curriculum vitae - corporate wellness resources · curriculum vitae name: robert a. levine, ph.d.,...

CURRICULUM VITAE

NAME: Robert A. Levine, Ph.D., C.Ht.

BIRTHDATE: July 25, 1954

BIRTHPLACE: Waltham, Massachusetts

MARITAL STATUS: Married to Charlene with 3 sons

RESIDENCE: 6070 Oak Trail

West Bloomfield, MI 48322

(248) 615-1010

(206) 666-2803 (Fax)

(248) 342-7555 (Cell)

OFFICE ADDRESS: Corporate Wellness Resources, LLC

16250 Northland Drive, Suite 160

Southfield, MI 4807

(248) 850-4297

(206) 666-2803 (FAX)

Email: [email protected] or [email protected]

http://www.CWRnow.com or

http://www.corporatewellnessresources.com

CURRENT POSITIONS: Vice President, Wellness and High-Performance Strategies

Corporate Wellness Resources, LLC

Southfield, MI

(see page 22 for summary of Integrative Medicine activities)

Clinical Professor of Wellness, Health Promotion, and

Injury Prevention

School of Health Sciences, Oakland University

Adjunct Professor of Pharmaceutical Sciences

Wayne State University

Robert A. Levine, Ph.D., C.Ht.

2

EDUCATION:

January 2002 - April 2002 Hypnotherapy Certification (C.Ht.)

Infinity Institute, Royal Oak, MI

Basic and advanced hypnosis, regression analysis, guided

imagery, holistic hypnoanalysis

September 2000 - May 2001 Medical Acupuncture for Physicians Program (Dr. Joe Helms)

UCLA School of Medicine, Los Angeles, CA

300 CME credits received

Fall 1996 - Spring 2001 Trained in St. John Neuromuscular Therapy (NMT); now

referred to as Neurosomatic Therapy

(www.neurosomaticeducators.com)

Attended the following seminars: NMT1, NMT2, NMT3,

NMT5, NMT6, NMT7 offered by the St. John Neuromuscular

Pain Relief Institute, Largo, FL

September 1977 - July 1982 George Washington University Major: Pharmacology

Washington, D.C. DEGREE: Ph.D.

Ph.D. coursework included taking the first 2 years of medical

school coursework with medical students (e.g. medical

biochemistry, physiology, pharmacology, pathology,

neuromuscular anatomy, etc.) before taking specialized

pharmacology classes, research electives, and conducting

graduate level teaching and thesis research.

September 1976 - May 1977 George Washington University Graduate level courses

Washington, D.C.

September 1972 - June 1976 University of Massachusetts Major: Zoology

Amherst, MA DEGREE: B.S.

PREDOCTORAL TRAINING:

September 1977 - June 1983 Pharmacologist research appointment

Section on Biochemical Pharmacology

National Heart, Lung, and Blood Institute, NIH

Bethesda, MD

June 1977 - August 1977 Summer research appointment

Section of Biochemical Pharmacology


Bethesda, MD (salary paid by University of Vermont)

http://www.neurosomaticeducators.com/


3

PREDOCTORAL TRAINING (continued):

June 1976 - May 1977 Part-time graduate student research appointment

Laboratory of Chemical Pharmacology


Bethesda, MD

June 1975 - August 1975 Summer research appointment

Laboratory of Chemical Pharmacology


Bethesda, MD

POSTDOCTORAL TRAINING:

July 1983 - August 1985 Visiting Scientist

Children’s Hospital of Zurich (intermittent collaborative

research trips; Professor Hans-Christoph Curtius, sponsor)

Zurich, Switzerland

July 1983 - August 1985 Pharmacology Research Associates Training Program Fellow

National Institute of General Medical Sciences, and

Laboratory of Cell Biology and Genetics, NIADDK, NIH

Bethesda, MD

July 1982 - June 1983 Postdoctoral fellow



Bethesda, MD

EMPLOYMENT:

July 2012 – present Vice President, Wellness and High-Performance Strategies

Corporate Wellness Resources, LLC

Southfield, MI

April 2008 – July 2012 Director, Center for Integrative Wellness

Director, Integrative Wellness Research

Henry Ford Health System

Detroit, MI

Sept. 2000 - December 2008 Co-director, Henry Ford Center for Integrative Medicine

Director, Integrative Medicine Research

Henry Ford Health System

Detroit, MI


4

EMPLOYMENT (continued):

January 1993 - March 2007 Director, William T. Gossett Neurology Laboratories

Henry Ford Health System, Detroit, MI

March 1992 – December 2006 Research Pharmacologist

Detroit Veterans Administration Medical Center

August 1985 - December 1992 Director, Laboratory of Molecular Neurobiology

Director, Clinical Chemistry Laboratory

Lafayette Clinic

Detroit, MI

ACADEMIC APPOINTMENTS:

September 2005 - Present Clinical Professor of Wellness, Health Promotion, and

Injury Prevention

School of Health Sciences, Oakland University

March 1997 - Present Adjunct Professor

Department of Pharmaceutical Sciences


Detroit, MI

December 2000 - 2002 Adjunct Professor of Energy Medicine

Greenwich University

Norfolk Island, Australia

January 1993 - March 1997 Adjunct Associate Professor

Department of Psychiatry and Behavioral Neurosciences


Detroit, MI

January 1988 - December 1992 Associate Professor



Detroit, MI

August 1985 - December 1987 Assistant Professor



Detroit, MI


5

PROFESSIONAL AFFILIATIONS:

International Medical and Dental Hypnotherapy Association

International Association of Counselors and Therapists

AWARDS AND HONORS:

2011 Detroit Crain’s Healthcare Heroes 2011

Dr. Levine was the recipient of the Corporate Achievement

Award for group programs offered to large self-funding

corporations to provide relief of chronic pain, stress, and

symptoms of stress-related conditions. Levine operates on the

principle that the main way of reducing national healthcare

costs in the long-run is to produce sustained health

improvement. The group programs have demonstrated

improved health that is sustained for up to 16 months after

programs end. See online:

http://www.crainsdetroit.com/article/20110911/AWARDS05/30

9119983/wellness-programs-go-on-the-road

2010 Henry Ford Health System Quality and Safety Expo

Competition Winner for “Stress and Pain Free Living”

programs offered at Chrysler & HFHS employees

Henry Ford Health System recognized the further innovations

brought to the group wellness programs offered by the Center

for Integrative Wellness. New for 2010 were programs offered

at Dow Chemical, Midland and the community program at New

Hope Missionary Baptist Church. The results of these

independent programs were equivalent and equal to the positive

outcomes produced in earlier years (see description below).

This project demonstrated that programs could be effective

when offered outside the Detroit Metro area (Midland) and

when delivered to an African American population in the faith-

based community.

2010 International Medical and Dental Hypnotherapy Association

Outstanding Research Award in the Mind-Body Medicine

Award Presented at the International Medical and Dental

Hypnotherapy Association annual international meeting.






http://www.crainsdetroit.com/article/20110911/AWARDS05/309119983/wellness-programs-go-on-the-road



6

AWARDS AND HONORS (continued):

for Integrative Wellness. New for 2009 was the tracking of

stress elimination in Chrysler and HFHS employees. Stress

elimination, defined as a score of 0 average stress in the last

week on a 0-10 scale (score of 0 is when more than 95% of the

time is spent free of unhealthy stress reactions), was reported by

14% of participants. Programs were reduced from 24 to 18

contact hours; elimination of chronic pain conditions was

sustained at 45%, and other validated measures were favorably

impacted (disability, stress, and depression were significantly

reduced; sleep quality was significantly improved).


One of eight awardees in the Southeast Michigan area. Dr.

Levine was the recipient of a Corporate Achievement Award for

the Chrysler “We’ve Got Your Back” program. Chrysler

employees were treated in the workplace in groups of up to 48

people at a time with a hands-off complementary and alternative

medicine approach. After 24 contact hours over 6 months, 55%

of reporting employees eliminated back pain compared with 0%

of untreated, randomized controls. There were also significant

reductions in stress, disability, and depression symptoms, as

well as improvements in sleep quality. See online:

http://www.crainsdetroit.com/article/20080810/AWARDS/8081

10320/-1

2008 HFHS Quality and Safety Expo Competition Winner for

Chrysler & HFHS Pain Alleviation Program

Henry Ford Health System recognized the quality of the group

pain alleviation programs offered by the Center for Integrative

Wellness. The programs offered under the umbrella of “Pain

Free in 2008” received the award for the positive health

outcomes achieved with employees of Chrysler (“Pain

Free Zone”) and HFHS (“Living a Pain Free Life”). All

musculoskeletal pain conditions were included in the same

group and employees received 24 contact hours over about 7

months; 35% of all chronic pain conditions were eliminated.

There were also significant reductions in stress, disability, and

depression symptoms, as well as improvements in sleep quality.

http://www.crainsdetroit.com/article/20080810/AWARDS/808110320/-1

http://www.crainsdetroit.com/article/20080810/AWARDS/808110320/-1


7


2007 Focus on People 2007 Award for Chrysler Back Pain Program

Presented by the Board of Trustees of Henry Ford Health

System to Dr. Levine and his team for creating and delivering

the “We’ve Got Your Back” program to Chrysler employees

(results described above).


Competition Winner for Chrysler Back Pain Program

Henry Ford Health System recognized the achievement in

enhancing quality for a major System employer group through

offering the “We’ve Got Your Back” program to Chrysler

employees (results described above).

2005 Focus on People 2005 Award


System for participation in the “Journey to Wellness” Program,

an educational and intervention program designed to support the

health and wellness of members of city of Detroit churches.

2004 Distinguished Researcher in Hypnotherapy Award Presented at the International Medical and Dental Hypnotherapy

Association annual international meeting.

2002 Deputy Director for National Center for Complementary and

Alternative Medicine at NIH- Interviewee

One of 3 individuals selected from several hundred applicants to

interview for the position of Deputy Director reporting to

Steven Straus, then the Director of NCCAM. Although not

selected, this was recognition of Dr. Levine’s broad expertise in

conventional basic and clinical research, experience and

productivity in NIH grant-funded research and peer-review

publications, being a practitioner of integrative medicine

therapies, and having expertise in integrative medicine basic

and clinical research.

June 1996 - May 1997 Exceptional Performance Award

Detroit VA Medical Center

June 1995 - May 1996 Outstanding Rating Certificate

Detroit VA Medical Center


8

FELLOWSHIPS:

July 1983 - August 1985 Pharmacology Research Associate Training Program

Fellowship

National Institutes of General Medical Sciences

National Institutes of Health

Bethesda, MD

July 1982 - July 1983 Postdoctoral fellowship



Bethesda, MD

March 1983 Outstanding Young Investigator in Neurochemistry

Awarded by Vector Labs, Inc.

July 1982 - September 1982 Roche Research Foundation (Basel) Senior Scientist Award

To support collaborative work in Department of Pediatrics

Children’s Hospital of Zurich, Switzerland

CONSULTING:

January 1988 - Dec 2000 Ronald L. Hofer of Harness, Dickey, and Pierce Patent Firm

Consulted on intellectual property and patents related to

biotechnology

October 1990 - June 1992 Suntory Limited, Pharmaceutical Division

Consultant on clinical trials with tetrahydrobiopterin therapy in

Alzheimer's disease, familial dystonia, and infantile autism

May 1980 - August 1984 Fund for Integrative Biomedical Research (FIBER).

Consulted for Scientific Director on scientific merit and

economic feasibility of proposals on neuropsychiatry and aging

JOURNAL/EDITORIAL ACTIVITY:

Books Edited: Pteridines and Related Biogenic Amines and Folates-1992. N. Blau, H.-Ch.

Curtius, R.A. Levine, and J. Yim (eds.), Hanrim Publishing Co., Seoul 100-

230, Korea, 1992

Pterins and Biogenic Amines in Neurology, Pediatrics, and Immunology. N.

Blau, H.-Ch. Curtius, R.A. Levine, and R.G.H. Cotton (eds.), Lakeshore

Publishing, MI, 1991


9

JOURNAL/EDITORIAL ACTIVITY (continued):

Pteridines and Biogenic Amines in Neuropsychiatry, Pediatrics, and

Immunology. R.A. Levine, S. Milstien, and H.-Ch. Curtius (eds), Lakeshore

Publishing, MI, 1989

Unconjugated Pterins and Related Biogenic Amines. H.-Ch. Curtius, N. Blau,

and R.A. Levine (eds.) Walter de Gruyter, Berlin, New York, 1987

Unconjugated Pterins in Neurobiology: Basic and Clinical Aspects. W.

Lovenberg and R.A. Levine (eds.), Taylor and Francis, London, New York,

1987.

Memberships on Editorial Boards:

Pteridines

Journal of Neural Transmission

The American Journal of Chinese Medicine

Journal Reviewer: Analytical Biochemistry

Annals of New York Academy of Sciences

Archives of General Psychiatry

Biological Psychiatry

Brain Research

European Journal of Biochemistry


Journal of Neurochemistry

Journal of Pharmacology and Experimental Therapeutics

Molecular Neurobiology

Neurobiology of Aging

Neurochemistry International


Journal of Neurological Sciences

Journal of Neuroscience

Proceedings of the National Academy of Sciences

Proceedings of the Society for Experimental Biology and Medicine

Pteridines

Science



10

MEETINGS ORGANIZED:

May 2006 Conference on Complementary and Alternative Medicine and End-of-Life Care

Principal organizer and principal investigator funded by the Agency for

Healthcare Research and Quality (AHRQ) through the Small Grant Program

for Conference Support (PAR-00-141); amount of funding: $25,000.

April 2003 Thirteenth International Conference on Pteridines and Related Biogenic

Amines

Member of international organizing committee

Maui, Hawaii, USA

June 2001 Twelfth International Symposium on Pteridines and Folates


National Institutes of Health, Bethesda, MD, USA

March 2000 Twelfth International Conference on Pteridines and Related Biogenic Amines.


St. Moritz, Switzerland

March 1999 Eighteenth International Winter Workshop on Chemical, Biochemical, and

Clinical Aspects of Pteridines and Eleventh International Conference on

Pteridines and Related Biogenic Amines (combined meeting).


St. Christoph/Arlberg, Austria

April 1998 Tenth International Conference on Pteridines and Related Biogenic Amines

Principal Organizer

Salt Lake City, UT, USA

June 1997 Eleventh International Symposium on Chemistry and Biology of Pteridines and

Folates. Member of international organizing committee

Berchtesgaden, Germany

May 1996 Ninth International Conference on Pteridines and Related Biogenic Amines


Cairns, Queensland, Australia

March 1995 Eighth International Conference on Pteridines and Related Biogenic Amines




11

MEETINGS ORGANIZED (continued):

February 1994 Seventh International Conference on Pteridines and Related Biogenic Amines

Co-sponsored with Dr. Watanabe. Abstracts published in the journal,

Pteridines.

Hokkaido, Japan

March 1993 Tenth International Symposium on Chemistry and Biology of Pteridines and

Folates. Member of international organizing committee

Proceedings published (see books edited above)

Orange Beach, AL

June 1992 Sixth International Conference on Pteridines and Related Biogenic Amines and

Folates. Co-organized with Drs. Jeongbin Yim and Nenad Blau


Seoul, Korea

November 1991 Fifth International Conference on Pteridines and Related Biogenic Amines and

Folates. Co-organized with Drs. Richard Cotton and Nenad Blau


March 1990 Fourth International Conference on Pteridines and Biogenic Amines

Co-organized with Dr. Nenad Blau, Proceedings published (see books edited

above)


September 1989 Ninth International Symposium on Pteridines and Folic Acid Derivatives:

Chemical, Biological, and Clinical Aspects


Zurich, Switzerland

March 1989 Third International Conference on Pteridines and Related Biogenic Amines

Principal Organizer

Salt Lake City, UT

March 1988 Second International Conference on Pteridines and Related Biogenic Amines

Principal Organizer. Proceedings published (see books edited above)

Salt Lake City, UT

February 1987 First International Conference on Pteridines and Related Biogenic Amines

Co-organized with Professor H.-Ch. Curtius and Dr. N.Blau, Kinderspital

Zurich


Flims, Switzerland


12

MEETINGS ORGANIZED (continued):

June 1986 Tetrahydrobiopterin: Neural Function and Neuropsychiatric Disease

Co-organized with Dr. Gregory Kapatos, Sinai Research Institute

Detroit, MI

SUPERVISION OF PERSONNEL:

July 2012 – Present Corporate Wellness Resources, LLC

Responsible for developing content for in-person and online

group programs, including accelerated learning strategies,

automatic pattern interruption© technology, and Effective

Muscle Release© movement routines (see www.cwrnow.com)

April 2008 – July 2012 Henry Ford Health System, Center for Integrative Wellness

Directing all activities of the award-winning group pain and

stress alleviation programs (see awards and honors) offered

onsite to self-insuring corporations.

June 2002 - April 2008 Henry Ford Health System, Center for Integrative Medicine

Direct the activities of personnel at the Center, including 1

administrative manager, 3 customer service representatives, 2

acupuncturists, 2 mind-body therapists, 2 neuromuscular

therapists, 3 massage therapists, 2 holistic nutritionists, 1

chiropractor, 1 Feldenkrais practitioner, 4 research staff

members, and 1 counseling student clinical intern.

January 1999 - December 2006 Henry Ford Health System

Clinical trial supervision in complementary and integrative

medicine, serving as PI on several randomized, control clinical

trials including: 1) St. John Neuromuscular Therapy vs. control

relaxation massage for alleviating chronic, intractable migraine

and cervicogenic headaches; 2) complementary and integrative

medicine therapies vs. conventional physical therapy for

alleviating chronic low back pain; 3) acupuncture vs.

venlafaxine (Effexor) for alleviating hot flashes and other

vasomotor symptoms in breast cancer patients receiving

hormone therapy; 4) Hands-off group complementary treatment

of chronic musculoskeletal pain in the workplace at Chrysler

and Henry Ford Health System. These trials involve overseeing

the activities of approximately 20 people including many

complementary medicine practitioners, integrative medicine

research fellows, research study coordinators, data managers,

and interfacing with biostatistics personnel.


13

SUPERVISION OF PERSONNEL (continued):

January 1993 - March 2007 Henry Ford Health System

Direct the basic research activities as the Director of the

William T. Gossett Neurology laboratories, employing

postdoctoral fellows, research assistants, post-undergraduates,

college and high school students, and an administrative

assistant.

April 1992 - September 2002 Detroit Veterans Administration

Directed research laboratory that employed postdoctoral fellows

and research assistants.

October 1985 - December 1992 Director, Laboratory of Molecular Neurobiology, Lafayette

Clinic

Directed research laboratory that employed 1-2 postdoctoral

fellows, 2-3 technicians; mentored 1 medical student's research

project, and 1 graduate student's Ph.D. dissertation project.

Director, Clinical Chemistry Laboratory, Lafayette Clinic

3 medical laboratory technicians

Radiation Safety Officer, Lafayette Clinic (1990-1992)

Directed radiation usage activities of more than 50 employees

July 1982 - June 1985 Department of Pediatrics, Kinderspital Zurich (periodic visits)

3 technicians who worked on testing the ability of synthetic

analogues of tetrahydrobiopterin to penetrate the blood-brain

barrier and influence hydroxylase enzyme activity and biogenic

amine metabolism

UNIVERSITY/INSTITUTIONAL COMMITTEES:

January 2009 – July 2012 HFHS Wellness Ambassador Team member

Jan 2005 - December 2005 HFHS planning committee for “Your Journey to Wellness”

Program, offered to Detroit area churches

June 1999 - June 2002 Member, Complementary/Alternative Medicine Task Force

Henry Ford Hospital, Detroit, MI

May 1999 - October 2003 Member, Pain Management Strategy Committee

Veterans Administration VISN 11 (midwest VAs)


14

UNIVERSITY/INSTITUTIONAL COMMITTEES (continued):

September 1999 - October 2003 Member, Committee on Complementary and Alternative

Medicine


March 1997 - December 2001 Member, Task Force on Bioscientific Staff Development


October 1998 - December 2001 Member, Grant Development Committee


August 1977 - December 1998 Member, Task Force on Case Western Reserve University-

Henry Ford Health System Basic Science Curriculum


January 1997 - September 1998 Member, Small Projects Funding Committee


January 1994 - December 1997 Member, Finance committee, Department of Neurology


January 1995 - May 1996 Member, Research Purchasing Task Force


January 1996 - July 1999 Chairman, Research and Development Committee

John D. Dingle Veterans Administration, Detroit, MI

January 1993 - December 2001 Member, Research and Development Committee

John D. Dingle Veterans Administration, Detroit, MI

October 1986 - September 1988 Member, Curriculum Development Committee,

Cellular and Clinical Neurobiology Ph.D. Program

Dept. of Psychiatry and Behavioral Neurosciences


TEACHING ACTIVITIES:

Course coordination and lecture activity:

January 1997 - Present Lecturer, Neurology Pharmacotherapeutics, undergraduate

Department of Pharmaceutical Sciences

Wayne State University, Detroit, MI


15

TEACHING ACTIVITIES (continued):

September 1993 - August 1995 Course coordinator and lecturer, Basic Neurobiology



Fall 1993 Lecturer, Topics in Neurobiology

Department of Psychiatry Medical Residents

Henry Ford Hospital

October 1986 - March 1997 Member, Cellular and Clinical Neurobiology Program

Duties: lecturing and graduate student training



Spring 1981 Lecturer, General Neurochemistry

George Washington University, Washington, D.C.

Fall 1978 - Spring 1981 Lecturer, Advanced Topics in Pharmacology:

George Washington University

Fellows (Ph.D & M.D.) trained: Panagiotis Anastasiadis, Ph.D.

(*including sabbaticals) Krishnamoorthy Sankaran, Ph.D.

Randy Shoemaker, Ph.D.

Torbjoern Nygaard, M.D.*

Laurent Bezin, Ph.D.

Min Zhu, M.D.

Jane Foster, Ph.D.

Hao Jiang, Ph.D.

David Koubi, Ph.D.

Alba Rodriguez, Ph.D. (integrative medicine)

Dissertations directed:

May 2005 - December 2005 Hosted Maria Angoa Perez for Ph.D. thesis research

Ph.D. Degree to be granted by:

National University of Mexico, Mexico City, Mexico

January 1998 - December 2001 Co-supervisor for thesis of Laurent Groc (working in U.S.)

Ph.D. Degree granted by:

Laboratoire de Neuropharmacoligie Moleculaire

CNRS- UCBL UMR 5542

Lyon, France


16

TEACHING ACTIVITIES (continued):

January 1989 - March 1993 Supervised Ph.D. thesis of Panagiotis Anastasiadis

Cellular and Clinical Neurobiology Program

Department of Psychiatry and Behavioral Sciences

Wayne State University, Detroit, MI

Post-undergraduates mentored: Bruce Imerman (Wayne State University Medical School)

(subsequent career path listed) Jennifer Blitz (University of PA Medical School),

Martin Berent (Wayne State University Medical School)

Michael Flam (Arizona College of Osteopathic Medicine)

Ryan Stearn (Wayne State University Law School)

Undergraduates trained: James Neville (University of Michigan)

(university attended) Arthur Nugent (University of Michigan)

Kevin Kuzia (University of Michigan)

Claudia Reich (Oakland University)

Minority High School Students trained:

(subsequent university attended) Melisa Louie (University of Michigan)

Alfred Valrie (Dartmouth College)

Letteice Jones

Janea Lowe

Curriculum development:

January 1986 - September 1988 Member, Curriculum Development Committee

Ph.D. program in Cellular and Clinical Neurobiology

Department of Psychiatry and Behavioral Sciences


GRANT REVIEW COMMITTEES:

December 2003 - March 2007 National Institutes of Health, NINDS

Member, Special Review Panel

Reviewing applications for Morris K. Udall Parkinson's Disease

Research Centers of Excellence

March 2002 - Present Alzheimer’s Disease and Related Disorders Association

Ad-hoc reviewer

December 1999 - March 2000 National Institutes of Health

Member, Special Review Panel

National Center for Complementary and Alternative Medicine


17

GRANT REVIEW COMMITTEES (continued):

March 1995 - February 2002 Veterans Administration

Member, National Review Committee

“Research training initiative for historically black colleges and

universities and Hispanic-serving institutions”

September 1995 - October 1999 Veterans Administration

Chairman, National Review Committee

“Research training initiative for historically black colleges and

universities and Hispanic-serving institutions”

February 1987 National Institutes of Health

Ad-hoc reviewer for National Institute on Drug Abuse

GRANT SUPPORT:

Mar 2011 - Feb 2012 Blue Cross Blue Shield Michigan

“Group programs for stress and pain relief offered through

mainstream physician organizations”

P.I. - Robert A. Levine, Ph.D.

$380,000/1yr total costs

June 2004 - December 2007 Health Alliance Plan Quantum Leaps in Quality

“Improving Quality and Reducing Cost of Care in Patients with

Chronic Back Pain Using Integrative Medicine Approaches”


$1,000,000/3yr direct costs

June 2004 - May 2007 Susan Komen Breast Cancer Foundation

“Acupuncture for the Treatment of Vasomotor Symptoms in

Breast Cancer Patients Receiving Hormonal Therapy”

P.I. – Eleanor Walker, M.D. (Co-I: Robert A. Levine, Ph.D.)

$250,000/2yr direct costs

Sep 2005 - Aug 2006 National Institutes of Health- Agency for Healthcare Research

and Quality (AHRQ)

Small Grant Program for Conference Support (PAR-00-141)

“Conference on Complementary and Alternative Medicine and

End-of-Life Care”


$25,000/1 yr direct costs


18

GRANT SUPPORT (continued):

June 2000 - March 2004 National Institutes of Health (R01)

"Biopterin, Catecholamines, & NO in Regulating Apoptosis"


Total direct costs: $600,000


“St. John Neuromuscular Therapy for Intractable Headaches”


Total direct costs: $150,000 (funding provided by Gail Warden,

CEO, and Dr. Tom Royer, CMO)

October 1996 - September 2002 Veterans Administration, National Peer Review Merit Award

(2nd

funded competitive renewal) "Regulation of Nitric Oxide and Tetrahydrobiopterin-related

Gene Expression"



August 1992 - May 1997 National Institutes of Health, NINDS, 1 R01 NS28800

"Biopterin & Catecholamines in Aging and Neurodegeneration"



April 1995 - March 1997 Dystonia Medical Research Foundation

“GTP Cyclohydrolase I as a Marker for Dopa-responsive

Dystonia”



October 1993 - September 1996 Veterans Administration, National Peer Review Merit Award

(1st funded competitive renewal) "Regulation of Nitric Oxide and Tetrahydrobiopterin-related

Gene Expression"


April 1992 - March 1995* Veterans Administration, National Peer Review Merit Award

"Regulation of Biopterin and Catecholamine-related Gene

Expression "



*returned to central office (8/1/92) due to overlap with

NS28800.

Competitive renewal submitted (please see above)


19


September 1992 - May 1995 National Institutes of Health, NIA, 1 R01 AG10687

"Biopterin/Catecholamine Metabolism in Alzheimer's & Aging"



INVITED PRESENTATIONS (selected events):

(For presentations related to Complementary and Integrative Medicine, see pages 21-38)

June 2005 Fourth Stromboli Conference on Neuroimmunology, Aging, and Cancer: The

Reversal of Aging, Myth and Reality

Stromboli, Italy

April 2003 13th

International Conference on Pteridines and Related Biogenic Amines and

Folates

Maui, Hawaii

June 2001 11th

International Symposium on Chemistry and Biology of Pteridines and

Folates

NIH, Bethesda, MD

March 1999 18th

International Winter Workshop on Chemical, Biochemical, and Clinical

Aspects of Pteridines and 11th International Conference on Pteridines and

Related Biogenic Amines (joint meeting).

St. Christoph, Arlberg, Austria

April 1998 10th


Folates

Salt Lake City, UT

June 1997 11th


Folates

Berchtesgaden, Germany

October 1996 3rd

International Dystonia Symposium

Miami, FL

May 1996 9th


Folates

Port Douglas, North Queensland, Australia

March 1995 8th

International Conference on Pteridines and Related Biogenic Amines



20

INVITED PRESENTATIONS (continued):

February 1994 7th

International Conference on Pteridines and Related Biogenic Amines

Hokkaido, Japan

March 1993 10th


Folates

Mobile, AL

June 1992 6th


Folates

Soeul, Korea

June 1992 Osaka Bioscience Institute

Osaka, Japan

November 1991 9th


Folates


September 1989 9th

International Symposium on Pteridines and Folic Acid Derivatives:

Chemical, Biological, and Clinical Aspects

Zurich, Switzerland

November 1988 Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical

Center

Glen Oaks, NY

March 1988 Department of Pharmacology, University of Utah

Salt Lake City, Utah

June 1987 First International Conference on Neuroimmunomodulation, Aging, and

Cancer

Stromboli, Italy

April 1984 Department of Pharmaceutics, S.U.N.Y. at Buffalo

Amherst, NY

June 1983 Schering Pharmaceutical Company

West Berlin, Germany

December 1982 Neurobiology Colloquium, Psychiatric Hospital, University of Zurich

Zurich, Switzerland


21


July 1981 Department of Pharmacology, Kyushu University

Fukuoka, Japan

July 1981 Department of Biochemistry, Bombay Atomic Research Council

Bombay, India


22

Complementary and Integrative Medicine (CIM) Activities (Summary)

EMPLOYMENT:

July 2012 – Present Vice President, Wellness and High-Performance Strategies

Corporate Wellness Resources, LLC, Southfield, MI

http://www.CWRnow.com

April 2008 – July 2012 Director, Center for Integrative Wellness

Director, Integrative Wellness Research


Sept. 2000 - April 2008 Co-director, Henry Ford Center for Integrative Medicine

Director, Integrative Medicine Research


AWARDS AND HONORS:


Dr. Levine was the recipient of the Corporate Achievement

Award for group programs offered to large self-funding

corporations to provide relief of chronic pain, stress, and

symptoms of stress-related conditions. Levine operates on the

principle that the main way of reducing national healthcare

costs in the long-run is to produce sustained health

improvement. The group programs have demonstrated

improved health that is sustained for up to 16 months after

programs end. See online:

http://www.crainsdetroit.com/article/20110911/AWARDS05/30

9119983/wellness-programs-go-on-the-road






for Integrative Wellness. New for 2010 were programs offered

at Dow Chemical, Midland and the community program at New

Hope Missionary Baptist Church. The results of these

independent programs were equivalent and equal to the positive

outcomes produced in earlier years (see description below).

This project demonstrated that programs could be effective

when offered outside the Detroit Metro area (Midland) and

when delivered to an African American population in the faith-

based community.




23

CIM Activities Summary (continued):


2010 International Medical and Dental Hypnotherapy Association

Outstanding Research Award in the Mind-Body Medicine

Award. Presented at the annual meeting of the International

Medical and Dental Hypnotherapy Association and the

International Association of Counselors and Therapists.






for Integrative Wellness. New for 2009 was the tracking of

stress elimination in Chrysler and HFHS employees. Stress

elimination, defined as a score of 0 average stress in the last

week on a 0-10 scale (score of 0 is when more than 95% of the

time is spent free of unhealthy stress reactions), was reported by

14% of participants. Programs were reduced from 24 to 18

contact hours with no loss of results; elimination of chronic pain

conditions was 45%, and other validated measures were also

favorably impacted (disability, stress, and depression were

significantly reduced; sleep quality was significantly improved).


One of eight awardees in the Southeast Michigan area. Dr.

Levine was the recipient of a Corporate Achievement Award for

the Chrysler “We’ve Got Your Back” program. Chrysler

employees were treated in the workplace in groups of up to 48

people at a time with a hands-off complementary and alternative

medicine approach. After 24 contact hours over 6 months, 55%

of reporting employees eliminated back pain compared with 0%

of untreated, randomized controls. There were also significant

reductions in stress, disability, and depression symptoms, as

well as improvements in sleep quality.


24




Competition Winner for Chrysler & HFHS Pain Alleviation

Program

Henry Ford Health System recognized the quality of the group

pain alleviation programs offered by the Center for Integrative

Wellness. The programs offered under the umbrella of “Pain

Free in 2008” received the award for the positive health

outcomes achieved with employees of Chrysler (“Pain Free

Zone”) and HFHS ( “Living a Pain Free Life”). All

musculoskeletal pain conditions were included in the same

group and employees received 24 contact hours over about 7

months; 35% of all chronic pain conditions were eliminated.

There were also significant reductions in stress, disability, and

depression symptoms, as well as improvements in sleep quality.

2007 Focus on People 2007 Award for Chrysler Back Pain Program


System to Dr. Levine and his team for creating and delivering

the “We’ve Got Your Back” program to Chrysler employees

(results described above).


Competition Winner for Chrysler Back Pain Program

Henry Ford Health System recognized the achievement in

enhancing quality for a major System employer group through

offering the “We’ve Got Your Back” program to Chrysler

employees (results described above).

2005 Focus on People 2005 Award


System for participation in the Journey to Wellness Program, an

educational and intervention program designed to support the

health and wellness of members of city of Detroit churches.

2004 Distinguished Researcher in Hypnotherapy Award Presented at the International Medical and Dental Hypnotherapy

Association annual international meeting.


25



2002 Deputy Director for National Center for Complementary and

Alternative Medicine at NIH- Interviewee

One of 3 individuals selected from several hundred applicants to

interview for the position of Deputy Director reporting to

Steven Straus, then the Director of NCCAM. Although not

selected, this was recognition of Dr. Levine’s broad expertise in

conventional basic and clinical research, experience and

productivity in NIH grant-funded research and peer-review

publications, being a practitioner of integrative medicine

therapies, and having expertise in integrative medicine basic

and clinical research.

EDUCATION AND CERTIFICATIONS:

January 2002 - April 2002 Hypnotherapy Certification (C.Ht.)

Infinity Institute, Royal Oak, MI

Basic and advanced hypnosis, regression analysis, guided

imagery, holistic hypnoanalysis

March 2002 - March 2007 Advisory Board Member, International Medical and Dental

Hypnotherapy Association

September 2000 - May 2001 Medical Acupuncture for Physicians (Dr. Joe Helms)

UCLA School of Medicine, Los Angeles, CA

300 CME credits received

Fall 1996 - Spring 2001 St. John Neuromuscular Therapy (NMT) training through

attending the following seminars: NMT1, NMT2, NMT3,

NMT5, NMT6, NMT7 offered by the St. John Neuromuscular

Pain Relief Institute, Tampa, FL. (NMT, developed by Paul St.

John, is now called Neurosomatic Therapy)


26


UNIVERSITY/INSTITUTIONAL COMMITTEES:

January 2009 – July 2012 HFHS Wellness Ambassador Team member

January 2007 – July 2012 Member, Advisory Committee for wellness activities and

Research Committee member at the new West Bloomfield

Wellness Hospital

June 1999 - June 2002 Member, Complementary/Alternative Medicine Task Force


September 1999 - October 2003 Member, Committee on Complementary and Alternative

Medicine


SUPERVISION OF PERSONNEL:

July 2012 – Present Corporate Wellness Resources, LLC

Responsible for developing content for in-person and online

group programs, including accelerated learning strategies,

automatic pattern interruption© technology, and Effective

Muscle Release© movement routines (see www.cwrnow.com)

April 2008 – July 2012 Henry Ford Health System, Center for Integrative Wellness

Directing all activities of the award-winning group pain and

stress alleviation programs (see awards and honors) offered

onsite to self-insuring corporations.

June 2002 - April 2008 Henry Ford Health System, Center for Integrative Medicine

Direct the activities of personnel at the Center, including 1

administrative manager, 3 customer service representatives, 2

acupuncturists, 2 mind-body therapists, 2 neuromuscular

therapists, 3 massage therapists, 2 holistic nutritionists, 1

chiropractor, 1 Feldenkrais practitioner, 4 research staff

members, and 1 counseling student clinical intern.


Clinical trial supervision using CIM modalities, serving as PI or

co-I on randomized, control clinical trials including:

1) Neurosomatic Therapy vs. relaxation massage for relieving

chronic migraine and cervicogenic headaches; (con’d below)


27


SUPERVISION OF PERSONNEL (continued):

2) CIM modalities vs. conventional physical therapy for

alleviating chronic low back pain in HFHS patients. These trials

involve overseeing the activities of approximately 20 people

including many complementary medicine practitioners,

integrative medicine research fellows, research study

coordinators, data managers, and interfacing with biostatistics

personnel.

3) acupuncture vs. venlafaxine (Effexor) for alleviating hot

flashes and other vasomotor symptoms in breast cancer patients

receiving hormone therapy.

4) in-person group programs for relief of chronic back pain at

Chrysler.

5) in-person group programs for relief of chronic all

neuromuscular pain condition, stress, and symptoms of stress-

related conditions (employees at Chrysler, HFHS, Dow

Chemical, and patients at MI BCBS).

MENTORING OF PERSONNEL:

June 2002 - November 2008 Mentorship of CIM practitioners in research and developing

multimodal protocols at the Center for Integrative Medicine:

includes 12 practitioners of many disciplines, including

acupuncture/TCM, mind-body therapies, holistic nutrition,

massage therapy, St. John Neuromuscular Therapy,

chiropractic, Feldenkrais movement reeducation, among others

November 1999 – July 2012 Alba Rodriguez, Ph.D.

August 1998 - March 2001 Elizabeth Eckert, Ph.D.: Mentored dissertation research for

Ph.D. degree from Greenwich University

GRANT SUPPORT:

Mar 2011 - Feb 2012 Blue Cross Blue Shield Michigan

“Group programs for stress and pain relief offered through

mainstream physician organizations”


$380,000/1yr total costs


28



June 2004 - May 2007 Health Alliance Plan Quantum Leaps in Quality

“Improving Quality and Reducing Cost of Care in Patients with

Chronic Back Pain Using Integrative Medicine Approaches”


$1,000,000/3yr direct costs

June 2004 - May 2007 Susan Komen Breast Cancer Foundation

“Acupuncture for the Treatment of Vasomotor Symptoms in

Breast Cancer Patients Receiving Hormonal Therapy”

P.I. – Eleanor Walker, M.D. (Co-I: Robert A. Levine, Ph.D.)

$250,000/3yr direct costs

Sep 2006 - Aug 2006 National Institutes of Health- Agency for Healthcare Research

and Quality

“Conference on Complementary and Alternative Medicine and

End-of-Life Care”

P.I. – Robert A. Levine, Ph.D.

$25,000/1 yr direct costs


“St. John Neuromuscular Therapy for Intractable Headaches”



GROUP TREATMENT PROGRAMS:

1) Corporate Wellness Resources (2012-2013). Offering community-based group programs

entitled, “Ultimate Stress and Pain Free Living” in the southeast MI region.

2) Blue Cross Blue Shield Michigan (2011-2012). Contracted by the PGIP (Physician Group

Incentive Program) to treat 600 BCBSM patients for chronic pain and stress relief, recruited

through the Henry Ford Medical Group (Henry Ford Health System physician group with

over 1,200 physicians). Served as a model for recruitment of patients to group programs for

chronic pain and stress relief using other physician groups in MI.

3) Henry Ford Health System, “Stress and Pain Free Living” (2010). Team leader in hands-off

group treatment program using CAM modalities to alleviate stress and chronic

musculoskeletal pain for HFHS employees and eligible family members. Other stress-related

diseases were monitored for changes in health outcomes, including diabetes, heart disease and

high blood pressure, obesity, depression, and asthma, among others.


29


GROUP TREATMENT PROGRAMS (continued):

4) Dow Chemical, Midland, MI, “Pain Free Living” (2010). Team leader in hands-off group

treatment program using CAM modalities to reduce and eliminate pain in all musculoskeletal

pain conditions. Offered to eligible Dow employees, retirees, and family members.

5) Henry Ford Health System, “Stress and Pain Free Living” (2009). Same description as 2010.

6) Chrysler LLC, “StressLess” (started summer of 2008). Team leader in hands-off group

treatment program for Chrysler employees using CAM modalities to reduce stress and

monitor other health outcomes in employees with diabetes, heart disease and high blood

pressure, obesity, depression, and asthma, among others.

7) Chrysler LLC, “Pain Free Zone” (2008). Team leader in hands-off group treatment program

using CAM modalities to reduce and eliminate pain in all musculoskeletal pain conditions.

8) Henry Ford Health System, “Living the Pain-Free Life” (2008). Team leader in hands-off

group treatment program using CAM modalities to reduce and eliminate pain in all

musculoskeletal pain conditions.

9) DaimlerChrysler (DCC; now Chrysler, LLC), “We’ve Got Your Back” Program (2007).

Team leader of group treatment program using CAM modalities of 96 employees at the DCC

World Headquarters in Auburn Hills. Treatment started in January 2007 and was completed in

June 2007. At the end of the treatment phase, 55% of employees had eliminated their pain

compared to 0% in the untreated randomized controls. 8 months after the end of the program,

46% reported being pain free (a drop of 9%)

10) HFHS “Journey to Wellness” Program (2004-5). Participated on the planning committee for

the Journey to Wellness Program offered to Detroit churches. This multi-module program

involves providing education to church members on many health topics from cardiovascular

and heart disease to cancer and stress. Presenting to church members lectures on stress

alleviation and delivering group intervention to facilitate recognition and dissipation of stress

using mind-body therapy.

11) City of Livonia Police Department (Fall 2003). Stress alleviation program delivered using

multimodal integrative protocol. Program was delivered to 20 police officers (2 contact hours

per week for 6 weeks). Program including group lectures on nutrition/lifestyle, group

acupuncture, group somatic movement reeducation, and group hypnotherapy. Data collection

demonstrated positive benefits directly after program and at the 8 month follow-up evaluation.


30

MEMBERSHIPS ON EDITORIAL BOARDS:


ABSTRACTS AND PUBLICATIONS:

1. Rodriguez AI, St. John P, Mitsias P, Eckert E, Rau BJA, Tashman S, Peterson E and Levine, RA.

Treatment of intractable headaches via complementary & alternative medicine using St. John

neuromuscular therapy. Society for Neuroscience Abstracts, San Diego, CA, November, 2001.

2. Rodriguez AI, St. John P, Mitsias P, Eckert E, Rau BJA, Conrad K, Tashman S, and Levine RA.

Quantitative Assessment of 3D Postural Distortion As A Tool In Alleviating Chronic Pain.

Society for Neuroscience Abstracts, Orlando, FL, November, 2002.

3. Rodriguez AI, Jiang H, Kuo K, Kuo J, Jackson Hunter T, Gautam SC, Corcoran GB, Seidman

MD, and Levine RA. Resveratrol-induced apoptotic death in cultured human U251 glioma:

Involvement of cell cycle-related proteins and nitric oxide. 1st Annual International Conference

on Cancer and Integrative Medicine, Chicago, IL, October, 2002.

4. Levine RA, Zhang L , Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Jackson

Hunter T, Corcoran GB, Seidman MD, and Jiang H. Resveratrol induces apoptotic death of

human U251 glioma cells. Society for Neuroscience Abstracts, New Orleans, LA, November,

2003.

5. Rodriguez AI, Pocock J, and Levine RA. Reduction of chronic pain using complementary and

alternative medicine modalities, Society for Neuroscience, San Diego, CA, November 2004.

6. Rodriguez AI, Mandel SS, Nunez R, Pocock JR, Ball RM, and Levine RA. Novel treatment of

chronic low back pain (LBP): complementary and alternative medicine (CAM) therapies reduce

or eliminate pain in a controlled randomized trial. Society for Neuroscience, Washington, D.C.,

November, 2005.

7. Levine RA, Mandel SS, Nunez R, Pocock JR, Ball RM, Seidman MD & Rodriguez AI.

Randomized Controlled Clinical Trial Testing Complementary and Alternative Medicine

Therapies to Alleviate Chronic Low Back Pain. North American Research Conference on

Complementary & Integrative Medicine, Edmonton, Alberta, Canada, 2006.

8. Rodriguez AI, Pocock JR, Ball RM & Levine RA. Tracking Health Outcomes of Complementary

and Alternative Medicine Treatments in an Integrative Medicine Center. North American

Research Conference on Complementary & Integrative Medicine, Edmonton, Alberta, Canada,

2006.


31


9. Walker EM, Rodriguez AI & Levine RA. Acupuncture for the Treatment of Vasomotor

Symptoms in Breast Cancer Patients Receiving Hormonal Therapy: A Preliminary Report. North

American Research Conference on Complementary & Integrative Medicine, Edmonton, Alberta,

Canada, 2006.

10. Levine RA, St. John P, Eckert E, Rau BJA, Lang DR, Tashman S, Peterson EL, Conrad KA,

Mitsias P & Rodriguez AI. St. John Neuromuscular Therapy is Effective in Reducing Symptoms

of Intractable Headache: A Complementary and Integrative Medicine Pilot Study. North


Canada, 2006.

11. Levine RA, Jiang H, Kuo Kelly, Kuo J, Jackson-Hunter T, Gautam SC, Corcoran GB, Seidman

MD & Rodriguez AI. Resveratrol-induced apoptotic death in human U251 glioma cells. North


Canada, 2006.

12. Rodriguez AI, Walker EM, Kohn B, Ball RM, Pegg J, & Levine RA. Acupuncture is Superior to

Pharmacotherapy Management of Hot flashes and Other Side Effects of Conventional Breast

Cancer Care: A Preliminary Report. Integrative Medicine for Healthcare Organizations

Conference, San Diego, CA, 2007.

13. Levine RA, Nunez R, Mandel SS, Ball RM, & Rodriguez AI. Direct Comparison of

Conventional Physical Therapy vs. Two Different CAM Approaches for Chronic Back Pain: a

Randomized Clinical Trial (RCT). Integrative Medicine for Healthcare Organizations

Conference, San Diego, CA, 2007.

14. Levine RA, Nunez R, Ball RM, & Rodriguez AI. Pioneering a Hands-off Group Intervention for

Chronic Back Pain: A Paradigm Shift to Reduce Cost and Practitioner Contact Time by Over

Ninety Percent. Integrative Medicine for Healthcare Organizations Conference, San Diego, CA,

2007.

15. Levine RA, Rodriguez AI, Ball R, Asbell DA, Walsh M. Pain Elimination in the Chrysler and

HFHS Workforce. Poster: HFHS Quality Exposition Abstracts, Detroit, MI, 2008.

16. Walker EM, Rodriguez AI, Kohn B, Pegg J, Ball RM and Levine RA. Acupuncture for the

treatment of vasomotor symptoms in breast cancer patients receiving hormone suppression

treatment. International Journal of Radiation Oncology Biology Physics, 72(1): S103-S03, 2008.

17. Levine, RA: Hypnotherapy for the Treatment of Gastroesophageal Reflux Disease, Alternative

and Complementary Therapies. 15(1): 37, 2009.


32


18. Levine RA, Rodriguez AI, Nunez R, Ball R, Thayer B, Salter R, Asbell DA, Walsh M, Wisdom

K. Stress & Pain Elimination in the Chrysler and Henry Ford Health System (HFHS) Workforce.

HFHS Quality Exposition Abstracts, Detroit, MI 2009.

19. Walker EM, Rodriguez AI, Kohn B, Ball RM, Pegg J, Pocock JR, Nunez R, Peterson E, Jakary S,

& Levine RA. Acupuncture versus Venlafaxine for the Management of Vasomotor Symptoms in

Hormone Positive Breast Cancer Patients: A Randomized Controlled Trial, Journal of Clinical

Oncology, 28: 634-640, 2010.

20. Levine RA, Nunez R, Ball RM, & Rodriguez AI. An Integrative Group Wellness Program

Reduces/Eliminates Chronic Back Pain. Academy Health Annual Research Meeting, Boston,

MA, Jun 2010.

21. Rodriguez AI, Nunez R, Ball RM, Nowicki J, & Levine RA. An Integrative Group Wellness

Program Concurrently Reduces Pain and Stress, and Improves Stress-Related Chronic Illnesses.

Panelist: Academy Health Annual Research Meeting, Boston, MA, Jun 2010.

22. Levine RA, Nunez R, Ball RM, & Rodriguez AI. An Integrative Group Wellness Program

Concurrently Reduces Pain, Stress, and Improves Stress-Related Chronic Illnesses. Corporate

Wellness Conference, Los Angeles, CA, Sep 2010.

23. Nunez R, Rodriguez AI, Ball RM, & Levine RA. An Interactive Demonstration of Somatic

Functional Therapy: Implications for Enhancing the Effectiveness of Health and Wellness

Programs. National Wellness Conference. Corporate Wellness Conference, Los Angeles, CA,

Sept 2010.

24. Rodriguez AI, Nunez R, Ball RM, Wisdom K, & Levine RA. Group Wellness Program

Reduces/Eliminates Pain and Stress in the Corporate Workforce and Local Faith-Based

Community. 2010 Conference on Pain, Plymouth, MI, Oct 2010.

25. Levine RA & Rodriguez AI. Growing Wellness: Using Clinical Trials to Prove Corporate and

Faith-based Community Wellness Programs Improve Health, Reduce Healthcare Costs, and

Optimize Return on Investment. National Wellness Conference, Stevens Point, WI, July 2011

Speaker: National Wellness Conference, Stevens Point, WI, Jul 2011.

26. Levine RA, St. John P, Mitsias P, Eckert E, Rau BJA, Conrad K, Ball, RM, Peterson EL, and

Rodriguez, AI. Integrative Neurosomatic Therapy Reduces Symptoms of Intractable Chronic

Headaches, Headache, to be submitted.

27. Rodriguez AI, Ball RM, Peterson E, Cogan CM, Ball RM, and Levine RA. Tracking Health

Outcomes of Complementary and Alternative Medicine Treatments in an Integrative Medicine

Center, BMC Complementary and Alternative Medicine Journal, to be submitted.


33


28. Levine RA, Rodriguez AI, Nunez R, Anderson K, Collon DJ, Rapp J, and Seidman MD. Hypnosis

and Acupuncture as the Primary Modes of Anesthesia during Anterior Cruciate Ligament

Reconstruction Surgery (in preparation).

29. Levine RA, Rodriguez AI, Nunez R, Ball RM, Mandel SS, Jackson-Schulte O, Peterson EL, and

Seidman MD. A Multimodal Complementary and Alternative Medicine Approach is More

Effective than Conventional Physical Therapy for Eliminating Chronic Back Pain: A Randomized

Controlled Trial (in preparation).

30. Levine RA, Nunez R, Ball RM, Peterson EL, and Rodriguez AI. Reducing and Eliminating

Chronic Back Pain using a Hands-Off Group Intervention with Complementary and Alternative

Medicine Therapies: A Randomized Controlled Trial in the Corporate Workplace (in preparation).

MEDIA COVERAGE OF DR. LEVINE’S CIM ACTIVITIES (selected events):

Jul 2004 - Present Co-host of live weekly radio talk show, “Wellness Action Report”

WNZK, 690 AM band, covering wide-ranging health topics from alternative to

conventional and integrative medicine.

Dec 2002 National TV and radio coverage of HFHS press release

Anterior cruciate ligament reconstruction knee surgery using hypnosis and

acupuncture successfully to replace general and spinal anesthesia

Nov 2002 Minds of Medicine

WXYZ (ABC) TV covering HFHS Center for Integrative Medicine; topics

included treatments of failed back surgery syndrome and ACL reconstruction

knee surgery using hypnosis and acupuncture to replace general and anesthesia

July 2002 The Detroit News

The Use of Mind-Body Connection Techniques to Support Birthing

Feb 18, 2002 Henry Ford Health System Monitor

“Acupuncturist offers another healing path”

Nov 14, 2001 Detroit News

“Neuromuscular therapy brings the body back into alignment and eases pain”

Oct 3, 2001 Detroit News

“Holistic healing: Ancient ideas are new again”

Apr 23, 2001 Henry Ford Health System Monitor

“Yoga is the connection between mind, body”


34


MEDIA COVERAGE OF DR. LEVINE’S CIM ACTIVITIES (selected events):

Sep 11, 2000 Henry Ford Health System Monitor

“Planned center integrates styles of medicine”

INVITED PRESENTATIONS (selected from a larger sample):

Sept 2010 Corporate Wellness Conference

“An Integrative Group Wellness Program Concurrently Reduces Pain, Stress,

and Improves Stress-Related Chronic Illnesses Panel presentation.”

Los Angeles, CA

May 2010 Hypno-Expo 2010 (combined conference of the Association of Counselors and

Therapists and the International Medical and Dental Hypnotherapy

Association)

“Pain and Stress Elimination Techniques Used in Large Group Clinical

Research and Practice”

Daytona Beach, FL

April 2009 Invited Guest Lecture

“Group Hands-off Complementary and Alternative Medicine Treatment

Approach on site at Chrysler with Employees Having Chronic Back Pain”

Lyon, France

May 2008 Integrative Medicine for Healthcare Organizations

“A Cost-Effective and Efficient, Hands-off Group Intervention with

Employees at Chrysler LLC, Michigan, Reduces and Eliminates Chronic Back

Pain”

Phoenix, AZ

May 2008 Integrative Medicine for Healthcare Organizations

“Multimodal Complementary and Alternative Medicine (CAM) Approaches

Are Superior to Conventional Physical Therapy (PT) for Reducing and

Eliminating Chronic Back Pain: A Randomized Clinical Trial (RCT)”

Phoenix, AZ

April 2008 Institute for Health and Productivity Management

“Group Hands-off CAM Treatment Approach on site at Chrysler with

Employees Having Chronic Back Pain”

Orlando, FL


35



April 2007 Integrative Medicine for Healthcare Organizations

“Group Treatment of Chronic Back Pain Using CAM for DaimlerChrysler

Employees is as Effective and Much Less Costly Than 1-on-1 Treatment with

Physical Therapy”

San Diego, CA

May 2006 The North American Research Conference on Complementary & Integrative

Medicine

“Tracking Health Outcomes of Complementary and Alternative Medicine

Treatments in an Integrative Medicine Center”

Edmonton, Alberta, Canada


Medicine

“Randomized controlled clinical trial testing complementary and alternative

medicine therapies to alleviate chronic low back pain”



Medicine

“Resveratrol-induced apoptotic death in human U251 glioma cells”



Medicine

“Acupuncture for the Treatment of Vasomotor Symptoms in Breast Cancer

Patients Receiving Hormonal Therapy: A Preliminary Report”



Medicine

“St. John Neuromuscular Therapy is Effective in Reducing Symptoms of

Intractable Headache: A Complementary and Integrative Medicine Pilot

Study”


May 2006 Conference on Complementary and Alternative Medicine (CAM) and End-of-

Life Care

“The Critical Role of Research in Integrating CAM into End-of-Life Care"

Conference organizer and keynote speaker in Livonia, MI


36



June 2005 Fourth Stromboli Conference on Neuroimmunology, Aging, and Cancer: The

Reversal of Aging, Myth and Reality

“The Mind-body Connection as a Key Component of a Multimodal Strategy to

Alleviate Stress, and Achieve Longevity and Optimal Health”

Stromboli, Italy

October 2004 International Medical and Dental Hypnotherapy Association

“Hypnotherapy as a Key Intervention in Multimodal Therapeutic Approaches

to Improving and Resolving Chronic Illness”

Keynote speaker at the international symposium in Troy, MI

January 2004 Integrative Medicine for Healthcare Organizations

“Evidence of Efficacy: Tracking Health Outcomes of CAM Treatments in an

Integrative Medicine Center”

San Diego, CA


“Practical Applications of Hypnotherapy in an Integrative Medicine Clinic”

Royal Oak, MI

September 2003 Michigan Tremor Support Group Annual Conference

“Can Integrative Medicine Work for You?”

Berkley, MI

July 2003 Crittenton Hospital

“CAM Treatments for Cancer and Optimizing Health: A New Paradigm”

Rochester, MI

June 2003 Breast and Cervical Cancer Control Program

“Integrative Medicine for Cancer Treatment and Optimizing Health”

Bellaire, MI

May 2003 North American Womens Business Association (NAWBO)

“Complementary & Alternative Medicine (CAM): Why it’s Important You

Know About it!”

Roseville, MI

March 2003 City of Livonia Government

“Complementary and Integrative Medicine: How Can You Use it to Manage

Your Stress?”

Livonia, MI


37



March 2003 Wayne State University Physicians Assistant Program

“The Integration of Complementary Therapies into Conventional Medicine:

The Future Key to Optimal Healing, Health, and Longevity”

Detroit, MI

March 2003 Integrative Medicine Symposium

“The Science and Philosophy of Integrative Medicine”

Windsor, Canada

February 2003 Automobile Alliance International

“The Integration of Complementary Therapies into Conventional Medicine:

The Future Key to Optimal Healing, Health, and Longevity”

Southgate, MI

November 2002 Providence Hospital

“Research on Complementary and Integrative Medicine: Expanding the

Possibilities of Healthcare”

Southfield, MI


“Hypnotherapy: Key Modality in Multimodal Complementary and Integrative

Medicine Therapy”

Royal Oak, MI

October 2002 Michigan Tremor Support Group

“Optimizing Health Through Complementary and Integrative Medicine: You

Do Have a Choice”

West Bloomfield, MI

October 2002 Wayne County Community College

“Incorporating Integrative Medicine into Medical Practice: Critical Roles for

Research and Education”

Detroit, MI

October 2002 Renaissance Unity Church

“Rational Use of Pharmaceuticals and Complementary Medicine Therapies”

Warren, MI


38



September 2002 National Center for Complementary and Alternative Medicine (NCCAM)

“Incorporating Integrative Medicine into Medical Practice: Critical Roles for

Research and Education”

Bethesda, MD

May 2002 Church of Today

"Holistic Healing in Western Medicine"

Warren, MI

April 2002 Mind-Body-Spirit Festival

“New Avenues for Holistic Healing in Western Medicine”

Rochester, MI

April 2002 West Bloomfield Breast Cancer Support Group

“Cancer Treatment Using Complementary and Integrative Medicine: Creating

Balance in the Human Host”

West Bloomfield, MI

March 2002 Birmingham Rotary Club

“The Integration of Alternative and Conventional Therapies: A New Approach

to Providing Healthcare”

Birmingham, MI

March 2002 Henry Ford Health Sciences Center Research Seminar

“Research and Clinical Care in Henry Ford Health System’s Center for

Complementary and Integrative Medicine: Expanding the Possibilities of

Healthcare”

Detroit, MI

February 2002 Good Company Cable TV Show

“Complementary and Integrative Medicine”

Dearborn, MI

January 2002 Dearborn Rotary Club

“The Integration of Alternative and Conventional Therapies: A New Paradigm

for Medical Care in the United States”

Dearborn, MI


39



November 2001 Cancer Care Symposium, Mercy Hospital

“Market Presence, Research, and Ethics of Complementary and Integrative

Medicine: Emphasis on Cancer Treatment”

Port Huron, MI

September 2001 American College of Physicians, American Society of Internal Medicine

“Complimentary and Integrative Medicine (CIM): Market Presence, Ethics,

and Research”

Traverse City, MI

May 2001 Christus Health System

“Complimentary and Integrative Medicine (CIM): Market Presence, Ethics,

and Research”

San Antonio, TX

February 2001 Department of Neurology Grand Rounds, Henry Ford Health System

“Complementary and Alternative Medicine (CAM) in the Department of

Neurology, HFHS”

Detroit, MI

January 2001 Department of Pharmaceutical Sciences, Wayne State University

“The Arrival of Complementary and Alternative Medicine (CAM): Impact on

Conventional Western Medicine”

Detroit, MI

December 1999 Ethics Advisory Council, Henry Ford Health System

“Ethics and Complementary/Alternative Medicine (CAM)”

Detroit, MI

September 1999 Board of Governors, Henry Ford Health System

“Complementary/Alternative Medicine Activities in the Henry Ford Health

System”

Detroit, MI

End of Integrative Medicine Activity Summary


40

BIBLIOGRAPHY

PUBLICATIONS IN SCIENTIFIC JOURNALS:

1. Robinson, D.S., Levine, R.A., Williams, A. and Statham, N.: Hydroxylase cofactor in human

CSF- An index of central aminergic activity. Psychopharm. Bull. 14: 49-51, 1978.

2. Van Kammen, D.P., Levine, R.A., Sternberg, D., Ballenger, J., Marder, S., Post, R. and Bunney,

W. Jr.: Preliminary evaluation of hydroxylase cofactor in human spinal fluid: Potential

biochemical and clinical relevance in the study of psychiatric disease. Psychopharm. Bull.

14: 51-52, 1978.

3. Levine, R.A., Kuhn, D.M. and Lovenberg, W.: Regional distribution of hydroxylase cofactor in

rat brain. J. Neurochem. 32: 1575-1578, 1979.

4. Lovenberg, W., Levine, R.A., Robinson, D.S., Ebert, M., Williams, A.C. and Calne, D.B.:

Hydroxylase cofactor activity in cerebrospinal fluid of normal subjects and patients with

Parkinson's Disease. Science 204: 624-626, 1979.

5. Levine, R.A., Williams, A.C., Robinson, D.S., Calne, D.B. and Lovenberg, W.: Analysis of

hydroxylase cofactor activity in human cerebrospinal fluid of patients with Parkinson's disease.

Advances in Neurology, 24: 303-307, 1979.

6. Williams, A.C., Eldridge, R., Levine, R.A., Lovenberg, W. and Paulson, G.: Low CSF

hydroxylase cofactor (tetrahydrobiopterin) levels in inherited dystonia. Lancet 2 8139: 410-411,

1979.

7. Williams, A., Ballenger, J., Levine, R.A., Lovenberg, W. and Calne, D.B.: The effect of aging

on CSF hydroxylase cofactor levels. Neurology 30: 1244-1246, 1980.

8. Williams, A.C., Levine, R.A., Calne, D.B., Chase, T.N. and Lovenberg, W.: CSF hydroxylase

cofactor levels in some neurological diseases. J. Neurosurgery and Psychiatry 43: 735-738, 1980.

9. Hanson, G. R., Alphs, L., Wolf, W., Levine, R.A. and Lovenberg, W.: Haloperidol-induced

reduction of nigral substance P-like immunoreactivity: A probe for the interaction between

dopamine and substance P neuronal systems. J. Pharmacol. Exp. Ther. 218: 568-574, 1981.

10. Levine, R.A., Miller, L. and Lovenberg, W.: Tetrahydrobiopterin in the striatum: Localization in

dopamine nerve terminals and its role in catecholamine synthesis. Science 214: 919-921, 1981.

11. Garbutt, J.C., van Kammen, D.P., Levine, R.A., Sternberg, D.E., Murphy, D.L., Ballenger, J.,

Bunney, W.E., Jr. and Lovenberg, W.: Cerebrospinal fluid hydroxylase cofactor in

schizophrenia. Psychiatry Res. 6: 145-151, 1982.


41

PUBLICATIONS IN SCIENTIFIC JOURNALS (continued):

12. Curtius, H.-Ch., Niederwieser, A., Levine, R.A. and Muldner, H.: Effectiveness of

tetrahydrobiopterin in the treatment of Parkinson's disease. Adv. Neurol. 33: 1983.

13. LeWitt, P., Miller, L., Insel, T., Calne, D., Lovenberg, W., Levine, R.A. and Chase, T.: Tyrosine

hydroxylase cofactor (tetrahydrobiopterin) in Parkinsonism. Adv. Neurol. 40: 459-462, 1983.

14. Curtius, H.-Ch., Niederwieser, A., Levine, R.A., Lovenberg, W., Woggon, B., and Angst, J.:

Successful treatment of depression with tetrahydrobiopterin. Lancet l: 657-658, 1983.

15. Heintel, D., Ghisla, S., Curtius, H.-Ch., Niederwieser, A., and Levine, R.A.: Biosynthesis of

tetrahydrobiopterin: Possible involvement of tetrahydropterin intermediates. Neurochem. Int. 6:

141-155, 1984.

16. Levine, R.A. and Lovenberg, W.: CSF tetrahydrobiopterin levels in patients with affective

disorders. Lancet l: 284, 1984.

17. Culvenor, A.J., Miller, L.P., Levine, R.A., and Lovenberg, W.: Effect of methotrexate on

biopterin levels and synthesis in rat cultured pineal glands. J. Neurochem. 42: 1707-1714, 1984.

18. Levine, R.A., Pollard, H.B., and Kuhn, D.M.: A rapid and simplified assay method for tyrosine

hydroxylase. Anal. Biochem. 143: 205-208, 1984.

19. Kelner, K.L., Levine, R.A., Morita, K., and Pollard, H.B.: A comparison of trihydroxyindole and

HPLC/electrochemical methods for catecholamine measurement in adrenal chromaffin cells.

Neurochem. Int. 7: 373-378, 1985.

20. LeWitt, P.A., Levine, R.A., Lovenberg, W., Pomara, N., Stanley, M., Schlick, P., Roberts, R.,

and Gurevich, D.: Biopterin, neopterin, and monoamine neurotransmitter metabolites in

Alzheimer-type dementia. Neurology, 35: 265, 1985.

21. LeWitt, P., Miller, L., Levine, R.A., Lovenberg, W., Newman,R., Papavasiliou, A., Rayes, A.,

Eldridge, R., and Burns, R. Tetrahydrobiopterin in dystonia: Identification of abnormal

metabolism and therapeutic trials. Neurology 36: 760-764, 1986.

22. LeWitt, P., Miller, L., Levine, R.A., Lovenberg, Newman, R., Papavasiliou, A., Rayes, A.,

Eldridge, R., and Burns, R. Pterin Abnormalities in Dystonia: A Metabolic Marker with

Therapeutic Implications. Adv. Neurol. 50: 193-201, 1988.

23. Levine, R.A., Zoephel, G.P., Niederwieser, A., and Curtius, H.C.: Entrance of tetrahydropterin

derivatives in brain after peripheral administration: Effect on biogenic amine metabolism. J.

Pharmacol. Exp. Ther. 242: 514-522, 1987.


42


24. Fink, J.K., Ravin, P., Argoff, C., Levine, R.A., Brady, R., Hallett, M., and Barton, N.:

Tetrahydrobiopterin administration in biopterin-deficient progressive dystonia with diurnal

variation. Neurology, 39: 1393-1395, 1989.

25. Levine, R.A., Kapatos, G., Kaufman, S., and Milstien, S.: Immunological evidence for the

requirement of sepiapterin reductase for tetrahydrobiopterin biosynthesis in brain. J. Neurochem.,

54: 1218-1224, 1990.

26. Wolf, W.W., Anastasiadis, P.A., Kuhn, D.M., and Levine, R.A.: Influence of

Tetrahydrobiopterin on Serotonin Synthesis, Metabolism, and Release in Synaptosomes.

Neurochem. Int., 16: 335-340, 1990.

27. Citron, B.A., Milstien, S., Gutierrez, J.C., Levine, R.A., Yanak, B.L., and Kaufman, S.: Isolation

and Expression of Rat Liver Sepiapterin Reductase cDNA. Proc. Nat. Acad. Sci. 87: 6436-6440,

1990.

28. Park, Y.S., Heizmann, C.W., Wermuth, B., Levine, R.A., Steinerstauch, P., Guzman, J., and

Blau, N. Human carbonyl and aldose reductases: New catalytic functions in tetrahydrobiopterin

biosynthesis. Biochem. Biophys. Res. Comm., 175: 738-744, 1991.

29. Wolf, W.A., Zaija. E., Arthur, R.A. Jr., Anastasiadis, P.Z., Levine, R.A., and Kuhn, D.M. Effect

of tetrahydrobiopterin on serotonin synthesis, release, and metabolism in superfused hippocampal

slices. J. Neurochem., 57: 1191-1197, 1991.

30. Fleischhacker, W.W., Levine, R.A., Lieberman, J.A., Pollack, S., Johns, C.A., and Richardson,

M.A. Neopterin and biopterin CSF levels in tardive dyskinesia after clozapine treatment. Biol.

Psychiatry, 34:741-745, 1993.

31. Takahashi, H., Levine, R.A., Galloway, M.P., Snow, B.J., Calne, D.B., and Nygaard, T.G.

Biochemical and fluorodopa positron emission tomographic findings in an asymptomatic carrier

of the gene for DOPA-responsive dystonia. Ann. Neurol., 35: 354-6, 1994.

32. Nygaard, T.G., Waran, S.P., Levine, R.A., Naini, A.B., and Churtorian, A.M.: Dopa-responsive

dystonia simulating cerebral palsy. Pediatr. Neurol., 11: 236-40, 1994.

33. Anastasiadis, P.Z., Kuhn, D.M., and Levine, R.A.: Tetrahydrobiopterin uptake in rat brain

synapatosomes, cultured PC12 cells, and rat striatum. Brain Res., 665: 77-84, 1994.

34. Anastasiadis P.Z., Imerman B., Kuhn D.M., and Levine R.A.: Nitric oxide and catecholamine

synthesis: Involvement in tetrahydrobiopterin-mediated PC12 cell proliferation. Pteridines, 6 (3):

132-134, 1995.


43


35. Anastasiadis P.Z., Kuhn D.M., Blitz, J., Imerman, B.A., Louie, M.C., and Levine R.A.: Regulation

of tyrosine hydroxylase and tetrahydrobiopterin biosynthetic enzymes in PC12 cells by NGF, EGF

and IFN-. Brain Res., 713: 125-133, 1996.

36. Anastasiadis, P.Z., States, J.C., Imerman, B.A., Louie, M.C., Kuhn, D.M., and Levine, R.A.:

Mitogenic effects of tetrahydrobiopterin in PC12 cells. Mol. Pharmacol., 49: 149-155, 1996.

37. Anastasiadis P.Z., Imerman B., Louie M.C., States J.C., Kuhn D.M., and Levine R.A.:

Tetrahydrobiopterin as a mediator of PC12 cell proliferation induced by EGF and NGF. European J. Neuosci. 9: 1831-1837, 1997.

38. Bezin, L., Nygaard, T.G., Neville, J.D., Shen, H., and Levine, R.A.: Reduced lymphoblast

neopterin detects GTP cyclohydrolase dysfunction in dopa-responsive dystonia. Neurology 50(4):

1021-1027, 1998.

39. Anastasiadis, P.Z., Imerman, B., Blitz, J., Flam, M., Kuhn, D.M., and Levine, R.A.: Vasoactive

intestinal peptide induces both tyrosine hydroxylase and BH4 biosynthesis in PC12 cells.

Neuroscience 86: 179-189, 1998.

40. Groc, L., Levine, R.A., Foster, J.A., Normile, H.J., Weissmann, D., and Bezin, L.: Evidence of

deprenyl-insensitive apoptosis of nigral dopamine neurons during development. Brain Res. Dev.

Brain Res. 120: 95-98, 1999.

41. Anastasiadis, P.Z., Bezin, L., Imerman, B., Blitz, J., Kuhn, D.M., and Levine, R.A.:

Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support.

J. Biol. Chem. 276: 9050-9058, 2001.

42. Groc, L., Bezin, L., Foster, J.A., Jiang, H., Jackson, T.S., Weissmann, D., and Levine, R.A.:

Lipid peroxidation-mediated oxidative stress and dopamine neuronal apoptosis in the substantia

nigra during development. Neurochem. Int. 39(2): 127-133, 2001.

43. Groc, L., Bezin, L., Jiang, H., Hunter, T.S., Weissmann, D., Levine, R.A.: Bax, bcl-2, cyclin

expression, and apoptosis in rat substantia nigra during development. Neurosci. Let. 306(3): 198-

202, 2001.

44. Groc L., Jackson T., Jiang H., Bezin L., Koubi D., Corcoran G., and Levine R.A. Nitric oxide

synthase inhibition during development: effect on apoptotic death of dopamine neurons. Dev.

Brain Res. 138: 147-153, 2002.

45. Foster, J.A., P.L. Christopherson, and R.A. Levine. GTP cyclohydrolase I induction in striatal

astrocytes following intrastriatal kainic acid lesion. J. Chem. Neuroanat., 24: 173-179, 2002.


44


46. Foster, J.A., Bezin, L., Groc, L., Christopherson, P.L., and Levine, R.A.: Kainic acid lesion-

induced nigral neuronal death. J. Chem. Neuroanat., 26: 65-73, 2003.

47. Groc L, Hunter T, Jiang H, Bezin L, Levine RA: Developmental cell death and oxidative stress:

lessons from nigral dopamine neurons, Annals of New York Academy of Science 991: 307-310,

2003.

48. Tabakman, R., Jiang, H., Levine, R.A. , Kohen, R., and Lazarovici, P.: Apoptotic characteristics

of cell death and the neuroprotective effect of homocarnosine on pheochromocytoma PC12 cells

exposed to ischemia. J. Neurosci. Res. 75: 499-507, 2004

49. Tabakman, R., Jiang, H, Schaefer, E., Levine, R.A., and Lazarovici, P.: Nerve growth factor

(NGF) pretreatment attenuetes oxygen-glucose-deprivation induced c-Jun NH2-terminal kinase 1

and stress activated kinases p-38 alpha and p-38 beta activation and confers neuroprotection in

the pheochromocytoma PC12 model. J. Mol. Neurosci. 22: 237-250, 2004.

50. Koubi D, Jiang H, Zhang LJ, Tang W, Kuo J, Rodriguez AI, Hunter T, Seidman MD, Corcoran

GB, Levine RA (2004) Role of the Bcl-2 family of proteins in mediating apoptotic death of PC12

cells exposed to oxygen and glucose deprivation, Neurochem. Int. 46:73-81, 2005.

51. Jiang, H, Koubi, D, Zhang, L, Kuo, J, Rodriguez, AI, Jackson Hunter, T, Gautam, SC, and

Levine, RA: Inhibitors of iNOS protects PC12 cells against the apoptosis induced by oxygen and

glucose deprivation. Neurosci. Let. 375: 59-63, 2005.

52. Jiang, H, Zhang, L, Koubi, D, Kuo, J, Groc, L, Rodriguez, AI, Jackson-Hunter, T, Tang, S,

Lazarovici, P, Gautam, SC, and Levine, RA. Roles of Ras-Erk in apoptosis of PC12 cells induced

by trophic factor withdrawal or oxidative stress, J. Mol. Neurosci. 25:133-40, 2005.

53. Jiang H, Zhang LJ, Kuo J, Kuo K, Groc L, Rodriguez AI, Koubi D, Hunter T, Corcoran GB,

Seidman MD, Gautam SC, Levine RA. Resvetratrol-induced apoptotic cell death in human U251

glioma cells. Mol. Cancer Therapeutics 4:554-61, 2005.

54. Angoa-Pérez M, Jiang H, Rodríguez AI, Lemini-Guzmán C, Levine RA, and Rivas-Arancibia S.

Estrogen treatment counteracts the oxidative stress and loss of dopamine neurons in rat substantia

nigra produced by chronic ozone inhalation. NeuroReport, 17: 629-633, 2006.

55. Levine, RA: Hypnotherapy for the Treatment of Gastroesophageal Reflux Disease, Alternative and

Complementary Therapies. 15(1): 37, 2009.

56. Levine RA, St. John P, Mitsias P, Eckert E, Rau BJA, Conrad K, Ball, RM, Peterson EL, and

Rodriguez, AI. Integrative Neurosomatic Therapy Reduces Symptoms of Intractable Chronic

Headaches, Headache, to be submitted.


45


57. Rodriguez AI, Ball RM, Peterson E, Cogan CM, Ball RM, and Levine RA. Tracking Health

Outcomes of Complementary and Alternative Medicine Treatments in an Integrative Medicine

Center, BMC Complementary and Alternative Medicine Journal, to be submitted.

58. Levine RA, Rodriguez AI, Nunez R, Anderson K, Collon DJ, Rapp J, and Seidman MD. Hypnosis

and Acupuncture as the Primary Modes of Anesthesia during Anterior Cruciate Ligament

Reconstruction Surgery (in preparation).

59. Levine RA, Rodriguez AI, Nunez R, Ball RM, Mandel SS, Jackson-Schulte O, Peterson EL, and

Seidman MD. A Multimodal Complementary and Alternative Medicine Approach is More

Effective than Conventional Physical Therapy for Eliminating Chronic Back Pain: A Randomized

Controlled Trial (in preparation).

60. Levine RA, Nunez R, Ball RM, Peterson EL, and Rodriguez AI. Reducing and Eliminating

Chronic Back Pain using a Hands-Off Group Intervention with Complementary and Alternative

Medicine Therapies: A Randomized Controlled Trial in the Corporate Workplace (in preparation).

61. Walker EM, Rodriguez AI, Kohn B, Ball RM, Pegg J, Pocock JR, Nunez R, Peterson E, Jakary S,

& Levine RA. Acupuncture versus Venlafaxine for the Management of Vasomotor Symptoms in

Hormone Positive Breast Cancer Patients: A Randomized Controlled Trial, Journal of Clinical

Oncology, 28: 634-640, 2010.


46

BOOK CHAPTERS:

1. Eisler, T., Calne, D.B., Ebert, M.H., Kopin, I.J., Ziegler, M.G. and Levine, R.A.: Biochemical

measurements during (-)deprenyl treatment of Parkinsonism. In: MAO Structure, Function, and

Altered Function, Murphy, D., Singer, T., and Vonkoff, R. (Eds.), New York, Academic Press,

1979, pp. 497-506.

2. Lovenberg, W., Alphs, L., Pradhan, S., Bruckwick, E. and Levine, R.A.: Long-term haloperidol

and factors affecting the activity of striatal tyrosine hydroxylase. In: Advances in Biochemistry

and Psychopharmacology, Racagni, G., Spano, O. and Catabeni, F. (Eds.), Raven Press, New

York, pp. 9-15, 1980.

3. Levine, R.A., Kuhn, D.M., Williams, A.C. and Lovenberg, W.: The influence of aging on

biogenic amine synthesis: The role of the hydroxylase cofactor. In: Influence of Age on the

Pharmacology of Psychoactive Drugs, Raskin, A., Robinson, D.S. and Levine, J. (Eds.), Elsevier,

New York, pp. 37-46, 1981.

4. Levine, R.A., Lovenberg, W., Niederwieser, A., Leimbacher, W., Redwick, U., Staudenmann,

W., and Curtius, H.-Ch.: Penetration of reduced pterins into rat brain: Effect on biogenic amine

synthesis. In: Chemistry and Biology of Pteridines, Blair, J.A. (Ed.), Walter de Gruyter, Berlin,

New York, pp. 176-182, 1983.

5. Levine, R.A., Lovenberg, W., Curtius, H-Ch., and Niederwieser, A.: Speculation on the

mechanism of therapeutic action of tetrahydrobiopterin in human disease. In: Chemistry and

Biology of Pteridines, Blair, J.A. (Ed.), Walter de Gruyter, Berlin, New York, pp. 833-837, 1983.

6. Curtius, H.-Ch., Hausermann, M., Heintel, D., Niederwieser, A., and Levine, R.A.: Perspectives

on tetrahydrobiopterin biosynthesis in mammals. In: Chemistry and Biology of Pteridines, Blair,

J.A. (Ed.), Walter de Gruyter, Berlin, New York, 1983.

7. Lovenberg, W., Levine, R.A., Aiken, M.A., Miller, L.P. and LeWitt, P.: Regulation of biogenic

amine synthesis by the hydroxylase cofactor and its relation to aging and parkinsonism. In:

Intervention in the Aging Process, Part A, Regelson, W. and Sinex, F.M. (Eds.), Alan R. Liss,

Inc., New York, pp. 215-224, 1983.

8. Levine, R.A., Heintel, D., Leimbacher, W., Niederwieser, A., Curtius, H.-Ch., and Ghisla, S.:

Recent advances in tetrahydrobiopterin biosynthesis and the treatment of human disease. In:

Biochemical and Clinical Aspects of Pteridines, Vol. 2, Wachter, H., Curtius, H.-Ch., and

Pfleiderer, W. (Eds.), Walter de Gruyter, Berlin and New York, pp. 325-337, 1983.

9. Levine, R.A., Zoephel, G.P., Niederwieser, A. and Curtius, H.-Ch.: Tetrahydrobiopterin

analogues and their ability to enter the rat striatum after peripheral administration. In:

Biochemical and Clinical Aspects of Pteridines, Vol. 4, Wachter, H., Curtius, H.-Ch., and

Pfleiderer, W. (Eds,), Walter de Gruyter, Berlin and New York, pp. 267-276, 1985.


47

BOOK CHAPTERS (continued):

10. Levine, R.A. and Kelner, K.L.: Tetrahydrobiopterin and the regulation of catecholamine

synthesis in bovine adrenal medullary chromaffin cells. In: Chemistry and Biology of Pteridines,

B.A. Cooper and V.W. Whitehead (Eds.), Walter de Gruyter, Berlin, New York, pp. 373-76,

1986.

11. Galloway, M.P. and Levine, R.A.: Modulation of dopamine synthesis by nerve terminal

autoreceptors: A role for tetrahydrobiopterin? In: Chemistry and Biology of Pteridines, B.A.

Cooper and V.W. Whitehead (Eds.), Walter de Gruyter, Berlin, New York, pp. 347-50, 1986.

12. Levine, R.A. and Galloway, M.P.: The regulation of biogenic amine synthesis and role of

tetrahydrobiopterin. In: Unconjugated Pterins in Neurobiology: Basic and Clinical Aspects, W.

Lovenberg and R.A. Levine (eds.), Taylor and Francis, London, New York, pp. 119-130, 1987.

13. Levine, R.A.: Tetrahydrobiopterin and biogenic amine metabolism in neuropsychiatry,

immunology, and aging. In: Neuroimmunomodulation: Interventions in aging and cancer - First

Stromboli Conference on Aging and Cancer. W. Pierpoali, N.H. Specter, and B. Jankovic.

Annals of New York Academy of Sciences, pp. 129-139, 1987.

14. Levine, R.A., Wolf, W.A., Anastasiadis, P.Z., and Kuhn, D.M.: Effects of tetrahydrobiopterin on

the synthesis of serotonin in brain slices and synaptosomes: Implications for the use of BH4 as a

therapeutic agent. In: Chemistry and Biology of Pteridines, H.-Ch. Curtius and N. Blau (Eds.),

Walter de Gruyter, Berlin, New York, pp. 497-504, 1989.

15. Anastasiadis, P.Z., Wolf, W.A., Levine, R.A., and Kuhn, D.M.: Studies of tetrahydrobiopterin

uptake in rat brain synaptosomes. In: Chemistry and Biology of Pteridines, H.-Ch. Curtius and N.

Blau (Eds.), Walter de Gruyter, Berlin, New York, pp. 648-651, 1989.

16. Levine, R.A., Solus, J.F., Goustin, A.S., Tait, S., Demetriou, S., Citron, B., and Kaufman, S.:

Isolation of a putative cDNA encoding human brain sepiapterin reductase. In: Pterins and

Biogenic Amines in Neurology, Pediatrics, and Immunology, N.Blau, H.-Ch. Curtius, R.A.

Levine, and R.G.H. Cotton (Eds.), Lakeshore Publishing, pp. 81-88, 1991.

17. Anastasiadis, P.Z., Wolf, W.A., Kuhn, D.M., and Levine, R.A.: Sudies on the mechanism of

cellular tetrahydrobiopterin uptake. In: Pteridines and Related Biogenic Amines and Folates-

1992, N. Blau, H.-Ch. Curtius, R.A. Levine, and J. Yim (Eds.), Hanrim Publishing, Korea, pp.

116-122, 1992.

18. Levine, R.A., States, J.C., Anastasiadis, P.Z., and Kuhn, D.M.: Cloning and characterization of

genes encoding tetrahydrobiopterin biosynthetic enzymes. In: Chemistry and Biology of

Pteridines and Folates, J.E. Ayling, M.G. Nair, and C.M. Baugh (Eds.), Plenum Press, New York,

pp. 139-145, 1993


48

BOOK CHAPTERS (continued):

19. Anastasiadis, P.Z., States, J.C., Kuhn, D.M., and Levine, R.A.: Co-induction of

tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells. In:

Chemistry and Biology of Pteridines and Folates, J.E. Ayling, M.G. Nair, and C.M. Baugh (Eds.),

Plenum Press, New York, pp. 227-230, 1993.

20. Bezin, L., Anastasiadis, P.Z., Corcoran, G.B., Nygaard, T.G., and Levine, R.A.:

Tetrahydrobiopterin Metabolism in Cell Death by Apoptosis. In: Chemistry and Biology of

Pteridines and Folates, H. Rokos and W. Pfleiderer (Eds.), Blackwell Publishers, Berlin, pp 747-

754, 1997.

21. Bezin, L., Nygaard, T.G., Anastasiadis, P.Z., and Levine, R.A.: Tetrahydrobiopterin metabolism

and GTP cyclohydrolase I mutations in L-dopa-responsive dystonia. In: Proceedings of the Third

International Dystonia Symposium, S. Fahn and C.D. Marsden (Eds.), (in press).

22. Groc L, Bezin L, Jiang H, Hunter

T, Foster JA, Levine RA: Inhibition of oxidative stress during

developmental cell death: Cellular and behavioral effects. In: Chemistry and Biology of

Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds), Kluwer

Academic Publishers, Boston/Dordrecht/London, pp399-404, 2002.

23. Jiang H, Koubi D, Groc L, Hunter T, Anastasisdis PZ, Rodriguez AI, Corcoran GB, Levine RA:

The role of tetrahydrobiopterin (BH4) in apoptosis of catecholamine (PC12) cells induced by

trophic factor withdrawal. In: Chemistry and Biology of Pteridines and Folates, S. Milstien, G.

Kapatos, R.A. Levine and B. Shane (Eds), Kluwer Academic Publishers,

Boston/Dordrecht/London, pp405-408, 2002.

24. Koubi D, Jiang H, Hunter T, Anastasisdis PZ, Rodriguez AI, Corcoran GB, Levine RA (2002)

The involvement of tetrahydrobiopterin in ischemia-induced apoptosis. In: Chemistry and

Biology of Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds),

Kluwer Academic Publishers, Boston/Dordrecht/London, pp409-413, 2002.

25. Foster JA, Levine RA: Tetrahyrdobiopterin (BH4)-medidated neuronal death following

intrastriatal kainic acid: implications for Parkinson's disease. In: Chemistry and Biology of

Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds), Kluwer

Academic Publishers, Boston/Dordrecht/London, pp393-397, 2002.

26. Koubi D, Jiang H, Hunter T, Rodriguez AI, Corcoran GB, Levine RA: Tetrahydrobiopterin

(BH4) mediates necrotic death of PC12 cells exposed to ischemia-like conditions. In: Pterins,

Folates, and Neurotransmitters in Molecular Medicine, SPS Verlagsgesellscraft mbH, Heilbronn,

Germany, pp. 35-40, 2003.

27. Levine, RA: Dr. Bob Levine on Health and Wellness. In: You Make a Difference, Babypie

Publishing, Waitsfield, VT, USA, pp. 79-87, 2012. (Amazon Best Seller)

ABSTRACTS: (full list provided on request)

curriculum vitae - corporate wellness resources · curriculum vitae name: robert a. levine, ph.d.,...

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