curriculum vitae - bch.cuhk.edu.hk...curriculum vitae dr. christina fung ping leung email:...

Curriculum vitae

Dr. Christina Fung Ping LEUNG

Email: [email protected]

RESEARCH INTERESTS

(1) Endothelial dysfunction in hypertension, diabetes and estrogen deficiency;

(2) Hypotensive and antioxidant actions of biologically active components of Traditional Chinese

Medicine and natural compounds;

(3) Calcium, Nitric oxide and/or Reactive oxygen species imaging in smooth muscle and endothelium,

mast cells, cardiac cells and embryonic stem cells;

(4) Calcium Signaling in Muscle development using zebrafish as animal model;

(5) Proteomic and metabolomics studies in inflammatory bowel diseases and irritable bowel

syndrome (IBS);

(6) Drug discovery and therapeutics.

CURRENT POSITIONS AND PROFESSIONAL HISTORY, EXPERIENCE & SERVICES

Senior Research Scientist, School of Life Sciences, Hong Kong University of Science &

Technology, 2017.9- Present

Conference Secretariat in charge of organizing the NSFC/RGC Conference: Cardiovascular

Calcium Signaling Pathway Role in Health and Disease.

Conference webpage: http://www.cvcs-hk.org

Lecturer, Higher Diploma in Biomedical Science/Medical Laboratory Science, Shatin IVE

2015-2017.8

Teaching diverse subjects such as Biochemistry, Public Health, Human Anatomy, Clinical

lab instrumentation, Cell Biology, Histology and Dermato-cosmetology, Food

Microbiology, Medical Genetics and Final Year Projects (Forensic science, An exploratory

study of Induced Pluripotent Stem cells) and Industrial attachments.

Total number of subjects: 10 Total workload: 450 hours (AY 15/16)

396 hours (AY 16/17)

Research Assistant Professor, Hong Kong Baptist University 2011-2015

In charge of laboratory management for 4 years.

Supervised post-doctoral fellows, PhD candidates and research assistant.

Participated in undergraduate taught courses including paternity test, genomics,

proteomics, forensic sciences, genetic engineering and biotechnology, cardiovascular

physiology and biochemistry (carbohydrate metabolism, fatty acid oxidation, amino acid

oxidation, lipid biosynthesis etc), and animal physiology.

Involved outcome-based teaching and learning task force and set up rubrics system for student

evaluation.

Developed a new “Life Style Medicine” elective course in School of Chinese Medicine, HKBU.

http://www.cvcs-hk.org/

Fung Ping Leung, Ph.D

2

Involved in various research fields and publish papers including cancer research, Constipation,

Inflammatory Bowel Disease, Drug screening, Hypertension, Menopause, Vascular Medicine.

Involved in supervision of post-doctoral research fellows, research assistants and PhD students.

I also used problem based learning (PBL) to teach undergraduate students.

Lecturer, Prince of Wales Hospital, Chinese University of Hong Kong 2004

Participated in Teaching Master Course ‘Programme in Stroke & Clinical Neurosciences

(CNS)’

Teaching Assistant, Hong Kong University of Science & Technology 1998 -2003

Hall tutor (6 years), Hong Kong University of Science & Technology 1998- 2003

EDUCATION

MSc in Medical Laboratory Sciences 2014.9-present

Department of Health Technology and Informatics, Hong Kong Polytechnics

Practical Chinese Pharmacy 2003.8 -2003.9

School of Continuing Studies, Chinese University of Hong Kong

PhD in Biology 2000.9-2003.7

Hong Kong University of Science and Technology

Mentor: Prof. Miller AL

MPhil in Biology 1998.9-2000.7


Mentor: Prof. Miller AL

BSc in Biology 1996.9-1998.7


RESEARCH AND TEACHING POSITIONS

Lecturer 2015.9-2017.8

Higher Diploma in Biomedical Sciences/Medical Laboratory Science

Sha Tin Institute of Vocational Education

Programmer Leader: Dr. Szeto Yim-tong, PhD

Research Assistant Professor 2011.2-2015.8

School of Chinese Medicine,

Hong Kong Baptist University

Mentor: Bian Zhao Xiang, Ph.D

Postdoctoral Research Fellow 2009.5-2011.1


3

Department of Physiology,

Faculty of Medicine,

The University of Hong Kong

Mentor: Lee Hon Cheung, Ph.D

Postdoctoral Research Fellow and Research Associate 2003.10-2009.4

Department of Physiology, School of Medicine,

Chinese University of Hong Kong

Mentor: Yu Huang, Ph.D

Research Assistant 1998.9-1999.8

Department of Biology

Hong Kong University of Science & Technology

Mentor: Miller AL, Ph.D

COMMUNITY SERVICE

Reviewer 2009-Present

Clinical and Experimental Pharmacology and Physiology

PLOS ONE

Biochemical Pharmacology

Life Sciences

Membership for Professional Society 2004-Present

American Heart Association, USA

Asian Society for Vascular Biology, Hong Kong

Hong Kong Institute of Cardiovascular Science and Medicine, Hong Kong

Hong Kong Pharmacology Society, Hong Kong

RESEARCH GRANTS

Hong Kong Research Grant Council General Research Fund (GRF) Principal Investigator

Theaflavins ameliorate endothelial dysfunction in estrogen deficiency through PPAR activation

Amount: $ 850,000 Duration: 2012.10-2015.3

Hong Kong Health and Health Services Research Fund (HHSRF) Co-Investigator

Synergism of berberine and 5-aminosalicylate (5-ASA) against experimental ulcerative colitis

and its potential mechanisms

Amount: $ 939,936 Duration: 2012.10-2014.10

国家自然科学基金 (NSFC) Co-Investigator

基于靶向代谢组学探究广藿香活性成分治疗炎症性肠病的作用和机理

Amount: $230,000 Duration: 2014.10-2016.10


4

Hong Kong Baptist University Start up Research fund Principal Investigator

Amount: $150,000

Hong Kong Baptist University Faculty Research Grant Co-Investigator

Raloxifene and estrogen block oxidative stress (HXXO)-induced alterations in the proteome of

prostate endothelial cells

Amount: $100,000 Duration: 2012.10-2013.10

The University of Hong Kong Small Project Fund Principal Investigator

Amount: $100,000 Duration: 2009.5-2011.1

HONORS AND AWARDS

Research Merit Award 2006

School of Medicine, Chinese University of Hong Kong

Research Merit Award 2005


Postdoctoral Fellowship 2005






Hong Kong University Grant Committee Research Travel Grant 2001

Conference attendance at the 14th International Congress of Developmental biology

International Student Fellowship 2000

Neural Development and Genetics of Zebrafish” course at Marine Biology

Laboratory, Massachusetts, USA

Hong Kong University Grant Committee Research Travel Grant 2000

PUBLICATIONS & BOOK CHAPTERS

Google scholar citations: 1812

H-index: 24

Peer-reviewed Research Publications (include papers, review articles and book chapters): 52


5

1. Cheang WS, Ngai CY, Tian XY, Tam YY, Zhang Y, Lau CW, Bian ZX, Huang Y, Leung FP(*).

(2015) Black tea protects against hypertension-associated endothelial dysfunction through

alleviation of ER stress. Sci Rep. 2015 May 15;5:10340.

IF: 5.578 - Rank: 5th/55 Journals (Multidisciplinary Science)

2. Leung FP, Yung LM, Yuen NC, Cheang WS, Tian XY, Lau CW, Zhang Y, Liu J, Bian ZX, Huang

Y. (2015) Chronic black tea consumption improves endothelial function in ovariectomized rats.

European Journal of Nutrition

IF: 3.84 - Rank: 17th/79 Journals (Nutrition & Dietetics)

3. Xiao HT, Peng J, Hu DD, Lin CY, Du B, Tsang SW, Lin ZS, Zhang XJ, Leung FP, Han QB, Bian

ZX. (2015) Qing-dai powder promotes recovery of colitis by inhibiting inflammatory responses of

colonic macrophages in dextran sulfate sodium-treated mice. Chin Med. 2015 Oct 13;10:29.

IF: 1.064 - Rank: 45th/79 Journals (Nutrition & Dietetics) Google citation: 2

4. Zhang M, Luo JL, Leung FP, Huang Y, Lin CY, Bian ZX (2013) Magnolol inhibits colonic

motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth

muscle cells in rats. Phytomedicine. 20(14):1272-9.

IF: 2.877 - Rank: 2th/22 Journals (Integrative & complementary medicine) Google citation: 2

5. Law SK, Leung CS, Yau KL, Tse CL, Wong CK, Leung FP, Mascheck L, Huang Y, Sauer H,

Tsang SY. (2013) Regulation of multiple transcription factors by reactive oxygen species and

effects of pro-inflammatory cytokines released during myocardial infarction on cardiac

differentiation of embryonic stem cells. Int J Cardiol. 168(4):3458-72.

IF: 6.175 - Rank: 11th/125 Journals (Cardiac & Cardiovascular Systems) Google citation: 3

6. Qin HY, Xiao HT, Leung FP, Yang ZJ, Wu JC, Bian ZX (2012) JCM-16021, a chinese herbal

formula, attenuated visceral hyperalgesia in TNBS-induced post-inflammatory irritable bowel

syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats. Evid

Based Complement Alternat Med. 2012:239638.

IF: 2.175 - Rank: 6th/22 Journals (Integrative & Complementary Medicine) Google citation: 3

7. Zhang X, Choi FF, Zhou Y, Leung FP, Tan S, Lin S, Xu H, Jia W, Sung JJ, Cai Z, Bian Z.

Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-

ESI-QTOF-MS-based metabonomics. FEBS J. 2012 279(13):2322-38.

IF: 3.986 - Rank: 89th/291 Journals (Biochemistry & Molecular Biology)

8. Zhang XJ, Leung FP, Hsiao WW, Tan S, Li S, Xu HX, Sung JJ, Bian ZX. (2012). Proteome

profiling of spinal cord and DRG in rats with TNBS-induced colitis. World Journal of

Gastroenterology. World J Gastroenterol. 18(23):2914-28.


6

IF: 2.433 - Rank: 36th/75 Journals (Gastroenterology & Hepatology)

9. Yung LM, Wong WT, Tian XY, Leung FP, Lau CW, Yao X, Chen ZY, Huang Y (2010).

Cranberry juice consumption restores endothelial dysfunction during estrogen deficiency. Eur J

Nutr. 52:1145-1155.

IF: 3.84 - Rank: 17th/79 Journals (Nutrition & Dietetics) Google citation: 4

10. Yung LM, Wong WT, Tian XY, Leung FP, Yung LH, Chen ZY, Yao X, Lau CW, Huang Y.

(2011) Inhibition of renin-angiotensin system reverses endothelial dysfunction and oxidative stress

in estrogen deficient rats. PLoS One. 6(3):e17437.

IF: 3.534 - Rank: 8th/55 Journals (Multidisciplinary sciences) Google citation: 35

11. Kwong AKY, Chen Z, Zhang HM, Leung FP(#), Lam CMC, Ting KY, Zhang LG, Hao Q, Zhang

LH, Lee HC. (2011) Catalysis-based inhibitors of the cell signaling function of CD38.

Biochemistry. 51(1):555-64.

IF:3.194 - Rank:116th/291 Journals (Biochemistry) Google citation: 5

12. Tian XY, Yung LH, Wong WT, Liu J, Leung FP, Liu L, Chen Y, Kong SK, Kwan KM, Ng SM,

Lai PB, Yung LM, Yao X, Huang Y. (2012). Bone morphogenic protein-4 induces endothelial cell

apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. J Mol Cell Cardiol.

52(1):237-44.

IF:5.218 - Rank:20th/125 Journals (Cardiac & Cardiovascular Systems) Google citation: 35

13. Chan YC, Leung FP, Tian XY, Yung LM, Lau CW, Chen ZY, Yao X, Laher I, Huang Y. (2012)

Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized

hamsters fed cholesterol diet. Pharmacol Res. 65(2):182-8.

IF:3.976 - Rank:38th/256 Journals (Pharmacology & Pharmacy) Google citation: 18

14. Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao X, Au CL,

Lau CW, Vanhoutte PM, Cooke JP, Huang Y. (2012) Oxidative stress-dependent cyclooxygenase-

2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats.

Antioxid Redox Signal. 16(4):363-73.

IF:7.667 - Rank: 9th/124 Journals (Endocrinology & Metabolism) Google citation: 26

15. Wong CK, So WY, Law SK, Leung FP, Yau KL, Yao X, Huang Y, Li X, Tsang SY. (2012)

Estrogen controls embryonic stem cell proliferation via store-operated calcium entry & the nuclear

factor of activated T-cells (NFAT). J Cell Physiol. 227(6):2519-30.

IF:3.874 - Rank:12th/79 Journals (Physiology) Google citation:14


7

16. Dong M, Si YQ, Sun SY, Pu XP, Yang ZJ, Zhang LR, Zhang LH, Leung FP, Lam CM, Kwong

AK, Yue J, Zhou Y, Kriksunov IA, Hao Q, Lee HC. (2011) Design, synthesis and biological

characterization of novel inhibitors of CD38. Org Biomol Chem. 9(9):3246-57.

IF:3.487 - Rank:13th/58 Journals (Chemistry, Organic) Google citation: 17

17. Golbidi S, Leung FP, Tsang SY, Huang Y, Laher I. (2010) Menopause: Vasomotor Symptoms,

Systematic Treatments and Self Care Measures. Book Chapter “An overview of Post-

menopausal care: cardiovascular aspects”. Nova Science Publisher, Inc.

18. Wong WT, Tian XY, Chen Y, Leung FP, Liu L, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM,

Tipoe GL, Huang Y. (2010) Bone morphogenic protein-4 impairs endothelial function through

oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circ Res.

2010 Oct 15;107(8):984-91.

IF:11.089 - Rank:4nd/125 Journals (Cardiac & cardiovascular systems) Google citation: 54

19. Yip KH, Huang Y, Leung FP, Lau HY. (2010). Cyclic guanosine monophosphate dependent

pathway contributes to human mast cell inhibitory actions of the nitric oxide donor, diethylamine

NONOate. European Journal of Pharmacology. 632(1-3):86-92.

IF:2.687 - Rank:98th/256 Journals (Pharmacology & pharmacy) Google citation: 6

20. Zhang M, Leung FP, Huang Y, Bian ZX (2010). Up-regulation of L-type calcium channel

mediates increased contractility of colonic smooth muscle in a rat model of irritable bowel

syndrome. Neurogastroenterology & Motility. 22(5):e162-e170.

IF: 3.424 - Rank:21th/75 Journals (Gastroenterology & Hepatology) Google citation: 19

21. Chan YC, Leung FP (#), Wong WT, Tian XY, Yung LM, Lau CW, Tsang SY, Yao X, Chen ZY,

Huang Y (2010). Therapeutically Relevant Concentrations of Raloxifene Dilate Pressurized Rat

Resistance Arteries via Calcium-dependent eNOS Activation. Arteriosclerosis, Thrombosis and

Vascular Biology 30(5):992-999.

IF: 5.533- Rank:8th/68 Journals (Hematology) Google citation: 18

22. Liu CQ, Wong SL, Leung FP, Tian XY, Lau CW, Lu L, Yao X, Chen ZY, Yao T, Huang Y.

(2010). Prostanoid TP receptor-mediated impairment of cyclic AMP-dependent vasorelaxation is

reversed by phosphodiesterase inhibitors. European Journal of Pharmacology. 632(1):45-51.


23. Leung FP, Miller AL, Korzh V, Chong SW, Sleptsova-Freidrich I, Webb SE. (2009) Visualization

of stochastic Ca2+ signals in the formed somites during the early segmentation period in intact,

normally developing zebrafish embryos. Dev Growth Differ. 51(7):617-37.

IF:2.3176 - Rank:97th/157 Journals (Developmental Biol)


8

24. Liu CQ, Leung FP, Wong SL, Wong WT, Lau CW, Lu L, Yao X, Yao T, Huang Y. (2009)

Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent

vasorelaxations: the role of Rho kinase. Biochem Pharmacol. 78(4):374-81.

IF:4.650 - Rank: 25th/256 Journals (Pharmacology & pharmacy) Google citation: 23

25. Yung LM, Huang Y, Laher I, Yao X, Chen ZY, Leung FP(*). (2009) Exercise, vascular wall and

cardiovascular diseases: an update (Part 2). Sports Medicine 39:45-63.

IF:5.320 - Rank:2th/81 Journals (Sports Sciences) Google citation: 73

26. Yip KH, Leung FP, Huang Y, Lau HYA (2009) Inhibition of anti-IgE mediated human mast cell

activation by NO donors is dependent on the NO release kinetics of the donors. Br J Pharmacol.

156(8):1279-1286.


27. Leung KW, Leung FP (#), Mak NK, Joyce Tombran-Tink, Huang Y, Wong RNS (2009).

Protopanaxadiol and protopanaxatriol bind to glucocorticoid and estrogen receptors in endothelial

cells. Br J Pharmacol. 2009 Feb;156(4):626-37. (Co-first author)


28. Hercule HC, Schnuck W, Gross V, Seringer J, Leung FP, Weldon SM, Da Costa Goncalves AC,

Huang Y, Luft FC, Gollasch M (2009) Interaction between P450 eicosanoids and nitric oxide in

the control of arterial tone in mice. Arteriosclerosis, Thrombosis and Vascular Biology. 29(1):54-

60.

IF: 5.533- Rank:8th/68 Journals (Hematology) Google citation: 89

29. Kwan HY, Huang Y, Yao XQ, Leung FP(*). (2009).Role of cyclic nucleotides in the control of

cytosolic Ca2+ levels in vascular endothelial cells. Clin Exp Pharmacol Physiol. 36(9):857-66.

IF: 2.045 - Rank:38th/81 Journals (Physiology) Google citations: 5

30. Wong SL, Leung FP, Lau CW, Yung LM, Lau CW, Yao X, Chen ZY, Vanhoutte PM, Huang Y

(2009) Essential role of cyclooxygenase-2 in endothelium-dependent contraction and the

generation of EDCF(s). Circulation Research. 2009 Jan 30;104(2):228-35.

IF:11.089 - Rank:4nd/125 Journals (Cardiac & cardiovascular systems) Google citation: 93

31. Yung LM, Huang Y, Laher I, Yao X, Chen ZY, Leung FP(*). (2009) Exercise, vascular wall and

cardiovascular diseases: an update (Part 2). Sports Medicine 39:45-63.


32. Yung LM, Leung FP, Wong WT, Tian XY, Yung LH, Chen ZY, Yao XQ, Huang Y. (2008) Tea

polyphenols benefit vascular function. Inflammopharmacology 16:230-234.

Google citation: 40


9

33. Wong CM, Yung LM, Leung FP, Tsang SY, Au CL, Yao X, Cheng HK, Chen ZY, Huang Y

(2008). Raloxifene protects endothelial cells against oxidative stress. Br J Pharmacol. 155(3):326-

34.


34. Leung FP, Yung LM, Laher I, Yao X, Chen ZY, Huang Y. (2008) Exercise, vascular wall and

cardiovascular diseases: an update (Part 1). Sports Medicine 38:1009-1024


35. Liu CQ, Leung FP, Lee VW, Lau CW, Yao X, Lu L, Huang Y. (2008) Prevention of nitroglycerin

tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol.

590(1-3):250-4.

IF:2.787 - Rank:78th/219 Journals (Pharmacology) Google citation: 16

36. Leung FP, Yung LM, Yao X, Laher I, Huang Y. (2008) Stored-operated calcium entry in vascular

smooth muscle. Br J Pharmacol. 153:846-857.


37. Leung FP, Tsang SY, Wong CM, Yung LM, Chan YC, Leung HS, Yao X, Huang Y. (2007)

Raloxifene, tamoxifen and vascular tone. Clin Exp Pharmacol Physiol. 34:809-813.

IF:2.045 - Rank:38th/81 Journals (Physiology) Google citation: 22

38. Chan YC, Leung FP, Yao X, Lau CW, Vanhoutte PM, Huang Y. (2007) Raloxifene modulates

pulmonary vascular reactivity in spontaneously hypertensive rats. J Cardiovasc Pharmacol.

49(6):355-61.

IF:2.111 - Rank:65th/125 Journals (Cardiac & cardiovascular system) Google citation: 10

39. Zhong JC, Huang Y, Yung LM, Lau CW, Leung FP, Wong WT, Lin SG, Yu XY. (2007) The

novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regul Pept. 144(1-3):109-14.

IF:2.276 - Rank:33th/78 Journals (Physiology) Google citation: 35

40. Leung FP, Yung LM, Leung HS, Au CL, Yao X, Vanhoutte PM, Laher I, Huang Y. (2007)

Therapeutic concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation

in vitro. Br J Pharmacol. 152(2):223-9.


41. Tang EH, Leung FP, Huang Y, Feletou M, So KF, Man RY, Vanhoutte PM. (2007) Calcium and

reactive oxygen species increase in endothelial cells in response to releasers of endothelium-

derived contracting factor. Br J Pharmacol. 151(1):15-23.

IF:4.990 - Rank:21th/256 Journals (P Pharmacology & pharmacy) Google citation: 84


10

42. Leung KW, Leung FP, Huang Y, Mak NK, Wong RN. (2007) Non-genomic effects of

ginsenoside-Re in endothelial cells via glucocorticoid receptor. FEBS Lett. 581(13):2423-8.

IF: 3.341 - Rank:25th/74 Journals (Biophysics) Google citation: 33

43. Leung HS, Seto SW, Kwan YW, Leung FP, Au AL, Yung LM, Yao X, Huang Y.(2007)

Endothelium-independent relaxation to raloxifene in porcine coronary artery. Eur J Pharmacol.

555(2-3):178-84.

IF:2.787 - Rank:78th/219 Journals (Pharmacology) Google citation: 25

44. Wong SL, Yung LM, Lau CW, Wong WT, Chan YC, Huang Y, Leung FP(*). (2007) Impact of

periadventitial adipose tissue on arterial tone. Journal of Internal Medicine Concept and Practice.

3(2):139-141.

45. Leung HS, Yung LM, Leung FP, Yao X, Chen ZY, Ko WH, Laher I, Huang Y. (2006) Tamoxifen

dilates porcine coronary arteries: roles for nitric oxide and ouabain-sensitive mechanism. Br J

Pharmacol. 149(6):703-11.

IF:4.990 - Rank:21th/256 Journals (Pharmacology & pharmacy) Google citation:17

46. Leung HS, Leung FP, Yao X, Ko WH, Chen ZY, Vanhoutte PM, Huang Y. (2006) Endothelial

mediators of the acetylcholine-induced relaxation of the rat femoral artery. Vascul Pharmacol.

44(5):299-308.

IF:3.976 - Rank:38th/256 (Pharmacology) Google citation: 21

47. Leung HS, Yao X, Leung FP, Ko WH, Chen ZY, Gollasch M, Huang Y. (2006) Cilnidipine, a

slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial

nitric oxide and [Ca2+]i. Br J Pharmacol. 147(1):55-63.


48. Yung LM, Leung FP, Yao X, Chen ZY, Huang Y. (2006) Reactive oxygen species in vascular wall.

Cardiovascular & Haematological Disorders - Drug Targets 6:1-19.

Google citation: 143

49. Chan YC, Leung FP, Yao X, Lau CW, Vanhoutte PM, Huang Y. Raloxifene relaxes rat pulmonary

arteries and veins: roles of gender, endothelium, and antagonism of Ca2+ influx.(2005) J

Pharmacol Exp Ther. 312(3):1266-71.

IF:3.855 - Rank:44th/256 (Pharmacology & pharmacy) Google citation: 30

50. Leung FP, Yao X, Lau CW, Ko WH, Lu L, Huang Y. (2005) Raloxifene relaxes rat intrarenal

arteries by inhibiting Ca2+ influx.

Am J Physiol Renal Physiol. 289(1):F137-44.

IF:3.3 - Rank:15th/77 (Nephrology) Google citation: 33


11

51. 梁鳳萍，翁勵明，黃聿. 血管平滑肌細胞的容積性鈣內流２００５藥理學進展 p.99-111.

52. Leung FP, Webb SE, Miller AL (2000). On the mechanism of ooplasmic segregation in single-

cell zebrafish embryos. Dev Growth Differ.;42(1):29-40.


53. Leung FP, Webb SE, Miller AL (1998). Calcium transients accompany ooplasmic segregation in

zebrafish embryos. Dev Growth Differ. 40(3):313-26.


CONFERENCE ABSTRACTS & PROCEEDINGS (SELECTED ABSTRACTS)

1. Wong WT, Tian XY, Leung FP, Xu AM, Jiang ZH, Wong RNS, Huang Y. (2009) Protective

Effects of Ginsenosides Against Endothelial Dysfunction In Type 2 Diabetes Mice. Journal of

Hong Kong College of Cardiology. 17:52.

2. Leung FP, Liu Cl, Yung LM, Wong WT, Tian XY, Wang H, Kung HF, Huang Y. Protective effect

of black tea against brain damage after transient middle cerebral artery occlusion in rats-a

proteomic approach. 3rd Scientific Meeting of Asian Society for Vascular Biology. Translation

from Vascular Biology to Clinical Practice, Department of Pharmacology, Yong Loo Lin School

of Medicine, National University of Singapore; August 4th-5th, 2008. (Oral presentation)

3. Wong SL, Leung FP, Lau CW, Vanhoutte PM, Huang Y. (2008) Endothelium-dependent

contractions in hamster aorta: the essential role of cox-2 and prostaglandin F2. 5th International

EDHF symposium: Endothelium, Vasoactive Factors and Inflammation. Tampere, Finland; June

24th-27th, 2008.

4. Yung LM, Wong WT, Tian XY, Leung FP, Chen ZY, Yao XQ, Vanhoutte PM, Huang Y. (2008)

Cranberry juice consumption ameliorates endothelial dysfunction during estrogen deficiency:

balance between NO and ROS. The FASEB Journal. 22:1149.3

5. Yung LM, Wong WT, Leung FP, Yao XQ, Chen ZY, Huang Y. (2008) A Key Role of AT1R in

Endothelial Dysfunction During Estrogen Deficiency The FASEB Journal. 22:1119.5.

6. Law SK, Ng SY, Leung FP, Huang Y, Tsang SY. (2008) Role of Reactive Oxygen Species (ROS)

in Cardiac Differentiation of Embryonic Stem Cells. 6th ISSCR Annual Meeting, Pennsylvania

Convention Center, Philadelphia, PA, USA; June 11th-14th, 2008.

7. Yung LM, Wong WT, Leung FP, Tian XY, Chen ZY, Lau CW, Yao XQ, Huang Y. (2007) Black

Tea Consumption Ameliorates Endothelial Dysfunction In Ovariectomized Rats. Tung Wah Group

of Hospital Eddie Wang Symposium on Integrated Chinese and Western Medicine, Hong Kong.


12

8. Yung LM, Wong WT, Tian XY, Leung FP, Lau CW, Yao XQ, Chen ZY, Vanhoutte PM, Huang

Y. (2007) Cranberry Juice Consumption Ameliorates Endothelial Dysfunction During Estrogen

Deficiency. Journal of Hong Kong College of Cardiology. 15(2):83.

9. Wong WT, Tian XY, Yung LM, Leung FP, Xu AM, Yao XQ, Vanhoutte PM, Huang Y. (2007)

Up-Regulated Angiotensin II Type 1 Receptors Mediate Endothelial Dysfunction In db/db diabetic

Mice. Journal of Hong Kong College of Cardiology. 15(2):87

10. Leung FP, Liu CL, Yung LM, Wong WT, Tian XY, Wang H, Kung HF, Huang Y. (2007)

Protective Effect of Black Tea Against Brain Damage After Transient Middle Cerebral Artery

Occlusion in Rats-A proteomics approach. Journal of Hong Kong College of Cardiology. 15(2);92.

11. Yung LH, Chan YC, Leung FP, Yung LM, Yao X, Huang Y. (2007) Therapeutic concentrations

of raloxifene stimulate increases in nitric oxide and Ca2+ in endothelial cells from rat small

mesenteric artery. Journal of Hong Kong College of Cardiology. 15(2):95.

12. Wong SL, Leung FP, Lau CW, Yung LM, Yao X, Vanhoutte PM, Huang Y. (2007) Prostaglandin

F2 acts as the Major Endothelium-Derived Contracting Factor in the Hamster Aorta. Journal of

Hong Kong College of Cardiology. 15(2):87.

13. Wong WT, Tian XY, Leung FP, Yung LM, Lau CW, Yao X, Vanhoutte PM, Huang Y. (2007)

Cyclooxygenase-dependent Endothelial Dysfunction in Renovascular Hypertension. Journal of

Hong Kong College of Cardiology.

14. Yung LM, Leung FP, Wong WT, Lau CW, Yao XQ, Chen ZY, Vanhoutte PM & Huang Y (2007)

Cranberry juice consumption ameliorates endothelial dysfunction in ovariectomized rats. Life

Science 2007. Oral Communication in Session: Oxidative stress and the endothelium. Abstract#:82.

15. Wong WT, Chen YC, Lee HK, Tian XY, Leung FP, Yung LM, Tipoe G, Yao XQ, Kung XF,

Huang Y (2007) Role of ROS and COX-2 in BMP4-induced Endothelial Dysfunction. Basic &

Clinical Medicine. 27 (Suppl):100.

16. Leung FP, Shi XG, Kung HF, Wang H, Wong WT, Liu CL, Yung LM, Yao X, Lin MCM, Huang

Y. (2007) Potential Biomarkers For Renovascular Hypertension: Proteomic Approach. Physiology

Symposium 2007, Taipei, Taiwan (Oral presentation, p27 of program book).

17. Wong WT, Leung FP, Yung LM, Lau CW, Yao X, Huang Y. (2006) Role Of Cyclooxygenase In

Oscillatory Contractions Of the Renal Artery In Renovascular hypertension. 11th International

Vascular Neuroeffector Mechanisms and Cardiovascular Pharmacology and Medicine Symposia,

Shanghai-Suzhou 2006. Abstract# P35.

18. Wong WT, Leung FP, Yung LM, Yao X, Lau CW, Huang Y. (2006) Oscillatory contraction of

the renal Artery in renovascular hypertension. Physiology Symposium 2006. Abstract#P48.


13

19. Wong SL, Leung FP, Yung LM, Lau CW, Yao X, Vanhoutte PM, Huang Y (2006) COX-

dependent Metabolites Mediate Endothelium-Dependent Vasoconstriction in Young and Old

Hamsters. Physiology Symposium 2006. Abstract#S6.

20. Leung FP, Shi XG, Lau CW, Yung LM, Kung HF, Yao X, Huang RX, Huang Y (2006) Effects

of Artificial Cold Exposure on Vascular Reactivity in Renovascular hypertension. Physiology

Symposium 2006. Abstract#P46.

21. Yung Lm, Leung FP, Yao X, Huang Y (2006) Receptor- & Store-operated Calcium Entry in

Carotid and Renal Arteries. Physiology Symposium 2006. Abstract#P49.

22. Yung LM, Leung FP, Yao X, Vanhoutte PM, Huang Y (2005) Receptor- & Store-Operated

Calcium Entry in Carotid and Renal Arteries Vascular Smooth Muscle Cells. The First Scientific

Meeting of Asian Society for Vascular Biology, Shanghai, October 8th-11th, 2005, P22.

23. Wong CM, Yung LM, Au CL, Yao X, Leung FP, Cheng HK, Vanhoutte PM, Huang Y. (2004)

Raloxifene Ameliorates Endothelial Dysfunction Induced by Free Radical Exposure. Journal of

Hong Kong College of Cardiology. 12:113-P42.

24. Leung FP, Shi XG, Wang H, Kung HF, Huang Y. (2005) Protective Effects of Raloxifene and

Estrogen on Rat Prostate Endothelial Cell Line YPEN-1 Damaged by Hypoxanthine-Xanthine

Oxidase (HXXO) Oxygen Radical Donor System. The Croucher Foundation Advanced Study

Institute Advances in Protein Sciences. Department of Biochemistry, the Chinese University of

Hong Kong, December 12th-17th, 2005.

25. Leung FP, Shi XG, Wang H, Kung HF, Huang Y (2005) Protective Effects of Raloxifene and

Estrogen on Rat Prostate Endothelial Cell Line YPEN-1 damaged by Hypoxanthine-Xanthine

Oxidase (HXXO) Oxygen Radical Donor System. The First Meeting of Asian Society for Vascular

Biology, Shanghai, October 8th - 10th, 2005, P23.

PRACTICAL SKILLS

1. Proficient to set up Zebrafish facility for experimentations such as angiogenesis assay and

drug screening: I have worked in the field of zebrafish research for 7 years in Prof. Andrew Miller’s

laboratory in HKUST.

-Attended Neural Development and Genetics of Zebrafish Summer Course, Marine Biological

Laboratory, Massachusetts, USA

-Received laboratory training in setup zebrafish module developing wild-type and mutant embryos,

techniques of nucleic acid injection, gene-mapping, cell transplantation, in situ hybridization, the


14

labeling of single cells, dissect the zebrafish nervous system, study brain histology, perform behavioral

tests on wild-type and mutant animals, and learn axonal path-finding techniques.

2. Molecular Biology: RNAs Extraction, DNAs Extraction, PCR, real time PCR; Bacterial

Transformation; Cells: Isolation and Culture of many cell lines such as endothelial cells, smooth

muscle cells, human monocytes (THP-1 and U937), PC-12, T lymphocyte cells (Jurkat cells) &

cervical cancer cell (HeLa), human mouse embryonic stem cells; iPSC (induced pluripotent stem cell);

Mammalian Cell Transfection, in vitro Lentivirus Infection, Rhodamin-Phalloidin Staining;

Immunohistochemistry & Histology: Histological and Histochemical Techniques, Paraffin Embedded

Tissue Sections. Protein: Lowry Protein Assay; Western Blotting; Immunostaining and Terminal

deoxynucleotidyl Transferase Biotin-dUTP Nick End Labeling (TUNEL) assay; Flow Cytometry

(Apoptosis & Cell sorting).

3. Animal manipulation: I have extensive experiences in developing animal models for diseases.

Conducted middle cerebral artery occlusion (MCAO; stroke), renovascular hypertensive rat (RHR),

and ovariectomized (OVX) rat models; acute DSS colitis model (inflammatory bowel diseases),

metabolic diseases model (Diet induced obese model), neonatal maternal separation (NMS) model

(irritable bowel syndrome (IBS), Angiotensin II-infused hypertensive model.

4. Imaging: I have experienced in Ca2+, reactive oxygen species (ROS) and nitric oxide in situ

imaging in intact arteries (endothelium and vascular smooth muscle cells). I learnt how to isolate

cardiac cells and do imaging experiments.

5. Proficient in Proteomic analysis & Metabonomic analysis

6. Handling of confocal microscopes (OLYMPUS, BIORAD and LEICA; calcium, nitric oxide,

reactive oxygen species detection), bioluminescent photon imaging using aequorin and

spectrofluorimetric imaging. Experienced working with imaging software such as Metamorph,

MetaFluor, Felix and confocal assistant.

7. Experienced in myographs and organ bath experiments for vascular studies.

8. Other techniques: Organ culture of isolated artery, Primary culture of mouse aortic and

mesenteric artery endothelial cells, Oral glucose tolerance test (OGTT), Blood pressure measurement

curriculum vitae - bch.cuhk.edu.hk...curriculum vitae dr. christina fung ping leung email:...

Documents