Vegetables, Yogurt, and Chlorophyllin.” 112. Invited speaker, Gordon Conference on Drinking Water, August 9-14, 2009, Mount Holyoke College, South Hadley, MA, “Genotoxicity and Carcinogenicity of Drinking Water Disinfection By-products.” 113. Invited speaker, 10th International Conference on Environmental Mutagens, August 19-26, 2009, Florence, Italy, “Genotoxicity and Carcinogenicity of Disinfection By-products in Drinking Water.” 114. Invited speaker, Slovenian Congress of Biochemical and Genetic Societies, September 20- 23, 2009, Ljubljana, Slovenia, “Tandem Repeats to Detect Germ-Cell Mutations in Mice.” 115. Invited speaker, 30th Meeting of the International Union of Biological Sciences, Sun City, South Africa, 12-12 October, 2009, “Threshold Responses in Carcinogenesis.” 116. Invited Plenary Lecture, 40th Meeting of the Environmental Mutagen Society, St. Louis, MO, October 24-28, 2009, “EMS and Government Scientists: A Symbiosis” 117. Invited Lecture, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR, May 4-5, 2010, “Induction of DNA Damage in the Colon in Humans by Dietary Carcinogens and the Inhibition of the Damage by Dietary Anti-carcinogens.”

38 118. Invited Lecture, Dept. of Cell Biology and Neuroscience, University of California at Riverside, May 25-26, 2010; “Low-Dose Carcinogenicity Studies” and “Overview of Mutagenesis and Carcinogenesis Mechanisms” 119. Co-Chair and Plenary Speaker, 2nd Westlake Conference—Translational Medicine, June 24-26, 2010 in Hangzhou, China. “Biomarkers of Mutagen and Carcinogen Exposure in Humans” 120. Invited Lectures, University Kebangsaan, Kuala Lumpur, Malaysia, “Mutagenicity and Carcinogenicity of Drinking Water Disinfection by-products” and “Overview of Regulatory Genetic Toxicology,” June 27-29, 2010. 121. Invited Plenary Speaker, 10th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis, 26-29 September, 2010, Guaruja, Brazil. “Human Exposure to Environmental Mutagens and Antimutagens and Response of Genotoxicity Biomarkers.” 122. Invited Lecture, 2nd Asian Conference on Environmental Mutagens, Pattaya, Thailand, December 15-18, 2010. “Swimming and Drinking Water: Mutagenicity and Carcinogenicity. 123. Invited Lecture, Brazilian Society of Toxicology, June 18-26, 2011, Ribeiro Preto, Brazil, “Genotoxicity of Drinking Water and Swimming Pool Water” and 3 days of teaching on how to write a scientific paper (2 days in Limera, Brazil at the University of Campinus). 124. Invited Keynote Lecture, Italian Environmental Mutagen Society (SIMA), Parma, Italy, September 28-30, 2011; “40 Years of the Salmonella Mutagenicity Assay: What It Has to Tell Us Regarding 21st Century Toxicology” 125. Invited Lecture, UNC-Chapel Hill Science Café, Top of the Hill, Chapel Hill, NC, May 17, 2011; “Chlorinated Chromosomes: Swimming and Your Genes” 126. Invited Lecture, Biology Department, University of Pisa, Italy, September 28, 2011; “Carcinogenicity and Mutagenicity of Drinking Water” 127. Invited Lecture, University of Regina, Saskatchewan, Canada, October 7, 2011; “Carcinogenicity and Mutagenicity of Drinking Water” 128. Invited Lecture, School of the Environment, Duke University, Durham, NC, November 11, 2011; “Chlorinated Chromosomes: Swimming and Your Genes” 129. Invited Lecture as adjunct professor at the Univ. of North Carolina at Chapel Hill; 6th International Conference on Environmental Mutagens in Human Populations, 26-29 March 2012, Doha, Qatar. “Overview of Low-Dose Carcinogenicity Studies.” 130. Invited Lecture, IARC Workshop on Tumour Concordance and Mechanisms of Carcinogenesis, 16-18 April, 2012, Lyon, France. “Overview of the Hallmarks of Cancer.”

39 131. Invited Lecture, 3rd Asian Association of Environmental Mutagen Societies meeting, 23-26 October 2012; Hangzhou, China. “Comparative Mutagenicity of Diesel and Biodiesel Emissions.” 132. Invited Lectures, 11th International Conference on Environmental Mutagens in Iguazu Falls, Brazil; and Alexander Hollaender Course, Asuncion, Paraguay; November 1-13, 2013. Lectures on “Mechanisms of Mutagenesis” and “Genotoxicity of Biodiesel Emissions.” 133. Presented results of study of environment of the Penobscot Indian Nation to the Tribal Council, January 8, 2014, Penobscot Indian Nation, Maine. 134. Invited member of the IARC Monographs Advisory Group, April 2014, Lyon, France. 135. Invited speaker, American Association for Cancer Research Frontiers in Cancer Prevention Research meeting, Sept 28 to Oct 1, 2014, New Orleans, LA. How Air Pollution Causes Cancer. 136. Delivered eulogy at memorial service for Dr. Joellen Lewtas, Seattle, Sept 24, 2014. 137. Invited speaker at 54th annual meeting of SOT, symposium on IARC evaluation of outdoor air as a human carcinogen, San Diego, CA, March 2015; “Geenotoxicity and Epigenetics of Polluted Air in Humans.” 138. Invited Keynote Speaker at annual spring workshop of the Interdisciplinary Toxicology Program, University of Georgia, Athens, GA, April 15, 2015. “Cooking with Fire: Cookstove Health Safety as Revealed by Multidisciplinary Research.” 139. Invited Plenary Speaker at 38th annual meeting of the UK EMS, Plymouth, England, July 2015. “Cooking with Fire: Mutagenicity and Chemical Analysis of Cookstove Emissions.” 140. Invited speaker, 4th International Sympoisum on “Effects-Related Evaluation of Anthropogenic Trace Substances—Concepts for Genotoxicity, Neurotoxicity and Endocrine Effects.” Aachen, Germany, 21-22 October 2015, “Role of Human Inputs into the Mutagenicity and Chemical Composition of Swimming Pools and Hot Tubs (Spas)” 141. Invited speaker, 9th Congress of Toxicology in Developing Countries and 19th Brazilian Congress of Toxicology, 7-10 November, 2015, Natal, Brazil, “Recognition of Germ-Cell Mutagens and Future Directions.” 142. Invited speaker, 19th Alexander Hollaender Course, La Paz, Bolivia, November 17-21, 2015. “Mutagenesis,” “Carcinogenesis,” “How to Write a Scientific Paper.” CONSULTING ACTIVITIES

40 1. Taught the lectures titled “Mutagenesis” and “Carcinogenesis” for the Toxicology Short-Course sponsored by the American Chemical Society twice a year (May in San Francisco, October in Philadelphia) from 1998 to 2008. SERVICE ACTIVITIES 1. Co-founded 2 theater companies 1980-1982. Knoxville Children’s Theater (Knoxville, TN) and The Pellissippi Players (Oak Ridge, TN). 2. Volunteer, North Carolina Museum of Life and Science, Durham, NC. 3. Judge for North Carolina Regional Science Fairs, 1986-1993. 4. Taught 4th Grade at Eno Valley School, Durham, NC, throughout 1985-1986 as part of the Scientists in the Classroom Program sponsored by the North Carolina Museum of Life and Science, Durham, NC. 5. Taught gifted high school students at Millbrook High School, Raleigh, NC, sponsored by the Wake County Schools, 1986. 6. Taught part of the genetic toxicology portion of the graduate Toxicology Overview course at North Carolina State University, 1985 and 1986. 7. Treasurer and Member of the Board of Directors, Orange County Association for Retarded Citizens (ARC), Chapel Hill, NC, 1984-1987. 8. Taught high school teachers as part of the EPA Institute at the U.S. EPA, RTP, NC, August, 1990; August, 1994. 9. Taught science to a 4th grade class at Ephesus Elementary School, Chapel Hill, NC, 1992-1993. 10. Taught genetics to 8th grade class at Durham Academy, Durham, NC, 1997. 11. Taught mutagenesis and microbiology to 4th grade class at Brentwood Elementary School, Raleigh, NC, May 25, 1999 and many other schools in Raleigh, Cary, Durham, and Chapel Hill, NC through 2006. 11. Teach a variety of lectures in Molecular Epidemiology, Nutrition and Cancer, and Air Pollution at the School of Public Health, UNC, Chapel Hill, NC; 1990-present. 12. Teach in the US EPA/Shaw University Research Apprenticeship Program for Culturally Diverse High School Students (1999-present).

41 13. Volunteer to feed the homeless, Inter-faith Council, Chapel Hill, NC, 2006-present. 14. Member, American Civil Liberties Union (ACLU), 2006-present. 15. Member, Environment North Carolina, 2005-2007. 16. Taught 8th Grade mutagenesis at West Cary Middle School, Cary, NC, Oct. 2005, Spring and Fall of 2006. 17. Taught at Shaw University Mentoring Program for High School Students, February, 2007. 18. Lectures on Water Mutagenicity at UNC Science Café, May 2011, Chapel Hill, NC. 19. Taught 3 classes on environmental mutagenesis at Chatham Central High School, Bear Creek, NC, October, 2012. 20. Gave lecture on Genomic Biomarkers for course called “Biomarkers” at UNC in the Epidemiology Dept., November 2012. 21. Gave lecture on low-dose carcinogenicity for “Risk Assessment” course at UNC in the Dept. of Environ. Sci. Eng. in November 2012. 22. Give annual lectures on Mutagenesis and Carcinogenesis in Toxicology course in the Pharmacology Dept. at Duke University, Durham, NC, November 2002-2014. 23. Taught high school science classes at Community School of Davison, Davison, NC, February 10, 2014. 24. Directed a session of the UNC Student Science Policy Association, November 5, 2014. 25. Teach in course at Duke titled Mechanisms in Environmental Toxicology, March 2, 2015 on the mutagenicity and health risks associated with cookstove emissions. 26. Taught at Alternative Careers Symposium at UNC-Chapel Hill, April 30, 2015, and presented and outreach lecture to Meredith College students on May 11, 2015. 27. Serve as Secretary of the UNC-Chapel Hill Chapter of Sigma Xi, 2013-2016 and help conduct the Carolina Science Café, which is held monthly at Top of the Hill Bar in Chapel Hill, NC.