cubosomes - technology landscape overview

CUBOSOMESTECHNOLOGY THROUGH PATENT GLASS

RUCHICA KUMAR

WHY USE PATENTS AS TECHNOLOGY INDICATOR

Patents provide clear idea of number of players in market for a particular technology and key interest

areas of all players.

Patent data provides an accurate understanding of problems a particular invention is aiming to resolve.

Patent data helps to understand how technology has changed over the years. For example, patent data can

provide evidence of what technical domains were being researched into a decade ago as compared to

technical domains being researched today.

Such a comparison helps in mapping out progress of a technology, knowledge externalities and cross

industry innovation prospects

All the above mentioned points barely scratch the surface of ocean that is patent data analysis

In this report we aim to present few exemplary conclusions that we could draw from a detailed analysis

of cubosome technology.

02-11-2016RUCHICA KUMAR, NOVOCUS LEGAL LLP

2

WHAT ARE CUBOSOMES

Cubosomes are discrete, sub-micron, nanostructured particles of the biscontinuous cubic liquid crystalline phase.

Cubosomes are liquid crystalline nano-structures formed from the cubic phase of lipids, such as monooleate, or

any other amphiphilic macromolecules with the unique property to be dispersed into particles.

Cubosomes are formed at controlled temperatures into lipid bi-layer twisted into three dimension with minimal

surface forming a tightly packed structure with bicontinuous domains of water and lipid. There are three different

proposed phases that these cubic structures can be in: the P-surface, G-surface and D-surface for

primitive, gyroid and diamond structures respectively.

Cubosomes consist of honeycombed (cavernous) structures separating two internal aqueous channels and a large

interfacial area.

02-11-2016RUCHICA KUMAR, NOVOCUS LEGAL LLP 3

FORMATION OF CUBOSOMES

Cubosomes can be manufactured by two distinct methods

1. Top down technique - It is the most widely used in research area, where by bulk cubic phase is first produced

and then dispersed by high energy processing in to cubosomes nanoparticles. Bulk cubic phase is resembling a

clear rigid gel farmed by water swollen crossed linked polymer chains, where as cubic phases are like liquid

crystalline structure. The cubic phases exhibits a yield stress that increases with increasing amount of bilayer

forming surfactant and oils

2. Bottom up technique - In this cubosomes are allowed to form or crystallize from precursors. Almgren et., al.

discuss the formation of cubosomes by dispersing inverse micellar phase droplets in water at 80ºc,and allow

them to slowly cool, gradually droplets get crystallizes to cubosomes. This is more robust in large scale

production of cubosomes.


LANDSCAPE OF CUBOSOME TECHNOLOGY

We have analysed patents related to cubosome technology from year 2006 to 2016.

This analysis has been undertaken for fulfilling following objectives:

To understand evolution of cubosome technology, and to map out its progress in terms of key players, geographical

distribution.

To identify new research areas and new licensing opportunities in field of cubosome technology

To map out applications of cubosome technology, in order to understand new investment or commercialization

opportunities

To study Technology competitiveness amongst various key players and various jurisdictions in order to determine

technology influence and market power of various key players jurisdictions.


AIMS OF THIS PRESENTATION

This presentations aims to present an overview of this study related to cubosome technology.

The presentation would include few charts from the original study and basic explanation of each chart.

Detailed explanation, inferences, conclusions and majority of analysis charts have not been included in this

presentation for purpose of retaining simplicity in the presentation.

Interested candidates may contact the author for complete analysis and report.


EVOLUTION OF CUBOSOME TECHNOLOGY FROM 2006-2016


CNDE

EPFR

INJP

KRPCT

RUUS

0

5

10

15

20

25

30

35

40

45

1999 2000 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

1 1 0 03

7 79

19

38

45 44

21 21

41

6

0 02

58 8

37 7

9 8 711

64

1

Cubosome Technology Progression over the years and across the globe

CN DE EP FR IN JP KR PCT RU US

KEY PLAYERS – CUBOSOME TECHNOLOGY


24

20

21

5

5

5

5

4

4

4

4

3

3

3

3

3

3

0 5 10 15 20 25 30

Guardian Industries Corp.

Univ Dalian Tech

Selecta Biosciences

Knu-Industry Cooperation Foundation

The Regents Of The University Of California

Univ Jilin

Utc Power Corporation

Shin In Ja

Technion Research And Development Foundation Ltd.

Univ Nanjing

Virun

3M Innovative Properties Company

Beijing Institute Of Technology

Guardian Industries Corp (Us)

Korea Institute Of Science And Technology

Nanjing University

Seagate Technology Llc

Key Players - Cubosome Technology

TECHNICAL AREAS UNDER CUBOSOME TECHNOLOGY


01020304050

4740

27 23 22 21 21 19 19 17 15 15 14 13 11

Technical Areas under Cubosome Technology

Medical PreparationsUse of Metallic Compounds for Cubosome formation

Material AnalysisHeat exchange materials

Nanofabrication

0

2

4

6

8

10

12

14

16

18

0 0

17

0 0

21

3

0 0 0

4

01

01

2

0 0 0 0

0

18

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Technical Area Distribution in terms of Key Players

CO-ASSIGNMENT – JOINT VENTURES


4

1

1

2

2

1

1

1

1

1

1

1

1

1

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5

Shin In Ja

Beijing Institute Of Technology

Children&Apos;S Hospital Medical Center

Immundiagnostik Ag

Ocean&Apos;S King Lighting Science &Amp; Technology Co.

Tsinghua University

Anhui Zhongchuang Electronic Information Material Co Ltd

Baxter International Inc.

Bengbu Glass Ind Design Inst

Catholic Kwandong University Industry Foundation

Centre Nat Rech Scient

Centre National De La Recherche Scientifique

China Petroleum &Amp; Chemical Corporation

Ehnsehrm (Ehnstitju Nas&Apos;Onal&Apos; De Lja Sante Eh…

Number of Applications as a Joint Venture and Players involved

Details available in full report

TECHNOLOGY INFLUENCE OF KEY PLAYERS


14.83

0

11.2

3 3.6

1 0.5

3.75

22

5.75

0.67 0.67 0.52.75

1.250

1 1.67 2 1.5 1.670

1.67 2.330.5 0 0 0 0

2

0

5

10

15

20

25

Technology Influence

MARKET POWER OF KEY PLAYERS


21.67

1

37

2 1 1

7.42.8

105

9 9 10

1 1.5

18.67

8

1

8

2 1.33

50

1 1

106

16 5 4

0

10

20

30

40

50

60

Market Power of key players – Cubosome Technology

COMPARISON OF TECHNOLOGY INFLUENCE AND MARKET POWER

OF KEY PLAYERS


05

101520253035404550

14.83

0

11.2

3 3.61 0.5

3.75

22

5.750.67 0.67 0.5

2.75 1.25 0 1 1.67 2 1.5 1.67 0 1.67 2.33 0.5 0 0 0 0 2

21.67

1

37

2 1 1

7.42.8

105

9 9 10

1 1.5

18.67

8

1

8

2 1.33

50

1 1

106

16 5 4

Comparison - Key Players

Technology Influence Market Power

APPLICATIONS OF CUBOSOME TECHNOLOGY


20102011

20132009

20062005

2016

02468

1012141618

Applications of Cubosome Technology Vs Year of Application of Patent

2010 2012 2011 2015 2013 2014 2009 2008 2006 2007 2005 2004 2016

24

1816 15

13 12 12 11 11 10 10

0

5

10

15

20

25

30

Applictions of Cubosome technology

SUMMARY

The presentation gives us an overview of cubosome technology along with its key players, and major applications.

We find upon detailed analysis of Citations, family size, applications of technology, problems solved by technology

that cubosome technology has lot more potential that what is being tapped currently.

There is lot of scope of developing cubosome technology in fields of Medicine, Microscopy amongst others.

Details are discussed in complete report available with the author.


ABOUT THE AUTHOR

Mrs. Ruchica Kumar - An Intellectual Property professional and a registered patent agent who been working in the highly specialized and focused field of Patent Management. As a

registered patent agent she has drafted and prosecuted various patent applications. Her work is focused on technical and strategic facets of patent management involving patent analytics,

acquisition and management. Her area of specialization is patinformatics wherein, she leverages technical aspects of patent drafting, patent valuation and patent citations to generate

comprehensive patent intelligence data. Her sound technical skill set amalgamated with a strong patent knowledge base provides her good understanding of dynamics of cross industry

innovation.

Her competencies include:

• Innovation Forecasting – Analyzing knowledge spill-overs and externalities for forecasting new innovation areas for an organization using patents as indicators

• Patent Drafting in fields of Medical surgical devices and implants, cardiac rhythm management devices, urology, gynecology.

• Patent Invalidation and Patentability assessment

• Technology infusion and diffusion studies using patents as indicators

• Licensing and Technology Transfer in fields of general engineering

• Indian Patent filing and prosecution

• Technology Mapping

• Pre-litigation due diligence


CONTACT US

• We welcome any queries regarding any of the topics you found interesting. We would be happy to provide more details on any of the topics you desire. Also, any queries regarding any issues related to intellectual property are most welcome.

• We can be reached at: Phone: +91-971-154-16163 Email: [email protected], [email protected]

Web: http://novocuslegal.com/index.php


Disclaimer:This report was not prepared as an account of work sponsored by any agency. Neither the author nor any agency thereof, nor any of their employees, nor any of theircontractors, subcontractors or their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or anythird party's use or the results of such use of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights.Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply itsendorsement, recommendation, or favoring by the author or any agency thereof or its contractors or subcontractors. The views and opinions of author expressed herein do not

necessarily state or reflect any factual or strategic inference. This report is for reference and illustration purpose only and should not be used for commercial purposes.

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