CURRICULUM VITAE

ANUJ THAKUR

(B.Sc, M. Sc, Ph.D.)

Correspondence Address

B-185 B, Lajpat Nagar,

Sahibabad, Ghaziabad,

U.P – 201005

Email: anujt13@gmail.com

Mobile: +91-9911754636

Career Objective

To reach such a challenging and rewarding position as a Researcher and educator that demands me to

apply my entire intellectuality and to retain my identity in the society by achieving the summit of

perfection in my duties and responsibilities

Current Position

Research Associate at Mankind Pharma, one of the fastest growing pharmaceutical companies of

India. Job profile includes :-

Designing the synthetic route and executing the multistep organic synthesis of impurities

associated with active pharmaceutical ingredient (API)

Literature search for designing synthetic route using Scifinder.

Characterization of products via their Analytical data (NMR, Mass, HPLC, IR etc.).

Doctorate Details

Thesis entitled “Design, Facile Synthesis and Development of Novel Molecular Hybrids as

Therapeutic Agents” has been submitted on 15/7/2015 and defended on 19/1/16.

Supervisor and Affiliation

Name: Diwan S. Rawat

Designation: Professor (Full)

Department: Department of Chemistry

Institution: University of Delhi, Delhi, India

Research Work

Design and synthesis of novel heterocyclic anti-cancer, anti-malarial and anti-Parkinsonian compounds

based on the recently introduced concept of molecular hybridization.

Synthesized library of quinoline-pyrimidine hybrids and piperidone based C5-curcuminoids through

multi-step synthesis.

Designed and synthesized novel organo-catalytic systems for catalyzing various organic

transformations of synthetic importance, including MCRs.

Reactions like Claisen–Schmidt condensation, knoevenagel condensation, sonogashira coupling,

various nucleophilic substitution reactions, reduction etc were performed at different stages of course.

In-silico studies of most active compounds were performed using Schrodinger Maestro software

Awards & Fellowship

At present availing Senior Research Fellowship from Council of Scientific and Educational Research,

India since January 2013.

Received Junior Research Fellowship from Council of Scientific and Educational Research, India from

January 2011 to December 2012.

Qualified JOINT CSIR-UGC TEST FOR JUNIOR RESEARCH FELLOWSHIP (JRF)

ANDNATIONAL ELIGIBILITY FOR LECTURESHIP (NET) in Chemical Sciences, June 2010

Academic Qualifications

Degree/Examination University/Board Period % Marks

Ph.D. (Chemistry) Dept. of Chemistry,

University of Delhi

Jan-2011 to Jan-2016 -

M.Sc. (Organic Chemistry)

Dept. of Chemistry,

University of Delhi

2008-2010 62.81

B.Sc.Gen (Group A) Zakir Hussain College, University Of Delhi

2004-2007 66.14

10+2 CBSE 2004 72.8

10th ICSE 2002 72.5

Professional Skills

Good knowledge of synthetic organic chemistry, excellent laboratory skills and synthetic route

designing skills with a strong capacity to conduct independent research.

Proficient in handling reactions from mg to gram scale and in purifying the crude product through

column chromatography

Instrument handling like IR, UV, Microwave

Proficient in characterizing compounds through spectroscopic techniques

Skilled in scientific content writing

Working knowledge of Microsoft Word, Excel, Power-Point

Proficient in software packages like ChemDraw, Delta, Origin.

Basic knowledge of Schrodinger Maestro (QSAR and docking)

Research Publications

1. A. Thakur, M. Tripathi, U. Chinna. Rajesh and D. S. Rawat “Ethylenediammonium-diformate

(EDDF) in PEG600: An efficient ambiphilic novel catalytic system for the one-pot synthesis of 4H-

pyrans via Knoevenagel condensation” RSC Adv., 2013, 3, 18142- 18148.

2. A. Thakur, S. I. Khan and D. S. Rawat “Synthesis of piperazine tethered 4-aminoquinoline-pyrimidine

hybrids as potent antimalarial agents” RSC Adv., 2014, 4, 20729-20736.

3. A. Thakur, S. Manohar, C. E. V. Gerena, B. Zayas, V. Kumar, S. V. Malhotra and D. S. Rawat “Novel

3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity

evaluation and mode of action study” Med. Chem. Commun., 2014, 5, 576-586.

4. S. Manohar, A.Thakur, S. I. Khan, G. Sun, N. Ni, B. Wang and D. S. Rawat “Synthesis of

Unsymmetrical C5-Curcuminoids as Potential Anticancer Agents” Lett. Drug Des. Discovery. 2014,

12, 138-149.

5. S. Manohar, A. Thakur, R. Bhatia, S. Walia, P. Ponnan and D. S. Rawat “Antibacterial and

Antioxidant Activity Evaluation of Novel Symmetrical and Unsymmetrical C5-Curcuminoids” Ind. J.

Chem. Sect B. 2015, 54, 1235-1246.

6. M. Tripathi, S. I. Khan, A. Thakur, P. Ponnan and D. S. Rawat “4-Aminoquinoline-pyrimidine-

aminoalkanols: Synthesis, in vitro antimalarial activity, docking studies and ADME predictions” New

J. Chem., 2015, 39, 3474-3483.

7. U. C. Rajesh, R. kholiya, A. Thakur and D. S. Rawat “[TBA][Gly] ionic liquid: Green and sustainable

approach for the synthesis of 3-substituted indoles and indolyl-4H-chromenes”Tetrahedron Lett., 2015,

56, 1790-1793.

8. A. Thakur, P. L. Reddy, M. Tripathi and D. S. Rawat “Facile construction of 3-indolochromenes and

3-indoloxanthenes via EDDF catalyzed one-pot three component reactions” New J. Chem., 2015, 39,

6253-6260.

Manuscript(s) Under Preparation

1. A. Thakur et. al. “Anticancer and antimalarial activity of 9-aminoacridine-pyrimidine conjugates

tethered through piperazine as a rigid linker”.

2. A. Thakur et. al. “In vitro anticancer activity and pre in vivo study in Xenograft models of 4-

aminoquinoline-pyrimidine hybrid”.

3. A. Thakur et. al. “Highly promising in vitro and in vivo antimalarial activity of 4-aminoquinoline-

pyrimidine hybrids”.

4. A. Thakur et. al. “Design, synthesis and evaluation of in vitro antimalarial and anticancer activity

together with in silico studies of 4-aminoquinoline-pyrimidine conjugates”.

5. Anuj Thakur et. al. “Polyvinyl alcohol-sulphonic acid (PVA-SO3H): A novel and recyclable

organocatalyst for N-formylation of amines under metal free and neat condition”

Patent

Diwan S. Rawat, Sunny Manohar, Ummadisetty Chinna Rajesh, Deepak Kumar, Anuj Thakur, Mohit

Tripathi, Panyala Linga Reddy, Shamseer Kulangara Kandi, Satyapavan Vardhineni, Kwang-Soo, and

Chun-Hyung Kim, Amino-quinoline based hybrids and uses thereof, PCT/US2013/28329 (February

28, 2013).

Conferences/ Seminars/ Workshops attended : (in chronological order)

Attended Workshop on “Computational Methods in Physical, Geological Modeling and Drug

Designing” National Academy of Sciences and University of Allahabad, Allahabad, India, September

29th

-1st October, 2011.

Attended Seminar cum Hands-on Training on “Computational Protein Structure Prediction”

Department of Chemistry, Jamia Hamdard, Hamdard Nagar, New Delhi, November 28th

-29th

, 2011.

Presented poster “4-aminoquinoline based scaffolds as potential antimalarial agents” at 16th

ISCB-

2012 International Conference of Indian Society of Chemist and Biologist, Sholapur University,

Sholapur, Maharashtra, January 21st-24

th, 2012.

Presented poster “Novel 4-aminoquinoline based hybrids with improved in vitro and in vivo

antimalarial activity” at Emerging Trends in Development of Drugs and Devices (ETDDD)”

University of Delhi, Delhi, January 21st-23

rd, 2013.

Presented poster “Novel 4-aminoquinoline based hybrids with improved in vitro and in vivo

antimalarial activity” at 19th ISCB-2013 International Conference of Indian society of Chemist and

Biologist, Mohanlal Sukhadia University, Udaipur, Rajasthan, India, March 2nd

-5th

, 2013

My work “Synthesis and anticancer activity of C5-curcuminoids” was presented at 246th

ACS

National Meeting & Exposition, Indianapolis, IN, United States, September 8-12, 2013 (2013), MEDI-

105.

Presented poster “Computational strategy to design novel C5-curcuminoids against cancer” at

Recent Advances in Computational Drug Design, Indian Institute of Science, Bangalore, September

16-17, 2013.

Presented poster “Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogues of

curcumin: Anticancer activity evaluation and mode of action study” at ICCB-2014 International

Conference on Chemical Biology Disease Mechanism and Therapeutics, CSIR-IICT, Hyderabad,

Telangana, India, February 6-8, 2014.

Presented poster “Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogues of

curcumin: Anticancer activity evaluation and mode of action study” at 20th

ISCB-2014

International Conference of Indian society of Chemist and Biologists, Department of Chemistry,

University of Delhi, Delhi, India, March 1- 4, 2014.

Attended Workshop on “Information Literacy & Competency” Delhi University Library System,

University of Delhi, Delhi, India, December 4th

, 2014

Personal Details

Name : Anuj Thakur

Father’s Name : Nawal Kishore

Permanent Address : B-185 B, Lajpat Nagar,

Sahibabad, Ghaziabad,

U.P - 201005

Gender : Male

Nationality : Indian

Date of Birth : 13 May 1986

Age : 29 years

Languages Known : Hindi, English

Marital status : Single

References

Prof. Diwan S. Rawat

Department of Chemistry

University of Delhi

Delhi, 110007

Email: diwansrawat @ gmail.com

Prof. M. Nath

Department of Chemistry

University of Delhi

Delhi, 110007

Email: mnathchemistry @ gmail.com

Prof. A. K. Prasad

Department of Chemistry

University of Delhi

Delhi, 110007

Email: ashokenzyme@yahoo.com

Praveen Verma

Scientific Officer C

Department of Atomic energy

BARC, Mumbai

Email: praveen8970 @ gmail.com

Last updated: 7/12/2015 Signature

Place: Delhi