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Curriculum Vitae -- Bradley B. Keller, MD
1 Updated: June 19, 2019
BIOGRAPHY and CONTACT INFORMATION Bradley B. Keller, MD Mobile Phone: 412-478-6463 Email: [email protected] Academic Office and Laboratory: Clinical Practice Office* Cardiovascular Innovation Institute Novak Center for Children’s Health University of Louisville 411 Chestnut Street, 5th floor, Suite A 302 East Muhammad Ali Blvd, Room 407 Louisville, KY 40202 Louisville, KY 40202 Clinical Office Phone: 502-588-7450 Academic Office Phone: 502-852-2150 *and multiple outreach offices Clinical Research Office: Pediatric Clinical Research Unit, Norton Children’s Hospital 251 East Chestnut Street, N-97, Louisville, KY 40202 Office Phone: 502-629-5820 A. Education UNDERGRADUATE: Dates Institution and Location Degree Received Major Sept. 1977 – May 1981 University of Pennsylvania Bachelor of Arts (1981) Biology (genetics) Philadelphia, PA GRADUATE: Dates Institution and Location Degree Received Sept. 1981 – May 1985 Pennsylvania State University Doctor of Medicine (1985) College of Medicine, Hershey, PA POST GRADUATE: Dates Institution and Location Field of Training Program Director June 1985 – June 1988 Department of Pediatrics Pediatrics (1988) Dr. Frank Oski The Johns Hopkins Hospital Baltimore, MD July 1988 – June 1991 Department of Pediatrics Pediatric Cardiology Dr. Edward B. Clark University of Rochester School Fellowship (1991) of Medicine, Rochester, NY B. Academic Appointments Dates Name of Institution Rank/Title/Position July 1988 - June 1991 University of Rochester Instructor and Fellow, Pediatrics July 1988 - June 1992 University of Rochester Attending Pediatrician, Emergency Department July 1991 - November 1996 University of Rochester Assistant Professor, Department of Pediatrics October 1992 - July 1996 University of Rochester Assistant Professor, Department of Physiology May 1996 - July 1999 University of Rochester Director, Pediatric CV Specialized Center of Research December 1996 - June 1998 University of Rochester Associate Professor, Department of Pediatrics July 1998 - June 2000 University of Rochester Adjunct Associate Professor, Dept of Pediatrics Dates Name of Institution Rank/Title/Position July 1998 - July 2002 University of Kentucky Jennifer Gill Associate Professor, Dept. of Pediatrics, Chief, Division of Pediatric Cardiology
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May 1999 - March 2000 University of Kentucky Medical Director, Pediatric Subspecialty Clinic July 2001 - June 2002 University of Kentucky Associate Professor with Tenure, Dept of Pediatrics July 2002 – August 2002 University of Kentucky Professor with Tenure, Department of Pediatrics August 2002 – April 2009 University of Pittsburgh Professor, Department of Pediatrics (tenure) August 2002 – June 2006 University of Pittsburgh Chief, Division of Pediatric Cardiology August 2002 - April 2009 University of Pittsburgh Member, McGowan Institute for Regen. Medicine August 2002 - April 2009 University of Pittsburgh Senior Investigator, Magee-Womens Research Institute September 2003 – June 2009 University of Pittsburgh Graduate Faculty, Cell Biol. and Molecular Physiology July 2005 – June 2006 University of Pittsburgh Director, Pediatric Card. Fellowship Training Program July 2006 – April 2009 University of Pittsburgh Director, Pediatric Biomedical Innovative Technology January 2007 – April 2009 University of Pittsburgh Member, Standing Committee for Tenured Faculty
Promotion and Appointment January 2007 – April 2009 University of Pittsburgh Member, Institutional Review Board (IRB) Committee May 2007 – April 2009 University of Pittsburgh Professor (secondary appt.), Dept of Bioengineering June 2007 – April 2009 Children’s Hospital of Pittsburgh Member, Committee on Surgical Innovation (COSI) July 2007 – April 2009 University of Pittsburgh Member, Technology Transfer Committee May 2008 – present Carnegie Mellon University Adjunct Professor, Dept. of Biomedical Engineering May 2009 - present University of Louisville Professor, Department of Pediatrics (tenure), Division of Pediatric Cardiology May 2009 - June 2019 University of Louisville Kosair Charities Chair in Pediatric Heart Research May 2009 - present University of Louisville Chief, Pediatric Heart Research, Cardiovascular Innovation Institute July 2009 – present University of Louisville Professor (adjunct), Department of Bioengineering June 2010 – October 2018 University of Louisville Vice Chair for Research, Department of Pediatrics July 2010 – present University of Louisville Professor (joint), Dept of Pharmacology & Toxicology July 2010 – present University of Louisville co-Director, UofL China Pediatric Research Exchange July 2014 – September 2018 University of Louisville Physician Lead, Design and Construction, New Novak Center for Children’s Health Jan 2017 - present University of Louisville Founder and Physician Lead, Arts Integration in Healthcare Program, Novak Center for Children’s Health April 2017 - present University of Louisville Director, Cardiology Outreach, Dept. of Pediatrics Sept 2013 – present Jiangxi Children’s Hospital Endowed Visiting Professor of Pediatrics C. Other positions and Employment including Military Service. None. D. Board Certification and Licensure MEDICAL LICENSURE: Licensing Board/State License Number Year National Board of Medical Examiners 308742 1986 Maryland D35795 1987 New York 174593 1988 Kentucky 34628 1999, re-activated 2009 Pennsylvania MD420075 2002 Federal Drug Enforcement Agency on request 1992, 2002 China and Tibet Autonomous Region temporary 2005, 2007, 2009, 2010 Indiana 01079246A 2017 (exp 10/31/19) SPECIALTY CERTIFICATION: Certifying Board Certificate Number Year Pediatrics #211796 40435 1989, 2001 Pediatric Cardiology #211796 954 1991, 2001, 2007, 2017
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E. Professional Society Boards and Activities Organization Years Rochester Community I.P.A., Inc., Cardiology Subcommittee 1996 - 1998 American Heart Association New York State Affiliate 1993 - 1998 Research Committee, Vice Chair 1994 - 1996 Chair, Grant Peer Review II 1995 - 1997 Executive Committee 1996 - 1998 American Heart Association, Genesee Board of Directors 1994 - 1998 Nominating Committee 1996 - 1998 Executive Board, Secretary 1996 - 1998 American Heart Association Mid-Atlantic Region 2003 - 2007 Research Peer Review, Cardiovascular Development and Basic Science Co-chair, CV Development and Basic Science Review Panel 2005 - 2007 American Heart Association, National Basic Science Research Committee Member 2009 - 2013 Research Outcomes Taskforce 2010 - 2013 F. Honors and Awards Title of Award Year Rotary International Foundation Educational Award 1979 - 1980 Magna cum laude, University of Pennsylvania 1981 Phi Beta Kappa, University of Pennsylvania 1981 University of Miami Medical Student Research Forum, First Place, Poster 1985 Fellow's Medical Student Teaching Award 1988 University of Rochester Class of 1988 World Forum Research Finalist 1993 1993 World Congress of Pediatric Cardiology and Cardiac Surgery Chairman’s Award for Pediatric Research 2001 Department of Pediatrics, Univ. of Kentucky Tenure, Excellence in Research, University of Kentucky 2001 Tenure, Excellence in Research, University of Pittsburgh 2002 Patient Satisfaction Award: Outstanding Achievement in Patient Care Children’s Hospital of Pittsburgh top 25 physicians 2004, 2005 Children’s Hospital of Pittsburgh top 10 physicians 2006 National Patient Satisfaction Award 2007, 2008 Tenure, Excellence in Research, University of Louisville 2009 Kosair Charities Chair in Pediatric Heart Research 2009 Admiral, The Great Navy of the State of Nebraska 2013 Frontiers in Physiology, Striated Muscle Physiology, Editorial Board 2013 - present Journal of Cardiovascular Development and Disease, Editorial Board 2013 - present RESEARCH FELLOWSHIP TRAINING AWARDS NIH NHLBI NRSA Post-Doctoral Fellowship #F32-HL07824. 07/01/1998 - 06/31/1990 Ventricular Mechanics in the Developing Chick Heart. (E.B. Clark, sponsor, K. Sagawa, advisor). UNIVERSITY OF ROCHESTER 07/01/1989 - 06/31/1990 Bradford Pediatric Fellow NIH NHLBI PSA Physician-Scientist Training Award #K11-HL02498. 07/01/1990 - 06/31/1995 Ventricular Mechanics in the Chick Embryo.
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G. Committee Assignments and Administrative Services
DEPARTMENT, HOSPITAL, AND UNIVERSITY COMMITTEES
UNIVERSITY OF ROCHESTER Strong Memorial Hospital Medical Records Committee 07/01/93 - 06/31/98 Policy Revision Subcommittee 07/01/96 - 06/31/98 Children's Hospital at Strong Faculty Liaison, Fundraising 07/01/94 - 06/31/98 UNIVERSITY OF KENTUCKY Executive Committee Department of Pediatrics 07/01/98 - 07/31/02 Pediatric Clinic Management Group Department of Pediatrics 07/01/99 - 06/31/00 Children’s Services Committee Children’s Hospital 07/01/98 - 06/31/00 Business Process Improvement “A” Chandler Medical Center 07/01/99 - 07/31/02 Steering Committee Gill Heart Institute 07/01/98 - 06/31/99 Faculty Recruitment Committee Department of Biochemistry 07/01/98 - 02/01/99 CHILDRENS HOSPITAL OF PITTSBURGH Division Chiefs Committee Department of Pediatrics 08/01/02 - 06/30/06 New Research Campus Design and Children's Hospital of Pittsburgh 10/01/02 - 06/30/06 Programming Committees and New CHP Hospital Design Director, Summer Student Research Program Children's Hospital of Pittsburgh 02/01/03 - 01/31/08 Faculty Incentive Plan Committee Department of Pediatrics 04/01/03 - 06/31/04 Medical Executive Committee Children's Hospital of Pittsburgh 07/01/03 - 07/01/06 Credentialing Committee Children’s Hospital of Pittsburgh 08/01/05 - 04/30/09 Innovative Surgical Technology Committee Children’s Hospital of Pittsburgh 06/01/07 - 04/30/09 Medical Staff Bylaws Committee Children’s Hospital of Pittsburgh 12/13/07 - 04/30/09 UNIVERSITY OF PITTSBURGH Human Investigational Review Board (appointed) 01/01/07 - 04/30/09 Standing Committee for Tenured Faculty Promotion and Appointment (elected) 01/01/07 - 04/30/09 Technology Transfer Committee (appointed) 07/01/07 - 04/30/09 UNIVERSITY OF LOUISVILLE Cardiovascular Innovation Institute, Director, Kosair Charities Pediatric Research Program 05/01/09 - present Dept. of Pediatrics Committee for Tenured Faculty Promotion, Appointment, and Tenure 05/01/09 - present Dept. of Pediatrics, KCHRI Director Search Committee 07/01/09 - 12/01/12 Univ. of Louisville, Faculty Senate, School of Medicine Representative 09/01/09 - 07/31/18 Univ. of Louisville, School of Dentistry, 5 year Chair Review Committee 01/10/10 - 06/30/10 Univ. of Louisville, Executive Vice President for Health Affairs Search Committee 07/01/10 - 07/01/11 Dept. of Pediatrics, Operational Leadership Committee 07/10/10 – 03/18/13 Dept. of Pediatrics, New Ambulatory Building Planning Committee 09/01/10 – 07/01/12 University of Louisville, Academic-Industry Taskforce 08/01/12 – 12/01/12 University of Louisville, School of Medicine Research Strategic Taskforce 01/01/13 – 08/01/13 Dept. of Pediatrics, Executive Committee (new, now suspended) 03/19/13 – 07/01/15 Dept. of Pediatrics, Community Advisory Committee (new) 07/01/14 - 07/01/17 Dept. of Pediatrics, new Novak Center for Children’s Health – Lead Physician 12/15/14 – 09/05/18 Univ. of Louisville, Dept of Biochem and Mol Biol, 5 year Chair Review Committee 07/10/16 – 09/15/16 NORTON CHILDREN’S HOSPITAL* (name change on 11/1/16 from Kosair Children’s Hospital) Kosair Children’s Hospital (now NCH), Cardiovascular Care Committee 09/01/09 - present Kosair Children’s Hospital (now NCH), Outreach Committee 09/01/10 - 07/01/12 Kosair Children’s Hospital (now NCH), Medical Executive Committee 01/05/11- 06/01/13 Kosair Children’s Hospital (now NCH), Academic Excellence Committee Co-Chair 04/01/11 – 07/01/12 Kosair Children’s Hospital (now NCH), Physician Workforce Committee 04/01/11 – 07/01/12
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H. Journal Editorial Boards, Advisory Councils, Peer Reviewer of Manuscripts PARTICIPATION IN PEER REVIEW OF SCIENTIFIC PUBLICATIONS American J. Physiology Anatomical Record Archives of Peds and Adol Med Basic Research Cardiology Birth Defects Research Cardiovascular Research Circulation Research Current Opinion in Cardiol. Developmental Dynamics Diabetes Institute for LabAnimal Res (NAS) J Biomech Engineering J Clinical Investigation J Experimental Biology J Mol Cell Cardiology Pediatric Cardiology Pediatrics International Pediatric Research Pediatric Transplantation Physiological Genomics Teratology Tissue Engineering Trends in Pharmacol Science J Cardiac Failure Circulation Scientific Reports (Nature publ). Microscopy & Microanalysis Telemedicine and E Health Experimental and Therapeutic Medicine Acta Biomaterialia Biotechnology and BioEng Frontiers in Physiology, Striated Muscle Physiology, Editorial Board 4/25/13 - present Journal of Cardiovascular Development and Disease, Editorial Board 7/19/13 - present PARTICIPATION IN STATE, NATIONAL, AND INTERNATIONAL RESEARCH PROPOSAL PEER REVIEW Panel participant Special Emphasis Panel on Research Priorities for Special Centers of Research in Pediatric Cardiovascular Diseases, Philadelphia, 1996. Panel participant NIH Special Emphasis Panel to develop priorities for the NHLBI SCOR awards in Pediatric Cardiovascular Diseases, Bethesda, 1997. Panel participant NIH Special Emphasis Panel to review grant applications for Specialized Centers of Research in Pediatric Cardiovascular Diseases, Bethesda, 1998. Panel participant NIH Special Emphasis Panel to review grant applications for heart failure RFA HL-97-012. Panel participant NIH Special Emphasis Panel on Saturation Mutagenesis and Murine Cardiovascular Phenotyping. Denver, CO, November 1998. Panel participant NIH Special Emphasis Panel to review Pediatric SCOR applications, NHLBI, January 2001. Panel participant NIH NHLBI CV-A study section, Bethesda, MD, February 2001. Panel participant NIH Special Emphasis Panel on Bioengineering Research Partnerships Bethesda, MD, April, 2001. Panel participant American Heart Association Mid-Atlantic Study Section 6, grant review member, Bethesda, MD April, 2004. Session co-chairman American Heart Association Mid-Atlantic Study Section 6 grant review, Bethesda, MD, March 2005 Panel participant NIH Special Emphasis Panel for PO1 applications on Novel Cardiovascular Genes, Bethesda, 2005 Session chairman American Heart Association Mid-Atlantic Study Section 6 grant review, Bethesda, MD, April 2006, April 2007 Panel participant NIH Special Emphasis Panel for PO1 applications on Novel Cardiovascular Genes, Bethesda, 2006 Panel participant NIH Myocardial Ischemia and Metabolism Study Section – Ad Hoc Reviewer, Bethesda, June 2006 Panel participant NIH Special Emphasis Panel Review: Institutional NHLBI Training Programs, Bethesda, Nov. 2006 Baltimore, Nov. 2007, Baltimore June & Dec 2008, Standing Study Section Member, July 1, 2009
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STATE, NATIONAL, AND INTERNATIONAL RESEARCH PROPOSAL PEER REVIEW (continued) Panel participant NIH NHLBI IRG CDD Study Section Ad Hoc Reviewer, Bethesda, MD June & November 2007 Standing Study Section Member July 1, 2008 through June 30th, 2012. Ad hoc member Oct 2012, Ad hoc member Feb 2017 Panel participant NIH Special Emphasis Panel Review: R01 proposals from standing members of CDD IRG Internet Assisted Meeting. December 2016 Panel chair NIH Special Emphasis Panel for cardiac stem cell R01 applications, March 2008, Oct 2008 Panel participant NIH Special Emphasis Panel Review: Stem Cell Biology. Ad Hoc Reviewer, Washington, DC, October 2013, June 2014 Meeting Chair and reviewer NIH Special Emphasis Panel Review: Differentiation and Integration of Stem Cells (Embryonic and Induced-Pluripotent). Internet Assisted Meeting. June 2015 Panel participant NIH Special Emphasis Panel Review: Cardiovascular SBIR and STTR Proposals. Ad Hoc Reviewer, Bethesda, MD, July 2012; San Antonio, TX, June 2015; San Diego, CA, July 2017 Alexandria, VA, Nov 2018; TBD, March 2019 Meeting Chair and reviewer NIH Special Emphasis Panel Review: Cardiovascular SBIR and STTR Proposals.
Bethesda, MD, March 2013 (chair), June 2015 and 2016 (chair), Alexandria, VA, November 2018 (co-chair), March 2019 (co-chair), July 2019, November 2019
Panel participant NIH Center for Scientific Review, Applications Comparison Pilot, February 2015 Mail Reviewer NIH Director Transformative Research Awards, March 2015 PARTICIPATION IN REGIONAL, NATIONAL, AND INTERNATIONAL MEETINGS Panel participant Committee on New and Emerging Models in Biomedical and Behavioral Research, National Research Council, Washington, 1997. Panel participant NIH Working Group on “The role of cholesterol and lipids in embryonic development and congenital disease”, Nashville, 1998. Panel participant Hormonal Regulation of the Growth and Function of the Neonatal Heart. 73rd Scientific Sessions, American Heart Association, New Orleans, November, 2000. Panel participant NIH Working Group on “Future Directions for Research Funding in Cardiac Development”, St. Louis, June, 2000. ORGANIZATION ROLE IN REGIONAL, NATIONAL, AND INTERNATIONAL MEETINGS Session co-chairman The World Congress on Medical Physics and Biomedical Engineering, Kyoto, JAPAN, 1991. Session co-chairman American Physiology Society sponsored Scientific Symposium: Regulation, integration, adaption: a species approach, San Diego,1994. Session moderator NHLBI Weinstein Cardiac Morphogenesis and Development Meeting: Philadelphia, PA, 1996. Session co-chairman 2nd World Congress, Pediatric Cardiology and Cardiac Surgery, Honolulu, Hawaii, 1997. Session chairman Developmental changes in cardiac function. Muroran Institute of Technology, Japan, 1998. Session moderator Cardiovascular Physiology and Engineering. Weinstein Cardiovascular Development Conference, Vanderbilt University, Nashville, 1998
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ORGANIZATION ROLE IN REGIONAL, NATIONAL, AND INTERNATIONAL MEETINGS (continued) Session co-chairman Selection of Animal Models. 71st Scientific Sessions, American Heart Association, Dallas, November, 1998. Program organizer “Noonan Congenital Cardiovascular Symposium”, 10/8/99, Lexington, KY. 11 speakers, 80 participants. Session co-chairman Featured Research: Mouse Models of Cardiac Dysfunction.72nd Scientific Sessions, American Heart Association, Atlanta, November, 1999. Steering committee “International Symposium on the Developing Heart”, 5/18-20/2000, Prague, Czech Republic. 40 speakers, 300 participants. Session chairman Function and Metabolism of the Developing Heart. International Symposium on the Developing Heart. Czech Academy of Sciences, Prague, May 2000. Session moderator Roundtable in Comparative Developmental Physiology, Sponsored by NSF Inn on the River, Glen Rose, TX, June 2002. Session moderator Mechanics in Cardiac Development. 9th Weinstein Cardiovascular Development Conference, Boston, MA, May 2003 Steering committee “2004 McGowan Institute for Regenerative Medicine Retreat” 2/23-24/2004, Nemacolin Resort, 10 speakers, 150 participants. Steering committee “2005 McGowan Institute for Regenerative Medicine Retreat” 3/6-7/2005 Nemacolin Resort, 12 speakers, 170 participants. Program co-organizer “First Annual Symposium on Advances in Congenital Cardiovascular Care” 10/15/05 Renaissance Hotel, Pittsburgh, PA, 12 speakers, 75 participants Session chairman Biomechanics of Cardiovascular Development. 5th World Congress of Biomechanics. Munich, Germany, July 2006 Program Committee “Patient and Family Centered Care Workshop Series: The Innovators Conference”, 11/7/07, Pittsburgh, PA Session co-chairman Diastology in Congenital Heart Disease. 82nd Scientific Sessions, American Heart Association, Orlando, November, 2009. Session co-organizer Biomedical Optics Symposium (BiOS): Optical Methods for Developmental Biology,
Photonics West, International Society for Optics and Photonics, 2/2-7/13, San Francisco, CA International Advisory Takao Symposium: Congenital Heart Disease from Genes to Morphology. 6/14-15/2013, Committee, Session Chair Tokyo, Japan Session co-chairman Session VI. 13th Annual CDBC/COBRE Symposium “Cardiovascular Development”, Charleston, SC, August, 2017 International Advisory Takao Symposium: Congenital Heart Disease: Origins and Novel Therapies for Pulmonary Committee, Session Chair Hypertension. 11/6-8/2017, Matsue, Japan
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ACADEMIC ADVISORY ACTIVITIES May 2009 – January 2013 State of Nebraska Founding committee member, Nebraska Stem Cell Advisory Committee “Stem Cell Research Act, LB606” July 2009 – July 2012 University of North Texas Member, External Advisory Board, Development, Physiology, and Genetics Academic Cluster January 2010 –July 2010 University of Nebraska Medical Expanding Pediatric Cardiovascular Research Center, Children’s Medical Center COMMUNITY FOUNDATIONS Medical Research Advisory Committee The Pittsburgh Foundation 04/01/03 - 04/30/09 Proposal Reviewer Pittsburgh Life Sciences Greenhouse 02/02/05 - 04/30/09 Proposal Reviewer Pittsburgh Technology Council 02/02/05 - 04/30/09 INTERNATIONAL COMMUNITY SERVICE Medical Director Touching Hearts Program in Tibet 07/01/05 – 06/01/10 This program screened school children in the Tibet Autonomous Region, PRC for congenital heart disease and then provided cardiac catheterization, interventional closure of ASDs and PDAs in Lhasa, Tibet Autonomous Region, PRC and surgical referral to Pediatric Heart Centers in Beijing and ChengDu, China. Funded by SEAPC, Oakmont, PA, via community donations. More than 21,000 children screened for heart disease and 250 children successfully treated with interventional procedures or heart surgery. Program operations were suspended in 2010 due to non-renewal of our contract. Pediatric Cardiology Consultant Swinfen Charitable Trust 07/01/05 – present This program provides teleconsultative services to international, medically underserved communities.
I. Academic Society Memberships
Organization Year American Academy of Pediatrics, Fellow 1992 - present Society for Pediatric Research, Member 1994 – present American Heart Association, National 1990 - present Cardiovascular Disease in the Young Basic Science 1992 – present New York Academy of Science, Member 1996 - 2002 Kentucky Medical Association 1999 - present American Physiologic Society, Member 1999 - present American Association for the Advancement of Science, Member 1999 - present National Marfan Society 1999 - present International Society for Heart Research 2000 - present International Society for Adult Congenital Heart Disease 2000 - present Society for Southern Pediatric Research 2000 - present Heart Failure Society of America 2000 - present American Pediatric Society 2004 - present American Telemedicine Association 2008 – present
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J. Mentoring DOCTORAL THESIS COMMITTEES
Sandra Stekelenburg-de Vos 7/01 to 6/05 Hemodynamics and heart function in the venous clipped chick embryo. Dept. of Ob/Gyn. Erasmus Univ, the Netherlands Thomas R. Payne 7/02 to 6/06 Differential myocardial infarct repair with muscle derived stem cells. Dept. of Bioengineering. University of Pittsburgh Arielle Drummond 7/05 to 12/08 Simulation of the optimal insertion for a pediatric VAD Dept. of Bioengineering. Carnegie Mellon University Hsun-Hsien Chang 3/06 to 9/07 Cardiovascular magnetic resonance imaging of paramagnetic particles to detect cardiac rejection. Carnegie Mellon Univ. Ti Soon Park 6/06 to 12/08 Origin and fate of human hemangioblast stem cells. Dept. of Cell Biology and Physiology. Univ. of Pittsburgh Lorenzo Soletti 6/06 to 11/08 Development of a Stem Cell-Based Tissue Engineered Vascular Graft. Dept. of Bioengineering, University of Pittsburgh Lauren Drowley 6/07 to 6/09 Myocardial repair using muscle derived stem cells. Depts.of Orthopedics and Bioengineering. University of Pittsburgh John Stella 05/08 to 9/11 Tissue engineering approaches for pulmonary valve surrogates. Dept. of Bioengineering, Univ. of Pgh Yajuan Wang 05/08 to 12/11 Decision support for ventricular mechanical assist device Dept. of Bioengineering. Carnegie Mellon University William Kowalski 05/08 to 06/14 Embryonic aortic arch growth and remodeling investigated via computational fluid dynamics. Dept. of Bioengineering. Carnegie Mellon University Hiren Trada 07/10 to 12/14 Development of porous multiple electrode arrays (P-MEA) to quantify and accelerate engineered tissue maturation. Dept. of Electrical and Computer Engineering. University of Louisville Currently: junior faculty, Cal Poly, San Luis, Obispo Mai-Dung Nyugen 10/11 to 07/14 Cardiac cell culture model (CCCM) as a left ventricle Mimic for in-vitro cardiac tissue engineering Natia Qipshidze Kelm 08/13 to 07/15 Preservation of cardiovascular function using conjugated linoleic acid and nitrite following MI. Katherine DeVeau 07/13 to 5/17 Impact of Exercise Training on Cardiovascular Dysfunction in Rats with Spinal Cord Injury. Landon Tompkins, MS 08/18 to present Development of a Universal Pediatric Assist Device Platform Technology
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MASTERS THESIS COMMITTEES Marc Dwenger 09/14 to 6/17 Optical Pacing of Engineered Cardiac Tissues. Lubna Hindi 04/18 to 11/18 Cholesterol Metabolism Correction of CRISPR Edited FH iPSC-Derived Hepatocytes
SCHOLARLY PROJECT AND RESEARCH MENTOR COMMITTEES
Adeboyega Abdulkadir, MD 7/06 to 6/08 Relationship between Fetal Rat Hemodynamics, Periventricular Leukomalacia, and Chorioamnionitis Diego Mougillansky, MD 7/06 to 4/09 Novel Contrast Agent Approaches to Characterize Injured Myocardium. Evonne Krushansky, MD 7/07 to 4/09 Wireless Detection of Abnormal Cardiac Electrical Activity (PELEX-C) Stephanie Downs 10/07 to 5/10 Improved Detection of Rural Congenital Heart Disease: The Touching Hearts in Tibet Project
Junior Faculty K. Tobita, MD 7/02 to 5/09 Biomechanics of Embryonic CV Systems Currently: Assistant Professor, Dept. of Dev. Biol. University of Pittsburgh, Pittsburgh, PA C. Ralphe, MD 6/04 to 11/07 Maturation of Cardiomyocyte Mitochondrial Function Currently: Assistant Professor, Dept. of Pediatrics, Division Chief, Pediatric Cardiology, University of Wisconsin, Madison, WS I. Libman, MD, PhD 7/04 to 5/09 Relationship Between Type I Diabetes Mellitus, Obesity, and Cardiovascular Risk Factors Currently: Assistant Professor, Dept. of Pediatrics, University of Pittsburgh, Pittsburgh, PA
T. Yanowitz, MD 9/04 to 11/07 Relationship between Fetal Rat Hemodynamics, Periventricular Leukomalacia, and Chorioamnionitis Currently: Assistant Professor, Dept. of Pediatrics, University of Pittsburgh, Pittsburgh, PA K. Brothers, MD, PhD 7/13 to 7/15 Ethics of Genomic Research Currently: Assistant Professor, Dept. of Pediatrics, University of Louisville, Louisville, KY Marcia P. Cole, PhD 9/13 to 7/15 Role of mitochondrial function and conjugated linoleic acid (cLA) treatment following myocardial injury Currently: Assistant Professor, Dept. of Biochemistry and Mol Biol, University of Louisville, Louisville, KY
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Post-Doctoral Residents and Fellows F. Heller, MD 1/92 to 3/92 Ventricular Function During Altered Contractile State Currently: Assistant Professor, Dept. of Pediatrics, University of Connecticut, Hartford, CT J. Murillo-Gonzalez, M.D 9/92 to 11/92 Morphogenesis during Cardiac Looping, Universidad Complutense, Madrid, SPAIN Currently: Associate Professor, Dept. of Anat. and Emb, Universidad Complutense, Madrid, SPAIN P. Bowers, MD 12/92 to 6/95 Ventricular/vascular Coupling During Alterations in the Nitric Oxide Pathway Currently: Medical Director, Blue Cross/Blue Shield of Connecticut, Hartford, CT M. Yoshigi, MD 10/94 to 9/97 Arterial Hemodynamics in the Embryonic Circulation (Dept. of Ped Card, Tokyo Women's Medical Col) Currently: Assistant Professor, Dept of Pediatrics, University of Utah, Salt Lake City, UT M. Broekhuizen, MD 5/95 to 5/97 Ventricular Function Following Retinoic Acid Treatment in the Stage 21 Chick Embryo. (Univ. Leiden, the Netherlands) Currently: Clinical Practice, Leiden, the Netherlands S. Furukawa, MD 7/96 to 6/98 Murine Maternal/Embryonic Coupling During Cardiovascular Development. (Medical College, Miyazaki City, Japan) Currently: Assistant Professor, Department of Obstetrics and Gynecology, Miyazaki City, Japan K. Tobita, MD 7/97 to 7/02 Embryonic Ventricular Mechanics Following Cardiac Septation (Dept. of Ped Card, TWMC, Tokyo) Currently: Assistant Professor, Dept. of Dev. Biol., University of Pittsburgh, Pittsburgh PA E. Schroder, Ph.D. 12/97 to 8/02 Myocardial Mechanics During Cardiovascular Development. Currently: Assistant Professor, Dept. of Physiology, University of Kentucky, Lexington, KY R. Akiyama, Ph.D. 4/99 to 4/00 Numerical Analysis of Embryonic Blood Flow. Currently: Research Assistant Professor, Dept. of Engineering, Mururan University, Mururan, Japan L. Jeffries, MD 6/99 to 7/01 Outcome Assessment in Rural Adult Congenital Heart Disease. Currently: Assistant Professor and Director of Heart Failure and Transplantation, Dept. of Peds., Cincinnati Children’s Hospital, Cincinnati, OH S. Sharma, MD 1/03 to 7/05 Regulation of Cardiovascular Structure and Function by Oxygen Tension in Chick and Mouse Embryos Currently: Pediatric Cardiology Practice, University of Tennessee, Knoxville, TN
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Post-Doctoral Residents and Fellows (continued) J. Lucitti, Ph.D. 4/03 to 8/05 Physiology and Biomechanics of the Developing Vasculature and Ventriculo-Vascular Interactions Currently: Research Scientist, UNC, Chapel Hill, NC N. Momoi, MD 4/04 to 4/06 Rodent Models of Cardiovascular Maternal-Fetal Coupling Currently: Associate Professor, Dept. of Peds., Fukushima Medical University, Japan M. Saaloukeh, MD 10/04 to 6/06 Intrauterine Effects of Maternal Caffeine Exposure on
Murine Embryonic Growth and Hemodynamics Currently: Neonatology clinical practice M. Manole MD 10 /04 to 6/06 Effect of Prerminal Gasping During Anoxic Arrest on
Cardiac Function in Immature Rats Currently: Assistant Professor, Dept. of Emergency Med., University of Pittsburgh, Pittsburgh, PA
E. Krushansky, MD 9/07 to 5/09 Wireless Detection of Abnormal Cardiac Electrical Activity (PELEX-C) Currently: Pediatric Cardiology Faculty, Dept. of Peds., Children’s Hospital of Pittsburgh, Pittsburgh, PA K. Cross, MD 2/10 to 6/11 Comparative Effectiveness of Ultrasound-Guided Nerve Block Versus Conscious Sedation for Pediatric Orthopedic Injury Management Currently: Pediatric Emergency Medicine Faculty Dept. of Peds., University of Louisville.
R. Salimi, MD 12/10 to 7/12 Development of a Small Animal Model to Investigate Capillary Leak via Reconstituted Microvascular Networks. Currently: Faculty in Pediatric Critical Care, St. Vincent’s Hospital, Indianapolis, IN M. Peek, MD 07/11 to 06/14 Development and Validation of Home Telemedicine Supported Anticoagulation Management Currently: Pediatric Cardiology Practice, Akron, OH L. Krishnan, PhD 07/11 to 4/12 Regenerative Potential of Umbilical Cord Derived Mesenchymal Stem Cells in Pediatric CV Repair Currently: Post-doctoral Research Fellow. Emory University R. Ymalay, MD 07/11 to 7/13 High Resolution Imaging in Neonates using the Vevo2100: CNS and Renal Imaging Currently: Neonatology Practice, KCMC, Ashland, KY A. Le Blanc, PhD 08/11 to 12/11 Age-Related Differences in Stromal Vascular Fraction- Assisted Coronary Microvascular Repair Currently: Research Assistant Professor,
Dept. of Physiology, Louisville, KY
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Post-Doctoral Residents and Fellows (continued) R. Chowning, MD 01/13 to 11/14 Genomic Associations with Neonatal Congenital Heart Disease – Single Center Experience at Kosair Children’s Hospital Currently: Post-doctoral Neonatology Fellow. Emory University L. Morgan, MD 07/13 to 6/16 Development and Validation of Home Telemedicine Supported Anticoagulation Management Currently: Pediatric Cardiology Fellow, U. Minnesota H. Masumoto, MD, PhD 08/13 to 08/15 Generation of Linear Engineered Cardiac Tissues using human induced Pluripotent Stem Cells Currently: Research Assistant Professor, RIKEN Center for Developmental Biology, Kobe, Japan William Kowalski 01/14 to 06/17 Embryonic aortic arch growth and remodeling
investigated via computational fluid dynamics. Currently: Postdoctoral Fellow, Laboratory of Stem Cell and Neurovascular Biology, Genetics and Dev. Biology Center, NHLBI, NIH, Bethesda, MD
A. Keskey-Black, MD 07/14 to 7/17 Prevalence and Impact of Psychosocial Comorbidities Children and Adults with Congenital Heart Disease Currently: Pediatric Cardiology Fellow, Children’s Hospital of Pittsburgh of UPMC R. Grisham Schutt, MD 01/17 to present Prevalence and Impact of Psychosocial Comorbidities Children and Adults with Congenital Heart Disease Currently: Pediatric Resident, U of L School of Medicine, Louisville, KY H. Yu, MD 07/17 to present In vitro Engineered Cardiac Tissue Model of Cadmium Toxicity and Zing Countermeasures Currently: UofL-China Pediatric Research Exchange Student, Pediatric Research Institute and the CII, U of L School of Medicine, Louisville, KY Y. Kang, MD 04/18 to 03/19 Impact of Pulmonary Hypertension and Sulforaphane
on Right Ventricular Dysfunction Currently: Faculty, Department of Anesthesiology, Guangdong Provincial People’s Hospital, Guangzhou, China
J. Zhen, MD 07/18 to present In vitro Engineered Cardiac Tissue Model of Doxorubicin Induced Myocardial Dysfunction Currently: UofL-China Pediatric Research Exchange Student, Pediatric Research Institute and the CII, U of L School of Medicine, Louisville, KY X. Zhang, MD 01/17 to present Cardio-Oncology: in vitro and in vivo models. Currently: UofL-China Pediatric Research Exchange Student, Pediatric Research Institute and the CII, U of L School of Medicine, Louisville, KY
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Post-Doctoral Residents and Fellows (continued) G. Zhang, MD 03/19 to present Impact of Pulmonary Hypertension on Right Ventricular Dysfunction in Diabetic Murine Myocardium Currently: UofL-China Pediatric Research Exchange Student, Pediatric Research Institute and the CII, U of L School of Medicine, Louisville, KY J. Yu, MD 03/19 to present Impact of Diabetes on Right Ventricular Dysfunction
and Adaptation. Currently: UofL-China Pediatric Research Exchange Student, Pediatric Research Institute and the CII, U of L School of Medicine, Louisville, KY
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Pre-Doctoral Students D. Dalecki 2/89 to 5/91 Cardiac Effects of Lithotripsy and Pulsed Ultrasound Currently: Professor, Dept. of Biomed. Eng., University of Rochester, Rochester, NY K. Campbell 7/90 to 9/90 Atrial Function in the Stage 16 to 24 Chick. 7/91 to 9/91 Donald Shapiro Medical Student Research Award U of R Medical Student Research Fellowship V. Fruci 6/90 to 9/90 Epicardial Ventricular Strains in the Stage 18 Chick
Embryo N. Shafer 7/91 to 9/91 Morphometry of the Vitelline Arterial Tree. 7/92 to 9/92 Donald Shapiro Medical Student Research Award U of R Medical Student Research Fellowship D. Smith 9/91 to 12/91 Computer Image Reconstruction of the Vitelline Arterial Tree C. Berno 10/91 to 6/92 Ventricular Epicardial Strain Analysis in the Stage 14 to 24 Chick Embryo. H. Sun 11/91 to 4/95 Epicardial Strain Analysis During Normal Growth and Following Heart Rate Alterations. J. Cartmell 7/92 to 6/93 Epicardial Strain Analysis During Alterations in Heart Rate in the Stage 21 Chick. J. Racy 7/92 to 9/92 Ventricular/Vascular Coupling in Response to Isoproterenol and Supplemental Preload. K. O'Gara 7/92 to 9/92 Embryonic Ventricular Passive Length-Tension Relations in the Excised Embryonic Heart. 7/93 to 9/93 Ventricular/Vascular Coupling and EDRF mimetics. C. Casillas 7/92 to 6/93 Heart Rate Reserve During Primary Cardiovascular Morphogenesis. AHA Funded Student Fellowship M. Preston 9/92 to 12/92 Morphometry of the Stage 9 to 13 Embryonic Heart. N. Yip 7/93 to 9/93 Embryonic Ventricular Pressure-Volume Relations During Changes in Heart Rate and Loading Conditions. A. Chamis 7/93 to 9/93 3D Epicardial Strain Analysis of the Embryonic Heart. 7/94 to 9/94 Hui Li 7/93 to 5/94 Three-Dimensional Solid Geometric Modeling of the Embryonic Heart During Cardiac Looping. Y. Takagi 9/94 to 6/96 Accuracy Analysis of Three-Dimensional Epicardial Strains B. Koomer 1/95 to 6/95 Comparison of Video and Confocal Microscopic Estimates of Embryonic Ventricular Volume.
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Pre-Doctoral Students (continued) J. Ettel 9/95 to 9/96 Arterial Impedance During Alterations in Cycle Length. Epicardial Ventricular Strains Following Conotruncal Banding. N. Ursem 7/95 to 6/99 Quantification of Human Embryonic Blood Velocity Profiles in Normal and High-Risk Pregnancies. (Erasmus University, Rotterdam, the Netherlands) K. Babbitt 7/95 to 7/97 Capacitive Nanosensors for Pressure Measurements in the Embryonic Cardiovascular System. (RIT)
B. Zong 9/95 to 6/96 Electronic Signal Conditioning of Capacitive and Piezoelectric Nanosensors for the Embryonic Cardiovascular System. (RIT)
E. Schenck 9/95 to 6/96 Implantable Piezoelectric Telemetry Nanosensors for the Embryonic Cardiovascular System. (RIT) K. Mangold 6/96 to 8/96 Fetal Diagnosis and Therapy of Trisomy 21 With and Without Congenital Heart Disease. G. Neri 9/96 to 10/97 Microelectronic Design and Fabrication for Biological Material Testing. (RIT) E. Gilbert 6/97 to 8/97 Regional Myocardial Epicardial Strains Following Left- Atrial Ligation in the Chick Embryo. Currently: Pediatric Medical Practice, Philadelphia, PA J. Tabor 6/01 to 8/01 Effect of Maternal Hypoxia on Murine Embryonic Heart Function. J. Nonemaker 5/03 to 8/03 Impact of Mechanical Strain of Myofiber Alignment on Embryonic Cardiomyocytes Currently: Clinical Research Specialist, Hartford, CT C. Nordman 5/03 to 8/03 Relationship Between Hypoxia and Embryonic Chick Cardiovascular Function Currently: Chief Radiology Resident, University of Pittsburgh PGY4 R. Barnett 6/04 to 8/04 Regulation of Vascular Material Properties by Altered Biomechanical Load E. Chay 6/04 to 8/04 Contribution of Pacing Stimulation to Cardiomyocyte Maturation in Early Embryonic Engineered Cardiac Tissue M. Choi 9/04 to 8/05 Multimedia Presentation of Cardiovascular Research A. Drummond 7/05 to 11/08 Simulation of the optimal insertion for a pediatric VAD
“2008 African-American Bioengineering Student of the Year” Currently: Research Scientist
Kelly Clause 7/06 to 5/10 Biomechanics of Engineered Embryonic Cardiac
Tissues (funded by NIH T32 to S. Shroff)
Curriculum Vitae -- Bradley B. Keller, MD
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Pre-Doctoral Students (continued) Katie Thompson, Marita Mann, Wendy Kho 1/07 to 6/07 CMU Senior Biomechanics Design Project: Pulsatile Alyssa Haney, Daqian Wu Phantom for Vascular Access Training CMU Daniel Bernier, Huiyi Li, 1/07 to 6/07 CMU Senior Biomechanics Design Project: Implantable Rajit Patel, Sid Viswanathan Pediatric Cardiovascular Biosensor CMU
Lauren A. Paladino 6/07 to 8/07 Heart Rate, Oxygen Saturation, and Blood Pressure Response to Exercise in Children With Congenital Heart Disease at High Altitude in the Tibet, PRC Yajuan Wang 9/07 to 10/08 Vascular Imaging and Flow Modeling During Cardiovascular Morphogenesis 10/08 to 12/11 Decision Support Applied to Human Heart Failure Currently: Research Scientist, VAD Corporation Stephanie Downs 10/07 to 2/10 Improved Detection of Rural Congenital Heart Disease: The Touching Hearts in Tibet Project Currently: Surgical Resident, University of Pittsburgh School of Medicine, Pittsburgh, PA
Jennifer Stevens 06/08 to 10/08 Wireless Detection of Abnormal Cardiac Electrical Activity (PELEX-C) Currently: Medical Student, University of Pittsburgh School of Medicine, Pittsburgh, PA Onur Dur 09/07 to 07/10 Computational Fluid Dynamics and Numerical Modeling of Embryonic, Fetal, and Pediatric Blood Flow Relevant to Congenital Heart Disease. Currently: Staff Engineer, Thoratec, Inc. William J Kowalski 09/09 to 06/14 Embryonic aortic arch growth and remodeling investigated via computational fluid dynamics. Currently: Post-doctoral Scientist, Laboratory of Stem Cell and Neurovascular Biology, Genetics and Dev. Biology Center, NHLBI, NIH, Bethesda, MD Dan Kmetz 06/10 to 08/10 3D Confocal Image Analysis of Composite Engineered Tissues Composed of Embryonic Cardiac Cells and Microvascular Fragments Currently: Medical Student, University of Louisville Hiren Trada 07/10 to 12/14 Development of porous multiple electrode arrays (P-MEA) to quantify and accelerate engineered tissue maturation. Dept. of Electrical and Computer Engineering. University of Louisville Currently: Faculty, Dept. of Bioengineering, UC Alison Keskey-Black 01/11 to 06/14 Application of Home Telemonitoring to High-Risk Infants with Congenital Heart Disease Currently: Pediatric Cardiology Fellow, CHP Mai-Dung Nyugen 10/11 to 07/14 Cardiac cell culture model (CCCM) as a left ventricle Mimic for in-vitro cardiac tissue engineering Currently: pursuing post-doctoral positions
Curriculum Vitae -- Bradley B. Keller, MD
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Pre-Doctoral Students (continued) Vandra Harris 01/13 to 7/13 Application of High Resolution Ultrasound to Pediatrics Currently: ENT resident, Johns Hopkins Hospital Nicholas C. Allen 05/13 to 12/13 Extracellular Matrix Production from Chicken Cardiac Fibroblasts Under Different Culture Conditions Currently: Bioengineering undergraduate student, University of Louisville Katherine DeVeau 07/13 to 5/17 Impact of Exercise Training on Cardiovascular Dysfunction in Rats with Spinal Cord Injury. Currently: Assistant Professor, Dept of Anatomy George Washington University Takeichiro Nakane 08/14 to 08/16 Generation of Large Format Engineered Cardiac Tissues using human induced Pluripotent Stem Cells Currently: Research Assistant Professor, Kyoto University, Kyoto, Japan Marc Dwenger 09/14 to 5/17 Optical Pacing of Engineered Cardiac Tissues. Currently: Pharmacology and Toxicology doctoral student, University of Louisville. Shuji Setozaki 05/16 to 04/17 Generation of h-iPSC derived Engineered Cardiac Tissues using Human Compatible Reagents
Currently: Department of Cardiovascular Surgery, Okamura Memorial Hospital, Shimizu, Japan
Alison Wintring, M.Eng 01/16 to present Prevalence and Impact of Psychosocial Comorbidities Children and Adults with Congenital Heart Disease Currently: U of L Medical Student Lekha Devara 01/17 to present Prevalence and Impact of Psychosocial Comorbidities Children and Adults with Congenital Heart Disease Currently: U of L Undergraduate Student
Curriculum Vitae -- Bradley B. Keller, MD
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MEDICAL STUDENT, RESIDENT, and FELLOW EDUCATION General Pediatric Cardiology Teaching Rounds: Medical Students, Residents, and Fellows. Strong Memorial Hospital, Rochester, NY (avg. 2 hours per week) 1991 - 1998 University of Kentucky Children’s Hospital, Lexington, KY (avg. 2 hours per week) 1998 - 2002 Children’s Hospital of Pittsburgh, Pittsburgh, PA (avg. 2 hours per week) 2002 – 2009 Norton Children’s Hospital, Louisville, KY (avg. 2 hrs per week) 2009 - 2016 Outpatient Pediatric Cardiology Clinics, multiple locations (avg. 2 hrs per week) 2009 - present Pediatric Resident Noon Conferences: “General Pediatric Cardiology Topics” (2 course hours per year) CHP 2002 - 2009 “Challenges and Opportunities: Choosing the Physician-Scientist Career Path”. Exploring Academic and Subspecialty Careers Symposium, Ped Residents, UofL, (2 hrs/yr) 2010 - 2015. “Presentation and Management of Congenital Heart Lesions” 2015, 2018 Neonatology Seminar Series: Cardiovascular Development and Diseases, CHP (2 hrs/yr) 2003 - 2006 Medical School Lectures: “Genetics of Cardiovascular Disease: from Embryo to Adult” Univ. Pitt. (4 hrs/yr) 2002 - 2007 Molecular Regulation of Cardiovascular Development, Myocardial Hyperplasia and Hypertrophy. MSCMP 2730: Mol. Mechanisms of Tissue Growth and Adaptation. Univ. Pitt. (2 hrs/yr) 2006-2007 “Origins of CHD” Department of Pediatrics – MSIII Lecture. UofL. (1 hr/yr) 2009 - 2015 “Challenges and New Frontiers in Pediatric Cardiology. In: “Bench to Bedside: Introduction to
Clinical and Translational Research Lecture Series”.MSII Lecture - Clinical Translational Science Institute, UofL (1.5 hr/yr) 2010 - 2012
Bioengineering Lectures: “Insights from Embryos: How to Build and Mend the Heart.” Univ. of Pittsburgh. BioE 3600: Forces That Shape Organogenesis (2 hours / yr) 2006 - 2008 “eDesign for Cardiovascular Device Applications.” Carnegie Mellon University. (1 hrs / yr) 2006-09 “Surgery for Engineers: Congenital Heart Disease.” Carnegie Mellon University. (2 hrs / yr) 2006-09 Adult Cardiology Fellow Lectures: “Origins of CHD” Louisville, KY, (1.5 hrs/yr) 2009 – 2015 Department of Physiology: “Introduction to Cardiovascular Physiology from Embryos to Adults with Congenital Heart Disease as the Landscape”. University of Louisville, 1/12/16 2 hrs. Research Mentorship listed under trainees and training research funding.
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K. Abstracts and Presentations (partial listing)
1. Keller BB, Hu N, Zahka KG and Clark EB. Ventricular Pressure-Area Loops in the Stage 21 Chick Embryo. Circulation 1987;76(4):552.
2. Keller BB, Hu N, and Clark EB. Correlation of ventricular measurements with mass and function in the stage 12 to 24
chick embryo. Ped Res 1989;25:II-26A.
3. Hu N, Keller BB, and Clark EB. Relationship of cycle length, diastolic filling and ventricular performance in the stage 21 chick. Ped Res 1989;25:II-25A.
4. Hu N, Connuck D, Keller BB, and Clark EB. Diastolic ventricular function in stage 1 to 27 chick. Ped Res
1989;25(4):II-25A.
5. Keller BB, Hu N, Serrino PJ, and Clark EB. Pressure-area loop characteristics in the stage 18, 21, and 24 chick embryo. Circulation 1989;80(4):II-165.
6. Hu N, Connuck D, Keller BB, and Clark EB. Passive and active diastolic ventricular function in stage 12 to 27 chick
embryo. Circulation 1989;80(4):II-469.
7. Keller BB, Hu N, and Clark EB. Ventricular pressure-area loop characteristics during cardiac development in the chick embryo. In Abstracts of the First World Congress of Biomechanics. UCSD, San Diego, 1990;I:151.
8. Taber LA, Keller BB, and Clark EB. Experimental and theoretical strains in the developing chick heart. In Abstracts of
the First World Congress of Biomechanics. UCSD, San Diego, 1990;II:234.
9. Keller BB, Hu N, and Clark EB. Ventricular filling and ejection characteristics after conotruncal banding in the chick embryo. Circulation 1990;82(4)III-187.
10. Hu N, Keller BB, and Clark EB. Relationship of simultaneous atrial and ventricular pressures in the stage 16 to 27
chick embryo. Circulation 1990;82(4)III-491.
11. Hu N, Keller BB, Taber LA, and Clark EB. Diastolic wall modulus and ventricular stiffness in the stage 16 to 27 chick embryo. Circulation 1990;82(4)III-605.
12. Keller BB, Hu N, and Clark EB. Embryonic ventricular mechanics during early cardiac development resembles mature
pressure-volume relations. (the World Congress on Medical Physics and Biomedical Engineering, July 1991, Kyoto, JAPAN)
13. Keller BB, Hu N, and Clark EB. Cardiac mechanics in the developing heart during normal and accelerated ventricular
growth. Ped Res 1991;29:20A
14. Campbell KA, Keller BB, Hu N, and Clark EB. Analysis of dynamic atrial dimension and function during early cardiac development in the chick embryo. Ped Res 1991;29:15A.
15. Hu N, Keller BB, and Clark EB. The effect of bradycardia on systolic and diastolic time intervals in the stage 16 to 27
chick embryo. Ped Res 1991;29:19A.
16. Keller BB, Tinney JP, Hu N, and Clark EB. Ventricular end-diastolic and end-systolic relations in the embryonic chick heart. Circulation 1991;84(4)II-188.
17. Taber LA, Yang M, Keller BB, and Clark EB. A poroelastic model for the trabeculated embryonic heart. Adv. Bioeng (presented at 1991 ASME winter annual meeting).
18. Keller BB, Tinney JP, Hu N, and Clark EB. Embryonic ventricular pressure-volume mechanics. Ped Res 1992;31:235A.
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19. Hu N, Taber LA, Keller BB, and Clark EB. Maintenance of ventricular relaxation rate in the growth accelerated embryo heart in stage 21 to 29 chick. Ped Res 1992;31:19A.
20. Shafer NL, Smith DS, Babineau HP, Keller BB and Clark EB. Vitelline arterial dimensions during primary cardiovascular development. Ped Res 1992;31:23A.
21. Keller BB, Tinney JP, Hu N. Arterial elastance in the stage 16 to 21 chick embryo. Circulation 1992;86(4)I-205.
22. Hu N, Keller BB, Clark EB. Effect of chronic verapamil treatment on ventricular relaxation rate in stage 21 to 29 chick
embryo. Circulation 1992;86(4)I-843.
23. Casillas CB, Tinney JP, Clark EB, Keller BB. Heart rate reserve during cardiovascular morphogenesis. (presented at the Annual Conference of the Society for the Advancement of Chicanos and Native Americans in Science, Albuquerque, New Mexico)
24. Cartmell J, Taber LA, and Keller BB. Epicardial ventricular strains during tachycardia in the stage 21 chick embryo. J.
Univ Rochester Medical Center 1993;4:26.
25. Taber LA, Lin IE, and Keller. Growth and deformation during cardiac looping: Observations and hypotheses. proceedings of the 1993 ASME Bioengineering Conference, 1993;24:111-114.
26. Taber LA, Hu N, Murillo-Gonzales J, Clark EB, and Keller BB. Residual strain in the embryonic chick heart.
proceedings of the 1993 ASME Bioengineering Conference, 1993;24:115-118. 27. Keller BB, Tinney JP, and Hu N. Ventricular/vascular coupling in the stage 16 to 21 chick embryo. Ped Res
1993;33:22A.
28. Keller BB, Heller FA, and Tinney JP. Effect of isoproterenol induced vasodilation on ventricular pressure-volume relations in the stage 21 chick embryo. Ped Res 1993;33:248A.
29. Casillas CB, Tinney JP, Clark EB, and Keller BB. Heart rate reserve during cardiovascular morphogenesis. Ped Res
1993;33:245A.
30. Keller B, Tinney J, Hu N, and Clark E. Embryonic ventricular pressure-volume relations in the stage 16 to 21 chick embryo. Cardiology in the Young 1993;3:2.
31. Keller B, Murillo-Gonzalez J, Aguirra M, and Taber L. Geometric measures of the stage 9 to 14 embryonic chick heart:
relevance to hypotheses of growth and deformation during cardiac looping. Cardiology in the Young 1993;3:124.
32. Bowers P, Tinney JP, and Keller BB. Nitroprusside selectively reduces preload in the stage 21 chick embryo. Circulation 1993;88:I-148.
33. Hu N, Tinney JP, and Keller BB. Atrial pressure-volume loop characteristics in the stage 24 chick embryo. Ped Res
1994;35:36A.
34. Hu N, Hansen AL, Clark EB, and Keller BB.. Atrial natriuretic peptide reduces diastolic filling in the stage 21 chick embryo. Ped Res 1994;35:36A.
35. Taber LA, Lin IE, Hu N, Clark EB, and Keller BB. Residual stress in the developing heart. Southern Biomedical
Engineering Conference, April 1994.
36. Bowers PN, Tinney JP, and Keller BB. Embryonic ventricular response to preload reduction produced by nitric oxide or venous hemorrhage. (poster, AHA Scientific Conference on the Molecular, Cellular, and Functional Aspects of Cardiovascular Development, New Orleans, 3/95)
37. Hu N, MacLennan MJ, Yoshigi M, and Keller BB. Atrial ejection volume matches ventricular active filling volume in the stage 16 to 27 chick embryo. Ped Res 1995;37:27A.
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38. Hu N, MacLennan MJ, Tinney JP, and Keller BB. Atrial pressure-volume loop characteristics in the stage 16 to 27
chick embryo. Ped Res 1995;37:27A.
39. Yoshigi M, Hu N, and Keller BB. Flow dependence of arterial impedance in stage 24 chick embryos. Ped Res 1995;37:38A
40. Bowers PN, Tinney JP, and Keller BB. Endogenous nitric oxide from L-arginine reduces preload in stage 21 chick
embryos. Ped Res 1995;37:21A.
41. Keller BB, MacLennan MJ, Tinney JP, and Yoshigi M. In vivo assessment of murine embryonic cardiovascular function. FASEB J 1996;10:A581.
42. Hu N and Keller BB. Left atrial ligation alters intracardiac blood flow, cardiovascular growth, and function in the chick
embryo. FASEB J 1996;10:A312.
43. Tinney JP and Keller BB. Ventricular/vascular coupling and uncoupling in the embryonic cardiovascular system. FASEB J 1996;10:A580.
44. Yoshigi M and Keller BB. Frequency domain and time domain analysis of characteristic impedance in the embryonic
chick vasculature. FASEB J 1996;10:A564.
45. Keller BB. Pulsed-Doppler investigation of embryonic cardiovascular function: applications and limitations. Ultrasound Obst Gyn 1996;8:A57.
46. Keller BB, Miller CE, and Tsyvian P. Force-interval relationships and mechanical restitution in developing chick and
mouse myocardium. Circulation 1996;94:I120.
47. Keller BB, Hu N, Yoshigi M, Tsyvian P, and Miller CE. Future directions in the investigation of integrated embryonic cardiovascular physiology and mechanics. poster, 2nd World Congress, Ped Card and Cardiac Surg, Honolulu, Hawaii.
48. Yoshigi M and Keller BB: Developmental changes in wave reflection in the chick embryonic vasculature. platform talk,
2nd World Congress, Ped Card and Cardiac Surg, Honolulu, Hawaii.
49. Hu N, Smith BR, Lai CT, and Keller BB: Dependence of aortic arch morphogenesis on intra-cardiac blood flow in the chick embryo. FASEB J 1997;11:A16.
50. Keller BB, Miller CE, Tsyvian P, Routkevich S, and Protsenko Y: Force-interval relationships in developing chick
myocardium. Effect of ryanodine and hypercalcium solutions. (poster, 33rd International Congress of Physiological Sciences, IUPS 1997, St. Petersburg, Russia).
51. Keller BB, Hu N, Yoshigi M, Tsyvian P, and Miller CE: Investigations in embryonic cardiovascular development: in
vivo and in vitro models. 33rd International Congress of Physiological Sciences, IUPS 1997, St. Petersburg, Russia, July 1997.
52. Sedmera D, Rychterova V, Keller BB, and Hu N. Changes in the myoarchitecture of the left atrial-ligated heart in the
stage 34 chick embryo. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.
53. Hu N, Lai CT, McNeil EM, and Keller BB. Diastolic filling characteristics following ventricular septation in the left atrial ligated chick. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.
54. MacLennan MJ and Keller BB. Murine embryonic umbilical arterial velocity during development and following acute
increases in heart rate. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.
55. Furukawa S and Keller BB. Influence of pregnancy on systemic blood pressure in the anesthetized and conscious mouse. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.
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56. Yoshigi M and Keller BB. Pulsatile vascular hemodynamics in the developing chick embryo. poster, Weinstein
Cardiovascular Development Conference, Cincinnati, June 1997.
57. Mangold KA, Keller BB, and Truesdell SC: Prenatal diagnosis of Down syndrome and its impact on the prevalence and outcome of congenital heart disease. J Univ Rochester 1997;9:51.
58. Keller BB and MacLennan MJ. Murine embryonic umbilical arterial blood flow during development and following
acutely increased heart rate. Circulation 1997;96:I513.
59. Solovyeva O, Katsnelson L, Romanchenko T, Tsyvian P, Routkevich S, Markhasin V, and Keller BB. Mathematical modeling of active embryonic myocardium mechanics (1998 American Biophysical Society Annual Scientific Sessions).
60. Keller BB and MacLennan MJ. Cardiovascular phenotypic analysis of targeted mouse embryos. Human Genome
Applications to Cardiovascular Diseases, San Diego, CA, March, 1998.
61. MacLennan MJ, Tinney JP, and Keller BB: In situ measurement of ventricular blood pressure in the mouse embryo. FASEB J 1998;12:A323.
62. McNeil EM, Campbell K, Keller BB, and Hu N: Effect of increased circulating volume on diastolic filling in the stage
21 chick embryo. FASEB J 1998;12:A323.
63. Tinney JP and Keller BB: Ventricular function after chronic conotruncal banding in the chick embryo. FASEB J, 1998;12:A324.
64. Hu N, McNeil EM, Weiss KM, Baggs R, and Keller BB: Apoptosis of ventricular myocytes following left atrial ligation
in the stage 34 chick. FASEB J 1998;12:A710.
65. Furukawa S and Keller BB: Murine maternal-embryonic coupling during acute maternal hypoxia. FASEB J 1998;12:A998.
66. Tobita K and Keller BB: Average systolic myocardial stiffness is a load independent index of contractility in the
embryonic chick heart. Weinstein Cardiovascular Development Conference, Nashville, May 1998.
67. Tinney JP and Keller BB: Ventricular function after chronic conotruncal banding in the chick embryo. Weinstein Cardiovascular Development Conference, Nashville, May 1998.
68. Furukawa S and Keller BB: Murine maternal-embryonic coupling during acute maternal hypoxia. Weinstein
Cardiovascular Development Conference, Nashville, May 1998.
69. MacLennan MJ, Tinney JP, and Keller BB: In situ measurement of ventricular blood pressure in the mouse embryo. Weinstein Cardiovascular Development Conference, Nashville, May 1998.
70. Yoshigi M and Keller BB: Pulsatile energy expenditure in the embryonic arterial system. Third World Congress of
Biomechanics. Sapporo, JAPAN, August, 1998.
71. Keller BB: Function, biomechanics, and control of the developing cardiovascular system. The Fifth International Symposium on Etiology and Morphogenesis of Congenital Heart Disease, Tokyo, Japan, December, 1998.
72. Smith B, Lo CW, Keller BB, and Hu N: Magnetic resonance imaging and analysis of the embryonic and fetal heart.
The Fifth International Symposium on Etiology and Morphogenesis of Congenital Heart Disease, Tokyo, Japan, December, 1998.
73. Tobita K and Keller BB: Developmental change of end-systolic stress-strain relations in chick embryonic ventricle.
FASEB J 1999.
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74. Schroder EA, Tsyvian PB, and Keller BB: Force-velocity relations in the developing chick myocardium. FASEB J 1999.
75. Tobita K and Keller BB: Right and left ventricular epicardial strains in normal developing chick embryonic hearts.
Weinstein Cardiovascular Development Conference, Tucson, May 1999.
76. Tobita K and Keller BB: Developmental change in ventricular contractility determined from end-systolic stress-strain relations in the chick embryo. Weinstein Cardiovascular Development Conference, Tucson, May 1999.
77. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Force-frequency relationship in developing chick myocardium:
Effects of nickel and mibefradil. Weinstein Cardiovascular Development Conference, Tucson, May 1999.
78. Keller BB, EA, Satin J, Tsyvian PB, and Schroder EA: Sensitivity of force-interval relationships in developing chick myocardium to Ca2+ channel blockade. 2000 Biophysical Society Meeting, New Orleans, LA.
79. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Sensitivity of force-frequency relations in developing chick
myocardium to Ca channel blockade. J Mol Cell Cardiol 2000;32:A76.
80. Schroder EA and Keller BB: Effect of temperature on force-velocity relations in stage 24 embryonic chick myocardium. J Mol Cell Cardiol 2000;32:A77.
81. Tobita K and Keller BB: Epicardial strain patterns in normal and left heart hypoplasia embryonic chick ventricles. J
Mol Cell Cardiol 2000;32:A28.
82. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Force-frequency relations in developing chick myocardium. Exp Clin Cardiol 2000;5:47.
83. Tobita K and Keller BB: RV and LV epicardial strain patterns in normal embryonic chick heart and following left
heart hypoplasia. Exp Clin Cardiol 2000;5:50.
84. Tobita K and Keller BB: Mechanical regulation of left ventricular development in embryonic chick ventricle. Weinstein Cardiovascular Development Conference, St. Louis, June 2000.
85. Schroder EA and Keller BB: Effects of temperature on force-velocity relations in the developing chick myocardium.
Weinstein Cardiovascular Development Conference, St. Louis, June 2000.
86. Tobita K, Schroder EA, Tinney JP, and Keller BB: Passive biaxial ventricular pressure-strain relations during normal development and altered loading conditions in the chick embryo. Weinstein CV Development Conference, Dallas, May 2001.
87. Tobita K, Tinney JP, and Keller BB: Assessment of embryonic mouse heart function using Doppler echocardiography
and maternal isoflurane anesthesia. Weinstein Cardiovascular Development Conference, Dallas, May 2001.
88. Sedmera D, Hu N, Keller BB, Denslow S, and Thompson RP: Label-dilution approach to study changes in cell proliferation: a teratologist’s dream come true. Weinstein Cardiovascular Development Conference, Dallas, May 2001.
89. Keller BB, Tinney JP, and Tobita K: Cardiovascular phenotype assessment using transabdominal echocardiography
and maternal anesthesia. Poster, World Congress of Pediatric Cardiology and Cardiac Surgery, Toronto, May 2001.
90. Tobita K, Tinney JP and Keller BB: Passive biaxial ventricular wall stress-strain relations during normal and altered load in the chick embryos. Experimental Biology, Orlando, FL 2001.
91. Garrison JB, Tobita K, Keller BB: Effects of cyclic stretch stimulation on embryonic ventricular cell orientation and
shape. University of Kentucky Gill Cardiovascular Research Symposium, Lexington, KY, October 2001.
92. Schroder EA, Tobita K, Tinney JP, Foldes J, and Keller BB: Microtubule involvement in the adaptation to altered mechanical load. Biophysics Society Meeting, San Francisco, CA, February 2002.
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93. Tobita K, Garrison JB, and Keller BB: Three-dimensional fiber architecture of the embryonic left ventricle during normal development and reduced mechanical load. Weinstein Cardiovascular Development Conference, Salt Lake City, May 2002.
94. Schroeder EA, Tobita K, Tinney JP, Foldes J, and Keller BB: Microtubule involvement in the adaptation to altered mechanical load in developing chick myocardium. Weinstein Cardiovascular Development Conference, May 2002.
95. Poma CP, Shulimovich M, Tobita K, Keller BB, Pennisi D, and Mikawa T. Hemodynamics induce and pattern purkinje fiber differentiation. Weinstein Cardiovascular Development Conference, Salt Lake City, May 2002.
96. Tobita K, Garrison JB, and Keller BB: Developmental change of three-dimensional fiber architecture of the embryonic left ventricle during reduced mechanical load. Comparative Physiology Roundtable Meeting, Glenn Rose, TX 2002.
97. Tobita K, Garrison JB, and Keller BB: Differential effects of cyclic stretch on embryonic ventricular myocyte and non-myocyte orientation. Etiology and Morphogenesis of Congenital Cardiovascular Disease in the Post-Genomic Era: New Takao Symposium, Tokyo, Japan, December 2002
96. Tobita K, Tinney JP, and Keller BB: Residual strain in embryonic left ventricle following normal and altered
mechanical load in the chick embryo. Weinstein Cardiovascular Development Conference, Boston, MA, May 2003.
97. Nordman CR, Tobita K, Lucitti JL, and Keller BB: Impact of chronic hypoxia exposure on vascular impedance in
early developing chick embryo. 2003 Children's Hospital of Pittsburgh Summer Student Research Poster Session, August 2003
98. Nonemaker JL, Tobita K, Liu LL, and Keller BB: Response of microtubule network to mechanical stretch in embryonic
ventricular cells. 2003 Children's Hospital of Pittsburgh Summer Student Research Poster Session, August 2003 99. Tobita K, Liu JL, and Keller BB: Engineered three-dimensional cardiac tissue from early embryonic chick
myocardium. Tissue Engineering Society International, 6th Annual International Conference and Exposition, Orlando, FL, October 2003
100. Sharma S, Tobita K, Tinney JP, and Keller BB: Regulation of cardiovascular structure and function by oxygen tension in chick embryos. 2004 American Heart Association Research Fellow Symposium, Pittsburgh, February 2004
101. Lucitti JL, Tobita K, and Keller BB: Impact of altered mechanical load on dorsal aortic impedance in the developing chick embryo. 2004 McGowan Institute for Regenerative Medicine Planning Retreat. Nemacolin, February 2004
102. Tobita K, Liu LL, Tinney JP, and Keller BB: Engineered embryonic cardiac tissue: Initial Experience. 2004 McGowan
Institute for Regenerative Medicine Planning Retreat. Nemacolin, February 2004
103. Saaloukeh ME, Tobita K, Momoi N, Tinney JP, Keller BB: Adverse effects of caffeine on embryonic cardiac function during early cardiac morphogenesis. Midwest Society for Pediatric Research Meeting, St. Louis, MO, 2004.
104. Tobita K, Liu LJ, Janczewski AM, Shroff SG, Keller BB: Three-dimensional engineered early embryonic cardiac tissue
(EEECT). Joint meeting of the Tissue Engineering Society International and the Europe Tissue Engineering Society, Lausanne, Switzerland, 2004
105. Lucitti JL, Tobita K, and Keller BB: Altered mechanical load impacts arterial hemodynamics and structure during
cardiogenesis. Experimental Biology 2004. FASEB JOURNAL v.18(#4), pp. A1247-A1247. 2004. 106. Lucitti JL, Tobita K, Keller BB: Impact of altered mechanical load on dorsal aortic impedance during cardiovascular
morphogenesis. Weinstein Cardiovascular Development Research Meeting, Leiden, Netherlands 2004 107. Momoi N, Tobita K, Tinney JP, Saaloukeh ME, Liu JL, Elshershari H, Keller BB, Adverse effects of caffeine on
embryonic cardiac function during early cardiac morphogenesis. PAS meeting, Washington DC, 2005
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108. Manole MD, Hickey RW, Momoi N, Tobita K, Tinney JP, Gabriel S, Clark R, Keller BB. Preterminal gasping is
associated with increased cardiac output and increased time till cardiac arrest in immature rats exposed to anoxia. PAS meeting, Washington DC, 2005
109. Lucitti JL, Tobita K, and Keller BB. Impact of altered mechanical load on dorsal aortic impedance during
cardiovascular morphogenesis. 2004 Weinstein Cardiovascular Development Meeting. Leiden, the Netherlands. 110. Tobita K, Liu LJ, Janczewski AM, Shroff SG, Keller BB: Three-dimensional engineered early embryonic cardiac
tissue (EEECT). Tissue Engineering Society International 7th Annual International Conference and Exposition and joint meeting of the Tissue Engineering Society International and the Europe Tissue Engineering Society, Lausanne, October, 2004.
111. Fujimoto, KL, Tobita K, Momoi N, Keller BB, Guan J, and Wagner WR : Cardiac remodeling by elastic biodegradable
cardiac patch covering the infarction area. 2005 McGowan Institute for Regenerative Medicine Planning Retreat. Nemacolin, March 2005
112. Lucitti JL and Keller BB: Increased arterial load impacts pulse wave velocity in chick embryos. Experimental Biology
2005, San Diego, CA 113. Tobita K, Liu JL, Janczewski AM, Tinney JP, Nonemaker JM, Augustine S, Stolz DB, Shroff SG, Keller BB.
Engineered early embryonic cardiac tissue (EEECT) retains proliferative and contractile properties of developing embryonic myocardium. Weinstein Cardiovascular Development Research Meeting, St. Petersburg, FL 2006
114. Fujimoto KL, Tobita K, Momoi N, Keller BB, Guan J, Wagner WW : Elastic, biodegradable cardiac patch induces
contractile smooth muscle bundles in sub-acute myocardial infarction, improving cardiac remodeling and function. American Heart Association 2005 Scientific Sessions, Dallas, TX
115. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB, Peault B, Huard J. Identification of a progenitor cell population from human skeletal muscle that is superior to committed skeletal myoblasts for cardiac cell therapy. AHA-BCS meeting, Denver, CO, 2006.
116. Keller BB, Liu LJ, Tinney JP, Tobita K. Lessons from embryos: insights into cardiovascular morphogenesis and adaptation. World Congress of Biomechanics, Munch, Germany, 2006.
117. Tobita K, Choi B, Liu LJ, Chey E, Tinney JP, Salama G, Keller BB. Impact of cyclic electric stimulation on
engineered early embryonic cardiac tissue. World Congress of Tissue Engineering, Pittsburgh, PA 2006.
118. Ahmad F, Lage ML, Janczewski AM, Tobita K, Smith S, Saba S, Conner DA, Tinney JP, Ragwe J, Moskiwitz IP, Perez-Atayde AP, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG. Cardiomyopathies secondary to cardiac troponin T mutations result from abnormal protein function rather than haploinsufficiency. AHA annual meeting, Chicago, 2006.
119. Funari BJ, Witt MR, Clause KM, Keller BB, Tobita K, Ralphe JC. The impact of energy substrate on contractile performance in a neonatal rat engineered cardiac tissue model. 2007 Pediatric Academic Societies’ meeting, Toronto, 2007.
120. Kreutzer J, Emery SP, Sherman FR, Fujimoto KL, Jaramaz B, Nikou C, Tobita K, and Keller BB. Novel computer assisted electromagnetic navigation for prenatal catheter intervention. Pediatric Interventional Cardiac Catheterization Conference, Las Vegas, NV, 2007
121. Clause K, Tinney JP, Liu JL, Keller BB, Tobita K. p38 MAP-kinase regulates engineered early embryonic cardiac tissue proliferation and contractile properties. Weinstein Cardiovascular Development Research Meeting, Indianapolis, IN 2007.
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122. Clause K, Tinney JP, Liu JL, Burhan B, Fujimoto KL, Wagner W, Ralphe JC, Keller BB, Huard J, Tobita K. Functioning engineered cardiac tissue from skeletal muscle derived stem cells. Weinstein Cardiovascular Development Research Meeting, Indianapolis, IN 2007.
123. Momoi N, Tinney K, Liu JL, Elshershari H, Hoffman P, Ralphe JC, Keller BB, Tobita K. Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth. Weinstein Cardiovascular Development Research Meeting, Indianapolis, IN 2007.
124. Paladino LK, Keller SJ, Keller JM, Farrington J, Andre D, Wolf D, Gu H, Wang SB, Keller BB. Heart Rate, Oxygen Saturation, and Blood Pressure Response to Exercise in Children With and Without Congenital Heart Disease at High Altitude in the Tibet Autonomous Region, PRC. 2007 Children's Hospital of Pittsburgh Summer Student Research Poster Session.
125. Park G, Clause KC, Tinney JP, Liu JL, Gharaibeh B, Fujimoto KL, Wagner W, Huard J, Keller BB, Tobita K. Cardiomyocyte induction from skeletal muscle derived stem cells (MDSCs) using MDSC sphere formation and 3-dimensional MDSC-engineered cardiac tissue construction. 2007 Children's Hospital of Pittsburgh Summer Student Research Poster Session.
126. Freytes DO, Tobita K, Tinney JP, Keller BB, Wainwright JW, Martin J, Velankar SS, Badylak SF. Extracellular Matrix Derived Gel for Cardiac Tissue Engineering Applications. International Biomaterial Meeting, Orlando, FL, 2007
127. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB. Phillippi JB, Peault B, Huard J. Identification of a lineage of myogenic-endothelial cells in adult human skeletal muscle that are superior to myoblast for myocardial infarct repair. 5th Annual Meeting International Society for Stem Cell Research Cairns, Australia, 2007.
128. Fujimoto KL, Tobita K, Guan J, Keller BB, Wagner WR. Elastic, biodegradable cardiac patch implantation induces embryonic-like cellularization in the post-infarct ventricular wall. AHA annual meeting, Orlando, FL, 2007.
129. Emery SP, Kreutzer J, Sherman F, McCaffery F, Keller BB. Learning curve for a fetal cardiac intervention team.
Society for Maternal-Fetal Medicine 28th Annual Scientific Meeting, Dallas, TX, 2008. 130. Wang Y, Dur O, Patrick MJ, Tinney JP, Tobita K, Pekkan K, Keller BB. Hemodynamic investigation of normal developing aortic arch in the chick embryo. ASME 2008 Summer Bioengineering Conference (SBC2008) Marco Island, Florida, USA 131. Drummond A, Keller BB, Borovetz HS, Antaki JF. Anatomic database for insertion of VADS in infants and young children.ASME 2008 Summer Bioengineering Conference (SBC2008) Marco Island, Florida, USA 132. Drowley L, Okada M, Tobita K, Keller BB, Huard J. Treatment of muscle stem cells with N-acetylcysteine increases survival and resistance to stress. Tissue Engineering and Regenerative Medicine International Society 2008. 133. Wang Y, Patrick MJ, Dur O, Keller BB, Pekkan K. Hemodynamic investigation of normal aortic arch development
in the chick embryo. Carnegie Mellon University 2008 Bioimaging Conference, Pittsburgh, PA 134. Dur O, Pekkan K, Dasi LP, Keller BB, Fogel MA, Yoganathan A. In vitro hemodynamics of embryonic aortic arch
with tetralogy of Fallot at late gestation. 2008 CalTech Biofluids Conference, Pasadena, CA 135. Ralphe JC, Witt M, Kirk J, Clause KM, Keller BB, Tobita K. Engineered Neonatal Rat Cardiac Tissue Models
Immature in vivo Myocardium. American Heart Association 2008 Scientific Sessions, New Orleans, LA. Circulation 2008;118:S 281
136. Drowley L, Cassino T, Okada M, Tobita K, Keller BB, LeDuc P, Huard J. Stem Cell Transplantation for Cardiac
Repair is improved by Mechanical Preconditioning. Experimental Biology 2009.
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137. Clause K, Li, JL, Powell MC, Keller BB, Gharaibeh B, Huard J, Tobita K. Skeletal muscle specific fast myosin heavy chain is present in the developing ventricular myocardium. NHLBI Symposium on Cardiovascular Regenerative Medicine, Bethesda, October, 2009
138. Dur O, Wang Y, Patrick MJ, Tinney J, Keller BB, Pekkan K. Correlation of wall shear stress and pharyngeal arch
lumen diameter during early embryonic development in the chick, Biomedical Engineering. Society Annual Fall Meeting, Pittsburgh, PA, October 2009.
139. Clause KC, Tinney JP, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller BB,
Tobita K. Impact of cyclic mechanical stretch on muscle stem cell derived cardiomyocyte 3D engineered tissue. Biomedical Engineering. Society Annual Fall Meeting, Pittsburgh, PA, October 2009.
140. Pekkan K, Jamaly M, Kara B, Sotiropoulos F, Keller BB. Early embryonic intra-cardiac flow fields at three idealized
ventricular morphologies, APS Division of Fluid Dynamics 62nd Annual Meeting, November 2009 141. Kowalski WJ, Dur O, Keller BB, Pekkan K. Investigating the growth and remodeling of the embryonic aortic arch
manifold through a CFD coupled 2D optimization framework. Sixth MIT Conference on Computational Fluid and Solid Mechanics, Cambridge, MA, June 2010
142. Jackson D, Blake J, Miller D, Naber J, Walsh K, Woods C, Keller BB, Reimer P, Beeler S. A Wireless Body
Temperature Monitor for the Prevention of Febrile Seizures. 6th Annual Kentucky Innovation and Entrepreneurship Conference, Lexington, K, 2010
143. Keller BB, Downs-Canner S, Hornung CA, Gu H. Detection of congenital heart disease using 5 minute exercise
screening for high altitude, rural Tibetan children. 20th World Congress of the World Society of Cardio Thoracic Surgeons, Chenai, India, October 2010.
144. Geppert M, Wang SB, Laba ZM, Ren QCW, Meiji M, Kai W, Ng L, Geppert M, Neches WH, Yong BH, Nakanishi T,
Gu H, Keller, BB. Mid-term results of the screening and treatment of congenital heart disease at high altitude: The Touching Hearts in Tibet Program. 20th World Congress of the World Society of Cardio Thoracic Surgeons, Chenai, India, October 2010.
145. Kowalski WJ, Teslovich NC, Dur O, Keller BB, Pekkan K. Characterization of the outflow tract-aortic arch angle
during embryonic development in the chick. BMES 2010 Annual Meeting; 2010 October 6-9; Austin, TX 2010. 146. Kowalski WJ, Teslovich NC, Dur O, Keller BB, Pekkan K. Hemodynamics of aortic arch morphogenesis. USNCB
3rd Symposium on Frontiers in Biomechanics: Mechanics of Development; 2011 June 21; Farmington, PA 2011. 147. Wang Y, Ferreira A, Keller BB, Simon M, Antaki JF. Effect of continuous-flow left ventricular assist device on
cardiac function: simulation study with a refined computer model. ASME 2011 Summer Bioengineering Conference SBC2011, June 22-25, Farmington, PA
148. Tchao JS, Clause KC, Keller BB, Huard J, Shroff S, Franks J, Davidson L, Tobita K. Local mechanical strain
influences cardiomyocyte differentiation in skeletal muscle stem cell within 3-dimensional collagen gel bioreactor. NHLBI Symposium on Cardiovascular Regenerative Medicine, DC, 2011.
149. Black AK, Raymon S, Hornung C, Mascio C, Keller BB. Interim results of the pediatric cardiovascular home
telehealth project. Research Louisville!2011. Louisville, KY October, 2011 150. Sadanala U, Ymalay R, Raymon S, Tinney JP, Kriss V, Keller BB. Initial observations using high resolution
VEVO2100 ultrasound imaging in neonates. Research Louisville!2011. Louisville, KY October, 2011 151. Kmetz DJ, Tinney JP, Dale J, Krishnan L, Hoying JB, Keller BB. Characterization of vascular maturation within
engineered cardiovascular tissues. Research Louisville!2011. Louisville, KY October, 2011
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152. Teslovich NC, Kowalski WJ, Tinney JP, Keller BB, Pekkan K. Altered intracardiac flow patterns in the left atrial ligated chick embryo. BMES 2011 Annual Meeting; 2011 October 13-15; Hartford, CT 2011.
153. Ymalay R, Sadanala U, Tinney JP, Kriss V, Keller BB. Initial observations and limitations of VEVO2100 high
resolution ultrasound imaging in neonates. Souther Society for Pediatric Research, New Orleans, February 2012. 154. Ymalay R, Sadanala U, Tinney JP, Kriss V, Keller BB. Initial observations and limitations of VEVO2100 high
resolution ultrasound imaging in neonates. American Pediatric Society, Boston, MA, May 2012 155. Kowalski WJ, Dur O, Wang Y, Keller BB, Pekkan K. Hemodynamics of the transitional aortic arch patterning at a
key embryonic stage. International Society for Applied Cardiovascular Biology's (ISACB) 13th Biennial Meeting, London, UK. September 2012
156. Trada HV, Tinney JP, Jackson DJ, Walsh KM, Naber JF, Keller BB. Development of porous multiple electrode
arrays (P-MEA) for electrical stimulation and pacing of engineered cardiac tissue (ECT). Fifth Annual Nanotechnology and Nanomedicine Symposium, Sullivan University, Louisville, KY, September 2012
157. Keller BB, Ye F, Yuan FP, Li X, Tinney JP. Gene Expression Profiles in Engineered Cardiac Tissues Respond to
Mechanical Loading and Inhibition of Tyrosine Kinases. Platform Presentation. 2013 World Congress of Pediatric Cardiology & Cardiac Surgery, Cape Town, South Africa, February 2013.
158. Keller BB, Black AK, Sadanala UK, Mascio CE, Hornung CA. Challenges in Implementing a Pediatric
Cardiovascular Home Telehealth Project. Poster Presentation. 2013 World Congress of Pediatric Cardiology & Cardiac Surgery, Cape Town, South Africa, February 2013.
159. Nguyen MD, Tinney JP, Yuan FP, Roussel T, Giridharan G, Keller BB, Sethu P. An in-vitro model system for
generation of mechanically conditioned cardiac tissue constructs. 7th International Conference on Microtechnologies in Medicine and Biology, MMB 2013 Conference, Marina del Ray, California, April 2013.
160. Allen N, Tinney JP, Yan FP, Keller BB, Soucy P. Extracellular matrix production from chicken cardiac fibroblasts
under different conditions. 2013 University of Louisville Summer Student Research Opportunity Program. 161. Kowalski WJ, Dur O, Wang Y, Tinney JP, Keller BB, Pekkan K. Hemodynamics of the transitional aortic arch
patterning at a key embryonic stage. Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology. 2013;22(3):e49.
162. Ye F, Yuan FP, Li X, Cooper N, Tinney JP, Keller BB. Gene Expression Profiles in Engineered Cardiac Tissues
Respond to Mechanical Loading and Inhibition of Tyrosine Kinases. 2013 American Heart Association Scientific Sessions, Dallas, TX, November 2013.
163. Goktas S, Kowalski WJ, Keller BB, Pekkan K. Hemodynamic regulation of vascular growth and remodeling in the
chick embryo: time-lapse imaging and RT-PCR analysis. 7th World Congress of Biomechanics; 2014 July 6-11; Boston, MA 2014.
164. Kowalski WJ, Teslovich N, Chen V, Keller BB, Pekkan K. Simultaneous real-time quantification of blood flow and
vascular growth in the chick embryo using optical coherence tomography. SPIE 2014, San Francisco, CA, Feb 2014 165. Masumoto H, Nakane T, Tinney JP, Yuan FP, Kowalski WJ, Ye F, Sakata R, Yamashita JK, and Keller BB.
Development of 3D Engineered Cardiac Tissue with Human iPS Cell-derived Cardiomyocytes and Endothelial Cells. ISSCR2015, Stockholm, Sweden, June 2015
166. Uslu FE, Goktas S, Kowalski WJ, Keller BB, Pekkan K. Characterization of pulsatile wall shear stress at the vitelline
artery during early embryonic development. 11th International Symposium on Particle Image Velocimetry; 2015 September 14-16; Santa Barbara, CA 2015.
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167. Dwenger M, Barve A, Nakane, T, Tinney JP, Beverly B, Keller BB. Design and Fabrication of an Optically Activated Engineered Cardiac Tissue. 2015 Research! Louisville, University of Louisville School of Medicine, Louisville, KY, October 2015
168. Masumoto H, Nakane T, Tinney JP, Yuan FP, Ye F, Kowalski WJ, Minakata K, Sakata R, Yamashita JK, and Keller
BB. The Potential of Three-Dimensional Engineered Cardiac Tissues Composed of Multiple Human iPS Cell-Derived Cardiovascular Lineages for Cardiac Regeneration. American Heart Association 2015 Scientific Sessions, Orlando, FL. November 2015
169. Morgan LM, Peek ML, Raj AB, Sullivan JE, Keller BB. Validation of point of care testing versus clinical
venipuncture: a prospective cohort study. Cardiology 2016: 19th Annual Update on Pediatric and Congenital Cardiovascular Disease, Orlando, FL, Feb 2016 (poster presentation)
170. Nakane T, Masumoto H, Tinney JP, Yuan FP, Kowalski WJ, Ye F, Sakata R, Yamashita JK, and Keller BB.
Development of a large format engineered cardiac tissue from human iPS cell-derived cardiac cells. ISSCR2016, San Francisco, CA, June 2016
171. Dwenger M, Kowalski WJ, Ye F, Setozaki S, Nakane T, Yuan F, Tinney JP, Campbell P, Guido W, Keller BB.
Chronic Optogenetic Pacing of human iPSC-derived Engineered Cardiac Tissues. 2017 Research! Louisville, University of Louisville School of Medicine, Louisville, KY, October 2016
172. Nakane T, Masumoto H, Tinney JP, Yuan FP, Kowalski WJ, Ye F, Minakata K, Ikeda T, Sakata R, Yamashita JK,
and Keller BB. Impact of geometry and cell density on structural and functional maturation in large-format mesh engineered cardiac tissues generated from human iPS cells, American Heart Association 2016 Scientific Sessions, New Orleans, FL. November 2016
173. Ye F, Setozaki S, Kowalski WJ, Dwenger M, Yuan FP, Tinney JP, Nakane T, Masumoto H, and Keller BB. Progress
in the generation of multiple lineage human-iPSC derived 3D engineered cardiac tissues for cardiac repair. Accepted for platform presentation, 7th World Congress of Pediatric Cardiology and Cardiac Surgery, Barcelona, Spain July 16-21, 2017.
174. Ye F, Setozaki S, Kowalski WJ, Dwenger M, Yuan FP, Tinney JP, Nakane T, Masumoto H, and Keller BB.
Application of optogenetics and human compatible reagents in the generation of multiple lineage human-iPSC derived 3D engineered cardiac tissues for cardiac repair. Invited Lecture, the 8th Takao International Symposium on Molecular Mechanisms of Cardiopulmonary Disease. Matsue, Japan October 6-8, 2017.
175. Dwenger M, Kowalski WJ, Ye F, Yuan F, Tinney JP, Setozaki S, Nakane T, Campbell P, Guido W, Keller BB.
Chronic Optogenetic Pacing of human iPSC-derived Engineered Cardiac Tissues. 2017 Research! Louisville, University of Louisville School of Medicine, Louisville, KY, October 2017
176. Ye F, Setozaki S, Kowalski WJ, Dwenger M, Yuan FP, Tinney JP, Nakane T, Masumoto H, and Keller BB.
Generation of multiple lineage human-iPSC derived 3D engineered cardiac tissues for cardiac repair. Weinstein Cardiovascular Development and Regeneration Conference, Nara, Japan, May 2018
177. Yu H, Ye F, Yuan F, Kang Y, Cai L, Ji H, Keller BB. Neonatal murine engineered cardiac tissue toxicology Model:
Impact of metallothionein overexpression, cadmium exposure, and zinc countermeasures. 2018 Research! Louisville, University of Louisville School of Medicine, Louisville, KY, October 2018
178. Yu H, Ye F, Yuan F, Kang Y, Cai L, Ji H, Keller BB. Neonatal murine engineered cardiac tissue toxicology Model:
Impact of metallothionein overexpression, cadmium exposure, and zinc countermeasures. Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019
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L. Disclosures and Patent Filings 1. Biodegradable Elastomeric Patch for Treating Cardiac or Cardiovascular Condition. Inventors: William R. Wagner, JIanjun
Guan, Kazuro L. Fujimoto, Kimimasa Tobita, Bradley B. Keller. University of Pittsburgh. Publication number: 20150132251, Filed January 15, 2015
2. Functioning Cardiomyocyte Induction from Skeletal Muscle Derived Stem Cell using Rotation and 3-Dimensional Collagen
Culture. Inventors: Kimimasa Tobita; Johnny Huard; Kazuro L. Fujimoto; Bradley B. Keller. IDF 1518. Disclosure Filed June 27, 2007. University of Pittsburgh
3. Porous Microelectrode Arrays Combined with Three-Dimensional Engineered Cardiac Tissue Constructs for Cardiac Repair
and Regeneration. Inventors: Bradley B. Keller, Joseph P. Tinney, Hiren Trada, Kevin M. Walsh, Douglas Jackson, John F. Naber. US-Provisional Patent Filed January 7, 2014 EFS ID 17839442 Appl# 61924408 Conf#5930
4. Therapeutic Agent for heart Diseases Comprising Cardiomyocytes, Endothelial Cells and Parietal Cells Produced from
Pluripotent Stem Cells. Inventors: Bradley B. Keller, Hidetoshi Masumoto, Takeichiro Nakane, Jun Yamashita. International Provisional Patent Filed October 30, 2015. #62/248,771. (by CiRA)
5. Engineered Cardiac Tissue and Related Methods. Inventors: Bradley B. Keller, Takeichiro Nakane, Jun Yamashita,
Hidetoshi Masumoto. International Patent Filed January 11, 2017, PCT/US17/13001 (by UofL Research Foundation)
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M. Research Funding GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT Ventricular Mechanics in the Developing Chick Heart. 07/01/88 - 06/31/90 $53,400 PI, 85% FTE, NIH-NRSA #F32-HL07824. Ventricular Mechanics in the Chick Embryo 07/01/90 - 06/31/95 $371,730 PI, 85% FTE, NIH-PSA-K11-HL02498. Calcium Kinetics in the Embryonic Chick Myocyte 07/01/91 - 06/31/93 $6,000 PI, Univ. of Roch. Strong Childrens Research Center Ventricular Mechanics in the Developing Embryonic Heart 07/01/91 - 06/31/96 $854,095 L. Taber, PI, B. Keller, co-PI, 10% FTE, NIH-RO1-HL46367. Ventricular/Vascular Coupling in the Chick Embryo 07/01/93 - 06/31/96 $118,000 PI, 20% FTE, American Heart Association, Grant-in-Aid, 93-1013 NIH SCOR: Bench to Bedside, Biomechanics of the 05/31//93 - 12/31/98 $4,750,000 Developing Cardiovascular System. 75% FTE, NIH-P50-HL51498 E. Clark, PI 1/1/93 - 5/31/95, B. Keller, PI 5/31/95 – 12/31/98 Murine Embryonic Cardiovascular Functional Maturation 07/01/95 - 06/31/96 $15,000 PI, 15% FTE, Strong Childrens Research Center Mechanical Properties of Chick Embryonic Myocardium 07/01/95 - 06/31/98 $60,000 Fogarty International Award. B. Keller, P.I., 5% FTE; P. Tsyvian, Russian collaborator, NIH-RO3-TW00527 Active Myocardial Mechanics During Development and Disease 07/01/97 - 06/31/99 $45,000 PI, 5% FTE, Civilian Research and Development Foundation, #5270 V. Markhasin, Russian co-PI In Utero Murine Embryo CV Phenotype Screening 09/01/00 - 07/31/04 $1,480,897 B. Keller, PI, 30% FTE, NHLBI RFA RO1 HL65219-01 Adaptation of the embryonic myocardium to altered load. 02/01/01 - 01/31/05 $1,421,951 B. Keller, PI, 30% FTE, NHLBI RO1 HL64626-01-A1 Modulation of T-type Calcium Channels. J. Satin, P.I. 07/01/00 - 06/31/04 consultant NHLBI RO1 HL63416-01 B. Keller, consultants Biomechanical Adaptation of Embryonic Myocardium to 09/01/00 - 08/31/03 $18,000 Chronic Hemodynamic Alteration. NATO Collaborative Linkage Grant. B. Keller, PI, P. Tsyvian, Partner Country PI Prenatal Fetal Cardiovascular Interventions 10/01/03 – 09/31/04 $58,500 PNC Charitable Trust. B. Keller, PI Novel Technology Development for Fetal Cardiac Intervention 12/01/03 - 11/31/04 $60,000 Pittsburgh Life Science Greenhouse award to Verimetra, Inc, B. Keller, PI CHP subcontract NIH SBIR Circulatory Support Device for Toddlers/Small Children 02/04 - 01/05 consultant J. Antaki (Launch Point Technologies), PI, B. Keller, CHP subcontract PI, 3% FTE
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GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT Prenatal Fetal Cardiovascular Interventions 10/01/03 – 09/31/04 consultant NHLBI Phase I SBIR, CASurgica, Inc, B. Keller, CHP consultant R43HL076961-01
NHLBI RFA SCCOR in Pediatric Cardiovascular Disease 01/01/04 - 12/31/09 $13,450,000 Optimizing Outcomes After Pediatric Heart Transplantation S. Webber, PI, B. Keller, co-PI, 10% FTE P50-HL074732-02 NIH BAA Pediatric Ventricular Assist Device for the 3 to 15 Kilogram 03/15/04 – 02/14/09 $4,490,691 Patient. H. Borovetz, PI, B. Keller, CHP subcontract PI, 8% FTE NIH- HSN268200448192C Engineered Early Embryonic Cardiac Tissue (EEECT) 05/15/05 - 03/31/07 $387,665 B. Keller, PI, 20% FTE, NHLBI R21 HL079998-01 Prenatal Fetal Cardiovascular Interventions 04/01/06 – 03/31/08 $272,875 NHLBI Phase II SBIR, CASurgica, Inc, B. Keller, PI CHP subcontract, 15% FTE, NIH/NHLBI 2R44 HL076961-02A1 Tissue Engineered Grafts for Congenital Heart Surgery 7/1/06 – 5/31/07 $60,000 PA Department of Health, MIRM, B. Keller, PI MEMS Blood Pressure Sensor for Pediatric VAD 07/01/07 - 05/31/08 B. Norling, PI (Launchpoint Technologies), B. Keller, consultant NIH SBIR R43-HL087446-01-A1 Bioengineering Analysis of Embryonic Hypoplastic Aortic Arch 07/01/07 – 06/31/09 $132,000 During the Period of Arterial Morphogenesis. K. Pekkan (CMU), PI, B. Keller, Co-I, Mid-Atlantic AHA Affiliate Beginning Grant-in-Aid Mitochondrial Maturation and Function in the Engineered Embryonic 07/01/07 – 06/31/09 Heart Model J. Carter Ralphe, PI, B. Keller, consultant, Mid-Atlantic AHA Affiliate Grant-in-Aid Engineered Cardiac Tissues for Pediatric and Adult Patients 7/1/07 – 5/31/08 $60,000 PA Department of Health, MIRM, B. Keller, PI VisualSonics Vevo770 Ultrasound Biomicroscopy and Microinjection Core. 09/29/07 $377,815 B. Keller, PI NCRR/NIH 1S10RR024741-01 Magnetic Navigated Image Overlay for Vascular Access- MNIO-VA 12/1/07 – 07/31/09 $147,279 B. Keller, PI, NIH 1R41HL091553-01 Engineered Early Embryonic Cardiac Tissue 07/01/08 – 06/31/13 $1,817,125 B. Keller, PI, NHLBI RO1 HL085777-01-A2 PELEX-C: A high-resolution wireless ECG system for infants/children 09/01/08 – 08/31/09 $155,815 B. Keller, PI (PinMed, Inc). NIH R41HL093953-01 Ultrasound-Enhanced Gene Delivery Validation in Genetic Mouse Models 07/01/08-06/31/09 $50,000 E. Goetzman and B. Keller co-PIs, VisualSonics, Inc. product enhancement grant Three-Dimensional Cardiac Gel Bioreactor for Functioning 07/01/09 – 11/30/11 $250,000 Cardiomyocyte Induction from Human Skeletal Muscle Derived Stem Cells K. Tobita PI, B. Keller, co-I, NIH R21 HL094402-01
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GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT Kosair Charities Pediatric Heart Research Program 05/01/09 – 07/01/17 $1,400,000 B. Keller, PI A Wireless Temperature Monitor for Children 01/01/10 – 12/31/10 $75,000 J. Naber, PI, B. Keller, co-PI (5% FTE) and Simon Sounds, Inc. Kentucky Commercialization Funds University of Louisville Pediatric Home TeleHealth Demonstration 07/01/10 – 06/31/12 $200,000 Project: Home TeleCare for High-Risk Pediatric Cardiac Patients B. Keller, PI (10% FTE). University of Louisville Clinical Translational Science Pilot Project Program Regenerative Potential of Umbilical Cord Derived Mesenchymal Stem 08/01/11 – 07/31/12 $50,000 Cells in Pediatric Cardiovascular Repair. L. Krishnan, PI, B. Keller, co-PI (NSS). Kosair Charities Pediatric Heart Research Program Pilot Grant Blood filtration system for the treatment of severe malaria patients 07/01/12 – 06/30/13 NSS inflammatory events. A. Gandini (Tropical Health Systems, LLC) PI, B. Keller, consultant, NIH R43 HL110508-01A1 Miniature external components for CircuLite’s pediatric circulatory 04/01/13 – 12/31/15 $43,299 support systems. NIH 1R44HL118933-01 (FastTrack) A. Drummond, PI (CircuLite), B. Keller, co-I (5% FTE) *Declined after CircuLite was purchased by HeartWare. Magnetic cellular assembly and microfluidic conditioning for 08/13/13 -07/15/15 $499,774 generation of functional cardiac tissue NIH 1R15HL115556-01A, P. Sethu, PI, B. Keller, co-I, (5%) SBIR Topic 97 – Minimally invasive test for chemotherapy-induced 08/10/16 – 08/09/17 NSS Cardiotoxicity – Phase I A. Gandini (Accel Diagnostics, LLC) PI, B. Keller, consultant, 268201600027C-0-0-1 Plasticity in the CNS and ANS after spinal cord injury. 07/01/15 – 12/15/17 Helmsley Charitable Trust (D. Magnuson, PI, B. Keller, co-I, 7.5%) A rapid instrument-free diagnostic assay for the early detection and 06/15/16 – 05/31/17 quantification of sepsis biomarkers in blood. NIH R43 AI25013-01 (Phase I) A. Gandini (Tropical Health Systems, LLC) PI, B. Keller, consultant, CURRENT FUNDING The Scientific Foundation: Building Evidence for Activity-based 11/01/15 – 11/01/18 Therapies for Children with Paralysis Helmsley Charitable Trust Award. (A. Behrman, PI, B. Keller, co-I, 2.5%) A disposable assay for the monitoring of heart failure in the home setting. 04/01/15 – 04/30/19 A. Gandini (Accel Diagnostics, LLC) PI, B. Keller, consultant, NIH R44 HL127880-02A1 (Phase II) UofL Environmental Health Science Training Program 04/01/16 – 03/31/21 NIH T32 ES011564-11A1 (G. Arteel, PI, B. Keller, mentor) Engineered Cardiac Tissues: A 3D in vitro model of diabetic myocardium 07/01/17 – 06/30/19 $50,000/yr US-China Pediatric Research Training Program at the University of Louisville (B. Keller and L. Cai, co-PI) Development of a Universal Maglev Driver for Five Pediatric Cardiac and 06/01/18 – 05/31/19 $417,132 Respiratory Applications. 1 R43 HL144214-01 (Phase I) K. Dasse (Inspired Therapeutics, LLC) PI, B. Keller, co-I
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CURRENT FUNDING (cont.) Arts Integration for the new Novak Center for Children’s Health 07/01/17 - 06/30/19 $100,000 Lift a Life Foundation Grant to the Fund for the Arts (FFTA), Christen Boone, President and CEO, FFTA B. Keller, Founder, Arts Integration Program for the Novak Center for Children’s Care RESEARCH PROPOSALS IN REVIEW RESEARCH PROPOSALS IN REVISION/PREPARATION Murine Engineered Cardiac Tissue Tox Model: Heavy Metal and Zinc (07/01/** – 06/30/**) $423,500 Treatment NIH 1 R21 ES030874-01 B. Keller, PI, L. Cai, co-PI (NIEHS, IRG: SIEE) Minimally invasive test for chemotherapy-induced Cardiotoxicity (08/10/** – 08/09/**) Cardiotoxicity. NIH R44 HL14436-01 A. Gandini (AccelDx, LLC) PI, B. Keller, consultant Score 42
MENTORED TRAINING GRANTS GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT Creation and Palliation of Functional and Structural 07/01/98 - 06/31/00 $70,000 Cardiovascular Defects in Chick Embryos. K. Tobita, fellow, B. Keller, sponsor AHA Fellowship Award (NY State Affiliate) Functional Maturation of Embryonic Myocardium. 07/01/99 - 06/31/02 $135,000 E. Schroder, PI, B. Keller, sponsor, 1F32-HL10200 NIH-individual NRSA post-doctoral fellowship award Functional Maturation of Embryonic Myocardium. 07/01/99 - 06/31/01 $50,000 E. Schroder, PI, B. Keller, sponsor AHA, Ohio Affiliate, Individual post-doctoral fellowship award (declined due to NIH award)
NHLBI RFA SCCOR in Pediatric Cardiovascular Disease 01/01/04 - 12/31/09 $500,000 Optimizing Outcomes After Pediatric Heart Transplantation, B. Keller, PI, Clinical Research Training Core NHLBI Cardiovascular Bioengineering Training Grant. 02/01/05 - 01/31/10 mentor S. Shroff, NIH T32HL76124-01 A1 PI, B. Keller, faculty mentor Functional Maturation of Embryonic Myocardium. 05/01/05 - 04/30/10 $633,150 NIH clinician/scientist training award K08 NIH HL074224-A1, J. Carter Ralphe, PI, B. Keller, sponsor
Simulation of Optimal Surgical Insertion of a Pediatric Ventricular 07/01/07 – 06/31/12 mentor Assist Device. NIH K31 HL090267-01. A. Drummond, PI, B. Keller, mentor Role of mechanical forces on cardiomyocyte induction from 07/01/08 – 06/31/10 mentor skeletal muscle derived stem cells in 3D culture. AHA pre-doctoral fellowship. K. Clause, PI Are Overweight Children with T1DM at Increased Risk of 07/01/08 – 06/31/11 mentor Cardiovascular Disease? American Diabetes Association Beginning Faculty Award I. Libman, PI Are Overweight Children with T1DM at Increased Risk of 07/01/08 – 06/31/13 mentor Cardiovascular Disease? NIH clinician/scientist training award K23 HL085287-01-A2 I. Libman, PI Oxidative stress in regional cerebral blood flow alterations 07/01/08 – 06/31/13 mentor after pediatric cardiac arrest. NIH clinician/scientist training award K08 HD058798-01 M. Manole PI
Curriculum Vitae -- Bradley B. Keller, MD
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CLINICAL RESEARCH GRANTS AND PROTOCOLS PATH-1, Pediatric use of Amlodipine in the Treatment of 07/01/99 - 06/31/00 $75,000 Hypertension. Pfizer Central Research, J.D. Moore, site-PI, University of Kentucky, B. Keller, co-P.I. Long-term Outcomes in Adult Congenital Heart Disease 07/01/00 - 07/31/02 B. Keller, PI, IRB#00-0482-P1R (University of Kentucky) Anatomic Modeling of Pediatric Patients for PVAD 07/01/06 – 06/30/08 B. Keller, PI, CORID #85 (University of Pittsburgh) Accuracy of Heart Rate and Oxygen Saturation Response to Exercise 07/01/07 – 05/01/09 At High Altitude (Tibet) to Detect Congenital Heart Disease, B. Keller, PI, SEAPC University of Pittsburgh IRB Protocol #PRO08030108 Approved 5/12/08 (200 subjects) PELEX-C: A high-resolution wireless ECG system for infants/children 07/01/07 – 05/01/09 B. Keller, PI, NIH/NHLBI, University of Pittsburgh IRB Protocol #PRO07100403 (5/15/08 -5/1/09) Capillary Leak Syndrome 04/01/11 – 03/31/12 B. Keller, PI, University of Louisville IRB Protocol # 10.0661, NHORA# 11.0046 (R. Salimi, MD, Pediatric Critical Care Fellow Scholarly Project) High Resolution Ultrasound Imaging in Neonates 04/14/11 – 03/16/14 B. Keller, PI, University of Louisville IRB Protocol # 11.0119, NHORA# 11.0062 (R. Ymalay, MD, Neonatal Medicine Fellow Scholarly Project) Pediatric Cardiovascular Home Telehealth Project 12/22/11 – 12/21/13 B. Keller, PI, University of Louisville IRB Protocol # 10.0619, NHORA# 10.0201 (A. Keskey-Black, MSII, UofL SOM Distinction in Research Scholarly Project) Validation of point-of-care INR testing with the goal of oral 06/27/13 – 06/19/16 Anticoagulation management B. Keller, PI, University of Louisville IRB Protocol #13.0211, NHORA# 13-N0116 (M. Peek, MD and L. Morgan, MD, Pediatric Resident Scholarly Projects) Anxiety, Depression, ADHD, Neurocognitive, and Quality of Life 10/29/15 – 10/28/19 Screening in Children Referred to and Following up in an Outpatient Cardiology Office. #15.0502 (A. Black, MD, R. Grisham, Pediatric Resident Scholarly Project) Panorama HF Trial. Multicenter, open-label, study to evaluate safety, 01/01/07 - present tolerability, pharmacokinetics and, pharmacodynamics of LCZ696 followed by a 52-week randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696 compared with enalapril in pediatric patients from 1 month to < 18 years of age with heart failure due to systemic left ventricle systolic dysfunction(J. Sparks, MD, PI, B. Keller, MD, co-I). Novartis, Protocol# CLCZ696B2319 Part 1 and Part 2, HSPPO# 16.1153, $557,406 PREVENT-HF Trial. Pharmacologic Reversal of Ventricular Remodeling 6/4/18 - present In Childhood Cancer Survivors at Risk for Heart Failure (PREVENT-HF):A Phase 2b Randomized Placebo-Controlled (Carvedilol) Trial.Children’s Oncology Group Study. (A. Cherva, MD, PI, B. Keller, MD, co-I). N. Clinical Service: Inpatient and outpatient pediatric cardiology since 7/1/91 without interruption 1. Ambulatory Pediatric Cardiology Office Hours in Louisville. 2. Outreach Pediatric Cardiology Office Hours at sites throughout the Commonwealth of Kentucky and southern Indiana. Paducah, Bowling Green, Elizabethtown, Glasgow, Campbellsville, Owensboro, Madisonville, Madison, Ashland, Murray 3. Inpatient Pediatric Cardiology Attending service at Norton Children’s Hospital and Norton Hospital.
Curriculum Vitae -- Bradley B. Keller, MD
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My Biography Link via PubMed: http://www.ncbi.nlm.nih.gov/sites/myncbi/1ts08qAhUhOk3/bibliography/48799272/public/?sort=date&direction=ascending O. Publications, Book Chapters, Monographs and Textbooks
INVITED REVIEWS 1. Keller BB and Clark EB: Cardiovascular structural and functional maturation. Current Opinion in Cardiology 1993;8:98-107. 2. Keller BB: Functional maturation and coupling of the embryonic cardiovascular system. In Developmental Mechanisms of
Heart Disease, (eds) EB Clark, RR Markwald, and A Takao, Futura Publishing, Mount Kisco, NY, 1995, 367-386.
3. Keller BB: Function, biomechanics and control of the embryonic cardiovascular system. In Etiology and Morphogenesis of Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology. (eds) EB Clark, M Nakazawa, and A Takao, Futura Publishing, Mount Kisco, NY, 2000, 271-274
4. Keller BB: Function and biomechanics of developing cardiovascular systems. In Formation of the Heart & Its Regulation. (ed) R Tomanek. Springer-Verlag, 2001,251-271.
5. Keller BB: Practical applications derived from basic studies of developing cardiovascular systems. In Comparative Developmental Physiology: Contributions, Tools and Trends. (eds) SJ Warburton, WW Burggren, B Pelster, CL Reiber and J Spicer. Oxford University Press, Inc, USA, 2006, 148-160.
6. Cai L and Keller BB: Cardiac regeneration and diabetes. Regenerative Medicine Research 2014;2:1 PMID 25984329 PMCID: PMC4422323
BOOKS 1. Burggren WW and Keller BB: Development of Cardiovascular Systems: Molecules to Organisms. Cambridge Univ Press,
New York, 1997, 360 pages.
2. Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagshi H (eds): Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology. Springer Open, 2016, 383 pages.
BOOK CHAPTERS 1. Keller BB: Heart Failure. In Primary Pediatric Care, ed 2; (eds) Hoekelman RA, Friedman SB, Nelson NM, Seidel HM, CV
Mosby Co, St Louis, 1990,pp1620-1621, and ed 3, 1997,pp1713-4. 2. Keller BB. Embryonic Cardiovascular Function, Coupling, and Maturation: A Species View. In Development of
Cardiovascular Systems: Molecules to Organisms. (eds) Burggren W and Keller BB. Cambridge Univ Press, New York, 1997, pp65-87.
3. Keller BB and Markwald RR. Embryonic Structural and Functional Cardiovascular Maturation. In The Heart: Arteries and Veins, ed 9; (eds) Hurst JW, Logue RB, Rackley CE, Schlant RC, Sonnenblick EH, Wallace G, Wenger NK, McGraw-Hill Book Co, New York 1998, 195-221.
4. Keller BB. Analysis of Murine Embryonic Structural and Functional Phenotype. In Cardiovascular Physiology in the
Genetically Engineered Mouse. (eds) Hoit BD and Walsh RA. Kluwer Academic Publishers, New York, 1998;259-280.
5. Keller BB, Wessels A, Schwartz Roberts R, and Markwald RR. Molecular Development and Embryology of the Heart. In Hurst’s the Heart, ed 10; (eds) Fuster, V, Roberts R, Alexander RW O’Rourke RA, King SP III, and Wellens HJJ, McGraw-Hill Book Co, New York 2000,167-192.
6. Tobita K, Tinney J, and Keller BB. Cardiovascular Phenotype Analysis of Murine Embryos. In Cardiovascular Physiology in the Genetically Engineered Mouse, 2nd Edition. (eds) Hoit BD and Walsh RA. Kluwer Academic Publishers, New York 2002, 353-376.
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BOOK CHAPTERS (cont.) 7. Schroder EA, Satin J, Routkevitch S, Tsyvian P, and Keller BB. T-type and L-Type Calcium Currents Modulate Force in
Embryonic Chick Myocardium. In Cardiac Development. (eds) Ostadal B, Nagano M, and Dhalla NS. Kluwer Academic Publishers, Boston 2002, 113-132.
8. Keller BB, Wessels A, and Markwald RR. Molecular Development and Embryology of the Heart. In Hurst’s the Heart, ed 11; (eds) Fuster, V, Roberts R, Alexander RW O’Rourke RA, King SP III, and Wellens HJJ, McGraw-Hill Book Co, New York 2004, 155-180
9. Tobita K, Garrison JB, and Keller BB. Differential effects of cyclic stretch on embryonic ventricular cardiomyocyte and non-cardiomyocyte orientation. In Cardiovascular Development and Congenital Malformations: Molecular and Genetic Mechanisms(eds) Artman M, Benson DW, Srivastava D, Nakazawa M. Blackwell Futura, Malden, MA 2005, 177-179.
10. Keller BB. Physiology and biomechanics of developing cardiovascular systems: expanding frontiers. In Cardiovascular Development and Congenital Malformations: Molecular and Genetic Mechanisms(eds) Artman M, Benson DW, Srivastava D, Nakazawa M. Blackwell Futura, Malden, MA 2005, 180-185
11. Tobita K, Garrison JB, and Keller BB. Three-dimensional fiber architecture of the embryonic left ventricle during normal
development and reduced mechanical load. In Cardiovascular Development and Congenital Malformations: Molecular and Genetic Mechanisms(eds) Artman M, Benson DW, Srivastava D, Nakazawa M. Blackwell Futura, Malden, MA 2005, 186-189
12. Kaushik N, Wessels A, Markwald RR, and Keller BB. Molecular Development and Embryology of the Heart. In Hurst’s
the Heart, ed 12; (eds) Fuster, V, O’Rourke RA, Walsh RA, Wilson PP, McGraw-Hill Book Co, New York 2008, 155-176
13. Keller BB. Genetic and Epigenetic Mechanisms for Congenital Heart Disease. In: Pediatric Heart Disease: A Practical Guide; (eds) Daubeney PE, Rigby M, Niwa K, and Gatzoulis MA, Blackwell Publishing, Edinburgh, UK 2007
14. Burggren W, Chapman K, Keller B, Monticino M, and Torday J. Interdisciplinarity in the Biological Sciences. In: Handbook of Interdisciplinarity. Oxford University Press 2010, 119-132
15. Keller BB, Hoying JA, Markwald RR. Molecular Development of the Heart. In Hurst’s the Heart, ed 13; (eds) Fuster, V,
Walsh RA, Harrington RA, McGraw-Hill Book Co, New York 2011, 172-194 16. Keller BB. Epidemiology and Genetics. In: Pediatric Heart Disease: A Practical Guide; ed 2; (eds) Daubeney PE, Rigby
M, Niwa K, and Gatzoulis MA, Blackwell Publishing, Edinburgh, UK 2012 17. Momoi N, Keller BB, Tobita K. Maternal Caffeine Exposure on Fetal Cardiovascular Function and Growth. In Tea in Health
and Disease Prevention; (ed) Preedy,VR, Academic Press, London, UK, 2012, 1273-1286 18. Keller BB, Ye F, Yuan FP, Trada H, Tinney JP, Walsh KM, Masumoto H. Engineered cardiac tissues generated from
immature cardiac and stem-cell derived cells: Multiple approaches and outcomes, In Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology (eds) Nakaniski T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H. Springer Open, 2016, 329 – 336 https://doi.org/10.1007/978-4-431-54628-3
19. Burggren W, Chapman K, Keller BB, Monticino M, and Torday J. Interdisciplinarity in the Biological Sciences. In:
Handbook of Interdisciplinarity. (eds) Frodeman R, Klein JT, Pacheco RCS. Oxford University Press 2017, 101-113 20. Nakane T, Masumoto H, Keller BB. Human induced pluripotent stem cell-derived engineered cardiac tissues, In Stems
Cells and Tissue Engineering. Intechopen 2018 http://dx.doi.org/10.5772/intechopen.71621 21. Ye F, Setozaki S, Kowalski WJ, Dwenger M, Yuan FP, Tinney JP, Nakane T, Masumoto H, and Keller BB. Progress in
the generation of multiple lineage human-iPSC-derived 3D engineered cardiac tissues for cardiac repair, In Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension (eds) Nakanishi T, Baldwin HS, Fineman S, and Yamagishi H. Springer Open, 2018 (in press).F
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LETTERS TO THE EDITOR
1. Tobita K and Keller BB. Response to comments on embryonic stress-strain measurements. Am J Physiol 2001;281:464-466.
INVITED EDITORIALS
1. Keller BB. Developmental structure-function insights from the Tbxfdel/+ mouse model of Holt-Oram syndrome. Am J Physiol Heart Circ Physiol 2005;289:H975-H976.
2. Keller BB. New insights into the developmental biomechanics of the atrioventricular valves. Circ Res 2007;110:1399-1401. PMID: 17525377 PMCID: N/A
3. Pekkan K, Keller BB. Another tipping point: Biomechanics and cardiovascular developmental biology in the 21st century. In Fetal Hemodynamics, special issue. Cardiovasc Eng and Tech (CVET) 2013
4. Keller BB. Part II. Left-Right Patterning and Heterotaxy Related Disorders. In Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology (eds) Nakaniski T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H. Springer Open, 2016, 47-48
5. Sparks J, Keller BB. Insights into pediatric VAD selection, adverse events, and outcomes – a favorable evolution. ASAIO
J. 2017 Jul/Aug;63(4):371-372. doi: 10.1097/MAT.0000000000000620. PMID: 8657928
Curriculum Vitae -- Bradley B. Keller, MD
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ARTICLES (first or senior author) 1. Keller BB, Mehta AV, Shamszadeh M, Marino TA, Sanchez GR, Huff DS, Dunn JF: Oncocytic Cardiomyopathy of Infancy
With Wolff-Parkinson White Syndrome and Ectopic Foci Causing Tachydysrhythmias in Children. Am Heart J 1987;82-792. PMID: 3310564
2. Keller BB, Hu N and Clark EB: Correlation of Ventricular Area, Perimeter, and Conotruncal Diameter with Mass and
Function in the Stage 12 to 24 Chick Embryo. Circ Res 1990;66:109-14. PMID: 2295133 3. Keller BB, Hu N, Serrino PJ, and Clark EB: Ventricular Pressure-Area Loop Characteristics in the Stage 16 to 24 Chick
Embryo. Circ Res 1991;68:226-231. PMID: 1984865 4. Campbell KA, Hu N, Clark EB, and Keller BB: Analysis of dynamic atrial dimension and function during early cardiac
development in the chick embryo. Ped Res 1992;32:333-337. PMID: 1408472 5. Carstensen EL, Duck FA, Meltzer RS, Schwarz KQ, and Keller BB: Bioeffects in echocardiography. Echocardiography
1992;6:605-623. PMID: 10147799 6. Taber LA, Hu N, Pexieder T, Clark EB and Keller BB: Residual strain in the embryonic ventricle of the stage 16 to 24 chick
embryo heart. Circ Res 1993;72:455-462. PMID: 8418994 7. Keller BB, Hu N, and Tinney JP: Embryonic ventricular diastolic and systolic pressure-volume relation. Cardiology in the
Young 1994,4:19-27 8. Casillas CB, Tinney JP, and Keller BB: Influence of acute alterations in cycle length on ventricular function in the chick
embryo. Am J Physiol 1994;267:H905-911. PMID: 8092294 9. Taber LA, Sun H, Cartmell JS, Clark EB, and Keller BB: Epicardial strains in the stage 16 - 24 embryonic chick ventricle.
Circ Res 1994;75:896-903. PMID: 7923636 10. Hu N, Hansen AL, Clark EB, and Keller BB: Atrial natriuretic peptide reduces diastolic filling in the stage 21 chick embryo.
Ped Res 1995;37:465-468. PMID: 7596686 11. Hu N and Keller BB: Relationship of simultaneous atrial and ventricular pressures in the stage 16 to 27 chick embryo. Am J
Physiol 1995;269:H1359-H1362. PMID: 7485568 12. Bowers PN, Tinney JP, and Keller BB: Nitroprusside selectively reduces ventricular preload in the stage 21 chick embryo.
Cardiovasc Res 1996;31:E132-E138. PMID: 8681337 13. Yoshigi M, Hu N, and Keller BB: Dorsal aortic impedance in the stage 24 chick embryo following acute changes in
circulating blood volume. Am J Physiol 1996;270:H1597-1606. PMID: 8928864 14. Keller BB, MacLennan MJ, Tinney JP, and Yoshigi M: In vivo assessment of embryonic cardiovascular dimensions and
function in day 10.5 To 14.5 mouse embryos. Circ Res 1996;79:247-255. PMID: 8756001 15. Yoshigi M and Keller BB: Linearity of pulsatile pressure–flow relations in the embryonic chick vascular system. Circ Res
1996;79:864-870. PMID: 8831512 16. Yoshigi M and Keller BB: Characterization of the embryonic aortic impedance with lumped parameter models. Am J Physiol
1997;273:H19-H27. PMID: 9249470 17. Babbitt K, Fuller L, and Keller BB: A surface micromachined capacitive pressure sensor for biomedical applications. IEEE
Proceedings #97CH36030, Twelfth Biennial University/Government/Industry Microeletronics Symposium 1997;150-153. 18. Miller CE, Vanni MA, Taber LA, and Keller BB: Passive stress-strain measurements in the stage 16 and stage 18 embryonic
chick heart. JBME 1997;119:445-451. PMID: 9407284
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ARTICLES (first or senior author, continued) 19. Miller CE, Vanni MA, and Keller BB: Characterization of passive embryonic myocardium by quasi-linear viscoelasticity
theory. J Biomech 1997;30:985-988. PMID: 9302625 20. Yoshigi M, Ettel JM, and Keller BB: Developmental changes in flow wave propagation velocity in the embryonic chick
vascular system. Am J Physiol 1997;273:H1523-H1529. PMID: 9321845 21. Keller BB, Yoshigi M, and Tinney JP: Ventricular-vascular uncoupling by acute conotruncal occlusion in the stage 21 chick
embryo. Am J Physiol 1997;273:H2861-H2866. PMID: 9435625 22. Tsyvian PB, Routkevich SM, Protsenko YL, Tsyvian EP, Miller CE, and Keller BB: The role of the intra- and extracellular
sources in “Force-Frequency” relations in the chick embryonic myocardium. Russian J Physiol 1998;84:1402-1411. 23. Furukawa S, MacLennan MJ, and Keller BB: Hemodynamic response to anesthesia in pregnant and nonpregnant ICR mice.
Lab Animal Sci 1998;48:357-363. PMID: 10090043 24. Solovyeva OE, Markhasin VS, Tsyvian PB, and Keller BB: Experimental and theoretical investigation of force-interval
relationships in the developing chick myocardium. Biophysica (Ru) 1999;44:337-349. 25. MacLennan MJ and Keller BB: Murine embryonic umbilical arterial velocity during development and following acutely
increased heart rate. Ultrasound in Med Biol 1999;25:361-370. PMID: 10374980 26. Tobita K and Keller BB: End-systolic myocardial stiffness is a load independent index of contractility in the stage 24 chick
embryonic heart. Am J Physiol 1999;276:H2101-H2108. PMID: 10362693 27. Yoshigi M, Keller BB. Pressure-volume relationships of the embryonic heart analyzed by custom-developed IMAQ image
analysis system [Japanese]. InterLab. 1999;4:58-59. 28. Tobita K and Keller BB: Maturation of end-systolic stress-strain relations in chick embryo myocardium. Am J Physiol
2000;279:H216-H224. PMID: 10899059 29. Yoshigi M, Knott G, and Keller BB: Lumped parameter estimation for the embryonic chick vascular system: a time domain
approach using MLAB. Computer Programs Biomed J 2000;63(1):29-41. PMID: 10927152 30. Tobita K and Keller BB: Ventricular epicardial deformation patterns during normal development and during the development
of left heart hypoplasia in the chick embryo. Am J Physiol 2000;279:H959-H969. PMID: 10993756 31. Tsyvian PB, MarkhasinVS, Solovyeva OE, Rutkevitch SM, Protsenko LL, Artemeva OG, Schroder EA, and Keller BB:
Contraction-relaxation dynamics and mechanical restitution in the developing myocardium of the chick embryo. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova Rossiiskaia Akademiia Nauk. 2001;87:901-910. PMID: 11575123
32. Tobita K, Schroder EA, Tinney JP, Garrison JB, and Keller BB: Regional passive ventricular pressure-strain relations during
development of altered loads in the chick embryo. Am J Physiol 2002;282:H2386-H2396. PMID: 12003850 33. Schroder EA, Tobita K, Tinney JP, and Keller BB: Microtubule involvement in the adaptation to altered mechanical load in
the developing chick myocardium. Circ Res 2002;91:353-359. PMID: 12193469
34. Markhasin VS, Nikitina LV, Routkevich SM, Katsnelson LB, Schroder EA, and Keller BB: Effects of mechanical interaction between two rabbit cardiac muscles connected in parallel. J Gen Physiol 2002;21:277-301. PMID: 12537352
35. Tobita K, Garrison JB, Liu LJ, Tinney JP, and Keller BB: Three dimensional myofiber architecture of the embryonic left
ventricle during normal and development of altered mechanical loads. Anat Rec A Discov Mol Cell Evol Biol 2005;283(1):193-201. PMID: 15678488
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ARTICLES (first or senior author, continued) 36. Lucitti JL, Tobita K, and Keller BB: Arterial hemodynamics and mechanical properties after circulatory intervention in the
chick embryo. J Exp Biol 2005;208(10):1877-1885. PMID: 15879068
37. Sharma SK, Lucitti JL, Nordman C, Tinney JP, Tobita K, and Keller BB: Impact of Hypoxia on Early Chick Embryo Growth and Cardiovascular Function. Pediatr Res 2005;58(4):818-824. PMID: 16327005
38. Manole MD, Hickey RW, Momoi N, Tobita K, Tinney JP, Suciu GP, Johnnides M, Clark RS, and Keller BB: Preterminal
gasping during anoxic arrest increases cardiac function in immature rats. Pediatr Res 2006;60(2):174-179. PMID: 16864699 39. Tobita K, Liu LJ, Janczewski AM, Tinney JP, Nonemaker JM, Augustine S, Stolz DB, Shroff SG, and Keller BB:
Engineered early embryonic cardiac tissue (EEECT) retains proliferative and contractile properties of developing embryonic myocardium. Am J Physiol Heart Circ Physiol 2006;291(4):H1829-H1837. PMID: 16617136
40. Lucitti JL, Visconti R, Novak J, and Keller BB: Increased arterial load alters aortic structural and functional properties
during embryogenesis. Am J Physiol Heart Circ Physiol 2006;291(4):H1919-H1926. PMID: 16648183
41. Furukawa S, Tinney JP, Tobita K, and Keller BB: Hemodynamic vulnerability to acute hypoxia in day 10.5 to 16.5 murine embryos. J Obstet Gynecol Res 2006;33:114-127. PMID: 17441882 PMCID: N/A
42. Keller BB, Liu LJ, Tinney JP, and Tobita K. Cardiovascular developmental insights from embryos. Ann NY Acad Sci
2007;100:1399-1401. PMID: 17303838 PMCID: N/A 43. Emery SP, Kreutzer J, Sherman FR, Fujimoto KL, Jaramaz B, Nikou C, Tobita K, and Keller BB. Computer-assisted
navigation applied to fetal cardiac intervention. Int J Med Rob Comp Asst Surg 2007;3(3):187-198. PMID: 17729376 PMCID: N/A 44. Emery SP, Kreutzer J, McCaffrey F, Sherman FR, Simhan HN, and Keller BB. The learning curve of a fetal cardiac
intervention team. Min Invasive Surg 2010;2010:674185. PMID 22091354 PMCID: PMC3196156 45. Das BB, Christensen J, Brock G, Barnes C, Sobczyk W, and Keller BB. Compaction ratio guidelines in the diagnosis of
isolated left ventricular noncompaction in infants and children. J Kentucky Medical Assoc 2010;110:35-41. 46. Ye F, Yuan FP, Li X, Cooper N, Tinney JP, Keller BB. Gene expression profiles in engineered cardiac tissues respond to
mechanical loading and inhibition of tyrosine kinases. Physiol Reports 2013;1(5):e00078 PMID: 24303162 PMCID: PMC3841024
47. Black AK, Sadanala UK, Mascio CE, Hornung CA, Keller BB. Challenges in implementing a pediatric cardiovascular
home telehealth project. Telemed and E Health 2014;20(9):858-67. PMID: 25083905 PMCID: N/A 48. Masumoto H, Keller BB. Bioengineering for stem cell-based cardiac regeneration. J Stem Cell Res Ther 2014;4:5.
doi:10.4172/2157- 7633.1000200 49. Kowalski WJ, Pekkan K, Tinney JP, Keller BB. Investigating developmental cardiovascular biomechanics and the origins
of congenital heart defects. Frontiers Biophysics 2014;5:4-8. PMID: 25374544 PMCID: PMC4204442 50. Trada H, Vendra V, Tinney JP, Yuan, FP, Jackson D, Walsh K, Keller BB. Implantable thin-film porous microelectrode
array sensor (P-MEA-S) for electrical stimulation of engineered cardiac tissues. BioChip Journal 2015;9(2):85-96. 51. Masumoto H, Nakane T, Tinney JP, Yuan FP, Ye F, Kowalski WJ, Minakata K, Sakata R, Yamashita JK, Keller BB. The
potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages for cardiac regeneration. Scientific Reports 2016; 6:29933. PMID: 27435115 PMCID: PMC4951692
YouTube: https://www.youtube.com/watch?v=dDUtxP-zcP0
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ARTICLES (first or senior author, continued) 52. Nakane T, Masumoto H, Tinney JP, Yuan FP, Kowalski WJ, Ye F, LeBlanc AJ, Yamashita JK, Keller BB. Development
of a large-format engineered cardiac tissue from human induced pluripotent stem cells-derived multiple lineage cardiac cells. Scientific Reports 2017;7:45641. doi: 10.1038/srep45641. PMID: 28368043
53. Kowalski WJ, Yuan FP, Nakane T, Masumoto H, Dwenger M, Ye F, Tinney JP, Keller BB. Quantification of
cardiomyocyte alignment from 3D confocal microscopy of engineered tissue. Microscopy and Microanalysis 2017;23:826-842. doi: 10.1017/S1431927617000666. PMID: 28625174
54. Hu Y, Ye F, Yuan F, Cai L, Ji H, Keller BB. Cardiomyocyte-specific metallothionein overexpression delays Cadmium induced Injury in neonatal murine engineered cardiac tissues. Toxicol Sci 2018,1-13. Doi:10.1093/toxsci/kfy177 PMID: 29982767 55. Kang Y, Wang S, Huang J, Cai L, Keller BB. Right ventricular dysfunction and remodeling in diabetic cardiomyopathy. Am J. Physiology, Heart and Circ Physiol 2018 316(1):H113-H122. doi: 10.1152/ajpheart.00440.2018 PMID: 30412438 56. Dwenger M, Kowalski WJ, Ye F, Yuan F, Tinney JP, Setozaki S, Nakane T, Masumoto H, Campbell P, Guido W, Keller
BB. Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues. J. Tissue Engineering 2019 doi: 10.1177/2041731419841748. PMID: 31024681 57. Hu Y, Zhen J, Xu J, Cai L, Leng Y, Ji H, Keller BB. Metallothieonein dependent and independent zinc mediated protection from cadmium induced toxicity in neonatal murine engineered cardiac tissues. Acta Pharmacologica Sinica (in review) 58. Kang Y, Wang S, Huang J, Cai J, Cai L, Keller BB. Sulforaphane prevents right ventricular injury and reduces pulmonary
vascular remodeling in pulmonary arterial hypertension. Am J Physiology: Heart and Circulatory Physiol (in review).
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ARTICLES (contributing author) 1. Hu N, Connuck D, Keller BB, and Clark EB: Passive and active diastolic ventricular function in stage 12 to 27 chick embryos.
Ped Res 1991;29:334-337. PMID: 1852525 2. Dalecki D, Keller BB, Carstensen EL, Neel DS, Palladino JL, Noordergraaf A: Thresholds for premature ventricular
contractions caused by lithotripter shocks. Ultrasound Med Biol 1991;17:341-346. PMID: 1719683 3. Taber LA, Keller BB, and Clark EB: Cardiac mechanics in the stage 16 chick embryo. J Biomech Eng 1992;114:427-434.
PMID: 1487893 4. Dalecki D, Keller BB, Raeman CH, and Carstensen EL: Effects of pulsed ultrasound on the frog heart: I. Thresholds for
changes in cardiac rhythm and aortic pressure. J Ultrasound Med Biology 1993;19:385-390. PMID: 8356782 5. Ursem NTC, Brinkman HJF, Struijk PC, Hop WCJ, Kempski MH, Keller BB, and Wladimiroff JW. Umbilical artery
waveform analysis based on maximum, mean, and mode velocity in early human pregnancy. Ultrasound Med Biol 1998;24:1-7. PMID: 9483765
6. Ursem NTC, Struijk PC, Hop WCJ, Clark EB, Keller BB, and Wladimiroff JW. Heart rate and flow velocity variability as
determined from umbilical doppler velocimetry at 10-20 weeks of gestation. Clinical Science 1998;95:539-545. PMID: 9791039
7. Ursem NTC, Clark EB, Keller BB, and Wladimiroff JW. Fetal heart rate and umbilical artery velocity variability in pregnancies
complicated by insulin-dependent diabetes mellitus. Ultrasound Obstet Gynecol 1999;13:312-6. PMID: 10380294 8. Ursem NTC, Clark EB, Keller BB, Hop WCJ and Wladimiroff JW. Do heart rate and velocity variability derived from
umbilical artery velocity waveforms change prior to clinical pregnancy induced hypertension? Ultrasound Obstet Gynecol 1999;14:244-9. PMID: 10586475
9. Ursem NTC, Clark EB, Keller BB, Hop WCJ and Wladimiroff JW. Assessment of fetal heart rate and velocity variability by
Doppler velocimetry of the descending aorta at 10-20 weeks of gestation. Ultrasound Obstet Gynecol 1999 14:397-401. PMID: 10658278
10. Cribbs LL, Schroder EA, Keller BB, Delisle BP, and Satin J. Identification of the CaV3.1d gene product in developing
mouse heart: A contributor to embryonic contractility. Circ Res 2001;88:403-407. PMID: 11230107 11. Struijk PC, Ursem NTC, Mathews J, Clark EB, Keller BB , and Wladimiroff JW. Power spectrum analysis of heart rate and
blood flow velocity variability in the umbilical artery and uterine artery in early pregnancy. A comparative study. Ultrasound Obstet Gynecol 2001;17:316-321. PMID: 11339188
12. Sedmera D, Hu N, Weiss KM, Keller BB, Denslow S, and Thompson RP. Cellular changes in experimental left heart
hypoplasia. Anat Rec 2002;267:137-145. PMID: 11997882 13. Chalothorn D, McCune DF, Edelmann SE, Tobita K, Keller BB, Lasley RD, Perez DM, Tanoue A, Tsujimoto G, Post GR,
and Piascik MT: Differential Cardiovascular Regulatory Activities of the Alpha1B- and Alpha1D-Adrenoceptor Subtypes. J Phamacol Exp Ther 2003;305:1045-1053. PMID: 12649302
14. Jeffries JL, Noonan JA, Keller BB, Wilson JF, and Griffith C III: Quality of life and social outcomes in rural adults with
congenital heart disease. Am J Cardiol 2004;94:263-266. PMID: 15246920 15. Law YM, Feingold BM, Keller BB, and Boyle GJ: Use of Plasma B-type Natriuretic Peptide to Identify Ventricular
Dysfunction in Pediatric and Adult Congenital Heart Disease Patients. Am J Cardiol 2005;95:474-478. PMID: 15695131 16. Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tobita K, Keller BB, Cummins JH, and Huard J:
Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Therapy 2005;12(6):1130-1141. PMID: 16125468 PMCID: N/A
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ARTICLES (contributing author, continued) 17. Wearden P, Morell V, Keller BB, Webber SA, Borovetz HS, Badylak SF, Boston JR, Kormos R, Kameneva MV, Simaan
M, Snyder TA, Tsukui H, Wagner WR, Antaki JF, Diao C, Vandenberghe S, Gardiner J, Li CM, Noh D, Paden D, Paden B, Wu J, Bearnson GB, Jacobs G, Kirk J, Khanwilkar P, Long JW, Miles S, Hawkins JA, Kouretas PC, and Shaddy RE. The PediaFlowTM Pediatric Ventricular Assist Device. Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual 2006. (ed) Richard A. Jonas, pp. 92 – 98. PMID: 16638553 PMCID: N/A
18. Borovetz HS, Badylak S, Boston JR, Johnson C, Kormos R, Kameneva MV, Simaan M, Snyder TA, Tsukui H, Wagner
WR, Woolley J, Antaki J, Diao C, Candenberghe S, Keller B, Morell V, Wearden P, Webber S, Gardiner J, Li CM, Paden D, Paden B, Snyder S, Wu J, Bearnson G, Hawkins JA, Jacobs G, Kirk J, Khanwilkar P, Kouretas PC, Long J, and Shaddy RE. Towards the development of a pediatric ventricular assist device. Cell Transplantation 2006;15:S69-S74. PMID: 16826798 PMCID: N/A
19. Fujimoto KL, Tobita K, Merryman DW, Guan J, Momoi N, Stolz DB, Sacks MS, Keller BB, Wagner WR. An elastic,
biodegradable cardiac patch induces contractile smooth muscle and prevents cardiac remodeling in sub-acute myocardial infarction. JACC 2007;49(23):2292-300. PMID: 17560295 PMCID: PMC2857596
20. Payne TR, Oshima H, Okada M, Momoi N, Tobita K, Keller BB, Peng H, Huard J: A relationship between vascular
endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts. JACC 2007;50:1677-1684. PMID: 17950150 PMCID: N/A
21. Pekkan K, Dasi LP, Nourparvar P, Yerneni S, Tobita K, Fogel M, Keller BB, Yoganathan A: In vitro hemodynamic
investigation of the embryonic aortic arch at late gestation. J Biomechanics 2008;41(8):1697-1706. PMID: 18466908 PMCID: PMC3805112 22. Momoi N, Tinney JP, Liu LJ, Elshershari H, Hoffman PJ, Ralphe JC, Keller BB, Tobita K: Modest maternal caffeine
exposure affects developing embryonic cardiovascular function and growth. Am J Physiol Heart Cir 2008;294(5):H2248-56. PMID: 18359892 PMCID: N/A
23. Zahka K, Kalidas K, Cross H, Humbush J, Keller B, Galambos C, Gurtz K, Patton MA, Crosby AH. Homozygous
mutation of MYBPC3 associated with severe infantile hypertrophic cardiomyopathy at high frequency amongst the Amish. Heart 2008;94(10):1326-30. PMID: 18467358 PMCID: N/A
24. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB, Phillippi JA, Peault B, Huard J: Myogenic
endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted myocardium. JACC 2008;52:1869-1880. PMID: 19038685 PMCID: PMC2719893
25. Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith SH, Saba S, Rager J, Conner DA, Janczewski AM, Tobita K, Tinney
JP, Moskowitz IP, Perez-Atayde AR, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG. The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy. PLoS ONE. 2008 Jul 9;3(7):e2642. PMID: 18612386 PMCID: PMC2441440
26. Park TS, Zambidis ET, Lucitti JL, Logar A, Keller BB, Péault B. , Human embryonic stem cell-derived hematoendothelial
progenitors efficiently engraft chicken embryos. Exp Hematol 2009;37(1):31-41. PMID: 17560295 PMCID: N/A 27. Urish KL, Vella JB, Okada M, Deasy BM, Tobita K, Keller BB, Cao B, Piganelli JD, Huard J. Antioxidant levels
represent a major determinant in the regenerative capacity of muscle stem cells. Mol Biol Cell 2009;20(1):509-20. PMID: 19005220 PMCID: PMC2613087
28. Clause KC, Tinney JP, Liu LJ, Keller BB, Tobita K. Engineered early embryonic cardiac tissue increases cardiomyocyte
proliferation by cyclic mechanical stretch via p38-MAP kinase phosphorylation. Tissue Eng Part A 2009;12(6):1373-80. PMID: 19196150 PMCID: PMC2810419
29. Wang Y, Dur O, Patrick MJ, Tinney JP, Tobita K, Keller BB, and Pekkan K. Aortic arch morphogenesis and flow
modeling in the chick embryo. Ann Biomed Eng 2009:37(6):1069-81. PMID: 19337838 PMCID: N/A
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ARTICLES (contributing author, continued) 30. Fujimoto KL, Miki T, Liu LJ, Hashizume R, Strom SC, Wagner W, Keller BB, Tobita K: Naive rate amnion-derived cell
transplantation improved left ventricular function and reduced myocardial scar of post-infarcted heart. Cell Transplantation 2009;18(4):477-86. PMID: 19622235 PMCID: N/A
31. Drowley L, Okada M, Payne T, Botta G, Oshima H, Keller BB, Tobita K, Huard J. Sex of muscle stem cells does not
influence potency for cardiac cell therapy. Cell Transplantation 2009;18(10):1137-1146 PMID: 19523348 PMCID: N/A
32. Clause KC, Tinney JP, Liu LJ, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller BB, Tobita K. A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle derived stem cells. Tissue Eng Part C Methods 2010;16(3):375-85. PMID: 19601695 PMCID: PMC2945363
33. Dur O, Lara M, Arnold D, Vandenberghe S, Keller BB, DeGroff K, Pekkan K. Pulsatile in vitro simulation of the pediatric
univentricular circulation for evaluation of cardiopulmonary assist scenarios. Artif Organs 2009;33:967-976. PMID: 20021470 PMCID: N/A
34. Dur O, DeGroff CG, Keller BB, Pekkan K. Optimization of inflow waveform phase-difference for minimized total
cavopulmonary power loss. J Biomed Eng 2010;132:031012. PMID: 20459200 PMCID: N/A 35. Hashizume R, Fujimoto KL, Hong Y, Amoroso NJ, Tobita K, Miki T, Keller BB, Sacks MS, Wagner WR. Morphological
and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold. Biomaterials 2010;31:3253-65. PMID: 20138661 PMCID: PMC3182828
36. Drowley L, Okada M, Beckman S, Vella J, Keller B, Tobita K, Huard J. Cellular antioxidant levels influence muscle stem
cell therapy. Mol Therapy 2010;18(10):1865-7. PMID: 20664528 PMCID: PMC2951566 37. Abdulkadir AA, Tobita K, Bell MJ, Macpherson TA, Keller BB, Yanowitz TD. Placental maturation and fetal
hemodynamics in a rat model of chorioamnionitis. Ped Res 2010; 68(6):513-518 PMID: 20736882 PMCID: N/A 38. Fujimoto K, Clause KC, Tinney JP, Verma S, Wagner W, Keller BB, Tobita K. Engineered fetal cardiac graft preserves its
cardiomyoctye proliferation within post-infarcted myocardium and sustains cardiac function. Tissue Eng Par A 2011 17:585-96 PMID: 20868205 PMCID: PMC3043979
39. Okada M, Payne TR, Drowley L, Janowski RJ, Momoi N, Beckman S, Chen WCW, Keller BB, Tobita K, Huard J:
Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts. Molecular Therapy 2012;20(1):138-145 PMID: 22068427 PMCID: PMC3255579
40. Cassino TR, Drowley L, Okada M, Beckman SA, Keller B, Tobita K, LeDuc PR, and Huard J. Mechanical loading of stem
cells for improvement of transplantation outcome in a model of acute myocardial infarction: the role of loading history. Tissue Engineering Part A2012;18(11-12):1101-1108. PMID: 22280442 PMCID: PMC3360502
41. Kowalski WJ, Teslovich NC, Dur O, Keller BB, Pekkan K. Computational hemodynamic optimization predicts dominant
aortic arch selection is driven by embryonic outflow tract orientation in the chick embryo. Biomech Model Mechanobiol 2012;11:1057-1073. PMID:22307681 PMCID: N/A
42. Momoi N, Tinney JP, Keller BB, Tobita K: Maternal hypoxia and caffeine exposure depress fetal cardiovascular function
during primary organogenesis. JOGR 2012;38:1343-1351. PMID: 22612345 PMCID: PMC3427416 43. Clause KC, Tchao JS, Powell MC, Liu LJ, Huard J, Keller BB, Tobita K. Developing cardiac and skeletal muscle share
fast-skeletal myosin heavy chain and cardiac troponin-I expression. PLoS ONE 2012;7:e40725. PMID: 22808244 44. Kowalski WJ, Dur O, Wang Y, Patrick MJ, Tinney JP, Keller BB, Pekkan K. Critical transitions in early embryonic aortic
arch patterning and hemodynamics. PLoS ONE 2013;8(3):e60271. PMID: 2355594045. PMCID: PMC3605337
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ARTICLES (contributing author, continued) 45. Nguyen MD, Tinney JP, Yuan FP, Roussel TJ, El-Baz A, Giridharan G, Keller BB, Sethu P. Cardiac cell culture model
(CCCM) as a left ventricular mimic for cardiac tissue generation. Analytical Chemistry 2013;85:8773-8779. PMID: 23952579 PMCID: PMC3822580
46. Wang Y, Loghmanpour NA, Vandenbergh S, Ferrreria A, Keller B, Gorscan J, and Antaki J. Simulation of dilated heart failure with continuous flow circulatory support. PLoS ONE 2014;9:e85234. PMID: 24465511 PMCID: PMC3894974 47. Kowalski WJ, Teslovich NK, Menon PG, Tinney JP, Keller BB, Pekkan K. Left atrial ligation alters intracardiac flow
patterns and the biomechanical landscape in the chick embryo. Dev Dynamics 2014;243:652-662. PMID 24868595 PMCID: PMC4141653
48. Linsky PL, Choi Y, Ouseph R, Slaughter MS, Keller BB, Jones CM. High resolution imaging using the VisualSonics
Vevo2100 on isolated, perfused porcine kidneys on mechanical circulatory support. ASAIO 2014;60:473-478. PMID: 24814832 PMCID: N/A
49. Soucy KG, Smith EF, Monreal G, Rokosh G, Keller BB, Yuan FP, Matheny RG, Fallon AM, Lewis BC, Sherwood LC,
Sobieski MA, Giridharan GA, Koenig SC, Slaughter MS. Feasibility study of particulate extracellular matrix (P-ECM) and left ventricular assist device (HVAD) therapy in chronic ischemic heart failure bovine model. ASAIO 2015;61(2):161-169 PMID: 25423120 PMCID: N/A
50. Nguyen MD, Tinney JP, Ye F, Elnakieb A, Yuan FP, El-Baz A, Sethu P, Keller BB, Giridharan G. Effects of physiologic
mechanical stimulation on embryonic chick cardiomyocytes using a microfluidic cardiac cell culture model. Analytical Chemistry 2015;87:2107-2113. PMID: 25539164 PMCID: PMC4334242
51. Hunter RK, Nevitt CD, Gaskins JT, Keller BB, Bohler HCL, LeBlanc AJ. Adipose-derived stromal vascular fraction cell
effects on a rodent model of thin endometrium. PLoS One 2015;10(12):e0144823. PMID: 26657744 PMCID: PMC4684382 52. Dydynski PB, Kiper C, Kozik D, Keller BB, Austin E, Holland B. 3-dimensional reconstruction of intracardiac anatomy
using CT angiography and surgical planning for double outlet right ventricle: early experience at a tertiary care congenital heart center. World J Pediatr Congenit Heart Surg 2016;7(4):467-74. PMID: 27358302
53. Goktas S, Uslu FE, Kowalski W, Ermek E, Keller BB, Pekkan K. Time-series interactions of gene expression, vascular
growth and hemodynamics during early embryonic arterial development. PLoS One. 2016:11(8):e0161611. PMID: 27552150
54. DeVeau KM, Martin EK, King NT, Shum-Siu A, Keller BB, West C, and Magnuson DSK. Challenging cardiac function
post-spinal cord injury with Dobutamine. Auton Neurosci: Basic and Clinical 2016;S1566-0702(16)30286-7 PMID: 28065654 PMCID: PMC5481490
55. Gu J, Cheng Y, Wu H, Kong L, Wang S, Xu Z, Zhang Z, Tan Y, Keller BB, Zhou H, Wang Y, Xu Z, Cai L.
Metallothionein is downstream of Nrf2 and partially mediates sulforaphane prevention of diabetic cardiomyopathy. Diabetes 2017;66(2):529-542. doi: 10.2337/db15-1274. PMID: 27903744
56. Qian LB, Jiang SZ, Tang XQ, Zhang J, Liang YQ, Chen J, Xu Z, Liu RM, Keller BB, Ji HL, Cai L. Exacerbation of
diabetes-induced cardiac hypertrophy in OVE26 mice by acute, subpressor angiotensin II is associated with JNK/c-jun/miR-221-mediated autophagy inhibition. Oncotarget J 2017;8(63):106661-106671. doi: 10.18632/oncotarget.21302
PMID: 29290979 PMCID: PMC5739764 57. Gu J, Wang S, Guo H, Tan Y, Liu Q, Zhang Z, Keller BB, Zhang C, Cai L. Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolytic, and impaired angiogenesis. Cell Death and Disease 2018 Jan 23;9(2):82. doi: 10.1038/s41419-017-0093-5. PMID: 29362483
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ARTICLES (contributing author, continued) 58. Kelm N, Beare J, Yuan F, George M, Shofner C, Keller BB, Hoying JB, LeBlanc A. Adipose-derived cells improve left ventricular diastolic function and increases microvascular perfusion in advanced age. PLoS ONE 2018; 13(8):e0202934. doi: 10.1371/journal.pone.0202934. PMID: 30142193 59. Karakaya C, Goktas S, Celik M, Kowalski WJ, Keller BB, Pekkan K. Symmetry in mechanosensitive gene expression during aortic arch morphogenesis. Sci Reports 2018; 8(1):16948. PMID: 30446764 DOI: 10.1038/s41598-018-35127-7 60. Pandit H, Tinney JP, Li Y, Li S, Keller BB, Martin RCG II. Utilizing contrast-enhanced ultrasound imaging for evaluating fatty liver disease progression in preclinical mouse models. Ultrasound Med Biol 2019 Feb;45(2):549-557. doi: 10.1016/j.ultrasmedbio.2018.10.011. PMID: 30527843 61. Tan Y, Zhang Z, Zeng C, Wintergerst KA, Keller BB, Cai L. Mechanistic insights into the development of diabetic
cardiomyopathy: Preclinical and clinical evidence. Nature Reviews Cardiology (NRCAR-18-010V1, revised, in review). 62. Xu Z, Gatzoulis MA, Dimopoulos K, Li Q, Liu Q, Fu X, Keller BB, Gu H. Better outcomes in patients with pulmonary
arterial hypertension after repair of congenital heart disease compared with idiopathic pulmonary arterial hypertension. Am J Cardiology (in review).
63. Guo B, Li Q, Keller BB, Gu H. Anomalous origin of the common coronary artery from the pulmonary artery: a rare case.
Pediatric Cardiology (in review).
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P. LECTURES Date Title and Institution October, 1989 Ventricular Mechanics in the Chick Embryo, Children's Memorial Hospital, Chicago, IL. March, 1990 Diagnosis and Management of Heart Failure in Children, Pediatric Grand Rounds, Belle Glade, FL. September, 1990 Ventricular Mechanics in the Developing Heart, Strong Children's Research Center, Rochester, NY. July, 1991 Biomechanics of the Developing Cardiovascular System, Japan Heart Institute, Tokyo Women's Medical College, Tokyo, Japan. September, 1991 Embryonic and Fetal Cardiovascular Mechanics. Northeast Ped. Cardiology Society, Hyannis, MA August, 1992 Fetal Cardiovascular Screening. Grand Rounds, Department of Obstetrics and Gynecology, The Genesee Hospital, Rochester, NY. June, 1993 Embryonic Cardiovascular Structural and Functional Maturation, Complutense Univ., Madrid, Spain November, 1993 Cardiovascular Structural and Functional Maturation. University of South Carolina, Columbia, SC. November, 1993 Embryonic Integrated Physiology, Engineering, and Mechanics. Kyoto Prefectural University, Kyoto, JAPAN. January, 1994 Tetralogy of Fallot: An Example of Congenital Heart Disease in Evolution. Grand Rounds, Dept of Pediatrics, University of Rochester, Rochester, NY May, 1994 Tetralogy of Fallot: Clinical and Basic Science Advances. 75th annual meeting of the Central New York Pediatric Club, New Hartford, NY. November, 1994 Embryonic Cardiovascular Maturation. Burgher Cardiovascular Institute. UCSD, La Jolla, CA. November, 1994 Embryonic Structural and Functional Maturation. Spontaneous Comparative Physiology Workshop, UNLV, Las Vegas, NV December, 1994 Cardiac Developmental and Mechanical Forces. NIH SCOR in Neonatology, Department of Pediatrics, University of Rochester, NY. August, 1995 Avian and Mammalian Embryonic Cardiovascular Function. Perinatal Cardiology Conference, Pennsylvania Hospital, Philadelphia, PA. August, 1995 Normal and Experimentally Altered Embryonic Cardiovascular Function. Perinatal Management Conference, Pennsylvania Hospital, Philadelphia, PA. August, 1995 Normal and Experimentally Altered Embryonic Cardiovascular Function. Dept of Cell Biology, Univ. Med. and Dent. of New Jersey, Stratford, NJ. October, 1995 Cardiovascular Embryology and Physiology. Fetal Echocardiography Program. The Jefferson Feb and Sept, 1996 Ultrasound Research and Education Institute and Pennsylvania Hospital, Philadelphia, PA. Feb and Oct, 1997 March, 1996 Novel Approaches in the Experimental Investigation of Cardiovascular Development: Chick, Mouse, and Human. Reproductive/Development Workshop, University of Rochester. April, 1996 Tetralogy of Fallot: Past, Present, and Future Challenges. Cardiology Update 1996, American Heart Association Long Island Affiliate, Mineola, NY.
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LECTURES (continued) October, 1996 Physiologic and Engineering Investigation of Cardiovascular Development. Ural Branch, Russian Academy of Science, Yekaterinburg, Russia. January, 1997 Tetralogy of Fallot -From Bench to Bedside. Department of Pediatrics Grand Rounds, New York University Medical Center, New York, NY. January, 1997 Embryonic Cardiovascular Physiology, Evolving Strategies. Department of Pediatrics, Division of Pediatric Cardiology, NYU Medical Center, New York. March, 1997 Cardiovascular Physiology and Mechanics in the Embryo. Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC. April, 1997 Tetralogy of Fallot - At the Leading Edge. Department of Pediatrics Grand Rounds, New York Medical College, Valhalla, NY. April, 1997 Physiology and Mechanics of the Developing Myocardium. Physiology Department Grand Rounds, New York Medical College, Valhalla, NY. July, 1997 Physiology and Mechanics in the Developing Cardiovascular System. Departments of Pediatrics, Rainbow Babies Childrens Hospital, Cleveland, OH. February, 1998 Congenital Cardiovascular Malformations: New Ideas About Old Problems. Regional Mother and Child Hospital, Yekaterinburg, Siberia, Russia. March, 1998 Integrated Embryonic Cardiovascular Physiology and Mechanics, Japan Heart Institute, Tokyo Women's Medical College, Tokyo, Japan. April, 1998 Tetralogy of Fallot - Bedside to Bench. Department of Pediatrics Grand Rounds, State Univ. of New York, Winthrope Univ Hospital, Mineola, NY June, 1998 Dysrhythmias in the Newborn. 18th Annual Townsend Teaching Day in Neonatal/Perinatal Medicine, Rochester General Hospital, Rochester, NY. October, 1998 Approaches to Mend the Broken Heart. Department of Pediatrics Grand Rounds. University of Kentucky, Lexington, KY. January, 1999 Function, Biomechanics and Control of Developing Cardiovascular Systems. University of Arizona, Department of Biomedical Engineering, Tucson, AZ. March, 1999 Function and Biomechanics of the Developing Heart. Department of Physiology Lecture Series. University of Kentucky, Lexington, KY. April, 1999 Congenital Heart Disease in Adulthood. 2nd Coronary Valley Symposium, Radison Hotel, Lexington, KY. April, 1999 Pediatric Cardiology Update. Department of Pediatrics, Central Baptist Hospital, Lexington, KY. May, 1999 Common Pediatric Cardiology Dilemmas, Contemporary Pediatrics for the Practicing Physician Conference, Lexington, KY. October, 1999 News from the First Noonan Congenital Cardiovascular Symposium, Department of Pediatrics Grand Rounds. University of Kentucky, Lexington, KY. November, 1999 Cardiovascular Screening of the Young Athlete. First Annual Pikeville College School of Osteopathic Medicine Pediatric Symposium, Pikeville, KY.
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LECTURES (continued) November, 1999 Basic Approaches in Ambulatory Pediatric Cardiology. Lake Cumberland Regional Nursing Continuing Medical Education Conference, Somerset, KY. December, 1999 Embryonic Cardiovascular Structure-Function Paradigms: Insights into Normal Development and Congenital Cardiovascular Malformations. Samuel Lunenfeld Research Institute, University of Toronto, Canada. March, 2000 Clinical and Basic Science Advances in Congenital Heart Disease, Department of Emergency Medicine Grand Rounds, Lexington, KY. May, 2000 Structure-Function Paradigms in Developing Cardiovascular Systems. The Institute for Child Health, Great Ormond Street, London, England. May, 2000 Structure-Function Paradigms in Developing Cardiovascular Systems. The National Heart and Lung Institute at the Brompton Hospital, London, England. January, 2001 Profiles in Aortic Valve Disease: Natural and Unnatural Histories. Department of Pediatrics Grand Rounds. University of Kentucky, Lexington, KY. June, 2001 New Horizons in Pediatric Cardiovascular Diseases for the 21st Century. New Horizons in Fetal Cardiology. The National Heart and Lung Institute at the Brompton Hospital, London. October, 2001 Structure, Function, and Adaptation of Developing Cardiovascular Systems: Insights from Embryos. University of Pittsburgh, Pittsburgh, PA. January, 2002 Basic Approaches to the Spectrum of Pediatric Arrhythmias. Department of Pediatrics Grand Rounds. University of Kentucky, Lexington, KY. January, 2002 Insights into Cardiovascular Malformations Learned from the Embryo. Gill Cardiovascular Research Symposium, University of Kentucky, Lexington, KY. December, 2002 Physiology and Biomechanics of Developing Cardiovascular Systems from Embryo to Adult. Department of Pediatric Cardiology, Kyoto Prefectural University, Kyoto, JAPAN. January, 2003 Physiology and Biomechanics of Developing Cardiovascular Systems: From Embryo to Adult. Department of Pediatrics Research Conference, Children’s Hospital of Pittsburgh, Pittsburgh, PA. April, 2003 Physiology and Biomechanics of Developing Cardiovascular Systems: Research Overview. Magowan Institute of Regenerative Medicine Seminar Series, University of Pittsburgh, Pittsburgh, PA. June, 2003 Innovations in the Diagnosis and Management of Congenital Heart Disease. Department of Pediatrics Grand Rounds, Children’s Hospital of Pittsburgh, Pittsburgh, PA
March 2004 Fetal Cardiovascular Malformations: Novel Approaches to Pathogenesis and Intervention. Department of Obstetrics and Gynecology Grand Rounds, Magee Womens Research Institute, Pittsburgh, PA
March 2004 Congenital Cardiovascular Malformations in Adults - the Developmental Perspective. Cardiovascular Institute Grand Rounds, Department of Medicine, University of Pittsburgh, Pittsburgh, April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult: Part I – Developmental
Mechanisms. 3rd Five-Continent International Symposium on Cardiovascular Diseases and 20th Anniversary Celebration of the Founding of Anzhen Hospital, Beijing, China
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LECTURES (continued) April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult: Part II – Clinical
Applications. 3rd Five-Continent International Symposium on Cardiovascular Diseases and 20th Anniversary Celebration of the Founding of Anzhen Hospital, Beijing, China
April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult. Department of Pediatric
Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
March 2005 Physiology and Biomechanics of Developing Cardiovascular Systems: Insights from Embryos. Department of Pediatrics Combined Allergy/Immunology Conference, Children’s Hospital of Pittsburgh, Pittsburgh, PA
October 2005 Evolution in the Assessment of Embryonic Ventricular Function. Department of Obstetrics and
Gynecology, Erasmus University, Rotterdam, the Netherlands March 2007 Insights From Embryos on Cardiovascular Morphogenesis, Adaptation, and Repair. University of
Pittsburgh Graduate School of Public Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA
April 2007 Mending the Broken Embryonic Heart. 2007 Annual Science Lecturer. Heart Research Center.
Oregon Health & Science University, Portland, OR April 2007 Genetic Mechanism of Congenital Cardiovascular Malformations. Fellow’s Conference. Division of
Pediatric Cardiology, Department of Pediatrics. Oregon Health & Science University, Portland, OR June 2007 Update on Maternal-Embryonic Cardiovascular Coupling. Samuel Lunenfeld Research Institute,
University of Toronto, Canada. February 2008 Insights from Embryos on How to Repair a Broken Heart. Department of Pediatrics. Yale School of
Medicine, Yale New Haven Children’s Hospital, New Haven, CT. April 2008 Congenital Heart Disease: Engineering Challenges and Opportunities. Surgery for Engineers
Course, Carnegie Mellon University, Pittsburgh, PA. January 2009 Molecular Biology and Bioengineering Insights into How to Repair a Broken Heart. Neonatology
Grand Rounds. Magee-Women’s Hospital of UPMC, Pittsburgh, PA. January 2009 Molecular Biology and Bioengineering Insights into How to Repair a Broken Heart. Department of
Pediatrics, Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY October 9, 2009 Pediatric Cardiology in Emerging Nations. 7th Annual Cardiovascular Diseases and Stroke
Symposium. Louisville, KY April 9, 2010 Insights into the Causes and Treatments of Congenital Heart Disease with an Update on High
Resolution Ultrasound Imaging for Humans. Christine M. Kleinert Institute for Hand and Microsurgery, Louisville, KY
July 8, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Department of
Pharmacology and Toxicology, University of Louisville, Louisville, KY October 19, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Frontier
Lifeline Hospital and the K.M. Cherrian Heart Foundation, Chennai, India November 5, 2010 Insights from Embryos into Cardiac Morphogenesis and Repair. 2010 Carolina Cardiovascular
COBRE Conference, University of South Carolina, Columbia, SC
Curriculum Vitae -- Bradley B. Keller, MD
53 Updated: June 19, 2019
LECTURES (continued) December 13, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Department
of Pediatrics, University of Louisville, Louisville, KY March 14, 2010 Asking and Answering Pediatric Relevant Research Questions. Department of Pediatrics, University
of Louisville, Louisville, KY April 14, 2011 Insights from Embryos into Cardiac Morphogenesis and Repair. 9th Annual Spring Symposium of
the Cardiovascular Developmental Biology Center (CDBC): Formation and Remodeling of the Cardiovascular System in Health and Disease. Medical University of South Carolina, Charleston,SC
September 10, 2011 Expanding our Understanding and Treatment of Heart Disease in Children. Kosair Charities Annual
Luncheon, Louisville, KY March 28, 2012 Congenital Heart Disease from the Embryo through Adulthood: New Insights, Novel Treatments,
and Continued Challenges. Cardiology Grand Rounds, Rudd Heart and Lung Institute, University of Louisville, Louisville, KY
September 4, 2012 Establishing Successful Provider-Patient Interactions. Adult Cardiology Post-Doctoral Fellowship
Training Course. Department of Medicine, University of Louisville, Louisville, KY September 5, 2012 High Resolution Imaging for Neonates: Progress Report Using the VisualSonics Vevo2100 in humans. Neonatology Research Conference, University of Louisville, Louisville, KY September 17, 2012 Our Expanding Pediatric Research Enterprise: Part I. Monthly Research Conference. Department of Pediatrics, University of Louisville, Louisville, KY November 27, 2012 Pediatric Congenital Heart Disease: Innovations Improving Outcomes. Kosair Charities Donors,
Kosair Charities Campus, Louisville, KY July 15, 2013 Engineered cardiac tissues generated from immature cardiac and stem-cell derived cells: Multiple
approaches and outcomes. 7th International Takao Symposium: Congenital Heart Disease from Genes to Morphology. Tokyo, Japan
July 18, 2013 Congenital Heart Disease from the Embryo through Adulthood: New Insights, Novel Treatments,
and Continued Challenges. Department of Pediatric Cardiology. National Cardiovascular Center, Osaka, Japan
July 23, 2013 Insights from cardiovascular morphogenesis in embryos guide cardiac repair. Department of
Cardiovascular Surgery, Kyoto University Hospital and the. Laboratory of Stem Cell Differentiation, CIRA/Institute for Frontier Medicine, Kyoto, Japan
September 6, 2013 How Our Expanding Pediatric Research Enterprise is Transforming Care. Department of Pediatrics Grand Rounds, University of Louisville, Louisville, KY September 24, 2013 Introducing our Clinical, Educational, and Research Programs at the University of Louisville.
1st Affiliated Hospital; 2nd Affiliated Hospital and the Yuying Children’s Hospital; and the School of Pharmacy, Wenzhou Medical University, Wenzhou, China
September 26, 2013 Introducing our Clinical, Educational, and Research Programs at the University of Louisville.
Jiangxi Provincial Children’s Hospital, Nanchang, China
September 29, 2013 Introducing our Clinical, Educational, and Research Programs at the University of Louisville. 1st Affiliated Hospital; and the Department of Pediatrics, Jilin University, Changchun, CHINA
Curriculum Vitae -- Bradley B. Keller, MD
54 Updated: June 19, 2019
LECTURES (continued) November 5, 2013 Insights into Research Proposal Preparation and Review: the Good, the Bad, and How to Survive. Department of Pediatrics Faculty Development Seminar Series, Univ. of Louisville, Louisville, KY December 9, 2013 Chinese American Collaborative Research Opportunities (presented with Dr. Lu Cai, KCHRI
Director). Monthly Research Conference. Department of Pediatrics, University of Louisville, Louisville, KY
February 26, 2014 Congenital Heart Disease: Origins and Innovations. American Heart Association, Kentucky
Chapter, Donor Meeting, Kentucky Science Center, Louisville, KY March 31, 2014 Expanding the Spectrum of High Resolution Ultrasound Imaging from Embryos to Neonates. 2014 American Institute of Ultrasound in Medicine Annual Meeting, Las Vegas, NV May 29, 2014 Functionalized Tissue Engineered Patches for Pediatric Cardiovascular Reconstructions. The
10th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion. Children’s Hospital of Philadelphia, Philadelphia, PA February 13, 2015 Innovations in Pediatric Cardiovascular Research at the University of Louisville. Department of Pediatrics Grand Rounds, University of Louisville, Louisville, KY March 24, 2015 Introduction to NIH Grants – Programs and Strategies. Faculty Development Seminar, Department
of Pediatrics, University of Louisville, Louisville, KY April 7, 2015 Recent Progress in Generating Engineered Cardiac Tissues for Cardiac Restoration. Department of
Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA June 15, 2015 Congenital Heart Disease: Origins and Innovations. Kentuckiana Chapter, Mended Hearts,
Baptist Hospital East, Louisville, KY October 28, 2015 Insights from Embryos and Engineered Tissues on Cardiac Development and Repair. Shanghai
Chest Hospital, Shanghai, China
November 1, 2015 Insights into the Origins and Novel Treatments for Children and Adults with Congenital Heart Disease. 2015 Yuying Forum�International Conference on Translational Medicine, Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China
January 11, 2016 Engineered Cardiac Tissues from Human Stem Cells. Monthly Research Conference, Department
of Pediatrics, University of Louisville, Louisville, KY (presented with Dr. Take Nakane) January 23, 2017 Updated on Engineered Cardiac Tissues for Cardiac Repair. Monthly Research Conference,
Department of Pediatrics, University of Louisville, Louisville, KY March 15, 2017 Developmental Biomechanics and Stem Cell Biology Applied to Cardiovascular Disease Modeling
and Repair. Work in Progress Seminar, Pediatric Research Institute, University of Louisville, Louisville, KY
April 11, 2017 Update on our UofL-China Pediatric Research Exchange Program. 1st Affiliated Hospital and the
Department of Pediatrics, Jilin University, Changchun, China April 14, 2017 Stem Cell Biology Applied to Cardiovascular Disease Modeling and Repair.1st Affiliated Hospital
and the School of Pharmacy, Wenzhou Medical University, Wenzhou, China April 15, 2017 Update on our UofL-China Pediatric Research Exchange Program. 3rd Affiliated Hospital,
Wenzhou Medical University, Riuan, China
Curriculum Vitae -- Bradley B. Keller, MD
55 Updated: June 19, 2019
LECTURES (continued) April 17, 2017 Update on our UofL-China Pediatric Research Exchange Program. Jiangxi Provincial Children’s
Hospital, Nanchang, China June 3, 2017 Career Options and Opportunities as Physician-Scientist. 2017 Youth Science Summit.
Cardiovascular Innovation Institute, Louisville, KY October 8, 2017 Progress in the Generation of Multiple Lineage Human iPSC-Derived 3D Engineered Cardiac Tissues for Tissue Repair. Invited Lecture, the 8th Takao International Symposium on Molecular Mechanisms of Cardiopulmonary Disease. Matsue, Japan. August 18, 2018 Update on 3D Engineered Cardiac Tissues: new mouse ECT model and initial results on
metallothionein overexpression and Cadmium toxicity. Work in Progress Seminar presented with Dr. Haitao Yu, Pediatric Research Institute, University of Louisville, Louisville, KY
October 19, 2018 3D Engineered Cardiac Tissues: A robust in vitro model to investigate myocardial injury and
recovery. School of Public Health, Wenzhou Medical University, Wenzhou, China
October 20, 2018 3D Engineered Cardiac Tissues: A robust in vitro model to investigate myocardial maturation, injury, and recovery. 9th Chinese-American Diabetic Complication Forum. Rui’An People’s Hospital and the Third Hospital Affiliated to Wenzhou Medical University, Rui’An, China
October 23, 2018 University of Louisville and Jilin University Research Training Exchange Program: Update and
Forward Vision. 1st Affiliated Hospital, Jilin University, Changchun, China October 26, 2018 University of Louisville and Jiangxi Provincial Children’s Hospital Research Training Exchange
Program: Update and Forward Vision. Jiangxi Provincial Children’s Hospital, Nanchang, China November 14, 2018 Congenital Heart Disease from the Embryo through Adulthood: A Broad Perspective for Residents.
Department of Pediatrics, University of Louisville, Louisville, KY February 20, 2019 Initial Findings using a Mouse Model of Pulmonary Arterial Hypertension (PAH): Sulforaphane
Improves Right Ventricular Function and Reduces Pulmonary Vascular Remodeling. Work in Progress Seminar presented with Dr. Yin Kang, Pediatric Research Institute, University of Louisville, Louisville, KY
April 11, 2019 Clinical Management of the Dizzy Child and Update on the New Novak Center for Children’s
Health. Central Kentucky Pediatric Care Symposium, Campbellsville, KY May 6, 2019 Overview of Mechanical Assist Device, Tissue Engineering, and Pulmonary Hypertension Research
at the Cardiovascular Innovation Institute at UofL. Tianjin Cardiovascular Research Institute, Tianjin, China
May 9, 2019 Innovations in the Management of Congenital Heart Disease. Combined Cardiovascular Surgery,
Anesthesia, and Critical Care Conference. Guangdong General Hospital, Guangzhou Cardiovascular Institute, Guangzhou, China
May 11, 2019 Strategies to Protect the Vulnerable Right Ventricle in Diabetes. 10th Chinese-American Diabetic
Complication Forum. Rui’An People’s Hospital and the Third Hospital Affiliated to Wenzhou Medical University, Rui’An, China