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_________________________________ Overtoom Medical Solutions a division of Overtoom Ltd., Dublin Ireland Vat number: IE 8293967H Company Registration: No. 293967 (Ireland)

HLB Nathans, 3rd Floor Ulysses House, Foley Street Dublin 1, Ireland

[email protected]

The maxim of minimum mutilation

T.Th.C. Overtoom MD April 2011

Curriculum vitae

Person: surname : Overtoom

first names : Timotheus Theodorus Cornelis born : 14 - 11 - ‘46 in Berkhout Netherlands Interventional radiologist

Radio vascular department St. Antonius hospital

Koekoekslaan 1 3435CM NIEUWEGEIN The Netherlands

tel. 0031 30 6099111 Fax: 030 6092999 e-mail: [email protected]

[email protected] This hospital is located in the middle of Holland. It’s a thorax, vascular and lung centre and up to 2000 hearth operations per year are done. It has experiences with single and double- sided lung transplantations. Percutaneous heart valves implantations. Endografting.

Education: - 6 years HBS-B (secondary school) Petrus Canisius College Alkmaar - University of Amsterdam:

3 years philosophy Prof. Barendse 1 year musicology Prof. Noske

- 2 years conservatory - 1973 start medical studies Univ. of Amsterdam - 1978 doctoral degree - 1981 MD

mailto:[email protected]




_________________________________ Overtoom Medical Solutions a division of Overtoom Ltd., Dublin Ireland

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- since 1981 resident radiology trained by Dr.W.Ludwig in the St.Antonius hospital. We started to develop digital angiographic technics with the application engineers of Philips (first digital angio equipment in Europe) under the supervision of Dr.Ludwig.

- Personal experience with more than 4000 intravenous angiographic patient studies (more than 16000 i.v. contrast injections).

- 1982 Start regular training in all aspects of radiology. Since 1986 registered radiologist.

- January 1987 radiologist in the St. Laurentius hospital in Roermond . - In 1988 asked to come back to my training hospital to take over the

position of Dr. Ludwig because of his retirement as an intervention radiologist where I started in Jan. 1989.

- special training/courses for neurointerventions: o Valavanis Zurich (two courses) o University of Oxford for training coiling brain aneurysms

Experience: Interventional radiology since 1985 as main interest. All angiographical fields: arterially: super selective: - external/internal carotid artery

- vertebral, spinal - peripherals, lungs, pulmonary/bronchial arteries - visceral

venous: phlebography: - legs, arms, epidural, spermatic/ovarical veins Interventional technics :

- PTA’s of: - arch arteries - carotid arteries (extra cranial and intracranial)

- vertebral arteries - basilary artery - renal - abdominal aorta, iliac, femoral, crural - fem.pop. bypasses - shunts for dialysis



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- Recanalisations of: - subclavian arteries - renal, iliac, femoral, crural arteries and abdominal aorta.

- internal carotid arteries

- Several types of stents placed: - intracaranial micro-stenting M1,M2, bas.art. - aorto coronary bypasses

- subclavian art., renal art., coeliac trunc - mesenteric art., abdominal aorta, liac art.,

- shunts for dialyses - superior caval vein - covered stents in: craniopetal vessels other peripheral arteries

- Selective thrombolysis: - intra arterial STROKE treatment in MCA and basilar

arteries - peripheral art.

- bypasses - central retinal artery in case of acute blindness

- intra cranial venous thrombosis

- Embolisation technics: - Coils, plugs, covered plugs, particles, glue,

detachable balloons - AV malformations pulmonary arteries

o embolisation of: - internal carotid artery for inoperable aneurysms - dural fistulas - epistaxis - AV fistulas and haemangiomas in external carotid

art. - bronchial arteries

- coronary-pulmonary fistulas



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- coronary AV fistulas in Left and Right coronary arteries

- hepatic arteries - insulinomas - false aneurysms splenic art., visceral - skeletal metastases - AVM 's pulmonary arteries

simple and complex malformation (Rendu-Osler-Weber)

- false aneurysms and AV fistulas in the groin - AVM’s peripheral arteries - spermatic/ovarical veins - oesophageal bleedings - bowel bleedings - kidney and bladder bleedings - gynecological bleedings - cavernous haemangiomas

- Ultrasound guided interventions : - internal drainage of pancreatic cysts to the

stomach with double pigtails - nephrostomies of nondilated pelvic systems for

choral stone removal - biliary drainage (internal/external) - abscess drainages - cytologic/histologic biopsies

- CT guided punctures and other interventions

- f.i. vertebroplasty Special procedures:

- intra arterial stroke treatment: intracranial throbolysis, thrombectomies

aspiration. First procedure in Europe in 2004 (with Merci device). and micro-stent placement.

- reconstruction of occluded inferior caval veins (including occl. of iliac veins) - PTA of trachea web stenosis of anastomosis transplanted lung



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- aspiration embolectomy of pulmonary arteries - stenting ureters (in patients with Bricker bladders) - retrieving catheter fragments from pulmonary arteries and epidural

space - implantation of stentfixed PTFE endoprosthesis after ringstrip

endarterectomie in the superficial femoral artery from a groin insicion (with the vascular surgeon) from femoral bifurcation to the popliteal artery.

- aorto bifurcation stentgrafts, fenestrated endografts - thoracic stentgrafts - stentgrafts in periferal arteries - recanalisations of lowerleg arteries from ankle stream up

Publications can be found on Pubmed with the name:

- T.Th.C. Overtoom - or T.T.C. Overtoom

Lectures and courses given only mentioned on special request.

Member of:

- NVvR - NGIR - ARRS - International Society of Endovascular Specialists - De Orde



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Timotheus T Th C Overtoom, [degree] https://www.researchgate.net/profile/Timotheus_Overtoom/

Statistics

RG Score –

Publications 55

Total Impact Points 152.6

Views 14

Downloads 5

Citations 355

Skills & Activities

Skills Endovascular Surgery, Interventional Neuroradiology, Vascular Imaging, Aneurysm, Infected Aneurysm, Balloon Angioplasty, Abdominal Aorta, Aortic Coarctation, Aortic Diseases, Arteries, Arteriovenous Fistula, Carotid Arteries, Carotid Artery Diseases, Intracranial Aneurysm, Intracranial Arteriovenous Malformations, Mesenteric Vascular Occlusion, Vascular Diseases, Vasodilation, Peripheral Vascular Diseases, Carotid Stenosis, Angioplasty, Carotid Artery Injuries, Dissection Carotid Artery, Atherosclerosis, Endovascular Procedures, Endoleak, Peripheral Arterial Disease, Abdominal Aortic Aneurysm, Deep Vein Thrombosis, Atherosclerotic Vascular Diseases, UPJ obstructions, ureteral strictures, ureteral stenosis

Languages

Scientific Memberships

Interests

https://www.researchgate.net/profile/timotheus_overtoom/



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Journal Publications Sicco J Braak, Kirsten Zuurmond, Hans C J Aerts, Marc van Leersum,

Timotheus T Th Overtoom, Johannes P M van Heesewijk, Marco J L

van Strijen: Feasibility Study of Needle Placement in Percutaneous

Vertebroplasty: Cone-Beam Computed Tomography Guidance Versus

Conventional Fluoroscopy.. CardioVascular and Interventional

Radiology 03/2013;

N Habib, A Jerzewski, E M Koomen, B E Groenemeijer, R A Waalewijn, R L

Braam, W Ten Hove, T T C Overtoom: Subclavian artery perforation

complicating coronary angiography.. Netherlands heart journal: monthly

journal of the Netherlands Society of Cardiology and the Netherlands

Heart Foundation 05/2011; 20(6):288-90.

Cornelis J J Westermann, Johannes J Mager, Henk W Mauser, Tim T C

Overtoom: Stroke following pulmonary arteriovenous fistula embolization

in a patient with HHT.. Neurology 10/2009; 73(17):1427; author reply

1427.

Jan Albert Vos, Gert Jan de Borst, Tim T Overtoom, Jean Paul P de Vries,

Eric D van de Pavoordt, Pieter Zanen, Rob G Ackerstaff: Carotid

angioplasty and stenting: treatment of postcarotid endarterectomy restenosis

is at least as safe as primary stenosis treatment.. Journal of vascular

surgery: official publication, the Society for Vascular Surgery [and]

International Society for Cardiovascular Surgery, North American

Chapter 08/2009; 50(4):755-761.e1.

S J Braak, C A de Witt, F J M Disch, T Th C Overtoom, J J Westermann:

Percutaneous embolization on hereditary hemorrhagic telangiectasia patients

with severe epistaxis.. Rhinology 07/2009; 47(2):166-71.

Timotheus T C Overtoom, Peter L Vijverberg, Hendrik W van Es, Sandrine

van Selm, Hans P M van Heesewijk: Treatment of ureteropelvic junction

obstruction using a detachable inflatable stent: initial experience.. American

Journal of Roentgenology 05/2009; 192(4):1103-6.



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M C Post, M W F van Gent, H W M Plokker, C J J Westermann, J C Kelder,

J J Mager, T T Overtoom, W J Schonewille, V Thijs, R J Snijder:

Pulmonary arteriovenous malformations associated with migraine with

aura.. European Respiratory Journal 04/2009; 34(4):882-7.

Marco W F van Gent, Martijn C Post, Repke J Snijder, Martin J Swaans,

Herbert W M Plokker, Cornelis J J Westermann, Tim T Overtoom,

Johannes J Mager: Grading of pulmonary right-to-left shunt with

transthoracic contrast echocardiography: does it predict the indication for

embolotherapy?. Chest 01/2009; 135(5):1288-92.

M W F van Gent, M C Post, J G L M Luermans, R J Snijder, C J J

Westermann, H W M Plokker, T T Overtoom, J J Mager: Screening for

pulmonary arteriovenous malformations using transthoracic contrast

echocardiography: a prospective study.. European Respiratory Journal

10/2008; 33(1):85-91.

J Mathijs Vogten, Tim T C Overtoom, Rutger J Lely, Rutger Quispel, Jean

Paul P M de Vries: Superselective coil embolization of arterial esophageal

hemorrhage.. Journal of Vascular and Interventional Radiology

07/2007; 18(6):771-3.

G.J. de Borst, R G Ackerstaff, J.P.P.M. de Vries, E.D. van de Pavoordt, J A

Vos, T T Overtoom, F.L. Moll: Carotid angioplasty and stenting for

postendarterectomy stenosis: long-term follow-up.. Journal of Vascular

Surgery 02/2007;

E D Ponfoort, H D W M de van Pavoordt, T Th C Overtoom, R M The, J P P

M de Vries: [Four patients with aneurysm of the hepatic artery]..

Nederlands tijdschrift voor geneeskunde 06/2006; 150(25):1402-6.

Jan Wille, Jan Albert Vos, Tim T C Overtoom, Maarten J Suttorp, Eric D W

M van de Pavoordt, Jean-Paul P M de Vries: Acute leg ischemia: the dark

side of a percutaneous femoral artery closure device.. Annals of Vascular

Surgery 04/2006; 20(2):278-81.



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Willemijn M Klein, Yolanda van der Graaf, Jan Seegers, Johannes H

Spithoven, Erik Buskens, Jeff G van Baal, Jaap Buth, Frans L Moll, Tim

T C Overtoom, Marc R H M van Sambeek, Willem P T M Mali: Dutch

iliac stent trial: long-term results in patients randomized for primary or

selective stent placement.. Radiology 03/2006; 238(2):734-44.

W.M. Klein, Y. van der Graaf, J. Seegers, J.H. Spithoven, E. Buskens, J.G.

van Baal, J Buth, F.L. Moll, T T Overtoom, M R H M van Sambeek,

W.P.T.M. Mali: Dutch iliac stent trial: long-term results in patients

randomized for primary or selective stent placement.. 01/2006;

Jan Albert Vos, A W Floris Vos, Matteus A M Linsen, J Tim Marcus,

Timotheus Th C Overtoom, Jos C van den Berg, Willem Wisselink:

Impact of head movements on morphology and flow in the internal carotid

artery after carotid angioplasty and stenting versus endarterectomy.. Journal

of Vascular Surgery 04/2005; 41(3):469-75.

Jan Albert Vos, Jos C van den Berg, Sjef M P G Ernst, Maarten Jan Suttorp,

Timotheus T C Overtoom, Henk W Mauser, Oscar J M Vogels, Hans P

M van Heesewijk, Frans L Moll, Yolanda van der Graaf, Willem P T

Mali, Rob G A Ackerstaff: Carotid angioplasty and stent placement:

comparison of transcranial Doppler US data and clinical outcome with and

without filtering cerebral protection devices in 509 patients.. Radiology

03/2005; 234(2):493-9.

J A W Teijink, J A van Herwaarden, J C van den Berg, T C Overtoom, F L

Moll: Airport and superficial femoral artery obstruction due to a wandering

coronary stent: the possibility of airport detection of modern implant metals..

The Journal of cardiovascular surgery 07/2004; 45(3):279-80.

J J Mager, T T Overtoom, H. Blauw, J.W.J. Lammers, C J J Westermann:

Embolotherapy of pulmonary arteriovenous malformations: long-term results

in 112 patients.. Journal of Vascular and Interventional Radiology

06/2004;



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M H Christiaans, J M P G Ernst, M J Suttorp, J C van den Berg, T Th C

Overtoom, J C Kelder, H W Mauser, R G A Ackerstaff: Restenosis after

carotid angioplasty and stenting: a follow-up study with duplex

ultrasonography.. European Journal of Vascular and Endovascular

Surgery 08/2003; 26(2):141-4.

M. H. Christiaans, J. M. P. G. Ernst, M. J. Suttorp, J. C. van den Berg, T. Th.

C. Overtoom, J. C. Kelder, H. W. Mauser, R. G. A. Ackerstaff:

WITHDRAWN: Restenosis after Carotid Angioplasty and Stenting: a

Follow-up Study with Duplex Ultrasonography. European Journal of

Vascular and Endovascular Surgery - EUR J VASC ENDOVASC

SURG. 01/2003;

Hans P M van Heesewijk, Jan Albert Vos, Elisabeth S Louwerse, Jos C Van

Den Berg, Timotheus T C Overtoom, Sjef M P G Ernst, Henk W

Mauser, Frans L Moll, Rob G A Ackerstaff: New brain lesions at MR

imaging after carotid angioplasty and stent placement.. Radiology 09/2002;

224(2):361-5.

J C van den Berg, T Th C Overtoom, J C de Valois, F L Moll: Using three-

dimensional rotational angiography for sizing of covered stents.. American

Journal of Roentgenology 02/2002; 178(1):149-52.

R H Heijmen, J A Teijink, J C van den Berg, T T Overtoom, G Pasterkamp, F

L Moll: Use of a balloon-expandable, radially reinforced ePTFE endograft

after remote SFA endarterectomy: a single-center experience.. Journal of

Endovascular Therapy 08/2001; 8(4):408-16.

R H Heijmen, T L Bollen, D A Duyndam, T T Overtoom, J C Van Den Berg,

F L Moll: Endovascular venous stenting in May-Thurner syndrome.. The

Journal of cardiovascular surgery 03/2001; 42(1):83-7.

H J Mager, T T Overtoom, H W Mauser, K J Westermann: Early cerebral

infarction after embolotherapy of a pulmonary arteriovenous malformation..

Journal of Vascular and Interventional Radiology 02/2001; 12(1):122-3.



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R H Heijmen, R P Tutein Nolthenius, J C van den Berg, T T Overtoom, F L

Moll: A narrow-waisted abdominal aortic aneurysm complicating

endovascular repair.. Journal of Endovascular Therapy 07/2000;

7(3):198-202.

R B Willemse, J J Mager, C J Westermann, T T Overtoom, H Mauser, J G

Wolbers: Bleeding risk of cerebrovascular malformations in hereditary

hemorrhagic telangiectasia.. Journal of Neurosurgery 06/2000; 92(5):779-

84.

G H Ho, F L Moll, R P Tutein Nolthenius, J C van den Berg, T T Overtoom:

Endovascular femoropopliteal bypass combined with remote endarterectomy

in SFA occlusive disease: initial experience.. European Journal of Vascular

and Endovascular Surgery 02/2000; 19(1):27-34.

T J Haitjema, R van Snippenburg, F J Disch, T T Overtoom, C J

Westermann: [Recurrent epistaxis: sometimes Rendu-Osler-Weber

disease].. Nederlands tijdschrift voor geneeskunde 12/1996;

140(44):2157-60.

P P Hedeman Joosten, G H Ho, F A Breuking, T T Overtoom, F L Moll:

Percutaneous transluminal angioplasty of the infrarenal aorta: initial

outcome and long-term clinical and angiographic results.. European

Journal of Vascular and Endovascular Surgery 09/1996; 12(2):201-6.

G H Ho, F L Moll, P P Hedeman Joosten, H D van de Pavoordt, J C van den

Berg, T T Overtoom: Endovascular remote endarterectomy in

femoropopliteal occlusive disease: one-year clinical experience with the ring

strip cutter device.. European Journal of Vascular and Endovascular

Surgery 08/1996; 12(1):105-12.

J C Van den Berg, T T Overtoom, J C De Valois: Case report: bronchial to

coronary artery anastomosis--a potential hazard in bronchial artery

embolization.. British Journal of Radiology 07/1996; 69(822):570-2.



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F L Moll, G H Ho, P P Joosten, H D van De Pavoordt, T T Overtoom:

Endovascular remote endarterectomy in femoropopliteal long segmental

occlusive disease. A new surgical technique illustrated and preliminary

results using a ring strip cutter device.. The Journal of cardiovascular

surgery 07/1996; 37(3 Suppl 1):39-40.

T Haitjema, J M ten Berg, T T Overtoom, J M Ernst, C J Westermann:

Unusual complications after embolization of a pulmonary arteriovenous

malformation.. Chest 06/1996; 109(5):1401-4.

T Haitjema, C J Westermann, T T Overtoom, R Timmer, F Disch, H Mauser,

J W Lammers: Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu

disease): new insights in pathogenesis, complications, and treatment..

Archives of Internal Medicine 05/1996; 156(7):714-9.

A M Spijkerboer, P C Nass, J C de Valois, B C Eikelboom, T T Overtoom, F J

Beek, F L Moll, W P Mali: Iliac artery stenoses after percutaneous

transluminal angioplasty: follow-up with duplex ultrasonography.. Journal

of Vascular Surgery 04/1996; 23(4):691-7.

J C Van Den Berg, T T. C Overtoom, J C D. Valois: Bronchial to coronary

artery anastomosis -- a potential hazard in bronchial artery embolization.

British Journal of Radiology - BRIT J RADIOL. 01/1996; 69(822):570-

572.

T Haitjema, F Disch, T T Overtoom, C J Westermann, J W Lammers:

Screening family members of patients with hereditary hemorrhagic

telangiectasia. The American Journal of Medicine 12/1995; 99(5):519-24.

S C Hiep-van Casteren, C J Westermann, R P Hamerlijnck, P H Cornelissen,

T T Overtoom: Aortobronchial fistula after correction of congenital

cardiovascular abnormalities.. European Respiratory Journal 11/1995;

8(10):1796-8.



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G H Ho, F L Moll, P P Joosten, E D van de Pavoordt, T T Overtoom: The

Mollring Cutter remote endarterectomy: preliminary experience with a new

endovascular technique for treatment of occlusive superficial femoral artery

disease.. Journal of Endovascular Surgery 09/1995; 2(3):278-87.

T J Haitjema, T T Overtoom, C J Westermann, J W Lammers: Embolisation of

pulmonary arteriovenous malformations: results and follow up in 32

patients.. Thorax 07/1995; 50(7):719-23.

W L Akkersdijk, J C de Valois, T T Overtoom, F L Moll: [Spontaneous

dissection of the iliac artery; treatment with a stent].. Nederlands

tijdschrift voor geneeskunde 09/1994; 138(32):1626-8.

J W ter Berg, T M Overtoom, J W Ludwig, J B Bijlsma, C A Tulleken, J

Willemse: Detection of unruptured familial intracranial aneurysms by

intravenous digital subtraction angiography. Screening of two affected

families.. Neuroradiology 02/1987; 29(3):272-6.

J. W. M. ter Berg, T. M. D. Overtoom, J. W. Ludwig, J. B. Bijlsma, C. A. F.

Tulleken, J. Willemse: Detection of unruptured familial intracranial

aneurysms by intravenous digital subtraction angiography.

Neuroradiology 01/1987; 29(3):272-276.

P H Elsenburg, T T Overtoom, B C Eikelboom, C A Tulleken:

Ophthalmopneumoplethysmography (OPG-Gee) without and with bypass-

compression for quantification of hemodynamic significance of superficial

temporal artery-middle cerebral artery (STA-MCA) anastomosis.. Clinical

Neurology and Neurosurgery 02/1985; 87(4):259-66.

A R de Vries, P H Engels, T T Overtoom, T P Saltzherr, B G Geyskes:

Interobserver variability in assessing renal artery stenosis by digital

subtraction angiography.. Diagnostic imaging in clinical medicine

02/1984; 53(6):277-81.

J W Ludwig, P H Engels, T T Overtoom: Application of digital vascular

imaging in interventional radiology.. Annales de radiologie 12/1983;

26(7):585-8.



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J W Ludwig, P Engels, T Overtoom: Digital vascular imaging in extra- and

intracranial artery disease and of abdominal arteries.. European Journal of

Radiology 09/1983; 3 Suppl 1:251-6.

J W Ludwig, L A Verhoeven, J J Kersbergen, T T Overtoom: Digital

subtraction angiography of the pulmonary arteries for the diagnosis of

pulmonary embolism.. Radiology 07/1983; 147(3):639-45.

R A Tange, T T Overtoom, J W Ludwig: A new angiographic technique for

asymptomatic hereditary glomus screening.. Archives of Oto-Rhino-

Laryngology 02/1983; 238(2):143-8.

R. A. Tange, T. T. C. Overtoom, J. W. Ludwig: Eine neue angiographische

Technik zur Darstellung asymptomatischer heredit�rer Glomustumoren.

European Archives of Oto-rhino-laryngology - EUR ARCH OTO-

RHINO-LARYNGOL. 01/1983; 238(2):143-148.

A R de Vries, J W Ludwig, P H Engels, T T Overtoom: Digital subtraction

angiography of the carotid bifurcation.. International angiology: a journal

of the International Union of Angiology 4(4):483-6.

Willemijn M. Klein, Yolanda van der Graaf, Jan Seegers, Johannes H.

Spithoven, Erik Buskens, Jeff G. van Baal, Jaap Buth, Frans L. Moll,

Tim T. C. Overtoom, Willem P. T. M. Mali, Iliac Stent Trial:

ResultsinPatientsRandomizedfor PrimaryorSelectiveStentPlacement1.

E.J. Waasdorp, J.A. van Herwaarden, H.M. Kelder, E.D. van de Pavoordt, T

T Overtoom, F.L. Moll, J.P.P.M. de Vries: Renal Function After

Endovascular Aortic Aneurysm Repair: A Single-center Experience with

Transrenal Versus Infrarenal Fixation.

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